OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11574029	Additionally, similar results were obtained through immunohistochemistry in our BLCA cohort (40 samples) (Fig. 1I).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "similar", "results", "were", "obtained", "through", "immunohistochemistry", "in", "our", "BLCA", "cohort", "(", "40", "samples", ")", "(", "Fig.", "1I", ")", "." ] } ]
PMC11740207	While MUSECs express similar multilineage differentiation markers to MIAMICs, they are notable due to their higher proliferative capacity (Alanazi et al., 2023).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "MUSECs", "express", "similar", "multilineage", "differentiation", "markers", "to", "MIAMICs", ",", "they", "are", "notable", "due", "to", "their", "higher", "proliferative", "capacity", "(", "Alanazi", "et", "al.", ",", "2023", ")", "." ] } ]
PMC11575040	The exclusion criteria are described as follows: belonging to a certain vulnerable population, and insufficient paraffin samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "exclusion", "criteria", "are", "described", "as", "follows", ":", "belonging", "to", "a", "certain", "vulnerable", "population", ",", "and", "insufficient", "paraffin", "samples", "." ] } ]
PMC7802142	The miRNA profiles in ReN-NV and 293-NV were detected by RNA sequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "miRNA", "profiles", "in", "ReN-NV", "and", "293-NV", "were", "detected", "by", "RNA", "sequencing", "." ] } ]
PMC11787651	These inhibitors can indirectly affect gene expression through crosstalk with DNA and histone methylation and cross-talk indirect modulation of other chromatin-associated protein activities (e.g., polycomb group and SWI–SNF [SWItch/Sucrose Non-Fermentable] complex [activity]) (62).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "inhibitors", "can", "indirectly", "affect", "gene", "expression", "through", "crosstalk", "with", "DNA", "and", "histone", "methylation", "and", "cross-talk", "indirect", "modulation", "of", "other", "chromatin-associated", "protein", "activities", "(", "e.g.", ",", "polycomb", "group", "and", "SWI", "–", "SNF", "[", "SWItch/Sucrose", "Non-Fermentable", "]", "complex", "[", "activity", "]", ")", "(", "62", ")", "." ] } ]
PMC8382973	Cytotoxicity was evaluated by calculating the cell viability = (OD450 of cell-HEC group − OD450 of blank control group)/(OD450 of HEC-free cell control group − OD450 of blank control group) × 100%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytotoxicity", "was", "evaluated", "by", "calculating", "the", "cell", "viability", "=", "(", "OD450", "of", "cell-HEC", "group", "−", "OD450", "of", "blank", "control", "group)/(OD450", "of", "HEC-free", "cell", "control", "group", "−", "OD450", "of", "blank", "control", "group", ")", "×", "100", "%", "." ] } ]
PMC11750712	Alternatively, the AUTO4 manufacturing process may have contributed to poor engraftment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Alternatively", ",", "the", "AUTO4", "manufacturing", "process", "may", "have", "contributed", "to", "poor", "engraftment", "." ] } ]
PMC11402217	This is the inaugural demonstration of apoptosis promotion through DKK1 inhibition in OS, bolstering the potential of DKK1 antagonists in OS treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "the", "inaugural", "demonstration", "of", "apoptosis", "promotion", "through", "DKK1", "inhibition", "in", "OS", ",", "bolstering", "the", "potential", "of", "DKK1", "antagonists", "in", "OS", "treatment", "." ] } ]
PMC11790971	Cell line predictions for monoclonal wells and artificial pools in different passages are shown in (g–i), (j–l), and (m–o) for passage 0, passage 1, and passage 2, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "line", "predictions", "for", "monoclonal", "wells", "and", "artificial", "pools", "in", "different", "passages", "are", "shown", "in", "(", "g", "–", "i", ")", ",", "(", "j", "–", "l", ")", ",", "and", "(", "m", "–", "o", ")", "for", "passage", "0", ",", "passage", "1", ",", "and", "passage", "2", ",", "respectively", "." ] } ]
PMC9065483	Fluorescence images were captured 24 hpi. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fluorescence", "images", "were", "captured", "24", "hpi", ".", "(" ] } ]
PMC11252553	The upper layer was composed and discarded after centrifugation (3000 rpm with monitoring room temperature for 30 min).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "upper", "layer", "was", "composed", "and", "discarded", "after", "centrifugation", "(", "3000", "rpm", "with", "monitoring", "room", "temperature", "for", "30", "min", ")", "." ] } ]
PMC8164677	It was found that the cellular accumulation of platinum for each sequence of administration was greater in the resistant cell line A2780 than the parent cell line A2780 (Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "found", "that", "the", "cellular", "accumulation", "of", "platinum", "for", "each", "sequence", "of", "administration", "was", "greater", "in", "the", "resistant", "cell", "line", "A2780", "than", "the", "parent", "cell", "line", "A2780", "(", "Figure", "4", ")", "." ] } ]
PMC10055960	Single axial site functionalization was facilitated under stoichiometric control in order to achieve binding between the pyridyl nitrogen and dirhodium core.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Single", "axial", "site", "functionalization", "was", "facilitated", "under", "stoichiometric", "control", "in", "order", "to", "achieve", "binding", "between", "the", "pyridyl", "nitrogen", "and", "dirhodium", "core", "." ] } ]
PMC10033453	In this study, we show that the chimeric virus VMG exhibited multiple modes of efficacy, including viral oncolysis and resultant cytotoxic T cell tumor infiltration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "we", "show", "that", "the", "chimeric", "virus", "VMG", "exhibited", "multiple", "modes", "of", "efficacy", ",", "including", "viral", "oncolysis", "and", "resultant", "cytotoxic", "T", "cell", "tumor", "infiltration", "." ] } ]
PMC10810426	siRNA-mediated knockdown of the indicated NUPs in NIH3T3 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "siRNA-mediated", "knockdown", "of", "the", "indicated", "NUPs", "in", "NIH3T3", "cells", "." ] } ]
PMC11519567	B Representative images of EGFP, SS18-EGFP and SS18-SSX1-EGFP fusion protein overexpressed via lentiviral infection in BJ fibroblasts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Representative", "images", "of", "EGFP", ",", "SS18-EGFP", "and", "SS18-SSX1-EGFP", "fusion", "protein", "overexpressed", "via", "lentiviral", "infection", "in", "BJ", "fibroblasts", "." ] } ]
PMC11552389	Following centrifugation, the total protein was collected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "centrifugation", ",", "the", "total", "protein", "was", "collected", "." ] } ]
PMC10956161	Moreover, the mutation frequency of the PRDX6 gene in lung adenocarcinoma ranked fourth among a range of cancers (Figure 1b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "mutation", "frequency", "of", "the", "PRDX6", "gene", "in", "lung", "adenocarcinoma", "ranked", "fourth", "among", "a", "range", "of", "cancers", "(", "Figure", "1b", ")", "." ] } ]
PMC11731614	Bonferroni adjusted p-value.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Bonferroni", "adjusted", "p-value", "." ] } ]
PMC11684269	Pyruvate dehydrogenase (PDH) is the key enzyme controlling the pyruvate flux that engages in the tricarboxylic acid (TCA) cycle.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pyruvate", "dehydrogenase", "(", "PDH", ")", "is", "the", "key", "enzyme", "controlling", "the", "pyruvate", "flux", "that", "engages", "in", "the", "tricarboxylic", "acid", "(", "TCA", ")", "cycle", "." ] } ]
PMC11361748	In (D), (F), and (H), PLA signals were quantified as the number of PLA dots per cell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "(", "D", ")", ",", "(", "F", ")", ",", "and", "(", "H", ")", ",", "PLA", "signals", "were", "quantified", "as", "the", "number", "of", "PLA", "dots", "per", "cell", "." ] } ]
PMC9429973	Repeated dosing further enhanced efficacy in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Repeated", "dosing", "further", "enhanced", "efficacy", "in", "vivo", "." ] } ]
PMC9429973	Tocilizumab was administered during CRS for this patient, and the symptom was reversed afterwards.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tocilizumab", "was", "administered", "during", "CRS", "for", "this", "patient", ",", "and", "the", "symptom", "was", "reversed", "afterwards", "." ] } ]
PMC11612794	However, even at Aurora B less-kinetochores on aligned chromosomes, Mis12C localizes at kinetochores.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "even", "at", "Aurora", "B", "less-kinetochores", "on", "aligned", "chromosomes", ",", "Mis12C", "localizes", "at", "kinetochores", "." ] } ]
PMC11794847	Next, activated Jurkat cells were cultured under designated experimental conditions and then seeded at a density of approximately 2 × 10^5 cells per well in a specialized XFp cell culture miniplate.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "activated", "Jurkat", "cells", "were", "cultured", "under", "designated", "experimental", "conditions", "and", "then", "seeded", "at", "a", "density", "of", "approximately", "2", "×", "10", "^", "5", "cells", "per", "well", "in", "a", "specialized", "XFp", "cell", "culture", "miniplate", "." ] } ]
PMC11727145	Other manners in DED preparation and standardization may have other nutrient needs for cell adhesion and migration, but with the methodology provided herein, it was notably possible to simplify and observe differences when the bottom media was replaced with burn wound exudates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "manners", "in", "DED", "preparation", "and", "standardization", "may", "have", "other", "nutrient", "needs", "for", "cell", "adhesion", "and", "migration", ",", "but", "with", "the", "methodology", "provided", "herein", ",", "it", "was", "notably", "possible", "to", "simplify", "and", "observe", "differences", "when", "the", "bottom", "media", "was", "replaced", "with", "burn", "wound", "exudates", "." ] } ]
PMC3995603	However, the efficacy of AC against atopic dermatitis (AD), an inflammatory disease, has not been examined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "efficacy", "of", "AC", "against", "atopic", "dermatitis", "(", "AD", ")", ",", "an", "inflammatory", "disease", ",", "has", "not", "been", "examined", "." ] } ]
PMC11422150	The serum NO concentration, which typically increases during inflammatory responses, was significantly suppressed in the hAMSC treatment group (Figure 5), suggesting a systemic response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "serum", "NO", "concentration", ",", "which", "typically", "increases", "during", "inflammatory", "responses", ",", "was", "significantly", "suppressed", "in", "the", "hAMSC", "treatment", "group", "(", "Figure", "5", ")", ",", "suggesting", "a", "systemic", "response", "." ] } ]
PMC11509278	Most of these studies have measured the effects of propolis harvested from different geographical regions on the growth, proliferation, and metastasis of cancer cells in vitro .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "of", "these", "studies", "have", "measured", "the", "effects", "of", "propolis", "harvested", "from", "different", "geographical", "regions", "on", "the", "growth", ",", "proliferation", ",", "and", "metastasis", "of", "cancer", "cells", "in", "vitro", "." ] } ]
PMC11672881	Still, the combination treatment exhibits a broader and more significant enrichment of apoptosis-related terms, indicating a more effective induction of apoptosis through multiple pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Still", ",", "the", "combination", "treatment", "exhibits", "a", "broader", "and", "more", "significant", "enrichment", "of", "apoptosis-related", "terms", ",", "indicating", "a", "more", "effective", "induction", "of", "apoptosis", "through", "multiple", "pathways", "." ] } ]
PMC10761218	Then, the plant material was rinsed once with sterile distilled water and weighted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "the", "plant", "material", "was", "rinsed", "once", "with", "sterile", "distilled", "water", "and", "weighted", "." ] } ]
PMC11721587	Furthermore, the preexisting mature Fu purified from the in vitro maturation experiments failed to phosphorylate Sufu-bound Ci (Fig. 5F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "preexisting", "mature", "Fu", "purified", "from", "the", "in", "vitro", "maturation", "experiments", "failed", "to", "phosphorylate", "Sufu-bound", "Ci", "(", "Fig.", "5F", ")", "." ] } ]
PMC9429973	Aims: The aim of this study is the prospective evaluation of gonadal function in young women with malignant lymphoma who are receiving CT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "The", "aim", "of", "this", "study", "is", "the", "prospective", "evaluation", "of", "gonadal", "function", "in", "young", "women", "with", "malignant", "lymphoma", "who", "are", "receiving", "CT", "." ] } ]
PMC11575040	Table S1 presents the TNM stages of these 112 patients in detail.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "S1", "presents", "the", "TNM", "stages", "of", "these", "112", "patients", "in", "detail", "." ] } ]
PMC10965680	Specifically, PDGFRB gene insertion, deletions and indels were associated with improved litter size in goats (E et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specifically", ",", "PDGFRB", "gene", "insertion", ",", "deletions", "and", "indels", "were", "associated", "with", "improved", "litter", "size", "in", "goats", "(", "E", "et", "al.", ",", "2019", ")", "." ] } ]
PMC9000591	The achieved fractional extracts were preliminarily tested for biological activities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "achieved", "fractional", "extracts", "were", "preliminarily", "tested", "for", "biological", "activities", "." ] } ]
PMC9318744	According to their prediction, the outer shell disorder of omicron is lower than that of other variants and might provide the omicron virion with a rigid outer shell that protects the virus from damage by salivary or mucosal antimicrobial enzymes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "their", "prediction", ",", "the", "outer", "shell", "disorder", "of", "omicron", "is", "lower", "than", "that", "of", "other", "variants", "and", "might", "provide", "the", "omicron", "virion", "with", "a", "rigid", "outer", "shell", "that", "protects", "the", "virus", "from", "damage", "by", "salivary", "or", "mucosal", "antimicrobial", "enzymes", "." ] } ]
PMC10758402	These results demonstrate that the combination of DMF and HSV.n212 therapy results in a greater therapeutic benefit compared to placebo or monotherapy in two different mouse models of cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "demonstrate", "that", "the", "combination", "of", "DMF", "and", "HSV.n212", "therapy", "results", "in", "a", "greater", "therapeutic", "benefit", "compared", "to", "placebo", "or", "monotherapy", "in", "two", "different", "mouse", "models", "of", "cancer", "." ] } ]
PMC11411004	According to the experimental results, the use of I-4 significantly elevated the expression of HC and LC mRNA by approximately 1.60-fold and 1.44-fold, respectively, compared with the control group without I-4 treatment (Fig. 4a, b).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "the", "experimental", "results", ",", "the", "use", "of", "I-4", "significantly", "elevated", "the", "expression", "of", "HC", "and", "LC", "mRNA", "by", "approximately", "1.60-fold", "and", "1.44-fold", ",", "respectively", ",", "compared", "with", "the", "control", "group", "without", "I-4", "treatment", "(", "Fig.", "4a", ",", "b).Fig", "." ] } ]
PMC9429973	The IL-1RN 1/3 and 1/4 genotypes were significantly more common in patients with MM compared to healthy controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IL-1RN", "1/3", "and", "1/4", "genotypes", "were", "significantly", "more", "common", "in", "patients", "with", "MM", "compared", "to", "healthy", "controls", "." ] } ]
PMC10198699	The history of the HeLa cell line raises several ethical and legal issues.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "history", "of", "the", "HeLa", "cell", "line", "raises", "several", "ethical", "and", "legal", "issues", "." ] } ]
PMC9587866	The predicted resolution of EYA3 model is 1.565 Å, which is considered good and valid for a constructed protein structure as proven by ResProX. Active Site Residues in EYA3 The active site residues were identified in order to direct the medicinal ligands toward the active pocket and inhibit the protein activity of EYA3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "predicted", "resolution", "of", "EYA3", "model", "is", "1.565", "Å", ",", "which", "is", "considered", "good", "and", "valid", "for", "a", "constructed", "protein", "structure", "as", "proven", "by", "ResProX.", "Active", "Site", "Residues", "in", "EYA3", "The", "active", "site", "residues", "were", "identified", "in", "order", "to", "direct", "the", "medicinal", "ligands", "toward", "the", "active", "pocket", "and", "inhibit", "the", "protein", "activity", "of", "EYA3", "." ] } ]
PMC10560648	In conclusion, C. Andromeda venom can cause an apoptosis increase through upregulation of p15INK4b and P53 proteins and downregulation of Bcl-2, p21 , and DNMT1 in the Jurkat cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "C.", "Andromeda", "venom", "can", "cause", "an", "apoptosis", "increase", "through", "upregulation", "of", "p15INK4b", "and", "P53", "proteins", "and", "downregulation", "of", "Bcl-2", ",", "p21", ",", "and", "DNMT1", "in", "the", "Jurkat", "cell", "line", "." ] } ]
PMC11659734	Moreover, 2D cultures may exhibit abnormal gene expression profiles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "2D", "cultures", "may", "exhibit", "abnormal", "gene", "expression", "profiles", "." ] } ]
PMC6799808	Interestingly, treatment with GLPT (0–2 mg/ml) for 24 h increased the level of cleaved caspase 8 (Fig. 3b), indicating activation of caspase 8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "treatment", "with", "GLPT", "(", "0–2", "mg/ml", ")", "for", "24", "h", "increased", "the", "level", "of", "cleaved", "caspase", "8", "(", "Fig.", "3b", ")", ",", "indicating", "activation", "of", "caspase", "8", "." ] } ]
PMC11787355	Finally, the column was re-equilibrated at 1% solvent B for 11 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "the", "column", "was", "re-equilibrated", "at", "1", "%", "solvent", "B", "for", "11", "min", "." ] } ]
PMC10366908	Using the CBIS method, we have developed mAbs against human antigens, including human epidermal growth factor receptor 2 (HER2) , human epidermal growth factor receptor 3 (HER3) , epithelial cell adhesion molecule (EpCAM) , trophoblast cell surface antigen 2 (TROP2) , programmed cell death ligand 1 (PD-L1) , podoplanin (PDPN) , the cluster of differentiation 19 (CD19) , CD20 , CD44 , CD133 , killer cell lectin-like receptor G1 (KLRG1) , C-C motif chemokine receptor 9 (CCR9) , and T cell immunoreceptor with Ig and ITIM domains (TIGIT) by the immunization of antigen-overexpressing cells in mice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "the", "CBIS", "method", ",", "we", "have", "developed", "mAbs", "against", "human", "antigens", ",", "including", "human", "epidermal", "growth", "factor", "receptor", "2", "(", "HER2", ")", ",", "human", "epidermal", "growth", "factor", "receptor", "3", "(", "HER3", ")", ",", "epithelial", "cell", "adhesion", "molecule", "(", "EpCAM", ")", ",", "trophoblast", "cell", "surface", "antigen", "2", "(", "TROP2", ")", ",", "programmed", "cell", "death", "ligand", "1", "(", "PD-L1", ")", ",", "podoplanin", "(", "PDPN", ")", ",", "the", "cluster", "of", "differentiation", "19", "(", "CD19", ")", ",", "CD20", ",", "CD44", ",", "CD133", ",", "killer", "cell", "lectin-like", "receptor", "G1", "(", "KLRG1", ")", ",", "C-C", "motif", "chemokine", "receptor", "9", "(", "CCR9", ")", ",", "and", "T", "cell", "immunoreceptor", "with", "Ig", "and", "ITIM", "domains", "(", "TIGIT", ")", "by", "the", "immunization", "of", "antigen-overexpressing", "cells", "in", "mice", "." ] } ]
PMC7642379	Genes with high impact SNVs in progeny cell lines compared to the parental HEK293 can be found in Supplementary Table S2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genes", "with", "high", "impact", "SNVs", "in", "progeny", "cell", "lines", "compared", "to", "the", "parental", "HEK293", "can", "be", "found", "in", "Supplementary", "Table", "S2", "." ] } ]
PMC9268183	Based on this, and aiming at filling such caveat, the main objectives of this study were as follows: (i) to report the potential uses of plants in cancer treatment, including preventive and palliative applications, based on the information of traditional uses recorded in CLA; (ii) to carry out a literature review of pharmacological activity and uses of plants concerned; and (iii) to prove the importance of traditional knowledge as a starting point in the development of new plant-based drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "this", ",", "and", "aiming", "at", "filling", "such", "caveat", ",", "the", "main", "objectives", "of", "this", "study", "were", "as", "follows", ":", "(", "i", ")", "to", "report", "the", "potential", "uses", "of", "plants", "in", "cancer", "treatment", ",", "including", "preventive", "and", "palliative", "applications", ",", "based", "on", "the", "information", "of", "traditional", "uses", "recorded", "in", "CLA", ";", "(", "ii", ")", "to", "carry", "out", "a", "literature", "review", "of", "pharmacological", "activity", "and", "uses", "of", "plants", "concerned", ";", "and", "(", "iii", ")", "to", "prove", "the", "importance", "of", "traditional", "knowledge", "as", "a", "starting", "point", "in", "the", "development", "of", "new", "plant-based", "drugs", "." ] } ]
PMC9429973	Four patients died due to shock with neurological involvement, respiratory failure, or multiple organic failure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Four", "patients", "died", "due", "to", "shock", "with", "neurological", "involvement", ",", "respiratory", "failure", ",", "or", "multiple", "organic", "failure", "." ] } ]
PMC11803149	CAR-T cells with a central memory cell phenotype characterized by expression of CD62L and CD44 (CD62L CD44) exhibit high anti-tumor activity (31).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CAR-T", "cells", "with", "a", "central", "memory", "cell", "phenotype", "characterized", "by", "expression", "of", "CD62L", "and", "CD44", "(", "CD62L", "CD44", ")", "exhibit", "high", "anti-tumor", "activity", "(", "31", ")", "." ] } ]
PMC11365983	To validate these findings, we next assayed the effect of manipulating Foxc1 levels using a second cell line: immortalized embryonic primary chondrocytes that express high levels of endogenous Foxc1 (Supplemental Fig. 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "validate", "these", "findings", ",", "we", "next", "assayed", "the", "effect", "of", "manipulating", "Foxc1", "levels", "using", "a", "second", "cell", "line", ":", "immortalized", "embryonic", "primary", "chondrocytes", "that", "express", "high", "levels", "of", "endogenous", "Foxc1", "(", "Supplemental", "Fig.", "3", ")", "." ] } ]
PMC11657744	Cells were serum-starved (-SM) for 24 h to induce cilia formation and then treated with 10% serum-containing media (+ SM) for indicated times.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "serum-starved", "(", "-SM", ")", "for", "24", "h", "to", "induce", "cilia", "formation", "and", "then", "treated", "with", "10", "%", "serum-containing", "media", "(", "+", "SM", ")", "for", "indicated", "times", "." ] } ]
PMC11300085	RNAiso plus reagent (Takara, Tokyo, Japan) was applied to extract the total RNA following the manufacturer's instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNAiso", "plus", "reagent", "(", "Takara", ",", "Tokyo", ",", "Japan", ")", "was", "applied", "to", "extract", "the", "total", "RNA", "following", "the", "manufacturer", "'s", "instructions", "." ] } ]
PMC11381192	Distribution of risk score and survival status between CSI risk groups. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Distribution", "of", "risk", "score", "and", "survival", "status", "between", "CSI", "risk", "groups", ".", "(" ] } ]
PMC11754784	PAGE and DLS were used to characterize the assembly of DNP1 (Supplementary Fig. 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PAGE", "and", "DLS", "were", "used", "to", "characterize", "the", "assembly", "of", "DNP1", "(", "Supplementary", "Fig.", "8)", "." ] } ]
PMC6684588	In normal resting muscle, satellite cells express factors inhibitory to myogenesis, including myostatin and activin A, whereas fibroadipogenic progenitor cells express promyogenic factors such as follistatin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "normal", "resting", "muscle", ",", "satellite", "cells", "express", "factors", "inhibitory", "to", "myogenesis", ",", "including", "myostatin", "and", "activin", "A", ",", "whereas", "fibroadipogenic", "progenitor", "cells", "express", "promyogenic", "factors", "such", "as", "follistatin", "." ] } ]
PMC11513011	Caspases are key mediators of apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Caspases", "are", "key", "mediators", "of", "apoptosis", "." ] } ]
PMC10713411	Subsequently, we comprehensively explored the influence of TRIB3 on tumor growth and development by conducting cell viability assays, assessment of cell proliferation and migration capacity and colony formation experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "we", "comprehensively", "explored", "the", "influence", "of", "TRIB3", "on", "tumor", "growth", "and", "development", "by", "conducting", "cell", "viability", "assays", ",", "assessment", "of", "cell", "proliferation", "and", "migration", "capacity", "and", "colony", "formation", "experiments", "." ] } ]
PMC11585565	Vision impairment, often starting in childhood or early adulthood, is a common symptom as retinal degeneration progresses, leading to cone-rod dystrophy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vision", "impairment", ",", "often", "starting", "in", "childhood", "or", "early", "adulthood", ",", "is", "a", "common", "symptom", "as", "retinal", "degeneration", "progresses", ",", "leading", "to", "cone-rod", "dystrophy", "." ] } ]
PMC11803918	The blood samples were collected for flow cytometry and ELISpot assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "blood", "samples", "were", "collected", "for", "flow", "cytometry", "and", "ELISpot", "assay", "." ] } ]
PMC11676169	For the purification of BCAT1-associated proteins, 1 × 10 CUTLL1 cells stably expressing myc-DDK-tagged BCAT1 (BCAT1 myc/DDK) and control CUTLL1 cells were harvested by centrifugation and washed in cold PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "purification", "of", "BCAT1-associated", "proteins", ",", "1", "×", "10", "CUTLL1", "cells", "stably", "expressing", "myc-DDK-tagged", "BCAT1", "(", "BCAT1", "myc/DDK", ")", "and", "control", "CUTLL1", "cells", "were", "harvested", "by", "centrifugation", "and", "washed", "in", "cold", "PBS", "." ] } ]
PMC11747467	P-value < 0.05; , P-value < 0.01; , P-value < 0.001; ***, P-value < 0.0001; ns, not significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P-value", "<", "0.05", ";", "", "", ",", "P-value", "<", "0.01", ";", "", "", "", ",", "P-value", "<", "0.001", ";", "", "", "", "*", ",", "P-value", "<", "0.0001", ";", "ns", ",", "not", "significant", "." ] } ]
PMC5034105	Twelve of these 14 cell lines (JEG-3, HEK, HeLa, LNCaP, SF268, RD, ARPE19, Hep-2, Calu-3, HFL, Caco-2 and Huh-7) showed obvious ZIKV-NS1 protein expression by IF in addition to a high viral load (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twelve", "of", "these", "14", "cell", "lines", "(", "JEG-3", ",", "HEK", ",", "HeLa", ",", "LNCaP", ",", "SF268", ",", "RD", ",", "ARPE19", ",", "Hep-2", ",", "Calu-3", ",", "HFL", ",", "Caco-2", "and", "Huh-7", ")", "showed", "obvious", "ZIKV-NS1", "protein", "expression", "by", "IF", "in", "addition", "to", "a", "high", "viral", "load", "(", "Table", "2", ")", "." ] } ]
PMC9065483	Further investigation into this relationship would broaden our understanding of STAT2 regulation of the IFN-1 responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "investigation", "into", "this", "relationship", "would", "broaden", "our", "understanding", "of", "STAT2", "regulation", "of", "the", "IFN-1", "responses", "." ] } ]
PMC11402217	Transfection efficiency was verified by qPCR and fluorescence microscopy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transfection", "efficiency", "was", "verified", "by", "qPCR", "and", "fluorescence", "microscopy", "." ] } ]
PMC11190238	The EMT process is crucial during the gastrulation stage of early embryo development for neural crest cells to delaminate and embark on differentiation towards their derivatives.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "EMT", "process", "is", "crucial", "during", "the", "gastrulation", "stage", "of", "early", "embryo", "development", "for", "neural", "crest", "cells", "to", "delaminate", "and", "embark", "on", "differentiation", "towards", "their", "derivatives", "." ] } ]
PMC8806312	The top 5 terms for MF were as follows: receptor ligand activity, receptor regulator activity, carbohydrate binding, steroid hormone receptor activity and cytokine receptor activity (Figure 2(a)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "top", "5", "terms", "for", "MF", "were", "as", "follows", ":", "receptor", "ligand", "activity", ",", "receptor", "regulator", "activity", ",", "carbohydrate", "binding", ",", "steroid", "hormone", "receptor", "activity", "and", "cytokine", "receptor", "activity", "(", "Figure", "2(a", ")", ")", "." ] } ]
PMC10114490	Toxicometabolomic analysis upon incubation with known active hepatic substances revealed that our diHLC-T outperform HepG2, probably due to the intense xenobiotic-related metabolic rewiring, including a general improvement of glutathione metabolic pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Toxicometabolomic", "analysis", "upon", "incubation", "with", "known", "active", "hepatic", "substances", "revealed", "that", "our", "diHLC-T", "outperform", "HepG2", ",", "probably", "due", "to", "the", "intense", "xenobiotic-related", "metabolic", "rewiring", ",", "including", "a", "general", "improvement", "of", "glutathione", "metabolic", "pathway", "." ] } ]
PMC11291490	The gating strategy was shown in Supplementary Fig. 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gating", "strategy", "was", "shown", "in", "Supplementary", "Fig.", "3", "." ] } ]
PMC11653168	The present study also demonstrated the complex interaction between apoptosis and autophagy induced by Stattic in CCRF-CEM and Jurkat cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "present", "study", "also", "demonstrated", "the", "complex", "interaction", "between", "apoptosis", "and", "autophagy", "induced", "by", "Stattic", "in", "CCRF-CEM", "and", "Jurkat", "cells", "." ] } ]
PMC11699042	Here, we hypothesize that oligomutated pediatric sarcoma cell lines mainly driven by a fusion transcription factor, such as Ewing sarcoma (EwS), are genetically and phenotypically more stable than the previously investigated adult carcinoma cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "hypothesize", "that", "oligomutated", "pediatric", "sarcoma", "cell", "lines", "mainly", "driven", "by", "a", "fusion", "transcription", "factor", ",", "such", "as", "Ewing", "sarcoma", "(", "EwS", ")", ",", "are", "genetically", "and", "phenotypically", "more", "stable", "than", "the", "previously", "investigated", "adult", "carcinoma", "cell", "lines", "." ] } ]
PMC11075223	Its structure was formed by a single glucose connecting two parts of cimifugin and FA .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Its", "structure", "was", "formed", "by", "a", "single", "glucose", "connecting", "two", "parts", "of", "cimifugin", "and", "FA", "." ] } ]
PMC11695623	Volcanic map of DCUN1D5 differential genes in TCGA-LUAD data set. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Volcanic", "map", "of", "DCUN1D5", "differential", "genes", "in", "TCGA-LUAD", "data", "set", ".", "(" ] } ]
PMC11799620	Finally, to explore its biological benefits and its protective effect against cadmium toxicity, these research investigators carried out (1) an in vitro protein glycation test, (2) MTT and inverted microscope imaging in HepG2 and HEK293 cell line, and (3) a lipid peroxidation test using rat erythrocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "to", "explore", "its", "biological", "benefits", "and", "its", "protective", "effect", "against", "cadmium", "toxicity", ",", "these", "research", "investigators", "carried", "out", "(", "1", ")", "an", "in", "vitro", "protein", "glycation", "test", ",", "(", "2", ")", "MTT", "and", "inverted", "microscope", "imaging", "in", "HepG2", "and", "HEK293", "cell", "line", ",", "and", "(", "3", ")", "a", "lipid", "peroxidation", "test", "using", "rat", "erythrocytes", "." ] } ]
PMC11756514	Binding of biotinylated mannan-binding lectin and (C) Binding of biotinylated Langerin ECD to the bacteria in either calcium or EDTA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Binding", "of", "biotinylated", "mannan-binding", "lectin", "and", "(", "C", ")", "Binding", "of", "biotinylated", "Langerin", "ECD", "to", "the", "bacteria", "in", "either", "calcium", "or", "EDTA", "." ] } ]
PMC11361748	Solving this enigma requires additional studies but is poised to yield novel clues as to how to mitigate TAR in the setting of human chronic inflammatory skin diseases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Solving", "this", "enigma", "requires", "additional", "studies", "but", "is", "poised", "to", "yield", "novel", "clues", "as", "to", "how", "to", "mitigate", "TAR", "in", "the", "setting", "of", "human", "chronic", "inflammatory", "skin", "diseases", "." ] } ]
PMC11585254	A complete list of new plasmids and construct assembly information described in this study are available in Supplemental Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "complete", "list", "of", "new", "plasmids", "and", "construct", "assembly", "information", "described", "in", "this", "study", "are", "available", "in", "Supplemental", "Table", "1", "." ] } ]
PMC11678368	A higher IC50 value for healthy cells (e.g., BALB/3T3), may indicate better selectivity of the compound, leading to a lower risk of side effects while maintaining therapeutic efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "higher", "IC50", "value", "for", "healthy", "cells", "(", "e.g.", ",", "BALB/3T3", ")", ",", "may", "indicate", "better", "selectivity", "of", "the", "compound", ",", "leading", "to", "a", "lower", "risk", "of", "side", "effects", "while", "maintaining", "therapeutic", "efficacy", "." ] } ]
PMC6163708	The most potent HH inhibitor GANT61 suppressed proliferation more or less in about half of tumor cell lines (the sensitive cells were eradicated presumably through apoptosis) and is a prime candidate as a compound for the combined therapy in many tumor types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "potent", "HH", "inhibitor", "GANT61", "suppressed", "proliferation", "more", "or", "less", "in", "about", "half", "of", "tumor", "cell", "lines", "(", "the", "sensitive", "cells", "were", "eradicated", "presumably", "through", "apoptosis", ")", "and", "is", "a", "prime", "candidate", "as", "a", "compound", "for", "the", "combined", "therapy", "in", "many", "tumor", "types", "." ] } ]
PMC11768281	These cells play a crucial role in detecting the parasite and initiating the immune response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "cells", "play", "a", "crucial", "role", "in", "detecting", "the", "parasite", "and", "initiating", "the", "immune", "response", "." ] } ]
PMC9429973	Twenty-four percent of pts had a mean hemoglobin increase ≥1.5 g/dL from BL over 12 weeks without transfusions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twenty-four", "percent", "of", "pts", "had", "a", "mean", "hemoglobin", "increase", "≥1.5", "g/dL", "from", "BL", "over", "12", "weeks", "without", "transfusions", "." ] } ]
PMC10809689	Based on diagrams (a., c.) and protein bands (b., d.), the expression of these proteins in the Gal-9 treated group compared to the control and PMA group had a significant increase at 24 h after Gal-9 treatment (PG24) (p = 0.0001) followed by a decrease at 48th hour.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "diagrams", "(", "a.", ",", "c.", ")", "and", "protein", "bands", "(", "b.", ",", "d.", ")", ",", "the", "expression", "of", "these", "proteins", "in", "the", "Gal-9", "treated", "group", "compared", "to", "the", "control", "and", "PMA", "group", "had", "a", "significant", "increase", "at", "24", "h", "after", "Gal-9", "treatment", "(", "PG24", ")", "(", "p", "=", "0.0001", ")", "followed", "by", "a", "decrease", "at", "48th", "hour", "." ] } ]
PMC9046263	p < 0.05.Figure 4HML-6 is overexpressed in several glioma cell lines compared to astrocytes (A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05.Figure", "4HML-6", "is", "overexpressed", "in", "several", "glioma", "cell", "lines", "compared", "to", "astrocytes", "(", "A", ")", "." ] } ]
PMC11021472	About 85% of human circRNAs align to known genes, with the majority being derived from protein-coding exons and a smaller proportion originating from untranslated regions (UTRs) or introns.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "About", "85", "%", "of", "human", "circRNAs", "align", "to", "known", "genes", ",", "with", "the", "majority", "being", "derived", "from", "protein-coding", "exons", "and", "a", "smaller", "proportion", "originating", "from", "untranslated", "regions", "(", "UTRs", ")", "or", "introns", "." ] } ]
PMC9429973	The average time from RUX initiation was 22.1±14.5 (6-48) months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "average", "time", "from", "RUX", "initiation", "was", "22.1±14.5", "(", "6", "-", "48", ")", "months", "." ] } ]
PMC11730311	Through attachment of lipid moieties, the acylated peptide can bind to serum albumin, which enables protection against renal excretion and enzymatic degradation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Through", "attachment", "of", "lipid", "moieties", ",", "the", "acylated", "peptide", "can", "bind", "to", "serum", "albumin", ",", "which", "enables", "protection", "against", "renal", "excretion", "and", "enzymatic", "degradation", "." ] } ]
PMC9429973	On multivariate analysis, only infection grade≥3 had statistical impact on mortality (p=0.027; HR 10.037).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "multivariate", "analysis", ",", "only", "infection", "grade≥3", "had", "statistical", "impact", "on", "mortality", "(", "p=0.027", ";", "HR", "10.037", ")", "." ] } ]
PMC7171147	The protein expression of CPT1A in normal ovaries and ovarian cancer was extracted from the Human Protein Atlas.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "expression", "of", "CPT1A", "in", "normal", "ovaries", "and", "ovarian", "cancer", "was", "extracted", "from", "the", "Human", "Protein", "Atlas", "." ] } ]
PMC8140214	Data are presented as mean±SD (n=4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "mean±SD", "(", "n=4", ")", "." ] } ]
PMC11790599	To further characterize the TSL-induced macropinosomes, we used F-actin polymerization inhibitor cytochalasin D (CytD) (Nakase et al., 2004), Rac1 inhibitor EHT1864, and the cholesterol-depleting agent Methyl-β-cyclodextrin (mβCD) (Ramirez et al., 2019) to modulate their development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "further", "characterize", "the", "TSL-induced", "macropinosomes", ",", "we", "used", "F-actin", "polymerization", "inhibitor", "cytochalasin", "D", "(", "CytD", ")", "(", "Nakase", "et", "al.", ",", "2004", ")", ",", "Rac1", "inhibitor", "EHT1864", ",", "and", "the", "cholesterol-depleting", "agent", "Methyl-β-cyclodextrin", "(", "mβCD", ")", "(", "Ramirez", "et", "al.", ",", "2019", ")", "to", "modulate", "their", "development", "." ] } ]
PMC11391695	For immunohistochemical staining, paraffin-embedded sections were performed after the tumors were fixed in 4% paraformaldehyde.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "immunohistochemical", "staining", ",", "paraffin-embedded", "sections", "were", "performed", "after", "the", "tumors", "were", "fixed", "in", "4", "%", "paraformaldehyde", "." ] } ]
PMC11045125	The EBV negative Akata BL line and a BL5 EBV infected LCL serve as controls.	[ { "tags": [ "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "EBV", "negative", "Akata", "BL", "line", "and", "a", "BL5", "EBV", "infected", "LCL", "serve", "as", "controls", "." ] } ]
PMC9429973	Our PFS analysis showed that ACA-O was the best treatment in both MU/UN-only patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "PFS", "analysis", "showed", "that", "ACA-O", "was", "the", "best", "treatment", "in", "both", "MU/UN-only", "patients", "." ] } ]
PMC6803987	Based on these data , the compound was identified as esculetin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "these", "data", ",", "the", "compound", "was", "identified", "as", "esculetin", "." ] } ]
PMC10452486	D0 plays a central role in the stronger binding of KIR3DL2 to Face-2 of HLA-F, and Face-2 and Face-4 of HLA-I classes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D0", "plays", "a", "central", "role", "in", "the", "stronger", "binding", "of", "KIR3DL2", "to", "Face-2", "of", "HLA-F", ",", "and", "Face-2", "and", "Face-4", "of", "HLA-I", "classes", "." ] } ]
PMC11782780	Single-cell suspensions were plated into a 96-well ultra-low attachment plate (1,000 cells/well) in serum-free medium containing 2% B-27 (Invitrogen), 20 ‍ng/ml EGF (MCE), 20 ‍ng/ml bFGF (Invitrogen), and 10 ‍μg/ml heparin (Sigma, St. Louis, MO).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Single-cell", "suspensions", "were", "plated", "into", "a", "96-well", "ultra-low", "attachment", "plate", "(", "1,000", "cells/well", ")", "in", "serum-free", "medium", "containing", "2", "%", "B-27", "(", "Invitrogen", ")", ",", "20", "‍ng/ml", "EGF", "(", "MCE", ")", ",", "20", "‍ng/ml", "bFGF", "(", "Invitrogen", ")", ",", "and", "10", "‍μg/ml", "heparin", "(", "Sigma", ",", "St.", "Louis", ",", "MO", ")", "." ] } ]
PMC11188874	E.G7-Ova cells constitutively synthesize Ova and are a validated model to study MHC-I–restricted CTL activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E.G7-Ova", "cells", "constitutively", "synthesize", "Ova", "and", "are", "a", "validated", "model", "to", "study", "MHC-I", "–", "restricted", "CTL", "activity", "." ] } ]
PMC9429973	Therapy focused only on treating the underlying disease in 21 patients (19%) did not lead to an increase in Hb (p> 0.05), although patients subjectively noted an improvement in well-being.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therapy", "focused", "only", "on", "treating", "the", "underlying", "disease", "in", "21", "patients", "(", "19", "%", ")", "did", "not", "lead", "to", "an", "increase", "in", "Hb", "(", "p", ">", "0.05", ")", ",", "although", "patients", "subjectively", "noted", "an", "improvement", "in", "well-being", "." ] } ]
PMC11661024	Although there is a limitation among cancer individuals with considerable immune deficiencies to intake probiotics, few studies related to their anticancer activities are available.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "there", "is", "a", "limitation", "among", "cancer", "individuals", "with", "considerable", "immune", "deficiencies", "to", "intake", "probiotics", ",", "few", "studies", "related", "to", "their", "anticancer", "activities", "are", "available", "." ] } ]

PMC11574029

Additionally, similar results were obtained through immunohistochemistry in our BLCA cohort (40 samples) (Fig. 1I).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "similar", "results", "were", "obtained", "through", "immunohistochemistry", "in", "our", "BLCA", "cohort", "(", "40", "samples", ")", "(", "Fig.", "1I", ")", "." ] } ]

PMC11740207

While MUSECs express similar multilineage differentiation markers to MIAMICs, they are notable due to their higher proliferative capacity (Alanazi et al., 2023).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "MUSECs", "express", "similar", "multilineage", "differentiation", "markers", "to", "MIAMICs", ",", "they", "are", "notable", "due", "to", "their", "higher", "proliferative", "capacity", "(", "Alanazi", "et", "al.", ",", "2023", ")", "." ] } ]

PMC11575040

The exclusion criteria are described as follows: belonging to a certain vulnerable population, and insufficient paraffin samples.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "exclusion", "criteria", "are", "described", "as", "follows", ":", "belonging", "to", "a", "certain", "vulnerable", "population", ",", "and", "insufficient", "paraffin", "samples", "." ] } ]

PMC7802142

The miRNA profiles in ReN-NV and 293-NV were detected by RNA sequencing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "miRNA", "profiles", "in", "ReN-NV", "and", "293-NV", "were", "detected", "by", "RNA", "sequencing", "." ] } ]

PMC11787651

These inhibitors can indirectly affect gene expression through crosstalk with DNA and histone methylation and cross-talk indirect modulation of other chromatin-associated protein activities (e.g., polycomb group and SWI–SNF [SWItch/Sucrose Non-Fermentable] complex [activity]) (62).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "inhibitors", "can", "indirectly", "affect", "gene", "expression", "through", "crosstalk", "with", "DNA", "and", "histone", "methylation", "and", "cross-talk", "indirect", "modulation", "of", "other", "chromatin-associated", "protein", "activities", "(", "e.g.", ",", "polycomb", "group", "and", "SWI", "–", "SNF", "[", "SWItch/Sucrose", "Non-Fermentable", "]", "complex", "[", "activity", "]", ")", "(", "62", ")", "." ] } ]

PMC8382973

Cytotoxicity was evaluated by calculating the cell viability = (OD450 of cell-HEC group − OD450 of blank control group)/(OD450 of HEC-free cell control group − OD450 of blank control group) × 100%.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cytotoxicity", "was", "evaluated", "by", "calculating", "the", "cell", "viability", "=", "(", "OD450", "of", "cell-HEC", "group", "−", "OD450", "of", "blank", "control", "group)/(OD450", "of", "HEC-free", "cell", "control", "group", "−", "OD450", "of", "blank", "control", "group", ")", "×", "100", "%", "." ] } ]

PMC11750712

Alternatively, the AUTO4 manufacturing process may have contributed to poor engraftment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Alternatively", ",", "the", "AUTO4", "manufacturing", "process", "may", "have", "contributed", "to", "poor", "engraftment", "." ] } ]

PMC11402217

This is the inaugural demonstration of apoptosis promotion through DKK1 inhibition in OS, bolstering the potential of DKK1 antagonists in OS treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "the", "inaugural", "demonstration", "of", "apoptosis", "promotion", "through", "DKK1", "inhibition", "in", "OS", ",", "bolstering", "the", "potential", "of", "DKK1", "antagonists", "in", "OS", "treatment", "." ] } ]

PMC11790971

Cell line predictions for monoclonal wells and artificial pools in different passages are shown in (g–i), (j–l), and (m–o) for passage 0, passage 1, and passage 2, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "line", "predictions", "for", "monoclonal", "wells", "and", "artificial", "pools", "in", "different", "passages", "are", "shown", "in", "(", "g", "–", "i", ")", ",", "(", "j", "–", "l", ")", ",", "and", "(", "m", "–", "o", ")", "for", "passage", "0", ",", "passage", "1", ",", "and", "passage", "2", ",", "respectively", "." ] } ]

PMC9065483

Fluorescence images were captured 24 hpi. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fluorescence", "images", "were", "captured", "24", "hpi", ".", "(" ] } ]

PMC11252553

The upper layer was composed and discarded after centrifugation (3000 rpm with monitoring room temperature for 30 min).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "upper", "layer", "was", "composed", "and", "discarded", "after", "centrifugation", "(", "3000", "rpm", "with", "monitoring", "room", "temperature", "for", "30", "min", ")", "." ] } ]

PMC8164677

It was found that the cellular accumulation of platinum for each sequence of administration was greater in the resistant cell line A2780 than the parent cell line A2780 (Figure 4).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "found", "that", "the", "cellular", "accumulation", "of", "platinum", "for", "each", "sequence", "of", "administration", "was", "greater", "in", "the", "resistant", "cell", "line", "A2780", "than", "the", "parent", "cell", "line", "A2780", "(", "Figure", "4", ")", "." ] } ]

PMC10055960

Single axial site functionalization was facilitated under stoichiometric control in order to achieve binding between the pyridyl nitrogen and dirhodium core.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Single", "axial", "site", "functionalization", "was", "facilitated", "under", "stoichiometric", "control", "in", "order", "to", "achieve", "binding", "between", "the", "pyridyl", "nitrogen", "and", "dirhodium", "core", "." ] } ]

PMC10033453

In this study, we show that the chimeric virus VMG exhibited multiple modes of efficacy, including viral oncolysis and resultant cytotoxic T cell tumor infiltration.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "we", "show", "that", "the", "chimeric", "virus", "VMG", "exhibited", "multiple", "modes", "of", "efficacy", ",", "including", "viral", "oncolysis", "and", "resultant", "cytotoxic", "T", "cell", "tumor", "infiltration", "." ] } ]

PMC10810426

siRNA-mediated knockdown of the indicated NUPs in NIH3T3 cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "siRNA-mediated", "knockdown", "of", "the", "indicated", "NUPs", "in", "NIH3T3", "cells", "." ] } ]

PMC11519567

B Representative images of EGFP, SS18-EGFP and SS18-SSX1-EGFP fusion protein overexpressed via lentiviral infection in BJ fibroblasts.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Representative", "images", "of", "EGFP", ",", "SS18-EGFP", "and", "SS18-SSX1-EGFP", "fusion", "protein", "overexpressed", "via", "lentiviral", "infection", "in", "BJ", "fibroblasts", "." ] } ]

PMC11552389

Following centrifugation, the total protein was collected.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Following", "centrifugation", ",", "the", "total", "protein", "was", "collected", "." ] } ]

PMC10956161

Moreover, the mutation frequency of the PRDX6 gene in lung adenocarcinoma ranked fourth among a range of cancers (Figure 1b).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "the", "mutation", "frequency", "of", "the", "PRDX6", "gene", "in", "lung", "adenocarcinoma", "ranked", "fourth", "among", "a", "range", "of", "cancers", "(", "Figure", "1b", ")", "." ] } ]

PMC11731614

Bonferroni adjusted p-value.

[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Bonferroni", "adjusted", "p-value", "." ] } ]

PMC11684269

Pyruvate dehydrogenase (PDH) is the key enzyme controlling the pyruvate flux that engages in the tricarboxylic acid (TCA) cycle.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pyruvate", "dehydrogenase", "(", "PDH", ")", "is", "the", "key", "enzyme", "controlling", "the", "pyruvate", "flux", "that", "engages", "in", "the", "tricarboxylic", "acid", "(", "TCA", ")", "cycle", "." ] } ]

PMC11361748

In (D), (F), and (H), PLA signals were quantified as the number of PLA dots per cell.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "(", "D", ")", ",", "(", "F", ")", ",", "and", "(", "H", ")", ",", "PLA", "signals", "were", "quantified", "as", "the", "number", "of", "PLA", "dots", "per", "cell", "." ] } ]

PMC9429973

Repeated dosing further enhanced efficacy in vivo.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Repeated", "dosing", "further", "enhanced", "efficacy", "in", "vivo", "." ] } ]

PMC9429973

Tocilizumab was administered during CRS for this patient, and the symptom was reversed afterwards.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tocilizumab", "was", "administered", "during", "CRS", "for", "this", "patient", ",", "and", "the", "symptom", "was", "reversed", "afterwards", "." ] } ]

PMC11612794

However, even at Aurora B less-kinetochores on aligned chromosomes, Mis12C localizes at kinetochores.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "even", "at", "Aurora", "B", "less-kinetochores", "on", "aligned", "chromosomes", ",", "Mis12C", "localizes", "at", "kinetochores", "." ] } ]

PMC11794847

Next, activated Jurkat cells were cultured under designated experimental conditions and then seeded at a density of approximately 2 × 10^5 cells per well in a specialized XFp cell culture miniplate.

[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "activated", "Jurkat", "cells", "were", "cultured", "under", "designated", "experimental", "conditions", "and", "then", "seeded", "at", "a", "density", "of", "approximately", "2", "×", "10", "^", "5", "cells", "per", "well", "in", "a", "specialized", "XFp", "cell", "culture", "miniplate", "." ] } ]

PMC11727145

Other manners in DED preparation and standardization may have other nutrient needs for cell adhesion and migration, but with the methodology provided herein, it was notably possible to simplify and observe differences when the bottom media was replaced with burn wound exudates.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "manners", "in", "DED", "preparation", "and", "standardization", "may", "have", "other", "nutrient", "needs", "for", "cell", "adhesion", "and", "migration", ",", "but", "with", "the", "methodology", "provided", "herein", ",", "it", "was", "notably", "possible", "to", "simplify", "and", "observe", "differences", "when", "the", "bottom", "media", "was", "replaced", "with", "burn", "wound", "exudates", "." ] } ]

PMC3995603

However, the efficacy of AC against atopic dermatitis (AD), an inflammatory disease, has not been examined.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "efficacy", "of", "AC", "against", "atopic", "dermatitis", "(", "AD", ")", ",", "an", "inflammatory", "disease", ",", "has", "not", "been", "examined", "." ] } ]

PMC11422150

The serum NO concentration, which typically increases during inflammatory responses, was significantly suppressed in the hAMSC treatment group (Figure 5), suggesting a systemic response.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "serum", "NO", "concentration", ",", "which", "typically", "increases", "during", "inflammatory", "responses", ",", "was", "significantly", "suppressed", "in", "the", "hAMSC", "treatment", "group", "(", "Figure", "5", ")", ",", "suggesting", "a", "systemic", "response", "." ] } ]

PMC11509278

Most of these studies have measured the effects of propolis harvested from different geographical regions on the growth, proliferation, and metastasis of cancer cells in vitro .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Most", "of", "these", "studies", "have", "measured", "the", "effects", "of", "propolis", "harvested", "from", "different", "geographical", "regions", "on", "the", "growth", ",", "proliferation", ",", "and", "metastasis", "of", "cancer", "cells", "in", "vitro", "." ] } ]

PMC11672881

Still, the combination treatment exhibits a broader and more significant enrichment of apoptosis-related terms, indicating a more effective induction of apoptosis through multiple pathways.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Still", ",", "the", "combination", "treatment", "exhibits", "a", "broader", "and", "more", "significant", "enrichment", "of", "apoptosis-related", "terms", ",", "indicating", "a", "more", "effective", "induction", "of", "apoptosis", "through", "multiple", "pathways", "." ] } ]

PMC10761218

Then, the plant material was rinsed once with sterile distilled water and weighted.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "the", "plant", "material", "was", "rinsed", "once", "with", "sterile", "distilled", "water", "and", "weighted", "." ] } ]

PMC11721587

Furthermore, the preexisting mature Fu purified from the in vitro maturation experiments failed to phosphorylate Sufu-bound Ci (Fig. 5F).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "the", "preexisting", "mature", "Fu", "purified", "from", "the", "in", "vitro", "maturation", "experiments", "failed", "to", "phosphorylate", "Sufu-bound", "Ci", "(", "Fig.", "5F", ")", "." ] } ]

PMC9429973

Aims: The aim of this study is the prospective evaluation of gonadal function in young women with malignant lymphoma who are receiving CT.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "The", "aim", "of", "this", "study", "is", "the", "prospective", "evaluation", "of", "gonadal", "function", "in", "young", "women", "with", "malignant", "lymphoma", "who", "are", "receiving", "CT", "." ] } ]

PMC11575040

Table S1 presents the TNM stages of these 112 patients in detail.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Table", "S1", "presents", "the", "TNM", "stages", "of", "these", "112", "patients", "in", "detail", "." ] } ]

PMC10965680

Specifically, PDGFRB gene insertion, deletions and indels were associated with improved litter size in goats (E et al., 2019).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specifically", ",", "PDGFRB", "gene", "insertion", ",", "deletions", "and", "indels", "were", "associated", "with", "improved", "litter", "size", "in", "goats", "(", "E", "et", "al.", ",", "2019", ")", "." ] } ]

PMC9000591

The achieved fractional extracts were preliminarily tested for biological activities.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "achieved", "fractional", "extracts", "were", "preliminarily", "tested", "for", "biological", "activities", "." ] } ]

PMC9318744

According to their prediction, the outer shell disorder of omicron is lower than that of other variants and might provide the omicron virion with a rigid outer shell that protects the virus from damage by salivary or mucosal antimicrobial enzymes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "their", "prediction", ",", "the", "outer", "shell", "disorder", "of", "omicron", "is", "lower", "than", "that", "of", "other", "variants", "and", "might", "provide", "the", "omicron", "virion", "with", "a", "rigid", "outer", "shell", "that", "protects", "the", "virus", "from", "damage", "by", "salivary", "or", "mucosal", "antimicrobial", "enzymes", "." ] } ]

PMC10758402

These results demonstrate that the combination of DMF and HSV.n212 therapy results in a greater therapeutic benefit compared to placebo or monotherapy in two different mouse models of cancer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "demonstrate", "that", "the", "combination", "of", "DMF", "and", "HSV.n212", "therapy", "results", "in", "a", "greater", "therapeutic", "benefit", "compared", "to", "placebo", "or", "monotherapy", "in", "two", "different", "mouse", "models", "of", "cancer", "." ] } ]

PMC11411004

According to the experimental results, the use of I-4 significantly elevated the expression of HC and LC mRNA by approximately 1.60-fold and 1.44-fold, respectively, compared with the control group without I-4 treatment (Fig. 4a, b).Fig.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "the", "experimental", "results", ",", "the", "use", "of", "I-4", "significantly", "elevated", "the", "expression", "of", "HC", "and", "LC", "mRNA", "by", "approximately", "1.60-fold", "and", "1.44-fold", ",", "respectively", ",", "compared", "with", "the", "control", "group", "without", "I-4", "treatment", "(", "Fig.", "4a", ",", "b).Fig", "." ] } ]

PMC9429973

The IL-1RN 1/3 and 1/4 genotypes were significantly more common in patients with MM compared to healthy controls.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IL-1RN", "1/3", "and", "1/4", "genotypes", "were", "significantly", "more", "common", "in", "patients", "with", "MM", "compared", "to", "healthy", "controls", "." ] } ]

PMC10198699

The history of the HeLa cell line raises several ethical and legal issues.

[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "history", "of", "the", "HeLa", "cell", "line", "raises", "several", "ethical", "and", "legal", "issues", "." ] } ]

PMC9587866

The predicted resolution of EYA3 model is 1.565 Å, which is considered good and valid for a constructed protein structure as proven by ResProX. Active Site Residues in EYA3 The active site residues were identified in order to direct the medicinal ligands toward the active pocket and inhibit the protein activity of EYA3.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "predicted", "resolution", "of", "EYA3", "model", "is", "1.565", "Å", ",", "which", "is", "considered", "good", "and", "valid", "for", "a", "constructed", "protein", "structure", "as", "proven", "by", "ResProX.", "Active", "Site", "Residues", "in", "EYA3", "The", "active", "site", "residues", "were", "identified", "in", "order", "to", "direct", "the", "medicinal", "ligands", "toward", "the", "active", "pocket", "and", "inhibit", "the", "protein", "activity", "of", "EYA3", "." ] } ]

PMC10560648

In conclusion, C. Andromeda venom can cause an apoptosis increase through upregulation of p15INK4b and P53 proteins and downregulation of Bcl-2, p21 , and DNMT1 in the Jurkat cell line.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "In", "conclusion", ",", "C.", "Andromeda", "venom", "can", "cause", "an", "apoptosis", "increase", "through", "upregulation", "of", "p15INK4b", "and", "P53", "proteins", "and", "downregulation", "of", "Bcl-2", ",", "p21", ",", "and", "DNMT1", "in", "the", "Jurkat", "cell", "line", "." ] } ]

PMC11659734

Moreover, 2D cultures may exhibit abnormal gene expression profiles.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "2D", "cultures", "may", "exhibit", "abnormal", "gene", "expression", "profiles", "." ] } ]

PMC6799808

Interestingly, treatment with GLPT (0–2 mg/ml) for 24 h increased the level of cleaved caspase 8 (Fig. 3b), indicating activation of caspase 8.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "treatment", "with", "GLPT", "(", "0–2", "mg/ml", ")", "for", "24", "h", "increased", "the", "level", "of", "cleaved", "caspase", "8", "(", "Fig.", "3b", ")", ",", "indicating", "activation", "of", "caspase", "8", "." ] } ]

PMC11787355

Finally, the column was re-equilibrated at 1% solvent B for 11 min.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "the", "column", "was", "re-equilibrated", "at", "1", "%", "solvent", "B", "for", "11", "min", "." ] } ]

PMC10366908

Using the CBIS method, we have developed mAbs against human antigens, including human epidermal growth factor receptor 2 (HER2) , human epidermal growth factor receptor 3 (HER3) , epithelial cell adhesion molecule (EpCAM) , trophoblast cell surface antigen 2 (TROP2) , programmed cell death ligand 1 (PD-L1) , podoplanin (PDPN) , the cluster of differentiation 19 (CD19) , CD20 , CD44 , CD133 , killer cell lectin-like receptor G1 (KLRG1) , C-C motif chemokine receptor 9 (CCR9) , and T cell immunoreceptor with Ig and ITIM domains (TIGIT) by the immunization of antigen-overexpressing cells in mice.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "the", "CBIS", "method", ",", "we", "have", "developed", "mAbs", "against", "human", "antigens", ",", "including", "human", "epidermal", "growth", "factor", "receptor", "2", "(", "HER2", ")", ",", "human", "epidermal", "growth", "factor", "receptor", "3", "(", "HER3", ")", ",", "epithelial", "cell", "adhesion", "molecule", "(", "EpCAM", ")", ",", "trophoblast", "cell", "surface", "antigen", "2", "(", "TROP2", ")", ",", "programmed", "cell", "death", "ligand", "1", "(", "PD-L1", ")", ",", "podoplanin", "(", "PDPN", ")", ",", "the", "cluster", "of", "differentiation", "19", "(", "CD19", ")", ",", "CD20", ",", "CD44", ",", "CD133", ",", "killer", "cell", "lectin-like", "receptor", "G1", "(", "KLRG1", ")", ",", "C-C", "motif", "chemokine", "receptor", "9", "(", "CCR9", ")", ",", "and", "T", "cell", "immunoreceptor", "with", "Ig", "and", "ITIM", "domains", "(", "TIGIT", ")", "by", "the", "immunization", "of", "antigen-overexpressing", "cells", "in", "mice", "." ] } ]

PMC7642379

Genes with high impact SNVs in progeny cell lines compared to the parental HEK293 can be found in Supplementary Table S2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genes", "with", "high", "impact", "SNVs", "in", "progeny", "cell", "lines", "compared", "to", "the", "parental", "HEK293", "can", "be", "found", "in", "Supplementary", "Table", "S2", "." ] } ]

PMC9268183

Based on this, and aiming at filling such caveat, the main objectives of this study were as follows: (i) to report the potential uses of plants in cancer treatment, including preventive and palliative applications, based on the information of traditional uses recorded in CLA; (ii) to carry out a literature review of pharmacological activity and uses of plants concerned; and (iii) to prove the importance of traditional knowledge as a starting point in the development of new plant-based drugs.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "this", ",", "and", "aiming", "at", "filling", "such", "caveat", ",", "the", "main", "objectives", "of", "this", "study", "were", "as", "follows", ":", "(", "i", ")", "to", "report", "the", "potential", "uses", "of", "plants", "in", "cancer", "treatment", ",", "including", "preventive", "and", "palliative", "applications", ",", "based", "on", "the", "information", "of", "traditional", "uses", "recorded", "in", "CLA", ";", "(", "ii", ")", "to", "carry", "out", "a", "literature", "review", "of", "pharmacological", "activity", "and", "uses", "of", "plants", "concerned", ";", "and", "(", "iii", ")", "to", "prove", "the", "importance", "of", "traditional", "knowledge", "as", "a", "starting", "point", "in", "the", "development", "of", "new", "plant-based", "drugs", "." ] } ]

PMC9429973

Four patients died due to shock with neurological involvement, respiratory failure, or multiple organic failure.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Four", "patients", "died", "due", "to", "shock", "with", "neurological", "involvement", ",", "respiratory", "failure", ",", "or", "multiple", "organic", "failure", "." ] } ]

PMC11803149

CAR-T cells with a central memory cell phenotype characterized by expression of CD62L and CD44 (CD62L CD44) exhibit high anti-tumor activity (31).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CAR-T", "cells", "with", "a", "central", "memory", "cell", "phenotype", "characterized", "by", "expression", "of", "CD62L", "and", "CD44", "(", "CD62L", "CD44", ")", "exhibit", "high", "anti-tumor", "activity", "(", "31", ")", "." ] } ]

PMC11365983

To validate these findings, we next assayed the effect of manipulating Foxc1 levels using a second cell line: immortalized embryonic primary chondrocytes that express high levels of endogenous Foxc1 (Supplemental Fig. 3).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "validate", "these", "findings", ",", "we", "next", "assayed", "the", "effect", "of", "manipulating", "Foxc1", "levels", "using", "a", "second", "cell", "line", ":", "immortalized", "embryonic", "primary", "chondrocytes", "that", "express", "high", "levels", "of", "endogenous", "Foxc1", "(", "Supplemental", "Fig.", "3", ")", "." ] } ]

PMC11657744

Cells were serum-starved (-SM) for 24 h to induce cilia formation and then treated with 10% serum-containing media (+ SM) for indicated times.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "serum-starved", "(", "-SM", ")", "for", "24", "h", "to", "induce", "cilia", "formation", "and", "then", "treated", "with", "10", "%", "serum-containing", "media", "(", "+", "SM", ")", "for", "indicated", "times", "." ] } ]

PMC11300085

RNAiso plus reagent (Takara, Tokyo, Japan) was applied to extract the total RNA following the manufacturer's instructions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNAiso", "plus", "reagent", "(", "Takara", ",", "Tokyo", ",", "Japan", ")", "was", "applied", "to", "extract", "the", "total", "RNA", "following", "the", "manufacturer", "'s", "instructions", "." ] } ]

PMC11381192

Distribution of risk score and survival status between CSI risk groups. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Distribution", "of", "risk", "score", "and", "survival", "status", "between", "CSI", "risk", "groups", ".", "(" ] } ]

PMC11754784

PAGE and DLS were used to characterize the assembly of DNP1 (Supplementary Fig. 8).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PAGE", "and", "DLS", "were", "used", "to", "characterize", "the", "assembly", "of", "DNP1", "(", "Supplementary", "Fig.", "8)", "." ] } ]

PMC6684588

In normal resting muscle, satellite cells express factors inhibitory to myogenesis, including myostatin and activin A, whereas fibroadipogenic progenitor cells express promyogenic factors such as follistatin.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "normal", "resting", "muscle", ",", "satellite", "cells", "express", "factors", "inhibitory", "to", "myogenesis", ",", "including", "myostatin", "and", "activin", "A", ",", "whereas", "fibroadipogenic", "progenitor", "cells", "express", "promyogenic", "factors", "such", "as", "follistatin", "." ] } ]

PMC11513011

Caspases are key mediators of apoptosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Caspases", "are", "key", "mediators", "of", "apoptosis", "." ] } ]

PMC10713411

Subsequently, we comprehensively explored the influence of TRIB3 on tumor growth and development by conducting cell viability assays, assessment of cell proliferation and migration capacity and colony formation experiments.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "we", "comprehensively", "explored", "the", "influence", "of", "TRIB3", "on", "tumor", "growth", "and", "development", "by", "conducting", "cell", "viability", "assays", ",", "assessment", "of", "cell", "proliferation", "and", "migration", "capacity", "and", "colony", "formation", "experiments", "." ] } ]

PMC11585565

Vision impairment, often starting in childhood or early adulthood, is a common symptom as retinal degeneration progresses, leading to cone-rod dystrophy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Vision", "impairment", ",", "often", "starting", "in", "childhood", "or", "early", "adulthood", ",", "is", "a", "common", "symptom", "as", "retinal", "degeneration", "progresses", ",", "leading", "to", "cone-rod", "dystrophy", "." ] } ]

PMC11803918

The blood samples were collected for flow cytometry and ELISpot assay.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "blood", "samples", "were", "collected", "for", "flow", "cytometry", "and", "ELISpot", "assay", "." ] } ]

PMC11676169

For the purification of BCAT1-associated proteins, 1 × 10 CUTLL1 cells stably expressing myc-DDK-tagged BCAT1 (BCAT1 myc/DDK) and control CUTLL1 cells were harvested by centrifugation and washed in cold PBS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "purification", "of", "BCAT1-associated", "proteins", ",", "1", "×", "10", "CUTLL1", "cells", "stably", "expressing", "myc-DDK-tagged", "BCAT1", "(", "BCAT1", "myc/DDK", ")", "and", "control", "CUTLL1", "cells", "were", "harvested", "by", "centrifugation", "and", "washed", "in", "cold", "PBS", "." ] } ]

PMC11747467

P-value < 0.05; **, P-value < 0.01; ***, P-value < 0.001; ****, P-value < 0.0001; ns, not significant.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P-value", "<", "0.05", ";", "*", "*", ",", "P-value", "<", "0.01", ";", "*", "*", "*", ",", "P-value", "<", "0.001", ";", "*", "*", "*", "*", ",", "P-value", "<", "0.0001", ";", "ns", ",", "not", "significant", "." ] } ]

PMC5034105

Twelve of these 14 cell lines (JEG-3, HEK, HeLa, LNCaP, SF268, RD, ARPE19, Hep-2, Calu-3, HFL, Caco-2 and Huh-7) showed obvious ZIKV-NS1 protein expression by IF in addition to a high viral load (Table 2).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twelve", "of", "these", "14", "cell", "lines", "(", "JEG-3", ",", "HEK", ",", "HeLa", ",", "LNCaP", ",", "SF268", ",", "RD", ",", "ARPE19", ",", "Hep-2", ",", "Calu-3", ",", "HFL", ",", "Caco-2", "and", "Huh-7", ")", "showed", "obvious", "ZIKV-NS1", "protein", "expression", "by", "IF", "in", "addition", "to", "a", "high", "viral", "load", "(", "Table", "2", ")", "." ] } ]

PMC9065483

Further investigation into this relationship would broaden our understanding of STAT2 regulation of the IFN-1 responses.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "investigation", "into", "this", "relationship", "would", "broaden", "our", "understanding", "of", "STAT2", "regulation", "of", "the", "IFN-1", "responses", "." ] } ]

PMC11402217

Transfection efficiency was verified by qPCR and fluorescence microscopy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transfection", "efficiency", "was", "verified", "by", "qPCR", "and", "fluorescence", "microscopy", "." ] } ]

PMC11190238

The EMT process is crucial during the gastrulation stage of early embryo development for neural crest cells to delaminate and embark on differentiation towards their derivatives.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "EMT", "process", "is", "crucial", "during", "the", "gastrulation", "stage", "of", "early", "embryo", "development", "for", "neural", "crest", "cells", "to", "delaminate", "and", "embark", "on", "differentiation", "towards", "their", "derivatives", "." ] } ]

PMC8806312

The top 5 terms for MF were as follows: receptor ligand activity, receptor regulator activity, carbohydrate binding, steroid hormone receptor activity and cytokine receptor activity (Figure 2(a)).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "top", "5", "terms", "for", "MF", "were", "as", "follows", ":", "receptor", "ligand", "activity", ",", "receptor", "regulator", "activity", ",", "carbohydrate", "binding", ",", "steroid", "hormone", "receptor", "activity", "and", "cytokine", "receptor", "activity", "(", "Figure", "2(a", ")", ")", "." ] } ]

PMC10114490

Toxicometabolomic analysis upon incubation with known active hepatic substances revealed that our diHLC-T outperform HepG2, probably due to the intense xenobiotic-related metabolic rewiring, including a general improvement of glutathione metabolic pathway.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Toxicometabolomic", "analysis", "upon", "incubation", "with", "known", "active", "hepatic", "substances", "revealed", "that", "our", "diHLC-T", "outperform", "HepG2", ",", "probably", "due", "to", "the", "intense", "xenobiotic-related", "metabolic", "rewiring", ",", "including", "a", "general", "improvement", "of", "glutathione", "metabolic", "pathway", "." ] } ]

PMC11291490

The gating strategy was shown in Supplementary Fig. 3.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gating", "strategy", "was", "shown", "in", "Supplementary", "Fig.", "3", "." ] } ]

PMC11653168

The present study also demonstrated the complex interaction between apoptosis and autophagy induced by Stattic in CCRF-CEM and Jurkat cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "present", "study", "also", "demonstrated", "the", "complex", "interaction", "between", "apoptosis", "and", "autophagy", "induced", "by", "Stattic", "in", "CCRF-CEM", "and", "Jurkat", "cells", "." ] } ]

PMC11699042

Here, we hypothesize that oligomutated pediatric sarcoma cell lines mainly driven by a fusion transcription factor, such as Ewing sarcoma (EwS), are genetically and phenotypically more stable than the previously investigated adult carcinoma cell lines.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Here", ",", "we", "hypothesize", "that", "oligomutated", "pediatric", "sarcoma", "cell", "lines", "mainly", "driven", "by", "a", "fusion", "transcription", "factor", ",", "such", "as", "Ewing", "sarcoma", "(", "EwS", ")", ",", "are", "genetically", "and", "phenotypically", "more", "stable", "than", "the", "previously", "investigated", "adult", "carcinoma", "cell", "lines", "." ] } ]

PMC11075223

Its structure was formed by a single glucose connecting two parts of cimifugin and FA .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Its", "structure", "was", "formed", "by", "a", "single", "glucose", "connecting", "two", "parts", "of", "cimifugin", "and", "FA", "." ] } ]

PMC11695623

Volcanic map of DCUN1D5 differential genes in TCGA-LUAD data set. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Volcanic", "map", "of", "DCUN1D5", "differential", "genes", "in", "TCGA-LUAD", "data", "set", ".", "(" ] } ]

PMC11799620

Finally, to explore its biological benefits and its protective effect against cadmium toxicity, these research investigators carried out (1) an in vitro protein glycation test, (2) MTT and inverted microscope imaging in HepG2 and HEK293 cell line, and (3) a lipid peroxidation test using rat erythrocytes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "to", "explore", "its", "biological", "benefits", "and", "its", "protective", "effect", "against", "cadmium", "toxicity", ",", "these", "research", "investigators", "carried", "out", "(", "1", ")", "an", "in", "vitro", "protein", "glycation", "test", ",", "(", "2", ")", "MTT", "and", "inverted", "microscope", "imaging", "in", "HepG2", "and", "HEK293", "cell", "line", ",", "and", "(", "3", ")", "a", "lipid", "peroxidation", "test", "using", "rat", "erythrocytes", "." ] } ]

PMC11756514

Binding of biotinylated mannan-binding lectin and (C) Binding of biotinylated Langerin ECD to the bacteria in either calcium or EDTA.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Binding", "of", "biotinylated", "mannan-binding", "lectin", "and", "(", "C", ")", "Binding", "of", "biotinylated", "Langerin", "ECD", "to", "the", "bacteria", "in", "either", "calcium", "or", "EDTA", "." ] } ]

PMC11361748

Solving this enigma requires additional studies but is poised to yield novel clues as to how to mitigate TAR in the setting of human chronic inflammatory skin diseases.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Solving", "this", "enigma", "requires", "additional", "studies", "but", "is", "poised", "to", "yield", "novel", "clues", "as", "to", "how", "to", "mitigate", "TAR", "in", "the", "setting", "of", "human", "chronic", "inflammatory", "skin", "diseases", "." ] } ]

PMC11585254

A complete list of new plasmids and construct assembly information described in this study are available in Supplemental Table 1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "complete", "list", "of", "new", "plasmids", "and", "construct", "assembly", "information", "described", "in", "this", "study", "are", "available", "in", "Supplemental", "Table", "1", "." ] } ]

PMC11678368

A higher IC50 value for healthy cells (e.g., BALB/3T3), may indicate better selectivity of the compound, leading to a lower risk of side effects while maintaining therapeutic efficacy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "higher", "IC50", "value", "for", "healthy", "cells", "(", "e.g.", ",", "BALB/3T3", ")", ",", "may", "indicate", "better", "selectivity", "of", "the", "compound", ",", "leading", "to", "a", "lower", "risk", "of", "side", "effects", "while", "maintaining", "therapeutic", "efficacy", "." ] } ]

PMC6163708

The most potent HH inhibitor GANT61 suppressed proliferation more or less in about half of tumor cell lines (the sensitive cells were eradicated presumably through apoptosis) and is a prime candidate as a compound for the combined therapy in many tumor types.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "most", "potent", "HH", "inhibitor", "GANT61", "suppressed", "proliferation", "more", "or", "less", "in", "about", "half", "of", "tumor", "cell", "lines", "(", "the", "sensitive", "cells", "were", "eradicated", "presumably", "through", "apoptosis", ")", "and", "is", "a", "prime", "candidate", "as", "a", "compound", "for", "the", "combined", "therapy", "in", "many", "tumor", "types", "." ] } ]

PMC11768281

These cells play a crucial role in detecting the parasite and initiating the immune response.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "cells", "play", "a", "crucial", "role", "in", "detecting", "the", "parasite", "and", "initiating", "the", "immune", "response", "." ] } ]

PMC9429973

Twenty-four percent of pts had a mean hemoglobin increase ≥1.5 g/dL from BL over 12 weeks without transfusions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twenty-four", "percent", "of", "pts", "had", "a", "mean", "hemoglobin", "increase", "≥1.5", "g/dL", "from", "BL", "over", "12", "weeks", "without", "transfusions", "." ] } ]

PMC10809689

Based on diagrams (a., c.) and protein bands (b., d.), the expression of these proteins in the Gal-9 treated group compared to the control and PMA group had a significant increase at 24 h after Gal-9 treatment (PG24) (p = 0.0001) followed by a decrease at 48th hour.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "diagrams", "(", "a.", ",", "c.", ")", "and", "protein", "bands", "(", "b.", ",", "d.", ")", ",", "the", "expression", "of", "these", "proteins", "in", "the", "Gal-9", "treated", "group", "compared", "to", "the", "control", "and", "PMA", "group", "had", "a", "significant", "increase", "at", "24", "h", "after", "Gal-9", "treatment", "(", "PG24", ")", "(", "p", "=", "0.0001", ")", "followed", "by", "a", "decrease", "at", "48th", "hour", "." ] } ]

PMC9046263

p < 0.05.Figure 4HML-6 is overexpressed in several glioma cell lines compared to astrocytes (A).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.05.Figure", "4HML-6", "is", "overexpressed", "in", "several", "glioma", "cell", "lines", "compared", "to", "astrocytes", "(", "A", ")", "." ] } ]

PMC11021472

About 85% of human circRNAs align to known genes, with the majority being derived from protein-coding exons and a smaller proportion originating from untranslated regions (UTRs) or introns.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "About", "85", "%", "of", "human", "circRNAs", "align", "to", "known", "genes", ",", "with", "the", "majority", "being", "derived", "from", "protein-coding", "exons", "and", "a", "smaller", "proportion", "originating", "from", "untranslated", "regions", "(", "UTRs", ")", "or", "introns", "." ] } ]

PMC9429973

The average time from RUX initiation was 22.1±14.5 (6-48) months.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "average", "time", "from", "RUX", "initiation", "was", "22.1±14.5", "(", "6", "-", "48", ")", "months", "." ] } ]

PMC11730311

Through attachment of lipid moieties, the acylated peptide can bind to serum albumin, which enables protection against renal excretion and enzymatic degradation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Through", "attachment", "of", "lipid", "moieties", ",", "the", "acylated", "peptide", "can", "bind", "to", "serum", "albumin", ",", "which", "enables", "protection", "against", "renal", "excretion", "and", "enzymatic", "degradation", "." ] } ]

PMC9429973

On multivariate analysis, only infection grade≥3 had statistical impact on mortality (p=0.027; HR 10.037).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "multivariate", "analysis", ",", "only", "infection", "grade≥3", "had", "statistical", "impact", "on", "mortality", "(", "p=0.027", ";", "HR", "10.037", ")", "." ] } ]

PMC7171147

The protein expression of CPT1A in normal ovaries and ovarian cancer was extracted from the Human Protein Atlas.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "expression", "of", "CPT1A", "in", "normal", "ovaries", "and", "ovarian", "cancer", "was", "extracted", "from", "the", "Human", "Protein", "Atlas", "." ] } ]

PMC8140214

Data are presented as mean±SD (n=4).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "presented", "as", "mean±SD", "(", "n=4", ")", "." ] } ]

PMC11790599

To further characterize the TSL-induced macropinosomes, we used F-actin polymerization inhibitor cytochalasin D (CytD) (Nakase et al., 2004), Rac1 inhibitor EHT1864, and the cholesterol-depleting agent Methyl-β-cyclodextrin (mβCD) (Ramirez et al., 2019) to modulate their development.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "further", "characterize", "the", "TSL-induced", "macropinosomes", ",", "we", "used", "F-actin", "polymerization", "inhibitor", "cytochalasin", "D", "(", "CytD", ")", "(", "Nakase", "et", "al.", ",", "2004", ")", ",", "Rac1", "inhibitor", "EHT1864", ",", "and", "the", "cholesterol-depleting", "agent", "Methyl-β-cyclodextrin", "(", "mβCD", ")", "(", "Ramirez", "et", "al.", ",", "2019", ")", "to", "modulate", "their", "development", "." ] } ]

PMC11391695

For immunohistochemical staining, paraffin-embedded sections were performed after the tumors were fixed in 4% paraformaldehyde.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "immunohistochemical", "staining", ",", "paraffin-embedded", "sections", "were", "performed", "after", "the", "tumors", "were", "fixed", "in", "4", "%", "paraformaldehyde", "." ] } ]

PMC11045125

The EBV negative Akata BL line and a BL5 EBV infected LCL serve as controls.

[ { "tags": [ "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "EBV", "negative", "Akata", "BL", "line", "and", "a", "BL5", "EBV", "infected", "LCL", "serve", "as", "controls", "." ] } ]

PMC9429973

Our PFS analysis showed that ACA-O was the best treatment in both MU/UN-only patients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "PFS", "analysis", "showed", "that", "ACA-O", "was", "the", "best", "treatment", "in", "both", "MU/UN-only", "patients", "." ] } ]

PMC6803987

Based on these data , the compound was identified as esculetin.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "these", "data", ",", "the", "compound", "was", "identified", "as", "esculetin", "." ] } ]

PMC10452486

D0 plays a central role in the stronger binding of KIR3DL2 to Face-2 of HLA-F, and Face-2 and Face-4 of HLA-I classes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D0", "plays", "a", "central", "role", "in", "the", "stronger", "binding", "of", "KIR3DL2", "to", "Face-2", "of", "HLA-F", ",", "and", "Face-2", "and", "Face-4", "of", "HLA-I", "classes", "." ] } ]

PMC11782780

Single-cell suspensions were plated into a 96-well ultra-low attachment plate (1,000 cells/well) in serum-free medium containing 2% B-27 (Invitrogen), 20 ‍ng/ml EGF (MCE), 20 ‍ng/ml bFGF (Invitrogen), and 10 ‍μg/ml heparin (Sigma, St. Louis, MO).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Single-cell", "suspensions", "were", "plated", "into", "a", "96-well", "ultra-low", "attachment", "plate", "(", "1,000", "cells/well", ")", "in", "serum-free", "medium", "containing", "2", "%", "B-27", "(", "Invitrogen", ")", ",", "20", "‍ng/ml", "EGF", "(", "MCE", ")", ",", "20", "‍ng/ml", "bFGF", "(", "Invitrogen", ")", ",", "and", "10", "‍μg/ml", "heparin", "(", "Sigma", ",", "St.", "Louis", ",", "MO", ")", "." ] } ]

PMC11188874

E.G7-Ova cells constitutively synthesize Ova and are a validated model to study MHC-I–restricted CTL activity.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E.G7-Ova", "cells", "constitutively", "synthesize", "Ova", "and", "are", "a", "validated", "model", "to", "study", "MHC-I", "–", "restricted", "CTL", "activity", "." ] } ]

PMC9429973

Therapy focused only on treating the underlying disease in 21 patients (19%) did not lead to an increase in Hb (p> 0.05), although patients subjectively noted an improvement in well-being.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therapy", "focused", "only", "on", "treating", "the", "underlying", "disease", "in", "21", "patients", "(", "19", "%", ")", "did", "not", "lead", "to", "an", "increase", "in", "Hb", "(", "p", ">", "0.05", ")", ",", "although", "patients", "subjectively", "noted", "an", "improvement", "in", "well-being", "." ] } ]

PMC11661024

Although there is a limitation among cancer individuals with considerable immune deficiencies to intake probiotics, few studies related to their anticancer activities are available.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "there", "is", "a", "limitation", "among", "cancer", "individuals", "with", "considerable", "immune", "deficiencies", "to", "intake", "probiotics", ",", "few", "studies", "related", "to", "their", "anticancer", "activities", "are", "available", "." ] } ]