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OTAR3088
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BioData-CellLine_annotated

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PMC6160470
Crown ethers are not P-gp substrates.
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PMC9429973
Y. Cai, J. Zhang, M. Yi, X. Liu, X. Zhang, Y. Wan, L. Chang, L. Zhang, X. Chen, Y. Guo, Y. Zou, Y. Chen, Y. Zhang, W. Yang, X. Zhu Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China Background: As a rare, aggressive pediatric myeloproliferative disease, juvenile myelomonocytic leukemia (JMML) encompassed both biological features of myelodysplastic syndrome and myeloproliferative neoplasm.
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PMC10978090
Note: In bold, the day of surgery.
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PMC9429973
The recommended first-line treatment is glucocorticoid therapy.
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PMC5535901
T cell receptor (TCR) activation is known to result in a rapid release of intracellular Ca which in turn stimulates downstream Ca-sensitive inflammatory signaling pathway .
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PMC8728081
The larger and agglomerated RS particles could not enter through the cell membrane; on the other hand, the smaller RS particles entered the intercellular cytosol and concentrated around the nucleus (Fig. 4e).
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PMC11640555
The results obtained reported a marked number of Ki-67 positive cells in the GBM mice (Figure 9A,A1 and score Figure 9D).
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PMC11754094
On the basis of the read alignment results, our programme categorizes the read pairs into three distinct classes: (1) all read pairs are skewed to the cleavage site, (2) all read pairs are mapped without splitting and the cleavage site passes between reads and (3) one of the reads is split and passes through the cleavage site.
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PMC11733919
The analysis of the levels of lysosomal marker Lamp1 was also considered using GFP-Lamp1 fusion protein and confocal imaging.
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PMC11434983
Li et al. (2020) synthesized copper complexes to assess the influence of PPh3 on anticancer activity.
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PMC9429973
Results: Sixteen patients with RR-AML participated in the study (15 evaluable for response).
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PMC11739670
Ligand‐bearing MR1 was purified by anion exchange and size exclusion chromatography and biotinylated using BirA ligase (Avidity).
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PMC10996034
CBP, DDP and DOX limit DNA replication and transcription via various mechanisms.
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PMC11628904
Dashed box indicates region of inset shown below.
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PMC10522430
This triggers the formation of the apoptosome and activation of caspase-3 .
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PMC11763126
Therefore, it is imperative to advance our comprehension of ccRCC pathogenesis and develop innovative therapeutic modalities to improve patient outcomes.
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PMC2944824
Cells were plated into 12 well plates and transfected with 400 ng of the p53 reporter gene plasmid (#16442 and 16443 as control Addgene, Cambridge, MA) and 400 ng CMV-β-galactosidase plasmid using calcium phosphate.
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PMC11285179
Importantly, chemotactic factors play a crucial role in cell migration, influencing not only the cell's movement but also closely interacting with cellular metabolism.
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PMC7039683
The significance of enrichment of each of the shared motifs among hOEAEs, mPEAEs and zPEAEs. (
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PMC9429973
Male:Female ratio was 1.3:1 in controls and 0.9:1 in patients (p˃0.05).
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PMC11361748
They are the first leukocytes to reach sites of tissue damage, infection, or stress, and are tasked with defending the host by releasing proteases and reactive oxygen species, phagocytosing pathogens and cell debris, and releasing genomic DNA-histone complexes known as neutrophil extracellular traps .
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PMC10900886
Statistical analysis was performed for every time point, but only virus titers at 48 hpi showed a significant difference.
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PMC11680562
In particular, apoptotic HeLa cells were visible in Fig. 9B, C and E. These apoptotic cells exhibited characteristic features such as shrinkage and a spherical shape.
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PMC11731161
We also conducted in vitro assays to validate the above results.
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PMC5308810
Interestingly, CXCR4 and CXCR4 that were physically isolated from A2780/ADR by flow cytometry was shown to spontaneously re-establish cell-state equilibrium.
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PMC10093184
This feature was previously described in several canine and human osteosarcoma cell lines, including D-17 and COS4288 cells .
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PMC6901583
d GIST882 and GIST-T1 cells stably expressing shcon or shBRD4 were cultured with DMEM without serum overnight.
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PMC11490153
ATR-FTIR spectrum of C. citratus-AlgNPs displayed the broadband at about 3238–3761 cm, related to OH groups, due to hydrogen bonding in EO, alginate, and water.
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PMC11593713
The oxidative stress index (OSI) was calculated as the percentage of TOS-to-TAC ratio .
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PMC10571053
Brain accumulation or oral bioavailability of FIN56, imidazole ketone erastin or piperazine erastin could similarly be affected, as they were found to be transported by P-gp.
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PMC8557138
The authors found that atorvastatin downregulated the expression of endothelial markers such as CD31, VEGF, and Bcl-2 and induced the expression of caspase-3 revealing its anti-angiogenic and apoptotic effect (Bayat et al. 2018).Organoid models have provided incredible scope for tumor modeling and pathogenesis, screening anti-cancer drugs, and personalized medicine.
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PMC11621565
The positive control (LDH max) represents the maximum LDH release after lysing the dopaminergic-differentiated neurons with 9% Triton X solution for 45 min.
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PMC11779993
Total RNA was extracted by using TRIzol reagent (Thermo Fisher Scientific, USA) according to the manufacturer's protocol.
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PMC11429241
This work demonstrated that a high count of microstructures destined for 3D cell formation can be produced in a short time.
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PMC11783017
Inspired by these concepts, cisplatin-loaded MnO2 was encapsulated into the IL11Rα-targeted liposomes and then incorporated into the ROS-responsive injectable hydrogels with NHWD-870 loading.
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PMC11413393
Second, abnormal R-loops are a widely recognized source of cellular stress and genomic instability, and may account for the accumulation of DSBs noted in this study.
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PMC7452526
In the current study, we investigated the anticancer potential against human colon cells (Caco-2) of colloidal nanosilver (CN–Ag) produced in Syria using bioactive compounds in the aqueous extract of Eucalyptus camaldulensis leaves (AEECL).
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PMC11026382
P values were calculated as in (a); the multiple-hypothesis testing adjusted p-value for the R166Q background was (P = 0.029).
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PMC10850553
Expression of C5ar1 in infiltrating neutrophils in IA lesions.
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PMC2944824
Although stress was observed as indicated by increased levels of both proteins, forced expression of Hr did not reduce the amount of stress.
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PMC10936243
So, we are not able to provide bedding for each one of them, as it will cost a lot…” [D081]. “
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PMC11012012
It was also expressed in EBV-positive (e.g., Raji) but not EBV-negative (e.g., Ramos) Burkitt lymphoma cell lines .
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PMC8735881
Alexa555-CtxB stands for the lipid raft marker GM1 stained with Alexa 555-conjugated cholera toxin B subunit; Alexa488-Anti-His stands for the transduced cells stained with mouse anti-His tag antibody followed by Alexa 488-conjugated goat anti-mouse IgG antibody.
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PMC11298021
Similarly, Shi et al discovered that FAK downregulation significantly increased rapamycin-induced decrease of cell proliferation, G0/G1 cell cycle arrest, and apoptosis, further supporting the idea that combining multiple components could yield more effective treatment outcomes.
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PMC9577200
The apoptosis rate was estimated by averaging the quantities of early and late apoptotic cells.
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PMC11155445
Novel naphthoyl thiourea derivatives were synthesized and evaluated for anticancer activity against human cancer cell lines HCT-116, MCF-7 and A549 in addition to normal cancer cell line MCF-10A.
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PMC11575040
When patients with melanoma do not respond to these therapies, substitutive or bypass pathways, such as the upregulation of the PI3K/AKT/mTOR pathway, are activated.
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PMC11785489
We concluded that the DNA-level excisions and insertions from V(D)J recombination are, in general, not sufficient to affect T cell state; recombination products must be expressed at the protein level.
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PMC10914904
Ectopic expression of vtRNA 2-1 decreases the interaction between HuR and the mRNAs of intercellular junction proteins, thereby suppressing cell proliferation in primary cultures of intestinal organoids and inhibiting intestinal mucosal growth in mouse models.
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PMC11470999
Cellular thermal shift assay (CETSA) was performed to assess the effect of PF on the thermal stability of CIP2A.
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PMC10748106
η=EHOMO−ELUMO2 (5)χ=EHOMO+ELUMO2 To construct our mathematical model, the multilinear regression by minimum quadratic differences was employed, using Excel Microsoft Office 365.
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PMC11720808
Cellular thermal shift assay (CETSA)-WB analysis of the interaction between SCU and TLR4. (
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PMC11779605
Hs.eg.db, which provides genome-wide annotations of the human genome.
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PMC11258145
A Langmuir trough (KSV, Finland) was employed to generate surface pressure isotherms.
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PMC11718274
After drying, the slides were immersed in a lysis solution for 10 min to lysis all cellular components except DNA.
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PMC6889484
Figure 3Replication Kinetics of Group M Viruses in CEM/D128K and PM1/D128K Cell LinesNormalized virus from subtype B (NL4-3), recombinant subtype AE, and subtype C (MJ4) virus and patient-derived subtype B isolates were used to infect parental and A3G-D128K-expressing T cell lines.
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PMC11543885
= 20 mM).
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PMC7802142
A heatmap analysis of miRNA expression levels was created based on the TPM values of miRNAs in ReN-NV and 293-NV (using TPMaverage > 1000, 1.5-fold change and P < 0.05 as the threshold cutoff).
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PMC7823217
Incubation of tissue spheroids in hanging drop cultures for long duration appears to stimulate tissue cohesion and maturation along with improved accumulation of ECM molecules .
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PMC11754784
Phagocytosis was analyzed using a CytoFLEX flow cytometer (Beckman Coulter).
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PMC11772585
In the past few years, extensive research in RNA biology has revealed over 160 posttranscriptional RNA modifications.
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PMC11528603
All dried extracts were weighed using analytical balances scales (Sartorius, Germany) and reconstituted with absolute DMSO (Merck, Germany) to prepare a stock solution.
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PMC11772585
Post-culture, the absorption at 450 nm was measured, and cell activity was calculated.
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PMC9429973
Change in lung high-resolution computed tomography (HRCT) scores for ground glass appearance is presented as LS mean ANCOVA absolute change from baseline.
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PMC7185206
To further characterize PD-L1 cleavage by ADAM10 and ADAM17, we labeled N-terminus surface PD-L1 on 786-0-PD-L1-GFP cells with Alexafluor-647-conjugated anti-PD-L1 antibody atezolizumab (ATZ-Alexa647) at time 0 and treated with DMSO vehicle control versus metalloprotease inhibitor TAPI-2 (Figure 2(b)).
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PMC7081114
Therefore, it is of great significance to determine the underlying mechanism of HCC to identify novel targets for the diagnosis and treatment of patients with HCC.
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PMC11739504
Gli1 was used as an activation marker of the Hh signaling pathway.
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PMC8956657
Consistent with the gel mobility shift assays, we found that MERS-CoV ORF4b bound to all IMPα isoforms tested (Fig. 1C and Supplementary Fig. 1).
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PMC8633974
Subsequently, treated cells were stimulated with 20 ng/mL TNFα (JLat 8.4 cells) or 50nM phorbol myristate acetate (PMA) (U1 cells).
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PMC11806818
The absolute value of the change in the peak current of DAP in the presence and absence of CEA (ΔIp) was selected as the correlation output signal, and there was a linear relationship between the value of ΔIp and the concentration of CEA in the range of 0.003 − 15.0 ng/mL, with a limit of detection of 1.0 pg/mL. This nanozyme-based voltammetric sensor has a better performance for the detection of CEA in the realizing simple, sensitive and efficient CEA determination with great potential.
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PMC11787355
All cell lines were incubated at 37 °C and 5% CO2 with saturated humidity.
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PMC9429973
Summary/Conclusion: In this real-world data analysis, history of thrombocytopenia was a major factor influencing the RUX dose for treatment of MF pts, consistent with prescribing data that RUX dose is adjusted based on platelet counts.
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PMC11468365
It contains data on 38 unique drugs and their interactions, resulting in a large number of drug combination pairs tested across 39 cancer cell lines.
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PMC11680982
This was achieved by using HR/HER2-low cell lines with low HER2 expression.
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PMC11705547
FASN inhibitors blocked the FASN-HIF1α-SLC7A11 pathway signaling in hepatocellular carcinoma cells, and delayed tumor growth by inducing apoptosis and necrosis .
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PMC11064533
It has also been reported that a strong relationship exists in E. coli between motility, flagella, and biofilm architecture (50, 51).
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PMC9429973
Neutropenia and infection were the most common TEAEs for any grade (71% and 59% respectively) and grade ≥ 3 (59% and 29% respectively).
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PMC9429973
Patients neither deceased nor receiving a 2-line therapy within 3 years after 1-line therapy were defined as patients in remission.
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PMC9429973
The knock-down of PD-1 and TIGIT at CD19 CAR-T cells exerts the superior T-cell functionality by delaying the exhaustion of CAR-T cells.
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PMC4839679
Though the precise molecular mechanism is unknown, the increased accumulation in cholesteryl oleate (CE18:1) and decreased accumulation in cholesterol linoleate (CE18:2) has been characterized in ccRCC .
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PMC10778532
Therefore, the VHL-C162F-induced upregulation of EMT markers may presumably help the cells to gain migratory and invasive traits.
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PMC10747139
In vivo experiments showed that 48lipo could prevent tumor growth in a concentration-dependent manner with a high inhibitory rate (53.53% and 72.90% for 1.23 mg/kg and 2.46 mg/kg of 48lipo, respectively).
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PMC11682172
This cell line overexpresses Her2 and is a preferential model for Her2 positive breast cancer with metastatic potential without organ-specificity.
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PMC9596868
Cell viability after 72 h treatment with quercetin (5, 10 and 50 µM) or MST-312 (0.5, 1 2 and 5 µM) was determined by performing alamar blue assay using DMSO as vehicle control. (
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PMC11656657
After 72 h (hrs), the conditioned medium (CM1) was collected, filtered through a 0.4 µm filter, and stored at −20 °C.
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PMC8839885
Thus, 2HE2 and dasatinib might act as sensitizers to restore platinum drug sensitivity to OC cells and thus to limit TME-mediated chemoresistance in OC.Chemoresistance is frequently encountered in ovarian cancer (OC) patients treated with platinum-based chemotherapy.
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PMC11394227
In the ER of CHO cells, the oxidation capacity of molecular oxygen is utilized mainly by protein disulfide isomerase (PDI) and endoplasmic reticulum oxidoreductase 1 (Ero1) to generate new disulfide bonds in the newly folded protein .
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PMC11277157
Lipo2000 was shown to be ideal for HEK293 .
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PMC11787381
BRET curves and area under the curve (insert) are presented.
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PMC10988555
The samples were centrifuged for 5 min at 700 × g and resuspended in fresh lysis buffer (150 mM NaCl, 5 mM ethylenediaminetetraacetic acid (EDTA), 50 mM Tris–HCl at pH 8.0, 2% (v/v) NP-40, 1× phosphatase inhibitors (PhosStop, Roche), 1× Protease inhibitors (complete ULTRA tablets, Mini, easypack, Roche), 1 mM phenylmethylsulfonylfuoride (PMSF) and 0.1% 1,4-dithiothreitol (v/v), DTT) and then storage at −80 °C for 2 h or until required.
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PMC11545868
This cell death is characterized by a highly regulated program of cell shrinkage, condensation of nuclear chromatin, fragmentation of DNA, and formation of the apoptotic body .
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PMC7961460
After 48h, NHDF cells were harvested for RNA in TRI Reagent to study HASes gene expression.
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PMC6461034
For the eight samples considered (four cell lines of Fig 2 and the four U87 conditions of Fig 5A and B), the highest rank for the driver kinases was either equivalent or better for uncorrected INKA score calculations.
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PMC11774747
The HERT-GBM trial also showed successful manufacturing of 16 products for all the treated patients.
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PMC9874064
The establishment of a PDX model of liver cancer on nude mice and the schematic schedule of drug administration.
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PMC5839394
On the other hand, Ag binds to proteins and DNA, interfering with their functions .
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PMC11306019
A vicinal diol is a chemical group with two hydroxyl groups on neighboring carbon atoms in a molecule.
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PMC9429973
Clinical and hematological monitoring with the study of bone marrow apirate will be required at regular intervals for the early recognition of this phenomenon.
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PMC9429973
CLL killing was evaluated in a similar co-culture, but with a staining mix containing CD5 and CD19, to identify CLL tumor cells in order to determine the percent CLL targets killed normalized to incubation of CLL cells with NK cells alone (Figure Image).
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PMC11757131
The cell nuclei were stained with hematoxylin for 10 min and rinsed.
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