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PMC9429973
We characterized the effects of Sucnr1 deletion at the molecular level by bulk and single-cell RNA-sequencing (scRNA-seq), and aimed to uncover the molecular mechanisms mediating the effects of Sucnr1 ablation using in vivo tageting with drugs.
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PMC10938336
The potential of compounds 2 and 4, particularly when combined, to effectively target key proteins involved in cancer pathogenesis, underscores their significance as candidates for novel cancer therapies.
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PMC11088135
A–C qRT-PCR was performed to analyze the expression of lncRNA NUTM2A-AS1 and miR-376a-3p in U251 cells.
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PMC11742047
Cells were plated on 96-well plates (Euroclone, Milan, Italy) at 5 × 10 or 1 × 10 cells/cm and, after exposure at the desired time points, 10 µL of CCK-solution was added to each well and incubated for a period of 2 h in a 5% CO2 incubator at 37 °C.
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PMC8540692
It was reported to modulate the activity of kinases and transcription factors as well as to regulate the expression of genes involved in cell survival and malignant transformation .
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PMC11476837
ML-385 increased the CAS-3 mRNA level at 50 µM (p < 0.05).
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PMC10582049
MxIF staining was used to identify tumor cells and ADH1B CAFs.
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PMC11718817
Accordingly, further experiments with NLRP3 inhibitors like MCC950 are warranted to exactly delineate strictly NLRP3-mediated effects.
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PMC11656657
Numerous clinical studies have demonstrated promising results with the use of gene-modified CAR T-cell therapies in the treatment of hematological malignancies , and more recently in solid tumors, including neuroblastoma and H3K27M-mutated diffuse midline gliomas .
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PMC10470467
Necroptosis is a caspase-independent and regulated cell death mechanism which primarily mediated by receptor-interacting kinase (RIPK) and mixed lineage kinase domain-like protein (MLKL) that has been connected to the formation and progression of many cancers and inflammatory illnesses (4–6).
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PMC6627640
Our de novo RNA-seq and bioinformatic analysis did not suggest an alteration in these prior mechanisms of cisplatin resistance.
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PMC3730428
Similar results were obtained with several other SMCs (data not shown).
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PMC10523483
Alignment of our H1.2 ChIP-seq data with ENCODE NRF2 ChIP-seq data (ENCSR584GHV) that obtained in A549 cells indicated overlapping of H1.2 deposition with NRF2 peak within the GCLC promoter region (SI Appendix, Fig. S13B).
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PMC11763111
When compared to autologous CAR-T, off-the-shelf CAR-T treatments for NHL and ALL may lower the incidence of immune effector cell-associated neurotoxicity syndrome (ICANS) and severe cytokine release syndrome (CRS) .
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PMC11594806
Dr. Aoki’s group also investigated CD73 expression in epithelial sarcoma tissue and discovered that CD73 forms a complex with emmprin, a protein linked to the production of matrix metalloproteinase type 2 (MMP-2).
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PMC10723784
Cannabinoids have been shown to induce anti‐tumor activity in a variety of carcinoma cells such as breast, prostate, and brain.
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PMC9429973
Serum was collected at 4 pre-defined time points, namely, just before 1st dose (TP1), 7 weeks after the 1st dose (TP2), 3 months (TP3) and 6 months (TP4) after 2 dose.
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PMC11266100
The findings from the study can be applied to optimize electrotransfection conditions.
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PMC11766332
ASD biology is singularly challenging, including genetic and epigenetic contributions to the effects of multiple environmental factors .
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PMC11026382
Overall both the predicted growth rates and pattern of epistasis showed good agreement to our experimental observations (Fig. 5a, b).
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PMC11792888
This highlights the critical need for new treatment strategies against NSCLC [3-5].
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PMC11543935
Figure 4A shows the result after treatment with the STIMULATE device determining a temperature increase of approximately 10–15 K in the area between the electrodes.
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PMC11772449
Although the existing research results can preliminarily confirm that pirfenidone can inhibit the proliferation of some tumor cells (Zou et al., 2017; Usugi et al., 2019; Lee et al., 1998), reduce the levels of hyaluronic acid and collagen in ECM and increase the pathway of chemotherapeutic drugs into tumors (Polydorou et al., 2017), and normalize the tumor microenvironment, the mechanism of PFD anti-tumor effect is still unclear.
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PMC9429973
Combination iron chelation therapy may be prescribed for patients who do not adequately respond to monotherapy, have increased heart and/or liver iron overload, or have dose-dependent toxicity.
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PMC9429973
Summary/Conclusion: TKIs have revolutionized the treatment of CML.
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PMC11683240
As expected, the change of all residues at the same time for alanine leads to a significant destabilization of the complex, reinforcing their importance in the interactions of α1AT with PT.
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PMC9429973
Immunofluorescence staining was conducted to detect the expression of relative markers on tissue microarrays in patients with AITL.
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PMC7570809
Integrin quantification with Quantibrite PE beads (BectonDickinson Biosciences) was evaluated as previously described .
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PMC11206502
Detected autophagosomes in cells treated with different HB concentrations (0.05–0.4 mg/mL) confirm HB-induced autophagy.
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PMC11577421
The experiments consisted in recording DLS data for the NPs in the presence of increasing concentrations of heparin.
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PMC11590005
This reasoning is also consistent with the lower B-MRS sum-score observed among the students with the highest socioeconomic status, particular-ly compared to those of the lowest socioeconomic group.
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PMC8956657
In this regard, we have examined the binding mechanism of the HKU5 ORF4b NLS bound to IMPα, which indeed uses a canonical Lys P2 binding mechanism (Fig. 7C, D).
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PMC11549062
Immunoprecipitation (IP) was used to further explore the interaction among PTP1B, Rab5, and PDGFR‐β, and the results suggested that PTP1B interacted with Rab5 and PDGFR‐β (Figure 4G).
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PMC11779605
The horizontal line indicates the mean. (
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PMC10391797
In recent years, preclinical studies of chimeric antigen receptor T (CAR-T) to treat acute myeloid leukemia (AML) have yielded promising results.
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PMC11155445
In addition, extensive intermolecular H-bonding and π–π stacking between aromatic parts was also observed.
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PMC10969097
In another study, Gil-Ramírez et al. analysed various parts of Agaricus bisporus and parts generally discarded by the mushroom marketing industry, which showed significantly higher inhibitory properties compared to the commercialised parts.
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PMC10745221
al derived a less methionine-dependent revertant cell line from the methionine-addicted human osteosarcoma 143B cell line that demonstrated improved survival at high levels of recombinant methioninase (rMETase) treatment .
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PMC9429973
E. Viry, A. Largeot, S. Gonder, S. Chemlal, N. Kiweler, J. Meiser, T. Helleday, E. Moussay, J. Paggetti Tumor Stroma Interactions, Department of Cancer Research; Cancer Metabolism Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institute, Solna, Sweden Background: Chronic Lymphocytic Leukemia (CLL), the most common type of leukemia in adults, is characterized by the clonal expansion of CD5 CD19 B cells.
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PMC10529414
Tissue samples from 5 patients with NSCLC of primary origin and 6 patients with NSCLC of metastatic or secondary origin, each of which was verified histopathologically (Table 1), were used in this study.
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PMC9429973
Years were defined as financial rather than calendar years (starting 1 April) both conventionally and since this coincided approximately with lockdowns allowing easy comparison with preceding years.
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PMC7917457
Most importantly, we saw significantly higher numbers of tumor-infiltrating, OVA-specific cytotoxic CD8 T cells in PeptiCRAd VALO-mD901-OVA-treated tumors compared to other treatment groups.
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PMC11640419
Samples were then analyzed on a NovoCyte Penteon flow cytometer (Agilent, USA).
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PMC11448304
The COG/KOG dataset was also applied to sort the DEPs into four categories (Fig. 3e).
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PMC8996378
All compounds were tested for their biological activity against MDR on ABCB1-dependent MDR cancer cell line HepG2/ADR, and compounds 60–62 were identified as potent MDR modulators (Table 19).
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PMC11783017
Therefore, BRD4 inhibitors are also considered as MYC inhibitors.
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PMC11013014
2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)-N-(2-(3-(p-tolyl)ureido)ethyl)acetamide (16a).
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PMC10452486
The possible role of Face-2 oligomerization (formation of Face-3 and Face-4) was further studied on a B lymphoblastoid cell line, JY .
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PMC11792090
Oligodeoxynucleotide (ODN) tags were introduced during the CRISPR/Cas9-mediated knockout of CAR-T cells, and DNA was extracted from the cells one day later.
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PMC11348300
Optimal discrimination was achieved at the 1-h time point following the injection of ALA.
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PMC11733919
After each coating, functionalization, and bioconjugation step, the determination of iron concentration was performed following a previously reported protocol.
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PMC10529414
We found a critical contribution of the RUNX2 TF in transcriptional repression of TALAM1 in lung adenocarcinoma.
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PMC11389534
The endocrine system interacts with the immune system through hormonal feedback mechanisms.
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PMC7582629
Moreover, RS combined with the PCA method was attempted to visualize and extract useful information from multivariate spectral data to examine qualitative differences among all types of samples.
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PMC11138140
However, at 24 h, the average optical volumes of the individual untreated cardiomyocytes (n = 256) were 1341 ± 473 μm and that of the norepinephrine-treated cardiomyocytes (n = 187) were significantly increased to 1492 ± 501 μm.
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PMC9429973
Cytopenias occurred in all patients.
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PMC11583690
The cells were then incubated for 4 h at 37 °C (5 % CO2).
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PMC11607638
The gene sequence was inserted into pcDNA3.1 vector to get pSKR‐cDNA3.1 .
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PMC5035325
4T1-metastasis model: BALB/c mice were transplanted subcutaneously (s.c).
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PMC11687167
③ CAP1 binds to CHRD and promotes degradation of the PCSK9-LDLR complex in lysosomes.
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PMC9429973
Furthermore, the patient had hypogammaglobulinemia, and the ‘transitory CD21 low B-cells’ were significantly increased, reflecting impaired lymphocyte maturation possibly causing the autoreactive phenotype of the disease.
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PMC11471176
Notably, carnosine increased the proliferation of a cell line in a study, through the AKT pathway in pigs, which was utilized to grow muscles in pigs, even though ACE2 was absent in their investigations .
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PMC11544771
Nevertheless, the above results suggest that the decreased expression of Cdc25A and/or Cdc25B/C may also partly contribute to the enhanced anti-proliferative effect of the CPX/PRE co-treatment.
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PMC11791264
We introduced HA-SETD7 or HA empty vector into LC3B overexpressing HEK293T cells.
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PMC11075223
Hormone/estrogen replacement therapy increased the risk of stroke and breast cancer during treatment if used for a long time .
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PMC11736898
D is metabolized to 1,25-dihydroxyvitamin D (1,25(OH)2D), the hormonally active form of vitamin D, by CYP27B1.
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PMC11753435
The SS18-SSX1 fusion protein is believed to function as an aberrant transcriptional regulator hijacking the activity of the normal BAF complex and driving oncogenesis (46).
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PMC9429973
Regarding Performance Status, 22/52 (42.3%) had an ECOG 0, 25/52 (48.1%) 1 and 5/52 (9.6%) ≥2.
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PMC11352877
The effect of VEGF transcription factors is mediated by their receptors, VEGFR1 and VEGFR2, which act through the tyrosine kinase pathway (also involved in angiogenesis); it is also mediated by VEGFR3, which is engaged in lymphangiogenesis .
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PMC11515150
Finally, the strict monomeric behavior of VHH has a role in retaining the protein stability and binding affinities , and yielding a highly modular platform without requirement for extensive reformatting.
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PMC6133382
Cell-doubling time in hours was calculated using the formula ((T2 − T1) × log2) / (log(D2) − log(D1)), where T = time at count and D = density at count.
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PMC10362265
To scrutinize the contribution of the intermolecular disulfide bonds in the tetra-partite assemblies, we have generated the tetramers with and without the intermolecular bond(s).
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PMC10213179
Data are presented as means ± SD.
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PMC9261184
This is lower than what may be considered optimal from an overall fuel use energy efficiency perspective but gives substantially higher methane slip as well.
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PMC9429973
Secondary endpoints are complete response (CR) rate at the end of the reinduction block and characterization of BCR::ABL1 domain mutations before and after PON treatment.
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PMC9429973
Similarly, consolidation with allogeneic stem cell transplantation (HSCT) was correlated with higher OS.
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PMC11657695
After the staining, the crystal violet was solubilised in Sorensen solution, and absorbance at 570 nm was measured with Victor (Perkin-Elmer).
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PMC11473750
The sections were developed with 3, 3’-diaminobenzidine tetrahydrochloride (Dako, K3468) at room temperature for 5 min.
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PMC10329074
As depicted in Fig. 3A-C, no significant correlation was established between overexpressed YBX3 and tumor histological grade (grade 3 & 4 vs. grade 1 & 2; P > 0.05).
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PMC9429973
However, these clinical results have not yet been repeated in real world cohorts with long term follow-up.
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PMC11277157
Figure 5A shows a Venn diagram of the experiment groups.
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PMC11767817
On the other hand, compound 2a-B significantly increased caspase 3/7 activity in a dose- and time-dependent matter.
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PMC11770199
Curves of melanoma tumor growth with the treatment of NS, mMSCs-GFP, and mMSCs-p14.
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PMC11045125
Although our studies here used naïve cord blood B cells rather than germinal center B cells to induce lymphomas, the model could be easily altered to use primary tonsil GC B cells, as recently described in a model system for human DLBCL tumors .
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PMC10440586
Anti-tumor immunity, such as activation of cytotoxic T cells (CTLs) in the tumor microenvironment (TME), also poses stress to gliomas .
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PMC9429973
Methods: This is an interim analysis of an ongoing phase 2 clinical trial of a planned 28 newly diagnosed adult HLH patients.
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PMC11301242
Additionally, it is noteworthy that co-amplification of protein-coding and non-coding elements was observed on ecDNA amplicons.
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PMC11711066
Our findings help in understanding the actions of Hozai, which may be an option for the prevention and treatment of cardiovascular diseases in older adults.
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PMC7553912
Prevalence of kidney stone disease has, therefore, steadily increased in most countries, including the United States and Japan.
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PMC9429973
Spleen and symptoms response (SR/SyR) were defined according to IWG-MRT criteria.
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PMC11502066
In plants, flavonoids have several important functions, contributing to protection against biotic and abiotic stressors, pigmentation, pollinator attraction and seed germination .
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PMC11740573
This may have important implications for the treatment of many bacterial infections and may be used in the development of new drugs to treat infections caused by resistant strains of bacteria.
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PMC6442998
qPCR: mRNA level of PDE3A and its transcription factor SFPQ were significantly lower in GIST48 cells compared to GIST882 cells.
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PMC11612794
Based on these results, we propose that CENP-T phosphorylation contributed to facilitating the CENP-T-Mis12 interaction (Figure S6E; see discussion).
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PMC11512230
The reason we chose A673 cells is that they will be utilized for the in vivo binding experiments of AltMV SPV and TMV SP as well as the delivery of therapeutic payloads.
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PMC11258145
The MTT method was employed to assess viability, and its outcomes directly align with the number of surviving cells.
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PMC9024365
For quantitative analyses, images were taken using either an Olympus FluoView 1000 or Zeiss LSM510 confocal microscope with a 63 × /1.5 NA oil objective with identical settings for laser power, photomultiplier gain, and digital offset.
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PMC10329074
Data were expressed as the mean ± s.d.,
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PMC9429973
Seven marrows from AML patients in complete remission after induction chemotherapy (AML-CR) were used to evaluate NK cell and receptor recovery.
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PMC11434983
The medium was refreshed every three days while cells were incubated at 37 °C 5% CO2 for 14 days.
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