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PMC11224020
Hence, DCs use the cytoskeleton–lipid metabolism interplay to respond to environmental physical constraints that imprint them with specific immunoregulatory properties.
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PMC6114978
Normal smooth muscle was utilized as a positive control (Supplementary Figure 1B).
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PMC11627133
Peptide‐PAINT, another variation of DNA‐PAINT utilizing transient peptide‐peptide interactions, has also been applied for super‐resolved protein imaging.[ , ]
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PMC11413393
For example, BAP1 driven ccRCCs are known to have inherently compromised BRCA-mediated DDR pathways and may exhibit enhanced sensitivity to further DDR perturbations, while SETD2 driver mutations already display splicing defects and may have enhanced responses.
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PMC9429973
Limit of detection and quantification, linearity, intra-/inter-assay precision, and robustness were determined via spike-in assays.
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PMC9429973
Image: Summary/Conclusion: Facilitating treatment of patients affected by the novel coronavirus represented a welcome change in healthcare system in early 2020, in our country and abroad.
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PMC10454535
RPMI-1640 medium for U266 cells was supplemented with 15% FBS and 1% penicillin-streptomycin.
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PMC10748106
In the case of Genipin, these zones of higher electron density also correspond to the sp2 and sp3 oxygens, the oxygen of the hydroxyl at C1, and the oxygen of the hydroxyl at C10, correlating with our earlier observations regarding molecular electrostatic distributions.
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PMC9429973
However, its mode of action is not clearly established.
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PMC7612475
As such, these data provide the first evidence that tumors with spliceosome mutations can be specifically targeted with clinically relevant therapies currently in use.
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PMC11629143
Schematic depicting pooled sgRNAs targeting the dCas9‐p300 fusion to the CMV promoter driving mAb light and heavy chain genes in CHO‐K1 cells. (
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PMC10158546
Representative images are shown at days 7 and 21 post-differentiation.
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PMC11628904
The stable conversion of native green Dendra2 fluorescence to red fluorescence was carried out using a 405‐nm laser set to 10‐μs/pixel dwell time and 45‐s total stimulation time.
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PMC11298021
GEO2R analysis of GSE225751 showed that the main genes of mTOR signaling pathway were downregulated after Everolimus treatment.
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PMC11476222
In CRL-1620, eight sphingolipids were identified and quantified, and Ceramide (Cer) and Ceramide phosphates (CerP) were the most abundant, as shown in Figure 6B, with a percentage relative abundance of 50.0 ± 0.5 and 49.3 ± 0.8, respectively.
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PMC11055323
Two-sided Wilcoxon test adjusted for multiple comparisons.
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PMC11576293
The data indicate that the 4-position substitution markedly influences the antiproliferative activity of these compounds, with the most pronounced activity observed in compounds containing 4-Cl phenyl or 4-OMe phenyl groups.
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PMC11279397
The antiviral activity of main terpenoids in Perilla frutescens, with an OB value exceeding 20%, is presented in Table 4.
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PMC9429973
With ACG-F, frailty was noted in 11% in MPN cases and was associated with increased mortality after adjusting for comorbidities and advanced age in all MFN subtypes [HRs in ET 2.5 (2.2-2.8), PV: 2.1 (1.8-2.4), and MF: 1.8 (1.5-2.2)].
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PMC11786767
COS-7 cells were treated with RO-3306 and then stained with biotin-DHPE, Ki-67, and DAPI.
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PMC11768927
Furthermore, the inclusion of the IFN-β gene enhanced oncolytic efficiency by improving the virus’s ability to target and kill cancer cells, while also stimulating an antitumor immune response.
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PMC11467800
Cells were cultured in RPMI 1640 supplemented with 10% fetal bovine serum (FBS), 1 unit/mL penicillin G and 1 mg/mL streptomycin at 37°C and 5% CO2.
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PMC11697703
After purification (Qiagen MinElute PCR purification Kit) the DNA fragments could be stored at -20C.
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PMC9429973
The mean age was 24.17 (SD 13, Median was 24) years and 53% of the patients were female.
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PMC9429973
Aims: Assess the genetic predisposition of recipients to the development of HLA alloimmunization.
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PMC11740508
M231, M231 cells with intact HRR genes; M231, cells with targeted mutations in BRCA1; M231, cells with targeted mutations in BRCA2 mean ± SEM calculated and significance determined by two-way ANOVA with Tukey’s adjustment for multiple testing.
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PMC11476004
According to Sapierzyński and Dernell et al. , there is a correlation between cancer and the size of dogs.
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PMC9429973
Compared to toxicity of sub-sequent pharmacotherapy or allogeneic transplant, tandem ASCT is well-tolerated.
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PMC8270637
n = 3, *P < 0.05, **P < 0.01 vs. control group.
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PMC11588085
UMAP of XIST (Left) and CD44 (Right) on ovarian cancer patient single-cell sequencing data.
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PMC11394227
In this study, we observed that the proportion of fully folded antibodies (HC-LC)2 in CHO-PAb-QS cells was approximately twice that of CHO-PAb cells.
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PMC8956657
Assays were repeated in triplicate and contained a negative control (no binding partner) and blank (Tris buffered saline, pH 8).
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PMC9878278
Similarly, a recent in vivo study (Qin et al., 2019) reported that exposure to poly I:C induced IFN and inflammatory response via TLR3 and impaired blood-testis barrier in mouse testes.
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PMC9444294
There was also a single instance of a novel fusion event between SS18 exon 9 and SSX1 exon 7 (Fig. 3D&H).
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PMC10759659
Finally, the slides were stained with DAB and haematoxylin.
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PMC11697703
Fluorescence intensity in the white matter is constant across samples and was used for normalization.
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PMC10728200
As pictorially modeled in Fig. 8, this study for the first time demonstrates that IM induces ferroptosis in GIST by promoting STUB1-mediated GPX4 ubiquitination, offering a novel mechanism for the inhibition of GIST.
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PMC10317042
In addition, the cleaved caspase-3 protein was detected in the four CCS cell lines following vorinostat treatment (Fig. 1C).
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PMC11763126
Compared to adjacent normal tissues, 118 peptides were differentially expressed in ccRCC, with 52 peptides upregulated and 66 peptides downregulated (Fig. 1A, B).
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PMC11672881
While these findings strongly support the potential of CU and TQ as a combined therapeutic strategy, further studies are needed to elucidate the precise mechanism of action and molecular pathway involved and to validate these results in preclinical and clinical models.
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PMC9429973
Further evaluation of nemtabrutinib in B-cell malignancies is ongoing.
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PMC11743316
In addition, p-CFL1 expression is substantially higher in chemoresistant patients compared to chemosensitive individuals.
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PMC11371627
Clinical findings associated with XK variants comprise a multisystemic spectrum disorder including acanthocytosis, haemolysis, anaemia, spleno- and hepatomegaly, cardiomyopathy, myopathy, neuropathy, dystonia, choreatic movement disorders as well as neuropsychiatric disorders and cognitive decline.
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PMC11701801
−CP-C27 (n = 8 biologically independent mice per group); +CP-C27 (n = 8 biologically independent mice per group).
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PMC11144382
Western blot analysis also showed significantly increased CRABP2 expression in Nfix MEFs (6-fold, P <0 .0001, Figure 3A and C).
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PMC11657744
Two-way ANOVA followed by Dunnett’s multiple comparisons test was conducted. *,
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PMC11740508
In contrast, the parental MDA-MB-231 cells and other HRR proficient cell lines produced smaller cell populations with short term treatment, but with much less cumulative DNA damage, and minimal cell death.
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PMC11473843
Graphical data are mean ± SD.
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PMC9221284
A mice were kindly provided by Dr. David SKAAR (Department of Biological Sciences, Centre for Human Health and the Environment, North Carolina State, University, Raleigh, NC, USA) for epigenetic studies.
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PMC11704834
To date, the molecular mechanisms underlying EGFR-TKI-induced apoptosis have not been fully elucidated.
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PMC7185206
Supernatants were initially centrifuged to remove non-adherent cells.
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PMC11770746
The test was carried out on a mesh floor, and acetone was dabbed on the plantar surface of the hind paw.
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PMC10568263
Effective diagnosis and therapeutic strategies are critical to cancer progress management and mortality reduction.
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PMC11401358
The irreversible oxidative damage of biological macromolecules, such as oxidized proteins, lipids, and nucleic acids, triggers a variety of cell dysfunctions and then induces diseases .
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PMC11407042
Note: See problem 2 for the cell cluster solution.
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PMC11406030
The unfavorable prognosis associated with patients exhibiting higher cytoplasmic than nuclear LMTK3 remained significant in the multivariable analysis.
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PMC11665555
Finally, TFs with both Fisher’s exact test P < 0.05 and random permutation P < 0.05 were selected as key TFs for the regulation of the transcriptional changes.
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PMC11394730
These studies showed the potential of allicin to inhibit tumor growth in vivo.
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PMC10808409
Our results demonstrated that both ferulic acid and TPGS mixed micelles formula inhibit the growth of the different cancerous cells and decrease cell viability (Tables S2–S7) with the TPGS mixed micelles formula being more effective in cell proliferation inhibition especially on Caco-2 human colorectal cancer cell line (Table S3).
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PMC8073654
In our follow-up study on the P-gp inhibitory effect of the constituent of Z. cassumunar , trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene (11) exhibited potent P-gp inhibitory activity when the IC50 value of DNM was decreased by more than that of verapamil.
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PMC11739484
GEPIA2 was chosen for this analysis because it provides a robust and user-friendly platform that allows for direct comparisons of gene expression between normal and tumor tissues using TCGA data, offering high-resolution and large-scale cancer-related gene expression data.
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PMC10669966
Genome annotation file and version used in the QC calculations was Homo_sapiens.
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PMC11139449
PEI transfection successfully delivered the constructs to nearly 65% of the clones, with the majority being homozygous.
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PMC10040136
Although surgical resection has been the cornerstone of GIST therapy, the recurrence of GISTs after surgery is a common occurrence within a short period of time.
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PMC11638255
a Experimental design and dosing strategy of Th-MYCN model with peripheral blood and tumors obtained after 1 week of treatment.
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PMC9429973
Numerous studies provide evidence that inflammation increases the risk of several cancers.
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PMC9429973
Aims: We aim to describe the mutational landscape and outcome with upfront targeted tyrosine kinase inhibitor (TKI) therapy in patients (pts) with MLN-Eo.
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PMC10006224
The two complexes also display different chromatin association dynamics that determine their contributions to loop formation and stability.
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PMC11666785
The corresponding mean localization precision for all χ-values are also plotted in Fig. 3B.
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PMC11352666
EWS-FLI1 also induces BCL-2 expression .
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PMC9429973
Non-germinal center B-cell (GCB) cell-of-origin subtypes is a poor prognostic factor for EFS in SOC (EFS was significantly worse in SOC patients with non-GCB vs GCB; HR, 1.82 [95% CI, 1.12-2.96]; P=.02) but not in axi-cel.
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PMC9966931
Three phytopathogenic fungi: Fusarium oxysporum f. sp. lactucae J.C. Hubb.
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PMC11544771
Also, a lower band, which migrates rapidly and represents the dephosphorylated protein, was observed after 20 μM of CPX treatment and the combined treatment in A549 cells (Figure 4C) as well as the combined treatment in A427 cells (Figure S2C), indicating that the high concentration of CPX or the combined treatment inhibited the phosphorylation of Rb.
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PMC10577955
Significance from A549 cells (untreated) at P < 0.0001, # Significance from BA treatment at P < 0.001, $ Significance from LUP treatment at P < 0.001 Cell cycle analysis of A549 (untreated) and treated with IC50 ALUP, BA, LUP for 48 h ALUP, BA, LUP (0.805 µM, 0.836 µM, 0.808 µM respectively): A Histogram showing the percentage of cell population in each phase of cell cycle analysis.
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PMC6892818
Results are presented as % DNA fragmentation relative to positive control (maximal DNA fragmentation) and are representative of two experiments.
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PMC11594074
These compounds were selected from two subsets of the ZINC15 database and the FDA-approved subset, and the three-dimensional structures were downloaded from https://zinc15.docking.org, accessed on 7 November 2022.
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PMC9727330
Cell viability rate of Caco-2 cells that were pretreated with indicated concentrations of either Asp or NNDAsp for 24 hrs compared with DMSO (0 concentration). (
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PMC9429973
Aims: As it was reported that the activity of human microbiome is involved in cancer development and host response against anticancer therapy, the aim of this study was to investigate the stool and oral microbiome alterations in CLL patients with respect to selected prognostic and predictive markers.
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PMC11594641
As previously reported, this cell line is characterized by elevated expression of other Rab GTPases involved in sEV biogenesis and loading, i.e., Rab7 .
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PMC11411004
Despite cell cycle arrest at the G1/G0 phase, which inhibits cell growth, the addition of the inhibitor at 2 µM to monoclonal antibody-expressing CHO cell cultures resulted in a 1.94-fold increase in the maximal monoclonal antibody titer and a 2.43-fold increase in specific monoclonal antibody production.
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PMC9429973
Summary/Conclusion: ZO demonstrated superior efficacy to O in treatment of pts with R/R FL.
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PMC2777936
Colony formation ability of FZD7 shRNA infected cells versus controls is displayed.
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PMC11401350
Mice were sacrificed at humane endpoint or 200 days post-transplant (****p < 0.0001, Mantel-Cox test).
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PMC11779876
We discarded cells with missing TRBC expression if the fraction of those cells was less than one third of all cells sharing the same clonotypic CDR3 sequence.
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PMC11802929
CD8 T cells were captured by SCT-dextramers from 62 HLA-matched COVID-19 participants for scRNAseq and TCR sequencing.
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PMC6268318
The compounds responsible for these activities in this plant were not sought (Table 1).
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PMC11476004
They can be used following the treatment process to reveal the effectiveness of the body’s fight against carcinogenic factors, which we can easily observe using lymphocytes.
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PMC11687167
Patients with ASCVD and high LDL-C on statin treatmentInjection-site reactions, nasopharyngitis, and upper respiratory infectionsAlirocumab 1.
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PMC11530949
However, these NPs have practical limitations, including instability, premature drug release, rapid clearance, and susceptibility to immune responses (15, 16).
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PMC10818573
When cellular DNA was used as the assay sample, both the B95-8 and Raji samples showed obvious target bands, while HeLa samples showed no target bands, consistent with the expected results (see Figure 1B).
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PMC11371747
SEM was within the size of the marker).
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PMC11754094
Another 24 h later, cell selection was initiated with 2 µg ml puromycin and continued for 2–3 days.
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PMC11291490
Then, the fragment was integrated into the pVAX1 vector from Invitrogen, which includes the signal sequence of tissue plasminogen activator (TPA) (MDAMKRGLCCVLLLCGAVFVS), resulting in the construction of the dusCD40L eukaryotic expression plasmid designated as pVAX-TPA-dusCD40L.
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PMC3675084
Selected reaction monitoring (SRM) of the precursor-product ion transitions m/z 342 → 195 for BPR0L075, and 212→ 144 for IS were used for quantification.
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PMC10890055
The weight of the input powder mixture was 30 g. The mill equipped with a water-cooling system enabled us to keep the temperature of the process low.
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PMC11344246
This value was then doubled to identify the intensity value at the peak of the G2/M phase.
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PMC11334037
The apoptosis rate was determined by analysis of Q2 and Q3 quadrant cells.
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PMC11549062
The secondary antibodies (1:10,000) were incubated with the membranes for 1 h at room temperature.
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PMC11543885
Fixed Modification: Set Carbamidomethyl (C) as the fixed modification.ii.
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PMC11463018
C NMR (101 MHz, DMSO-d6) δ: 166.03, 150.65, 144.03, 136.42, 132.94, 132.28, 131.65, 131.28, 131.12, 129.52, 128.76, 127.39, 127.10, 126.78, 112.80, 112.27, 45.57.
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