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OTAR3088
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BioData-CellLine_annotated

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PMC7334607
Using this map, we can see that the path toward collateral sensitivity or resistance is not always straight.
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PMC11574271
The weight of the tumor is shown in (C).
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PMC11747467
Silencing STAT3 increased the inhibitory efficacy of RC48.
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PMC11683240
Higher concentrations of α1AT (>50 μM) proved challenging to analyze in this assay, as they affected the protein migration in SDS-page (Fig. 4, C, D, F and G).
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PMC10976516
Chaurasiya et al.CoxsackievirusCoxsackievirus B3 (CVB3) strainIntratumoral, injectionsCVB3 was injected in a subcutaneous xenotransplant NSCLC (A549 or EBC-1 cells) model.
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PMC9874064
Subsequently, the effect of NP-Pt-USP1i on the clonony formation of BEL-7404DPP cells was further studied.
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PMC7887261
Lower o/e, in particular, the upper bound of the CI < 0.35 are indicative of strong intolerance (disease-causing).
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PMC9398137
Therefore, we hypothesize that MCL1 occupied by NOXA cannot provide effective anti-apoptotic protection both due to high turnover of MCL1-NOXA complexes and the inability to directly trigger apoptosis after exposure to S63845.
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PMC11721096
The excellent proliferation and protein expression capabilities of CHO cells make them an optimal choice for the expression of human tyrosinase.
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PMC11467800
The zebrafish larval model is used in this study to investigate the behaviour of phenotypically adherent, TKI‐resistant K562‐IR cells in terms of invasiveness/metastasis, angiogenic potential and population kinetics.
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PMC10538569
We next tested the effect of GPI-X5 on trans-infection using CEMss T cells modified to express CCR5 as target cells.
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PMC10006224
c Quantitative immunofluorescence (arb.
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PMC11757230
The mice received weekly injections of the same dose of cADSCs as the initial injection, and lymphoma cell growth was monitored over time using weekly bioluminescence imaging until the mice were sacrificed on day 22.
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PMC11754436
Comprehensive analysis identified DHRS4-AS1 as a ceRNA for miR-362-5p/NPEPPS in OS.
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PMC11610461
Additionally, PSENEN is not only involved in adipocyte differentiation but is also associated with neurodevelopmental diseases (Cheng et al., 2019).
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PMC11126803
Over the past few years, emerging evidence has implicated ZEB1 in drug resistance in multiple cancers (56, 57, 58), but it is unclear whether ZEB1 induced drug resistance is related to its direct promotion of VM formation.
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PMC9429973
Peptides with a log fold change >2 were considered as significant [log fold change: (number of DNA barcode reads associated with a specific pMHC)/3x (number of total barcode reads derived from the same sample)].
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PMC11536589
The MGST1 expression levels in MRTX1133-resistant PDAC cells treated with 1 µM LF3 or 0.2 µM PKF-118-310 for 48 h were measured by RT-qPCR detection. (
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PMC11560255
This percentage of cancer incidence causes sufferers to die at a high rate.
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PMC11576293
Yield 77%; m. p. 230–231°C; H NMR (300 MHz, CDCl3) δ (ppm) = 8.1 (overlap d.d.,
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PMC9031474
Particularly, the growing world population and increasing life expectancy will lead to a constant increase in cancer cases per year.
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PMC9429973
Methods: A retrospective analysis was conducted on 42 patients with TP53-MDS/AML who underwent allo-HSCT from 2006.1 to 2021.7.These patients may have deletion of the TP53 gene and/or mutations in the TP53 gene.
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PMC8348645
IC50value is calculated using Graph Prism software version 5.0 by nonlinear regression analysis of % inhibition recorded for different concentrations of test substances/standard and graph plot of concentration and % inhibition was done as shown in Figure 3.
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PMC11224020
Day 10 cells were stimulated with 100 ng ml LPS (Salmonella enterica serotype Typhimurium; Sigma) for 25 min, washed three times with complete medium, replated in fresh medium, left overnight in the incubator and used.
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PMC11794568
Proteins were denatured immediately prior to SDS-PAGE separation and transferred to polyvinylidene fluoride (PVDF) membranes (Pall Corp, Port Washington, NY).
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PMC11742670
Data analysis was conducted using the Graph Pad Prism Data Analysis software, employing multiple comparisons.
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PMC7334607
At the onset of the experiment, each cell line was split into eight evolutionary replicates, five experimental and three control.
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PMC11644761
Extracted RNAs were reverse transcribed using the SuperScript III First-Strand Synthesis SuperMix (Invitrogen, Thermo Fisher Scientific, Foster City, CA, USA) to obtain the relative cDNAs.
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PMC10900886
The inoculation of imDCs in the absence of BLCL resulted in production of new infectious virus particles (~1 logarithmic increase of TCID50/mL) within 24 h. Detection of infectious virus particles in the supernatants of the BLCL + DC co-culture showed a stably higher virus titer (~1–1.5 logarithmic increase of TCID50/mL) within the same period of time.
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PMC5673955
In present work, we studied the effect of RrA on telomerase activity and determination of lifespan of acute T‐cell leukemia Jurkat cells and normal human CD4 T‐lymphocytes.
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PMC11680562
Significantly, PXFCu6 demonstrated a consistent pattern of drug release from the beginning, persistently releasing the drug for 420 min.
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PMC11106977
Researchers have extensively studied the mechanism of protein O-GlcNAcylation over the past 30 years.
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PMC9920575
If so, it could serve as an adjuvant and complementary treatment, to increase the therapeutic efficacy of antineoplastic drugs and reduce the toxicity generated to the organs and, therefore, reduce the side effects derived from chemotherapy treatment.
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PMC11354239
In mesenchymal stem cells, the kinase c-KIT regulates the phosphorylation and activity of mTOR .
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PMC11367146
The molecular dynamic simulation was performed for top-docked complexes using the GROMACS package available in the SiBioLead LLC (https://sibiolead.com).
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PMC11756907
An appropriate dosage of GO-2-ME/rGO-2-ME, in which GO/rGO is a carrier of 2-methoxyestradiol (2-ME), can ensure effective penetration of the active substance through biological boundaries/membranes and controlled modification of cell signalling, ultimately leading to the selective elimination of malignant cells.
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PMC11679033
In view of all limitations, the open questions that remain should be a matter of forthcoming studies that should focus on other exposure scenarios and a much broader range of test concentrations, along with the application of sensitive biochemical methods able to document the impact of oxidative stress on the observed toxic effects.
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PMC8740518
Twenty female BALB/c nude mice (4-week-old) were purchased from Shanghai SLAC laboratory Animal Co., Ltd. (Shanghai, China) and acclimated for one week before experimentation.
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PMC11534035
Although the underlying mechanism connecting GPER1 and SERPINE1/PAI1 is not definitively proven, our findings reinforce the notion that these two cellular elements are related in gynecological cancers.
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PMC9429973
22.7% vs 7.4%, p=0.0169, Fig. 1D).
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PMC4695073
The protein concentrations in supernatants were measured using BCA Protein Assay Kit, proteins were then separated by 10% SDS-PAGE followed by transfer to PVDF membranes.
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PMC9812014
These precursors are transformed into a variety of core intermediates, which lead to the production of numerous alkaloids.
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PMC11752767
The assessment of TCR-T cell-related on-target off-tumor toxicity involves bioinformatic analysis of transcriptomic and proteomic databases, immunopeptidomics, and in vitro or ex vivo assays to evaluate the ability of TCR-T cells to recognize normal cells or tissues .
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PMC5673060
In this study, we utilise mass spectrometry to characterise the global phosphoproteomic alterations that accompany the acquisition of resistance to two FDA-approved TKIs, pazopanib and dasatinib, in the A204 rhabdoid tumour cell line.
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PMC11291490
The spleens were collected and the E protein was detected by immunohistochemistry assay.
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PMC8358176
Jurkat cells (a) untreated and (b) treated after 24 hours using MTT assay (scale bar=100 µm) The expression of TNF family molecules altered in SWCNT-COOH and MWCNT-COOH-exposed Jurkat cells, but not in the control cells.
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PMC11721277
The formation of a flaky precipitate was also observed.
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PMC11705862
We detected significantly decreased levels of secreted noradrenaline from cells in which all the CD59 splice variants were silenced (Fig. 3L).
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PMC11543935
A combination of spheroids and hydrogels could give a more complex and realistic in-vitro model where the limitations of each model alone can be overcome.
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PMC11687663
It was discovered that the protein’s grand average hydropathy value (GRAVY) was -0.170.
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PMC9219615
Additionally, Tpz-1 was noticeably less potent toward non-cancerous Hs27 cells.
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PMC11240052
Circ_0008285 enhanced SIRT-1 expression via sponging miR-211-5p in ovarian cancer cells. (
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PMC6487404
Based on their results OATP1B1 genotype was significantly associated with an enhanced effect of REG on blood glucose.
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PMC11477621
Data results were obtained from three independent experiments.
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PMC9848491
The ER separates, stores and releases calcium in cells, and is involved in regulating gene transcription in the nucleus, energy metabolism in mitochondria and cytoplasmic signaling pathways (20).
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PMC9429973
Undiagnosed patients may be referred to hematologists for thrombocytopenia/bleeding issues and splenomegaly.
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PMC11489351
Figure 2Transient changes in pHi lead to differentially expressed genes in normal epithelial cells.
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PMC11704834
At first, the levels of E-cadherin expression in A549 cells in the presence or absence of gefitinib were examined.
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PMC5916734
SDS-PAGE under reducing conditions, detection by polyclonal anti-FIX antibodies, the molecular weight of the marker bands is shown in kDa.
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PMC9910796
The present report provides evidence for the pivotal role of the previously uncharacterized inner envelope protein, pEP84R, in the assembly of the viral core.
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PMC5600151
This makes them promising structures for functionalization and also for conjugation with drugs and DNA/RNA.
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PMC7081114
Subsequently, after silencing KIF21B expression, the function of KIF21B in HCC lines was investigated by cell growth assay, MTT assay, fluorescence-activated cell sorting assay, and colony formation assay.
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PMC7185206
Tissue samples from consented human subjects were obtained as formalin-fixed paraffin-embedded blocks from clinical archives.
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PMC9429973
Aims: The aim of this study was to characterize the oncogenic role of MYCN in PTCL development, and to identify novel targets for therapy.
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PMC9429973
Demographic data, medical history, symptoms and signs, laboratory findings, chest computed tomography (CT) as well the treatment measures were collected and analysed.
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PMC9429973
At doses ≥ 200 mg, the ORR was 87.5%.
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PMC9429973
Summary/Conclusion: Our pre-clinical studies suggests that exploiting iron toxicity might be a valuable strategy to improve current target therapies in CLL.
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PMC10452486
The objective of this review is to chronologically trace (1) the discovery of B2m-free monomeric variants of HLA (Face-2) in normal cells, transfected cells, malignant cells, and activated immune cells; (2) the research documenting the cell surface expression of Face-2 independently of the B2m-associated HLA trimer (Face-1), as well as homo- and hetero-dimerization of Face-2 (Face-3 and Face-4); (3) the progressive research on the differences in the glycosylation patterns between Face-1 and Face-2; their peptide-binding capabilities; (4) their interactions with ligands such as KIR, hormones, and neurotransmitters; (5) their involvement in up- and downregulation of immune functions; (6) the possible role these variants in the pathogenesis of spondyloarthritis, human cancers, and in allograft recipients; and (7) the research on the phylogenetic relationship between HLA class I and II and the similarities of the amino acid patterns of the variants with other classes of HLA, which sheds new light on the origin of HLA during vertebrate evolution.
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PMC11406030
The safety of LMTK3BP #1, #2, and #3 was tested in athymic mice administered 2, 10, or 40 mg/kg by intravenous (i.v.)
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PMC9872547
The decrease in cervical tumor volume has also been demonstrated in the curcumin-treated mouse model (21).
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PMC7057940
no. ab4729) (all from Abcam).
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PMC11088135
F qRT-PCR was conducted to analyze the mRNA expression of Bcl-2. **
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PMC11185260
Quantification of tumor weight at harvest on day 43. *
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PMC11297139
The colors indicate normalized EWS/FLI1 ChIP-seq signal over the input signal.
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PMC9024365
Previously, we showed that SD4 alters AMPAR biophysical properties in a subunit-specific manner (Matt et al., 2018), indicating a direct and specific interaction with AMPARs.
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PMC11127909
B–D WB was used to detect BAX expression in the mitochondrial and cytosolic fractions of 143B-V, 143B-EFHD1, 143BR-shV and 143BR-shEFHD1 cells, N = 3.
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PMC11680391
Thus, from a business perspective, the dairy farmer should select a herd veterinarian who is skilled and capable of suggesting interventions to solve problems, focus on communication (Derks et al. (2012)) , and use communication methods like motivational interviewing for improved implementation .
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PMC11633763
Previous studies have shown significant changes in aerobic glycolysis in osteosarcoma cells .
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PMC9429973
One died of relapse of disease at +4 months after received HLA-haploidentical peripheral blood stem cell transplantation (PBSCT).
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PMC11696659
Analytical predictive models were developed using Random Forest from the dataset of telomere-associated variables (TAV).
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PMC11604015
But Oh et al. demonstrated that the TCR diversity and T cell subsets in patients treated with CD7 CAR-T cells were comparable to those in patients treated with CD19 CAR-T cells .
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PMC11078693
When 160 mL of permeabilization/quenching buffer is added to ∼23 mL of cells in 4% formaldehyde, the molar amount of Tris (0.032 moles) slightly exceeds that of formaldehyde (∼0.03 moles), causing fixation to be quenched.
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PMC11777207
Within these mutated DCs, denoted as Pdl1, similar amounts of endogenously expressed PD-L1 and CD80 were up-regulated upon LPS activation compared to WT DCs and the extracellular domain of PD-L1 remained completely intact (fig. S4).
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PMC11322866
Scale bar: 5 μm.
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PMC11697189
The OS rate and OS time of ccRCC patients in the high-risk group were significantly shorter than those in the low-risk group.
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PMC11487720
The tallness lasts less than 20 min, and then the cell divides.
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PMC10589262
In GIST cells, fluorescence signal of MT-KIT was barely observed at the plasma membrane (PM) without permeabilization, whereas a strong perinuclear fluorescence signal of MT-KIT was detected following permeabilization (Fig. 1A).
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PMC11629143
Thus, at least some copies of the CMV promoter have suboptimal acetylation of H3K27 in pools of cells with randomly integrated vectors.
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PMC5261804
This is consistent with our intuition of the locality of the essentiality score.
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PMC11155445
IIM surface chemically reacts with Ag ions through O and S of carbonyl and thiocarbonyl (169), respectively (Fig. 94).
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PMC11769522
In conclusion, the TNF-α/IFN-γ mixture induces the production of the pro-inflammatory cytokines and chemokines IL-6, CXCL8, and CCL2 by canine keratinocytes in vitro.
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PMC6450504
LSC permits the measurement of apoptosis based not only on cell morphology but also on cell staining for different apoptosis indicators, namely YoPro for early apoptosis (Figure 4(e,f) and Supplementary Figure S2(b)).
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PMC11657695
This study is the first to describe the involvement of KCNA2 expression and Kv1.2 channel in cancer development.
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PMC11711063
The amounts of DNA fragments associated with ARID1A or H3K27ac were normalized to input samples.
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PMC8662250
These effects, added to its known anti‐inflammatory properties identified at the lung level, are in line with other preclinical models of ARDS (Ribeiro et al., 2012; Salles et al., 2020).
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PMC11476666
When applied to spheroid cultures, both RSV and DHS significantly reduced spheroid production in SP and MP fractions, particularly in the preformation condition.
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PMC4659567
Many representatives of this type of ruthenium(II) organometallic complexes have been recently reported by several research groups as antitumor active against various human cancer cell lines (see Introduction) [14–22].
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PMC11055510
Ovarian cancer (OC) is the leading cause of death in women diagnosed with gynecological cancer (Penny, 2020; Yang et al., 2020).
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PMC11334037
Intriguingly, our study further showed that IGF2 regulates cellular sensitivity to imatinib by modulating glycolysis.
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PMC9096373
RT, radiotherapy; DDPs, cisplatin, APA, apatinib; microPET/CT, micro positron emission tomography/computed tomography. *,
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