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OTAR3088
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BioData-CellLine_annotated

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PMC11411131
The cells were cultured in Advanced Dulbecco’s Modified Eagle Medium (Thermo Fisher Scientific, Waltham, Massachusetts, United States of America) supplemented with fetal bovine serum.
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PMC6133382
The excess of dichloromethane was removed by stream of nitrogen and subsequently prepared for MALDI-MS analysis .
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PMC9014716
In recent years, especially following the approval of sorafenib by the Food and Drug Administration, the advent of targeted therapy and immunotherapy has greatly improved the survival of patients with HCC.
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PMC10988555
In what concerns the formation of new vessels, complexes 2–4 do not seem capable of inducing an angiogenic process, which is a promising issue.
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PMC9429973
All pts in VC1 received imatinib as upfront treatment.
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PMC11755519
Nanomechanical analysis showed a marked reduction in the stiffness of exosomes from malignant cells compared to exosomes from control cells.
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PMC11806818
A comparative analysis of single-mode versus dual-mode sensors targeting the same biomarker reveals that dual-mode sensors can achieve lower detection limits and maintain a broader linear range.
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PMC10900886
For co-culture assay, infected imDCs (1 × 10 cells/well) as describe above were incubated with (2 × 10 BLCL/well; BLCL + DC) or without autologous BLCL (DC only).
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PMC9429973
These data strongly support that T22-PE24-H6 may obtain therapeutic benefit for AML patients with high CXCR4 expression.
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PMC8193046
Ligand-based retrospective approaches are much less present in literature and have been described, for example, for ABCB11 , , , or ABCC2 .
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PMC10748106
This information is employed for the discovery of new structurally different drug candidates or for the optimization of lead compounds.
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PMC6461034
The table is filtered for the top 20 kinases with the highest aggregated “phosphosignals”.
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PMC9429973
This study was approved by the Ethics Committee of Beijing Hospital, National Center of Gerontology, Beijing, China.
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PMC9429973
Methods: PEGASUS enrolled adult patients with PNH with prior suboptimal response to eculizumab (ECU) despite stable ECU treatment (≥3 months) and hemoglobin (Hb) levels <10.5 g/dL at screening.
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PMC11026382
Dotted lines indicate linear regression fits to each replicate, the slope of each line is the inferred growth rate (relative to WT) for that DHFR/TYMS mutant combination.
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PMC11750712
IF biopsy imaging is shown in Fig. 3.
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PMC11473843
Tet-pLKO-puro (Addgene Plasmid #21915, https://www.addgene.org/21915/; RRID:Addgene_21915) was a gift from Prof. Dmitri Wiederschain (Wiederschain et al, 2009).
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PMC11769516
and was established by the EFSA Panel on Contaminants in the Food Chain in 2011.
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PMC9712534
A previous study showed that TOP2A harboring either T48I or Y49F in CHO cells exhibits ICRF resistance.
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PMC11700247
A total of 2 × 10 of A20 tumor cells were injected subcutaneously in both sides of mice, and 19 days later, 1 of the 2 tumors was irradiated with either 8-Gy × 1 fraction or 4-Gy × 2 fractions on consecutive days (Figure 1A).
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PMC10587429
For non-humanized mice with tumors, via intraperitoneal injection, administer 100 μg/animal of IgG or magrolimab every day on Days 4 to 10.
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PMC7642379
Furthermore, we focus on transcriptomic differences between adherent and suspension HEK293 cells and the impact of the differentially expressed genes on metabolic pathways and the phenotype of the cells from a bioprocess perspective.
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PMC8348645
Presence of reddish brown colour at the interface would show the presence of terpenoids.
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PMC11754094
Inhibition of the MMR pathway did not significantly affect the frequency of large-deletion events compared with those induced by PE3 with pegRNA (Fig. 5c), suggesting that the MMR pathway has a low contribution to the occurrence of PE3-mediated large deletions.
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PMC11098378
HopT1-2 has also been implicated in suppressing plant immunity.
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PMC11804588
The authors also used FOODIE to study the pairwise TF binding patterns on DNA, which can be either positively correlated (cooperativity) or negatively correlated (exclusivity) (20).
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PMC10502403
In cultures without cytokine supplementation, cell growth of PTA-treated γδ-T cells was suppressed (Figures S4A and S4B).
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PMC7136814
Specifically, at the highest Vincristine treatment dose, the proportion of MYOD1+ NOG+ increased 2.4 times (p < 0.001) and 5.9 times (p < 0.05) for RD and A-204, respectively (Figure 1(b), top panel).
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PMC11700165
Despite a high degree of conservation between the N-terminal region of ITK and BTK, subtle characteristics may still result in functional differences.
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PMC11457557
These medications inhibit the renin–angiotensin–aldosterone system (RAAS) and reduce the risk of complications .
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PMC10877303
Later, a fusion core, which is a six-helix bundle (6-HB), is formed by attaching HR2 with HR1, bringing the cell and viral membranes into close proximity for viral fusion .
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PMC11509309
Here, we confirmed the anti-prion activity of purealidin Q (1), aplysamine-2 (2), and aplysamine-1 (5) against [PSI+] and [URE3] yeast prions and showed that these three bromotyrosine derivatives are potent anti-PrP compounds.
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PMC11768927
Its replication is severely limited in normal tissues that contain intact IFN responses.
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PMC11656657
At the tumor engraftment, i.e. when the tumor's bioluminescence was detectable and measurable by the IVIS imaging system, mice were randomized to receive either control NT-T-cells or CAR.GD2 T-cells.
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PMC9429973
Particularly, the low VAF of DNMT3A gene in cases #6 and #7, both patients without evidence of BM lymphoma involvement, is strongly suggestive of CH promoted by IBD.
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PMC11615218
T cells are the main adaptive immune cells against tumors and serve as the cellular basis for CAR-T cell therapy.
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PMC9429973
This endocytosis would facilitate the Hb clearance during a massive hemolysis?
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PMC11721277
Renal retention was within a reasonable range from 3%ID/g to 5%ID/g.
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PMC9847912
Additional support for a direct physical association between bevirimat and CA-SP1 was obtained in a cross-linking study using HIV-1 cores and a photoaffinity-labeled analog of the inhibitor .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "support", "for", "a", "direct", "physical", "association", "between", "bevirimat", "and", "CA-SP1", "was", "obtained", "in", "a", "cross-linking", "study", "using", "HIV-1", "cores", "and", "a", "photoaffinity-labeled", "analog", "of", "the", "inhibitor", "." ] } ]
PMC9429973
Results: Patient H198302 and Patient H198303 both had CMML and had been treated with AZA for ~10 years with complete response.
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PMC10547921
Compound 99 is conjugated to the anti-TNF mAb using a dipeptide-based protease (Ala–Ala) cleavable linker, and the resulting conjugate is only weakly active in cell-based evaluation (IC50 = 8.1 μmol/L).
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PMC11782780
BC cells transfected with oe-EBF3, sh-EBF3, miR-301b-3p mimic, and treated with glycolysis inhibitor 2-deoxy-d-glucose (2-DG) (MCE, Monmouth Junction, NJ), 3-Bromopyruvate (3-BP) (Merck, Darmstadt, Germany) were plated into a 96-well plate (100 ‍μl/well medium).
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PMC11180402
Data are mean ± SD from triplicate samples. *, #,
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PMC11228511
Because the SMC clones were grown in Dox-free medium, we were able—by adding Dox to the medium—to examine the impact of progerin expression in naive SMCs.
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PMC9164404
C Intracellular Pt uptake of the cells treated with various drugs (10 μM Pt) for 1, 4, and 7 h respectively via ICP-MS.
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PMC9429973
The combination of various doses of CHI with either IC50 or 1/2 IC50 of 2-CdA significantly decreases the survival rate of U937 cells compared to single drug control (Fig.1a).
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PMC3681794
B, Western blotting performed on cell lysates from cells simultaneously maintained in hypoxia shows reduced expression of HIF-1α and CA IX, indicating suppressed transcriptional activity, throughout the experiment.
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PMC11541241
Further experiments revealed that the TOR pathway was linked with the STRIPAK complex through the TAP42‐PP2A cascade.
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PMC11706491
Growth rate was measured using the straight-line tool from Fiji when cells were under growth time (considered as non-septating time).
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PMC4485648
Cells treated with 2.5, 5 and 10 μM concentrations of SFN were subjected to flow cytometric analysis to assess their viability.
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PMC9429973
Since age is a variable deeply associated with survival in AML, we evaluated the performance of the models including this covariate.
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PMC9429973
17 (33%) patients required hospitalization of which all (33%) of them required oxygen supplementation.
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PMC10813895
ELF5 expression is nearly suppressed in three kidney carcinoma subtypes .
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PMC11678841
α-Tocopherol (1667600) was purchased from Sigma-Aldrich (Sigma-Aldrich, St. Louis, MO, USA), and garcinoic acid (GA) was extracted from Garcinia kola seeds as reported in .
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PMC11536589
AsPC1-MR cells showed different biological capabilities from AsPC1 cells (Table.
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PMC9429973
Key eligibility criteria include patients with metastatic or unresectable disease that have progressed after prior therapy and for whom standard therapy with proven clinical benefit does not exist, is no longer effective, or is not appropriate.
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PMC4270159
Treatment of the cells with the secondary kinase inhibitor alone.
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PMC6461034
For the four oncogene‐driven cell lines, INKA outperformed KARP in assigning high ranks to the known drivers (Appendix Fig S7).
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PMC11511922
Scale bar indicates 20 µm.
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PMC9429973
Safety profiles were generally similar across both cohorts.
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PMC11224206
Together, these two processes comprise approximately two-thirds of the energy budget of somatic cells.
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PMC10975211
Their findings indicated that the administration of buforin IIb could effectively inhibit the progression of cancer xenografts in vivo (>5 mg/kg), suggesting that buforin IIb holds promise as a new therapeutic intervention for the management of cancer .
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PMC11489275
However dynamic changes in lymphocytes can better reflect the disease status and better predict the short-term prognosis than baseline lymphocytes in MDA5 + DM-ILD patients.
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PMC10965680
To determine nucleotide diversity in each goat breed, we employed a sliding window method and VCFtools v4.1 software (Zhang et al., 2019).
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PMC11409031
Through UMAP analysis, a total of 15 cell clusters were identified in all samples. (
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PMC9895440
We performed a co-culture of peptide-loaded T2 cells with T cells in the presence of CD107a antibodies to assess the degranulation of cytokine production of T cells.
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PMC11746948
Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article.
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PMC7812570
Transduced target cells displayed resistance to divergent cell-free HIV-1 infections, viral Env-mediated cell-cell membrane fusion and cell-associated virion-mediated cell-cell viral transmission.
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PMC9429973
PreTx TB was lower in SOC patients with ongoing response vs nonresponders and patients who Summary/Conclusion: Axi-cel was superior to SOC in all subgroup analyses, including higher TB and LDH.
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PMC8633974
These data suggest that the locus targeted by TatE gRNA is critical for maximal CRISPR activity.
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PMC9672323
The effect of drugs on the cell cycle phase of A-172 cell line.
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PMC11777207
Thus far, we have only tested DC egress from the skin in the context of a local inflammatory stimulus including polyI:C injection, IMQ treatment, and a melanoma model.
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PMC5854676
After experimentation, the cells were incubated with CMH2DCFDA for ROS detection (Fig. 11 (micrograph) and Fig. 12 (ROS snapshot)).
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PMC5941560
Additionally, insertion calls with breakpoint distances greater than the insertion size were filtered out of the final call set.
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PMC7294030
The percentage of apoptotic cells which are condensed chromatin or fragmented chromatin was calculated from 500 counted cells (Hahnvajanawong C et al., 2004).
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PMC11459296
This model opens new avenues for assessing novel immunotherapies.
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PMC11092418
Tumor cells that were examined when grown in control wells (i.e., only medium) were confluent.
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PMC11045125
The pcDNA3 vector is from Invitrogen, (Waltham, MA).
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PMC11472569
The ability of ABCG2 to expel a wide range of drugs from cancer cells enables these cells to evade the cytotoxic effects of chemotherapy.
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PMC11348300
The fitting procedure was applied to both the healthy tissue’s and tumor tissue’s HS-value time profiles.
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PMC11721295
Percentage colocalization – αSMA/PDGFR, MPO/F4/80, p-EGFR/ECAD – was quantified as area from stain 1 that overlapped with area from stain 2.
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PMC6684588
A small incision was made to reveal the distal tendons of the ankle dorsiflexors.
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PMC9429973
Because patients from ZUMA-5 did not use bridging chemotherapy, the primary analysis compared a patient subgroup not exposed to bridging chemotherapy in ELARA (N=53 [infused set]; N=50 [efficacy-evaluable set]) with patients in ZUMA-5.
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PMC10944868
Under these conditions DMSO was also used in the controls and was not seen to affect tested compounds activity.
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PMC11012313
However, in some of these experiments, HIF-1α was overexpressed and the normal regulation of HIF-1α was lost, which may impact the interpretation of these data.
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PMC11342785
All TPPP variant and TPPP-chimeras constructs were expressed in BL21(DE3).
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PMC8389560
It was found that in glioblastoma cells and malignant mesothelioma cells expressing Cx43, a reduced level of expression of antiapoptotic Bcl-2 and Src was observed which promoted carcinogenesis .
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PMC6450504
The cells were then detached using enzyme-free cell dissociation buffer and processed using the same protocol described earlier for P-gp staining.
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PMC9429973
Preclinical characterization of AFM28 pharmacology and toxicology in vitro and in vivo to support clinical development.
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PMC11317131
Activated gIII expression leads to propagation of the SP that encoded the improved integrase.
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PMC9429973
The bias and limits of agreement between the automated and manual measurements of LIC were assessed.
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PMC11672617
The impact of ionic compounds on the cell cycle is typically distributed across all phases, although certain phases are more susceptible to influence than others.
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PMC9429973
Using HSPCs from patients with sickle cell disease as a therapeutically relevant model, we investigated if this DNA donor can replace the non-functional HBB gene that produces HbS. Gene replacement of the sickle allele using the optimized DNA donor restored physiologic HbA expression (by HPLC) comparable to an HDR gene correction strategy that corrects the HbS point mutation.
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PMC11033180
G and G′) Double immunolabeling for Plexin A2 (green) and Hu (red) in the myenteric plexus of rat distal colon.
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PMC8839885
This supports the species selectivity of the primers used.
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PMC6627640
TGCTs have an intrinsic hypersensitivity to cisplatin-induced cell death .
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PMC11095939
Total protein (1 mg) was incubated with anti-Mecp2 (5 μg) overnight at 4°C with constant mixing.
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PMC11310713
These microspheres offer versatility in administration, including transplantation, direct tissue injection, and intravenous delivery [20–22].
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PMC11742670
Most of the above common features are related to specific physicochemical properties such as molecular weight, molecular polarizability, and topological structure.
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PMC9780037
Cyt c could also be recovered from this ionic liquid without compromising its properties .
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