Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
Community
1
PMCID
string
Sentences
string
ner
list
PMC10957991
While the role of TRPV4 in breast cancer progression has been assessed by various studies, its role in the homeostasis of normal mammary epithelium has gained less focus.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "the", "role", "of", "TRPV4", "in", "breast", "cancer", "progression", "has", "been", "assessed", "by", "various", "studies", ",", "its", "role", "in", "the", "homeostasis", "of", "normal", "mammary", "epithelium", "has", "gained", "less", "focus", "." ] } ]
PMC11704135
Table 4DPPH radical scavenging activity (%) of the synthesized pyrimidine derivatives.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "4DPPH", "radical", "scavenging", "activity", "(", "%", ")", "of", "the", "synthesized", "pyrimidine", "derivatives", "." ] } ]
PMC11730311
Calcitonin gene-related peptide (CGRP) is a prominent target in migraine treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Calcitonin", "gene-related", "peptide", "(", "CGRP", ")", "is", "a", "prominent", "target", "in", "migraine", "treatment", "." ] } ]
PMC11806182
This differential expression analysis identified 15 miRNAs with significant expression changes (Fig. 1A).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "differential", "expression", "analysis", "identified", "15", "miRNAs", "with", "significant", "expression", "changes", "(", "Fig.", "1A", ")", "." ] } ]
PMC11772585
The relative ratio of EdU cells were calculated.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relative", "ratio", "of", "EdU", "cells", "were", "calculated", "." ] } ]
PMC10873328
The role of TGFBI in ovarian cancer chemoresistance. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "role", "of", "TGFBI", "in", "ovarian", "cancer", "chemoresistance", ".", "(" ] } ]
PMC11727062
Research has demonstrated that APS possesses anti-tumor capabilities.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Research", "has", "demonstrated", "that", "APS", "possesses", "anti-tumor", "capabilities", "." ] } ]
PMC11806106
For better comparability between the different agonist, we here only compare the first activation phase.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "better", "comparability", "between", "the", "different", "agonist", ",", "we", "here", "only", "compare", "the", "first", "activation", "phase", "." ] } ]
PMC9429973
Treatment is discontinued after 24 cycles, and patients will be monitored.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "is", "discontinued", "after", "24", "cycles", ",", "and", "patients", "will", "be", "monitored", "." ] } ]
PMC9429973
However, 71% (5/7) response rate was observed in the favourable ELN17 genetic risk group compared to 48% (32/67) in the non-favourable.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "71", "%", "(", "5/7", ")", "response", "rate", "was", "observed", "in", "the", "favourable", "ELN17", "genetic", "risk", "group", "compared", "to", "48", "%", "(", "32/67", ")", "in", "the", "non-favourable", "." ] } ]
PMC11451829
In the normal conjunctiva (Fig. 3A), no inflammation was observed, whereas grade 1, inflammation (Figs. 3B–D) included lymphocytes and plasmocytes at level 1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "normal", "conjunctiva", "(", "Fig.", "3A", ")", ",", "no", "inflammation", "was", "observed", ",", "whereas", "grade", "1", ",", "inflammation", "(", "Figs.", "3B", "–", "D", ")", "included", "lymphocytes", "and", "plasmocytes", "at", "level", "1", "." ] } ]
PMC11783017
Detection of MYC expression in different OS cells. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Detection", "of", "MYC", "expression", "in", "different", "OS", "cells", ".", "(" ] } ]
PMC11629461
A very short UVA (380 nm, 0.1 mWatt/cm) pulse of 1 s had no effect on the baseline calcium (Figure 5D) in SW579 cells, but longer pulses of 10, 30, 60, and 90 s all induced robust calcium spikes, dose dependently (Figure 5E–H).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "very", "short", "UVA", "(", "380", "nm", ",", "0.1", "mWatt/cm", ")", "pulse", "of", "1", "s", "had", "no", "effect", "on", "the", "baseline", "calcium", "(", "Figure", "5D", ")", "in", "SW579", "cells", ",", "but", "longer", "pulses", "of", "10", ",", "30", ",", "60", ",", "and", "90", "s", "all", "induced", "robust", "calcium", "spikes", ",", "dose", "dependently", "(", "Figure", "5E", "–", "H", ")", "." ] } ]
PMC11449273
Bottom: TCE from H1299-p53-WT cells was incubated with GST only beads and processed for pull down and immunoblot with GST and p53 antibodies. (
[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bottom", ":", "TCE", "from", "H1299-p53-WT", "cells", "was", "incubated", "with", "GST", "only", "beads", "and", "processed", "for", "pull", "down", "and", "immunoblot", "with", "GST", "and", "p53", "antibodies", ".", "(" ] } ]
PMC11507371
As a result, Nrf2 is released and translocates to the nucleus (Figure 1A), where it binds to the antioxidant-responsive element (ARE) present in the promoters of numerous cytoprotective genes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "result", ",", "Nrf2", "is", "released", "and", "translocates", "to", "the", "nucleus", "(", "Figure", "1A", ")", ",", "where", "it", "binds", "to", "the", "antioxidant-responsive", "element", "(", "ARE", ")", "present", "in", "the", "promoters", "of", "numerous", "cytoprotective", "genes", "." ] } ]
PMC6642070
p53 and β-enolase protein levels in gastrocnemius (GAS) and tibialis anterior (TA) muscles of mice treated with lovastatin for 30 days. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p53", "and", "β-enolase", "protein", "levels", "in", "gastrocnemius", "(", "GAS", ")", "and", "tibialis", "anterior", "(", "TA", ")", "muscles", "of", "mice", "treated", "with", "lovastatin", "for", "30", "days", ".", "(" ] } ]
PMC11243198
For gel electrophoresis, PCR products were run on agarose gels (2%) for 90 min at a constant 150 V. Gels were visualized with Syber Safe DNA stain and imaged using an iBright 1500 Imaging System (Invitrogen).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "gel", "electrophoresis", ",", "PCR", "products", "were", "run", "on", "agarose", "gels", "(", "2", "%", ")", "for", "90", "min", "at", "a", "constant", "150", "V.", "Gels", "were", "visualized", "with", "Syber", "Safe", "DNA", "stain", "and", "imaged", "using", "an", "iBright", "1500", "Imaging", "System", "(", "Invitrogen", ")", "." ] } ]
PMC11420784
UPEC were pretagged with magnetic nanoparticles before they were employed for 5637 cell infection, to isolate intracellular bacteria along with the vesicles using a magnet following a previously described method .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "UPEC", "were", "pretagged", "with", "magnetic", "nanoparticles", "before", "they", "were", "employed", "for", "5637", "cell", "infection", ",", "to", "isolate", "intracellular", "bacteria", "along", "with", "the", "vesicles", "using", "a", "magnet", "following", "a", "previously", "described", "method", "." ] } ]
PMC11552389
After loading 30 μg of total protein onto a 12% SDS-polyacrylamide gel, the protein was subjected to 80 V for 30 minutes and 120 V for 2 hours of electrophoresis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "loading", "30", "μg", "of", "total", "protein", "onto", "a", "12", "%", "SDS-polyacrylamide", "gel", ",", "the", "protein", "was", "subjected", "to", "80", "V", "for", "30", "minutes", "and", "120", "V", "for", "2", "hours", "of", "electrophoresis", "." ] } ]
PMC11437637
For each patient sample, label a BD Trucount tube with the sample identification number.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "each", "patient", "sample", ",", "label", "a", "BD", "Trucount", "tube", "with", "the", "sample", "identification", "number", "." ] } ]
PMC5941560
All remapped and submitted germline variants for GRCh37 were downloaded, and pathogenic variants were extracted from the files.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "remapped", "and", "submitted", "germline", "variants", "for", "GRCh37", "were", "downloaded", ",", "and", "pathogenic", "variants", "were", "extracted", "from", "the", "files", "." ] } ]
PMC7351993
The cell sorter is based on the principle of rapidly controlling the local flow at the sort point and isolating target cells from the central stream with the piezoelectrically actuated dual-membrane pumps.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "sorter", "is", "based", "on", "the", "principle", "of", "rapidly", "controlling", "the", "local", "flow", "at", "the", "sort", "point", "and", "isolating", "target", "cells", "from", "the", "central", "stream", "with", "the", "piezoelectrically", "actuated", "dual-membrane", "pumps", "." ] } ]
PMC11604768
Commercially available TREs, as well as negative control promoters were also included in the TRE-MPRA library.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Commercially", "available", "TREs", ",", "as", "well", "as", "negative", "control", "promoters", "were", "also", "included", "in", "the", "TRE-MPRA", "library", "." ] } ]
PMC11543853
Enterovirus virions may differ in the arrangement of packaged genomes and contain variable amounts of polyamines and inorganic cations that neutralize the repulsive interactions of virus RNA.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Enterovirus", "virions", "may", "differ", "in", "the", "arrangement", "of", "packaged", "genomes", "and", "contain", "variable", "amounts", "of", "polyamines", "and", "inorganic", "cations", "that", "neutralize", "the", "repulsive", "interactions", "of", "virus", "RNA", "." ] } ]
PMC11806818
Li et al. developed a visual and simple exosome colorimetric detection method based on molybdenum disulfide nanoflowers modified iron organic framework (MoS2-MIL-101(Fe)) hybrid nanozyme and CD63 aptamer.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Li", "et", "al.", "developed", "a", "visual", "and", "simple", "exosome", "colorimetric", "detection", "method", "based", "on", "molybdenum", "disulfide", "nanoflowers", "modified", "iron", "organic", "framework", "(", "MoS2-MIL-101(Fe", ")", ")", "hybrid", "nanozyme", "and", "CD63", "aptamer", "." ] } ]
PMC11705484
RNA samples from the cells were loaded by a 2‐fold serial dilution (1000 ng, 500 ng, 250 ng and 125 ng), and methylene blue staining served as the loading control. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "samples", "from", "the", "cells", "were", "loaded", "by", "a", "2‐fold", "serial", "dilution", "(", "1000", "ng", ",", "500", "ng", ",", "250", "ng", "and", "125", "ng", ")", ",", "and", "methylene", "blue", "staining", "served", "as", "the", "loading", "control", ".", "(" ] } ]
PMC11572213
Informed Consent: No informed consent is required.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Informed", "Consent", ":", "No", "informed", "consent", "is", "required", "." ] } ]
PMC8708099
The supernatant was discarded, and the RNA pellet was washed with 75% ethanol.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "supernatant", "was", "discarded", ",", "and", "the", "RNA", "pellet", "was", "washed", "with", "75", "%", "ethanol", "." ] } ]
PMC11489351
Alternatively, the Putney dataset may reflect both pH-dependent effects and compensatory transcriptional effects resulting not from altered pHi but from the genetic ablation, clonal selection, and adaptation required to generate the experimental cell lines used in that work.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Alternatively", ",", "the", "Putney", "dataset", "may", "reflect", "both", "pH-dependent", "effects", "and", "compensatory", "transcriptional", "effects", "resulting", "not", "from", "altered", "pHi", "but", "from", "the", "genetic", "ablation", ",", "clonal", "selection", ",", "and", "adaptation", "required", "to", "generate", "the", "experimental", "cell", "lines", "used", "in", "that", "work", "." ] } ]
PMC9429973
Peripheral blood mononuclear cells (PBMCs) were isolated with ficoll gradient and subjected to flow cytometry analysis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Peripheral", "blood", "mononuclear", "cells", "(", "PBMCs", ")", "were", "isolated", "with", "ficoll", "gradient", "and", "subjected", "to", "flow", "cytometry", "analysis", "." ] } ]
PMC9559528
The spirochete is transmitted through direct contact with active lesions during sexual activities or transplacentally from mother to fetus in pregnancy.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "spirochete", "is", "transmitted", "through", "direct", "contact", "with", "active", "lesions", "during", "sexual", "activities", "or", "transplacentally", "from", "mother", "to", "fetus", "in", "pregnancy", "." ] } ]
PMC11206251
Apoptosis inhibition is known to be one of the means by which cancer cells assure proliferation and survival.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Apoptosis", "inhibition", "is", "known", "to", "be", "one", "of", "the", "means", "by", "which", "cancer", "cells", "assure", "proliferation", "and", "survival", "." ] } ]
PMC11767817
Furthermore, 2a-B treatment increased p21 expression.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "2a-B", "treatment", "increased", "p21", "expression", "." ] } ]
PMC11718109
Scale bars, 10 μm.
[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "10", "μm", "." ] } ]
PMC10761571
Data are stated as mean ± SD.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "stated", "as", "mean", "±", "SD", "." ] } ]
PMC10978090
Thus, addition of PF4 to HIPA allowed detecting platelet-activating antibodies after the first TPE, while standard HIPA was already negative.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "addition", "of", "PF4", "to", "HIPA", "allowed", "detecting", "platelet-activating", "antibodies", "after", "the", "first", "TPE", ",", "while", "standard", "HIPA", "was", "already", "negative", "." ] } ]
PMC9429973
Both PD1+CD4+ and PD1+CD8+ T cells were higher in pts with a CLL-CI score of 1 vs 0 (p=.09 for both).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "PD1+CD4", "+", "and", "PD1+CD8", "+", "T", "cells", "were", "higher", "in", "pts", "with", "a", "CLL-CI", "score", "of", "1", "vs", "0", "(", "p=.09", "for", "both", ")", "." ] } ]
PMC11462673
Three separate experiments were executed.
[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "separate", "experiments", "were", "executed", "." ] } ]
PMC10421378
The samples for analysis were prepared by centrifugation and then suspended in a 1% PBS buffer in 1:200 dilution.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "samples", "for", "analysis", "were", "prepared", "by", "centrifugation", "and", "then", "suspended", "in", "a", "1", "%", "PBS", "buffer", "in", "1:200", "dilution", "." ] } ]
PMC9429973
Subjects that received a blood transfusion less than three months prior to measurements were excluded from the study.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subjects", "that", "received", "a", "blood", "transfusion", "less", "than", "three", "months", "prior", "to", "measurements", "were", "excluded", "from", "the", "study", "." ] } ]
PMC9693627
These data suggest that PTCD2 interacts with mitochondrial ribosome.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "suggest", "that", "PTCD2", "interacts", "with", "mitochondrial", "ribosome", "." ] } ]
PMC5854676
It was observed that the best model that fit all of the curves is the 2 order polynomial, as the sum of the square of errors is lower for this polynomial.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "observed", "that", "the", "best", "model", "that", "fit", "all", "of", "the", "curves", "is", "the", "2", "order", "polynomial", ",", "as", "the", "sum", "of", "the", "square", "of", "errors", "is", "lower", "for", "this", "polynomial", "." ] } ]
PMC9454178
6CDK7 inhibition leads to the suppression of RNA transcription in GIST cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "6CDK7", "inhibition", "leads", "to", "the", "suppression", "of", "RNA", "transcription", "in", "GIST", "cells", "." ] } ]
PMC11679892
A gradual decrease in cell viability was observed depending on the increasing concentrations of the extract: Cell viability decreased to 65% at a concentration of 100 µg/mL (p < 0.05); viability decreased to 55% at a concentration of 200 µg/mL (p < 0.05); viability decreased around 50% at 400 µg/mL; and viability decreased to 40% at a concentration of 800 µg/mL (p < 0.05).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "gradual", "decrease", "in", "cell", "viability", "was", "observed", "depending", "on", "the", "increasing", "concentrations", "of", "the", "extract", ":", "Cell", "viability", "decreased", "to", "65", "%", "at", "a", "concentration", "of", "100", "µg/mL", "(", "p", "<", "0.05", ")", ";", "viability", "decreased", "to", "55", "%", "at", "a", "concentration", "of", "200", "µg/mL", "(", "p", "<", "0.05", ")", ";", "viability", "decreased", "around", "50", "%", "at", "400", "µg/mL", ";", "and", "viability", "decreased", "to", "40", "%", "at", "a", "concentration", "of", "800", "µg/mL", "(", "p", "<", "0.05", ")", "." ] } ]
PMC11787381
These results appear to validate, for the first time, the amyloid hypothesis as a valuable target to fight AD in a disease-modifying manner and to pave the way for small amyloid-targeting molecules, orally administered, that are more clinically relevant, less responsible for ARIA events and less expensive.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "appear", "to", "validate", ",", "for", "the", "first", "time", ",", "the", "amyloid", "hypothesis", "as", "a", "valuable", "target", "to", "fight", "AD", "in", "a", "disease-modifying", "manner", "and", "to", "pave", "the", "way", "for", "small", "amyloid-targeting", "molecules", ",", "orally", "administered", ",", "that", "are", "more", "clinically", "relevant", ",", "less", "responsible", "for", "ARIA", "events", "and", "less", "expensive", "." ] } ]
PMC11507371
Therefore, 5 × 10 HaCaT and A431 cells were washed in PBS-/- and resuspended in 250 μL Diluent C, respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "5", "×", "10", "HaCaT", "and", "A431", "cells", "were", "washed", "in", "PBS-/-", "and", "resuspended", "in", "250", "μL", "Diluent", "C", ",", "respectively", "." ] } ]
PMC6222726
is a small tree or shrub, 4–6 m high, with a strong turpentine smell, and known as sak chakaj.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "is", "a", "small", "tree", "or", "shrub", ",", "4–6", "m", "high", ",", "with", "a", "strong", "turpentine", "smell", ",", "and", "known", "as", "sak", "chakaj", "." ] } ]
PMC10820104
Subsequently, the produced VLC fractions were preliminary tested for their cytotoxic potential against the human pancreatic PANC-1 cancer cell line at a concentration of 100 µg/mL. Remarkable cytotoxic activity was observed for fractions 4 and 5 after 72 h compared to 1 µM of the microtubule inhibitor paclitaxel, part of the first-line treatment regimen for PDAC patients (Figure 1).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "the", "produced", "VLC", "fractions", "were", "preliminary", "tested", "for", "their", "cytotoxic", "potential", "against", "the", "human", "pancreatic", "PANC-1", "cancer", "cell", "line", "at", "a", "concentration", "of", "100", "µg/mL.", "Remarkable", "cytotoxic", "activity", "was", "observed", "for", "fractions", "4", "and", "5", "after", "72", "h", "compared", "to", "1", "µM", "of", "the", "microtubule", "inhibitor", "paclitaxel", ",", "part", "of", "the", "first-line", "treatment", "regimen", "for", "PDAC", "patients", "(", "Figure", "1", ")", "." ] } ]
PMC11319300
We were able to show conservation across 18 different species, with a 273 bp sequence being evolutionarily conserved up to and including chickens (Figure 5).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "were", "able", "to", "show", "conservation", "across", "18", "different", "species", ",", "with", "a", "273", "bp", "sequence", "being", "evolutionarily", "conserved", "up", "to", "and", "including", "chickens", "(", "Figure", "5", ")", "." ] } ]
PMC11721587
To test this hypothesis, we treated Fu-depleted Cl8 cells stably expressing hemagglutinin (HA)–Fu at near endogenous level (fig. S1I) with Hh-conditioned medium for increasing amount of time.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "test", "this", "hypothesis", ",", "we", "treated", "Fu-depleted", "Cl8", "cells", "stably", "expressing", "hemagglutinin", "(HA)–Fu", "at", "near", "endogenous", "level", "(", "fig.", "S1I", ")", "with", "Hh-conditioned", "medium", "for", "increasing", "amount", "of", "time", "." ] } ]
PMC10565698
C. Analysis of CREB5 and TCF12 expression in liver cancer from the TIMER database.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C.", "Analysis", "of", "CREB5", "and", "TCF12", "expression", "in", "liver", "cancer", "from", "the", "TIMER", "database", "." ] } ]
PMC10362265
Orange and blue colors mark the left and right interfaces, respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Orange", "and", "blue", "colors", "mark", "the", "left", "and", "right", "interfaces", ",", "respectively", "." ] } ]
PMC8382973
The evaluation criteria were derived from the Biological evaluation of medical devices—Part 10: Tests for irritation and skin sensitization (GB/T16886.10-2017/ISO10993-10:2010, IDT) (40).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "evaluation", "criteria", "were", "derived", "from", "the", "Biological", "evaluation", "of", "medical", "devices", "—", "Part", "10", ":", "Tests", "for", "irritation", "and", "skin", "sensitization", "(", "GB/T16886.10", "-", "2017/ISO10993", "-", "10:2010", ",", "IDT", ")", "(", "40", ")", "." ] } ]
PMC8009078
3.421, 3.730 and 3.8832 Å when bound with A1, A2, A3, A4 and A5, respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3.421", ",", "3.730", "and", "3.8832", "Å", "when", "bound", "with", "A1", ",", "A2", ",", "A3", ",", "A4", "and", "A5", ",", "respectively", "." ] } ]
PMC2118063
Because IRF8 positively regulates its own expression (10), this allowed us to monitor human IRF8 expression from the endogenous locus using species-specific primers.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Because", "IRF8", "positively", "regulates", "its", "own", "expression", "(", "10", ")", ",", "this", "allowed", "us", "to", "monitor", "human", "IRF8", "expression", "from", "the", "endogenous", "locus", "using", "species-specific", "primers", "." ] } ]
PMC10440586
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "authors", "declare", "that", "they", "have", "no", "known", "competing", "financial", "interests", "or", "personal", "relationships", "that", "could", "have", "appeared", "to", "influence", "the", "work", "reported", "in", "this", "paper", "." ] } ]
PMC9429973
Median follow-up was 38 months; FLT3mut was present in 227 cases (25%) and constitute the focus of this study.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "follow-up", "was", "38", "months", ";", "FLT3mut", "was", "present", "in", "227", "cases", "(", "25", "%", ")", "and", "constitute", "the", "focus", "of", "this", "study", "." ] } ]
PMC11252553
The percentages of apoptotic lymphocytes are depicted as a histogram with standard deviations at three doses of 4, 8, & 12 Gy for four sample groups: non-irradiated & untreated, untreated with irradiation (negative control), cysteine-treated with irradiation (100 µg.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "percentages", "of", "apoptotic", "lymphocytes", "are", "depicted", "as", "a", "histogram", "with", "standard", "deviations", "at", "three", "doses", "of", "4", ",", "8", ",", "&", "12", "Gy", "for", "four", "sample", "groups", ":", "non-irradiated", "&", "untreated", ",", "untreated", "with", "irradiation", "(", "negative", "control", ")", ",", "cysteine-treated", "with", "irradiation", "(", "100", "µg", "." ] } ]
PMC11687663
From phytoconstituents side, Quercetin (B12) and Schaftoside (B7) showed best binding affinity of -8.8 and -8.1 kcal/mol, respectively (Table 3).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", "phytoconstituents", "side", ",", "Quercetin", "(", "B12", ")", "and", "Schaftoside", "(", "B7", ")", "showed", "best", "binding", "affinity", "of", "-8.8", "and", "-8.1", "kcal/mol", ",", "respectively", "(", "Table", "3", ")", "." ] } ]
PMC9429973
M. Paul, L. Abraham, C. M. Jeswin, A. Ajithkumar, C. O. D’souza, M. Abraham Clinical Haematology & Haemato-oncology; Clinical Pathology, Rajagiri Hospital, Alwaye, India Background: Acute myeloid leukaemia (AML) is an aggressive haematological malignancy and is more common in the older adults.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "M.", "Paul", ",", "L.", "Abraham", ",", "C.", "M.", "Jeswin", ",", "A.", "Ajithkumar", ",", "C.", "O.", "D’souza", ",", "M.", "Abraham", "Clinical", "Haematology", "&", "Haemato-oncology", ";", "Clinical", "Pathology", ",", "Rajagiri", "Hospital", ",", "Alwaye", ",", "India", "Background", ":", "Acute", "myeloid", "leukaemia", "(", "AML", ")", "is", "an", "aggressive", "haematological", "malignancy", "and", "is", "more", "common", "in", "the", "older", "adults", "." ] } ]
PMC5673955
Induction of Jurkat cells’ and normal CD4 T cells’ killing during cultivation with RrA. Flow cytometry results of (A) Jurkat cells and (B) CD4 T cells incubated with RrA and labeled with Annexin V‐FITC and PI.
[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Induction", "of", "Jurkat", "cells", "’", "and", "normal", "CD4", "T", "cells", "’", "killing", "during", "cultivation", "with", "RrA.", "Flow", "cytometry", "results", "of", "(", "A", ")", "Jurkat", "cells", "and", "(", "B", ")", "CD4", "T", "cells", "incubated", "with", "RrA", "and", "labeled", "with", "Annexin", "V‐FITC", "and", "PI", "." ] } ]
PMC11705067
An increasing number of PCD types, such as apoptosis, necroptosis, autophagy, ferroptosis and pyroptosis, have been implicated in the pathological and physiological processes of various diseases, especially tumors7, 8.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "increasing", "number", "of", "PCD", "types", ",", "such", "as", "apoptosis", ",", "necroptosis", ",", "autophagy", ",", "ferroptosis", "and", "pyroptosis", ",", "have", "been", "implicated", "in", "the", "pathological", "and", "physiological", "processes", "of", "various", "diseases", ",", "especially", "tumors7", ",", "8", "." ] } ]
PMC10748106
The increased polarity of Geniposide due to the incorporation of the glucose in C1, and the distribution of this molecular charge, impact on the electronic distribution, and finally on the inactivity of the iridoid, unlike Genipin.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "increased", "polarity", "of", "Geniposide", "due", "to", "the", "incorporation", "of", "the", "glucose", "in", "C1", ",", "and", "the", "distribution", "of", "this", "molecular", "charge", ",", "impact", "on", "the", "electronic", "distribution", ",", "and", "finally", "on", "the", "inactivity", "of", "the", "iridoid", ",", "unlike", "Genipin", "." ] } ]
PMC11352877
This increase in the level of HIF-1α is a measure of invasiveness and metastasis (Figure 5A—12Z, A2780, RL-95-2, and SK-UT-1) , which is mediated through the orientation of energy metabolism almost exclusively by the process of glycolysis and the increase in angiogenic factors; this leads to the prompt formation of a vascular network and thus to a rapid exchange of metabolites between pathological cells .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "increase", "in", "the", "level", "of", "HIF-1α", "is", "a", "measure", "of", "invasiveness", "and", "metastasis", "(", "Figure", "5A—12Z", ",", "A2780", ",", "RL-95", "-", "2", ",", "and", "SK-UT-1", ")", ",", "which", "is", "mediated", "through", "the", "orientation", "of", "energy", "metabolism", "almost", "exclusively", "by", "the", "process", "of", "glycolysis", "and", "the", "increase", "in", "angiogenic", "factors", ";", "this", "leads", "to", "the", "prompt", "formation", "of", "a", "vascular", "network", "and", "thus", "to", "a", "rapid", "exchange", "of", "metabolites", "between", "pathological", "cells", "." ] } ]
PMC9429973
J. Ussmann, S. Hell, B. Schetschorke, G. Friedrich, C. Pfrepper, S. Schwind, M. Jentzsch, V. Vucinic, M. Herling, U. Platzbecker, G.-N. Franke Medical Department I, Hematology, cellular therapies and Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany Background: Allogeneic hematopoietic stem cell transplantation (HSCT) is still the only potentially curative treatment for patients (pts) with high-risk acute myeloid leukemia (AML).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "J.", "Ussmann", ",", "S.", "Hell", ",", "B.", "Schetschorke", ",", "G.", "Friedrich", ",", "C.", "Pfrepper", ",", "S.", "Schwind", ",", "M.", "Jentzsch", ",", "V.", "Vucinic", ",", "M.", "Herling", ",", "U.", "Platzbecker", ",", "G.-N.", "Franke", "Medical", "Department", "I", ",", "Hematology", ",", "cellular", "therapies", "and", "Hemostaseology", ",", "University", "of", "Leipzig", "Medical", "Center", ",", "Leipzig", ",", "Germany", "Background", ":", "Allogeneic", "hematopoietic", "stem", "cell", "transplantation", "(", "HSCT", ")", "is", "still", "the", "only", "potentially", "curative", "treatment", "for", "patients", "(", "pts", ")", "with", "high-risk", "acute", "myeloid", "leukemia", "(", "AML", ")", "." ] } ]
PMC11711347
The U.S. Food and Drug Administration (FDA) authorized the use of cisplatin in 1978, following research dating back to 1965 that demonstrated its efficacy against a variety of cancer cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "U.S.", "Food", "and", "Drug", "Administration", "(", "FDA", ")", "authorized", "the", "use", "of", "cisplatin", "in", "1978", ",", "following", "research", "dating", "back", "to", "1965", "that", "demonstrated", "its", "efficacy", "against", "a", "variety", "of", "cancer", "cells", "." ] } ]
PMC11525028
However, the IC50 of Remodelin (143B IC50 = 50.17 μM, HOS IC50 = 45.61 μM) was higher than that of paliperidone and AG-401 (Figure S5D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "IC50", "of", "Remodelin", "(", "143B", "IC50", "=", "50.17", "μM", ",", "HOS", "IC50", "=", "45.61", "μM", ")", "was", "higher", "than", "that", "of", "paliperidone", "and", "AG-401", "(", "Figure", "S5D", ")", "." ] } ]
PMC11697065
Here, significant correlation was observed for LC and HC transcript and GCN for monoclonal antibodies, but not for bispecific antibodies (Supplemental Figure 6A-D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "significant", "correlation", "was", "observed", "for", "LC", "and", "HC", "transcript", "and", "GCN", "for", "monoclonal", "antibodies", ",", "but", "not", "for", "bispecific", "antibodies", "(", "Supplemental", "Figure", "6A-D", ")", "." ] } ]
PMC11767793
The Au-PEG-COOH@C1 was somewhat more stable in DMEM compared with the Au-PEI@C1 and Au-PEI@C2, but its SPR absorbance also decreased, as was observed with the Au-PEG-COOH@NIST.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Au-PEG-COOH@C1", "was", "somewhat", "more", "stable", "in", "DMEM", "compared", "with", "the", "Au-PEI@C1", "and", "Au-PEI@C2", ",", "but", "its", "SPR", "absorbance", "also", "decreased", ",", "as", "was", "observed", "with", "the", "Au-PEG-COOH@NIST", "." ] } ]
PMC11633763
From the day of injection until the conclusion of the fifth week, measure the tumour's size every 5 days.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", "the", "day", "of", "injection", "until", "the", "conclusion", "of", "the", "fifth", "week", ",", "measure", "the", "tumour", "'s", "size", "every", "5", "days", "." ] } ]
PMC11463018
Compound 16a-c, 16j and 19 with preferred enzymatic inhibitory activity were selected to test their effects on tumour cell viability.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compound", "16a-c", ",", "16j", "and", "19", "with", "preferred", "enzymatic", "inhibitory", "activity", "were", "selected", "to", "test", "their", "effects", "on", "tumour", "cell", "viability", "." ] } ]
PMC10713411
Furthermore, the subgroups of various clinical features (age, sex, clinical stage and pathological grade) were selected and the prognosis of patients in these two groups was calculated in various subgroups, illustrating that patients from the high-PRPCDGs-risk group confronted more unfavorable outcomes than those in the other group among most subgroups (Supplementary Figure 3), which mirrored that the PRPCDGs risk signature had a robust predictive efficacy in patients’ prognosis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "subgroups", "of", "various", "clinical", "features", "(", "age", ",", "sex", ",", "clinical", "stage", "and", "pathological", "grade", ")", "were", "selected", "and", "the", "prognosis", "of", "patients", "in", "these", "two", "groups", "was", "calculated", "in", "various", "subgroups", ",", "illustrating", "that", "patients", "from", "the", "high-PRPCDGs-risk", "group", "confronted", "more", "unfavorable", "outcomes", "than", "those", "in", "the", "other", "group", "among", "most", "subgroups", "(", "Supplementary", "Figure", "3", ")", ",", "which", "mirrored", "that", "the", "PRPCDGs", "risk", "signature", "had", "a", "robust", "predictive", "efficacy", "in", "patients", "’", "prognosis", "." ] } ]
PMC11721587
Immunostaining of Ci and HA-Fu proteins in Fu-depleted Cl8 cells stably expressing the indicated RNAi-insensitive HA-Fu constructs and treated with Hh-conditioned or control medium for 16 hours. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunostaining", "of", "Ci", "and", "HA-Fu", "proteins", "in", "Fu-depleted", "Cl8", "cells", "stably", "expressing", "the", "indicated", "RNAi-insensitive", "HA-Fu", "constructs", "and", "treated", "with", "Hh-conditioned", "or", "control", "medium", "for", "16", "hours", ".", "(" ] } ]
PMC11127909
143BR-shEFHD1 cells had a dramatic reduction in c-Myc expression compared with 143BR-shV cells.
[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "143BR-shEFHD1", "cells", "had", "a", "dramatic", "reduction", "in", "c-Myc", "expression", "compared", "with", "143BR-shV", "cells", "." ] } ]
PMC8584319
The anti-puromycin and anti-glyceraldehyde 3-phosphate dehydrogenase (GAPDH) antibodies were purchased from Millipore (Burlington, MA, USA) and Santa Cruz Biotechnology (Dallas, TX, USA), respectively.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "anti-puromycin", "and", "anti-glyceraldehyde", "3-phosphate", "dehydrogenase", "(", "GAPDH", ")", "antibodies", "were", "purchased", "from", "Millipore", "(", "Burlington", ",", "MA", ",", "USA", ")", "and", "Santa", "Cruz", "Biotechnology", "(", "Dallas", ",", "TX", ",", "USA", ")", ",", "respectively", "." ] } ]
PMC3734024
Using this culture system, we investigated the effects of adding recombinant murine IL-5 to cultures of CD19 B cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "this", "culture", "system", ",", "we", "investigated", "the", "effects", "of", "adding", "recombinant", "murine", "IL-5", "to", "cultures", "of", "CD19", "B", "cells", "." ] } ]
PMC6442998
In the imatinib-sensitive GIST882 cell line, the PDE3 inhibitor cilostazol (Pletal™), already in clinical use for cardiovascular indications, halved cell viability and, most interestingly, can do so in synergy with imatinib .
[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "imatinib-sensitive", "GIST882", "cell", "line", ",", "the", "PDE3", "inhibitor", "cilostazol", "(", "Pletal", "™", ")", ",", "already", "in", "clinical", "use", "for", "cardiovascular", "indications", ",", "halved", "cell", "viability", "and", ",", "most", "interestingly", ",", "can", "do", "so", "in", "synergy", "with", "imatinib", "." ] } ]
PMC10850553
Dissected specimen was fixed in formalin solution and embedded in paraffin.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Dissected", "specimen", "was", "fixed", "in", "formalin", "solution", "and", "embedded", "in", "paraffin", "." ] } ]
PMC9812014
Alkaloids fusaindoterpene-B alkaloid, JBIR-03, and 1,2-bis(1H-indol-3-yl)ethane-1,2-dione—all of which are indoloterpene alkaloids—showed strong repressive activity in the plaque reduction assay with EC50 concentrations of 7.5, 4.2, and 5.0 μM, correspondingly against the Zika virus .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Alkaloids", "fusaindoterpene-B", "alkaloid", ",", "JBIR-03", ",", "and", "1,2-bis(1H-indol-3-yl)ethane-1,2-dione", "—", "all", "of", "which", "are", "indoloterpene", "alkaloids", "—", "showed", "strong", "repressive", "activity", "in", "the", "plaque", "reduction", "assay", "with", "EC50", "concentrations", "of", "7.5", ",", "4.2", ",", "and", "5.0", "μM", ",", "correspondingly", "against", "the", "Zika", "virus", "." ] } ]
PMC9429973
As expected, the BTKi group was enriched for pts with MYD88 mutation (n=29, 94%) vs 49% (n=30) in the no BTKi group, p<0.001.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "expected", ",", "the", "BTKi", "group", "was", "enriched", "for", "pts", "with", "MYD88", "mutation", "(", "n=29", ",", "94", "%", ")", "vs", "49", "%", "(", "n=30", ")", "in", "the", "no", "BTKi", "group", ",", "p<0.001", "." ] } ]
PMC6222635
The graph of relative expression of all tested genes was shown in Figure 10.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "graph", "of", "relative", "expression", "of", "all", "tested", "genes", "was", "shown", "in", "Figure", "10", "." ] } ]
PMC10728200
Drug inhibition assay was performed by seeding and incubating 5 × 10 GIST-T1 or GIST-882 cells at 37 °C overnight.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Drug", "inhibition", "assay", "was", "performed", "by", "seeding", "and", "incubating", "5", "×", "10", "GIST-T1", "or", "GIST-882", "cells", "at", "37", "°", "C", "overnight", "." ] } ]
PMC11803918
As shown in Figure 6J,K, a significantly higher level of MART-1-specific CD4 and CD8 T-cell response in the photoirradiated hybrid group was observed.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "shown", "in", "Figure", "6J", ",", "K", ",", "a", "significantly", "higher", "level", "of", "MART-1-specific", "CD4", "and", "CD8", "T-cell", "response", "in", "the", "photoirradiated", "hybrid", "group", "was", "observed", "." ] } ]
PMC9429973
The number of CD34 positive cells tended to decrease after more than 4 courses of VRD induction therapies.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "number", "of", "CD34", "positive", "cells", "tended", "to", "decrease", "after", "more", "than", "4", "courses", "of", "VRD", "induction", "therapies", "." ] } ]
PMC11754094
Let NT be the total number of reads passing the cut site (±13 base pairs), including large deletions.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Let", "NT", "be", "the", "total", "number", "of", "reads", "passing", "the", "cut", "site", "(", "±13", "base", "pairs", ")", ",", "including", "large", "deletions", "." ] } ]
PMC11001582
However, the most relevant effects of DPRs in the endogenous context are not known.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "most", "relevant", "effects", "of", "DPRs", "in", "the", "endogenous", "context", "are", "not", "known", "." ] } ]
PMC11264242
Our ChIP-seq data not only confirmed the occupancy of SS18-SSX2 at known target gene regions (Supplementary Figure S3), but also uncovered new candidate SS18-SSX2 target genes, such as MYC, CDX2 and PDGFRA (Figure 1B), known to be involved in the control of cell proliferation and transformation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "ChIP-seq", "data", "not", "only", "confirmed", "the", "occupancy", "of", "SS18-SSX2", "at", "known", "target", "gene", "regions", "(", "Supplementary", "Figure", "S3", ")", ",", "but", "also", "uncovered", "new", "candidate", "SS18-SSX2", "target", "genes", ",", "such", "as", "MYC", ",", "CDX2", "and", "PDGFRA", "(", "Figure", "1B", ")", ",", "known", "to", "be", "involved", "in", "the", "control", "of", "cell", "proliferation", "and", "transformation", "." ] } ]
PMC9429973
Negative attitudes towards the COVID-19 vaccine are worrisome for at-risk patient groups.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Negative", "attitudes", "towards", "the", "COVID-19", "vaccine", "are", "worrisome", "for", "at-risk", "patient", "groups", "." ] } ]
PMC9454178
The CDK4, CDK7 and CDK9 mRNA levels were significantly higher than those of other CDKs, and further, we found that the CDK7 mRNA level was significantly elevated in high-risk GISTs, while there was no significant difference in CDK4 and CDK9.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CDK4", ",", "CDK7", "and", "CDK9", "mRNA", "levels", "were", "significantly", "higher", "than", "those", "of", "other", "CDKs", ",", "and", "further", ",", "we", "found", "that", "the", "CDK7", "mRNA", "level", "was", "significantly", "elevated", "in", "high-risk", "GISTs", ",", "while", "there", "was", "no", "significant", "difference", "in", "CDK4", "and", "CDK9", "." ] } ]
PMC7334607
In collateral resistance, the fitness landscapes of the organism (bacteria or cancer) in the presence of each drug would show “positive correlation” (Nichol et al., 2019).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "collateral", "resistance", ",", "the", "fitness", "landscapes", "of", "the", "organism", "(", "bacteria", "or", "cancer", ")", "in", "the", "presence", "of", "each", "drug", "would", "show", "“", "positive", "correlation", "”", "(", "Nichol", "et", "al.", ",", "2019", ")", "." ] } ]
PMC5173112
As a result, siRNA-mediated depletion of USP21 inhibits cell proliferation, invasion ability and decreases the CSCs percentage of RCC cell lines.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "result", ",", "siRNA-mediated", "depletion", "of", "USP21", "inhibits", "cell", "proliferation", ",", "invasion", "ability", "and", "decreases", "the", "CSCs", "percentage", "of", "RCC", "cell", "lines", "." ] } ]
PMC11719944
A descriptive and comparative analysis of the clinical characteristics of the groups was performed.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "descriptive", "and", "comparative", "analysis", "of", "the", "clinical", "characteristics", "of", "the", "groups", "was", "performed", "." ] } ]
PMC10667689
Moreover, the elevation of extracellular free fatty acids, glucose consumption, lactate release, the concentration of cellular glutathione (GSH) and cell proliferation were significantly higher in the presence of Gal-9 compared to the PMA and control groups in both cell lines (p < 0.05).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "elevation", "of", "extracellular", "free", "fatty", "acids", ",", "glucose", "consumption", ",", "lactate", "release", ",", "the", "concentration", "of", "cellular", "glutathione", "(", "GSH", ")", "and", "cell", "proliferation", "were", "significantly", "higher", "in", "the", "presence", "of", "Gal-9", "compared", "to", "the", "PMA", "and", "control", "groups", "in", "both", "cell", "lines", "(", "p", "<", "0.05", ")", "." ] } ]
PMC11768927
These factors collectively contribute to the reduced efficacy of VSV-based oncolytic virotherapy in certain cancer types.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "factors", "collectively", "contribute", "to", "the", "reduced", "efficacy", "of", "VSV-based", "oncolytic", "virotherapy", "in", "certain", "cancer", "types", "." ] } ]
PMC11499381
This approach was chosen based on previous literature , and to provide proof-of-concept for the N-terminal fusion orientation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "approach", "was", "chosen", "based", "on", "previous", "literature", ",", "and", "to", "provide", "proof-of-concept", "for", "the", "N-terminal", "fusion", "orientation", "." ] } ]
PMC11089031
To explore the expression profile of ZNF692 in ccRCC, we queried The University of Alabama at Birmingham Cancer data analysis Portal (UALCAN, http://ualcan.path.uab.edu/analysis.html) to assess the expression levels of ZNF692 in ccRCC in a dataset from The Cancer Genome Atlas (TCGA) using normal kidney tissue as a control .The input gene symbol "ZNF692" was utilized to query its expression within the TCGA dataset "Kidney renal clear cell carcinoma (KIRC)".
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "explore", "the", "expression", "profile", "of", "ZNF692", "in", "ccRCC", ",", "we", "queried", "The", "University", "of", "Alabama", "at", "Birmingham", "Cancer", "data", "analysis", "Portal", "(", "UALCAN", ",", "http://ualcan.path.uab.edu/analysis.html", ")", "to", "assess", "the", "expression", "levels", "of", "ZNF692", "in", "ccRCC", "in", "a", "dataset", "from", "The", "Cancer", "Genome", "Atlas", "(", "TCGA", ")", "using", "normal", "kidney", "tissue", "as", "a", "control", ".The", "input", "gene", "symbol", "\"", "ZNF692", "\"", "was", "utilized", "to", "query", "its", "expression", "within", "the", "TCGA", "dataset", "\"", "Kidney", "renal", "clear", "cell", "carcinoma", "(", "KIRC", ")", "\"", "." ] } ]
PMC11623887
B19V activates a DNA damage response (DDR) through critical kinases such as ATR, ATM, and DNA-PKcs in the infected cells that are facilitated by viral DNA replication mainly through NS1.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B19V", "activates", "a", "DNA", "damage", "response", "(", "DDR", ")", "through", "critical", "kinases", "such", "as", "ATR", ",", "ATM", ",", "and", "DNA-PKcs", "in", "the", "infected", "cells", "that", "are", "facilitated", "by", "viral", "DNA", "replication", "mainly", "through", "NS1", "." ] } ]
PMC9429973
Methods: A cross-sectional hospital-based study was included 200 Sudanese children (mean age 8.43 ± 3.80 years; 53% boys; 47% girls).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "A", "cross-sectional", "hospital-based", "study", "was", "included", "200", "Sudanese", "children", "(", "mean", "age", "8.43", "±", "3.80", "years", ";", "53", "%", "boys", ";", "47", "%", "girls", ")", "." ] } ]
PMC11335267
The region of interest corresponding to the hypothalamic area used for quantification is indicated with a blue line. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "region", "of", "interest", "corresponding", "to", "the", "hypothalamic", "area", "used", "for", "quantification", "is", "indicated", "with", "a", "blue", "line", ".", "(" ] } ]
PMC8193046
Workflow of the herein presented virtual screening approach.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Workflow", "of", "the", "herein", "presented", "virtual", "screening", "approach", "." ] } ]