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PMC9739791
To identify the most efficient flavin-based catalyst, Pt(IV) prodrug-flavin parameters TOF (turnover frequency) and TON (turnover number) were calculated for each pair by H NMR study.
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PMC9545474
Their stability in solution was investigated and found sufficient for in vitro screening, with two of the complexes being dissolved directly in the biological medium without the need of DMSO, except the (η‐p‐cymene)(PTA)Ru(Mnt) which precipitated at concentrations higher than 50 μM. The (η‐p‐cymene)(TPPTS)Ru(Mnt) (6) and (η‐p‐cymene)(PPh3)Ru(Mnt) (8) complexes were found to be of the same activity as their 16‐electron precursor against A2780 and A2780cisR ovarian and H460 non‐small‐cell lung cancer cell lines, in the very low micromolar range.
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PMC9429973
Results: Initially, AS-PCR was performed only for the most common mutations c.1441T>A and c.1442G>C, however, after NGS of the BTK gene in pts with progression during ibrutinib therapy, other options were added to the test system.
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PMC11453018
While P300/CBP is recognized as a promoter of cancer cell proliferation , its impact on ES viability remains uncertain.
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PMC9541067
Data was performed as mean ± SD of three independent experiments. (*
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PMC11394386
To further elucidate the regulatory role of HOTAIR in maintaining pathway activation, we investigated the potential transcriptional repression of PTEN, a critical phosphatase antagonist in the PI3K/AKT pathway.
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PMC11295144
The primary antibodies: anti-VGAT (1,500, 131,003, Synaptic Systems), anti-GABAAR α2 subunit (1,500, 224,103, Synaptic Systems), anti-GABAAR α4 subunit (1,200, Hörtnagl et al., 2013), anti-GABAAR β2/3 subunit (1,500, MAB341, Sigma Aldrich), anti-GABAAR γ2 subunit (1,2,500, Fritschy and Mohler, 1995), anti-GABAAR δ subunit (1,200, 868-GDN, PhosphoSolutions), and anti-Bassoon (1,500, MA1-20689, Thermo Fischer) were diluted in 1% BSA in PBS, added to the cells, and incubated for 2 h at room temperature or overnight at 4°C.
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PMC11633763
The aforementioned research suggests that HK2, a crucial molecular bridge for the transition of energy metabolism and the fast proliferation of different tumour cells, is a prime candidate for osteosarcoma research.
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PMC11349530
Therefore, for therapeutic purposes, it seems that the totality of these factors (or at least some of them) should be targeted at once.
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PMC8481254
This is the first evidence that CA can reduce the proliferative capacity of cells with high glucose levels and further inhibit tumor growth by inactivating the CDK19/YAP/O-GlcNAcylation pathway, suggesting that CA is a candidate drug for the development of treatments against diabetes-associated liver cancer.
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PMC7090062
c Flow cytometric analysis was employed to determine the effect of miR-30a on the apoptosis rates in GIST cells. *
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PMC11547917
On the HCT-15 cell line, and its multidrug-resistant subline, HCT-15/CLO2, the extract exhibited potent cytotoxic activities with growth inhibition (GI50) values in the micromolar range (>10 µM) .
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PMC11693599
CD109 is secreted into the conditioned media (CM) in soluble and exosome-associated form (13).
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PMC11742431
Our platform provides a systematic approach to developing effective and practical protein degraders, offering a targeted theoretical basis and experimental support for the development of novel degradative drugs, as well as new directions for cancer therapy.
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PMC11699178
First, we analyzed characteristic genes of ovarian cancer cells using public databases such as GEO and TCGA to identify potential key genes.
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PMC11803149
Our observation of altered frequencies of Tim3-expressing cells in intra-tumoral Epas1-deficient CD8 T cells suggests that Epas1 is involved in control of the balance between Tpex and Tex cells.
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PMC9429973
Aims: We report updated data from the FUMANBA-1 study with more subjects and a longer duration of follow-up.
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PMC11699042
1Fusion-driven pediatric sarcoma cell line strains exhibit exceptional genomic, transcriptomic, and phenotypic stability compared to adult carcinoma strains.a Newly purchased A-673 EwS, HeLa cervix carcinoma and MCF-7 breast carcinoma wild type cell lines (A-673_1, HeLa_1 and MCF-7_1) were kept in culture for six months (m6; A-673_2, HeLa_2 and MCF-7_2) and twelve months (m12; A-673_3, HeLa_3 and MCF-7_3).
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PMC10218459
Cells treated with 200 µL of the full medium treated with argon for 5 s served as controls.
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PMC11697703
miRNAs can control protein availability in somata, dendrites, axons, and spines and play critical roles in fate acquisition, dendritogenesis, spinogenesis, and axon guidance.
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PMC9429973
In particular, we noticed that the rate of positivity increased with the distance from the aHSCT.
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PMC10976516
The therapeutic system, or "Trojan horse," consists of MSCs infected with OVs, which improves oncolysis and raises the acquired anti-tumor immune response, enhancing the total anticancer impact.
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PMC11674441
We used a lymph node administration method under ultrasound guidance, and the usefulness, safety, and chemical rationality of this method have been shown in a recent review .
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PMC11470999
Subsequently, we employed streptavidin‒biotin immunoprecipitation combined with high‐resolution mass spectrometry to identify PF's binding proteins by using PEG‐Biotin as the negative control.
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PMC9429973
The median number of previous treatment lines was 2 (1-5).
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PMC10671321
Pull-down assay: Myc-tagged ColQ1a WT or ColQ1a p.E428HfsX58 from transfected COS cell lysates was immobilized for 2 h on protein G magnetic beads (Dynabeads) precoated with anti-Myc antibodies.
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PMC11686380
Cells were co-transfected with pCAG-Turbo RFP together with pSuper-Luc (Control), pSuper-mGAP43#1 (KD#1), or #2 (KD#2) (1.0 µg each), and cultured for 72 h. Cells were stained with anti-GAP43.
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PMC6892818
Results are representative of at least two experiments and are presented as background-corrected relative luminescence unit (RLU) readings.
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PMC11604830
The three samples were prepared to get a final nanoparticle concentration compatible with the in vivo injected doses for the corresponding systems.
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PMC9878562
Cumulative data from three independent experiments measured in triplicates (means ± SD, Turkey’s multiple comparison ONE-WAY ANOVA ns (not significant), p≥0.05, ****p ≤ 0.0001). (
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PMC11594074
The four best-performing compounds were selected for further molecular docking studies using Molecular Operating Environment (MOE) software version 2022.02 by the Chemical Computing Group (https://www.chemcomp.com, accessed on 4 July 2024).
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PMC11585254
In addition to their role in internalization and signaling, the classical function of β-arrestins is to mediate GPCR desensitization (Kelly et al., 2008).
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PMC11803210
Venn diagram of genes expressed (average TPM (transcript per million) 10) in vehicle control- (DMSO) and 10 µM naringenin-treated MCF-7 cells.
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PMC11676674
Among the various Cistus species, C. monspeliensis has been found to exhibit the highest antioxidant activity .
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PMC9429973
None of the patients were active smokers or had chronic lung disease.
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PMC9429973
After induction, complete remission (CR) was achieved in 16,9% of patients; CR with incomplete hematologic recovery (Cri) in 7% and 20,9% had primary refractory disease.
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PMC7812570
To analyze the cell-surface expression of GPI-m36.4 or GPI-FluIgG03, transduced TZM-bl, 293FT, or CEMss-CCR5 cells were sequentially stained with a mouse anti-His tag antibody and a PE-conjugated goat anti-mouse IgG antibody or Alexa Fluor 647-conjugated goat anti-mouse IgG antibody (Invitrogen Life Technologies) for 60 min at 4 °C.
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PMC7602170
In mouse models, pharmacologic inhibitors of the PI3K pathway diminished tumor proliferation in tumor-bearing single-mutated KIT mice, indicating that PI3K kinase makes a major contribution to tumor cell proliferation in established GISTs .
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PMC11139449
Further research on CASP8AP2 can contribute to a better understanding of its biological functions and implications for human health and disease.
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PMC9429973
No dose-limiting toxicities have been observed to date up to the maximum dose of 60 mg of quizartinib.
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PMC8728081
Kajjali and Rasasindura medicines, if prepared as per the Ayurvedic method, reduce the chances of toxicity as they do not possess any organic or soluble mercury counterparts.
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PMC10728200
The median follow-up period was 48 (0–86) months.
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PMC11755467
The differential effects of Enoxacin and nalidixic acid may be explained by their different structures: Both molecules contain the 1,8-naphthyrid-4 on the scaffold substituted in 3-position with a carboxylic acid.
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PMC11591052
Mouse myoblasts C2C12 and embryonic fibroblasts NIH/3T3 were purchased from ATCC.
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PMC9429973
Survival and progression to AML was calculated using Kaplan-Meier-plots.
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PMC11634027
A-C) Wing discs of hs-Flp; ds FRT40A/arm-lacZ FRT40A; Dachs:GFP/+ (A), hs-Flp; ds FRT40A/arm-lacZ FRT40A; Dachs:GFP/+ (B), or hs-Flp; ds FRT40A/arm-lacZ FRT40A; Dachs:GFP/+ (C), with mitotic clones homozygous for ds, ds, or ds, marked by loss of β-galactosidase (red), outlined with white dashes, to show effects on Dachs:GFP (green). (
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PMC11401358
Flow cytometry detection of ROS levels in untreated and (GAGSGA)2-treated NIH 3T3 cells incubated with H2O2. (
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PMC6771295
Error bars represent standard error of means.
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PMC9429973
Cohen’s kappa test was used to assess concordance between MS and NGS samples.
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PMC9429973
Methods: Human and murine cell lines and primary murine bone barrow progenitor cells are lentivirally-transduced to induce the expression of DUX4-r alone or in combination with iD, and the effects on proliferation, transformation, and B lymphoid differentiation potential are being evaluated.
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PMC7642379
The HEK293 cell line was originally immortalized by the random integration of viral genomic DNA of adenovirus 5, which includes the E1A and E1B genes.
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PMC6892818
6Regulation of intracellular signalling pathways and their functional role in mCD40L-mediated tumour cell apoptosis.a ACHN, 786-O and A-704 cells were treated with mCD40L for the indicated time periods (1.5, 3 and 6 h) and expression of phosphorylated-MAPKs MKK4 (p-MKK4), MKK7 (p-MKK7), JNK (p-JNK) and p38 (p-p38) was detected in controls (‘C’) vs. mCD40L-treated cells (‘mL’) by immunoblotting (40 µg protein/lane).
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PMC9429973
62 BM samples evaluated by NGF were allocated in 4 immunophenotypic groups attending to: maturation blockades, abnormal antigen expression and cross lineage markers.
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PMC11774747
Several studies reported that CAR-VST maintained their cytotoxic and cytokine-secreting capabilities over extended culture periods.
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PMC8348645
The sample was mixed gently by being inverted a few times, then centrifuged for 5 min at 12,000× g rpm at 4 °C.
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PMC9429973
In solid tumors, SMARCA4 mainly possesses tumor suppressive features.
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PMC11765879
In earlier studies, ZSC was screened for its phytoconstituents using different analytical techniques revealing its abundance with several groups of metabolites such as polyphenols, flavonoids, tannins, saponins, and alkaloids ; numerous flavonoids such as rutin, quercetin, catechin, apigenin, and naringenin had been identified, and quantified from different extracts of ZSC .
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PMC9429973
Peer to peer support has shown great promise in hematologic patients, and there is a need to investigate psychosocial interventions such as peer to peer support in family caregivers.
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PMC11718109
Most interestingly, CLEM of cells co-expressing synaptophysin, synapsin and VMAT2 revealed that the two phases detectable by fluorescence correlated with two classes of vesicles: small SV-like vesicles in the synaptophysin phase and larger vesicles in the VMAT2 phase (Fig. 5K).
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PMC8740518
Another significantly altered lipid was glycerol.
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PMC10994876
Overall, the findings of this study exemplify the potential of utilizing YAP5SA to impact particular cellular mechanisms, thereby presenting an avenue for customizing cells to fulfill production demands. •
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PMC11674441
This result is consistent with another study that showed that CD4-positive T-cell responses were more strongly induced than CD8-positive T-cell responses when mRNA vaccines targeting both HLA class I-restricted neoantigens and HLA class II-restricted neoantigens were administered in melanoma patients .
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PMC11216402
In the COL1A1 locus, COL1A1_E1 and COL1A1_E2 are putative distal enhancers with increased ATAC-seq signal in Mes-like GC cell lines and TCGA-STAD relative to Epi-like and normal stomach, consistent with higher COL1A1 expression in Mes-like GC cell lines and TCGA STAD.
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PMC11087766
For protein expression, the agarose pad was supplemented with 0.2 mM IPTG (pDSW206) and/or 25 nM aTc (p15A-CmR).
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PMC5941560
Furthermore, each tool differed in the sizes of variants that it called (Additional file 1: Figures S2-S8).
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PMC9429973
The patient achieved a CR following CART2, which has been ongoing for >15 months.
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PMC11297139
The representative images supported by the relevant statistics have been chosen upon three independent preparations with similar outcomes.
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PMC11731614
The gene ontology enrichment analysis for these predicted proteins presented several interesting GO Terms.
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PMC11513011
Currently, total cystectomy, immune-check point inhibitor, antibody therapies,and chemotherapy with anticancer drugs are selected for muscular invasive cancer in Japan, but therapy is highly invasive and may cause strong side effects.
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PMC9429973
In this context, the relationship between the positivity of both surface markers and the ANKRD26, ATRX, KMT2A, MSH6, NSD1, RUNX1 and SUZ12 mutations is important.
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PMC11609529
Parental ES-2 cells were included as a control. (
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PMC11423992
MH10515, Invitrogen) for 45min at 4°C.
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PMC11300085
The Primer-BLAST software (NCBI) was used to designed primers for these genes.
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PMC11604015
However, T cell-derived malignancies are usually heterogeneous populations, leading to the rare existence of optimal antigens present in all tumor cells .
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PMC11746942
Nuclei were counterstained with DAPI (blue).
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PMC9429973
Similarly, hemoglobin stabilization remained relatively stable during the OLE, with 79% to 88% of pts achieving hemoglobin stabilization across 24-week intervals.
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PMC11700523
In addition, the 5/6 Nx group increased IS expression in the proximal, distal, and especially of injured tubules compared with the sham group, while the glomeruli were hardly stained.
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PMC6835428
Their therapeutic potential was first reported in 2001 , when it was shown that a short, double-stranded RNA duplex (about 21 nucleotide long) can induce target mRNA degradation, thus suppressing gene expression in human cells.
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PMC9429973
However, a significant difference in age at transplant was noted, with the Urban group being the eldest (median age=43) and the Abroad group being the youngest (median age=35) (P=0.011).
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PMC8316344
F, G Overexpression of TRIB2 reduced labile iron also via TFRC.
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PMC11206251
After mixing, the mixture was allowed to stand at room temperature for 10 min, and then centrifuged at 4 °C at 12,000 rpm for 10 min.
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PMC11052306
In fact, not only four but seven CuCl2 were complexed by this small dendrimer, as the C=O amide groups and the tertiary amines in the internal structure were also able to complex CuCl2 (Figure 1).
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PMC11770746
Paclitaxel (300 mg, 0.35 mmol) was stirred with disuccinylcarbonate (900 mg, 3.51 mmol) and DMAP (86 mg, 0.7 mmol) in a 40 mL 1:1 mixture of DCM & CH3CN for 3 h at room temperature.
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PMC11676169
The ability of BCAT1 to complex with KU70 and KU80 suggests that the former directly regulates the c-NHEJ repair pathway.
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PMC11224206
This may contribute to differences seen in metabolic activity between in vivo–derived and in vitro culture embryos (for example see ).
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PMC11792888
As previously shown, apoptotic cell death increased after incubation with scorpion venom (28.97 ± 4.89%) as well as etoposide (37.78 ± 6.4%) as single agents.
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PMC11594074
Cell migration and wound healing were subsequently analyzed using Image J macros version 1.54g. Using flow cytometry, the effect of compound 4 on cell cycle distribution was analyzed.
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PMC11789597
Metabolite extraction and detection, as well as metabolomics analysis, were completed by iProteome (Shanghai, China).
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PMC11144200
Numerous investigations have verified that RGD alteration on liposomes is a well-developed design scheme that can improve drug-loaded liposomes’ ability to target tumors and raise the concentration of the medication in tumors .
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PMC10938336
This methodical evaluation aimed to systematically identify and prioritize compounds with the potential for favorable druglike properties, laying the groundwork for subsequent analytical and investigatory endeavors in this study.
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PMC2614416
A DAG differs from a simple hierarchy graph in that a child (or more specialized term) may have more than one parent.
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PMC9646302
To explore the role of LAPTM5 in ccRCC, the LAPTM5 expression levels were determined in tumor and adjacent healthy tissues of patients with ccRCC obtained from TCGA database and GEO database (GSE 6344 and GSE 781).
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PMC9429973
Conversely, only 5 out of 56 IgM-MGUS patients (9%) scored CXCR4 in BM (median AF 0.65%, range: 1.1%-0.2%) and none in PB: all patients were MYD88, too.
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PMC11770199
NS versus mMSCs-p14, *P = 0.019; mMSCs-GFP versus mMSCs-p14, *P = 0.042 by one-way ANOVA with Dunnett’s multiple comparisons test (n = 6 animals). (
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PMC10743717
Such studies are also important to the elucidation of mechanisms underlying its protective activity in Parkinson’s disease .
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PMC10810426
We found that serum starvation reduced but did not completely eliminate MLV integration (3-fold reduction; Fig 1D).
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PMC3035438
Transformation was performed following a standard protocol.
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PMC11754291
In our study, significant reductions in metabolic activity were only observed at the highest blue light intensity (50 mW/cm, 50 J/cm) and under UVA exposure.
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PMC8494202
The Cancer Genome Atlas (TCGA; http://cancergenome.nih.gov/) is an internationally renowned public data platform containing large-scale genome sequencing analysis of more than 30 human tumors from mainly white and black races and has conducted large-scale genome sequencing analysis, which contains the main white and black races in the database.
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PMC11761919
The chicken hepatocellular carcinoma cell line (LMH) was cultured in DMEM medium containing 10% fetal bovine serum at 37 °C with 5% carbon dioxide (CO2).
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