Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC11680578
p < 0.05, **p < 0.01 and ***< 0.001 as compared to that of the control.
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PMC11509224
The dolabellane diterpenoid, named clavirolide H (111, Figure 11), was isolated from the Xisha sponge Fascaplysinopsis reticulata .
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PMC11680982
For 400 nM CDK4/6i + 100 nM ET: HER2-low vs. HER2-0, P = 0.0001.
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PMC9872547
Statistical analyses were performed by GraphPad Prism 7 software.
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PMC11704135
The more potential for donating electrons a compound has the greater radical scavenging activity it possesses.
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PMC11592837
Autofocusing based on DAPI staining identified cell nuclei using 10 images in the z dimension at a distance of 1 mm each throughout the nucleus.
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PMC7189327
A growing number of studies have demonstrated that gene expression profiling could effectively screen molecular makers and predict pathogenesis for tumorigenesis in the last decades, thereby offering novel therapeutic strategies for cancer treatment .
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PMC11001582
Graph, mean ± s.e.m.,
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PMC11590870
Due to the above, a small amount or none reaches the cell’s interior .
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PMC11768281
Current strategies for treating infectious diseases, particularly malaria, have increasingly focused on harnessing the human immune system.
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PMC11711345
Synthesis of the sodium cuminate.
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PMC11676674
The antigenotoxic hormetic concentration-dependent effect was also observed in other plant extracts, including Dendrobium speciosum stem extract, where lower concentrations of the stem extract showed antigenotoxic effects against 4NQO-induced NDA damage in HEPG2 cells when determined using the comet assay .
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PMC11400680
Cells counts and (B) nuclei counts.
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PMC11574271
At day 32, all mice were euthanized accordingly and tumor xenografts were harvested from animals to be examined for any metastatic lesions in tissue and organs.
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PMC11509224
Compounds 227 and 228 showed cytotoxicity against NBT-T2 cells, with IC50 values of 5.6 and 12 µg/mL, respectively.
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PMC11543853
Major group rhinoviruses and rhinoviruses, which have adapted to use heparan-sulfate as a receptor were indicated to induce endosome disruption and release their genomes both into the endosomes and cytoplasm.
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PMC11615828
Compared to control cells, immobilization of Rab11a‐ and Rab11b‐positive recycling endosomes resulted in significantly more transferrin accumulating inside the cells (Figure S17c,d, Supporting Information).
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PMC11515150
ELISA data showing the release of IFN-γ and Granzyme B by NT-NK and 12 C CAR-NK cells after co-incubated with different target cells overnight (n = 3; ****p < 0.0001).
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PMC10958426
UMAP visualization of cancer cells from both scWGS and scRNA data in patient CRC#1, Cells colored by tumor subclone inferred by CNVs and shaped by datasets. (
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PMC11486946
As a result, 18 compounds were obtained, but one of them, auranofin, was excluded from further analysis due to its cytotoxicity (cell death) during the treatment.
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PMC11471157
Even on the 7th day of culture, DFP remained present, with HaCaT cells adhering to and proliferating around it (Fig. 3C).
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PMC7039683
In addition, average expression of such genes was higher in GFP-positive versus GFP-negative cells in our RNA-seq profiles of these two cell types (p<1.46e-05, Mann-Whitney-Wilcoxon Test).
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PMC7351993
b SRS images of PS and PMMA particles (representative of n = 9786 and n = 4063, respectively) at the four wavenumbers and decomposed images of the particles.
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PMC10170482
The liver ECM in healthy tissues and cancer pathology is more complex and is composed of collagen types I, III, IV, and V; fibronectin; elastin; and many other proteins.
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PMC9429973
CD3 and CD5 expression, as well as that of PD-L1, was evaluated to identify some characteristics of the tumor microenvironment (TME).
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PMC11064533
Similar to our results of the adhesion assay, deletion of the pil locus did not affect bacterial auto-aggregation or adhesion to HEp-2 cells in strain 12-05829 and O113:H2 98NK2 strain (57).
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PMC9429973
Aims: We aimed to study the consequences of manipulating the AHR pathway in vivo in a murine leukaemia model.
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PMC11786767
Immunostaining and immunoblotting revealed that Ki67-miR significantly reduced Ki-67 protein levels in COS-7 cells relative to the control construct Ctrl-miR (Fig. 5A–C).
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PMC9250505
Unfortunately, almost all patients will also eventually acquire resistance to PARPi treatment.
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PMC11720107
Garlic contains various minerals, including vitamins C and B6, as well as numerous biologically active substances .
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PMC10443665
The manuscript was written by B. Samii under the supervision of A. Jafarian, M. Rabbani, B. Zolfaghari, S. Rahgozar.
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PMC10577955
Lung cancer is ranked as the second principal cause of cancer death worldwide .
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PMC10999934
It suggested that FBXO2 may affect tumor stemness in HGSOC, which is worthy of further verification in subsequent studies.
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PMC10222971
Considering this background, the work described herein reports the evaluation of the cytotoxicity of different acyl and alkyl derivatives from juglone and lawsone that showed the best activity results from a etiolated wheat coleoptile bioassay.
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PMC10170482
Cells were seeded into collagen scaffolds (CSs), cultivated for 7 days, and labeled before laser irradiation.
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PMC8873393
Where there are several CDS isoforms in a gene, they are all counted.
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PMC11519567
C Histogram with the number of condensates in (B).
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PMC11046454
In contrast, the DPBS and Lib-CAR-T groups showed minimal CD3 T cell infiltration.
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PMC11286266
Sorted cells were either collected in fresh media as a bulk of cells or individually sorted into 96-well plates and then expanded.
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PMC10094992
As is well known, neutrophils, after their mobilization from the bone marrow, are recruited to the tumour site by the action of neutrophil-attracting chemokines, mainly IL-8, that can be produced not only by other immune cells but also directly by tumour cells and cancer associated fibroblasts .
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PMC9587866
Virtual Screening Results The interaction analysis showed that two natural compounds Sorbifolin and 1,7-Dihydroxy-3-methylanthracene-9.10-dione made hydrogen bonds with the active amino acids of EYA3 (Table 2) (Figure 1).
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PMC11658074
The microfat graft was prepared according to a previously reported procedure .
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PMC11534035
This result suggests that in VC, PAI1 is in part responsible for the rapid proliferation of the tumor cells.
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PMC11604768
Heatmaps were generated using Morpheus.
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PMC11258145
However, there are no reports in which model studies have been compared with native systems, where reactions resulting from the amount of membrane components and the number of biochemical processes occurring simultaneously in cells can influence the effects of curcumin observed in an isolated model system.
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PMC11365427
Our research has provided compelling evidence that phenylalanine deprivation can inhibit MM.
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PMC6461034
Repeat the 1 ml IP buffer wash three times.
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PMC9429973
In vitro treatment with the inhibitors efficiently reduced cell viability of CLL cell lines and primary cells, as for MCL and DLBCL cell lines, at low nanomolar dose while no effect was observed on MM cell lines (B).
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PMC11201989
In addition, double knockdown of PD-L1 and BBS5 did not affect the percentage of PC-2-positive cilia compared to knockdown of PD-L1 alone but increased the percentage of PC-2-positive cilia compared to knockdown of BBS5 alone (Figure 5D,E).
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PMC9926039
To measure the level of TLR4 and GAPDH mRNA expression, an RT-PCR system was implemented.
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PMC11412721
Furthermore, several lines of evidence suggest that Ackr4 might act as a tumor suppressor of Myc-driven B-cell lymphomas.
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PMC11471157
For the culture without DFP, the cell culture was conducted in the same manner, excluding the addition of DFP.
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PMC9429973
63% (36/57) had undergone at least to a single ASCT.
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PMC10212663
AUC, area under curve; LUAD, lung adenocarcinoma; OS, overall survival.
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PMC11731614
The commercially available CD63-GFP fl/fl mouse line (Jackson Laboratory Strain#:036865) was crossed with K14-Cre mice to generate the EV-reporter K14-CD63-GFP mouse line.
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PMC9429973
Results: 90 pts were assessed: median age 34.5 yrs (range 18–71); 50.0% female; median mitapivat exposure 20 mos (range 12.2–64.9); concomitant bisphosphonate medication, 8 pts (8.9%); prior medical history of fracture, 8 pts (8.9%); fractures/joint injuries during study period, 6 pts (6.7%).
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PMC11352746
This attrition rate associated with CNS drug discovery as compared to non-CNS drug discovery can be attributed to the challenges associated with the drug discovery process, as several CNS drugs have been discontinued in clinical trials due to their inefficacy .
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PMC9884169
Besides, siMCT4 could also induce inhibition of autophagy in 5637 cells and enhance tumor cell apoptosis reduced by autophagy inhibitor CQ (Selleck).
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PMC11519567
Separate the beads with a magnet until the supernatant is clear.
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PMC10936243
Even if they defaecate, we will just clean it, unless there are babies” [D073]. “
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PMC11464609
Taxonomic classification of these samples demonstrated a considerably lower background compared to conventional metagenomics (mean: 53% vs. 99%, p < 0.001, t test) with a higher proportion of viral reads per million (median: 241509 vs. 344 rpm, p = 0.001, t test, Supplementary Table 1, Fig. 1b) resulting in a median 1129-fold enrichment of viral sequences.
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PMC3734024
While B cell-mediated immunosuppression by secretion of the anti-inflammatory cytokine interleukin-10 (IL-10) has received much recent attention, there are several reports of suppressive effects of B cells independent of IL-10, including in mouse models of type 1 diabetes and multiple sclerosis , –. Additionally, it was recently shown that selective deletion of IL-10 in B cells did not affect disease parameters in a mouse model of lupus, suggesting that the in vivo effects of endogenous regulation by IL-10-producing B cells may be more subtle than previously thought .
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PMC11075223
The anti-inflammatory effect of cimiracemate A was performed by preventing extracellular regulated protein kinases phosphorylation and NF-κB nuclear translocation .
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PMC11708541
These findings pointed to a future direction for the development of ROS1/ALK dual inhibitors resistant to Crizotinib (Scheme 16).
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PMC11451940
Lapachol (HLap), 2-hydroxy-3-(3-methylbut-2-en-1-yl)naphthalene-1,4-dione, has long been known as a naturally occurring organic compound that can be isolated from the bark of the lapacho tree.
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PMC11700523
α-lipoic acid has various biological actions such as energy modulator and redox modulator, among them great antioxidant potential .
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PMC10926885
The dynamic, reversible alteration of RNA m6A is essential for the development and spread of tumours.
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PMC8540611
Despite cationic charges being required for efficient transfer of genetic material through non-viral vectors, some evidence confirms the high cytotoxicity of such systems.
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PMC10976516
Table 3Clinical applications of systemic OV therapy for lung cancerOncolytic virusVirus constructCombination therapyPhase of developmentMethod and resultsClinical trialsidentifier and referencesAdenovirusAd-HSVtkStereotactic body radiotherapy and pembrolizumabII window of opportunity,Metastatic non-small cell lung cancer (NSCLC).
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PMC11464982
No information is available on oral and respiratory sensitisation or elicitation reactions of this endonuclease.
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PMC11676169
After washing with PBS, DAPI staining was performed to visualize nuclear DNA.
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PMC9429973
All pts in FL cohort with FLT3-i achieved CR/CRi with 60% MRD negative rate as compared to 52% in non-FLT3-I, and 60% of FLT3-i cohort had stem cell transplantation (SCT) in CR1 (vs. 21% of non-FLT3-i).
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PMC11409031
High-dimensional WGCNA (hdWGCNA) is a thorough methodological framework designed to deduce, assess, and understand gene co-expression networks within high-dimensional transcriptomic datasets .
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PMC9428827
Mutein induces a higher anti-metastatic effect than wtIL-2, but the extent of the in vivo antitumor activity was still unexplored.
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PMC11746948
Following this, 250 ng of sequencing-grade trypsin was added to the supernatant, and the mixture was incubated overnight (16 h) at 37 °C with rotation in the dark to perform digestion.
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PMC10470467
Ethical approval was not required for the studies on humans in accordance with the local legislation and institutional requirements because only commercially available established cell lines were used.
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PMC10174970
The cancer-related pathways and each pathway-involved gene were obtained.
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PMC11748618
Significance was determined using linear regression controlling for PC1 and sex.
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PMC10840195
Cell apoptosis was determined by flow cytometry (E).
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PMC10932641
RCC accounts for 2–3% of adult malignant tumors and 80–90% of adult renal malignant tumors and is second only to prostate cancer and bladder cancer among urinary system tumors; however, among these tumors, it has the highest mortality rate (3).
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PMC10887351
In BAT, β3-ARs, through Gsα signaling , promoted lipolysis and thermogenesis via the mitochondrial uncoupling protein 1 (UCP1) stimulation that uncoupled the mitochondrial oxidative phosphorylation.
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PMC11453018
B Western blot analysis confirms the knockdown of P300/CBP at the protein level and reveals decreased levels of acetylated histone markers (acH3K18 and acH3K27) after 48 hours of siRNA treatment. “
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PMC11381192
In another two validation sets (MMRF‐COMMPASS and GSE57317), patients in the high CSI group showed poorer OS outcomes than those in the low CSI group (Figure 2J,K).
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PMC11670954
The TEER value of Caco2 monolayer cells gradually increased with prolonged culture time.
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PMC11088135
6MiR-376a-3p negatively regulates YAP1 expression in U251 cell line.
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PMC10158546
ReN VM neural progenitor cells (Millipore-Sigma cat.
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PMC11635519
A pLJM17 Gia Luciferase vector was generated by PCR amplification of the Gaussia Luciferase gene from the pTK GLuc (provided by the Stagljar lab) using a primer for insertion of restriction sites (EcoRI and XmaI): primer forward 5′-GGAACTAACCGGTCGCCACCATGGGAGTCAAAGTTCTGTTTGCC-3′, primer reverse 5′-CAATGCCGAATTCTTAGTCACCACCGGCCCCCTTGATC-3′. The PCR product was digested and cloned into a pLJM17 lentiviral vector.
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PMC11637276
These data indicate that α2 integrin and MAP3K1 may contribute to invasion, metastasis, and chemoresistance in vivo. (
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PMC9429973
Median follow-up was 30 months.
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PMC9429973
With a median follow of 43 months, (95% CI: 40-47), the survival rates in patients with FL and albumin <3.5 were OS of 83% (vs. 95%) and PFS of 70% (vs. 83%); whereas in patients with NLR >2.15 the survival rates were OS of 91% (vs. 96%) and PFS of 75% (vs. 88%) (Figures 1 and 2; Table 3).
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PMC11247842
For some countries, cows’ and bulls’ data were analysed separately, although they are from the same population and are related.
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PMC10976516
However, the number and type of clinical studies that were specifically performed with systemically administered OV-loaded carrier cells against lung cancer are still limited (Table 3) and mainly used MSCs as carrier cells.
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PMC11240448
Other pathways and signaling hubs, such as MEK/ERK and PI3K/AKT, operate as oncogenic drivers by activating the mTOR and PKC modules.
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PMC2196094
Subsequently, the filters were washed four times at 65°C during 60 min under medium stringency conditions (2× SSC, 0.5% SDS).
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PMC11739504
The following day, the membranes were washed three times with PBST.
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PMC3730428
However, these results demonstrate that although cisplatin can induce downregulation of FLIP(S) in some MPM cell lines, it has little effect on FLIP(L) expression.
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PMC11055443
The Fold Regulation in expressions (A) of Ctx-B (B), TNF-a (C), IL-1B (D) and IL-8 (E) gene in Caco-2 cells treated with secretome (Sec) and Vibrio cholerae compared to control groups.
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PMC9429973
The 10 most frequently used genes for MRD monitoring were NRAS, IDH2, RUNX1, SRSF2, TP53, PTPN11, IDH1, BCOR, CEBPA and GATA2.
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PMC9429973
Effect of ponatinib was only limited.
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PMC11786767
Notably, biotin-DHPE signals were present in the peripheral regions of mitotic chromosomes (Fig. 1A, middle magnified inset), suggesting the presence of lipids in the perichromosomal layer.
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