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PMC9429973
Results: As of 27 September 2020, 323 pts (170 CLL/SLL, 61 MCL, 26 WM, 26 DLBCL, 13 MZL, 12 FL, 9 RT, and 6 other NHL [other transformation, B-PLL and hairy cell leukemia]) were treated on 7 dose levels (25-300mg QD).
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PMC11306331
Qualitatively, we observed no illumination-induced changes in 3xFUS condensates in cells lacking a solubilizer construct or expressing GST, mEGFP, or mEGFP-mEGFP.
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PMC11551844
Campesterol showed apoptosis on U937 (human monocytic) cells and esophageal adenocarcinoma.
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PMC6617630
Bar represents mean ± SD for three replicates from three different experiments. *
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PMC11240448
cSTAR analysis revealed that luminal BC cell lines exhibit more uniform signaling networks compared to basal BC cell lines.
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PMC11762280
The proteins that constitute PANoptosome include three types: (1) PAMPs or DAMPs sensors, such as ZBP1, AIM2, NLRP3, and NLRP12; (2) adapters, such as FADD and ASC; (3) catalytic effectors, such as RIPK1, RIPK3, caspase-1, and caspase-8 .
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PMC10589262
Cell growth was measured by MTT analysis 72 h after BLZF1 shRNA treatment.
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PMC11769516
Cytotoxicity and reduced viability were observed in neuroblastoma cells treated with the extract, despite the fact that the “regulated mycotoxins” were present in lower concentrations than the EU recommends for animal feed (ENN and BEA were also detected in small amounts).
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PMC11739504
α-tubulin represented as cytosol marker and histone H3 as nuclear marker. (
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PMC11300085
We identified that chemerin functioned as a promotion factor for SK-OV-3 cell proliferation and migration through CMKLR1/RhoA/ROCK-mediated EMT.
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PMC9429973
Aims: The aim of present meta-analysis was to compare the efficacy and safety of CAR-T vs. high dose chemotherapy followed by ASCT as second line treatment for R/R LBCL.
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PMC11762280
F Proteins of N-GSDMD, cleaved PARP, cleaved caspase-3, and p-MLKL were detected by western blotting assay in epidermal lysates of control, 215 mJ/cm UVB 72 h, and 430 mJ/cm UVB 72 h groups of mice (sacrificed on the same day).
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PMC11322866
RRM2 EV and RRM2 OE cells were stained with DAPI (blue).
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PMC9910796
Data are expressed as a percentage (± SD) of positive labeling (>1 gold particle/virus particle) detected in control vEP84Ri (+IPTG) viruses.
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PMC11594074
Poses were generated using the triangle matcher method and scored by London dG in MOE .
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PMC6835428
KSP regulates microtubule organization and spindle assembly during eukaryotic cell division ; thus, its targeting can abrogate cell proliferation.
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PMC11682172
In addition, coronin-1A levels in the cancer cells also remained low following incubation with activated T-lymphocyte conditional medium.
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PMC11534035
Treatment of A431 cells with 2.5 μM G1 (M=10.65±1.54 px vs. control; p<0.0001) and with 5 μM G1 (M=10.40±1.98 px vs. control; p<0.001) resulted in significant decrease in colony size compared to control colonies.
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PMC9878278
This response in SC follows the same trend as seen in other human cell types such as Huh-7 cells, where poly I:C treatment induced IFN-β and ISGs, and attenuated ZIKV infection (Tricot et al., 2018).
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PMC11798926
Furthermore, AVPA surface puncta were larger than WT SynDIG4 surface puncta, while PSD95 puncta size did not differ between the AVPA and WT SynDIG4 groups (Figure 5C).
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PMC5025404
After an initial screening of the clones in 96-well plates using ELISA, were selected 68 clones that had the highest expression level.
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PMC11730305
Fig. 9MTT assay showed that the IC50 of Co3O4@Glu-Ellagic acid for normal human cells (a: HEK293) and liver cancer cell lines (b:HepG2, c:Hep3B) were 187, 94 and 87 µg/mL, respectively.
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PMC2193049
Purified MAGE-3256–279 and MAGE-3271–285 peptides were incubated for 40 min in the presence of proteasome and 50 μM lactacystin and analyzed by mass spectrometry (Fig. 4, C and F).
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PMC11204465
The specific reaction process was as follows.
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PMC9429973
This pathway may have evolved to cleanse DNA damaged stem cells and maintain the HSC pool.
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PMC3888431
About 16% (4,823) of the transcripts are single-exon transcripts.
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PMC8875242
The concentration of [H]-digoxin was quantified using a Tri-Carb 2900TR liquid scintillation analyzer (Packard Bioscience, Meriden, CT, USA).
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PMC11791203
Fig. 3Effect of chloroform extract of H. malabarica on apoptosis in HT29 cells following 48-hour treatment.
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PMC2196094
The cDNA was ligated into the single EcoRI site of the λ−gt 10 vector and the ligated DNA was packaged into phage particles with an in vitro packaging system (Stratagene, La Jolla, CA).
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PMC11711935
Recent studies demonstrated that fibroblasts influence pigmentation, and their impact on melanocyte activity and metabolism has attracted interest.
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PMC8382973
The concentration of the peptide was measured by UV absorbance and theoretically calculated by the molar extinction coefficients of tryptophan and tyrosine residues.
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PMC11544122
n.s.
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PMC9370419
The primer sequences were as follows: β-actin, forward 5′-GCACTCTTCCAGCCTTCC-3′, reverse 5′-GGTCTTTGCGGATGTCC-3′; pgRNA, forward 5′-GCCTTAGAGTCTCCTGAGCA-3′, and reverse 5′-GAGGGAGTTCTTCTTCTAGG-3′. The Northern blot procedures followed the DIG Northern Starter Kit.
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PMC5574817
7A representative image showing the Western blot analysis of the hERG protein expression in hERG-transfected and non-transfected HEK293 cells.
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PMC7351993
The IA node is equipped with a multi-core CPU, two solid state drive (SSD) storages, and 10-Gbps Ethernet ports.
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PMC10125312
Cellular viability (%) after treatment assessed with MTT assay. (
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PMC11670954
As urbanization and economic development progress, humans continues to produce an increasing variety of hazardous substances, which pose a significant threat to the integrity of this protective barrier .
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PMC11283030
Though TIMER2 and TISIDB databases analysis, we found that ACLY gene was not only significantly correlated with numerous immune cells including CD4+T cell, macrophage and neutrophil, but also predominately associated with massive immunoinhibitors, such as CD274 (PD-L1) and PDCD1LG2 (PD-L2), which indicates that ACLY is closely related with immune infiltrates of ccRCC.
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PMC11725127
The previously identified KRAS-associated DUBs include OTUB1 and USP18; however, neither of them directly deubiquitinates KRAS.
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PMC10452486
They have demonstrated that the HLA-G dimer inhibits the activation and cytotoxic capabilities of human CD8+ T cells.
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PMC11377827
Immunoblot is representative of three biological replicates. (
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PMC6268318
The extract also delayed gastric emptying in rats in a dose-dependent manner.
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PMC11755519
Furthermore, lncRNA-UCA1 itself increases the proliferation of migration and invasion of bladder cancer cells, which is associated with tumor growth and progression.
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PMC10957991
Tubulin acts as a loading control. (
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PMC11545737
Bacillary dysentery is characterized by intestinal inflammation, abdominal pain, cramps, diarrhea and fever, and accounts for more than 250 million cases worldwide each year .
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PMC11661024
By detecting an internal signal such as DNA damage, the Bax and Bak proteins are actuated to generate pores in the outer mitochondrial membrane.
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PMC10545062
This is a significant finding as increased crystalloid utilization can exacerbate coagulopathy, inflammatory response, hypothermia, acidosis, and lead to mortality.
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PMC11721096
As a key rate-limiting enzyme in melanin synthesis, tyrosinase influences the pigmentation of human skin, hair, and eyes .
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PMC11695623
Inhibition of B4GALT1 can increase the abundance and activity of CD8+ T cells and enhance the anti-tumor immunity of anti-pd-1 therapy in vivo.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inhibition", "of", "B4GALT1", "can", "increase", "the", "abundance", "and", "activity", "of", "CD8", "+", "T", "cells", "and", "enhance", "the", "anti-tumor", "immunity", "of", "anti-pd-1", "therapy", "in", "vivo", "." ] } ]
PMC10940855
G, Created with BioRender.com.)
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PMC11672142
In Jurkat cells, Ti(Def)2 arrests the cell cycle at the S phase, indicative of suppressed DNA replication likely from RNR inhibition.
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PMC2193049
All of these observations can be explained by the presence of unfavorable amino acids surrounding the cleavage site and acting as “negative processing signals.”
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PMC11739484
Subsequently, the expression patterns of MMP7, MMP11, and MMP14 were investigated in SKCM by leveraging additional cohorts.
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PMC10877303
8The binding-free energy of the top three drugs and inhibitor complexes calculated by the MM-PBSA method.
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PMC9429973
On cardiac MRI, the most frequent features were: left ventricular hypertrophy (100%), delayed myocardial enhancement (50%), and abnormalities in myocardium nulling (40%).
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PMC8494202
Several drugs with potential inhibitory effects on CKAP2L were identified in the CMap database that may have therapeutic effects on glioma.
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PMC11739484
To further validate the connections between MMP7, MMP11, and MMP14 expression and DNA methylation, the methylation levels of these genes in SKCM tissue samples were assessed using the MEXPRESS database.
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PMC11352877
The development of the vascular system in the human endometrium is controlled at the physiological and pathological level by the regulator of tissue morphogenesis, TGF-β1; it is also a potent inhibitor of the proliferation of most cell types .
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PMC11585565
Nonspecific binding was blocked by incubation with 3% (v/v) FBS and 10% (w/v) bovine serum albumin (BSA) in PBS for 1 h. The anti-FLAG primary antibody (clone M2, Sigma-Aldrich) was diluted with blocking buffer to 1:500 and incubated at 4ºC overnight.
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PMC11699465
This indicates that TMEM199 knockout does not impact the PD-L1 degradation.
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PMC9429973
These results suggest that APL patients with high BCL2 expression differ in their metabolic and proliferative state compared to patients with BCL2.
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PMC10213199
Differentially expressed genes (DEGs) in the Drosophila treatments were identified (Table 1) using sequencing and comparison analysis.
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PMC9429973
Metabolic changes were evaluated by ECAR and OCR assessment using Seahorse analyzer.
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PMC11694625
Moreover, normal human liver cell line HL-7702 was chosen to investigate the cytotoxic activity of 3a–3d against normal human cell lines.
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PMC11718817
NLRP3 activation status of these macrophages did not significantly influence the percentage of infiltrating CTLs.
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PMC11774251
RNA-seq analysis of Tan-I effects on TNF-α-stimulated HaCaT cells. (
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PMC9429973
Aims: The REMNANT study will evaluate if treating MRD relapse after 1.L therapy prolongs progression free survival (PFS) and overall survival (OS) compared to starting treatment at biochemical relapse/progressive disease (PD) in MM patients.
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PMC11777207
After five consecutive days of topical IMQ application, we observed increased epidermal thickening, a result of keratinocyte hyperproliferation, compared to untreated mice (Fig. 7, B to E).
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PMC9429973
However, there are little data on efficacy and safety in children ITP and still lacks predictive marker for efficacy.
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PMC11224020
Six-well plates with a glass bottom were used for cell imaging (MatTek, P06G-1.5-20-F).
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PMC11506670
Once the spheroids had formed after 72 h, 50% of the media was removed, and 50 µL of CellTiter-Glo 3D Cell Viability Reagent (Cat No. G9681, Promega, Madison, WI, USA) was added.
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PMC11462929
However, amplification was specifically accumulated only on chromosome 8 in 44 (61.1%) out of 72 BCP‐ALL cell lines, particularly in the 8q24.21 region in 35 (48.6%).
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PMC7868205
As an initial analysis, microscopic observations indicated the annihilating effect of AgNPs towards HEK-293 and HeLa cells (Figure 4A and B).Figure 4Microscopic observations of the cytotoxic effects of AgNPs on (A) HEK-293 cells (B) HeLa cells.
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PMC10809689
Our results indicated that the cell proliferation rate was increased in the PMA + Gal-9 group in comparison to the PMA and control group (p = 0.001) in both HL-60 and THP-1 cell lines (Fig. 6 (a., b.)).
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PMC9739791
Both prodrugs demonstrated a 3–7-fold increase in toxicity when cells were irradiated (400–760 nm, 4 mW/cm, 30 min) compared to cells incubated in the dark.
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PMC9429973
Before the endovascular therapy, the average of hemoglobin level was 13,12 g/dl and the corresponding 95% confidence interval 13,12±1,45,and 24 hours after the treatment the average was 12,49 g/dl and the confidence interval 12,49±2,02.
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PMC11411004
Briefly, during the logarithmic growth phase, CHO-ADM cells were gathered, and a suitable quantity of TRIzol was administered to each set of cells, which were completely lysed and collected at low temperature.
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PMC11435360
IHC staining was performed by incubating the bladder sections with antibodies against the apoptotic markers caspase-9 and cleaved PARP-1, the neovascularization marker VEGF, the proliferation marker Ki67, and the macrophage markers F4/80 and CD163, as well as the T-cell markers CD8 and CD4 (Abcam, Toronto, ON, Canada).
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PMC11686380
Thus, the p.E111K substitution might affect the phosphorylation of the adjacent serine 110 residue and subsequently change protein stability.
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PMC8984067
Regarding IR spectrum for UCNPs-Ce6, peaks appearing at 3422, 2967, 1652, 1541, 1455, 1267, and 1116 cm corresponded to N-H and O-H and/or C-H stretching vibrations, C=O stretching vibrations, N-H bending vibrations in amide, C-H stretching vibrations, C-N stretching vibrations, and C-O stretching vibrations, respectively.
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PMC11773391
We believe that this may be related to acquired drug resistance, and some cells that were originally sensitive to TMZ may develop chemotherapy resistance by promoting MGMT transcription.
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PMC11055323
d Heatmap shows the intensity changes of H3K27ac occupancy at SS18-SSX1 binding sites upon expression of the onco-fusion protein.
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PMC11679033
While single CIT was able to elicit a response in terms of different degrees of DNA damage in individual cells, after treatment with single CBD and CIT + CBD, the ranges of measured values were narrower.
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PMC11676674
MMC has been demonstrated as genotoxic in all in vitro and in vivo test systems in mammalian cells and animals, and it has been clearly established as a carcinogenic agent .
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PMC9429973
Therapeutic treatment was initiated eight days after tumor implantation once tumors were established.
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PMC11585565
In this study, to deepen our comprehension of the pathogenic mechanism underlying JS, we conducted functional studies of the variants, p.(Gly492Asp) and p.(Gly492Cys), both entailing substitutions at the Gly492 position, as well as the well-documented variant, p.(Thr495Ile) situated within the Mg-ATP binding pocket.
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PMC11126803
There are four putative EREs located within the ZEB1 promoter region (ERE#1 at −2857nt to −2843nt, ERE#2 at −1592nt to −1578nt, ERE#3 at −1376nt to −1362nt, and ERE#4 at −151nt to −137nt) (Fig. 5C).
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PMC9429973
In preclinical studies, rituximab augmented CD19 chimeric antigen receptor (CAR) T-cell function and increased tumor reduction and survival in murine models via synergistic targeting with CAR T-cells (Mihara K, et al. Br J Haematol.
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PMC3995603
The plasma levels of histamine (A) and IgE (B) in D. farinae extract-sensitized Nc/Nga mice.
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PMC11045125
Suppression of Myc-induced apoptosis, often through mutation of the TP53 (p53) gene or inhibition of pro-apoptotic BCL2L11 (BIM) gene expression, is required for development of Myc-driven BLs.
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PMC11591038
Using VEGF-expressing adeno-associated virus (AAV-VEGF) driven by the GFAP promoter that allows VEGF expression exclusively in astrocytes, it was demonstrated that the AAV-VEGF may reverse the ApoE4-related Aβ42 aggregation and accumulation of hyperphosphorylated tau proteins .
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PMC9429973
Patients were divided into two groups; group A, those belong to the category of high platelet level for transfusion (such as those with bleeding, high fever, rapid fall in platelet count, impaired platelet function or undergoing invasive procedures) and group B, those who were not.
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PMC7823217
However, considerable differences in the molecular signaling, protein and gene expression, cell phenotype, cell migration, cell viability, cell proliferation and drug response, have been observed between 2D and 3D cancer models .
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PMC11366496
The downside represents the histogram.
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PMC10114490
Alternatively, unsupervised analysis was performed by variance stabilizing transformation which includes log transformation.
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PMC10777969
Recently, we expanded our FCP collection with two novel compounds.
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PMC11088135
G Western blot assay was conducted to analyze the protein expression of Bax and Bcl-2.
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PMC9429973
Results: We registered 149 patients during the study period.
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PMC10812665
The overall metabolic situation was characterized by oxidative stress, an over-abundance of NADH (>1000% increase) and a re-routing of metabolism in order to dispose of the nitrogen resulting from increased amino acid turnover.
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PMC10938377
The purity of the conjugates was determined by analytical HPLC (Fig. S7†).
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