OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC8584666	CD29 (also known as integrin β1), which is an adhesion marker for epithelial cells, was detected using APC-conjugated anti-CD29 antibody as pink color.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CD29", "(", "also", "known", "as", "integrin", "β1", ")", ",", "which", "is", "an", "adhesion", "marker", "for", "epithelial", "cells", ",", "was", "detected", "using", "APC-conjugated", "anti-CD29", "antibody", "as", "pink", "color", "." ] } ]
PMC9027909	3The expression levels of (A) occludin and (B) claudin-7 genes in the Caco-2 cell line co-incubated with B3STA, 24 h after exposure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3The", "expression", "levels", "of", "(", "A", ")", "occludin", "and", "(", "B", ")", "claudin-7", "genes", "in", "the", "Caco-2", "cell", "line", "co-incubated", "with", "B3STA", ",", "24", "h", "after", "exposure", "." ] } ]
PMC11755467	was observed—though batch dependent—upon Enoxacin treatment compared to respective DMSO control or untreated cells infected with HIV-1 (=positive control) (Figure 2a,b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "was", "observed", "—", "though", "batch", "dependent", "—", "upon", "Enoxacin", "treatment", "compared", "to", "respective", "DMSO", "control", "or", "untreated", "cells", "infected", "with", "HIV-1", "(=", "positive", "control", ")", "(", "Figure", "2a", ",", "b", ")", "." ] } ]
PMC10852540	In particular, they focused on producing some promising cytotoxic drugs originating from natural compounds such as RA, alpha lipoic acid, ascorbic acid, and curcumin17 19.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "particular", ",", "they", "focused", "on", "producing", "some", "promising", "cytotoxic", "drugs", "originating", "from", "natural", "compounds", "such", "as", "RA", ",", "alpha", "lipoic", "acid", ",", "ascorbic", "acid", ",", "and", "curcumin17", "19", "." ] } ]
PMC11001582	Sections were then incubated with primary antibodies in blocking solution overnight at 4 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sections", "were", "then", "incubated", "with", "primary", "antibodies", "in", "blocking", "solution", "overnight", "at", "4", "°", "C", "." ] } ]
PMC11521786	As part of the study of the polyclonal response triggered by the vaccine candidate, IgG subclasses in the HER3-specific PAbs induced in vaccinated mice were examined (see Supplementary Figure S2 ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "part", "of", "the", "study", "of", "the", "polyclonal", "response", "triggered", "by", "the", "vaccine", "candidate", ",", "IgG", "subclasses", "in", "the", "HER3-specific", "PAbs", "induced", "in", "vaccinated", "mice", "were", "examined", "(", "see", "Supplementary", "Figure", "S2", ")", "." ] } ]
PMC7812570	We next focused on characterizing whether GPI-m36.4 is capable of protecting human CD4 T cells from HIV-1 infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "next", "focused", "on", "characterizing", "whether", "GPI-m36.4", "is", "capable", "of", "protecting", "human", "CD4", "T", "cells", "from", "HIV-1", "infection", "." ] } ]
PMC11568601	IHC analysis was implemented to assess the expressions of p-IRE1, CHOP and cleaved caspase-3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IHC", "analysis", "was", "implemented", "to", "assess", "the", "expressions", "of", "p-IRE1", ",", "CHOP", "and", "cleaved", "caspase-3", "." ] } ]
PMC11188874	Cells were washed twice with fresh buffer, resuspended with T-cell medium, and counted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "washed", "twice", "with", "fresh", "buffer", ",", "resuspended", "with", "T-cell", "medium", ",", "and", "counted", "." ] } ]
PMC9429973	Methods: In the Hematology Department of N.N. Blokhin National Medical Research Center of Oncology (Russia, Moscow) 5 pts were treated with InO between September 2021 and February 2022.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "In", "the", "Hematology", "Department", "of", "N.N.", "Blokhin", "National", "Medical", "Research", "Center", "of", "Oncology", "(", "Russia", ",", "Moscow", ")", "5", "pts", "were", "treated", "with", "InO", "between", "September", "2021", "and", "February", "2022", "." ] } ]
PMC11025866	Expression of many fewer genes were altered by VPM compared to VPA (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "of", "many", "fewer", "genes", "were", "altered", "by", "VPM", "compared", "to", "VPA", "(", "Table", "2", ")", "." ] } ]
PMC8524093	In the present review, we outline the major points of CHIKV epidemiology, replication, and pathogenesis and also address the current in vitro and in vivo state-of-the-art experimental models of chikungunya.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "present", "review", ",", "we", "outline", "the", "major", "points", "of", "CHIKV", "epidemiology", ",", "replication", ",", "and", "pathogenesis", "and", "also", "address", "the", "current", "in", "vitro", "and", "in", "vivo", "state-of-the-art", "experimental", "models", "of", "chikungunya", "." ] } ]
PMC11228511	Experimental groups were analyzed by unpaired two-tailed Student’s t test or one-way and two-way ANOVA with Tukey’s multiple comparisons test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Experimental", "groups", "were", "analyzed", "by", "unpaired", "two-tailed", "Student", "’s", "t", "test", "or", "one-way", "and", "two-way", "ANOVA", "with", "Tukey", "’s", "multiple", "comparisons", "test", "." ] } ]
PMC11730320	D CXCR5 is selectively expressed by a subset of the Vδ1+ and Vδ1-Vδ2- γδ T cell populations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "CXCR5", "is", "selectively", "expressed", "by", "a", "subset", "of", "the", "Vδ1", "+", "and", "Vδ1-Vδ2-", "γδ", "T", "cell", "populations", "." ] } ]
PMC10898159	ACK1 inhibitor AIM-100 or ACK1 siRNA inhibits ACK1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ACK1", "inhibitor", "AIM-100", "or", "ACK1", "siRNA", "inhibits", "ACK1", "." ] } ]
PMC6600592	Then, HepG2.2.15 cell was plated at a density of 1 × 10 cells/mL in 96-well plates and incubated at 37 °C for 24 h and then treated with variant concentration of compounds in 300, 150, 75, and 35.5 μM/mL; every three days, in a nine day period, C (OD) values were recorded at 450 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "HepG2.2.15", "cell", "was", "plated", "at", "a", "density", "of", "1", "×", "10", "cells/mL", "in", "96-well", "plates", "and", "incubated", "at", "37", "°", "C", "for", "24", "h", "and", "then", "treated", "with", "variant", "concentration", "of", "compounds", "in", "300", ",", "150", ",", "75", ",", "and", "35.5", "μM/mL", ";", "every", "three", "days", ",", "in", "a", "nine", "day", "period", ",", "C", "(", "OD", ")", "values", "were", "recorded", "at", "450", "nm", "." ] } ]
PMC9784246	Additionally, in a mouse model of CL brought on by L. amazonensis, an extract from the leaves of Baccharis uncinella rich in oleanolic and ursolic acids has shown a leishmanicidal effect .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "in", "a", "mouse", "model", "of", "CL", "brought", "on", "by", "L.", "amazonensis", ",", "an", "extract", "from", "the", "leaves", "of", "Baccharis", "uncinella", "rich", "in", "oleanolic", "and", "ursolic", "acids", "has", "shown", "a", "leishmanicidal", "effect", "." ] } ]
PMC11506670	The NRAS mutant Q43K, on the other hand, had no anti-apoptotic effect on NIH3T3 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "NRAS", "mutant", "Q43", "K", ",", "on", "the", "other", "hand", ",", "had", "no", "anti-apoptotic", "effect", "on", "NIH3T3", "cells", "." ] } ]
PMC10212663	Kaplan–Meier analyses revealed significantly better OS of patients with low scores than did patients with high scores (log‐rank p = 0.00625) (Figure 8(d)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kaplan", "–", "Meier", "analyses", "revealed", "significantly", "better", "OS", "of", "patients", "with", "low", "scores", "than", "did", "patients", "with", "high", "scores", "(", "log‐rank", "p", "=", "0.00625", ")", "(", "Figure", "8(d", ")", ")", "." ] } ]
PMC11055510	The results of wound healing experiments showed that the healing rate in the si-IL1RAP group was significantly lower than that in the si-nc group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "of", "wound", "healing", "experiments", "showed", "that", "the", "healing", "rate", "in", "the", "si-IL1RAP", "group", "was", "significantly", "lower", "than", "that", "in", "the", "si-nc", "group", "." ] } ]
PMC11587541	Studies have estimated that leukocyte telomeres in adult humans shorten at a rate of 24.7 base pairs per year .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Studies", "have", "estimated", "that", "leukocyte", "telomeres", "in", "adult", "humans", "shorten", "at", "a", "rate", "of", "24.7", "base", "pairs", "per", "year", "." ] } ]
PMC10237474	For single antibiotic selection, growth media with puromycin (cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "single", "antibiotic", "selection", ",", "growth", "media", "with", "puromycin", "(", "cat", "." ] } ]
PMC10024132	Blinatumomab-secreting αβ T cells were also reported to be preferable to current CD19-CAR T cell therapies in terms of limiting leukemia escape, as this technology does not induce deep and long CD19 downregulation and it shows improved long-term disease control in preclinical models .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Blinatumomab-secreting", "αβ", "T", "cells", "were", "also", "reported", "to", "be", "preferable", "to", "current", "CD19-CAR", "T", "cell", "therapies", "in", "terms", "of", "limiting", "leukemia", "escape", ",", "as", "this", "technology", "does", "not", "induce", "deep", "and", "long", "CD19", "downregulation", "and", "it", "shows", "improved", "long-term", "disease", "control", "in", "preclinical", "models", "." ] } ]
PMC11674441	Illumina index sequences with barcodes were incorporated using the Nextera XT Index Kit (Illumina, San Diego, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Illumina", "index", "sequences", "with", "barcodes", "were", "incorporated", "using", "the", "Nextera", "XT", "Index", "Kit", "(", "Illumina", ",", "San", "Diego", ",", "CA", ",", "USA", ")", "." ] } ]
PMC10674574	Therefore, the concentrations of the substances in the range of 10–500 µM seem appropriate to assess their cytotoxicity on the Caco-2 line to conduct further in vitro permeability studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "the", "concentrations", "of", "the", "substances", "in", "the", "range", "of", "10–500", "µM", "seem", "appropriate", "to", "assess", "their", "cytotoxicity", "on", "the", "Caco-2", "line", "to", "conduct", "further", "in", "vitro", "permeability", "studies", "." ] } ]
PMC9118379	The 1123 variant protein sequences were generated by integrating exactly one variant into its wild-type protein sequence, i.e., the 1123 variants yielded 1123 variant protein sequences.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "1123", "variant", "protein", "sequences", "were", "generated", "by", "integrating", "exactly", "one", "variant", "into", "its", "wild-type", "protein", "sequence", ",", "i.e.", ",", "the", "1123", "variants", "yielded", "1123", "variant", "protein", "sequences", "." ] } ]
PMC11697703	We used miRanda, Targetscan, DIANALAB, and miRDB to search for predicted miRNA targets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "used", "miRanda", ",", "Targetscan", ",", "DIANALAB", ",", "and", "miRDB", "to", "search", "for", "predicted", "miRNA", "targets", "." ] } ]
PMC9681981	The expression ratio between each test sample and the calibrator one was estimated using the 2 formula, based on the method proposed by Pfaffl et al. (2002) ▶.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "ratio", "between", "each", "test", "sample", "and", "the", "calibrator", "one", "was", "estimated", "using", "the", "2", "formula", ",", "based", "on", "the", "method", "proposed", "by", "Pfaffl", "et", "al.", "(", "2002", ")", "▶", "." ] } ]
PMC11248911	All experiments were conducted thrice in triplicate (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "experiments", "were", "conducted", "thrice", "in", "triplicate", "(", "n", "=", "3", ")", "." ] } ]
PMC11545737	Levels of pore-forming GSDME-N have been correlated to tissue inflammation and intestinal barrier integrity in patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Levels", "of", "pore-forming", "GSDME-N", "have", "been", "correlated", "to", "tissue", "inflammation", "and", "intestinal", "barrier", "integrity", "in", "patients", "." ] } ]
PMC3203927	The expression data is publicly available on the GEO site as Series GSE13715.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "data", "is", "publicly", "available", "on", "the", "GEO", "site", "as", "Series", "GSE13715", "." ] } ]
PMC10317042	D and E, SU-CCS1 and Hewga-CCS cells were engrafted in nude mice, which were treated with 50 mg/kg vorinostat or vehicle via intraperitoneal administration (5 mice/group).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "and", "E", ",", "SU-CCS1", "and", "Hewga-CCS", "cells", "were", "engrafted", "in", "nude", "mice", ",", "which", "were", "treated", "with", "50", "mg/kg", "vorinostat", "or", "vehicle", "via", "intraperitoneal", "administration", "(", "5", "mice/group", ")", "." ] } ]
PMC5925824	Panels d and e: Gene expression analysis of cell lysate (E) and cytokine level analysis of cell culture supernatant (F) from the mixed leukocyte reactions using QuantiGene Plex and microbead-based immunoassay panels, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Panels", "d", "and", "e", ":", "Gene", "expression", "analysis", "of", "cell", "lysate", "(", "E", ")", "and", "cytokine", "level", "analysis", "of", "cell", "culture", "supernatant", "(", "F", ")", "from", "the", "mixed", "leukocyte", "reactions", "using", "QuantiGene", "Plex", "and", "microbead-based", "immunoassay", "panels", ",", "respectively", "." ] } ]
PMC10743717	This was the subject of a JBC report and thereafter dozens of ABAD reports have appeared in various journals until the present time .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "was", "the", "subject", "of", "a", "JBC", "report", "and", "thereafter", "dozens", "of", "ABAD", "reports", "have", "appeared", "in", "various", "journals", "until", "the", "present", "time", "." ] } ]
PMC11306331	However, condensate dissolution was variable across this broader set of proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "condensate", "dissolution", "was", "variable", "across", "this", "broader", "set", "of", "proteins", "." ] } ]
PMC11640476	Intermediate dilutions (440 µM in 1× PBS) were prepared, sterilized using a 0.22 µm filter, and stored at −20 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Intermediate", "dilutions", "(", "440", "µM", "in", "1", "×", "PBS", ")", "were", "prepared", ",", "sterilized", "using", "a", "0.22", "µm", "filter", ",", "and", "stored", "at", "−20", "°", "C", "." ] } ]
PMC11222184	Many chemically diverse HSP90 inhibitors have been shown in various studies to exhibit anticancer activity [5–8].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", "chemically", "diverse", "HSP90", "inhibitors", "have", "been", "shown", "in", "various", "studies", "to", "exhibit", "anticancer", "activity", "[", "5–8", "]", "." ] } ]
PMC11607638	SK and SKR in A. aegypti were found to be highly expressed in the head but only moderately in other tissues (such as thorax, salivary gland, cuticle) (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SK", "and", "SKR", "in", "A.", "aegypti", "were", "found", "to", "be", "highly", "expressed", "in", "the", "head", "but", "only", "moderately", "in", "other", "tissues", "(", "such", "as", "thorax", ",", "salivary", "gland", ",", "cuticle", ")", "(", "Figure", "1", ")", "." ] } ]
PMC9429973	Pts received optional bridging chemotherapy and fludarabine/cyclophosphamide or cytarabine/etoposide for lymphodepletion prior to a single intravenous injection of tisagenlecleucel (target dose range, 0.2-5x10/kg bodyweight [pts ≤50 kg] or 0.1-2.5x10 [pts >50 kg] CAR+ viable T cells).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pts", "received", "optional", "bridging", "chemotherapy", "and", "fludarabine/cyclophosphamide", "or", "cytarabine/etoposide", "for", "lymphodepletion", "prior", "to", "a", "single", "intravenous", "injection", "of", "tisagenlecleucel", "(", "target", "dose", "range", ",", "0.2", "-", "5x10/kg", "bodyweight", "[", "pts", "≤50", "kg", "]", "or", "0.1", "-", "2.5x10", "[", "pts", ">", "50", "kg", "]", "CAR+", "viable", "T", "cells", ")", "." ] } ]
PMC11585565	CNNM4 mRNA and protein expression were measured using RT-qPCR and Western blot analysis, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CNNM4", "mRNA", "and", "protein", "expression", "were", "measured", "using", "RT-qPCR", "and", "Western", "blot", "analysis", ",", "respectively", "." ] } ]
PMC11265931	Determining the chemical content of the plants also enables the determination of the disease or application in which this plant will be used (Zhang et al., 2020; Dad et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Determining", "the", "chemical", "content", "of", "the", "plants", "also", "enables", "the", "determination", "of", "the", "disease", "or", "application", "in", "which", "this", "plant", "will", "be", "used", "(", "Zhang", "et", "al.", ",", "2020", ";", "Dad", "et", "al.", ",", "2021", ")", "." ] } ]
PMC9429973	We could define two populations (cut off value 10 pmol/min/x105 cells): one with higher (22±12 pmol/min/x105 cells) and on with lower (3±2 pmol/min/x105 cells) p<0.0001 levels of proton leak.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "could", "define", "two", "populations", "(", "cut", "off", "value", "10", "pmol/min/x105", "cells", "):", "one", "with", "higher", "(", "22±12", "pmol/min/x105", "cells", ")", "and", "on", "with", "lower", "(", "3±2", "pmol/min/x105", "cells", ")", "p<0.0001", "levels", "of", "proton", "leak", "." ] } ]
PMC11394730	Further supporting its role as a multifunctional agent, PTL was identified as a novel inhibitor of USP7 based on the following evidence: (a) PTL inhibited USP7-mediated hydrolysis of Ub-AMC/Ub-Rho110 and di-Ub; (b) PTL competed with the binding of the Ub-VME/Ub-PA probe to USP7; and (c) CETSA, SPR, and MS analyses revealed that PTL directly interacted with USP7 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "supporting", "its", "role", "as", "a", "multifunctional", "agent", ",", "PTL", "was", "identified", "as", "a", "novel", "inhibitor", "of", "USP7", "based", "on", "the", "following", "evidence", ":", "(", "a", ")", "PTL", "inhibited", "USP7-mediated", "hydrolysis", "of", "Ub-AMC/Ub-Rho110", "and", "di-Ub", ";", "(", "b", ")", "PTL", "competed", "with", "the", "binding", "of", "the", "Ub-VME/Ub-PA", "probe", "to", "USP7", ";", "and", "(", "c", ")", "CETSA", ",", "SPR", ",", "and", "MS", "analyses", "revealed", "that", "PTL", "directly", "interacted", "with", "USP7", "." ] } ]
PMC10297204	The mean values of the G-ratio did not show any significant differences between the control and 30E groups (p = 0.17; Figure 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mean", "values", "of", "the", "G-ratio", "did", "not", "show", "any", "significant", "differences", "between", "the", "control", "and", "30E", "groups", "(", "p", "=", "0.17", ";", "Figure", "8)", "." ] } ]
PMC9429973	The translocations t(2;12) and t(8,12) both affected gene ETV6 on chr.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "translocations", "t(2;12", ")", "and", "t(8,12", ")", "both", "affected", "gene", "ETV6", "on", "chr", "." ] } ]
PMC4277423	Fig. 2A-C show that no CCR5 expression was detected on the surface of sorted CCR5 cell populations (referring to as CCR5/CR1, CCR5/CR2 and CCR5/CR3 cells).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "2A-C", "show", "that", "no", "CCR5", "expression", "was", "detected", "on", "the", "surface", "of", "sorted", "CCR5", "cell", "populations", "(", "referring", "to", "as", "CCR5/CR1", ",", "CCR5/CR2", "and", "CCR5/CR3", "cells", ")", "." ] } ]
PMC11481779	The example used to visualise the prediction & real data is chr8, position 8 600 000–10 600 000 The architecture of HiC Diffusion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "example", "used", "to", "visualise", "the", "prediction", "&", "real", "data", "is", "chr8", ",", "position", "8", "600", "000–10", "600", "000", "The", "architecture", "of", "HiC", "Diffusion", "." ] } ]
PMC11547972	However, it elevated cdk1 (moderately) in KTCTL-26, p19 (all cell lines), and Bax (all cell lines).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "it", "elevated", "cdk1", "(", "moderately", ")", "in", "KTCTL-26", ",", "p19", "(", "all", "cell", "lines", ")", ",", "and", "Bax", "(", "all", "cell", "lines", ")", "." ] } ]
PMC11773391	In recent decades, the incidence of MM has been increasing at a rate of 6%–7% annually, and the age of patients shows a younger trend.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "recent", "decades", ",", "the", "incidence", "of", "MM", "has", "been", "increasing", "at", "a", "rate", "of", "6%–7", "%", "annually", ",", "and", "the", "age", "of", "patients", "shows", "a", "younger", "trend", "." ] } ]
PMC10936243	From the short interviews, we discussed the meaning of ‘cost’ as well as other barriers which have been discussed in four separate themes (i.e. financial constraints including client’s economic limitations, workload and staffing factors, cleanliness and sterility in cat cages and the link between reducing stress and recognition of pain).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "From", "the", "short", "interviews", ",", "we", "discussed", "the", "meaning", "of", "‘", "cost", "’", "as", "well", "as", "other", "barriers", "which", "have", "been", "discussed", "in", "four", "separate", "themes", "(", "i.e.", "financial", "constraints", "including", "client", "’s", "economic", "limitations", ",", "workload", "and", "staffing", "factors", ",", "cleanliness", "and", "sterility", "in", "cat", "cages", "and", "the", "link", "between", "reducing", "stress", "and", "recognition", "of", "pain", ")", "." ] } ]
PMC10380508	The results showed there was no relationship between PAXcluster and age (p = 0.696).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "showed", "there", "was", "no", "relationship", "between", "PAXcluster", "and", "age", "(", "p", "=", "0.696", ")", "." ] } ]
PMC11794568	RT-qPCR (A) and WB (B) confirmed stable knockdown of CRIP1 in SK-MEL-2 and A375 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "RT-qPCR", "(", "A", ")", "and", "WB", "(", "B", ")", "confirmed", "stable", "knockdown", "of", "CRIP1", "in", "SK-MEL-2", "and", "A375", "cells", "." ] } ]
PMC11206251	After the extract was obtained, water and petroleum ether were added for extraction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "the", "extract", "was", "obtained", ",", "water", "and", "petroleum", "ether", "were", "added", "for", "extraction", "." ] } ]
PMC9985266	This expression was partially restored by the addition of 3-MA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "expression", "was", "partially", "restored", "by", "the", "addition", "of", "3-MA", "." ] } ]
PMC11568601	In recent years, increasing evidence has suggested that drugs or chemicals, such as CYT997 (Lexibulin), targeting ER stress are potential treatments for osteosarcoma [9–11].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "recent", "years", ",", "increasing", "evidence", "has", "suggested", "that", "drugs", "or", "chemicals", ",", "such", "as", "CYT997", "(", "Lexibulin", ")", ",", "targeting", "ER", "stress", "are", "potential", "treatments", "for", "osteosarcoma", "[", "9–11", "]", "." ] } ]
PMC6461034	Overview of experimentally established targets of BMS‐754807 (coral‐colored panel), afatinib (blue panel), and imatinib (green panel) with an affinity in the nanomolar range.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overview", "of", "experimentally", "established", "targets", "of", "BMS‐754807", "(", "coral‐colored", "panel", ")", ",", "afatinib", "(", "blue", "panel", ")", ",", "and", "imatinib", "(", "green", "panel", ")", "with", "an", "affinity", "in", "the", "nanomolar", "range", "." ] } ]
PMC11612794	In turn, the release of the mask also facilitates the interaction between binding region 2 of CENP-T and Mis12C (Figure S5B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "turn", ",", "the", "release", "of", "the", "mask", "also", "facilitates", "the", "interaction", "between", "binding", "region", "2", "of", "CENP-T", "and", "Mis12C", "(", "Figure", "S5B", ")", "." ] } ]
PMC11638288	This provides the first evidence of NKp46 as a specific NK cell killing receptor that directly participates in the prevention of tumor metastasis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "provides", "the", "first", "evidence", "of", "NKp46", "as", "a", "specific", "NK", "cell", "killing", "receptor", "that", "directly", "participates", "in", "the", "prevention", "of", "tumor", "metastasis", "." ] } ]
PMC10196713	The results of the present study revealed that cisplatin induced ferroptosis and that cisplatin-resistant OC cells were resistant to cisplatin-induced ferroptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "of", "the", "present", "study", "revealed", "that", "cisplatin", "induced", "ferroptosis", "and", "that", "cisplatin-resistant", "OC", "cells", "were", "resistant", "to", "cisplatin-induced", "ferroptosis", "." ] } ]
PMC10443665	The primers’ sequences of the endogenous control (GAPDH) and MDR1 genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primers", "’", "sequences", "of", "the", "endogenous", "control", "(", "GAPDH", ")", "and", "MDR1", "genes", "." ] } ]
PMC11352311	This is largely due to their capacity to inhibit cancer development by affecting cell proliferation, angiogenesis, and other biological processes within tumors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "largely", "due", "to", "their", "capacity", "to", "inhibit", "cancer", "development", "by", "affecting", "cell", "proliferation", ",", "angiogenesis", ",", "and", "other", "biological", "processes", "within", "tumors", "." ] } ]
PMC9429973	The secondary endpoint was overall response rate (ORR), ctDNA dynamics and adverse events (AE).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "secondary", "endpoint", "was", "overall", "response", "rate", "(", "ORR", ")", ",", "ctDNA", "dynamics", "and", "adverse", "events", "(", "AE", ")", "." ] } ]
PMC11394730	Piperine can function as a defense mechanism against ROS when given in a low dose in mouse and rat models.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Piperine", "can", "function", "as", "a", "defense", "mechanism", "against", "ROS", "when", "given", "in", "a", "low", "dose", "in", "mouse", "and", "rat", "models", "." ] } ]
PMC11087301	The capability of killing tumor cells, mediating antibody-dependent tumor cytotoxicity and eliciting tumor necrosis in parallel to contribution in chemoresistance and cancer proliferation have made them promising therapy targets .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "capability", "of", "killing", "tumor", "cells", ",", "mediating", "antibody-dependent", "tumor", "cytotoxicity", "and", "eliciting", "tumor", "necrosis", "in", "parallel", "to", "contribution", "in", "chemoresistance", "and", "cancer", "proliferation", "have", "made", "them", "promising", "therapy", "targets", "." ] } ]
PMC7185206	Thus, including ADAM10 and ADAM17 tissue staining may improve therapy selection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "including", "ADAM10", "and", "ADAM17", "tissue", "staining", "may", "improve", "therapy", "selection", "." ] } ]
PMC11544771	To understand how the combination treatment with CPX and PRE induces the G1/G0 cell cycle arrest in NSCLC cells, we analyzed the expression of CDKs and related regulatory proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "understand", "how", "the", "combination", "treatment", "with", "CPX", "and", "PRE", "induces", "the", "G1/G0", "cell", "cycle", "arrest", "in", "NSCLC", "cells", ",", "we", "analyzed", "the", "expression", "of", "CDKs", "and", "related", "regulatory", "proteins", "." ] } ]
PMC9436459	Mechanism studies revealed that 58 could inhibit HSV-1 adsorption and penetration, HSV-1 IE and L genes expression, viral DNA biosynthesis, and the HSV-induced nuclear factor (NF)-κB activation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mechanism", "studies", "revealed", "that", "58", "could", "inhibit", "HSV-1", "adsorption", "and", "penetration", ",", "HSV-1", "IE", "and", "L", "genes", "expression", ",", "viral", "DNA", "biosynthesis", ",", "and", "the", "HSV-induced", "nuclear", "factor", "(NF)-κB", "activation", "." ] } ]
PMC11155445	The antioxidant activity of the acyl thiourea ligand was strictly dose-dependent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "antioxidant", "activity", "of", "the", "acyl", "thiourea", "ligand", "was", "strictly", "dose-dependent", "." ] } ]
PMC11589157	Total RNA was isolated using a RNeasy Mini Kit (Qiagen 74104, Qiagen, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "RNA", "was", "isolated", "using", "a", "RNeasy", "Mini", "Kit", "(", "Qiagen", "74104", ",", "Qiagen", ",", "Germany", ")", "." ] } ]
PMC10158546	To verify PRNP KO, ReN cell genomic DNA was purified using QIAamp DNA Mini Kit (cat no. 51304, Qiagen, Valencia, CA, USA), and 50 ng of genomic DNA were amplified with the Q5 Hot Start High-Fidelity 2× PCR Master Mix (cat no. M0494L, NEB) using primers 5’-TCTTTGTGACTATGTGGACTG-3’ and 5’-TGCCACATGCTTGAGGTTGGTT-3’.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "verify", "PRNP", "KO", ",", "ReN", "cell", "genomic", "DNA", "was", "purified", "using", "QIAamp", "DNA", "Mini", "Kit", "(", "cat", "no.", "51304", ",", "Qiagen", ",", "Valencia", ",", "CA", ",", "USA", ")", ",", "and", "50", "ng", "of", "genomic", "DNA", "were", "amplified", "with", "the", "Q5", "Hot", "Start", "High-Fidelity", "2", "×", "PCR", "Master", "Mix", "(", "cat", "no.", "M0494L", ",", "NEB", ")", "using", "primers", "5’-TCTTTGTGACTATGTGGACTG-3", "’", "and", "5’-TGCCACATGCTTGAGGTTGGTT-3", "’", "." ] } ]
PMC9429973	With a median follow-up of 27 months, 6 of the 8 patients are alive.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "a", "median", "follow-up", "of", "27", "months", ",", "6", "of", "the", "8", "patients", "are", "alive", "." ] } ]
PMC11541409	It is particularly useful for mutations involving the cytosolic JM domain (exon 11) and/or the ATP-binding site (exon 13/14) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "particularly", "useful", "for", "mutations", "involving", "the", "cytosolic", "JM", "domain", "(", "exon", "11", ")", "and/or", "the", "ATP-binding", "site", "(", "exon", "13/14", ")", "." ] } ]
PMC11703992	Total RNA was extracted using the RNA isolation kit (Vazyme, R711-2), and reverse transcription was performed using the HiScript III RT SuperMix for qPCR (+ gDNA wiper) kit (Vazyme, R211-01).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Total", "RNA", "was", "extracted", "using", "the", "RNA", "isolation", "kit", "(", "Vazyme", ",", "R711", "-", "2", ")", ",", "and", "reverse", "transcription", "was", "performed", "using", "the", "HiScript", "III", "RT", "SuperMix", "for", "qPCR", "(", "+", "gDNA", "wiper", ")", "kit", "(", "Vazyme", ",", "R211", "-", "01", ")", "." ] } ]
PMC11291697	All investigated amino acids were detected in a single run of 60 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "investigated", "amino", "acids", "were", "detected", "in", "a", "single", "run", "of", "60", "min", "." ] } ]
PMC11089031	The Chip-seq and qPCR data showed that ZNF692 may target G3BP2 and TM9SF2 to function in ccRCC cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Chip-seq", "and", "qPCR", "data", "showed", "that", "ZNF692", "may", "target", "G3BP2", "and", "TM9SF2", "to", "function", "in", "ccRCC", "cell", "." ] } ]
PMC11055323	d Representative image of EdU assay in synovial sarcoma cell line SW982 with lentiviral expression of (b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Representative", "image", "of", "EdU", "assay", "in", "synovial", "sarcoma", "cell", "line", "SW982", "with", "lentiviral", "expression", "of", "(", "b", ")", "." ] } ]
PMC11470381	The centroids (XC, YC) of the cell ROI at subsequent time frames (Tj-1 and Tj) are used to calculate the cell displacement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "centroids", "(", "XC", ",", "YC", ")", "of", "the", "cell", "ROI", "at", "subsequent", "time", "frames", "(", "Tj-1", "and", "Tj", ")", "are", "used", "to", "calculate", "the", "cell", "displacement", "." ] } ]
PMC10891340	Duck fibroblasts infected with DPV-GFP at 37°C for 1 h, and then washed with PBS for 3 times, fresh DMEM was added with different concentrations of CCCP or DMSO for 24 h. Afterward, the supernatant was collected to determine TCID50, and the plaque of DPV-GFP was observed by fluorescence microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Duck", "fibroblasts", "infected", "with", "DPV-GFP", "at", "37", "°", "C", "for", "1", "h", ",", "and", "then", "washed", "with", "PBS", "for", "3", "times", ",", "fresh", "DMEM", "was", "added", "with", "different", "concentrations", "of", "CCCP", "or", "DMSO", "for", "24", "h.", "Afterward", ",", "the", "supernatant", "was", "collected", "to", "determine", "TCID50", ",", "and", "the", "plaque", "of", "DPV-GFP", "was", "observed", "by", "fluorescence", "microscope", "." ] } ]
PMC6642070	Based on these observations, when dichloroacetate (DCA), a reagent effective in treating lactic acidosis, was co-administered, statin-induced lactate elevation and compromised exercise capacity were reverted in mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "these", "observations", ",", "when", "dichloroacetate", "(", "DCA", ")", ",", "a", "reagent", "effective", "in", "treating", "lactic", "acidosis", ",", "was", "co-administered", ",", "statin-induced", "lactate", "elevation", "and", "compromised", "exercise", "capacity", "were", "reverted", "in", "mice", "." ] } ]
PMC10890055	However, there are also great discrepancies in the cultivation protocols.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "there", "are", "also", "great", "discrepancies", "in", "the", "cultivation", "protocols", "." ] } ]
PMC11055323	Data are mean ± s.d.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "mean", "±", "s.d", ".", "," ] } ]
PMC9429973	Aims: To figure out the promising biomarkers may influence the process of CAR-T treatment of HSCT relapsed patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "figure", "out", "the", "promising", "biomarkers", "may", "influence", "the", "process", "of", "CAR-T", "treatment", "of", "HSCT", "relapsed", "patients", "." ] } ]
PMC8143558	On the other hand, Gram-negative bacteria like Escherichia coli tend to be more resistant to antibacterial agents, compared to Gam-positive bacteria, because of their cell wall.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "other", "hand", ",", "Gram-negative", "bacteria", "like", "Escherichia", "coli", "tend", "to", "be", "more", "resistant", "to", "antibacterial", "agents", ",", "compared", "to", "Gam-positive", "bacteria", ",", "because", "of", "their", "cell", "wall", "." ] } ]
PMC9429973	Common viral infections often cause a leucopenia and frequently, thrombocytopenia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Common", "viral", "infections", "often", "cause", "a", "leucopenia", "and", "frequently", ",", "thrombocytopenia", "." ] } ]
PMC11680049	Lignin and other structural phenolic polymers accumulate in the cuticle and vascular system, ensuring vertical plant growth and resistance to drying and promoting water transport over long distances .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lignin", "and", "other", "structural", "phenolic", "polymers", "accumulate", "in", "the", "cuticle", "and", "vascular", "system", ",", "ensuring", "vertical", "plant", "growth", "and", "resistance", "to", "drying", "and", "promoting", "water", "transport", "over", "long", "distances", "." ] } ]
PMC9250505	Results represent the mean ± SEM of six animals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "represent", "the", "mean", "±", "SEM", "of", "six", "animals", "." ] } ]
PMC11075223	Although the application of these products may be beneficial for obtaining materials locally and addressing resource shortages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "the", "application", "of", "these", "products", "may", "be", "beneficial", "for", "obtaining", "materials", "locally", "and", "addressing", "resource", "shortages", "." ] } ]
PMC11750712	The panel includes the following antibodies: CD34 (QBend10, Leica Biosystems) for CAR T cell detection; CD3 (NCL-L-CD3565, Leica Biosystems) to detect T cells; Ki-67 (MIB-1, Leica Biosystems) to aid the distinction between healthy and proliferative malignant T cells; and spectral DAPI (Akoya Biosciences) for nuclei identification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "panel", "includes", "the", "following", "antibodies", ":", "CD34", "(", "QBend10", ",", "Leica", "Biosystems", ")", "for", "CAR", "T", "cell", "detection", ";", "CD3", "(", "NCL-L-CD3565", ",", "Leica", "Biosystems", ")", "to", "detect", "T", "cells", ";", "Ki-67", "(", "MIB-1", ",", "Leica", "Biosystems", ")", "to", "aid", "the", "distinction", "between", "healthy", "and", "proliferative", "malignant", "T", "cells", ";", "and", "spectral", "DAPI", "(", "Akoya", "Biosciences", ")", "for", "nuclei", "identification", "." ] } ]
PMC11763111	Data analysis was performed using the online LEGENDplex Qognit software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "analysis", "was", "performed", "using", "the", "online", "LEGENDplex", "Qognit", "software", "." ] } ]
PMC11634027	Protein samples were resolved on SDS PAGE gels (Bio-Rad, 456-1086) along with Precision Plus Dual Color Protein Standard (Bio-Rad, 1610394) and transferred to a nitrocellulose membrane (Bio-Rad, 170-4270) using a Trans-Blot Turbo machine (Bio-Rad).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "samples", "were", "resolved", "on", "SDS", "PAGE", "gels", "(", "Bio-Rad", ",", "456", "-", "1086", ")", "along", "with", "Precision", "Plus", "Dual", "Color", "Protein", "Standard", "(", "Bio-Rad", ",", "1610394", ")", "and", "transferred", "to", "a", "nitrocellulose", "membrane", "(", "Bio-Rad", ",", "170", "-", "4270", ")", "using", "a", "Trans-Blot", "Turbo", "machine", "(", "Bio-Rad", ")", "." ] } ]
PMC11684297	The results demonstrated high biocompatibility of the as-synthesized ZnO-NFs up to a dose of 200 µg/ml.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "demonstrated", "high", "biocompatibility", "of", "the", "as-synthesized", "ZnO-NFs", "up", "to", "a", "dose", "of", "200", "µg/ml", "." ] } ]
PMC11509224	These were isolated from the South China Sea sponge Diacarnus megaspinorhabdosa .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "were", "isolated", "from", "the", "South", "China", "Sea", "sponge", "Diacarnus", "megaspinorhabdosa", "." ] } ]
PMC10154881	Then, 1–5 × 10 cells were transplanted subcutaneously into their flanks, and rMV‐SLAMblind was injected intratumorally when the mass became palpable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "1–5", "×", "10", "cells", "were", "transplanted", "subcutaneously", "into", "their", "flanks", ",", "and", "rMV‐SLAMblind", "was", "injected", "intratumorally", "when", "the", "mass", "became", "palpable", "." ] } ]
PMC9429973	Methods: The study was designed retrospectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "The", "study", "was", "designed", "retrospectively", "." ] } ]
PMC9545474	No toxicity was observed in either study for either compound.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "toxicity", "was", "observed", "in", "either", "study", "for", "either", "compound", "." ] } ]
PMC11803149	Data are representative of 2 independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "representative", "of", "2", "independent", "experiments", "." ] } ]
PMC11012012	Using single-cell RNA sequencing (scRNA-seq) and mass cytometry (CyTOF), Shi et al. (2022) identified a diagnostic biomarker panel comprising 12 biomarkers, including SLAMF5/CD84, that were overexpressed in 18 patients with relapsed/refractory DLBCL versus 5 healthy volunteers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "single-cell", "RNA", "sequencing", "(", "scRNA-seq", ")", "and", "mass", "cytometry", "(", "CyTOF", ")", ",", "Shi", "et", "al.", "(", "2022", ")", "identified", "a", "diagnostic", "biomarker", "panel", "comprising", "12", "biomarkers", ",", "including", "SLAMF5/CD84", ",", "that", "were", "overexpressed", "in", "18", "patients", "with", "relapsed/refractory", "DLBCL", "versus", "5", "healthy", "volunteers", "." ] } ]
PMC11391695	Subsequently, soft-agar colony formation and CCK-8 assays revealed that pcDNA-ACYP2-treated SK-Hep-1 cells exhibited a substantial inhibition in both colony-forming and cellular proliferation (p < 0.05).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "soft-agar", "colony", "formation", "and", "CCK-8", "assays", "revealed", "that", "pcDNA-ACYP2-treated", "SK-Hep-1", "cells", "exhibited", "a", "substantial", "inhibition", "in", "both", "colony-forming", "and", "cellular", "proliferation", "(", "p", "<", "0.05", ")", "." ] } ]
PMC10329074	Paired plots were used to count the differential expression of YBX3 in ccRCC samples and matched paracancerous samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Paired", "plots", "were", "used", "to", "count", "the", "differential", "expression", "of", "YBX3", "in", "ccRCC", "samples", "and", "matched", "paracancerous", "samples", "." ] } ]
PMC9844987	The weak expression correlation between decomposed promoters of low variable promoters demonstrates that decomposed promoters may operate independently of each other, while negatively correlated pairs indicate a competition for the transcriptional machinery or a compensatory shift between decomposed promoters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "weak", "expression", "correlation", "between", "decomposed", "promoters", "of", "low", "variable", "promoters", "demonstrates", "that", "decomposed", "promoters", "may", "operate", "independently", "of", "each", "other", ",", "while", "negatively", "correlated", "pairs", "indicate", "a", "competition", "for", "the", "transcriptional", "machinery", "or", "a", "compensatory", "shift", "between", "decomposed", "promoters", "." ] } ]

PMC8584666

CD29 (also known as integrin β1), which is an adhesion marker for epithelial cells, was detected using APC-conjugated anti-CD29 antibody as pink color.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CD29", "(", "also", "known", "as", "integrin", "β1", ")", ",", "which", "is", "an", "adhesion", "marker", "for", "epithelial", "cells", ",", "was", "detected", "using", "APC-conjugated", "anti-CD29", "antibody", "as", "pink", "color", "." ] } ]

PMC9027909

3The expression levels of (A) occludin and (B) claudin-7 genes in the Caco-2 cell line co-incubated with B3STA, 24 h after exposure.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3The", "expression", "levels", "of", "(", "A", ")", "occludin", "and", "(", "B", ")", "claudin-7", "genes", "in", "the", "Caco-2", "cell", "line", "co-incubated", "with", "B3STA", ",", "24", "h", "after", "exposure", "." ] } ]

PMC11755467

was observed—though batch dependent—upon Enoxacin treatment compared to respective DMSO control or untreated cells infected with HIV-1 (=positive control) (Figure 2a,b).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "was", "observed", "—", "though", "batch", "dependent", "—", "upon", "Enoxacin", "treatment", "compared", "to", "respective", "DMSO", "control", "or", "untreated", "cells", "infected", "with", "HIV-1", "(=", "positive", "control", ")", "(", "Figure", "2a", ",", "b", ")", "." ] } ]

PMC10852540

In particular, they focused on producing some promising cytotoxic drugs originating from natural compounds such as RA, alpha lipoic acid, ascorbic acid, and curcumin17 19.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "particular", ",", "they", "focused", "on", "producing", "some", "promising", "cytotoxic", "drugs", "originating", "from", "natural", "compounds", "such", "as", "RA", ",", "alpha", "lipoic", "acid", ",", "ascorbic", "acid", ",", "and", "curcumin17", "19", "." ] } ]

PMC11001582

Sections were then incubated with primary antibodies in blocking solution overnight at 4 °C.

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PMC11521786

As part of the study of the polyclonal response triggered by the vaccine candidate, IgG subclasses in the HER3-specific PAbs induced in vaccinated mice were examined (see Supplementary Figure S2 ).

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PMC7812570

We next focused on characterizing whether GPI-m36.4 is capable of protecting human CD4 T cells from HIV-1 infection.

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PMC11568601

IHC analysis was implemented to assess the expressions of p-IRE1, CHOP and cleaved caspase-3.

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PMC11188874

Cells were washed twice with fresh buffer, resuspended with T-cell medium, and counted.

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PMC9429973

Methods: In the Hematology Department of N.N. Blokhin National Medical Research Center of Oncology (Russia, Moscow) 5 pts were treated with InO between September 2021 and February 2022.

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PMC11025866

Expression of many fewer genes were altered by VPM compared to VPA (Table 2).

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PMC8524093

In the present review, we outline the major points of CHIKV epidemiology, replication, and pathogenesis and also address the current in vitro and in vivo state-of-the-art experimental models of chikungunya.

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PMC11228511

Experimental groups were analyzed by unpaired two-tailed Student’s t test or one-way and two-way ANOVA with Tukey’s multiple comparisons test.

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PMC11730320

D CXCR5 is selectively expressed by a subset of the Vδ1+ and Vδ1-Vδ2- γδ T cell populations.

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PMC10898159

ACK1 inhibitor AIM-100 or ACK1 siRNA inhibits ACK1.

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PMC6600592

Then, HepG2.2.15 cell was plated at a density of 1 × 10 cells/mL in 96-well plates and incubated at 37 °C for 24 h and then treated with variant concentration of compounds in 300, 150, 75, and 35.5 μM/mL; every three days, in a nine day period, C (OD) values were recorded at 450 nm.

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PMC9784246

Additionally, in a mouse model of CL brought on by L. amazonensis, an extract from the leaves of Baccharis uncinella rich in oleanolic and ursolic acids has shown a leishmanicidal effect .

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PMC11506670

The NRAS mutant Q43K, on the other hand, had no anti-apoptotic effect on NIH3T3 cells.

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PMC10212663

Kaplan–Meier analyses revealed significantly better OS of patients with low scores than did patients with high scores (log‐rank p = 0.00625) (Figure 8(d)).

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PMC11055510

The results of wound healing experiments showed that the healing rate in the si-IL1RAP group was significantly lower than that in the si-nc group.

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PMC11587541

Studies have estimated that leukocyte telomeres in adult humans shorten at a rate of 24.7 base pairs per year .

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PMC10237474

For single antibiotic selection, growth media with puromycin (cat.

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PMC10024132

Blinatumomab-secreting αβ T cells were also reported to be preferable to current CD19-CAR T cell therapies in terms of limiting leukemia escape, as this technology does not induce deep and long CD19 downregulation and it shows improved long-term disease control in preclinical models .

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PMC11674441

Illumina index sequences with barcodes were incorporated using the Nextera XT Index Kit (Illumina, San Diego, CA, USA).

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PMC10674574

Therefore, the concentrations of the substances in the range of 10–500 µM seem appropriate to assess their cytotoxicity on the Caco-2 line to conduct further in vitro permeability studies.

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PMC9118379

The 1123 variant protein sequences were generated by integrating exactly one variant into its wild-type protein sequence, i.e., the 1123 variants yielded 1123 variant protein sequences.

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PMC11697703

We used miRanda, Targetscan, DIANALAB, and miRDB to search for predicted miRNA targets.

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PMC9681981

The expression ratio between each test sample and the calibrator one was estimated using the 2 formula, based on the method proposed by Pfaffl et al. (2002) ▶.

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PMC11248911

All experiments were conducted thrice in triplicate (n = 3).

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PMC11545737

Levels of pore-forming GSDME-N have been correlated to tissue inflammation and intestinal barrier integrity in patients.

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PMC3203927

The expression data is publicly available on the GEO site as Series GSE13715.

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PMC10317042

D and E, SU-CCS1 and Hewga-CCS cells were engrafted in nude mice, which were treated with 50 mg/kg vorinostat or vehicle via intraperitoneal administration (5 mice/group).

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PMC5925824

Panels d and e: Gene expression analysis of cell lysate (E) and cytokine level analysis of cell culture supernatant (F) from the mixed leukocyte reactions using QuantiGene Plex and microbead-based immunoassay panels, respectively.

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PMC10743717

This was the subject of a JBC report and thereafter dozens of ABAD reports have appeared in various journals until the present time .

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PMC11306331

However, condensate dissolution was variable across this broader set of proteins.

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PMC11640476

Intermediate dilutions (440 µM in 1× PBS) were prepared, sterilized using a 0.22 µm filter, and stored at −20 °C.

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PMC11222184

Many chemically diverse HSP90 inhibitors have been shown in various studies to exhibit anticancer activity [5–8].

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PMC11607638

SK and SKR in A. aegypti were found to be highly expressed in the head but only moderately in other tissues (such as thorax, salivary gland, cuticle) (Figure 1).

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PMC9429973

Pts received optional bridging chemotherapy and fludarabine/cyclophosphamide or cytarabine/etoposide for lymphodepletion prior to a single intravenous injection of tisagenlecleucel (target dose range, 0.2-5x10/kg bodyweight [pts ≤50 kg] or 0.1-2.5x10 [pts >50 kg] CAR+ viable T cells).

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PMC11585565

CNNM4 mRNA and protein expression were measured using RT-qPCR and Western blot analysis, respectively.

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PMC11265931

Determining the chemical content of the plants also enables the determination of the disease or application in which this plant will be used (Zhang et al., 2020; Dad et al., 2021).

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PMC9429973

We could define two populations (cut off value 10 pmol/min/x105 cells): one with higher (22±12 pmol/min/x105 cells) and on with lower (3±2 pmol/min/x105 cells) p<0.0001 levels of proton leak.

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PMC11394730

Further supporting its role as a multifunctional agent, PTL was identified as a novel inhibitor of USP7 based on the following evidence: (a) PTL inhibited USP7-mediated hydrolysis of Ub-AMC/Ub-Rho110 and di-Ub; (b) PTL competed with the binding of the Ub-VME/Ub-PA probe to USP7; and (c) CETSA, SPR, and MS analyses revealed that PTL directly interacted with USP7 .

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PMC10297204

The mean values of the G-ratio did not show any significant differences between the control and 30E groups (p = 0.17; Figure 8).

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PMC9429973

The translocations t(2;12) and t(8,12) both affected gene ETV6 on chr.

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PMC4277423

Fig. 2A-C show that no CCR5 expression was detected on the surface of sorted CCR5 cell populations (referring to as CCR5/CR1, CCR5/CR2 and CCR5/CR3 cells).

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PMC11481779

The example used to visualise the prediction & real data is chr8, position 8 600 000–10 600 000 The architecture of HiC Diffusion.

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PMC11547972

However, it elevated cdk1 (moderately) in KTCTL-26, p19 (all cell lines), and Bax (all cell lines).

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PMC11773391

In recent decades, the incidence of MM has been increasing at a rate of 6%–7% annually, and the age of patients shows a younger trend.

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PMC10936243

From the short interviews, we discussed the meaning of ‘cost’ as well as other barriers which have been discussed in four separate themes (i.e. financial constraints including client’s economic limitations, workload and staffing factors, cleanliness and sterility in cat cages and the link between reducing stress and recognition of pain).

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PMC10380508

The results showed there was no relationship between PAXcluster and age (p = 0.696).

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PMC11794568

RT-qPCR (A) and WB (B) confirmed stable knockdown of CRIP1 in SK-MEL-2 and A375 cells.

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PMC11206251

After the extract was obtained, water and petroleum ether were added for extraction.

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PMC9985266

This expression was partially restored by the addition of 3-MA.

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PMC11568601

In recent years, increasing evidence has suggested that drugs or chemicals, such as CYT997 (Lexibulin), targeting ER stress are potential treatments for osteosarcoma [9–11].

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PMC6461034

Overview of experimentally established targets of BMS‐754807 (coral‐colored panel), afatinib (blue panel), and imatinib (green panel) with an affinity in the nanomolar range.

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PMC11612794

In turn, the release of the mask also facilitates the interaction between binding region 2 of CENP-T and Mis12C (Figure S5B).

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PMC11638288

This provides the first evidence of NKp46 as a specific NK cell killing receptor that directly participates in the prevention of tumor metastasis .

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PMC10196713

The results of the present study revealed that cisplatin induced ferroptosis and that cisplatin-resistant OC cells were resistant to cisplatin-induced ferroptosis.

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PMC10443665

The primers’ sequences of the endogenous control (GAPDH) and MDR1 genes.

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PMC11352311

This is largely due to their capacity to inhibit cancer development by affecting cell proliferation, angiogenesis, and other biological processes within tumors .

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PMC9429973

The secondary endpoint was overall response rate (ORR), ctDNA dynamics and adverse events (AE).

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PMC11394730

Piperine can function as a defense mechanism against ROS when given in a low dose in mouse and rat models.

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PMC11087301

The capability of killing tumor cells, mediating antibody-dependent tumor cytotoxicity and eliciting tumor necrosis in parallel to contribution in chemoresistance and cancer proliferation have made them promising therapy targets .

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PMC7185206

Thus, including ADAM10 and ADAM17 tissue staining may improve therapy selection.

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PMC11544771

To understand how the combination treatment with CPX and PRE induces the G1/G0 cell cycle arrest in NSCLC cells, we analyzed the expression of CDKs and related regulatory proteins.

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PMC9436459

Mechanism studies revealed that 58 could inhibit HSV-1 adsorption and penetration, HSV-1 IE and L genes expression, viral DNA biosynthesis, and the HSV-induced nuclear factor (NF)-κB activation .

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PMC11155445

The antioxidant activity of the acyl thiourea ligand was strictly dose-dependent.

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PMC11589157

Total RNA was isolated using a RNeasy Mini Kit (Qiagen 74104, Qiagen, Germany).

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PMC10158546

To verify PRNP KO, ReN cell genomic DNA was purified using QIAamp DNA Mini Kit (cat no. 51304, Qiagen, Valencia, CA, USA), and 50 ng of genomic DNA were amplified with the Q5 Hot Start High-Fidelity 2× PCR Master Mix (cat no. M0494L, NEB) using primers 5’-TCTTTGTGACTATGTGGACTG-3’ and 5’-TGCCACATGCTTGAGGTTGGTT-3’.

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PMC9429973

With a median follow-up of 27 months, 6 of the 8 patients are alive.

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PMC11541409

It is particularly useful for mutations involving the cytosolic JM domain (exon 11) and/or the ATP-binding site (exon 13/14) .

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PMC11703992

Total RNA was extracted using the RNA isolation kit (Vazyme, R711-2), and reverse transcription was performed using the HiScript III RT SuperMix for qPCR (+ gDNA wiper) kit (Vazyme, R211-01).

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PMC11291697

All investigated amino acids were detected in a single run of 60 min.

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PMC11089031

The Chip-seq and qPCR data showed that ZNF692 may target G3BP2 and TM9SF2 to function in ccRCC cell.

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PMC11055323

d Representative image of EdU assay in synovial sarcoma cell line SW982 with lentiviral expression of (b).

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PMC11470381

The centroids (XC, YC) of the cell ROI at subsequent time frames (Tj-1 and Tj) are used to calculate the cell displacement.

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PMC10891340

Duck fibroblasts infected with DPV-GFP at 37°C for 1 h, and then washed with PBS for 3 times, fresh DMEM was added with different concentrations of CCCP or DMSO for 24 h. Afterward, the supernatant was collected to determine TCID50, and the plaque of DPV-GFP was observed by fluorescence microscope.

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PMC6642070

Based on these observations, when dichloroacetate (DCA), a reagent effective in treating lactic acidosis, was co-administered, statin-induced lactate elevation and compromised exercise capacity were reverted in mice.

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PMC10890055

However, there are also great discrepancies in the cultivation protocols.

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PMC11055323

Data are mean ± s.d.,

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PMC9429973

Aims: To figure out the promising biomarkers may influence the process of CAR-T treatment of HSCT relapsed patients.

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PMC8143558

On the other hand, Gram-negative bacteria like Escherichia coli tend to be more resistant to antibacterial agents, compared to Gam-positive bacteria, because of their cell wall.

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PMC9429973

Common viral infections often cause a leucopenia and frequently, thrombocytopenia.

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PMC11680049

Lignin and other structural phenolic polymers accumulate in the cuticle and vascular system, ensuring vertical plant growth and resistance to drying and promoting water transport over long distances .

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PMC9250505

Results represent the mean ± SEM of six animals.

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PMC11075223

Although the application of these products may be beneficial for obtaining materials locally and addressing resource shortages.

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PMC11750712

The panel includes the following antibodies: CD34 (QBend10, Leica Biosystems) for CAR T cell detection; CD3 (NCL-L-CD3565, Leica Biosystems) to detect T cells; Ki-67 (MIB-1, Leica Biosystems) to aid the distinction between healthy and proliferative malignant T cells; and spectral DAPI (Akoya Biosciences) for nuclei identification.

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PMC11763111

Data analysis was performed using the online LEGENDplex Qognit software.

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PMC11634027

Protein samples were resolved on SDS PAGE gels (Bio-Rad, 456-1086) along with Precision Plus Dual Color Protein Standard (Bio-Rad, 1610394) and transferred to a nitrocellulose membrane (Bio-Rad, 170-4270) using a Trans-Blot Turbo machine (Bio-Rad).

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PMC11684297

The results demonstrated high biocompatibility of the as-synthesized ZnO-NFs up to a dose of 200 µg/ml.

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PMC11509224

These were isolated from the South China Sea sponge Diacarnus megaspinorhabdosa .

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PMC10154881

Then, 1–5 × 10 cells were transplanted subcutaneously into their flanks, and rMV‐SLAMblind was injected intratumorally when the mass became palpable.

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PMC9429973

Methods: The study was designed retrospectively.

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PMC9545474

No toxicity was observed in either study for either compound.

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PMC11803149

Data are representative of 2 independent experiments.

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PMC11012012

Using single-cell RNA sequencing (scRNA-seq) and mass cytometry (CyTOF), Shi et al. (2022) identified a diagnostic biomarker panel comprising 12 biomarkers, including SLAMF5/CD84, that were overexpressed in 18 patients with relapsed/refractory DLBCL versus 5 healthy volunteers .

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PMC11391695

Subsequently, soft-agar colony formation and CCK-8 assays revealed that pcDNA-ACYP2-treated SK-Hep-1 cells exhibited a substantial inhibition in both colony-forming and cellular proliferation (p < 0.05).

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PMC10329074

Paired plots were used to count the differential expression of YBX3 in ccRCC samples and matched paracancerous samples.

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PMC9844987

The weak expression correlation between decomposed promoters of low variable promoters demonstrates that decomposed promoters may operate independently of each other, while negatively correlated pairs indicate a competition for the transcriptional machinery or a compensatory shift between decomposed promoters.

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