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OTAR3088
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BioData-CellLine_annotated

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PMC11755467
--output-processed-read: Option to output processed read files.
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PMC9895440
For this purpose, we generated T2 tumor cells with a double KO of both CD28 ligands CD80 and CD86 (termed “T2 KO”) (Supplementary Fig. 6a).
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PMC10898159
So, it is postulated that in GIST, continuation of IM-based therapy for IM-resistant GIST might facilitate disease progression by promoting the malignant behavior of tumors in an FGF2-dependent manner.
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PMC11748363
Since this type of reaction is also exothermic, the solution of amine and pyridine in anhydrous DCM was cooled in an ice bath before, during, and after the addition of phenylacetyl chloride.
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PMC7351993
First, the pixel size was normalized to a square, leading to an image size of 122 × 89 pixels.
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PMC9065483
Kinase inhibitors that simultaneously prevented vanadate-mediated oncolysis to a threshold of 60% and decreased viral output below a log fold-change threshold of 1.5 are shown in the upper left quadrant of Figure 1B.
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PMC11759543
In summary, the most important information here is the in vivo synergistic anti-tumor effect of the combined doxorubicin and vorinostat treatment (Fig. 8).
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PMC11224206
For a review of regulatory factors, see Baker et al. .
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PMC9429973
Results showed that the levels of apoptosis were significantly lower if compared to conventional 2D cultures (Figure.
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PMC11612794
As these two residues were not included in the binding regions 1 and 2, we re-evaluated the AlphaFold 2 prediction model of Mis12C in complex with the aa 161–216 region of CENP-T. As shown in Figure 5B, S175 and T184 are close to the basic regions of Nsl1 and Pmf1, suggesting that phosphorylation of these CENP-T residues might provide the additional Mis12C binding sites mediated via electrostatic interactions and stabilize the CENP-T-Mis12C interface.
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PMC10847511
Results were replicated in the same analysis restricted to breast and ovarian cancer cell lines (n = 54 and 62) (Figure S4).
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PMC11672617
Following incubation with the test compounds, the cells were harvested, washed with phosphate-salt buffer (PBS), and centrifuged at 400× g for five minutes.
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PMC9412887
More importantly, the tumor regression effect was most significant in the apD-1/CDDP@NP MN group, with a tumor weight of 0.012 ± 0.005 g (Figure 8d).
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PMC10998613
The distribution of the fc value of each individual cell was plotted, and the description of the plot is similar as in Fig. 1E. (
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PMC10955424
Paclitaxel drug resistance was induced in primary OC cells by cancer associated fibroblasts (CAFs) secreting IL-6 via the JAK2/STAT3 signal transduction pathway .
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PMC11704834
Forced expression of E-cadherin in A549GR cells attenuated not only their increased motility (Fig. 4Da and Db) but also gefitinib resistance (Fig. 4Dc).
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PMC7887261
The top three genes with the lowest o/e were bolded: PHF13, TP63, and STAU2.#Genes Phevo PhoRank is based on gene functions relevant to the disease phenotype (LC, COPD/PF) from diverse biomedical ontologies.
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PMC9436459
AMB Amphotericin B, AMP Ampicillin, AMX Amoxicillin, BER Berberine, CIP Ciprofloxacin, ERY Erythromycin, KAN Kanamycin, LNZ Linezolid, MET Methicillin, MIZ Miconazole, OSE Oseltamivir, OXA Oxacillin, VAN Vancomycin Antibacterial activities of MDAAs E faecalis ATCC 29,212 E faecalis ATCC 29,212 B., Bacillus; C., Candida; E., Enterococcus; E.*, Escherichia; M., Micrococcus; P., Porphlococcus; S., Staphylococcus; S.*, Saccaromyces; S.**, Salmonella; S.***, Streptococcus; MRSA, methicillin-resistant S. aureus; MSSA, methicillin-sensitive S. aureus; VRE, vancomycin-resistant enterococci.
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PMC10713411
Furthermore, to further validate the role of PCD in RCC, a landscape map covering eight indicators (DEGs, OS, uni-Cox, multi-Cox, Lasso-genes, Coexpression, Pathway and PPI) of 17 PRPCDGs was constructed.
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PMC9429973
Tabelecleucel has shown promising outcomes (Prockop JCI 2020).
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PMC11609529
Apoptotic cells were assessed through Annexin V/PI staining (C), and cell cycle analysis was performed using PI staining (D) (n = 3, mean ± SD). (
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PMC11476106
Cell and cluster quantity and morphology in H&E and anti-VN stainings from 2D and 3D models were subjectively evaluated by expert observers, including the reference pathologist of the group (SN), who also validated the objective digital analyses.
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PMC11496491
Table 7Specific information of the top 20 signaling pathways with the most significant KEGG enrichment.
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PMC9219615
Treatment of HeLa with Tpz-1 resulted in multipolar spindle formation (Figure 7).
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PMC11772449
The cells were fixed with paraformaldehyde (20 min) and treated with TritonX-100 (0.2%) for 15 min.
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PMC10213199
Fig. 6Fig.
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PMC9096373
Tumor-bearing mice were randomly divided into 4 groups, including the control group (n=12), where mice received intragastric normal saline from days 1–7 after enrollment at a rate of 0.1 mL/day.
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PMC9429973
Quality of life was assessed using SF-36 questionnaire, while Convenience and Satisfaction of anticoagulant treatment were assessed based on the Perception of Anticoagulation Treatment Questionnaire 2 (PACT-Q2).
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PMC8956657
Future studies will be aimed towards understanding how ORF4b proteins of related merbcoviruses bind to IMPα.
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PMC11295144
However, in the presence of α4β3δ-GABAARs, NL2 had a significantly greater effect (median = 0.52%; IQR = 0.18 - 0.95%; n = 21 cells; from N = 2 independent experiments, p = 0.0006; Figures 4B,D).
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PMC11628309
This circumstance poses several challenges because the number of affected people is expected to increase dramatically in the following decades (Jaul and Barron, 2017; Martinez et al., 2021).
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PMC6102174
B–D, from which five new patchoulane-type sesquiterpenoids, cyperene-3,8-dione (126), 14-hydroxycyperotundone (127), 14-acetoxycyperotundone (128), 3β-hydroxycyperenoicacid (129) and sugetriol-3,9-diacetate (130), along with 32 known ones were obtained.
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PMC11754784
The AFM characterizations were carried out on a Bruker Multimode V8 Scanning Probe Microscope (Bruker, Bremen, Germany).
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PMC11365427
Insufficient phenylalanine can inhibit cell proliferation, cause cell cycle arrest, and induce apoptosis.
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PMC11144382
NFIX, located on chromosome 19p13.2, contains 11 exons and encodes 14 transcripts through differential splicing and the use of different transcription initiation sites, of which 11 are protein coding.
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PMC9856122
Some alkaloids categorized under this division were evaluated for various viral targets and produced effective results.
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PMC11632064
Gene functional classification of “sensitizing” transcripts (negative correlation coefficient ρ) revealed enrichment for translation, ribosome biogenesis, and cell division pathways, while “resistance” transcripts (positive ρ) were enriched for development, metabolic, and pigmentation pathways (Fig 7C).
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PMC11487720
In contrast, POD occurred in MDA-MB-231, MDA-MB-231(NH), and metastatic MDA-MB-231(IV-2–3) cells upon exposure to UV only or UV then cold shock (Fig. 2M-O).
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PMC11352666
Moreover, data from CRISPR-based library screens indicated that EWS cell lines are particularly dependent on MERTK.
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PMC9583612
This is because engineering-based methods rely on component-level activity and emission factors that are often outdated or poorly characterized and emissions from high-emitting or superemitting events are not accounted for.
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PMC9848491
Patients were divided into high-risk and low-risk groups based on median values.
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PMC9587866
This leads to the formation and expansion of tumors (Schwentner et al., 2015).
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PMC11711345
Because of the promising cancer antiproliferation of the compounds in this study, an in silico evaluation was necessary to determine their drug-likeness and ADMET properties.
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PMC8193046
Computational approaches are great tools for lead discovery and subsequent optimization with the support of organic synthesis.
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PMC11297139
FRAP was performed using a Zeiss LSM700 microscope with a 594 nm laser.
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PMC9429973
The aim of this article is to bring awareness to the wider community about the possible association of vaccination in the context of acute thrombosis.
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PMC11429241
COL1A1 (Collagen Type I Alpha 1 Chain) is a major component of the extracellular matrix, providing structural support to tissues and playing a role in cell signaling.
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PMC9429973
However, its effects in the modulation of therapeutic compounds in AML is not well understood.
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PMC10747160
The 96-well plate was then returned to the 37 °C humidified incubator at 4.5% CO2 in order to allow the captured pseudovirions to infect the adhered 293 cells.
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PMC9429973
However, the presentation of such MAPs after AZA treatment has not been firmly demonstrated thus far.
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PMC7192625
For example, we have recently introduced the concept of chromatin assortativity (ChAs), which allows us to identify whether chromatin with specific features (chromatin marks, binding of transcription factors and replication timing, amongst others) tends to form preferential 3D contacts in the nucleus (25,42).
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PMC11297139
Bars represents mean ± SEM; n = 3 technical replicates; **p < 0.01, ***p < 0.001, NS non-significant.
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PMC11401350
However, more central memory but not effector memory cells were detected in CAR + versus CAR- CD8 T cells at the endpoint (Fig. 5).
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PMC11787355
tumor imaging with preclinical MRI.
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PMC8557138
Hence, developing 3D multicellular tumor vascular models consisting of neurons would unravel the role of these neurotransmitters in the tumoral arena.
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PMC11733919
Prolonged treatment with multifunctionalized nanoplatform also promoted lipid peroxidation-mediated cell death ferroptosis (Figure 7).
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PMC11486946
Uniform illumination was required to quantify the brightness.
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PMC8584666
The percentage of phosphorylated p65-NF-κB was increased in the GPI-80 cell subset of GPI-80-transfected cells as compared with that in mock-transfected cells (Figure 5).
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PMC11790971
In addition, the data inspection and feature interpretation steps provided valuable insights into the relationship between optical properties and phenotypic variations among these cell lines.
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PMC11767793
In particular, the conjugation of polycations to AuNPs gives them a positive charge that ensures an electrostatic interaction with the negatively charged cellular membranes and eases the particle cellular internalization .
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PMC11596967
Chinese Hamster Ovary (CHO)-K1 cell lines were obtained from the American Type Culture Collection (ATCC; Manassas, VA, USA).
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PMC9587298
Among the different dicarbonyl compounds, methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-dG), MGO is the most studied as it is one of the most cytotoxic and reactive compounds (Huang, Chuang, Wu, & Yen, 2008).
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PMC10568263
After the complex formation of anti-HSP70 and HSP70, the redox current of HSP70/BSA/anti/EN-LC/Au@MnO2/MoO3/SPE showed a decreasing trend.
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PMC10919056
Presently, 35 genetic diseases in humans are known to result from mutations in 11 different GJPs (16, 17).
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PMC10772747
Cells were exposed to Eleutherine bulbosa, doxorubicin, and 1,4 naphthoquinone for 24 hours.
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PMC11435360
Seeded in 6-well plates were 5637 cells (2 × 10 cells/well).
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PMC11711871
Additionally, sex-specific salt sensitivity was reported following high-salt diet in female Balb/c mice resulting in impaired endothelium-dependent vasodilation and in male C57Bl/6J mice exhibiting sympathetic overactivity without renal sodium retention .
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PMC11653552
These interactions can lead to the degradation of target mRNAs or inhibit their translation, thus influencing various cellular processes .
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PMC7840816
Cells were transfected with siRNA-SOX9 or siRNA-scramble using Lipofectamine 2000 (Invitrogen) following the manufacturer’s instructions.
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PMC11765879
Indeed, phenolic compounds and flavonoids exhibit substantial anti-cancer properties, which support the anti-cancer potential of ZSC species .
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PMC4270159
β-tubulin [additional control].
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PMC11457557
Mirna 21 induces renal cell hypertrophy, and matrix expansion as its overexpression lowers PTEN levels and increases Akt phosphorylation, all of which can contribute to the pathologic characteristics of DKD.
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PMC10605143
We showed that the mesenchymal phenotype resulting from HSF1 overexpression in human mammary epithelial cells is associated with enhanced migratory capacity, expression of vimentin and down-regulation of CDH1, and enrichment of the population of invasive mesenchymal CD44/CD24 cells.
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PMC9429973
We defined the disease stage according to Ann Arbor staging system.
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PMC11290772
To provide further clarity, the ovarian cancer organoids were subjected to Live/Dead cell fluorescence staining prior to their co-culture with NK cells.
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PMC10667689
Also, Samudio et al. demonstrated that inhibition of CPT-1A results in enhanced sensitivity to cytotoxic agents in AML cells, probably based on the role of FAO in controlling mitochondrial permeability dependent on B-cell lymphoma 2 antagonist/killer (BAK) (74).
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PMC10237474
All proteins achieved > 90% purity as shown by SDS-PAGE and analytical SEC analysis except for protein 7 expressed from Expi293F GnTI and protein 8 expressed from HEK293S GnTI (Figs 5 and 6; Table 1).
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PMC9429973
Drug combination resulted in a reduction of both OPN plasmatic levels and bone marrow fibrosis development.
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PMC9220170
The opposite effect of SELENOM and SELENOT knockdowns on the expression of pro-apoptotic genes was revealed.
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PMC9429973
In PMF, chromatin structure, RNA splicing and DNA methylation were the most recurrently involved pathway and ASXL1 and TET2 were the most frequently mutated genes.
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PMC10933092
However, MIBC usually relapses and progresses (Lenis et al., 2020; Patel et al., 2020).
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PMC11281366
We also validated the mRNA-seq data and found that CD59 mRNA levels are indeed increased in GFP-positive relative to uninfected primary CD4 T cells (FC = 2.1-fold, p = 0.0022) (Figure 3B).
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PMC10940855
Affymetrix Transcriptome Analysis Console (TAC) software was used to analyze the differential gene expression between the cell types.
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PMC7519871
Many compounds have been found to inhibit early stages of carcinogenesis in experimental models.
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PMC11240571
Given this, we hypothesized that exosomal PD-L1 is released from bone and soft tissue sarcoma cells, exerting an inhibitory influence on immune cells.
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PMC9429973
In contrast, more patients received active treatment (78% vs. 48%; p=<0.001) in the vaccinated cohort.
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PMC11653168
While pro-caspase-3 levels remained relatively stable, cleaved caspase-3 exhibited a slight increase at 16 h. LC3B levels also demonstrated a significant increase at 8,16 and 24 h. Similarly, p62 levels showed a decreasing trend at 24 h, indicating autophagy activation, though less prominent compared with in CCRF-CEM cells.
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PMC9429973
A Prophylaxis had been prescribed for 10 patients (62.5%): 8 were classified as high risk, and 2 had obesity.
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PMC2944824
Caspase-3 activity was measured as described in figure 1 (A) in homogenates. ***
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PMC10047551
Data concerning the cell lines are presented as the mean with error bars as the standard deviation.
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PMC11013014
Based on the comparison between EA and the synthesised compounds 2 and 3, we found that compound 2 has more interactions than EA, which enhances its inhibitory activity.
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PMC11761919
In this study, the NICE expression system was used to express the Fiber2 protein of fowl adenovirus serotype 4 (FAdV-4), initiated by the PnisA promoter using nisin as an inducer.
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PMC11718817
Furthermore, pancreatic cancer cells are characterized by exceptionally low antigenicity, resulting from low mutational burden and absence of neoantigens .
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PMC11798926
Images were acquired on a Leica SP8 instrument in confocal mode with a 63x objective and z stack images were taken through the entire cell volume.
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PMC11566417
Single colonies were then isolated and allowed to expand separately in EpSC medium.
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PMC10698968
Histologically, MFS is characterised by atypical spindle cells immersed in a gelatinous myxoid matrix with a tendency of multinodular and lobular growth and with curvilinear vessels [4–9].
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PMC11585565
For a small sample study, a non-parametric statistical analysis was applied.
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PMC11361748
Cut-offs were arbitrarily set at the 95th percentile for a high TAR11 score and at the 75th percentile for a medium TAR11 score based on the distributions shown in A and D. The source data used to derive the numerical values reported here can be found in S1 Data.
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PMC10335954
The prognosis of the patients with gastric malignancy was further analyzed to show that the survival rate of the TRIP13 overexpression group was worse than that of the under-expression group (hazard ratio [HR]: 1.25, P < 0.05; Fig. 1D).
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PMC10197932
P values less than 0.05 were considered statistically significant in this study.
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