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OTAR3088
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BioData-CellLine_annotated

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PMC7553912
On day 6, the mRNA expressions of TNF-α, IL-1β, F4/80, and MCP-1 in OSMRβ mice were significantly suppressed, compared with those in WT mice (Fig. 3d–g).
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PMC11782780
The sk-br-3 cells were transfected with miR-301b-3p mimic or NC mimic.
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PMC11777207
Expression of CD80 from the MIGR1 MSCV constructs in Cd80 GM-CSF–derived BMDCs at day 7.
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PMC10197932
Images were taken by CCD Camera mounted on light microscopy and using NIS-elements Imaging Software (Nikon).
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PMC11770199
For the melanoma model, same grouping and treatment dosages were used with a slightly altered timeline.
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PMC9429973
Aims: The aim of our study was to assess the clinical and prognostic significance of oxidative stress markers in patients with untreated diffuse large B-cell lymphoma (DLBCL).
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PMC11543885
Pathway Enrichment Analysis.a.
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PMC11640247
Further investigations are essential to clarify how these variants differentially disrupt neuronal migration at the molecular level.
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PMC11786704
The PC capsule-treated group showed better wound healing than the others.
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PMC7171147
ES2 cells cultured on COL11A1-positive extract exhibited a significant decrease in cell death upon cisplatin treatment, compared to ES2 cells cultured on COL11A1-negative extract (Fig. 5a; 13.2% vs. 21.6% cell death, p < 0.01).
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PMC11772585
The EdU Apollo DNA in Vitro Kit (C0071S, Beyotime, China) was used to evaluate cell proliferation following the manufacturer’s instructions.
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PMC9261184
Typically, one main engine and one generator were being monitored at a given time.
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PMC11400680
YOLOv9-E, You Only Look at Once version 9 extended.
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PMC11348300
However, the experiment was not further pursued due to mixed outcomes observed at the early stage.
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PMC11247842
Based on MR-MEGA and MTAG analysis, we detected novel QTL for CM and SCS compared with single trait, single breed analysis.
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PMC11785489
For statistical power in this analysis, we used relatively coarse clusters to define transcriptional states (A1–A9; Figure 1A).
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PMC9545474
The absence of toxicity of 1 and 3 was confirmed against non‐immortalised lymphocytes taken from the blood of healthy individuals.
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PMC9672323
The effect of dexamethasone and piroxicam was measured on the TGF-β levels of T cells in PBMCs alone (a, d), U-87 MG cell line (b), A-172 cells (e), and in the co-culture with U-87 MG (c) and A-172 cells (f) (n = 4).
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PMC11380454
AS101 is a nontoxic tellurium(IV) immunomodulating compound that has been shown to have beneficial effects in diverse preclinical and clinical studies 24-32.
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PMC10874773
The insecticidal activity of anisatin and pseudoanisatin on German cockroaches was moderate (Wang, Hu, Huang, & Qin, 2011).
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PMC5386478
The expression levels of the constitutively spliced full-length TGM2-v1 and of four TGM2 variants (TGM2-v2, v3, v4A, v4B), generated by alternative splicing, were evaluated by real-time PCR in mesothelium and MPM derived cell lines.
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PMC10142392
The results demonstrated that the amphiphilic copolymers effectively transported both substances.
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PMC11783017
The results showed a mild downregulation of IL-11Rα expression by Lipo-IL11, which is consistent with the selective binding and killing of IL-11Rα-overexpressing tumor cells (Fig. S10).Fig.
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PMC11803149
We next sought to explore the possibility that reduction of Epas1 expression is involved in impaired anti-tumor responses of aged CD8 TCR-T cells.
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PMC11297139
Considering that ARID1A LLPS opens EWS/FLI1 binding sites (Fig. 4d, e), we further tested whether EWS/FLI1 binding is associated with cREs that control ARID1A LLPS-dependent upregulated genes.
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PMC11678841
To further explore the effects of GA on the VECs’ immune response to C. albicans, we assessed the levels of IL-6, IL-1α, and IL-1β, the pro-inflammatory cytokines produced in response to C. albicans hyphae or to candidalysin through the activation of different signal transduction pathways that include p38 SAPK .
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PMC11001582
Graph, mean ± s.e.m.;
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PMC11703896
The percentage of growth inhibition was determined using a formula, and the lethal concentration 50 value (LC50) was calculated utilizing ED50 PLUS V1.0 Software.
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PMC11144200
The anticancer effect of sustained effector T cells is shown to be more enduring, and there is a persistent elevation of TNF-α as well as IFN-γ in mouse serum.
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PMC9429973
Different TP53 gene states have different prognostic effects on MDS and AML, and whether allogeneic hematopoietic stem cell transplantation can overcome this undesirable factor needs to be further explored.
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PMC10652261
Anticancer drugs, in general, damage not only cancer cells but also normal cells, and therefore, their use in cancer therapy frequently results in severe toxicity and adverse effects.
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PMC10988555
If the damage is not repaired, cell death can occur.
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PMC11707577
Following the in vitro assessment of the biosafety of M13EGFR(TNP) in dark conditions, in vivo assays were performed with Hydra vulgaris, a model organism successfully employed to test toxicity and bioactivity of both inorganic and organic compounds.
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PMC8316344
Images of all the immunoblots are representative of three independent experiments.
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PMC11055510
Based on previous studies (Fan et al., 2019; Xie et al., 2019; Zhou et al., 2021; Lin et al., 2021; Lin et al., 2020; Zou et al., 2018), we analyzed some circRNAs that can affect OC progression and early diagnosis, namely, circABCB10, circMAN1A2, circEPSTI1, circ-ITCH, circHIPK3, and circLARP4.
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PMC6803987
Samples treated with esculetin exhibited dose dependent improvement of the hepatocellular architecture compared with the model group.
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PMC9429973
These differences in NFκB signalling state result in distinct predicted response to NFκB targeting therapeutics.
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PMC11549612
In cancer, the BOLA family genes have been implicated in diverse molecular pathways that influence key hallmarks of cancer, including proliferation, survival, migration, and metastasis.
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PMC11666785
and sub-optimal sample preparation.
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PMC11697189
Cells were seeded into the apical chamber with 5% FBS-containing medium, while the basolateral chamber was filled with 15% FBS medium.
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PMC11448304
Next, we analyzed the differences in Khib modification sites between RA549 and A549 cells.
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PMC7723249
Thus, we decided to compare levels of IL-6, IFN-γ, TNF-α, IL-8 and IL-10 in supernatant from HAZV- or CCHFV-infected moDCs.
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PMC9429973
The difference was also not significant depending on the mobilization regimen used, despite the trend towards a negative effect of less intensive courses in the case of a significant volume of residual cells.
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PMC11676670
These challenges demand new, well-characterized cell lines that maintain the histological and molecular characteristics of HGSOC.
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PMC11087766
PhiKZ RecA was also imported into the PhiPA3 nucleus.
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PMC8358006
Columns represent the region from −5 kb with respect to the transcription start sites (TSSs) to +10 kb with respect to the transcription end site (TES).
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PMC11354225
PpIX shows intrinsic fluorescence; therefore, it could be detected by flow cytometry.
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PMC11587541
However, 47.5% were males, 52.5% were females in cases & 62% were males, 38% were males in controls.
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PMC8735881
I-K) The anti-HIV activities of CMI02 and CMI06 in human primary CD4 T cells.
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PMC9429973
Image: Summary/Conclusion: We have developed a reliable, easy-to-use msPCR assay suitable for IGLV3-21 screening in large cohorts.
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PMC9429973
C. Cumbo, F. Tarantini, A. Zagaria, L. Anelli, C. F. Minervini, N. Coccaro, G. Tota, L. Impera, E. Parciante, M. R. Conserva, I. Redavid, P. Carluccio, M. Delia, A. Giordano, C. Longo, T. Perrone, A. Russo Rossi, G. Specchia, P. Musto, F. Albano Department of Emergency and Organ Transplantation (D.E.T.O.) - Hematology and Stem Cell Transplantation Unit; School of Medicine, University of Bari, BARI, Italy Background: Inflammatory bowel diseases (IBDs) are a group of chronic relapsing conditions of the gastrointestinal tract.
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PMC9596868
This could be because of low dosage of MST-312 and early time point of analysis which we selected, because upon increasing treatment time, cells in the combination treatment set underwent apoptosis limiting the amount of sample available for analysis.
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PMC11509224
Compounds 35 and 37–39 are the second examples of 8′-oxo-agelasine analogs.
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PMC11574029
To further investigate the biological function of NOTCH3 in BLCA, we screened three small interfering RNAs (siRNAs) and selected the one with the highest knockdown efficiency to construct a stable NOTCH3 knockdown cell line (Supplementary Fig. S1).
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PMC11129910
The formula to calculate tumor volume was as follows: (length × width)/2.”
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PMC9031474
Therefore, ROS could be a link between the detergent effects of drimanes and coloratanes on the MM and DNA damage.
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PMC8073654
The isolates, (E)-4-(3′,4′-dimethoxyphenyl)but-3-en-1-ol (2), (E)-4-(3′,4′-dimethoxyphenyl)but-3-enyl acetate (3); cis-3-(3′,4′-dimethoxyphenyl)-4-[(E)-3′′′,4′′′-dimethoxystyryl]cyclohex-1-ene (4); cis-3-(3′,4′-dimethoxyphenyl)-4-[(E)-2′′′,4′′′,5′′′-trimethoxystyryl]cyclohex-1-ene (5); and cis-3-(2′,4′,5′-trimethoxyphenyl)-4-[(E)-2′′′,4′′′,5′′′- trimethoxystyryl]cyclohex-1-ene (6) from this fraction exerted topical anti-inflammatory activities with ID50 values of 47, 62, 21, 20, and 2 μg/ear, respectively (diclofenac, ID50 61 μg/ear).
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PMC11727145
The experiment was performed with two different DED lots.
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PMC8097906
d IC50-value calculations for VSM on 48 h extract treated RMA cell line RH-30 (see Fig. 1a) and HA-OH1, as well as healthy hMSCs and NHDF control cells.
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PMC10809689
Alexandr Prokhorov et al., have shown that the TIM-3 activation by galectin-9, triggers growth factor type responses by stimulation of the PI-3 K/mTOR pathway in AML cells especially in THP-1 cells and also VEGF production and induced S2448 mTOR phosphorylation were shown time-dependent .
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PMC6642070
Pitavastatin and atorvastatin were purchased from Cayman Chemical.
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PMC11742047
To analyze the trend of the QCs, identify potential outliers, and search for natural trends in the samples, a principal component analysis (PCA) was performed in SIMCA 17 Sartorius (Goettingen, Germany).
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PMC11400680
Based on the algorithms used, the methods in the literature can be divided into two categories: (I) conventional segmentation and (II) deep learning-based segmentation methods.
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PMC10919056
In the TCGA database, differential expression of GJB1 in tumor tissues and paired normal tissues. (
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PMC9429973
PreTx TB was lower in SOC patients with ongoing response vs nonresponders and patients who relapsed (P=.07), but not in axi-cel patients (P=.99).
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PMC10926885
The location, nature and degree of DNA methylation of NDE1 gene changes may be examined using the cBioPortal platform and the UALCAN web portal.
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PMC11461833
qRT-PCR revealed that the level of STXBP5 was increased in HEK293 cells overexpressing HA-progerin + FLAG-STXBP5, Over-vector-FLAG was transfected into HA-progerin-expressing HEK293 cells as the control OE condition. (
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PMC11701801
Through our previous investigation of downstream factors influencing synthetic lethality from simultaneous inhibition of CBP/p300 in SMARCB1-deficient cells, we discovered that the KREMEN2 gene was uniquely upregulated in SMARCB1-deficient cells (19).
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PMC9856122
A BBI alkaloid cepharanthrine (CEP) was the second-highest alkaloid exhibiting a −106.74 kcal/mol binding score after homorringtonine.
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PMC11026382
The marginal distribution of epistatic effects is shown along each axis.
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PMC10936243
Questions were given in English (but respondents could answer either in English or Bahasa Malaysia [Malay]) and SSZ was able to communicate in both languages which minimised the risk of misunderstandings.
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PMC9429973
Z. Mitrovic, J. Batinic, D. Radic Kristo, I. Krecak, H. Holik, V. Perisa, T. Valkovic, H. Matijaca, M. Pirsic, S. Basic Kinda, I. Aurer Departmenf of Medicine, University Hospital Dubrava; School of Medicine University of Zagreb; Departmenf of Medicine, University Hospital Center Zagreb; Departmenf of Medicine, University Hospital Merkur, Zagreb; Departmenf of Medicine, General Hospital Sibenik, Sibenik; Departmenf of Medicine, General Hospital dr.
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PMC9429973
Moreover, we noticed that in iD cohort only contaminant GFP-ve PDX cells take over in vivo despite purification by FACS sorting of transduced cells.
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PMC9429973
The most significant changes were observed at the local area for I445S, F508C, and T993R characterized by shift of molecular bonds and alteration of protein stability parameters.
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PMC11703992
For the investigation of the cell differentiation and apoptosis of Jurkat cells, staining solutions CD45-FITC (ThermoFisher, MHCD0429) and Annexin V-FITC/PI (Yeasen Bio, 40302ES) were adopted and operated according to the protocol of manufacturer.
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PMC11666785
The raw data along with reconstructed images can be found in Supplementary Videos 5 and 6.
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PMC9429973
Most of the participants (64%) had a neutral attitude towards COVID-19 vaccination.
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PMC11787381
Time of sampling: 1 h post-dosing.
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PMC11721064
Our previous research demonstrated that the limbal niche (LN) effectively promotes corneal epithelial cell transdifferentiation from OMECs within 14 days .
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PMC10547921
In ispinesib, the two aromatic substituents p-toluene and benzyl are stacked on top of each other, stabilizing the skeleton with Glu118, Arg119 and further stacking of Arg119, Trp127 and Asp130 side chains.
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PMC7685376
Huaier treatment was closely associated with the activation and inhibition of cancer-related pathways, and the MCM family was identified as a potential target in the antitumor process of Huaier.
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PMC5173112
Number of spheres formed in 786-O and A-704 cells treated with 100 ng/ml IL-8. (
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PMC5941560
MSigDB gene sets with fewer than 50 genes were not considered.
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PMC8864075
Three active ingredients and 65 related targets of reTFAE were integrated from TCMSP, BATMAN-TAM, STP, and Pubchem databases.
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PMC11734514
The summarized pathway mechanisms for C. aerizusa extract (CAe) in various signaling pathways used in this research on A549 cells.
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PMC11627398
Evidence have shown that the dysregulation of copper homeostasis is associated with multiple diseases including neurological disorders , cardiovascular diseases , cancers and sepsis .
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PMC11544122
Consistent with this hypothesis, a phosphopeptide derived from the CT in which the proximal phospho-cluster is phosphorylated or substituted with negatively charged amino acids shows higher affinity binding to SNX9 when compared with unphosphorylated peptide (Fig. 6d, e and Supplementary Table 1).
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PMC9429973
Therefore, NX-1607 may be effective as a single agent or it may significantly enhance efficacy of other anti-tumor agents in a subset of hematologic malignancies.
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PMC11706491
CRIB signal at cell tips was measured as described in .
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PMC9065483
In fact, retaining NF-κB nuclear availability allows vanadate to directly upregulate the secretion of proinflammatory cytokines to ultimately increase immune cell infiltration to the tumor site, a unique feature of vanadium compounds.
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PMC7553912
Data are expressed as mean ± SEM; n = 5–7 per group. *
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PMC9268183
In addition, four frequently cultivated vegetables (Allium cepa and Daucus carota subsp.
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PMC11472639
indicates a significant difference from post-exercise at p < 0.05.
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PMC11783017
The ATP content in the PGP group was similar to that in the Control group, while the ATP content in the tumors of the Cis/Mn/NH@PGP group increased by 4.8-fold (Fig. S29).
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PMC11461874
In this study, we demonstrated that DBP is degraded via the ubiquitin-proteasome system and that E2 enzymes UBE2G1 and UBE2T are responsible for this process.
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PMC8170755
An evidence-based report showed that an increase in the expression of CD44v6 altered the physicochemical properties of tumor cells and increased their metastatic potential (25).
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PMC11754432
After neutralisation and purification using solid phase extraction, oxylipins were quantified by LC-MS/MS as described .
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PMC8806312
CIBERSORT provides an abundance ratio estimate using gene expression data of numerous cell types in a mixed cell population .
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PMC11419566
Conventional drugs and radiotherapy are the standard treatments for cancer.
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PMC11380454
SAS alone did not affect cell viability (Fig. 7B and Fig. 8B).
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