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PMC9429973
82% (19/23) of which had unfavorable cytogenetics (defined by the presence of del (17p) or p53 mutation, t (4:14), t (14:16), t (14:20), amp (1q)).
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PMC11297139
Tested proteins include PrLD1, ARID, PrLD2, Pfam, PrLD(Y/S) mutant, and full-length ARID1A.
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PMC3995603
Consequently, the need to efficiently manage the AD response while reducing side effects has led to the development of alternative remedies.
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PMC11672881
CU, a polyphenol extracted from turmeric, demonstrates chemo-preventive and anti-tumor effects by regulating transcription factors and signaling pathways, such as the PI3K/mTOR, GSK-3beta, and Ras/Raf/MEK pathways .
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PMC6160470
Subsequently, cells were treated with freshly prepared compound solutions in blocking buffer and incubated for an additional 10 minutes at 37 °C.
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PMC9429973
Spleen size reduction is a function of baseline spleen size and was recently shown to be independent prognostic factor in composite PMF and SMF cohort of ruxolitinib treated patients.
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PMC9910796
Transfected Cos cells, plated at 80% confluency in 35 mm plates, were lysed in 1ml of 0.1% Triton X-100 in PBS containing a protease inhibitor cocktail (complete mini-EDTA free, Sigma).
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PMC11672602
Positive control of breast carcinoma was used, magnification X100. (
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PMC9429973
Methods: We analyzed multiple RNAseq gene expression data sets of cultured and uncultured human HSPCs from developmental and postnatal hematopoietic tissues to identify genes associated with self-renewing HSCs.
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PMC8409415
The sequences of the primers used were as follows: human CD70 (180 bp), forward primer 5‐GCCCTATGGGTGCGTCCTGC‐3 and reverse primer 5‐AGCCTGGGGTCCTGCTGAGG‐3; β‐actin (174 bp), 5‐AGCCTCGCCTTTGCCGA‐3 (forward), and 5‐CTGGTGCCTGGGGCG‐3 (reverse).
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PMC11349530
MCP-1 produced by cancer cells can attract macrophages and induce Wnt-1 upregulation, downregulating E-cadherin junctions in breast cancer cells and stimulating tumor cell dissemination (70).
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PMC9429973
The early PFS and OS appears comparable to historical real-world outcome of intensified regimens such as R-DA-EPOCH.
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PMC4695073
It involves several factors assembling with an ordered and stepwise manner.
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PMC11718109
Excitation wavelengths between 405 and 640 nm, CFI SR Plan ApoIR 60XC WI objective lens and SoRa lens-switched light path at 1x, 2.8x or 4x were used.
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PMC4360730
Missing ontology terms or terms that contain inconsistencies are reported to the ontology developers via public issue tracking systems.
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PMC9429973
Image: Summary/Conclusion: ThisCART19A cells demonstrated potent CD19-dependent cytotoxicity and no xenogentic GvHD in murine models.
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PMC10213199
In the HL 60 cell line, JYL activated proteasome-related functions.
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PMC9429973
No differences were found of older age and other known risk factors.
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PMC10329237
It seems that the combination of drugs was more effective than the single ones in regulating the oxidative parameters in A549 cells.
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PMC11462673
B Motif analysis of LDB1 binding sites in 6 T-CEM cells using Homer (22).
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PMC11194678
Total RNA was reverse transcribed by using PrimerScript RTreagent Kit with gDRNA Eraser (Takara) according to the manufacturer’s instructions.
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PMC11354225
In HaCat cells, EGCG (<12.5 μM, >24 h) shows antioxidant and cytoprotective capabilities .
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PMC7305184
Electroporation or pulsed electric field (PEF) treatment can cause increase in membrane permeability and allows molecules, for which the membrane is mostly impermeable, to cross.
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PMC7192625
A considerable number of papers have suggested interpreting chromatin structure as a network, either starting from Hi-Ccontact maps interpreted as distance matrices, see for example (17–23), or also increasingly using alternative chromosome capture techniques that detect longer-range specific contacts directly (24).
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PMC9429973
Methods: Chemical biology, animal models, functional genetics Results: BTM-3566 is a small molecule based on a pyrazolothiazol-backbone.
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PMC10577955
Where the activated caspase-8 can directly stimulate caspase-3 activity .
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PMC9429973
Many circRNAs have been shown to bind microRNAs (miRNAs), thus making miRNAs unavailable to regulate protein-coding gene expression.
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PMC11502962
The interaction numbers and interaction weights of cell-to-cell were analyzed in G01 and G02 as shown in Figure 3 .
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PMC11095939
We first performed ChIP-qPCR to confirm the significantly decreased binding intensity of Mecp2 at proximal promoter regions of both Rara and Nr1h3 upon exit quiescence (Figure 7A).
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PMC11180402
Cancer metastasis includes multiple steps, such as local tumor cell invasion, entry into the vasculature, cancer cell exit from circulation, and colonization at distal sites .
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PMC11697065
To quantify expression of the human transgenes, the FASTA sequences of the antibody chains were added to the Chinese hamster reference genome.
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PMC11670407
Survival analysis was performed using the R software package "survival" to investigate the correlation between the expression levels of key genes and prognosis, and to observe the differences in the expression of key genes in normal tissues and paracancerous tissues, and the above bioinformatic analyses were visualized using the R software.
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PMC9429973
Exploiting new forms of cell death therefore may allow novel therapeutic options to limit survival or occurrence of resistant clones.
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PMC11026382
20 µL of the recovery culture was serially diluted and plated on LB-agar with 50 µg/mL thymidine and 30 µg/mL chloramphenicol, to permit quantification of transformants and estimate library coverage following ligation into the alternate TYMS backgrounds.
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PMC11767817
From a chemical perspective, BF2–curcumin complexes can serve as fluorescent dyes since this modification improves fluorescence quantum yields and increases Stokes shifts .
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PMC7185206
P < .05 was considered statistically significant.
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PMC11638255
Fig. 1), with these results underscoring an exclusive relationship between copper chelation and tumoral neutrophil recruitment.
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PMC11143482
The phrase ‘humanised mice’ has often been used to refer to genetically engineered immunodeficient mice that enable the growth of human immune cells .
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PMC9954564
Although not as extensively investigated as the 14 bp insertion/deletion (INDEL) and +3142, +3187 was already evaluated for preeclampsia , septic shock , malaria , leprosy , celiac disease , rheumatoid arthritis , schizophrenia , HTLV1 infection , bipolar disorder , epithelial ovarian cancer , and vitiligo ; it is observed in the latter similar association pattern, which is expected once there is a sample overlap between both studies.
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PMC11539788
qRT‒PCR analysis of RNF19A mRNA levels in normal and BCa tissues. (
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PMC11730000
CHO-K1 cells were obtained from the Institute of Pharmacology and Toxicology, Würzburg, Germany.
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PMC11629461
The alternating (340/380 nm) excitation light intensity at the cell level was 0.370–1.092 μWatt/cm.
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PMC11727062
This includes a range of natural products and their derivatives, such as agaric (if ‘acacia ear’ refers to a type of mushroom), heavy floor (which may need clarification or correction), paclitaxel alkaloids, and essential oils (Xiao et al. 2012).
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PMC6024716
The study was conducted in two directions; first, the focus was on finding microRNA that have a direct effect on protein expression; and the second was focused on finding specific genes whose inactivation by siRNA improved expression.
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PMC10729469
Antigen-specific Tregs migrate and accumulate at the site of cognate antigen expression where they exert both bystander and antigen-specific immune responses, and reduce complications associated with broad immunosuppression .
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PMC11737091
Box plot depicting the IHC staining scores for DBF4 in 69 paired ccRCC samples. *,
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PMC11401350
In this context, we previously used an anti-PD-1 antibody in combination with a non-canonical NF-kB inhibitor to treat mice bearing AITL tumors.
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PMC11337594
The activated CASP3 initiated apoptosis, while simultaneously continuing to cleave the GSDME, thereby triggering pyroptosis.
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PMC9532503
Fig. 1Diagrams showing the expression vectors with the cloned light (A) and heavy chain (B) sequences.
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PMC10631132
Scale bars: A, C, E, G = 250 µm, B, D, F, H = 50 µm TRAP staining of cells following osteoclast differentiation in conjunction with methyl green nuclear counterstaining.
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PMC11731614
MIPS was set as on, included charge states = 2–7 (reject unassigned).
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PMC10890307
Interestingly, qP Lactate of MCR-5 cells was higher when they were grown in Glc/pH6.2/N as compared to when they were cultured in Glc/pH6.2/H, indicating that MRC-5 cells can produce lactate under normoxia as well as under hypoxia (Table 3).
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PMC9412887
A variety of hybrid nanoparticles have been widely studied for overcoming cancer drug resistance, including breast cancer, ovarian cancer, lung cancer, and melanoma.
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PMC11767725
This metabolic shift reduces ATP availability and affects keratinocyte turnover, creating niches that favor anaerobic or facultative anaerobic microbes such as C. acnes and Pseudomonas aeruginosa.
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PMC9429973
Aims: To conduct an SLR on the real-world HRQoL burden across the entire spectrum of thalassemia and report evidence gaps.
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PMC4839679
To further define the G1/G0 arrest observed with PBRM1 re-expression we wished to determine whether increased apoptosis contributes to the G1/G0 cell cycle block.
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PMC11549062
Additionally, carotid plaque apoptosis was assessed through TUNEL staining.
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PMC9429973
Methods: In this prospective, single-arm, phase 2 trial, we recruited patients aged 18–70 years with newly diagnosed NKTCL who were EBV-DNA positive in plasma in Henan People’s Hospital.
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PMC11637284
The TAC60 segment Q178-M194 marks the minimal p166 binding site in the IMS domain of TAC60, which is in agreement with the domain identified in the AlphaFold2 structure model.
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PMC9429973
Most activating receptors, cell adhesion molecule receptors and chemokine receptors exhibited enhanced expression on expanded NK cells (figure 1a).
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PMC9429973
Due to imatinib resistance during follow-up, 40.5% of patients require the use of newer generation of TKI.
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PMC11754784
Source data are provided as a Source Data file.
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PMC11615218
Advances in genome editing have also helped overcome metabolic restriction in tumor microenvironments.
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PMC11635519
The cells were selected with the hygromycin antibiotic.
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PMC11612315
Noxious heat-evoked withdrawal behaviors in rats are suppressed during self-initiated chocolate eating and the ingestion of sucrose.
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PMC11257988
Thus, the development of clinical SOS1 compounds in combination with MEK inhibitors and potentially other RTK/MAPK pathway inhibitors holds promise for significant clinical benefits .
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PMC11723947
a Pattern of expression of genes overexpressed in Treg-exposed HP1γ KO Tconv compared with WT Tconv. (
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PMC11766174
As a negative control, Jurkat cells were used to set the baseline (Figure 2C,D; ‘0’ cells condition).
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PMC10877303
The stability and rigidity of these protein-ligand complexes throughout the simulation period were confirmed through a molecular dynamics simulation study.
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PMC10728200
H GIST-T1 and 882 cells were treated with IM (50 nM for T1 and 200 nM for 882) for 12 h with or without STUB1 knockdown, and the relative lipid ROS levels were assayed via flow cytometry.
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PMC7081114
In China, its incidence and mortality ranked fourth and third, respectively.
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PMC10938336
Apoptosis, which is a process of planned cell death, can be brought on by a variety of factors, including cellular stress, DNA damage, and immune surveillance.
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PMC6835428
Thus, their effectiveness in siRNA delivery can be significantly diminished.
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PMC5963610
White bars=100μm.
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PMC11218145
However, an evaluation of mitochondrial uncouplers as anti-cancer agents in a model of MPM, both in vitro and in vivo, is still lacking.
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PMC11604768
Our engineered reporters are activated by transcription factors and report on signal input at a layer in signal transduction independent of genomic context.
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PMC11593713
They differ in the course of infection, the susceptibility of populations, the seasonality of circulation, and the mode and ease of transmission.
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PMC11026382
Through this mini-screen we selected two mutations that stably expressed, purified robustly, and yielded intermediate activities: TYMS R127A and Q33S (Fig. 2a).
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PMC11470999
Melanoma has the highest incidence of brain metastasis among all cancers.
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PMC11697065
The stained cells were analysed by a MACSQuant flow cytometer with APC and FITC double-positive population measured according to manufacturer’s specifications.
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PMC11411004
Taken together, the results of the this study suggest that the small-molecule dual-targeting inhibitor I-4 can be used as an effective chemical additive to improve the yield of monoclonal antibodies in recombinant CHO cell cultures.
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PMC9479186
We designed three target shRNA for NDUFC1, respectively, 5’-AAAGAAGAAATGGGCTGGAAT-3’, 5’-GTGGATCTATCTCATCAAACA-3’, 5’-ATCAAAGTTCTACGTGCGAGA-3’.
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PMC4360730
Here, we present the ontologies we use to annotate experimental metadata to provide improved searching capabilities across the data and to build a technical framework for ensuring the accuracy of the metadata.
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PMC9429973
Most of parameters and scoring systems analyzed were useful to predict outcome from diagnosis or from treatment initiation to last follow up.
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PMC11222184
Total protein isolation was performed with RIPA buffer and total protein concentration was determined using the BCA protein assay kit.
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PMC6133382
Similarly, we noted a significant improvement in the binding of the PGT126 and PGT128 bN-mAbs that require oligomannose glycans at the N301 and N332 glycosylation sites in the stem of the V3 domain .
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PMC11283030
E-cad: E-cadherin, N-cad: N-cadherin, Vim: Vimentin.
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PMC8481254
This evidence broadens our understanding of the antitumor mechanism of CA and suggests that CA is a potential antitumor drug for the prevention and treatment of diabetes-associated liver cancer.
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PMC5600151
Another study from this group also showed that alkylated PAMAM G1 dendrimer could be used in siRNA delivery.
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PMC9429973
Therefore, targeting cells with lower CHD4 expression with compounds targeting DNA/RNA synthesis may have an impact on patient outcome.
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PMC11365983
Cells and isolated tissue were lysed in 1.5% SDS lysis buffer (50 mM Tris pH 7.5, 150 mM NaCl, 1 mM EDTA, 1.5% SDS) supplemented with protease/phosphatase inhibitor cocktail (1 mM PMSF, 10 µg/ml aprotinin, 10 µg/ml leupeptin or Halt Protease Inhibitor Cocktail (Thermo); 0.5 mM Na3VO4, 5 mM NaF, 10 mM β-glycerophosphate) and passed through QIAshredder columns (Qiagen).
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PMC9429973
Results: We screened 286 pts between 2016 and 2020, whereof 20 were excluded mainly due to lack of genetic aberration or no HCT performed.
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PMC9429973
National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation; XiaoJun Huang, Correspondence.
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PMC11765879
The peaks were detected at 280 nm by Waters© Empower chromatographic software version 3.8.0.
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PMC11323699
Furthermore, macrophages treated with a PARPi displayed a pro-inflammatory phenotype marked by increased expression of IL-1β .
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PMC11509309
Extracts displaying an anti-prion activity against both [PSI+] and [URE3] yeast prions were then selected for further analysis.
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PMC9429973
Further longitudinal studies with inferential statistics are needed in this context.
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PMC11585994
T-cell acute lymphoblastic leukemia (T-ALL) is a malignant hematological disease with limited targeted therapy options.
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PMC11679033
In general, obtained results indicate that potentially useful effects of CBD established on the lymphocyte model are modulated by the presence of CIT.
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PMC11461025
More recently, there have been reports that have demonstrated that ERK activation facilitates apoptosis of cells treated with a number of different drugs (Cagnol and Chambard 2010; Sugiura et al. 2021) .
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