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PMC9429973
A greater percentage of patients on pacritinib reported “much” or “very much” improved symptoms (35% vs 16%, p=0.06; Figure 1A).
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PMC8711270
Although the production of rAAVs for the above therapeutics were performed in adherent-based systems, suspension-based rAAV production technologies have been also developed recently.
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PMC11332076
It will also be intriguing to explore potential synergistic effects of F-iIR or F-iIGF1R combined with F-iTrkB on glaucoma symptoms.
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PMC11787651
Glycan structure and localization, a classically challenging study, has also benefited from electron-based fragmentation by improving the detection and quantitation of multiple isomeric glycoforms in a single analysis (47, 48, 49, 50).
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PMC11307990
The 786-0 cells were donated by the first affiliated hospital of Ningbo University.
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PMC5810978
This treatment protocol was routinely used for the preparation of stool suspension for enterovirus isolation in cultured cells at the Department of Virology II, National Institute of Infectious Diseases.
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PMC10507284
The process of drug reutilization can provide new insights into the pathogenesis of disease and find new opportunities for drug intervention.
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PMC9164404
In vitro, the IC50 of Abplatin was 1.35 µM on A2780 cells, much lower than that of cisplatin at 25.10 µM. Abplatin exhibit excellent killing capability even on the cisplatin-resistant cells such as A2780DDP and BEL-7404DDP cells.
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PMC11723947
To analyze Tconv and Treg from transplanted mice, CD4 T cells were first enriched by positive selection using mouse CD4 (L3T4) microbeads (Miltenyi Biotec) and then stained with APC-Cy7-conjugated anti-CD45.1, BV421-coupled anti-CD45.2, FITC-conjugated anti-H-2K, PE-labeled anti-H-2K, APC-coupled anti-Thy1.1, V500-conjugated anti-CD4 and BB700-labeled anti-TCR Vβ6 antibodies.
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PMC10667689
The mRNA expression of ACC-1 was increased in a time-dependent manner in the presence of Gal-9 compared to PMA and the control group in both cell lines (A, B).
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PMC9429973
Summary/Conclusion: Using a targeted NGS gene profiling analysis, we demonstrate a significant difference in expression levels of multiple immune-response genes in RT vs CLL.
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PMC7582629
However, Raman imaging experiments require the acquisition of many thousands of spectra and, typically, total acquisition times for these, depending on the desired spectral quality, would be in the order of a few minutes to several hours.
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PMC5810978
Furthermore, a monkey kidney cell line, Vero, was also included because of their versatile capacity to propagate a variety of viruses.
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PMC11323699
Unfortunately, many of these patients fail to respond, or they relapse during PARPi treatment, and demonstrate poor outcomes with subsequent chemotherapy, probably due to overlapping resistance mechanisms .
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PMC9429973
Activation of the Wnt/β-catenin pathway is required for the survival and development of LSCs and therefore, targeting β-catenin is a potential therapeutic strategy.
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PMC9599726
We observed that VP increased the mean difference in green intensity fluorescence (FITC-channel) in GIST882 and GIST48 cells (Figure 5A) in a dose-dependent manner, corresponding to an increase in lipid peroxidation.
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PMC9164404
The tumor inhibition curve indicated that Abplatin had the most obvious tumor inhibition effect, followed by cisplatin (Fig. 3D).
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PMC6312945
The proliferation of BEL-7404 cells in the BEL-7404 pSUPER.neo-miR-101 group was significantly lower than that in the BEL-7404 pSUPER.neo group (P<0.05).
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PMC11218145
Fig. 5FOH and GGOH-mediate restoration of TB cytotoxicity in MPM cells.
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PMC11684821
Next, we tested CD8 T cells from Donor 216T expressing the MC.7.G5 TCR against a wider panel of MR1*01 or MR1*01/*02 cancer cells (Figure 2F and Supplemental Figure 5, E and F).
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PMC11064533
.
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PMC10850553
We then confirmed the co-localization of tPA and Plasminogen in same cells in lesions (Fig. 6A, Supplementary Fig. S1).
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PMC11666785
An estimated 49,020 images are recorded for reconstructing standard SMLM image as shown in Fig. 2.
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PMC11240052
We further demonstrated that miR-211-5p mimics down regulated SIRT-1 mRNA and protein expression while miR-211-5p inhibitor upregulated SIRT-1 mRNA and protein expression in ovarian cancer cells.
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PMC10203589
Therefore, for effective prevention of colorectal cancer progression, selective inhibition of FGFR3-IIIc, WNT or MAPK and PI3K/AKT signaling pathways in CRC cells, as well as selective targeted therapy of CD44-positive subsets of CRC cells can be used.
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PMC11536589
Difference analysis between KPC cells in Cluster 2 and Cluster 5.
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PMC11489351
C, representative confocal images of MCF10A cells treated as in (A).
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PMC11594588
This phenomenon has been defined as myocardial infarction without significant coronary artery obstruction and has been the subject of extensive cardiovascular research.
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PMC2614416
All calculations are carried out on "Medusa," a high performance dual tower, 64-node Beowulf cluster having 32 Gigabytes of SDRAM and 1 Terabyte of storage.
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PMC11707577
The nanoarchitectonics approach employed for M13 functionalization and targeting may have a more broadly application: i) M13 phage may be genetically reprogrammed to target different cell types, from cancer cells to bacterial cells, and thus exploited for anticancer as well for antimicrobial strategies; ii) the morphology of the desired TNP may be finely controlled by selecting the viral template, and this in turn may drive the synthesis of TNP with well‐defined shapes and desired size; iii) the chemo‐physical properties of the TNP may be easily tuned by molecular engineering of the oligothiophene unit used to synthesize the TNP; iv) different semiconducting nanoparticles with tailored properties, can be synthesized, replacing the oligothiophene derivatives with diverse molecular scaffolds, opening up new scenarios for light controlled therapies/imaging procedures.
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PMC11786600
Process demonstration images of portable electrospinning. (
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PMC11122631
The significant difference between them was the pattern of H-11 (doublet in 2 and singlet in 3), and an additional proton (H-10) was found in 2.
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PMC11188874
The rank-order effect of hits on proteasome ChT-like activity in RPMI-8226 cells is shown (Fig. 1B).
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PMC11766174
Overall, CA-ICC offers a simple imaging method for specific and sensitive detection of CA-positive cells in bulk cell preparations.
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PMC8916024
In order to avoid the influence of individual differences in snails, this study took the same amount of DNA samples from 10 individuals in the parallel group and pooled them as sequencing samples.
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PMC11064533
The data comprise median values and median absolute deviation of five separate experiments in triplicate (A and B) or ratio of median values for antibiotic-treated and untreated bacteria (C and D).
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PMC11672617
Furthermore, in methods involving the fractionation and isolation of mitochondrial proteins, which often employ harsh mechanical means such as homogenization, incomplete or excessive mitochondrial disruption may occur, which may result in an over- or underestimation of the amount of cytochrome c in the cytoplasm.
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PMC9429973
Ultimately these characterizations will help to advance the understanding of molecular mechanisms and susceptible populations associated with B-ALL.
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PMC10079526
His10-SUMO2 target proteins were enriched from Namalwa and U2OS treated with 5-Aza-2’ or DMSO for 4 h or 20 h (Fig. 2A) .
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PMC10747139
Recent studies have been focused towards the synthesis of new analogues of RAED-C and RAPTA-C, which are two Ru(II) complexes that have shown excellent antitumoral activities in both in vitro and in vivo studies.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", "been", "focused", "towards", "the", "synthesis", "of", "new", "analogues", "of", "RAED-C", "and", "RAPTA-C", ",", "which", "are", "two", "Ru(II", ")", "complexes", "that", "have", "shown", "excellent", "antitumoral", "activities", "in", "both", "in", "vitro", "and", "in", "vivo", "studies", "." ] } ]
PMC11683240
The B pentamer allows the binding of PT to sialoglycoproteins on target cell surfaces, facilitating entry through receptor-mediated endocytosis (15, 16).
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PMC10809689
According to the kit protocol, 50,000 cells/well from each group (control, P24, PG72) were seeded duplicated in 96 well plates.
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PMC11352746
The automation and innovation of these systems offer researchers an efficient approach to studying biological systems in real-time.
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PMC11011837
Moreover, metabolites such as acetylcholine vary in different ways in these cell lines; in fact, Molt-4 demonstrates a high abundance of it; on the other hand, Molt-16 and CCRF-CEM demonstrate similar abundance, while Jurkat demonstrates a low abundance of this metabolite.
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PMC9429973
Our centre introduced universal midazolam sedation unless there is a contraindication to its use, 4 years ago.
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PMC9429973
Secondary endpoints include complete response rate, overall survival, safety, and quality of life.
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PMC11774747
Only one team has described results of CAR-VST produced thought a lentiviral transduction, with increased CAR expression from 8% to 46% after 2 rounds of stimulation (N=3) in a first study and 27.0 ± 14.2% CAR (N=9) in their second study (92, 93).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", "one", "team", "has", "described", "results", "of", "CAR-VST", "produced", "thought", "a", "lentiviral", "transduction", ",", "with", "increased", "CAR", "expression", "from", "8", "%", "to", "46", "%", "after", "2", "rounds", "of", "stimulation", "(", "N=3", ")", "in", "a", "first", "study", "and", "27.0", "±", "14.2", "%", "CAR", "(", "N=9", ")", "in", "their", "second", "study", "(", "92", ",", "93", ")", "." ] } ]
PMC7189327
These findings provided indirect evidence for the hypothesis that CYFIP2 participated in the pathogenic mechanism of BCC.
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PMC9429973
CTPS1, which catalyses the rate limiting step in pyrimidine synthesis, plays an essential and non-redundant role in B and T cell proliferation but is complemented by the homologous CTPS2 isoform outside of the haemopoietic system .
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PMC10713411
Knockdown of TRIB3 decreased the proliferation potential, invasion capacity and colony formation ability of A498 cells.
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PMC11244823
The desired amino acid sequences were reverse-translated and codon-optimized for expression in COS cells.
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PMC9429973
Before application in clinical trials, novel therapies require preclinical testing which is resource intensive.
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PMC9429973
Eligible pts must have had spleen volume and/or TSS data at BL and EOC6.
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PMC10748106
More than 30 scientific works of literature were consulted from 2004 to the date, gathering forty-four iridoids with reported cytotoxic activity in a cervical cancer cell line.
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PMC11279397
A bioactivity score >0 indicated promising activity; a score between −0.50 and 0.00 represented moderate activity; while a score ≤ −0.50 indicated no activity .
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PMC9429973
Treatment included chemotherapy(containing nitrogen mustard phenylbutyrate, fludarabine, cyclophosphamide), proteasome inhibitor regimens, rituximab regimens and immunomodulator regimens.
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PMC9429973
After analysis, we reviewed the different results and correlated them with clinical information’s and vice versa.
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PMC11321678
Furthermore, GRM8, the characteristic NTR of Group 4, showed significant elevation in EOMES overexpression cell lines but not in Group 3 MB cells (Figure S8E,J, Supporting Information).
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PMC9429973
All but 1 patient engrafted, with a median time to neutrophil and platelet engraftment of 11 (range 8-16) and 19 (range 9-40) days, respectively.
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PMC11122631
We now report the isolation and structure elucidation of two new and eleven known prostanoids (1–13) from the same specimen (Figure 1).
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PMC11703896
viability = ALK, EGFR, FGFR, MET, and ROS1 receptors were selected based on their known roles in cancer progression and therapeutic relevance, particularly in lung cancer.
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PMC11574029
A, B The expression levels of four Notch pathway ligands in tumor and normal tissues in the GSE13507 and GSE37815 datasets; C, D The expression of NOTCH3 in tumor and normal tissues in the TCGA-BLCA cohort; E, F Comparison of overall survival and disease-specific survival between high and low NOTCH3 expression in the TCGA-BLCA cohort; G, H Protein and mRNA expression levels of NOTCH3 in BLCA tissues and adjacent normal tissues; I Representative images and quantification of NOTCH3 protein immunohistochemical staining in BLCA tissues (n = 40) and normal tissues (n = 40), scale bar: 50 μm; J Western blot analysis of NOTCH3 protein levels in SV-HUC1, T24, and 5637 cells.
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PMC11626627
Wound-healing assays (C-D) and transwell assays (E-F) were performed in 786-O cells transfected with pLKO.1+pLVTHM, oe-circATP2B1+pLKO.1, oe-TWIST1+pLVTHM, and oe-circATP2B1+oe-TWIST1 to validate the effects of circATP2B1 and TWIST1.
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PMC11194678
Luminescence was detected using a Synergy 2 Multi-Mode Microplate Reader (Biotech) at 25°C.
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PMC11703896
A moderate cytotoxicity response was observed in the osteoblast cell line MG63 with an LC50 value of 48.84 ± 10.
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PMC11730305
Statistical differences were evaluated by one-way analysis of variance (ANOVA) using SPSS software (version 22) and a p-value of less than 0.05 was considered statistically significant.
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PMC11252553
Many factors can intensify or attenuate the Ionizing Radiation (IR) effects on cell damage .
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PMC9429973
The addition of daratumumab (Dara) to frontline therapy also improved response rate and progression free-survival in TE-NDMM patients (CASSIOPEIA, GRIFFIN).
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PMC10170482
All cell lines were authenticated by short tandem repeat (STR) DNA profiling (ATCC, Manassas, VA, USA).
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PMC11334037
This study investigated IGF2 regulation of metastasis and imatinib resistance in GISTs.
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PMC11413393
Encouragingly, our preclinical in vivo models also demonstrate significant tumor growth inhibition following MS023 administration and PRMT1 genetic depletion, suggesting this enzyme represents a viable therapeutic target for potential clinical development.
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PMC9429973
Blood (2019) 134 (Supplement_1):1375.).
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PMC11490153
The stretching vibration at 2918 and 2862 cm is attributed to C-H stretching vibration.
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PMC11623887
Our results showed a significant increase in fold change expression of (NS1 ∽12.3, VP1 ∽27.6, VP1-2 ∽3, 11kb protein ∽38) in GATA1 transfected cells compared to the control group (P<0.05).
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PMC9884169
Therefore, the expression of ferroptosis protein markers, including FSP1and SLC7A11 after the knockdown of MCT4in 5637cell lines was determined to verify the relationship between MCT4 and ferroptosis.
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PMC11693599
The protein level of CD109 was markedly increased in A2780-SP and SKOV3-SP cells compared with two-dimensional (2D)-cultured A2780-AD and SKOV3-AD cells (Fig. 1B).
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PMC11089031
Comparisons of gene expression levels and IHC staining between tumor and adjacent normal tissues were performed using a paired t-test, otherwise unpaired t-tests were used.
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PMC6642070
C2C12 myoblasts were stimulated to differentiate into myotubes by switching to the medium with 2% horse serum.
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PMC11411131
The full-length TrxR1-GFP did not show a fluorescence signal, whereas the truncated version did.
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PMC6160470
In comparison to compounds alone, co-treatment of cells with PTX and verapamil or crown ethers significantly increased the number of apoptotic cells (Annexin V positive cells; Fig 3e and S12).
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PMC9429973
Alternatively, SF3B1 clonal hematopoiesis of indeterminate potential (CHIP) may represent a relevant pre-phase of SF3B1 AML.
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PMC11785489
Thus, we compared TCR-mem scores between SP and DP prenatal T cells (14,584 cells, dataset 6, Table 1; STAR Methods).
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PMC11772585
β-Tubulin was used for the normalization control.
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PMC9429973
Immunohistochemical staining of bone marrow trephines and bone plasmacytomas biopsy specimens made with using a stainer Leica Bond-Max, reactions with antibodies to CCND1 (clone SPA4, Cell Marque), NSD2 (clone 29D1, Abcam), c-MAF (clone ERP16484, Abcam).
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PMC11322866
Cells were then examined by immunofluorescence staining with anti-Lamin B1 antibody (red) and DAPI staining (blue).
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PMC11412721
Each point is the mean from four independent MEF clones, the value for each clone resulting from triplicates. (
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PMC11541241
The connection between the TOR signalling pathway and the STRIPAK complex in this study also provides a framework for future research about the function of the TOR pathway in the cell wall integrity pathway.
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PMC8143558
Therefore, its absence as enhanced by its interaction with saponins may hinder the success of attack of human cells by microorganisms .
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PMC8009078
Another pyrin ring contains carbon-hydrogen groups that interacted with Gln377 with a distance of 2.94 Å. In addition, the methyl group of pyrin ring was found to form one HB with Leu378 with a distance of 3.09 Å. The 5-hydroxyl functional group present in flavone was found to one HB with Lys449 with an interatomic distance of 2.05 Å. Furthermore, compound A3 interacted with the TMPRSS2 as shown by the calculated Prime-MMGBSA BE (− 50.510 kcal/mol), which was less than compound A1 and A2 but higher than compound A4 along with ADV binding energy (− 8.90 kcal/mol) and the Glide dock score (− 7.888 kcal/mol).
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PMC10818573
RPA reagents are commercially available, and the basic RPA reaction kit can be augmented by additional commercially available kits that use different probes: exo, fpg, and nfo .
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PMC8728081
The distribution of Rasasindura particles was not homogeneous among cells, as Rasasindura comprises a wide distribution of particle sizes.
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PMC10530622
Although the stomach is involved in the absorption of oxalate, the small and large intestine appear to be most important .
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PMC8041314
Three initial selection criteria were formulated: (i) the compound must have contained at least one of the six identified basic scaffolds (Screen 1: “Scaffold Search”; Figure 2); (ii) the compound must have contained at least one of the defined clear positive hits (Screen 2: “Positive Pattern”); and (iii) the compounds must not have been equipped with any of the clear negative hits (Screen 3: “Negative Pattern”).
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PMC11541409
Wolska-Washer, A. and T. Robak, Acalabrutinib: a bruton tyrosine kinase inhibitor for the treatment of chronic lymphocytic leukemia.
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PMC11453346
Furthermore, increased H6PD activity was observed when this protein was co-expressed with AGR2 in HEK-293 cells.
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PMC9341513
It leads to significant changes in expression which are similar to those resulting from a reciprocal translocation.
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PMC11765678
Notably, both Erastin and RSL3 significantly enhance the cytotoxic effects of Adriamycin and Topotecan in Pgp- and BCRP-expressing cells, with RSL3 proving more effective by also sensitizing drug-sensitive cells.
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PMC11597291
The hemolysis caused by nCGO-PEG was very low, lower than 5%, even at the high concentration of 1 mg/mL. The pristine nCGO particles caused higher hemolysis than the nCGO-PEG particles, reaching a hemolysis value of around 15% at the concentration of 1 mg/mL .
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PMC9841531
After adding a trace quantity of crushed ice, the mixture was basified with 5 M sodium hydroxide (pH = 14).
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PMC6684588
This was followed by a 2-hour incubation with HRP-goat-anti-human IgG-Fc (1:5000; Jackson Immunoresearch, West Grove, PA).
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