Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC8336407
These leaves contain arbutin which is a glucoside of hydroquinone .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "leaves", "contain", "arbutin", "which", "is", "a", "glucoside", "of", "hydroquinone", "." ] } ]
PMC8567602
29–31).
[ { "tags": [ "O", "O", "O" ], "tokens": [ "29–31", ")", "." ] } ]
PMC11786767
F and G: Reduced Ki-67 phosphorylation and Ki-67 protein levels both influence sister chromatin separation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", "and", "G", ":", "Reduced", "Ki-67", "phosphorylation", "and", "Ki-67", "protein", "levels", "both", "influence", "sister", "chromatin", "separation", "." ] } ]
PMC7612475
Importantly, in keeping with the previously reported impact of SF3B1 mutation on cryptic 3′-splice site usage, this knock-in cell line expresses a number of altered transcripts in common with those expressed in patient derived SF3B1 tumor cells (16).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", "in", "keeping", "with", "the", "previously", "reported", "impact", "of", "SF3B1", "mutation", "on", "cryptic", "3′-splice", "site", "usage", ",", "this", "knock-in", "cell", "line", "expresses", "a", "number", "of", "altered", "transcripts", "in", "common", "with", "those", "expressed", "in", "patient", "derived", "SF3B1", "tumor", "cells", "(", "16", ")", "." ] } ]
PMC9884169
Bladder cancer (BCa) is one of the most common malignant tumors in urology .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bladder", "cancer", "(", "BCa", ")", "is", "one", "of", "the", "most", "common", "malignant", "tumors", "in", "urology", "." ] } ]
PMC11248911
Equilibration is done in two phases: NVT ensemble and NPT ensemble to ensure that the system has achieved the desired temperature and pressure.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Equilibration", "is", "done", "in", "two", "phases", ":", "NVT", "ensemble", "and", "NPT", "ensemble", "to", "ensure", "that", "the", "system", "has", "achieved", "the", "desired", "temperature", "and", "pressure", "." ] } ]
PMC9985266
A cDNA synthesis kit (Vazyme, Nanjing, China) was used to reverse transcribe 2 μg of mRNA into cDNA, and then the cDNA was used as the amplification template in a SYBR reaction system (Vazyme, Nanjing, China).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "cDNA", "synthesis", "kit", "(", "Vazyme", ",", "Nanjing", ",", "China", ")", "was", "used", "to", "reverse", "transcribe", "2", "μg", "of", "mRNA", "into", "cDNA", ",", "and", "then", "the", "cDNA", "was", "used", "as", "the", "amplification", "template", "in", "a", "SYBR", "reaction", "system", "(", "Vazyme", ",", "Nanjing", ",", "China", ")", "." ] } ]
PMC11361748
Future studies are needed to test and refine the “TAR11” signature and assess whether enhanced PKCα activity, in particular, plays a significant role in the genesis and/or maintenance of skin lesions in disorders such as PSOR, HS, AD, and others.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Future", "studies", "are", "needed", "to", "test", "and", "refine", "the", "“", "TAR11", "”", "signature", "and", "assess", "whether", "enhanced", "PKCα", "activity", ",", "in", "particular", ",", "plays", "a", "significant", "role", "in", "the", "genesis", "and/or", "maintenance", "of", "skin", "lesions", "in", "disorders", "such", "as", "PSOR", ",", "HS", ",", "AD", ",", "and", "others", "." ] } ]
PMC11496728
Protein levels were verified by Western blot.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "levels", "were", "verified", "by", "Western", "blot", "." ] } ]
PMC11610461
The connection of PSENEN expression level with TNM stage in the GSE150404 database (I: n = 15, II: n = 15, III: n = 15, IV: n = 15). “*”, “**”
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "connection", "of", "PSENEN", "expression", "level", "with", "TNM", "stage", "in", "the", "GSE150404", "database", "(", "I", ":", "n", "=", "15", ",", "II", ":", "n", "=", "15", ",", "III", ":", "n", "=", "15", ",", "IV", ":", "n", "=", "15", ")", ".", "“", "*", "”", ",", "“", "*", "*", "”" ] } ]
PMC9429973
Methods: We designed several homology directed repair (HDR) editing strategies that would correct the genetic defect.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "We", "designed", "several", "homology", "directed", "repair", "(", "HDR", ")", "editing", "strategies", "that", "would", "correct", "the", "genetic", "defect", "." ] } ]
PMC10545062
At T75, the balloon catheter was removed and each animal was randomized to standardized critical care (SCC) or standardized critical care plus (SCC+) (Supplemental Digital Content, Figure 1, http://links.lww.com/TA/D127).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "T75", ",", "the", "balloon", "catheter", "was", "removed", "and", "each", "animal", "was", "randomized", "to", "standardized", "critical", "care", "(", "SCC", ")", "or", "standardized", "critical", "care", "plus", "(", "SCC+", ")", "(", "Supplemental", "Digital", "Content", ",", "Figure", "1", ",", "http://links.lww.com/TA/D127", ")", "." ] } ]
PMC11173119
PBMCs of a patient with FMF were isolated as described previously .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PBMCs", "of", "a", "patient", "with", "FMF", "were", "isolated", "as", "described", "previously", "." ] } ]
PMC9429973
Of the 6 pts who had never been transfused, 3 (50.0%) had received chelation therapy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "the", "6", "pts", "who", "had", "never", "been", "transfused", ",", "3", "(", "50.0", "%", ")", "had", "received", "chelation", "therapy", "." ] } ]
PMC8526701
After washing with TBST three times, the blots were incubated with secondary antibodies.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "washing", "with", "TBST", "three", "times", ",", "the", "blots", "were", "incubated", "with", "secondary", "antibodies", "." ] } ]
PMC3995603
CSS, HSL, JKL and MYL carried out the experiments.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CSS", ",", "HSL", ",", "JKL", "and", "MYL", "carried", "out", "the", "experiments", "." ] } ]
PMC11762280
ns not significant.
[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "ns", "not", "significant", "." ] } ]
PMC11634027
Nonetheless, co-immunoprecipitation experiments confirmed that key partners of Drosophila Ds, including Lft, Dachs, MyoID and Sple, could associate with the DCHS1 ICD in cultured cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nonetheless", ",", "co-immunoprecipitation", "experiments", "confirmed", "that", "key", "partners", "of", "Drosophila", "Ds", ",", "including", "Lft", ",", "Dachs", ",", "MyoID", "and", "Sple", ",", "could", "associate", "with", "the", "DCHS1", "ICD", "in", "cultured", "cells", "." ] } ]
PMC9429973
With the aim to reduce RI we established pharmacokinetic measurements for fludarabine in addition and combined to the established ones for busulfan.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "the", "aim", "to", "reduce", "RI", "we", "established", "pharmacokinetic", "measurements", "for", "fludarabine", "in", "addition", "and", "combined", "to", "the", "established", "ones", "for", "busulfan", "." ] } ]
PMC9429973
Subcutaneous injection of the cell lines also allowed for the formation of tumors, where tumor weight was largest in mice injected with Cdk6-WT cells, intermediate in the case of Cdk6-K43M cells and lowest in the case of Cdk6-KO cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subcutaneous", "injection", "of", "the", "cell", "lines", "also", "allowed", "for", "the", "formation", "of", "tumors", ",", "where", "tumor", "weight", "was", "largest", "in", "mice", "injected", "with", "Cdk6-WT", "cells", ",", "intermediate", "in", "the", "case", "of", "Cdk6-K43", "M", "cells", "and", "lowest", "in", "the", "case", "of", "Cdk6-KO", "cells", "." ] } ]
PMC9429973
Once again, severe aGVHD was associated with a higher incidence (60% sepsis; p-value <0.001 and 26.5% IFI; p-value 0.001) and an increase was also observed in patients with graft failure (33,5% sepsis, p-value 0.26 and 22% IFI, p-value 0.04).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Once", "again", ",", "severe", "aGVHD", "was", "associated", "with", "a", "higher", "incidence", "(", "60", "%", "sepsis", ";", "p-value", "<", "0.001", "and", "26.5", "%", "IFI", ";", "p-value", "0.001", ")", "and", "an", "increase", "was", "also", "observed", "in", "patients", "with", "graft", "failure", "(", "33,5", "%", "sepsis", ",", "p-value", "0.26", "and", "22", "%", "IFI", ",", "p-value", "0.04", ")", "." ] } ]
PMC11721064
Besides, single-cell sequencing, RNA sequencing, and western blotting have revealed the crucial role of the PI3K/AKT pathway in triggering this process.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Besides", ",", "single-cell", "sequencing", ",", "RNA", "sequencing", ",", "and", "western", "blotting", "have", "revealed", "the", "crucial", "role", "of", "the", "PI3K/AKT", "pathway", "in", "triggering", "this", "process", "." ] } ]
PMC6364197
A total of 100 µl solution was taken for recording the optical density after incubation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "total", "of", "100", "µl", "solution", "was", "taken", "for", "recording", "the", "optical", "density", "after", "incubation", "." ] } ]
PMC9429973
Analyses were done using Western blot, IHC, proximity ligation assay, and in vitro phosphorylation assay.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Analyses", "were", "done", "using", "Western", "blot", ",", "IHC", ",", "proximity", "ligation", "assay", ",", "and", "in", "vitro", "phosphorylation", "assay", "." ] } ]
PMC11209164
All the cell lines used in this study along with information about their suppliers and the growth media are detailed in (Table S1).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "the", "cell", "lines", "used", "in", "this", "study", "along", "with", "information", "about", "their", "suppliers", "and", "the", "growth", "media", "are", "detailed", "in", "(", "Table", "S1", ")", "." ] } ]
PMC11754291
All supplements were added at the concentrations determined and provided by Lonza, except for the geneticin (Goyer et al., 2019).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "supplements", "were", "added", "at", "the", "concentrations", "determined", "and", "provided", "by", "Lonza", ",", "except", "for", "the", "geneticin", "(", "Goyer", "et", "al.", ",", "2019", ")", "." ] } ]
PMC11650848
The human form also demonstrates high ESC expression but in addition is detectable in some somatic tissues .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "human", "form", "also", "demonstrates", "high", "ESC", "expression", "but", "in", "addition", "is", "detectable", "in", "some", "somatic", "tissues", "." ] } ]
PMC11371747
In contrast, hRFC-transfected cells showed IC50 values for the antifolates in the same range as the wild type AA8 cells (Table 5), indicating that under physiological neutral pH conditions, RFC is predominantly responsible for the uptake of antifolates, as well as for l-LV, since protection was very efficient, varying from 72-fold (MTX) to 1462-fold (RTX) (Table 5; Supplementary Figures S3, S4).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "hRFC-transfected", "cells", "showed", "IC50", "values", "for", "the", "antifolates", "in", "the", "same", "range", "as", "the", "wild", "type", "AA8", "cells", "(", "Table", "5", ")", ",", "indicating", "that", "under", "physiological", "neutral", "pH", "conditions", ",", "RFC", "is", "predominantly", "responsible", "for", "the", "uptake", "of", "antifolates", ",", "as", "well", "as", "for", "l-LV", ",", "since", "protection", "was", "very", "efficient", ",", "varying", "from", "72-fold", "(", "MTX", ")", "to", "1462-fold", "(", "RTX", ")", "(", "Table", "5", ";", "Supplementary", "Figures", "S3", ",", "S4", ")", "." ] } ]
PMC11345828
The resultant product was alkylated with MeI following General Procedure D (44 mg, 80% yield)).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resultant", "product", "was", "alkylated", "with", "MeI", "following", "General", "Procedure", "D", "(", "44", "mg", ",", "80", "%", "yield", ")", ")", "." ] } ]
PMC11402217
Funding: This work was supported by 10.13039/501100001809National Natural Science Foundation of China (82174033 to Y.W., 81970761 to H.R.T.).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Funding", ":", "This", "work", "was", "supported", "by", "10.13039/501100001809National", "Natural", "Science", "Foundation", "of", "China", "(", "82174033", "to", "Y.W.", ",", "81970761", "to", "H.R.T.", ")", "." ] } ]
PMC11087766
Mutant phages that exist in the population escape targeting and become the dominant phage in the population. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mutant", "phages", "that", "exist", "in", "the", "population", "escape", "targeting", "and", "become", "the", "dominant", "phage", "in", "the", "population", ".", "(" ] } ]
PMC11782780
We validated that the addition of 2-DG reversed the promotion of glycolysis and stem-like phenotype of BC cells by sh-EBF3.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "validated", "that", "the", "addition", "of", "2-DG", "reversed", "the", "promotion", "of", "glycolysis", "and", "stem-like", "phenotype", "of", "BC", "cells", "by", "sh-EBF3", "." ] } ]
PMC8414691
S2, cytoplasmatic fraction.
[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "S2", ",", "cytoplasmatic", "fraction", "." ] } ]
PMC9429973
The post-hoc test Scheffe has been used to test which groups are different two by two.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "post-hoc", "test", "Scheffe", "has", "been", "used", "to", "test", "which", "groups", "are", "different", "two", "by", "two", "." ] } ]
PMC9429973
LSCs properties are crucially regulated and maintained also through interactions with the bone marrow microenvironment, which includes immune cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LSCs", "properties", "are", "crucially", "regulated", "and", "maintained", "also", "through", "interactions", "with", "the", "bone", "marrow", "microenvironment", ",", "which", "includes", "immune", "cells", "." ] } ]
PMC11194678
To test this hypothesis, we first knocked down STAU1 in the mouse HD STHdh cells with two different shRNAs, and the STAU1 expression levels were considerably downregulated by sh-mSTAU1-1 (Fig. S4 F), which was then used for depleting mSTAU2 in the subsequent experiments.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "test", "this", "hypothesis", ",", "we", "first", "knocked", "down", "STAU1", "in", "the", "mouse", "HD", "STHdh", "cells", "with", "two", "different", "shRNAs", ",", "and", "the", "STAU1", "expression", "levels", "were", "considerably", "downregulated", "by", "sh-mSTAU1", "-", "1", "(", "Fig.", "S4", "F", ")", ",", "which", "was", "then", "used", "for", "depleting", "mSTAU2", "in", "the", "subsequent", "experiments", "." ] } ]
PMC9429973
Consequently, 5-year survival rates are as low as 10-30%, which underscores the urgent medical need for new therapeutic options.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "5-year", "survival", "rates", "are", "as", "low", "as", "10", "-", "30", "%", ",", "which", "underscores", "the", "urgent", "medical", "need", "for", "new", "therapeutic", "options", "." ] } ]
PMC10391797
Finally, the absorbance was detected and IC50 was calculated using Graphpad Prism (V.8).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "the", "absorbance", "was", "detected", "and", "IC50", "was", "calculated", "using", "Graphpad", "Prism", "(", "V.8", ")", "." ] } ]
PMC9250505
The median survival of patients with recurrent EOC ranges from 12–24 months.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "survival", "of", "patients", "with", "recurrent", "EOC", "ranges", "from", "12–24", "months", "." ] } ]
PMC11706491
Excitation lasers used were 405 nm for mTagBFP2, 488 nm for GFP, and 561 nm for mCherry.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Excitation", "lasers", "used", "were", "405", "nm", "for", "mTagBFP2", ",", "488", "nm", "for", "GFP", ",", "and", "561", "nm", "for", "mCherry", "." ] } ]
PMC11486946
Compound treatment was carried out with the indicated compounds for 1 h (dashed bar), and cells were subsequently stimulated with EGF for 2 min (filled bar).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compound", "treatment", "was", "carried", "out", "with", "the", "indicated", "compounds", "for", "1", "h", "(", "dashed", "bar", ")", ",", "and", "cells", "were", "subsequently", "stimulated", "with", "EGF", "for", "2", "min", "(", "filled", "bar", ")", "." ] } ]
PMC9318744
Recently, Hui et al. reported that omicron (B.1.1.529) replicates faster than other SARS-CoV-2 variants in the human bronchi but less efficiently in the lung parenchyma .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recently", ",", "Hui", "et", "al.", "reported", "that", "omicron", "(", "B.1.1.529", ")", "replicates", "faster", "than", "other", "SARS-CoV-2", "variants", "in", "the", "human", "bronchi", "but", "less", "efficiently", "in", "the", "lung", "parenchyma", "." ] } ]
PMC11754432
Silencing of ALOX15B did not result in alteration of other hydroxy-fatty acids, except for 9-HEPE (Fig. S2 A-D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Silencing", "of", "ALOX15B", "did", "not", "result", "in", "alteration", "of", "other", "hydroxy-fatty", "acids", ",", "except", "for", "9-HEPE", "(", "Fig.", "S2", "A-D", ")", "." ] } ]
PMC11786704
Activation of p38 MAPK by ROS leads to the upregulation of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Activation", "of", "p38", "MAPK", "by", "ROS", "leads", "to", "the", "upregulation", "of", "pro-inflammatory", "cytokines", "such", "as", "tumor", "necrosis", "factor-alpha", "(", "TNF-α", ")", ",", "interleukin-1", "beta", "(", "IL-1β", ")", "and", "interleukin-6", "(", "IL-6", ")", "." ] } ]
PMC11697065
A: Diagrams detailing the structure of mAb1 (Monoclonal antibody 1) in blue, BisAb1 (Bispecific antibody 1) and MonoAb1 (Monovalent control for BisAb1) in orange, BisAb2 (Bispecific antibody 2) and MonoAb2 (Monovalent control for BisAb2) in teal.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ":", "Diagrams", "detailing", "the", "structure", "of", "mAb1", "(", "Monoclonal", "antibody", "1", ")", "in", "blue", ",", "BisAb1", "(", "Bispecific", "antibody", "1", ")", "and", "MonoAb1", "(", "Monovalent", "control", "for", "BisAb1", ")", "in", "orange", ",", "BisAb2", "(", "Bispecific", "antibody", "2", ")", "and", "MonoAb2", "(", "Monovalent", "control", "for", "BisAb2", ")", "in", "teal", "." ] } ]
PMC10329074
Bar graphs are the mean ± SD of three separate experiments.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bar", "graphs", "are", "the", "mean", "±", "SD", "of", "three", "separate", "experiments", "." ] } ]
PMC11522251
Reducing HOXB8 levels amplified cetuximab’s suppressive impact on colon cancer cells’ growth, movement, and ability to form colonies (Fig. 4A–D), indicating that colon cancer cells’ cetuximab sensitization is tightly related to the HOXB8-STAT3 axis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reducing", "HOXB8", "levels", "amplified", "cetuximab", "’s", "suppressive", "impact", "on", "colon", "cancer", "cells", "’", "growth", ",", "movement", ",", "and", "ability", "to", "form", "colonies", "(", "Fig.", "4A", "–", "D", ")", ",", "indicating", "that", "colon", "cancer", "cells", "’", "cetuximab", "sensitization", "is", "tightly", "related", "to", "the", "HOXB8-STAT3", "axis", "." ] } ]
PMC9429973
P. Bruno, J. Kanter, J. Ziegler, B. Stuart, J. Ahn, J. Dunn, G. Allen, C. Morabito Fulcrum Therapeutics, Inc., Cambridge; University of Alabama Medical Center, Birmingham, United States of America Background: FTX-6058 is a potent and selective oral small-molecule inhibitor of Embryonic Ectoderm Development (EED) that has demonstrated robust fetal hemoglobin (HbF) protein expression in cell and murine models of Sickle Cell Disease (SCD).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P.", "Bruno", ",", "J.", "Kanter", ",", "J.", "Ziegler", ",", "B.", "Stuart", ",", "J.", "Ahn", ",", "J.", "Dunn", ",", "G.", "Allen", ",", "C.", "Morabito", "Fulcrum", "Therapeutics", ",", "Inc.", ",", "Cambridge", ";", "University", "of", "Alabama", "Medical", "Center", ",", "Birmingham", ",", "United", "States", "of", "America", "Background", ":", "FTX-6058", "is", "a", "potent", "and", "selective", "oral", "small-molecule", "inhibitor", "of", "Embryonic", "Ectoderm", "Development", "(", "EED", ")", "that", "has", "demonstrated", "robust", "fetal", "hemoglobin", "(", "HbF", ")", "protein", "expression", "in", "cell", "and", "murine", "models", "of", "Sickle", "Cell", "Disease", "(", "SCD", ")", "." ] } ]
PMC11046454
CLSM images of CAR-J treated with 50 nM DNA-Cy5 or FITC-DNA-Cy5 in binding buffer at 4 °C for 30 min.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CLSM", "images", "of", "CAR-J", "treated", "with", "50", "nM", "DNA-Cy5", "or", "FITC-DNA-Cy5", "in", "binding", "buffer", "at", "4", "°", "C", "for", "30", "min", "." ] } ]
PMC7185206
Inhibition with ADAM10-specific peptide TIMP-1 and ADAM17-specific function-blocking monoclonal antibody D1A similarly maintained 786-0-PD-L1-GFP surface PD-L1 at 24 h versus vehicle control and prevented sPD-L1 generation (Supplemental Figure 6b).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inhibition", "with", "ADAM10-specific", "peptide", "TIMP-1", "and", "ADAM17-specific", "function-blocking", "monoclonal", "antibody", "D1A", "similarly", "maintained", "786", "-", "0-PD-L1-GFP", "surface", "PD-L1", "at", "24", "h", "versus", "vehicle", "control", "and", "prevented", "sPD-L1", "generation", "(", "Supplemental", "Figure", "6b", ")", "." ] } ]
PMC11252033
Western Blotting analysis of CryZ, including quantitative analysis, in A2780S and A2780R transfected with si-CTR or si-CryZ; the image is representative of three different experiments.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "Blotting", "analysis", "of", "CryZ", ",", "including", "quantitative", "analysis", ",", "in", "A2780S", "and", "A2780R", "transfected", "with", "si-CTR", "or", "si-CryZ", ";", "the", "image", "is", "representative", "of", "three", "different", "experiments", "." ] } ]
PMC8143558
In the two examples above, the aqueous extracts had higher quantities compared to the ethanolic extracts for the roots, and the opposite is true for the leaves.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "two", "examples", "above", ",", "the", "aqueous", "extracts", "had", "higher", "quantities", "compared", "to", "the", "ethanolic", "extracts", "for", "the", "roots", ",", "and", "the", "opposite", "is", "true", "for", "the", "leaves", "." ] } ]
PMC11727145
Historically, the concept of DED emerged from research in regenerative medicine, but more importantly, for direct use of the prepared dermal tissues for clinical application to help cover large surface wounds .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Historically", ",", "the", "concept", "of", "DED", "emerged", "from", "research", "in", "regenerative", "medicine", ",", "but", "more", "importantly", ",", "for", "direct", "use", "of", "the", "prepared", "dermal", "tissues", "for", "clinical", "application", "to", "help", "cover", "large", "surface", "wounds", "." ] } ]
PMC11638764
We used median normalization and differential expression analysis, with a log2 fold change of 1 and a p-value of 0.05 as cutoffs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "median", "normalization", "and", "differential", "expression", "analysis", ",", "with", "a", "log2", "fold", "change", "of", "1", "and", "a", "p-value", "of", "0.05", "as", "cutoffs", "." ] } ]
PMC10898159
Therapeutic strategies of TKIs targeting KIT mutations in gastrointestinal stromal tumors: fist-line therapy-Imatinib; second-line therapy-Sunitinib; third-line therapy-Regorafenib; fourth-line therapy-Ripretinib.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therapeutic", "strategies", "of", "TKIs", "targeting", "KIT", "mutations", "in", "gastrointestinal", "stromal", "tumors", ":", "fist-line", "therapy-Imatinib", ";", "second-line", "therapy-Sunitinib", ";", "third-line", "therapy-Regorafenib", ";", "fourth-line", "therapy-Ripretinib", "." ] } ]
PMC11394386
Additionally, mutations in the PIK3CA gene, which promote PI3K overexpression, have been identified in up to 36% of CC cases .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "mutations", "in", "the", "PIK3CA", "gene", ",", "which", "promote", "PI3", "K", "overexpression", ",", "have", "been", "identified", "in", "up", "to", "36", "%", "of", "CC", "cases", "." ] } ]
PMC10940855
Sequencing was performed on NovaSeq 6000 for PE 2×150 bp run.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sequencing", "was", "performed", "on", "NovaSeq", "6000", "for", "PE", "2", "×", "150", "bp", "run", "." ] } ]
PMC9219615
Despite their documented antitumor effects, thienopyrazole-based compounds remain an underexplored class of molecules.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "their", "documented", "antitumor", "effects", ",", "thienopyrazole-based", "compounds", "remain", "an", "underexplored", "class", "of", "molecules", "." ] } ]
PMC11013014
Regarding compound 24, the synthesis was carried out through a two-step sequence from EA according to Scheme 3.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regarding", "compound", "24", ",", "the", "synthesis", "was", "carried", "out", "through", "a", "two-step", "sequence", "from", "EA", "according", "to", "Scheme", "3", "." ] } ]
PMC9429973
Lactate (20 mM) and MF-sera exposition induced extracellular matrix (ECM) reorganization as supported by increased level of metalloproteases (MMP9, MMP2) together with reticulin and collagen deposition.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lactate", "(", "20", "mM", ")", "and", "MF-sera", "exposition", "induced", "extracellular", "matrix", "(", "ECM", ")", "reorganization", "as", "supported", "by", "increased", "level", "of", "metalloproteases", "(", "MMP9", ",", "MMP2", ")", "together", "with", "reticulin", "and", "collagen", "deposition", "." ] } ]
PMC7762347
At the end of the incubation, 20% of fresh MTS: PMS mixture (20:1) was added to treated cells and incubated for 3 h. The viability of cells was evaluated by measuring the optical density (490 nm) using a spectrofluorimeter (Sinergy Mx, BioTek, Winooski, VT, USA), which correlates to the amount of viable cells that are able to reduce tetrazolium to formazan.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "end", "of", "the", "incubation", ",", "20", "%", "of", "fresh", "MTS", ":", "PMS", "mixture", "(", "20:1", ")", "was", "added", "to", "treated", "cells", "and", "incubated", "for", "3", "h.", "The", "viability", "of", "cells", "was", "evaluated", "by", "measuring", "the", "optical", "density", "(", "490", "nm", ")", "using", "a", "spectrofluorimeter", "(", "Sinergy", "Mx", ",", "BioTek", ",", "Winooski", ",", "VT", ",", "USA", ")", ",", "which", "correlates", "to", "the", "amount", "of", "viable", "cells", "that", "are", "able", "to", "reduce", "tetrazolium", "to", "formazan", "." ] } ]
PMC11699465
The functional enrichment analysis was done with cluster Profiler.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "functional", "enrichment", "analysis", "was", "done", "with", "cluster", "Profiler", "." ] } ]
PMC10547921
It was approved by the FDA on January 26, 2018.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "approved", "by", "the", "FDA", "on", "January", "26", ",", "2018", "." ] } ]
PMC6684588
administration of ACE-083 in the gastrocnemius muscle of C57BL/6J mice (Jax #000664) twice weekly for 4 weeks increased the weight of the injected muscle in a dose-dependent manner (Fig. 2a).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "administration", "of", "ACE-083", "in", "the", "gastrocnemius", "muscle", "of", "C57BL/6J", "mice", "(", "Jax", "#", "000664", ")", "twice", "weekly", "for", "4", "weeks", "increased", "the", "weight", "of", "the", "injected", "muscle", "in", "a", "dose-dependent", "manner", "(", "Fig.", "2a", ")", "." ] } ]
PMC11066331
The hierarchical cluster analysis identified groups based on the similarity of mass spectra fingerprints.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "hierarchical", "cluster", "analysis", "identified", "groups", "based", "on", "the", "similarity", "of", "mass", "spectra", "fingerprints", "." ] } ]
PMC11591038
We have also shown before that HIF-1 induction with cobalt chloride or DFO can protect rat C6 glioma cells against metabolic insults induced by the irreversible mitochondrial inhibitor 3-NP .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have", "also", "shown", "before", "that", "HIF-1", "induction", "with", "cobalt", "chloride", "or", "DFO", "can", "protect", "rat", "C6", "glioma", "cells", "against", "metabolic", "insults", "induced", "by", "the", "irreversible", "mitochondrial", "inhibitor", "3-NP", "." ] } ]
PMC11745600
A, The target sequence of platinum TALEN in the insulin1 and insulin2 loci of the mouse.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ",", "The", "target", "sequence", "of", "platinum", "TALEN", "in", "the", "insulin1", "and", "insulin2", "loci", "of", "the", "mouse", "." ] } ]
PMC11173119
Genetic analysis of the patient revealed a pathogenic homozygous missense mutation c.2080A>G (p.M694V, rs61752717) in exon 10 of the MEFV gene.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genetic", "analysis", "of", "the", "patient", "revealed", "a", "pathogenic", "homozygous", "missense", "mutation", "c.2080A", ">", "G", "(", "p.", "M694V", ",", "rs61752717", ")", "in", "exon", "10", "of", "the", "MEFV", "gene", "." ] } ]
PMC7757104
However, the contribution of specific OPN-SIs to the regulation of P-gp expression has not been previously addressed.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "contribution", "of", "specific", "OPN-SIs", "to", "the", "regulation", "of", "P-gp", "expression", "has", "not", "been", "previously", "addressed", "." ] } ]
PMC11088135
D Western blot assay was conducted to analyze the protein expression of Bax and Bcl-2.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "Western", "blot", "assay", "was", "conducted", "to", "analyze", "the", "protein", "expression", "of", "Bax", "and", "Bcl-2", "." ] } ]
PMC8753818
Chinese hamster ovary cell line has been used routinely as a bioproduction factory of numerous biopharmaceuticals.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chinese", "hamster", "ovary", "cell", "line", "has", "been", "used", "routinely", "as", "a", "bioproduction", "factory", "of", "numerous", "biopharmaceuticals", "." ] } ]
PMC9429973
In group 1, 12 patients had a diagnosis of multiple myeloma (MM) and 13 of non Hodgkin’s lymphoma (NHL), whereas in group 2, 17 patients were affected by MM, 6 by Hodgkin’s lymphoma (HL) and 7 by NHL.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "group", "1", ",", "12", "patients", "had", "a", "diagnosis", "of", "multiple", "myeloma", "(", "MM", ")", "and", "13", "of", "non", "Hodgkin", "’s", "lymphoma", "(", "NHL", ")", ",", "whereas", "in", "group", "2", ",", "17", "patients", "were", "affected", "by", "MM", ",", "6", "by", "Hodgkin", "’s", "lymphoma", "(", "HL", ")", "and", "7", "by", "NHL", "." ] } ]
PMC11106977
Nagai-Singer et al. demonstrated that NOD-like receptor (NLR) X1 (NLRX1) suppresses pro-inflammatory NF-κB signaling and blocks downstream pro-inflammatory factors .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nagai-Singer", "et", "al.", "demonstrated", "that", "NOD-like", "receptor", "(", "NLR", ")", "X1", "(", "NLRX1", ")", "suppresses", "pro-inflammatory", "NF-κB", "signaling", "and", "blocks", "downstream", "pro-inflammatory", "factors", "." ] } ]
PMC9429973
Aims: Further exploration of the regimen in r/r DLBCL is warranted to confirm and extend these encouraging results and to clarify the relative contributions of the constituent components of the combination regimen.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "Further", "exploration", "of", "the", "regimen", "in", "r/r", "DLBCL", "is", "warranted", "to", "confirm", "and", "extend", "these", "encouraging", "results", "and", "to", "clarify", "the", "relative", "contributions", "of", "the", "constituent", "components", "of", "the", "combination", "regimen", "." ] } ]
PMC9429973
The benefits in the cost-effectiveness model (CEM) were measured in terms of total discounted QALYs which were 5.634 for VenG, 5.350 for ClbG, 4.996 for BR and 5.161 for IBR.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "benefits", "in", "the", "cost-effectiveness", "model", "(", "CEM", ")", "were", "measured", "in", "terms", "of", "total", "discounted", "QALYs", "which", "were", "5.634", "for", "VenG", ",", "5.350", "for", "ClbG", ",", "4.996", "for", "BR", "and", "5.161", "for", "IBR", "." ] } ]
PMC11767817
Interestingly, compound 2a increased phospho-Akt while compound 2a-B decreased total Akt and phospho-Akt in 5637 cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Interestingly", ",", "compound", "2a", "increased", "phospho-Akt", "while", "compound", "2a-B", "decreased", "total", "Akt", "and", "phospho-Akt", "in", "5637", "cells", "." ] } ]
PMC9429973
Results showed that the expression level of CPT-1 was significantly lower in GR-siRNA treated MDSCs (GR-MDSCs) than that in NC-siRNA treated MDSCs (NC-MDSCs), indicating that the decreased expression of CPT-1 was affected by down-regulated GR in MDSCs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "showed", "that", "the", "expression", "level", "of", "CPT-1", "was", "significantly", "lower", "in", "GR-siRNA", "treated", "MDSCs", "(", "GR-MDSCs", ")", "than", "that", "in", "NC-siRNA", "treated", "MDSCs", "(", "NC-MDSCs", ")", ",", "indicating", "that", "the", "decreased", "expression", "of", "CPT-1", "was", "affected", "by", "down-regulated", "GR", "in", "MDSCs", "." ] } ]
PMC11365427
Data are shown as mean ± SEM; n = 5.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "shown", "as", "mean", "±", "SEM", ";", "n", "=", "5", "." ] } ]
PMC11763764
The Affymetrix GeneChip HTA 2.0 microarray (Thermo Fisher Scientific, Waltham, MA, USA) was used for the analysis and results were visualized using Transcriptome Analysis Console (TAC) 4.0.2.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Affymetrix", "GeneChip", "HTA", "2.0", "microarray", "(", "Thermo", "Fisher", "Scientific", ",", "Waltham", ",", "MA", ",", "USA", ")", "was", "used", "for", "the", "analysis", "and", "results", "were", "visualized", "using", "Transcriptome", "Analysis", "Console", "(", "TAC", ")", "4.0.2", "." ] } ]
PMC9844987
The resulting importance scores were supplied to TF-MoDISco (Transcription Factor Motif Discovery from Importance Scores) (Shrikumar, 2020) to identify DNA stretches (seqlets) with high importance for the predictions.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resulting", "importance", "scores", "were", "supplied", "to", "TF-MoDISco", "(", "Transcription", "Factor", "Motif", "Discovery", "from", "Importance", "Scores", ")", "(", "Shrikumar", ",", "2020", ")", "to", "identify", "DNA", "stretches", "(", "seqlets", ")", "with", "high", "importance", "for", "the", "predictions", "." ] } ]
PMC9429973
Methods: We measured anti-receptor binding domain (RBD) IgG after two doses of BNT162b2 in 179 patients (MM: n=78, B-CLL: n=101) and 179 age and sex matched healthy controls up to six months after first vaccination.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "We", "measured", "anti-receptor", "binding", "domain", "(", "RBD", ")", "IgG", "after", "two", "doses", "of", "BNT162b2", "in", "179", "patients", "(", "MM", ":", "n=78", ",", "B-CLL", ":", "n=101", ")", "and", "179", "age", "and", "sex", "matched", "healthy", "controls", "up", "to", "six", "months", "after", "first", "vaccination", "." ] } ]
PMC11627133
The colocalization of GFP and SpyRho fluorescence indicates the successful imaging of the subcellular structures by the AP3‐RhoBAST bifunctional aptamer (Figure 3).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "colocalization", "of", "GFP", "and", "SpyRho", "fluorescence", "indicates", "the", "successful", "imaging", "of", "the", "subcellular", "structures", "by", "the", "AP3‐RhoBAST", "bifunctional", "aptamer", "(", "Figure", "3", ")", "." ] } ]
PMC6835428
The primary intervention for HGSOC is based on the use of surgery with the aim to remove the macroscopic lesions including metastasis , which are, as mentioned above, predominantly localized in the omentum.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "intervention", "for", "HGSOC", "is", "based", "on", "the", "use", "of", "surgery", "with", "the", "aim", "to", "remove", "the", "macroscopic", "lesions", "including", "metastasis", ",", "which", "are", ",", "as", "mentioned", "above", ",", "predominantly", "localized", "in", "the", "omentum", "." ] } ]
PMC11484188
Autophagy is a physiological process that involves cells destroying and recycling their own non-essential or damaged parts (28).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Autophagy", "is", "a", "physiological", "process", "that", "involves", "cells", "destroying", "and", "recycling", "their", "own", "non-essential", "or", "damaged", "parts", "(", "28", ")", "." ] } ]
PMC9429973
Moreover, rapid responses shown with the combination, allow us to identificate those patients who may benefit from this approach.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "rapid", "responses", "shown", "with", "the", "combination", ",", "allow", "us", "to", "identificate", "those", "patients", "who", "may", "benefit", "from", "this", "approach", "." ] } ]
PMC7090062
P < 0.001.
[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.001", "." ] } ]
PMC8336407
HepG2 cells were plated in 24 multi-well flat-bottom culture plates, at 1.7 × 10 cells per well and incubated (37 °C with 5% CO2 and 95% humidity) for 48 h. HepG2 cells were then divided into 16 groups each including 5 wells.
[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HepG2", "cells", "were", "plated", "in", "24", "multi-well", "flat-bottom", "culture", "plates", ",", "at", "1.7", "×", "10", "cells", "per", "well", "and", "incubated", "(", "37", "°", "C", "with", "5", "%", "CO2", "and", "95", "%", "humidity", ")", "for", "48", "h.", "HepG2", "cells", "were", "then", "divided", "into", "16", "groups", "each", "including", "5", "wells", "." ] } ]
PMC5363531
Dasatinib effect on TS expression suggests a role as a sensitizer to PEM treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dasatinib", "effect", "on", "TS", "expression", "suggests", "a", "role", "as", "a", "sensitizer", "to", "PEM", "treatment", "." ] } ]
PMC9910796
As shown in Fig 1D, protein pEP84R was mainly detected in the membrane fraction, as was transmembrane viral protein pE248R, but not cytosolic cellular kinase AKT.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "shown", "in", "Fig", "1D", ",", "protein", "pEP84R", "was", "mainly", "detected", "in", "the", "membrane", "fraction", ",", "as", "was", "transmembrane", "viral", "protein", "pE248R", ",", "but", "not", "cytosolic", "cellular", "kinase", "AKT", "." ] } ]
PMC11706297
The final product was crystallized from ethanol [43–46] (Spectral Data: Supplementary Information.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "final", "product", "was", "crystallized", "from", "ethanol", "[", "43–46", "]", "(", "Spectral", "Data", ":", "Supplementary", "Information", "." ] } ]
PMC11583690
After determining the solvent type, initial DTX concentration, and the optimal drug-to-nanomaterial ratio, an experiment similar to the above-described solvent influence analysis was conducted.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "determining", "the", "solvent", "type", ",", "initial", "DTX", "concentration", ",", "and", "the", "optimal", "drug-to-nanomaterial", "ratio", ",", "an", "experiment", "similar", "to", "the", "above-described", "solvent", "influence", "analysis", "was", "conducted", "." ] } ]
PMC9429973
5-OS was also better in the ACM group than in the SC group in patients with CLL with a median number of previous lines of therapy equal to 1 (p<0.0001) and in patients with a median number of chemotherapy lines equal to 4 (p<0.0001), in patients with genetic abnormalities (p=0.004) and pretreated with fludarabine and/or anthracyclines (p < 0.0001).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "5-OS", "was", "also", "better", "in", "the", "ACM", "group", "than", "in", "the", "SC", "group", "in", "patients", "with", "CLL", "with", "a", "median", "number", "of", "previous", "lines", "of", "therapy", "equal", "to", "1", "(", "p<0.0001", ")", "and", "in", "patients", "with", "a", "median", "number", "of", "chemotherapy", "lines", "equal", "to", "4", "(", "p<0.0001", ")", ",", "in", "patients", "with", "genetic", "abnormalities", "(", "p=0.004", ")", "and", "pretreated", "with", "fludarabine", "and/or", "anthracyclines", "(", "p", "<", "0.0001", ")", "." ] } ]
PMC11473750
Co-immunofluorescence using DAPI, anti-RNF121, anti-MYCN, and anti-GM130 demonstrated that MYCN and RNF121 co-localise to the cis-Golgi but MYCN is mostly found in the nucleus (Fig S2c).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Co-immunofluorescence", "using", "DAPI", ",", "anti-RNF121", ",", "anti-MYCN", ",", "and", "anti-GM130", "demonstrated", "that", "MYCN", "and", "RNF121", "co-localise", "to", "the", "cis-Golgi", "but", "MYCN", "is", "mostly", "found", "in", "the", "nucleus", "(", "Fig", "S2c", ")", "." ] } ]
PMC9429973
Unfit patients include those < 75 years with one or more of the following comorbidities: Eastern Cooperative Oncology Group (ECOG) performance status of 2, clinically significant heart or lung comorbidities, contraindication to anthracycline therapy, or other comorbidity the investigator regards as incompatible with intensive remission induction chemotherapy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unfit", "patients", "include", "those", "<", "75", "years", "with", "one", "or", "more", "of", "the", "following", "comorbidities", ":", "Eastern", "Cooperative", "Oncology", "Group", "(", "ECOG", ")", "performance", "status", "of", "2", ",", "clinically", "significant", "heart", "or", "lung", "comorbidities", ",", "contraindication", "to", "anthracycline", "therapy", ",", "or", "other", "comorbidity", "the", "investigator", "regards", "as", "incompatible", "with", "intensive", "remission", "induction", "chemotherapy", "." ] } ]
PMC10047551
Several immune-cell-produced pro-inflammatory molecules, such as the type I and II interferons (IFNs), IFN-α/β, and IFN-γ, also induce cancer cell PD-L1 expression .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "immune-cell-produced", "pro-inflammatory", "molecules", ",", "such", "as", "the", "type", "I", "and", "II", "interferons", "(", "IFNs", ")", ",", "IFN-α/β", ",", "and", "IFN-γ", ",", "also", "induce", "cancer", "cell", "PD-L1", "expression", "." ] } ]
PMC11541409
For example, ERK inhibition can result in feedback reactivation of the MAPK pathway via RAS/CRAF .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", "ERK", "inhibition", "can", "result", "in", "feedback", "reactivation", "of", "the", "MAPK", "pathway", "via", "RAS/CRAF", "." ] } ]
PMC6133382
Twenty-four hours following transfection, the cells were distributed into 96-well tissue culture plates at a density of 0.5 cells/well. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twenty-four", "hours", "following", "transfection", ",", "the", "cells", "were", "distributed", "into", "96-well", "tissue", "culture", "plates", "at", "a", "density", "of", "0.5", "cells/well", ".", "(" ] } ]
PMC11537649
This novel regulatory network could contribute to the diagnosis and treatment of melanoma.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "novel", "regulatory", "network", "could", "contribute", "to", "the", "diagnosis", "and", "treatment", "of", "melanoma", "." ] } ]
PMC11674834
Retention times for 3,4-DMA and acetyl-3,4-DMA were 8.08 and 10.1, respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Retention", "times", "for", "3,4-DMA", "and", "acetyl-3,4-DMA", "were", "8.08", "and", "10.1", ",", "respectively", "." ] } ]
PMC11089031
Since ZNF692 is involved in both energy metabolism and immune regulation in ccRCC, we next explored single-cell RNA-seq data to analyze the expression pattern of ZNF692.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "ZNF692", "is", "involved", "in", "both", "energy", "metabolism", "and", "immune", "regulation", "in", "ccRCC", ",", "we", "next", "explored", "single-cell", "RNA-seq", "data", "to", "analyze", "the", "expression", "pattern", "of", "ZNF692", "." ] } ]