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PMC11772449
These mechanisms in turn represent important molecular targets for the development of new drug therapies (Jindal et al., 2019).
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PMC9429973
However, they are characterized by modest selectivity and/or limited central nervous system (CNS) penetration.
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PMC10551595
The binding energies calculated between GinA and Caspases9, 3 and 8 were −6.76, −6.12 and −6.64, respectively (Table 3).
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PMC11534035
Cell viability in SERPINE1/PAI1 knockdown and siRNA control cells, in the A431 (C) and CAL39 (D) cell lines.
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PMC11025866
In cells treated with the HDAC inhibitor, sodium butyrate (NaB), 605 genes were expressed significantly (adjusted p-value < 0.1) differently than untreated cells; 308 genes were upregulated (log2-fold change > 0) and 297 genes were downregulated (log2-fold change < 0) compared to untreated cells (Table 1).
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PMC2614416
Catalytic activity DAG of the HepG2 proteome.
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PMC11592008
To compare the expression and function of components of the NLRP1 inflammasome in different keratinocyte cell lines, we first analyzed the expression levels of key inflammasome molecules in HaCaT, HaSKpw, SVTERT, and PK cells at both the mRNA and protein levels.
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PMC11694625
Based on these facts, supported by our ongoing research for new anticancer agents, a series of new quinoline-based dihydrazone derivatives (3a–3d) linked by pyrimidine skeleton were designed, synthesized and investigated for their anticancer properties.
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PMC8097906
and the control were used for continuing cell motility examinations (Fig. 2a).
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PMC11301242
Upon comparison, the results remained consistent with previous findings (Fig. 4B, Supplementary Fig. 3A), which suggesting that chromatin of circular amplicons was more accessible compared to the same locus that were non-circularly amplified.
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PMC11291490
Following this, the cells were subjected to incubation with rabbit anti-duCD40L polyclonal antibody (prepared in this study, 1:250) or rabbit anti-E polyclonal antibody (prepared in this study, 1:500) at 4 °C.
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PMC11794847
Oxygen consumption rate (OCR) in activated Jurkat cells was assessed using a Seahorse XFp Analyzer, a widely recognized instrument for such evaluations.
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PMC11515150
To address the drawback, T cells were transduced with the second-generation CD5 CAR mentioned above which was linked to amino acid sequences encoding ER retention, referred to as 5D.b CAR-T and 12 C.b CAR-T (Fig. 2b).
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PMC11756907
Thus, preferably, the GO-2-ME or rGO-2-ME can be used for the local treatment of tumours, in particular malignant melanoma or other tumours of the skin and mucous membranes.
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PMC11453018
F Gross morphology of tumors from treated (iP300w, 5.6 mg/kg daily) and control mice at the terminal point of the experiment (day 14).
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PMC11472569
Several tetra-transmembrane proteins (e.g., CD9, CD37, CD81, CD82, and CD63) are particularly abundant in exosomes and microvesicles.
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PMC11490153
One-way ANOVA, followed by Tukey’s post hoc test with a P value of 0.05, was used to compare the flow cytometry results.
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PMC10391797
To improve the therapeutic effect and overcome immune escape, we tested the combined CAR-T cell therapy with HDACi and programmed cell death protein-1 (PD-1) or its ligand PD-L1 antibodies to treat AML.
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PMC11391695
We present compelling evidence in this study that ACYP2 functions as a tumor suppressor gene in HCC.
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PMC11126803
We used multiple RCC cells and an in vivo mouse model for our study, and results indicated that LncRNA-SERB could boost RCC VM formation and cell invasion in vitro and in vivo.
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PMC11615101
The bar graph represents the fold change of α-Taxilin expression based on densitometric values of WB after knockdown using 25nM and 50nM Si-RNA induction and 20ng/ml TNF-α induction along with non-specific Si-RNA control. (
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PMC11711063
Gene ontology analysis of functional changes in response to ZG16B. (
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PMC9681981
The experimental factors included two differently treated bacteria (contact with Caco-2 and non-contact with Caco-2) and 3 different harvesting times (0, 2, and 5 h post-exposure).
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PMC8009078
All molecules were found to be high penetrable to the gastro intestine.
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PMC11381192
Univariate analysis showed that high CSI was associated with inferior prognosis (HR: 2.718, p < 0.001), and multivariate analysis confirmed that CSI level could be an independent risk factor for OS (HR: 2.236, p < 0.001).
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PMC11596967
These short leaderless transcripts can be potential templates for synthesizing peptides.
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PMC11188874
To investigate the mechanistic role of HDAC6 in modulating proteasome activity, HDAC6 was targeted in three MMCLs by CRISPR/Cas9 editing and target gene KO was confirmed by Western blot analysis (Fig. 5A).
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PMC11706776
It can be noted that KCNN1 silencing by a pool of siRNA against KCNN1 also leads to an increase in cell sensitivity to doxorubicin (Supplementary Fig. 6A).
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PMC7917457
For the NY-ESO-1 assay, CD8 T cells were presensitized with tumor antigen-containing peptides, with or without polylysine modification.
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PMC9429973
It is known from the case history, that he had been vaccinated against SARS COV2 with one of the Russian vaccines one months before admitting to our clinic.
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PMC9429973
Here we present the latest PRIMO Expansion Phase (EP) data.
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PMC11753435
In two-thirds of cases, SS18 is fused to the SSX1 gene (45).
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PMC11471176
An example is provided here; to detect a difference in expression (fluorescence) at a comparable dilution for carnosine and DMSO of 1600 and 2200, respectively, and assuming the standard deviation of measurements would be 250, we would need 3 measurements in each group giving us a power of 80 % to detect a statistically significant difference at the 0.05 alpha level of significance.
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PMC11225860
Bárbara De La Peña Avalos: Investigation, Data curation.
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PMC9429973
MicroRNAs (miRNAs) are a class of small (19-25 nucleotides), endogenous RNA which play a significant role in regulation of gene expressions.
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PMC11597291
The effect of PEG characteristics on particle size and surface charge, colloidal stability, drug, and release, and the hemolytic potential of nCGO, was investigated.
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PMC8623816
Gene AG1IA_06216 and gene AG1IA_06615 were predicted to encode a hypothetical protein, respectively.
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PMC8345486
The cells were incubated for 48 h with the compounds (0.01–200 μM).
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PMC9429973
Prospective studies are needed to uniform the therapeutic approach and to identify variables capable of predicting outcome and to guide therapy.
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PMC11055323
Data are mean ± s.d.,
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PMC11718109
Fixed agarose blocks were incubated with 10 mM Tris-HCl buffer (pH 7.4) for 30 min to quench unreacted aldehyde groups.
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PMC11706776
A KCNN1 expression in A-673 cell line stably transduced with doxycycline-inducible shRNA control cells (shRNA CT) or 3 shRNA cells targeting KCNN1 (shRNA 511, shRNA 908 and shRNA 576) after 72 h of treatment with doxycycline (0.5 µg/mL).
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PMC11592008
qPCR was performed using KAPA SYBR FAST (Cat # KK4617; Merck KGaA).
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PMC5417661
Ovarian cancer (OC) is the leading cause of death among all gynecologic cancers.
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PMC11768281
These findings underscore the importance of NKT cells not only in the innate immune defense but also in the modulation of adaptive immune responses against malaria and other intracellular pathogens.
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PMC6835428
Loading the particles with an anti-luciferase siRNA (luc-siRNA), the authors observed that at the concentration of 200 nM luc-siRNA and at a nitrogen/phosphate (N/P, polymer/siRNA) of 16, PVTC/luc-siRNA particles were the most effective in reducing luciferase expression (60% reduction) compared to control.
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PMC11697065
Indeed, previous work focusing on such “difficult-to-express" (DTE) proteins reveals genetic adaptations involved in apoptosis and protein degradation processes such as endoplasmic-reticulum-associated protein degradation (ERAD) as important for DTE antibody expression.
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PMC11496728
These results indicate that the proportion of apoptotic cells in CHO cells with Apaf1 knockout is lower than that in CHO-WT (Fig. 5E).
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PMC11698348
RT-qPCR analysis during calcium (Ca2)-induced (low: 0.05mM or high: 2.0mM) keratinocyte differentiation in PMEKs, showing an increase in the expression of keratinocyte differentiation-associated markers cytokeratin 1 (Krt1), Krt10, and Involucrin (Ivl) and Elf5, respectively.
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PMC11525293
We found that Thal pretreatment impairs pseudoviral infection in vitro, as evidenced by reduced GFP signals in the Thal-pretreated samples compared with the controls (Fig. 4B and C).
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PMC11377827
Source data are available online for this figure.
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PMC9429973
Summary/Conclusion: Teclistamab significantly improved efficacy over sel-dex for all outcomes except PFS (though numerically in favor of teclistamab) in this MAIC.
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PMC11748335
This infers that genes associated with the loss of short LOCKs in tumor cell lines may either remain suppressed due to promoter hypermethylation or become activated through regulation by active histone modifications.
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PMC3734024
Specifically, FasL B cells are moderately enriched in the CD5CD1d B cell subset, but only a minority of FasL B cells is found within this B cell subset.
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PMC9429973
With the significant advancement in therapeutic modalities the overall survival of this affected population has increased significantly.
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PMC9429973
This study compared and analyzed the efficiency of high-throughput sequencing and Sanger sequencing in detecting ABL kinase region mutations, further clarified the clinical value of high-throughput sequencing in detecting low proportion mutations and multipoint mutations in ABL kinase region, and provided basis for TKI precision treatment.
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PMC9429973
The first dose of obinutuzumab is divided into 100 mg on day 1 and 900 mg on day 2 of cycle 3; 1000 mg are given during subsequent cycles (cycles 4-8).
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PMC11648299
Data from the Swedish Cancer Registry was available until December 31, 2019.
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PMC10203589
These effects were also confirmed with FGFR2 depletion, knockdown, or the use of FGFR inhibitor AZD4547 (51, 52).
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PMC8632470
A study on the effect of chalcone derivatives on D-galactosamine/lipopolysaccharide-induced liver failure in mice has confirmed a strong hepatoprotective activity of those compounds .
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PMC11741906
The yellow color indicates the target genes that are targeted by one of the miRNAs, the orange color indicates the target genes that are targeted by more than one miRNA, and the green color indicates the rest of the pathway genes that are not targeted by the studied miRNAs.
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PMC11543885
To ensure the normal biological function of NLRP3 and enzymatic activity of APEX2, we insert APEX2 to the C-terminus of NLRP3 with an appropriate linker between them, and flag tag to the N-terminus for western blotting and immunofluorescence.
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PMC10761218
The aforementioned data suggest a heightened efficacy of the methanolic extract derived from W. somnifera leaf in inhibiting the proliferation of the Hep G2 cell line.
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PMC9895440
The pool was quantified by Fluorometry using the QuantiFluor ONE dsDNA System (Cat# E4871, Promega, Madison, WI, USA).
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PMC11495567
While the presence of KRAS mutations may be similar in Blacks and Whites, other associated genetic factors may influence responses to various therapeutic agents.
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PMC9927933
The proportion scores of indicated protein expression depending on the percentage of positive cells were classified as follows: 0, 0%; 1, ≤10%; 2, 11%–50%; 3, 51%–80%; and 4, ≥81%.
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PMC11727306
The results (Figure 1) show that there is a strong negative relationship over three logs between abrin concentration and GFP expression: The level of GFP expression was reduced in a dose-dependent manner after treatment with abrin toxin for 24 or 48 h at concentrations of 0.1 pg/mL, 1 pg/mL and 10 pg/mL. Above 10 pg/mL abrin toxin concentration, GFP inhibition reached a plateau.
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PMC10976516
Contrary to this, myxoma virus tropism for all SCLC subtypes is not hindered by the need for a specific cellular receptor and preclinical results of its use against SCLC PDX as well as syngeneic murine SCLC models showed significant tumor clearance.
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PMC11394730
QUE is primarily found in plants as glycosides.
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PMC11186948
In addition, she presented vertebral anomalies, hypoplasia of corpus callosum, hypermetropia and early puberty (Table 2).
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PMC11670407
This finding is consistent with the results of previous in vitro experiments.
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PMC11803918
Hybrid exosomes had high biocompatibility with red blood cells during circulation (Figure S6).
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PMC11707832
A comprehensive investigation into MAN2B1-related research is anticipated to significantly advance our understanding of the pathogenic mechanisms underlying α-mannosidosis, potentially opening avenues for more diverse and effective therapeutic strategies.
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PMC11754436
The CCK-8 assay was employed to determine the proliferation and apoptosis levels of MG63 cells co-transfected with miR-362-5p mimetics and NPEPPS, *Represent comparison with the NC group. (
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PMC9429973
There are no data of the prospective two-step dose reduction trials of different TKIs followed up with TFR observation.
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PMC10006224
d Changes in total and salt-resistant chromatin-bound levels of STAG1 and STAG2 in G1 cells after NIPBL KD (n = 4 experiments) or CTCF KD (n = 3 experiments).
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PMC11173119
IPSCs were obtained by overexpression of reprogramming factors OCT4, KLF4, L-MYC, SOX2, LIN28, and mp53DD using a set of episomal vectors (ID Addgene #41855–58, #41813–14) as described previously .
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PMC10882807
Total RNA was isolated by TRIzol reagent (Invitrogen, USA) and the concentration of total RNA was detected by NanoDrop spectrophotometer (Thermo Fisher Scientific, USA).
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PMC11377827
Additionally, while our findings support phosphorylation as the signal for the association of USP43 with 14-3-3 proteins and HIF-1α, what drives this phosphorylation in hypoxia warrants further exploration.
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PMC7812570
Therefore, the present studies have provided a potential HIV-1 gene therapy approach that can be used alone or in combination with other strategies.
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PMC8382973
Effects of different concentrations of HEC gel on TZM-bl cell viability.
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PMC9429973
The more severe GVHD grades were associated with higher NRM with HRs for acute GVHD grade III-IV and extensive chronic GVHD of 1.95 (1.09-3.48, P=0.0024) and 3.3 (1.41-7.73, P=0.006), respectively.
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PMC10165258
Viability quantification of EwS spheroids related to drug concentration using the microfluidic protocols.
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PMC9429973
The mean number of days spent in the ICU was 16 (13-18) days.
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PMC4839679
Cytoskeletal reorganization was induced upon PBRM1 reexpression as evidenced from the increase in the number of cells displaying cortical actin, a hallmark of epithelial cells.
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PMC10178190
Chemoresistance is frequently encountered in OC patients, consequent to multiple mechanisms, including decreased platinum accumulation within the cancer cells, elevated drug inactivation by metallothionein and glutathione, and enhanced DNA-repair activity .
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PMC7823217
Among the subtypes of ovarian cancer cells, epithelial tumors are known to have low malignant potential; this subtype is more common in young women.
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PMC11001582
GFP levels were measured by the GFP ELISA Kit (ab171581, Abcam) according to manufacturer’s instructions.
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PMC11803149
Aged CD8 TCR-T cells are prone to become Tex-like cells in tumors. (
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PMC10988555
After drying at 4 °C for 15 min, the slides were dipped into lysis solution (450 mM NaCl, 3.72% EDTA, 5 mM Tris; to which 10% (v/v) DMSO and 1% (v/v) Triton-X were added just before use) for 1 h at 4 °C, followed by their being dipped for 40 min into cold electrophoresis solution (1 mM EDTA, 300 mM NaOH, pH 13).
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PMC11095939
p<0.0001 by two-way ANOVA. (
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PMC3675084
In contrast, the survivin expression was depleted in the OVCAR-3-TR and SKOV-3-TR sublines, BPR0L075 treatment failed to induce survivin up-regulation in the paclitaxel-resistant cells (Figure 5A, B).
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PMC11756907
Phosphatase hydrolyses pNPP to p-nitrophenol and inorganic phosphate.
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PMC9118379
We suggest that postexaminations of identified variant events are essential and can be considered as additional guidelines to evaluate the reliability of variant events in proteogenomics studies.
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PMC10882807
The bands were visualized by an enhanced chemiluminescence detection system (Tanon, China).
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PMC11732628
The 143B cells were inoculated into 96-well plates and then incubated in DMEM (Gibco; Thermo Fisher Scientific, Inc.) with 10% FBS (Gibco; Thermo Fisher Scientific, Inc.) for 24, 48, and 72 h. CCK-8 solution (10 µL; Beyotime Institute of Biotechnology; Shanghai, China) was added to each well and the cells were incubated for an additional 2 h. A microplate reader (Thermo Fisher Scientific, Inc.) was used to detect the optical density at 450 nm.
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PMC6268318
In the case of compounds obtained from C. molle, the analgesic and antiinflammatory properties of mollic acid glucoside (MAG) (Figure 1H), a 1α-hydroxycycloartenoid extracted from Combretum molle leaves, have been investigated in mice and rats .
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PMC11411131
Cos-7 cells were transfected with pCT-Luc and Krab-Sec (or Krabx2-Sec) and subsequently subjected to a luciferase assay. (
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PMC9429973
Since 2012, chemotherapy eligible patients are treated following a risk-adapted and MRD-guided protocol in the CETLAM group (AML-12).
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PMC4659567
Ru(η -p-cym)(5Braza)Cl2] (4): Anal.
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