Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC10747139
Alguacil et al. (2023) recently presented a study of two tetranuclear complexes of Ru(II) coordinating CuCl2 and NiCl2 fragments (38 and 39, respectively) against six human solid tumors, namely, A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), and WiDr (colon).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "Alguacil", "et", "al.", "(", "2023", ")", "recently", "presented", "a", "study", "of", "two", "tetranuclear", "complexes", "of", "Ru(II", ")", "coordinating", "CuCl2", "and", "NiCl2", "fragments", "(", "38", "and", "39", ",", "respectively", ")", "against", "six", "human", "solid", "tumors", ",", "namely", ",", "A549", "(", "lung", ")", ",", "HBL-100", "(", "breast", ")", ",", "HeLa", "(", "cervix", ")", ",", "SW1573", "(", "lung", ")", ",", "and", "WiDr", "(", "colon", ")", "." ] } ]
PMC11473750
Whole-genome sequencing (WGS) data, containing normalized coverage and ploidy calls for genomic segments in 135 clinically annotated primary neuroblastoma tumours (TARGET neuroblastoma cohort), were obtained through the TARGET data matrix (https://ocg.cancer.gov/programs/target/data-matrix) and further processed using the R statistical language and R Studio as previously described.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Whole-genome", "sequencing", "(", "WGS", ")", "data", ",", "containing", "normalized", "coverage", "and", "ploidy", "calls", "for", "genomic", "segments", "in", "135", "clinically", "annotated", "primary", "neuroblastoma", "tumours", "(", "TARGET", "neuroblastoma", "cohort", ")", ",", "were", "obtained", "through", "the", "TARGET", "data", "matrix", "(", "https://ocg.cancer.gov/programs/target/data-matrix", ")", "and", "further", "processed", "using", "the", "R", "statistical", "language", "and", "R", "Studio", "as", "previously", "described", "." ] } ]
PMC8170755
The relative gene expression was calculated using 2–ΔΔCt method (15).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relative", "gene", "expression", "was", "calculated", "using", "2–ΔΔCt", "method", "(", "15", ")", "." ] } ]
PMC8358006
For 208 activated genes in cancer found associated with GSD loss, a significant increase was observed in H3K4me3, H3K4me1, and H3K27ac levels in KYSE450 cells (Fig. 4a).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "208", "activated", "genes", "in", "cancer", "found", "associated", "with", "GSD", "loss", ",", "a", "significant", "increase", "was", "observed", "in", "H3K4me3", ",", "H3K4me1", ",", "and", "H3K27ac", "levels", "in", "KYSE450", "cells", "(", "Fig.", "4a", ")", "." ] } ]
PMC11483468
The products were separated by SDS-PAGE with TBE buffer in the electrophoresis system with silver stain (25).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "products", "were", "separated", "by", "SDS-PAGE", "with", "TBE", "buffer", "in", "the", "electrophoresis", "system", "with", "silver", "stain", "(", "25", ")", "." ] } ]
PMC9429973
The clinicopathologic features of hMDS have been previously studied, but genetic data and clinical impact of hMDS remain unclear.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "clinicopathologic", "features", "of", "hMDS", "have", "been", "previously", "studied", ",", "but", "genetic", "data", "and", "clinical", "impact", "of", "hMDS", "remain", "unclear", "." ] } ]
PMC10376064
This also accounted for ABCG2, which up to now, has not been associated with DMF or MMF in the literature before.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "also", "accounted", "for", "ABCG2", ",", "which", "up", "to", "now", ",", "has", "not", "been", "associated", "with", "DMF", "or", "MMF", "in", "the", "literature", "before", "." ] } ]
PMC10933092
Among these miRNAs, nine (hsa-miR-92a-2-5p, hsa-miR-135b-5p, hsa-miR-135a-5p, hsa-miR-126-5p, hsa-miR-190a-3p, hsa-miR-200b-5p, hsa-miR-421, hsa-miR-149-3p, and hsa-miR-143-3p) that regulate androgen receptor (AR) expression have been previously reported (Williams et al., 2013; Kroiss et al., 2015; Xu et al., 2015; Du et al., 2016; Meng et al., 2016; Zhai et al., 2017; Bao et al., 2020; Liu et al., 2020).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Among", "these", "miRNAs", ",", "nine", "(", "hsa-miR-92a-2", "-", "5p", ",", "hsa-miR-135b-5p", ",", "hsa-miR-135a-5p", ",", "hsa-miR-126", "-", "5p", ",", "hsa-miR-190a-3p", ",", "hsa-miR-200b-5p", ",", "hsa-miR-421", ",", "hsa-miR-149", "-", "3p", ",", "and", "hsa-miR-143", "-", "3p", ")", "that", "regulate", "androgen", "receptor", "(", "AR", ")", "expression", "have", "been", "previously", "reported", "(", "Williams", "et", "al.", ",", "2013", ";", "Kroiss", "et", "al.", ",", "2015", ";", "Xu", "et", "al.", ",", "2015", ";", "Du", "et", "al.", ",", "2016", ";", "Meng", "et", "al.", ",", "2016", ";", "Zhai", "et", "al.", ",", "2017", ";", "Bao", "et", "al.", ",", "2020", ";", "Liu", "et", "al.", ",", "2020", ")", "." ] } ]
PMC10891340
The animal experiments were conducted strictly in accordance with the national and international animal ethics guidelines.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "animal", "experiments", "were", "conducted", "strictly", "in", "accordance", "with", "the", "national", "and", "international", "animal", "ethics", "guidelines", "." ] } ]
PMC11345828
This underscores the therapeutic potential of combining pro-apoptotic therapy with the inhibition of anti-apoptotic proteins, such as Mcl-1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "underscores", "the", "therapeutic", "potential", "of", "combining", "pro-apoptotic", "therapy", "with", "the", "inhibition", "of", "anti-apoptotic", "proteins", ",", "such", "as", "Mcl-1", "." ] } ]
PMC6182045
The RV144 protocol employed a recombinant canarypox virus vector (VCP1521) to stimulate a cell-mediated immune response, with bivalent recombinant gp120 (rgp120) immunogens (AIDSVAX B/E), to promote an anti-gp120 antibody response (3).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "RV144", "protocol", "employed", "a", "recombinant", "canarypox", "virus", "vector", "(", "VCP1521", ")", "to", "stimulate", "a", "cell-mediated", "immune", "response", ",", "with", "bivalent", "recombinant", "gp120", "(", "rgp120", ")", "immunogens", "(", "AIDSVAX", "B/E", ")", ",", "to", "promote", "an", "anti-gp120", "antibody", "response", "(", "3", ")", "." ] } ]
PMC6222726
Hinokinin (1) was tested for several other biological activities, such as antispasmodic , neurite outgrowth-promoting in PC12 cells , antileukemic , antiproliferative , and neuroprotective activities .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hinokinin", "(", "1", ")", "was", "tested", "for", "several", "other", "biological", "activities", ",", "such", "as", "antispasmodic", ",", "neurite", "outgrowth-promoting", "in", "PC12", "cells", ",", "antileukemic", ",", "antiproliferative", ",", "and", "neuroprotective", "activities", "." ] } ]
PMC10530622
When comparing 24-h urine testing results, patients with OSA had higher supersaturation of uric acid, higher titratable acid, and net acid excretion; lower urinary pH and supersaturation of calcium phosphate; and significantly higher levels of 24-h urinary, uric acid, sodium, potassium, phosphorous, chloride, sulfate and urinary oxalate (35 mg/day vs. 37 mg/day, p = 0.05).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "comparing", "24-h", "urine", "testing", "results", ",", "patients", "with", "OSA", "had", "higher", "supersaturation", "of", "uric", "acid", ",", "higher", "titratable", "acid", ",", "and", "net", "acid", "excretion", ";", "lower", "urinary", "pH", "and", "supersaturation", "of", "calcium", "phosphate", ";", "and", "significantly", "higher", "levels", "of", "24-h", "urinary", ",", "uric", "acid", ",", "sodium", ",", "potassium", ",", "phosphorous", ",", "chloride", ",", "sulfate", "and", "urinary", "oxalate", "(", "35", "mg/day", "vs.", "37", "mg/day", ",", "p", "=", "0.05", ")", "." ] } ]
PMC9429973
Secondary objectives were descriptions of treatment-related adverse events (TRAEs) per NCI CTCAE v5; efficacy by rate of complete remission without or with incomplete hematologic recovery (CR/CRi) and response at EMD sites per NCCN; measurable residual disease negativity (MRD-) by multiparameter flow cytometry (MFC) and high-throughput sequencing (HTS; clonoSEQ) of bone marrow aspirate; and survival.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Secondary", "objectives", "were", "descriptions", "of", "treatment-related", "adverse", "events", "(", "TRAEs", ")", "per", "NCI", "CTCAE", "v5", ";", "efficacy", "by", "rate", "of", "complete", "remission", "without", "or", "with", "incomplete", "hematologic", "recovery", "(", "CR/CRi", ")", "and", "response", "at", "EMD", "sites", "per", "NCCN", ";", "measurable", "residual", "disease", "negativity", "(", "MRD-", ")", "by", "multiparameter", "flow", "cytometry", "(", "MFC", ")", "and", "high-throughput", "sequencing", "(", "HTS", ";", "clonoSEQ", ")", "of", "bone", "marrow", "aspirate", ";", "and", "survival", "." ] } ]
PMC11676674
Under the chosen experimental conditions, our findings show that C. monspeliensis extract at the tested concentrations did not induce a significant increase in micronuclei frequency, thus indicating the absence of a genotoxic potential in CHO-K1 cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Under", "the", "chosen", "experimental", "conditions", ",", "our", "findings", "show", "that", "C.", "monspeliensis", "extract", "at", "the", "tested", "concentrations", "did", "not", "induce", "a", "significant", "increase", "in", "micronuclei", "frequency", ",", "thus", "indicating", "the", "absence", "of", "a", "genotoxic", "potential", "in", "CHO-K1", "cells", "." ] } ]
PMC11754291
Sham conditions were set up nearby, with plates wrapped in aluminum foil to replicate environmental conditions without light exposure.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sham", "conditions", "were", "set", "up", "nearby", ",", "with", "plates", "wrapped", "in", "aluminum", "foil", "to", "replicate", "environmental", "conditions", "without", "light", "exposure", "." ] } ]
PMC10999934
The 50% maximum inhibitory concentration (IC50) of cisplatin decreased in A2780 and SKOV3 ovarian carcinoma cell lines with silenced FBXO2 during an in vitro experiment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "50", "%", "maximum", "inhibitory", "concentration", "(", "IC50", ")", "of", "cisplatin", "decreased", "in", "A2780", "and", "SKOV3", "ovarian", "carcinoma", "cell", "lines", "with", "silenced", "FBXO2", "during", "an", "in", "vitro", "experiment", "." ] } ]
PMC11307990
6HB-DONs and DNA nanotapes were separately incubated with 10% FBS in 1640 medium at 37 °C for 24, 48, and 72 h. Each sample (10 μL) was mixed with 6× loading buffer (2 μL) and analyzed using 1.2% agarose gel electrophoresis at 110 mV for about 45 min in 1× TAE buffer.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "6HB-DONs", "and", "DNA", "nanotapes", "were", "separately", "incubated", "with", "10", "%", "FBS", "in", "1640", "medium", "at", "37", "°", "C", "for", "24", ",", "48", ",", "and", "72", "h.", "Each", "sample", "(", "10", "μL", ")", "was", "mixed", "with", "6", "×", "loading", "buffer", "(", "2", "μL", ")", "and", "analyzed", "using", "1.2", "%", "agarose", "gel", "electrophoresis", "at", "110", "mV", "for", "about", "45", "min", "in", "1", "×", "TAE", "buffer", "." ] } ]
PMC11746942
Notably, S1PR3 participated in early STAT3 activation, as indicated by advanced STAT3 activation by the S1PR3 agonist at 3 h. This result prompted us to hypothesize that other metabolites and receptors further accelerate and sustain STAT3 activation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "S1PR3", "participated", "in", "early", "STAT3", "activation", ",", "as", "indicated", "by", "advanced", "STAT3", "activation", "by", "the", "S1PR3", "agonist", "at", "3", "h.", "This", "result", "prompted", "us", "to", "hypothesize", "that", "other", "metabolites", "and", "receptors", "further", "accelerate", "and", "sustain", "STAT3", "activation", "." ] } ]
PMC11519788
In line with the RT-qPCR array data, ELISA for IL-6 showed that SPOP overexpression in T24 cells inhibited IL-6 secretion from U937 cells, while SPOP depletion in 5637 cells promoted IL-6 secretion from U937 cells (Figure 6C).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "line", "with", "the", "RT-qPCR", "array", "data", ",", "ELISA", "for", "IL-6", "showed", "that", "SPOP", "overexpression", "in", "T24", "cells", "inhibited", "IL-6", "secretion", "from", "U937", "cells", ",", "while", "SPOP", "depletion", "in", "5637", "cells", "promoted", "IL-6", "secretion", "from", "U937", "cells", "(", "Figure", "6C", ")", "." ] } ]
PMC7917457
All viruses were amplified in A549 or HEK293 cells and purified on double-cesium chloride gradients and stored below −60°C in an A195 adenoviral storage buffer.
[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "viruses", "were", "amplified", "in", "A549", "or", "HEK293", "cells", "and", "purified", "on", "double-cesium", "chloride", "gradients", "and", "stored", "below", "−60", "°", "C", "in", "an", "A195", "adenoviral", "storage", "buffer", "." ] } ]
PMC11401358
As shown in Fig. 2B, the intracellular ROS level of NIH 3T3 cells increased dramatically upon treatment with 100 μM H2O2 for 30 min, while the intracellular ROS level was obviously decreased when the cells were pretreated with different biomaterials (Fig. 2B and Fig. S2).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "shown", "in", "Fig.", "2B", ",", "the", "intracellular", "ROS", "level", "of", "NIH", "3T3", "cells", "increased", "dramatically", "upon", "treatment", "with", "100", "μM", "H2O2", "for", "30", "min", ",", "while", "the", "intracellular", "ROS", "level", "was", "obviously", "decreased", "when", "the", "cells", "were", "pretreated", "with", "different", "biomaterials", "(", "Fig.", "2B", "and", "Fig.", "S2", ")", "." ] } ]
PMC11224020
No statistical methods were used to predetermine sample sizes, but our sample sizes are similar to those reported in previous publications.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "statistical", "methods", "were", "used", "to", "predetermine", "sample", "sizes", ",", "but", "our", "sample", "sizes", "are", "similar", "to", "those", "reported", "in", "previous", "publications", "." ] } ]
PMC11544122
d, e SNX9 binding to CXCR4 was examined by microscale thermophoresis (MST).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", ",", "e", "SNX9", "binding", "to", "CXCR4", "was", "examined", "by", "microscale", "thermophoresis", "(", "MST", ")", "." ] } ]
PMC7153288
The genome sequence was used for gene prediction and annotation as well as analysis to find putative biosynthetic gene clusters for secondary metabolites in Streptomyces sp. SS1-1.Data source locationCenter for Research and Application in Bioscience, Ho Chi Minh City, VietnamData accessibilityData are available within this article.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "genome", "sequence", "was", "used", "for", "gene", "prediction", "and", "annotation", "as", "well", "as", "analysis", "to", "find", "putative", "biosynthetic", "gene", "clusters", "for", "secondary", "metabolites", "in", "Streptomyces", "sp.", "SS1", "-", "1.Data", "source", "locationCenter", "for", "Research", "and", "Application", "in", "Bioscience", ",", "Ho", "Chi", "Minh", "City", ",", "VietnamData", "accessibilityData", "are", "available", "within", "this", "article", "." ] } ]
PMC11754291
Statistically significant differences between days for each treatment condition are marked by crosses ( for p < 0.05, for p < 0.01).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistically", "significant", "differences", "between", "days", "for", "each", "treatment", "condition", "are", "marked", "by", "crosses", "(", "for", "p", "<", "0.05", ",", "for", "p", "<", "0.01", ")", "." ] } ]
PMC9599726
The expression of a series of key ferroptotic genes (i.e., GPX4, NRF2, TFRC, SLC7A11 ACSL4, FTH1, and HMOX1), known to be affected following ferroptosis induction , was analyzed (Figure 7A).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", "a", "series", "of", "key", "ferroptotic", "genes", "(", "i.e.", ",", "GPX4", ",", "NRF2", ",", "TFRC", ",", "SLC7A11", "ACSL4", ",", "FTH1", ",", "and", "HMOX1", ")", ",", "known", "to", "be", "affected", "following", "ferroptosis", "induction", ",", "was", "analyzed", "(", "Figure", "7A", ")", "." ] } ]
PMC10530622
Since its discovery in 2004, RNAi technology has been extensively utilized in drug development and has advanced into clinical trials .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "its", "discovery", "in", "2004", ",", "RNAi", "technology", "has", "been", "extensively", "utilized", "in", "drug", "development", "and", "has", "advanced", "into", "clinical", "trials", "." ] } ]
PMC7642379
To discover significant alterations of gene sets and metabolic pathways between HEK293 cell lines, the Piano package in R was used.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "discover", "significant", "alterations", "of", "gene", "sets", "and", "metabolic", "pathways", "between", "HEK293", "cell", "lines", ",", "the", "Piano", "package", "in", "R", "was", "used", "." ] } ]
PMC9429973
Methods: Pts aged ≥18 years (yrs) with relapsed/refractory AML (R/R) or pts with AML aged ≥ 75 or 18 -74 with comorbid conditions prohibiting intensive chemotherapy were eligible to participate (frontline-FL).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Pts", "aged", "≥18", "years", "(", "yrs", ")", "with", "relapsed/refractory", "AML", "(", "R/R", ")", "or", "pts", "with", "AML", "aged", "≥", "75", "or", "18", "-74", "with", "comorbid", "conditions", "prohibiting", "intensive", "chemotherapy", "were", "eligible", "to", "participate", "(", "frontline-FL", ")", "." ] } ]
PMC11594806
Efforts to improve DTX efficacy include encapsulating it in biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles for treating non-small-cell lung cancer (NSCLC).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Efforts", "to", "improve", "DTX", "efficacy", "include", "encapsulating", "it", "in", "biodegradable", "poly(lactic-co-glycolic", "acid", ")", "(", "PLGA", ")", "nanoparticles", "for", "treating", "non-small-cell", "lung", "cancer", "(", "NSCLC", ")", "." ] } ]
PMC11023271
It is thus possible that RIPK4 in keratinocytes is down-regulated by LPA in serum, which is released during wounding or carcinogenesis, or by LPA from resident tissues during pathophysiological processes; and this down-regulation leads to elevated proliferation of keratinocytes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "thus", "possible", "that", "RIPK4", "in", "keratinocytes", "is", "down-regulated", "by", "LPA", "in", "serum", ",", "which", "is", "released", "during", "wounding", "or", "carcinogenesis", ",", "or", "by", "LPA", "from", "resident", "tissues", "during", "pathophysiological", "processes", ";", "and", "this", "down-regulation", "leads", "to", "elevated", "proliferation", "of", "keratinocytes", "." ] } ]
PMC11772449
Sorafenib (CSNpharm, CSN10381), Pirfenidone (MCE, HY-B0673), Lipofectamine 2000 (Invitrogen, 11,668,500), DAPI (Invitrogen, 62,248), Ferrostatin-1 (MCE, HY-100579), SP600125 (MCE, HY-12041), Birinapant (MCE, HY-16591), Belnacasan (MCE, HY-13205), Wortmannin (MCE, HY-10197), SBI-0206965 (MCE, HY-16966), Bafilomycin A1 (MCE, HY-100558), Protein A/G Magnetic Beads (MCE, HY-K0202).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sorafenib", "(", "CSNpharm", ",", "CSN10381", ")", ",", "Pirfenidone", "(", "MCE", ",", "HY-B0673", ")", ",", "Lipofectamine", "2000", "(", "Invitrogen", ",", "11,668,500", ")", ",", "DAPI", "(", "Invitrogen", ",", "62,248", ")", ",", "Ferrostatin-1", "(", "MCE", ",", "HY-100579", ")", ",", "SP600125", "(", "MCE", ",", "HY-12041", ")", ",", "Birinapant", "(", "MCE", ",", "HY-16591", ")", ",", "Belnacasan", "(", "MCE", ",", "HY-13205", ")", ",", "Wortmannin", "(", "MCE", ",", "HY-10197", ")", ",", "SBI-0206965", "(", "MCE", ",", "HY-16966", ")", ",", "Bafilomycin", "A1", "(", "MCE", ",", "HY-100558", ")", ",", "Protein", "A/G", "Magnetic", "Beads", "(", "MCE", ",", "HY-K0202", ")", "." ] } ]
PMC11762280
Table 1The preparation of medications in animal studies.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "1The", "preparation", "of", "medications", "in", "animal", "studies", "." ] } ]
PMC11472639
Future research should consider the impact of exercise – and its timing relative to daratumumab therapy – on immune cells and clonal plasma cells in vivo.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Future", "research", "should", "consider", "the", "impact", "of", "exercise", "–", "and", "its", "timing", "relative", "to", "daratumumab", "therapy", "–", "on", "immune", "cells", "and", "clonal", "plasma", "cells", "in", "vivo", "." ] } ]
PMC11519567
A Schematic of workflow for screening small molecules capable of disrupting SS18-SSX condensates.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "Schematic", "of", "workflow", "for", "screening", "small", "molecules", "capable", "of", "disrupting", "SS18-SSX", "condensates", "." ] } ]
PMC9429973
Treatment continued until SF levels were ≥1000 μg/L at 2 consecutive visits (SF threshold) or 12 months.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "continued", "until", "SF", "levels", "were", "≥1000", "μg/L", "at", "2", "consecutive", "visits", "(", "SF", "threshold", ")", "or", "12", "months", "." ] } ]
PMC8316344
Membrane fractions were extracted by a Fatty Acid Extraction Kit, while AA and AdA were measured by ELISA-based kits.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Membrane", "fractions", "were", "extracted", "by", "a", "Fatty", "Acid", "Extraction", "Kit", ",", "while", "AA", "and", "AdA", "were", "measured", "by", "ELISA-based", "kits", "." ] } ]
PMC11665555
Thus, OXCT1 KO caused a metabolic shift toward anaerobic metabolism, yielding lower ATP production; this suggests that OXCT1 expression is necessary for an elevated respiration and survival under gemcitabine treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "OXCT1", "KO", "caused", "a", "metabolic", "shift", "toward", "anaerobic", "metabolism", ",", "yielding", "lower", "ATP", "production", ";", "this", "suggests", "that", "OXCT1", "expression", "is", "necessary", "for", "an", "elevated", "respiration", "and", "survival", "under", "gemcitabine", "treatment", "." ] } ]
PMC11650848
However, CTCF has also been shown to interact with other proteins, such as cohesin to modify chromatin through formation of loops to enable interaction between groups of genes in trans .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "CTCF", "has", "also", "been", "shown", "to", "interact", "with", "other", "proteins", ",", "such", "as", "cohesin", "to", "modify", "chromatin", "through", "formation", "of", "loops", "to", "enable", "interaction", "between", "groups", "of", "genes", "in", "trans", "." ] } ]
PMC11075223
Lignan compounds in Cimicifugae Rhizoma are divided into four categories according to their characteristics and structural differences.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lignan", "compounds", "in", "Cimicifugae", "Rhizoma", "are", "divided", "into", "four", "categories", "according", "to", "their", "characteristics", "and", "structural", "differences", "." ] } ]
PMC9429973
K-aCD38 was used in patients of 63.5y, with an ECOG ≥ 2 for 10%, and comorbidities (≥ 1) for 37.1%.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "K-aCD38", "was", "used", "in", "patients", "of", "63.5y", ",", "with", "an", "ECOG", "≥", "2", "for", "10", "%", ",", "and", "comorbidities", "(", "≥", "1", ")", "for", "37.1", "%", "." ] } ]
PMC9429973
Summary/Conclusion: Progression of SCR was seen in more than a quarter of the patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Summary/Conclusion", ":", "Progression", "of", "SCR", "was", "seen", "in", "more", "than", "a", "quarter", "of", "the", "patients", "." ] } ]
PMC11599565
In summary, the cells responded to changes in ectodermal gene expression, and the activation of the Snail pathway served as a mechanism to restore homeostasis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "summary", ",", "the", "cells", "responded", "to", "changes", "in", "ectodermal", "gene", "expression", ",", "and", "the", "activation", "of", "the", "Snail", "pathway", "served", "as", "a", "mechanism", "to", "restore", "homeostasis", "." ] } ]
PMC11082662
Eukaryotic cell membranes mainly comprise sphingolipids and cholesterol, which play essential roles in regulating cellular signaling pathways (6).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eukaryotic", "cell", "membranes", "mainly", "comprise", "sphingolipids", "and", "cholesterol", ",", "which", "play", "essential", "roles", "in", "regulating", "cellular", "signaling", "pathways", "(", "6", ")", "." ] } ]
PMC6835762
This hydroxyl moiety results in a polymer open to a variety of further functionalizations via simple and accessible chemistry.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "hydroxyl", "moiety", "results", "in", "a", "polymer", "open", "to", "a", "variety", "of", "further", "functionalizations", "via", "simple", "and", "accessible", "chemistry", "." ] } ]
PMC11001582
We also analyzed a published dataset of laser-capture microdissected motor neurons from spinal cord of patients with C9ALS (ref. )
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "analyzed", "a", "published", "dataset", "of", "laser-capture", "microdissected", "motor", "neurons", "from", "spinal", "cord", "of", "patients", "with", "C9ALS", "(", "ref", ".", ")" ] } ]
PMC11489351
This is performed on each individual well.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "performed", "on", "each", "individual", "well", "." ] } ]
PMC11637820
Graphing and statistical analysis were performed using GraphPad Prism 8.0.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Graphing", "and", "statistical", "analysis", "were", "performed", "using", "GraphPad", "Prism", "8.0", "." ] } ]
PMC11394227
Tens of thousands of cells were collected for each sample.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tens", "of", "thousands", "of", "cells", "were", "collected", "for", "each", "sample", "." ] } ]
PMC11461874
We conclude that TRAF7 regulates circadian clock oscillation through destabilization of DBP protein.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "conclude", "that", "TRAF7", "regulates", "circadian", "clock", "oscillation", "through", "destabilization", "of", "DBP", "protein", "." ] } ]
PMC11473750
Analysis of segmental CNVs across Chromosome 11 in tumour tissues from the TARGET neuroblastoma patient cohort (n = 135) revealed that 50% of MYCN non-amplified patients (n = 103) had a loss of the 11q13.14-ter region compared with only 6.25% of MYCN amplified patients (n = 32) (Fig. 6a, b).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Analysis", "of", "segmental", "CNVs", "across", "Chromosome", "11", "in", "tumour", "tissues", "from", "the", "TARGET", "neuroblastoma", "patient", "cohort", "(", "n", "=", "135", ")", "revealed", "that", "50", "%", "of", "MYCN", "non-amplified", "patients", "(", "n", "=", "103", ")", "had", "a", "loss", "of", "the", "11q13.14-ter", "region", "compared", "with", "only", "6.25", "%", "of", "MYCN", "amplified", "patients", "(", "n", "=", "32", ")", "(", "Fig.", "6a", ",", "b", ")", "." ] } ]
PMC11754432
In addition to siRNA-mediated silencing, ML351, a lipoxygenase inhibitor, was utilised to investigate the role of ALOX15B in keratinocyte inflammation in a 3D environment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", "siRNA-mediated", "silencing", ",", "ML351", ",", "a", "lipoxygenase", "inhibitor", ",", "was", "utilised", "to", "investigate", "the", "role", "of", "ALOX15B", "in", "keratinocyte", "inflammation", "in", "a", "3D", "environment", "." ] } ]
PMC11783017
The results demonstrate that the observed increase in ATP levels is consistent with ICD induction, wherein extracellular ATP promotes dendritic cell activation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "demonstrate", "that", "the", "observed", "increase", "in", "ATP", "levels", "is", "consistent", "with", "ICD", "induction", ",", "wherein", "extracellular", "ATP", "promotes", "dendritic", "cell", "activation", "." ] } ]
PMC11519077
When the cells have adhered to the bottom of the container, discard the culture medium on the cells' surface and slowly replace it with the same amount of fresh culture medium.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "the", "cells", "have", "adhered", "to", "the", "bottom", "of", "the", "container", ",", "discard", "the", "culture", "medium", "on", "the", "cells", "'", "surface", "and", "slowly", "replace", "it", "with", "the", "same", "amount", "of", "fresh", "culture", "medium", "." ] } ]
PMC10380508
In this study, we conducted a comprehensive analysis of publicly available renal cell carcinoma (RCC) data from The Cancer Genome Atlas (TCGA) to explore the significance of the PAX gene family in RCC (Figure 1).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "we", "conducted", "a", "comprehensive", "analysis", "of", "publicly", "available", "renal", "cell", "carcinoma", "(", "RCC", ")", "data", "from", "The", "Cancer", "Genome", "Atlas", "(", "TCGA", ")", "to", "explore", "the", "significance", "of", "the", "PAX", "gene", "family", "in", "RCC", "(", "Figure", "1", ")", "." ] } ]
PMC11286266
The beads were then recovered by centrifugation (845 × g, 3 min) and washed four times with washing buffer (50 mM Tris–HCl, 1 mM EDTA, 0.1% Triton X-100) and one more with PBS.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "beads", "were", "then", "recovered", "by", "centrifugation", "(", "845", "×", "g", ",", "3", "min", ")", "and", "washed", "four", "times", "with", "washing", "buffer", "(", "50", "mM", "Tris", "–", "HCl", ",", "1", "mM", "EDTA", ",", "0.1", "%", "Triton", "X-100", ")", "and", "one", "more", "with", "PBS", "." ] } ]
PMC9429973
Aims: The aim of the present study is to investigate the efficacy and safety of KRd regimen in the setting of RRMM treated in real-life.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "The", "aim", "of", "the", "present", "study", "is", "to", "investigate", "the", "efficacy", "and", "safety", "of", "KRd", "regimen", "in", "the", "setting", "of", "RRMM", "treated", "in", "real-life", "." ] } ]
PMC11266100
Therefore, there is a significant emphasis on the importance of research in electroporation-based gene electrotransfer, particularly in parametric optimization to ensure higher transfection efficacy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "there", "is", "a", "significant", "emphasis", "on", "the", "importance", "of", "research", "in", "electroporation-based", "gene", "electrotransfer", ",", "particularly", "in", "parametric", "optimization", "to", "ensure", "higher", "transfection", "efficacy", "." ] } ]
PMC9429973
Aims: Since the DEK oncogene has not been studied in DLBCL previously, the aim of this work is to study the prognostic impact of DEK mRNA expression levels in DLBCL.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "Since", "the", "DEK", "oncogene", "has", "not", "been", "studied", "in", "DLBCL", "previously", ",", "the", "aim", "of", "this", "work", "is", "to", "study", "the", "prognostic", "impact", "of", "DEK", "mRNA", "expression", "levels", "in", "DLBCL", "." ] } ]
PMC11599565
Naturally occurring cells with distinctive morphology in SKOV3 cells (A-C).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Naturally", "occurring", "cells", "with", "distinctive", "morphology", "in", "SKOV3", "cells", "(", "A-C", ")", "." ] } ]
PMC11095939
n.s.,
[ { "tags": [ "O", "O", "O" ], "tokens": [ "n.s", ".", "," ] } ]
PMC11266100
The exemplary images of animals featuring 4T1-Luc tumors are shown in Figure 7.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "exemplary", "images", "of", "animals", "featuring", "4T1-Luc", "tumors", "are", "shown", "in", "Figure", "7", "." ] } ]
PMC9429973
The patient with PMBCL, responded partially after Glofitamab and had mediastinal radiotherapy as bridging therapy to CAR-T therapy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "patient", "with", "PMBCL", ",", "responded", "partially", "after", "Glofitamab", "and", "had", "mediastinal", "radiotherapy", "as", "bridging", "therapy", "to", "CAR-T", "therapy", "." ] } ]
PMC11098378
Reactions were incubated for 18 h at 30°C before the addition of 2X loading buffer containing β-mercaptoethanol (BME).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reactions", "were", "incubated", "for", "18", "h", "at", "30", "°", "C", "before", "the", "addition", "of", "2X", "loading", "buffer", "containing", "β-mercaptoethanol", "(", "BME", ")", "." ] } ]
PMC11409031
Show the genomic locations of the 10 model genes on chromosomes. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Show", "the", "genomic", "locations", "of", "the", "10", "model", "genes", "on", "chromosomes", ".", "(" ] } ]
PMC9429973
Treatments received at 1L were R-CHOP (482; 74.7%), R-miniCHOP (86; 13.3%), high dose anthracycline-based regimen (62; 9.6%) and non-anthracycline based regimen (15; 2.3%).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatments", "received", "at", "1L", "were", "R-CHOP", "(", "482", ";", "74.7", "%", ")", ",", "R-miniCHOP", "(", "86", ";", "13.3", "%", ")", ",", "high", "dose", "anthracycline-based", "regimen", "(", "62", ";", "9.6", "%", ")", "and", "non-anthracycline", "based", "regimen", "(", "15", ";", "2.3", "%", ")", "." ] } ]
PMC11401358
Generally, the expression levels of these genes in the SF group were similar to the expression levels of these genes in the PBS group, but they were significantly different in the H2O2 group.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Generally", ",", "the", "expression", "levels", "of", "these", "genes", "in", "the", "SF", "group", "were", "similar", "to", "the", "expression", "levels", "of", "these", "genes", "in", "the", "PBS", "group", ",", "but", "they", "were", "significantly", "different", "in", "the", "H2O2", "group", "." ] } ]
PMC9429973
Thromboembolic prophylaxis was held for active bleeding or platelet count threshold of < 30,000/uL. The overall mortality rate was 70.0%.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thromboembolic", "prophylaxis", "was", "held", "for", "active", "bleeding", "or", "platelet", "count", "threshold", "of", "<", "30,000/uL.", "The", "overall", "mortality", "rate", "was", "70.0", "%", "." ] } ]
PMC8633974
Untreated control cells showed significantly higher fold stimulation; P=0.01 (Unpaired t-test).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Untreated", "control", "cells", "showed", "significantly", "higher", "fold", "stimulation", ";", "P=0.01", "(", "Unpaired", "t-test", ")", "." ] } ]
PMC11703992
Glutamate metabolism maintains the critical TCA cycle in response to glucose deprivation or reduced pyruvate supply by catabolizing glutamine into alpha-ketoglutarate (α-KG) to replenish TCA cycle intermediates and sustain mitochondrial respiration , which was completed by aspartate aminotransferase (AST).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Glutamate", "metabolism", "maintains", "the", "critical", "TCA", "cycle", "in", "response", "to", "glucose", "deprivation", "or", "reduced", "pyruvate", "supply", "by", "catabolizing", "glutamine", "into", "alpha-ketoglutarate", "(", "α-KG", ")", "to", "replenish", "TCA", "cycle", "intermediates", "and", "sustain", "mitochondrial", "respiration", ",", "which", "was", "completed", "by", "aspartate", "aminotransferase", "(", "AST", ")", "." ] } ]
PMC11534377
This mechanism is universal in all malignant pathologies but varies deeply between patients and cancer types.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "mechanism", "is", "universal", "in", "all", "malignant", "pathologies", "but", "varies", "deeply", "between", "patients", "and", "cancer", "types", "." ] } ]
PMC11604768
For example, dexamethasone treatment caused significant upregulation of TRE units containing motifs for two nuclear receptor superfamily class I (steroid) members: androgen receptor (AR) and glucocorticoid receptor (NR3C1) (Fig. 3b).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", "dexamethasone", "treatment", "caused", "significant", "upregulation", "of", "TRE", "units", "containing", "motifs", "for", "two", "nuclear", "receptor", "superfamily", "class", "I", "(", "steroid", ")", "members", ":", "androgen", "receptor", "(", "AR", ")", "and", "glucocorticoid", "receptor", "(", "NR3C1", ")", "(", "Fig.", "3b", ")", "." ] } ]
PMC8956657
A cartoon representation is shown below highlighting the hydrogen bonds (see Supplementary Table 13 for a full list of hydrogen bond interactions).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "cartoon", "representation", "is", "shown", "below", "highlighting", "the", "hydrogen", "bonds", "(", "see", "Supplementary", "Table", "13", "for", "a", "full", "list", "of", "hydrogen", "bond", "interactions", ")", "." ] } ]
PMC5330095
from the University of Sydney, Australia and B.Sc. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "from", "the", "University", "of", "Sydney", ",", "Australia", "and", "B.Sc", ".", "(" ] } ]
PMC10605143
For the analysis of differences between the compared groups with normal distribution, the quality of the mean values was verified by the ANOVA test with a pairwise comparison performed with the HSD Tukey test or the Games–Howell test depending on the homogeneity of variance.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "analysis", "of", "differences", "between", "the", "compared", "groups", "with", "normal", "distribution", ",", "the", "quality", "of", "the", "mean", "values", "was", "verified", "by", "the", "ANOVA", "test", "with", "a", "pairwise", "comparison", "performed", "with", "the", "HSD", "Tukey", "test", "or", "the", "Games", "–", "Howell", "test", "depending", "on", "the", "homogeneity", "of", "variance", "." ] } ]
PMC10538569
Gating strategy for analysis of DC : TC cocultures.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gating", "strategy", "for", "analysis", "of", "DC", ":", "TC", "cocultures", "." ] } ]
PMC9429973
Aims: The study aimed at describing functional differences between PI-sensitive MM1S cells (MM1S WT) and their daughter cells, resistant to either bortezomib (MM1S/R BTZ) or carfilzomib (MM1S/R CFZ), as well as between both resistant cell lines.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "The", "study", "aimed", "at", "describing", "functional", "differences", "between", "PI-sensitive", "MM1S", "cells", "(", "MM1S", "WT", ")", "and", "their", "daughter", "cells", ",", "resistant", "to", "either", "bortezomib", "(", "MM1S/R", "BTZ", ")", "or", "carfilzomib", "(", "MM1S/R", "CFZ", ")", ",", "as", "well", "as", "between", "both", "resistant", "cell", "lines", "." ] } ]
PMC3675084
BPR0L075 can induce cell death by a mechanism that is not reliant on apoptosis induction, and thus representing a promising microtubule therapeutic for the treatment of multidrug-resistant ovarian cancer.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BPR0L075", "can", "induce", "cell", "death", "by", "a", "mechanism", "that", "is", "not", "reliant", "on", "apoptosis", "induction", ",", "and", "thus", "representing", "a", "promising", "microtubule", "therapeutic", "for", "the", "treatment", "of", "multidrug-resistant", "ovarian", "cancer", "." ] } ]
PMC10178190
TAMs constitute the main population of immune cells present in the ovarian tumor microenvironment .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TAMs", "constitute", "the", "main", "population", "of", "immune", "cells", "present", "in", "the", "ovarian", "tumor", "microenvironment", "." ] } ]
PMC5925824
One- or two-way ANOVA was used for statistical analysis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One-", "or", "two-way", "ANOVA", "was", "used", "for", "statistical", "analysis", "." ] } ]
PMC10297204
The aim of this study was to determine the effective concentration of ethanol for achieving an anti-tumor effect while avoiding neurotoxicity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "aim", "of", "this", "study", "was", "to", "determine", "the", "effective", "concentration", "of", "ethanol", "for", "achieving", "an", "anti-tumor", "effect", "while", "avoiding", "neurotoxicity", "." ] } ]
PMC9429973
FGF23 is also enhanced in th3 BM fluids associated to its increased expression by bone and BM erythroid cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FGF23", "is", "also", "enhanced", "in", "th3", "BM", "fluids", "associated", "to", "its", "increased", "expression", "by", "bone", "and", "BM", "erythroid", "cells", "." ] } ]
PMC9712534
Quantitative analysis of fluorescence recovery of EGFP-TOP2B WT, H58Y, H58Y/G180I, and H58Y/L185F (n = 10; bars, SD).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Quantitative", "analysis", "of", "fluorescence", "recovery", "of", "EGFP-TOP2B", "WT", ",", "H58Y", ",", "H58Y/G180I", ",", "and", "H58Y/L185F", "(", "n", "=", "10", ";", "bars", ",", "SD", ")", "." ] } ]
PMC8633974
Radioactive counts per minute (CPM), proportionate to the amount of virus contained in sample culture supernatant, were normalized to trypan blue-based cell counts taken at time of harvest.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Radioactive", "counts", "per", "minute", "(", "CPM", ")", ",", "proportionate", "to", "the", "amount", "of", "virus", "contained", "in", "sample", "culture", "supernatant", ",", "were", "normalized", "to", "trypan", "blue-based", "cell", "counts", "taken", "at", "time", "of", "harvest", "." ] } ]
PMC11718109
High magnifications of box areas are shown on the right for each panel.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High", "magnifications", "of", "box", "areas", "are", "shown", "on", "the", "right", "for", "each", "panel", "." ] } ]
PMC9429973
In the current era of CAR-T cell therapy and bispecific antibodies, the characterization of the immune cellular populations in the blood becomes very relevant.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "current", "era", "of", "CAR-T", "cell", "therapy", "and", "bispecific", "antibodies", ",", "the", "characterization", "of", "the", "immune", "cellular", "populations", "in", "the", "blood", "becomes", "very", "relevant", "." ] } ]
PMC11767725
Th17 cells secrete IL-17A, IL-17F, and IL-22, which promote keratinocyte hyperproliferation and inhibit proper differentiation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Th17", "cells", "secrete", "IL-17A", ",", "IL-17F", ",", "and", "IL-22", ",", "which", "promote", "keratinocyte", "hyperproliferation", "and", "inhibit", "proper", "differentiation", "." ] } ]
PMC11700247
IFN-γ spots of an ELISPOT assay after AH1 peptide stimulation of splenocytes from mice that received ACT.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IFN-γ", "spots", "of", "an", "ELISPOT", "assay", "after", "AH1", "peptide", "stimulation", "of", "splenocytes", "from", "mice", "that", "received", "ACT", "." ] } ]
PMC11755467
CEM-SS and MT-4 cells were reverse transfected using RNAiMax™ (ThermoFisher Scientific, Waltham, MA, USA) as described below using Cy3-labeled pre-miR and anti-miR-negative controls #1 (ThermoFisher Scientific AM17120 and AM17011) in 3, 30, and 90 nM final concentrations each or mock transfected.
[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CEM-SS", "and", "MT-4", "cells", "were", "reverse", "transfected", "using", "RNAiMax", "™", "(", "ThermoFisher", "Scientific", ",", "Waltham", ",", "MA", ",", "USA", ")", "as", "described", "below", "using", "Cy3-labeled", "pre-miR", "and", "anti-miR-negative", "controls", "#", "1", "(", "ThermoFisher", "Scientific", "AM17120", "and", "AM17011", ")", "in", "3", ",", "30", ",", "and", "90", "nM", "final", "concentrations", "each", "or", "mock", "transfected", "." ] } ]
PMC9429973
The exposure of ITP MKs to selective RARα (AM580) or RARγ (BMS961) agonists did not change PPF.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "exposure", "of", "ITP", "MKs", "to", "selective", "RARα", "(", "AM580", ")", "or", "RARγ", "(", "BMS961", ")", "agonists", "did", "not", "change", "PPF", "." ] } ]
PMC9024365
The mean size of GluA1 puncta was significantly increased when stratified, indicating that co-localization with SD4 increases synaptic GluA1 cluster size during LTP.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mean", "size", "of", "GluA1", "puncta", "was", "significantly", "increased", "when", "stratified", ",", "indicating", "that", "co-localization", "with", "SD4", "increases", "synaptic", "GluA1", "cluster", "size", "during", "LTP", "." ] } ]
PMC11026382
TYMS R127A was not included in the deep mutational scan.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TYMS", "R127A", "was", "not", "included", "in", "the", "deep", "mutational", "scan", "." ] } ]
PMC11266100
Following a 20-min incubation on ice, the vial containing the precipitated DNA was centrifugation (31,840 × g for 15 min).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "a", "20-min", "incubation", "on", "ice", ",", "the", "vial", "containing", "the", "precipitated", "DNA", "was", "centrifugation", "(", "31,840", "×", "g", "for", "15", "min", ")", "." ] } ]
PMC11758416
Note: We used Dynabeads (Thermo Fisher Scientific) at a 5:1 (cell to bead) ratio to stimulate T cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Note", ":", "We", "used", "Dynabeads", "(", "Thermo", "Fisher", "Scientific", ")", "at", "a", "5:1", "(", "cell", "to", "bead", ")", "ratio", "to", "stimulate", "T", "cells", "." ] } ]
PMC11765879
Any floating cells were removed by washing with 1X DPBS (Dulbecco’s phosphate buffer saline) (Thermo Fisher Scientific).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Any", "floating", "cells", "were", "removed", "by", "washing", "with", "1X", "DPBS", "(", "Dulbecco", "’s", "phosphate", "buffer", "saline", ")", "(", "Thermo", "Fisher", "Scientific", ")", "." ] } ]
PMC10203589
FGF binds specifically to FGFR outside the cell membrane, inducing receptor dimerization, and then one of the dimers phosphorylates the other, which is called autophosphorylation of the receptor.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "FGF", "binds", "specifically", "to", "FGFR", "outside", "the", "cell", "membrane", ",", "inducing", "receptor", "dimerization", ",", "and", "then", "one", "of", "the", "dimers", "phosphorylates", "the", "other", ",", "which", "is", "called", "autophosphorylation", "of", "the", "receptor", "." ] } ]
PMC11627060
The zeta potential reflects the potential difference between the layer of dispersed particles surrounding electrophoretically mobile particles and their electric double layer at the sliding plane.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "zeta", "potential", "reflects", "the", "potential", "difference", "between", "the", "layer", "of", "dispersed", "particles", "surrounding", "electrophoretically", "mobile", "particles", "and", "their", "electric", "double", "layer", "at", "the", "sliding", "plane", "." ] } ]
PMC11787651
MS remains the only approach that is sensitive enough to differentiate between isobaric and coeluting modifications, as well as quantify hundreds of modifications in a single experiment in an extremely high-throughput manner compared with other approaches such as antibody detection (26, 27, 28, 29).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MS", "remains", "the", "only", "approach", "that", "is", "sensitive", "enough", "to", "differentiate", "between", "isobaric", "and", "coeluting", "modifications", ",", "as", "well", "as", "quantify", "hundreds", "of", "modifications", "in", "a", "single", "experiment", "in", "an", "extremely", "high-throughput", "manner", "compared", "with", "other", "approaches", "such", "as", "antibody", "detection", "(", "26", ",", "27", ",", "28", ",", "29", ")", "." ] } ]
PMC11247842
On BTA19, BTA19: 7,311,199 (rs110542780) is a tolerated missense variant for ENSBTAG00000038823, with a GERP score of 1.69.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "BTA19", ",", "BTA19", ":", "7,311,199", "(", "rs110542780", ")", "is", "a", "tolerated", "missense", "variant", "for", "ENSBTAG00000038823", ",", "with", "a", "GERP", "score", "of", "1.69", "." ] } ]