OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11803149	Eight days later, young and aged OT-I TCR-T cells were adoptively transferred into young and aged tumor-bearing mice, respectively (A) or into young tumor-bearing mice (B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eight", "days", "later", ",", "young", "and", "aged", "OT-I", "TCR-T", "cells", "were", "adoptively", "transferred", "into", "young", "and", "aged", "tumor-bearing", "mice", ",", "respectively", "(", "A", ")", "or", "into", "young", "tumor-bearing", "mice", "(", "B", ")", "." ] } ]
PMC10197932	To evaluate this hypothesis, we also analyzed GSH content after 30 min post-US treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "evaluate", "this", "hypothesis", ",", "we", "also", "analyzed", "GSH", "content", "after", "30", "min", "post-US", "treatment", "." ] } ]
PMC11665584	Macrophage 2 was enriched for Spp1, a marker of another antiinflammatory macrophage subpopulation (34).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Macrophage", "2", "was", "enriched", "for", "Spp1", ",", "a", "marker", "of", "another", "antiinflammatory", "macrophage", "subpopulation", "(", "34", ")", "." ] } ]
PMC9275501	Angelica polysaccharide (ASP) could protect bone marrow stromal cells from 5-FU chemotherapy damage (Xiao et al., 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Angelica", "polysaccharide", "(", "ASP", ")", "could", "protect", "bone", "marrow", "stromal", "cells", "from", "5-FU", "chemotherapy", "damage", "(", "Xiao", "et", "al.", ",", "2017", ")", "." ] } ]
PMC8759873	However, how to transfer the VHL gene safely, efficiently, specifically, and stably to tumor target cells for gene therapy is an urgent problem to be solved.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "how", "to", "transfer", "the", "VHL", "gene", "safely", ",", "efficiently", ",", "specifically", ",", "and", "stably", "to", "tumor", "target", "cells", "for", "gene", "therapy", "is", "an", "urgent", "problem", "to", "be", "solved", "." ] } ]
PMC11727000	The target-decoy-based false discovery rate (FDR) filter for spectrum and protein identification was set to 1%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "target-decoy-based", "false", "discovery", "rate", "(", "FDR", ")", "filter", "for", "spectrum", "and", "protein", "identification", "was", "set", "to", "1", "%", "." ] } ]
PMC10606998	For low-grade gliomas, long-term survival exceeds 90%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "low-grade", "gliomas", ",", "long-term", "survival", "exceeds", "90", "%", "." ] } ]
PMC6835428	Another target able to induce chemo-resistance is the Focal adhesion kinase (FAK).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "target", "able", "to", "induce", "chemo-resistance", "is", "the", "Focal", "adhesion", "kinase", "(", "FAK", ")", "." ] } ]
PMC10654497	Importantly, our approach may be helpful in analyzing variations in the immune microenvironment among various patients with adenocarcinoma. "	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", "our", "approach", "may", "be", "helpful", "in", "analyzing", "variations", "in", "the", "immune", "microenvironment", "among", "various", "patients", "with", "adenocarcinoma", ".", "\"" ] } ]
PMC8009078	Due to its fast in execution, trustworthy and ease to use, molecular docking has become favorable to the wider community of researchers from academia and industry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", "to", "its", "fast", "in", "execution", ",", "trustworthy", "and", "ease", "to", "use", ",", "molecular", "docking", "has", "become", "favorable", "to", "the", "wider", "community", "of", "researchers", "from", "academia", "and", "industry", "." ] } ]
PMC11762280	ZBP1, also known as DNA-dependent activator of IRFs (DAI), was originally found to be strongly induced by IFN-γ or lipopolysaccharide (LPS) and to play an important role in DNA-mediated activation of innate immunity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ZBP1", ",", "also", "known", "as", "DNA-dependent", "activator", "of", "IRFs", "(", "DAI", ")", ",", "was", "originally", "found", "to", "be", "strongly", "induced", "by", "IFN-γ", "or", "lipopolysaccharide", "(", "LPS", ")", "and", "to", "play", "an", "important", "role", "in", "DNA-mediated", "activation", "of", "innate", "immunity", "." ] } ]
PMC11684297	In our recent study, we have shown that ZnO nanosheets also exhibited anticancer activity against A549 and A375 cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "In", "our", "recent", "study", ",", "we", "have", "shown", "that", "ZnO", "nanosheets", "also", "exhibited", "anticancer", "activity", "against", "A549", "and", "A375", "cells", "." ] } ]
PMC11224020	Data were analyzed by multiple unpaired Student’s t-tests; *P = 0.0001; **P < 0.0001.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "analyzed", "by", "multiple", "unpaired", "Student", "’s", "t-tests", ";", "", "", "", "P", "=", "0.0001", ";", "", "", "", "*", "P", "<", "0.0001", "." ] } ]
PMC11742231	Recent advancements in graph neural networks (GNNs) have shown great promise in drug response prediction by effectively modeling the intricate relationships between drugs and cancer cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "advancements", "in", "graph", "neural", "networks", "(", "GNNs", ")", "have", "shown", "great", "promise", "in", "drug", "response", "prediction", "by", "effectively", "modeling", "the", "intricate", "relationships", "between", "drugs", "and", "cancer", "cell", "lines", "." ] } ]
PMC11530949	The biosynthesized Ag-doped CuO NPs, in particular, demonstrated superior cytotoxic efficiency, likely due to the additional benefits of the plant-derived capping and stabilizing agents that enhance the NPs' stability and biocompatibility (59, 60).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "biosynthesized", "Ag-doped", "CuO", "NPs", ",", "in", "particular", ",", "demonstrated", "superior", "cytotoxic", "efficiency", ",", "likely", "due", "to", "the", "additional", "benefits", "of", "the", "plant-derived", "capping", "and", "stabilizing", "agents", "that", "enhance", "the", "NPs", "'", "stability", "and", "biocompatibility", "(", "59", ",", "60", ")", "." ] } ]
PMC9516401	T2DM arises from unacceptable insulin levels and/or improper responses to this hormone that controls blood sugar levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "T2DM", "arises", "from", "unacceptable", "insulin", "levels", "and/or", "improper", "responses", "to", "this", "hormone", "that", "controls", "blood", "sugar", "levels", "." ] } ]
PMC11676169	The BCAT1-binding region of KU80 was similarly determined using HA-tagged KU80 full-length protein and deletion mutants (aa 1–240; aa 241–550; aa 551–732).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "BCAT1-binding", "region", "of", "KU80", "was", "similarly", "determined", "using", "HA-tagged", "KU80", "full-length", "protein", "and", "deletion", "mutants", "(", "aa", "1–240", ";", "aa", "241–550", ";", "aa", "551–732", ")", "." ] } ]
PMC10988555	Data acquisition, integration, and handling were made resorting to the software package EAGER-200 (Carlo Erba Instruments).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "acquisition", ",", "integration", ",", "and", "handling", "were", "made", "resorting", "to", "the", "software", "package", "EAGER-200", "(", "Carlo", "Erba", "Instruments", ")", "." ] } ]
PMC10956161	Several studies have found similar results in lung cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Several", "studies", "have", "found", "similar", "results", "in", "lung", "cancer", "." ] } ]
PMC9429973	Aims: The aim of this work was to characterize the immune cell composition of blood and BM samples from CCUS/MDS patients and investigate the presence of circulating anti-Treg cells in blood samples and their reactivity towards immunogenic peptides.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "The", "aim", "of", "this", "work", "was", "to", "characterize", "the", "immune", "cell", "composition", "of", "blood", "and", "BM", "samples", "from", "CCUS/MDS", "patients", "and", "investigate", "the", "presence", "of", "circulating", "anti-Treg", "cells", "in", "blood", "samples", "and", "their", "reactivity", "towards", "immunogenic", "peptides", "." ] } ]
PMC11001582	After approximately 24 h, 600 ng ml puromycin was applied for a further 48 h to allow transient selection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "approximately", "24", "h", ",", "600", "ng", "ml", "puromycin", "was", "applied", "for", "a", "further", "48", "h", "to", "allow", "transient", "selection", "." ] } ]
PMC11715644	While wild-type MCF10A cells migrated faster in narrow channels, this confinement sensitivity was reduced after +ErbB2 mutation or with constitutively active RhoA. This physical interpretation of collective cell migration as density and shape transitions in granular matter could advance our understanding of complex living systems.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "wild-type", "MCF10A", "cells", "migrated", "faster", "in", "narrow", "channels", ",", "this", "confinement", "sensitivity", "was", "reduced", "after", "+", "ErbB2", "mutation", "or", "with", "constitutively", "active", "RhoA.", "This", "physical", "interpretation", "of", "collective", "cell", "migration", "as", "density", "and", "shape", "transitions", "in", "granular", "matter", "could", "advance", "our", "understanding", "of", "complex", "living", "systems", "." ] } ]
PMC11768281	This understanding suggests enhancing co-stimulatory molecules and blocking co-inhibitory pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "understanding", "suggests", "enhancing", "co-stimulatory", "molecules", "and", "blocking", "co-inhibitory", "pathways", "." ] } ]
PMC11429241	TWIST1 encodes a transcription factor that regulates the process, promoting the downregulation of CDH1 and rgw upregulation of CDH2, where epithelial cells lose their cell–cell adhesion properties (mediated by E-cadherin) and gain migratory and invasive properties (mediated by N-cadherin) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TWIST1", "encodes", "a", "transcription", "factor", "that", "regulates", "the", "process", ",", "promoting", "the", "downregulation", "of", "CDH1", "and", "rgw", "upregulation", "of", "CDH2", ",", "where", "epithelial", "cells", "lose", "their", "cell", "–", "cell", "adhesion", "properties", "(", "mediated", "by", "E-cadherin", ")", "and", "gain", "migratory", "and", "invasive", "properties", "(", "mediated", "by", "N-cadherin", ")", "." ] } ]
PMC11731614	Another differentially expressed pathway was ‘Neurotransmitter Secretion’ (Fig. 3G right; adjusted p-value ≤ 0.05), consistent with the physical localization of DRG nerve afferents, which tunnel through the keratinocyte cytoplasm to form synapse-like contacts (Talagas, 2020, Erbacher, 2024).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "differentially", "expressed", "pathway", "was", "‘", "Neurotransmitter", "Secretion", "’", "(", "Fig.", "3", "G", "right", ";", "adjusted", "p-value", "≤", "0.05", ")", ",", "consistent", "with", "the", "physical", "localization", "of", "DRG", "nerve", "afferents", ",", "which", "tunnel", "through", "the", "keratinocyte", "cytoplasm", "to", "form", "synapse-like", "contacts", "(", "Talagas", ",", "2020", ",", "Erbacher", ",", "2024).Fig", "." ] } ]
PMC9341513	On the other hand, there is some interaction between the insert and LTO1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "other", "hand", ",", "there", "is", "some", "interaction", "between", "the", "insert", "and", "LTO1", "." ] } ]
PMC11633763	To confirm this hypothesis, we examined the effects of USP22 knockdown and overexpression on the expression of HK2 and β‐catenin in 143B cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "To", "confirm", "this", "hypothesis", ",", "we", "examined", "the", "effects", "of", "USP22", "knockdown", "and", "overexpression", "on", "the", "expression", "of", "HK2", "and", "β‐catenin", "in", "143B", "cells", "." ] } ]
PMC11640247	Visualization of the corpus callosum at P0 showed significantly delayed axonal extension in RAC3-R66W-expressing neurons compared to controls (Figure 5A,B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Visualization", "of", "the", "corpus", "callosum", "at", "P0", "showed", "significantly", "delayed", "axonal", "extension", "in", "RAC3-R66W-expressing", "neurons", "compared", "to", "controls", "(", "Figure", "5A", ",", "B", ")", "." ] } ]
PMC3734024	To understand how FasL B cells relate to previously-identified B cell subsets, we compared surface expression of several B cell subset markers in FasL and FasL B cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "understand", "how", "FasL", "B", "cells", "relate", "to", "previously-identified", "B", "cell", "subsets", ",", "we", "compared", "surface", "expression", "of", "several", "B", "cell", "subset", "markers", "in", "FasL", "and", "FasL", "B", "cells", "." ] } ]
PMC11025866	Within the group of cells exposed to any HDACi, gene expression in cells treated with NaB, VPA, or NaB+VPA were the most similar and the gene expression pattern within each group of replicates were more similar to each other than between two replicates with identical conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Within", "the", "group", "of", "cells", "exposed", "to", "any", "HDACi", ",", "gene", "expression", "in", "cells", "treated", "with", "NaB", ",", "VPA", ",", "or", "NaB+VPA", "were", "the", "most", "similar", "and", "the", "gene", "expression", "pattern", "within", "each", "group", "of", "replicates", "were", "more", "similar", "to", "each", "other", "than", "between", "two", "replicates", "with", "identical", "conditions", "." ] } ]
PMC9429973	In this study, we retrospectively analyzed 417 newly diagnosed primary MDS cases in our hospital and to compare the clinical characteristics, prognosis and gene mutations of the two group patients with or without myelofibrosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "we", "retrospectively", "analyzed", "417", "newly", "diagnosed", "primary", "MDS", "cases", "in", "our", "hospital", "and", "to", "compare", "the", "clinical", "characteristics", ",", "prognosis", "and", "gene", "mutations", "of", "the", "two", "group", "patients", "with", "or", "without", "myelofibrosis", "." ] } ]
PMC11400680	Sphericity of segmented cells and nuclei. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sphericity", "of", "segmented", "cells", "and", "nuclei", ".", "(" ] } ]
PMC11564322	The data are expressed as means ± SD of three independent experiments, each of which consisted of six replicates per treatment group. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "are", "expressed", "as", "means", "±", "SD", "of", "three", "independent", "experiments", ",", "each", "of", "which", "consisted", "of", "six", "replicates", "per", "treatment", "group", ".", "*" ] } ]
PMC9429973	A patient with a previous AIHA, relapsed as immune thrombocytopenic purpura during pregnancy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "patient", "with", "a", "previous", "AIHA", ",", "relapsed", "as", "immune", "thrombocytopenic", "purpura", "during", "pregnancy", "." ] } ]
PMC11087766	Infections with all of these mutant phages appeared to progress normally and still concentrate sfGFP-tagged PhiKZ nuclear proteins (SI Appendix, Fig. S3), suggesting that import of endogenous phage proteins is not strongly affected by these point mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Infections", "with", "all", "of", "these", "mutant", "phages", "appeared", "to", "progress", "normally", "and", "still", "concentrate", "sfGFP-tagged", "PhiKZ", "nuclear", "proteins", "(", "SI", "Appendix", ",", "Fig.", "S3", ")", ",", "suggesting", "that", "import", "of", "endogenous", "phage", "proteins", "is", "not", "strongly", "affected", "by", "these", "point", "mutations", "." ] } ]
PMC11792888	Therefore, natural products show varying synergistic mechanisms to enhance the anticancer effects of etoposide.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "natural", "products", "show", "varying", "synergistic", "mechanisms", "to", "enhance", "the", "anticancer", "effects", "of", "etoposide", "." ] } ]
PMC9318744	An mNeonGreen-labeled infectious clone-derived strain (icSARS-CoV-2-mNG) was received from the World Reference Center for Emerging Viruses and Arboviruses at the University of Texas Medical Branch after obtaining a material transfer agreement between the two institutions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "mNeonGreen-labeled", "infectious", "clone-derived", "strain", "(", "icSARS-CoV-2-mNG", ")", "was", "received", "from", "the", "World", "Reference", "Center", "for", "Emerging", "Viruses", "and", "Arboviruses", "at", "the", "University", "of", "Texas", "Medical", "Branch", "after", "obtaining", "a", "material", "transfer", "agreement", "between", "the", "two", "institutions", "." ] } ]
PMC11733919	The nanoplatform-mediated cell death modality and related mechanisms are also presented and discussed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "nanoplatform-mediated", "cell", "death", "modality", "and", "related", "mechanisms", "are", "also", "presented", "and", "discussed", "." ] } ]
PMC11760643	The anti‐P2X7 mAb mediated CDC in HEK‐P2X7 and human RPMI 8226 cells but not (non‐transfected) HEK‐293 cells or mouse J774 cells, confirming that this effect required the presence of human P2X7.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "anti‐P2X7", "mAb", "mediated", "CDC", "in", "HEK‐P2X7", "and", "human", "RPMI", "8226", "cells", "but", "not", "(", "non‐transfected", ")", "HEK‐293", "cells", "or", "mouse", "J774", "cells", ",", "confirming", "that", "this", "effect", "required", "the", "presence", "of", "human", "P2X7", "." ] } ]
PMC11462673	D Histogram shows the bioluminescence signal values for both groups of mice at different time points.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "Histogram", "shows", "the", "bioluminescence", "signal", "values", "for", "both", "groups", "of", "mice", "at", "different", "time", "points", "." ] } ]
PMC11394112	The Ct values were normalized to TATA-binding protein (TBP; Taqman, Hs00427620_m1) and compared to the untreated controls to obtain ∆Ct values.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Ct", "values", "were", "normalized", "to", "TATA-binding", "protein", "(", "TBP", ";", "Taqman", ",", "Hs00427620_m1", ")", "and", "compared", "to", "the", "untreated", "controls", "to", "obtain", "∆Ct", "values", "." ] } ]
PMC11476837	The data are presented as mean ± standard deviation (SD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "are", "presented", "as", "mean", "±", "standard", "deviation", "(", "SD", ")", "." ] } ]
PMC11462673	Effective dose-dependent degradation of MYB was observed in both 6 T-CEM and J.gamma1 cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Effective", "dose-dependent", "degradation", "of", "MYB", "was", "observed", "in", "both", "6", "T-CEM", "and", "J.gamma1", "cell", "lines", "." ] } ]
PMC11739504	The results suggest that the loss of Kat2b caused a delay in ciliogenesis and reduced the acetylation of α-tubulin through its acetyltransferase activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "suggest", "that", "the", "loss", "of", "Kat2b", "caused", "a", "delay", "in", "ciliogenesis", "and", "reduced", "the", "acetylation", "of", "α-tubulin", "through", "its", "acetyltransferase", "activity", "." ] } ]
PMC10955424	The levels of cPARP were evaluated by immunoblotting and quantified by densitometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "levels", "of", "cPARP", "were", "evaluated", "by", "immunoblotting", "and", "quantified", "by", "densitometry", "." ] } ]
PMC11745600	These mice developed diabetes from approximately 4 wk of age because of increased degradation of proinsulin and insulin mutant proteins and pancreatic β-cell depletion resulting from reduced proliferation and increased apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "mice", "developed", "diabetes", "from", "approximately", "4", "wk", "of", "age", "because", "of", "increased", "degradation", "of", "proinsulin", "and", "insulin", "mutant", "proteins", "and", "pancreatic", "β-cell", "depletion", "resulting", "from", "reduced", "proliferation", "and", "increased", "apoptosis", "." ] } ]
PMC11731161	We examined the expression levels of USP7 in both SEL-sensitive and SEL-insensitive cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "examined", "the", "expression", "levels", "of", "USP7", "in", "both", "SEL-sensitive", "and", "SEL-insensitive", "cells", "." ] } ]
PMC11743316	Akt stimulation is a key modulator in the PI3K pathway that promotes the proliferation of cells while suppressing apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Akt", "stimulation", "is", "a", "key", "modulator", "in", "the", "PI3", "K", "pathway", "that", "promotes", "the", "proliferation", "of", "cells", "while", "suppressing", "apoptosis", "." ] } ]
PMC7039683	Figure 5—figure supplement 1.Concordance of replicates of mouse embryonic palatal epithelium ATAC-seq.(A) Correlation of three biological replicates of E14.5 mouse palate epithelium and mesenchyme ATAC-seq results. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "5—figure", "supplement", "1.Concordance", "of", "replicates", "of", "mouse", "embryonic", "palatal", "epithelium", "ATAC-seq.(A", ")", "Correlation", "of", "three", "biological", "replicates", "of", "E14.5", "mouse", "palate", "epithelium", "and", "mesenchyme", "ATAC-seq", "results", ".", "(" ] } ]
PMC9429973	Based on our data, clinicians should be alert about GVHD markers while treating HCT relapsed patients with CAR-T therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "our", "data", ",", "clinicians", "should", "be", "alert", "about", "GVHD", "markers", "while", "treating", "HCT", "relapsed", "patients", "with", "CAR-T", "therapy", "." ] } ]
PMC9429973	1 CLL patient did not engraft and had SD at month 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1", "CLL", "patient", "did", "not", "engraft", "and", "had", "SD", "at", "month", "1", "." ] } ]
PMC8097906	The solvent (0.1% DMSO for lupeol and 0.1% CHCl3 for ß-sitosterol) was used as negative control and set to 100%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "solvent", "(", "0.1", "%", "DMSO", "for", "lupeol", "and", "0.1", "%", "CHCl3", "for", "ß-sitosterol", ")", "was", "used", "as", "negative", "control", "and", "set", "to", "100", "%", "." ] } ]
PMC10114490	Red line marks FDR = 0.05 Dox-induced hepatocyte-like cells, i.e., diHLC, diHLC-LT and diHLC-T (Fig. 1A), were obtained by culturing iHDF, iHDF-LT and iHDF-T, respectively, in hepatocyte maturation media (HMM) containing 250 ng/mL Dox for 12 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Red", "line", "marks", "FDR", "=", "0.05", "Dox-induced", "hepatocyte-like", "cells", ",", "i.e.", ",", "diHLC", ",", "diHLC-LT", "and", "diHLC-T", "(", "Fig.", "1A", ")", ",", "were", "obtained", "by", "culturing", "iHDF", ",", "iHDF-LT", "and", "iHDF-T", ",", "respectively", ",", "in", "hepatocyte", "maturation", "media", "(", "HMM", ")", "containing", "250", "ng/mL", "Dox", "for", "12", "days", "." ] } ]
PMC11569208	Next steps for this experimental series would be to validate and clone several other PP targets into VSV and test their impact on OV infectivity and oncolysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", "steps", "for", "this", "experimental", "series", "would", "be", "to", "validate", "and", "clone", "several", "other", "PP", "targets", "into", "VSV", "and", "test", "their", "impact", "on", "OV", "infectivity", "and", "oncolysis", "." ] } ]
PMC11551844	Marine sponges and their associated microorganisms have contributed the majority of natural products displaying pharmacological activities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Marine", "sponges", "and", "their", "associated", "microorganisms", "have", "contributed", "the", "majority", "of", "natural", "products", "displaying", "pharmacological", "activities", "." ] } ]
PMC11095939	Therefore, Mecp2 OE negatively regulates quiescence exit in hepatocytes after PHx.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "Mecp2", "OE", "negatively", "regulates", "quiescence", "exit", "in", "hepatocytes", "after", "PHx", "." ] } ]
PMC8662250	These experimental outcomes suggested that CBD, acting at the PPAR‐γ site, can interfere with inflammasome complex formation, preventing the release of propyroptotic mediators and rescuing cells viability (Yang et al., 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "experimental", "outcomes", "suggested", "that", "CBD", ",", "acting", "at", "the", "PPAR‐γ", "site", ",", "can", "interfere", "with", "inflammasome", "complex", "formation", ",", "preventing", "the", "release", "of", "propyroptotic", "mediators", "and", "rescuing", "cells", "viability", "(", "Yang", "et", "al.", ",", "2021", ")", "." ] } ]
PMC10914904	OAS1 can bind to the apical stem-loop region (40–50 nt) of vtRNA 2-1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "OAS1", "can", "bind", "to", "the", "apical", "stem-loop", "region", "(", "40–50", "nt", ")", "of", "vtRNA", "2", "-", "1", "." ] } ]
PMC11790971	The whole dataset consisted of 27,929 individual cells segmented from 804 FOVs across the three passages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "whole", "dataset", "consisted", "of", "27,929", "individual", "cells", "segmented", "from", "804", "FOVs", "across", "the", "three", "passages", "." ] } ]
PMC11682525	Expression of nestin D) and SOX10 (E) by in vitro cultured HFSCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "of", "nestin", "D", ")", "and", "SOX10", "(", "E", ")", "by", "in", "vitro", "cultured", "HFSCs", "." ] } ]
PMC7582629	The Raman spectrum of cytoplasm shows a high content of proteins and carbohydrates, which appear, to a lesser extent, between 1300–1350 and 1400–1500 cm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Raman", "spectrum", "of", "cytoplasm", "shows", "a", "high", "content", "of", "proteins", "and", "carbohydrates", ",", "which", "appear", ",", "to", "a", "lesser", "extent", ",", "between", "1300–1350", "and", "1400–1500", "cm", "." ] } ]
PMC11247842	On BTA14, the QTL was detected using MTAG_CM but not using MTAG_SCS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "BTA14", ",", "the", "QTL", "was", "detected", "using", "MTAG_CM", "but", "not", "using", "MTAG_SCS", "." ] } ]
PMC11754094	Thus, inosine excision by eMPG of AYBE probably enables DSB generation and large deletions, similar to CGBE1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "inosine", "excision", "by", "eMPG", "of", "AYBE", "probably", "enables", "DSB", "generation", "and", "large", "deletions", ",", "similar", "to", "CGBE1", "." ] } ]
PMC11765988	A recent analysis reported that 2.2% of the sarcoidosis patients developed hematologic malignancies, with 1.5% developing non-Hodgkin’s lymphoma and 0.3% developing Hodgkin’s lymphoma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "recent", "analysis", "reported", "that", "2.2", "%", "of", "the", "sarcoidosis", "patients", "developed", "hematologic", "malignancies", ",", "with", "1.5", "%", "developing", "non-Hodgkin", "’s", "lymphoma", "and", "0.3", "%", "developing", "Hodgkin", "’s", "lymphoma", "." ] } ]
PMC10873328	But TGFBI was significantly higher in HIF-2α-overexpressed cells (Fig. 2d).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "But", "TGFBI", "was", "significantly", "higher", "in", "HIF-2α-overexpressed", "cells", "(", "Fig.", "2d", ")", "." ] } ]
PMC6337547	Therefore, elucidation of the conversion pathway of phenolic acid, particularly identifying key enzymes involved in transformation, and in-depth study of the biotransformation mechanism would promote the production and development of new phenolic acids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "elucidation", "of", "the", "conversion", "pathway", "of", "phenolic", "acid", ",", "particularly", "identifying", "key", "enzymes", "involved", "in", "transformation", ",", "and", "in-depth", "study", "of", "the", "biotransformation", "mechanism", "would", "promote", "the", "production", "and", "development", "of", "new", "phenolic", "acids", "." ] } ]
PMC11720808	This work contributes to identification of a novel chemotherapeutic drug and reveals a crucial mechanism for OS treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "work", "contributes", "to", "identification", "of", "a", "novel", "chemotherapeutic", "drug", "and", "reveals", "a", "crucial", "mechanism", "for", "OS", "treatment", "." ] } ]
PMC9479186	Every 24 h, one plate was taken randomly and 20 μl of MTT (5 mg/ml, Genview) was added to each well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Every", "24", "h", ",", "one", "plate", "was", "taken", "randomly", "and", "20", "μl", "of", "MTT", "(", "5", "mg/ml", ",", "Genview", ")", "was", "added", "to", "each", "well", "." ] } ]
PMC6835428	However, particles in the nm range are more suited to crossing cell membranes compared to μm particles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "particles", "in", "the", "nm", "range", "are", "more", "suited", "to", "crossing", "cell", "membranes", "compared", "to", "μm", "particles", "." ] } ]
PMC9429973	The median age in these 9 patients was 57 years (range 34 to 63 years).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "median", "age", "in", "these", "9", "patients", "was", "57", "years", "(", "range", "34", "to", "63", "years", ")", "." ] } ]
PMC11536589	We sampled mouse tumors and examined the protein levels of MGST1 and Ki67 by immunohistochemical staining (IHC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "sampled", "mouse", "tumors", "and", "examined", "the", "protein", "levels", "of", "MGST1", "and", "Ki67", "by", "immunohistochemical", "staining", "(", "IHC", ")", "." ] } ]
PMC11627133	SpyRho lights up upon binding to the aptamer, RhoBAST.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SpyRho", "lights", "up", "upon", "binding", "to", "the", "aptamer", ",", "RhoBAST", "." ] } ]
PMC11696659	The results show that patients with lung cancer and COPD present the longest telomere lengths in all percentiles and patients with COPD the shortest (Fig. 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "show", "that", "patients", "with", "lung", "cancer", "and", "COPD", "present", "the", "longest", "telomere", "lengths", "in", "all", "percentiles", "and", "patients", "with", "COPD", "the", "shortest", "(", "Fig.", "1A", ")", "." ] } ]
PMC11765678	Cancer cells are more vulnerable to iron toxicity due to high dependency on iron metabolism than noncancerous cells, making cancer cells more vulnerable to ferroptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancer", "cells", "are", "more", "vulnerable", "to", "iron", "toxicity", "due", "to", "high", "dependency", "on", "iron", "metabolism", "than", "noncancerous", "cells", ",", "making", "cancer", "cells", "more", "vulnerable", "to", "ferroptosis", "." ] } ]
PMC11519583	f MPs, transfected with the indicated siRNAs, were visualized using Oil Red O staining at 6 days after induction of adipogenic differentiation (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "f", "MPs", ",", "transfected", "with", "the", "indicated", "siRNAs", ",", "were", "visualized", "using", "Oil", "Red", "O", "staining", "at", "6", "days", "after", "induction", "of", "adipogenic", "differentiation", "(", "n", "=", "3", ")", "." ] } ]
PMC6133382	The ability of the MGAT1 CHO cell line to limit glycosylation to early intermediates in the N-linked glycosylation pathway without impairing the doubling time or ability to grow at high cell densities suggests that it will be a useful substrate for the biopharmaceutical production of HIV-1 vaccine immunogens.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ability", "of", "the", "MGAT1", "CHO", "cell", "line", "to", "limit", "glycosylation", "to", "early", "intermediates", "in", "the", "N-linked", "glycosylation", "pathway", "without", "impairing", "the", "doubling", "time", "or", "ability", "to", "grow", "at", "high", "cell", "densities", "suggests", "that", "it", "will", "be", "a", "useful", "substrate", "for", "the", "biopharmaceutical", "production", "of", "HIV-1", "vaccine", "immunogens", "." ] } ]
PMC11496728	The three cell lines of CHO-WT and CHO-KO were expanded and cultured in a serum-free suspension medium for 7 days.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "three", "cell", "lines", "of", "CHO-WT", "and", "CHO-KO", "were", "expanded", "and", "cultured", "in", "a", "serum-free", "suspension", "medium", "for", "7", "days", "." ] } ]
PMC9436459	Overall, palodesangrens D dimethyl ether and B trimethyl ether were successfully obtained for the first time via this strategy over nine steps starting from the Diels−Alder reactions .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", ",", "palodesangrens", "D", "dimethyl", "ether", "and", "B", "trimethyl", "ether", "were", "successfully", "obtained", "for", "the", "first", "time", "via", "this", "strategy", "over", "nine", "steps", "starting", "from", "the", "Diels−Alder", "reactions", "." ] } ]
PMC11023271	Adams et al. reported that serum treatment led to reduction of RIPK4 mRNA in HaCaT cells , an immortalized keratinocyte cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Adams", "et", "al.", "reported", "that", "serum", "treatment", "led", "to", "reduction", "of", "RIPK4", "mRNA", "in", "HaCaT", "cells", ",", "an", "immortalized", "keratinocyte", "cell", "line", "." ] } ]
PMC11626627	The RNA sequencing expression profiles and survival information for patients with ccRCC in TCGA (https://tcga-data.nci.nih.gov/tcga/, accessed on 12 July 2022) database were obtained from UCSC Xena data portal (https://xenabrowser.net/, accessed on 15 July 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "RNA", "sequencing", "expression", "profiles", "and", "survival", "information", "for", "patients", "with", "ccRCC", "in", "TCGA", "(", "https://tcga-data.nci.nih.gov/tcga/", ",", "accessed", "on", "12", "July", "2022", ")", "database", "were", "obtained", "from", "UCSC", "Xena", "data", "portal", "(", "https://xenabrowser.net/", ",", "accessed", "on", "15", "July", "2022", ")", "." ] } ]
PMC9250505	The use of EOC cell line and patient-derived organoids and xenografts further demonstrated the efficacy of the NPB-PARPi combination.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "use", "of", "EOC", "cell", "line", "and", "patient-derived", "organoids", "and", "xenografts", "further", "demonstrated", "the", "efficacy", "of", "the", "NPB-PARPi", "combination", "." ] } ]
PMC3122064	To investigate the importance of the MDM2–p53 complex formation in preventing apoptosis in TC, we have used the small molecule inhibitors ‘reactivation of p53 and induction of tumours cell apoptosis' (RITA) and Nutlin-3 that are supposed to disrupt the MDM2–p53 interaction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "investigate", "the", "importance", "of", "the", "MDM2–p53", "complex", "formation", "in", "preventing", "apoptosis", "in", "TC", ",", "we", "have", "used", "the", "small", "molecule", "inhibitors", "‘", "reactivation", "of", "p53", "and", "induction", "of", "tumours", "cell", "apoptosis", "'", "(", "RITA", ")", "and", "Nutlin-3", "that", "are", "supposed", "to", "disrupt", "the", "MDM2–p53", "interaction", "." ] } ]
PMC8382973	According to the latest global statistics report, 38 million individuals are living with HIV (1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "the", "latest", "global", "statistics", "report", ",", "38", "million", "individuals", "are", "living", "with", "HIV", "(", "1", ")", "." ] } ]
PMC11033180	Data are mean ± SEM, with at least n = 10 neurons per condition (except spontaneous firing Fc n = 9 and Sema5A-Fc n = 5) from 3 independent experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "mean", "±", "SEM", ",", "with", "at", "least", "n", "=", "10", "neurons", "per", "condition", "(", "except", "spontaneous", "firing", "Fc", "n", "=", "9", "and", "Sema5A-Fc", "n", "=", "5", ")", "from", "3", "independent", "experiments", "." ] } ]
PMC11401350	Further, T cells were surface stained for CD8 and hCD34 followed by staining for CD69.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", ",", "T", "cells", "were", "surface", "stained", "for", "CD8", "and", "hCD34", "followed", "by", "staining", "for", "CD69", "." ] } ]
PMC11224020	Data are representative of two independent experiments (n = 33 cells in 4 µm; n = 43 cells in 3 µm).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "representative", "of", "two", "independent", "experiments", "(", "n", "=", "33", "cells", "in", "4", "µm", ";", "n", "=", "43", "cells", "in", "3", "µm", ")", "." ] } ]
PMC11085211	In agreement with this, doxorubicin significantly impaired PBMC viability, similarly to FR2A clusters (Figure 9b), supporting the hypothesis that phytochemicals in the FR2A clusters could have chemotherapeutic properties.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "agreement", "with", "this", ",", "doxorubicin", "significantly", "impaired", "PBMC", "viability", ",", "similarly", "to", "FR2A", "clusters", "(", "Figure", "9b", ")", ",", "supporting", "the", "hypothesis", "that", "phytochemicals", "in", "the", "FR2A", "clusters", "could", "have", "chemotherapeutic", "properties", "." ] } ]
PMC11597291	All nCGO-PEG particles caused less than 5% hemolysis, even at a relatively high concentration of 1 mg/mL. This result, taken together with the lack of cytotoxicity of the nCGO-PEG particles (Figure 5), suggests the biocompatibility of the nCGO-PEG nanocarrier.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "nCGO-PEG", "particles", "caused", "less", "than", "5", "%", "hemolysis", ",", "even", "at", "a", "relatively", "high", "concentration", "of", "1", "mg/mL.", "This", "result", ",", "taken", "together", "with", "the", "lack", "of", "cytotoxicity", "of", "the", "nCGO-PEG", "particles", "(", "Figure", "5", ")", ",", "suggests", "the", "biocompatibility", "of", "the", "nCGO-PEG", "nanocarrier", "." ] } ]
PMC11585994	Alterations in the RNA expression levels were assessed using Real-time quantitative reverse transcription polymerase chain reaction kits (TIANGEN, FP215) utilizing the Bio-Rad fluorescence quantitative PCR system and BioRad CFX Manager software.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Alterations", "in", "the", "RNA", "expression", "levels", "were", "assessed", "using", "Real-time", "quantitative", "reverse", "transcription", "polymerase", "chain", "reaction", "kits", "(", "TIANGEN", ",", "FP215", ")", "utilizing", "the", "Bio-Rad", "fluorescence", "quantitative", "PCR", "system", "and", "BioRad", "CFX", "Manager", "software", "." ] } ]
PMC11687167	Many clinical trials of monoclonal antibodies against PCSK9, including evolocumab and alirocumab, have been reported [23–25].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Many", "clinical", "trials", "of", "monoclonal", "antibodies", "against", "PCSK9", ",", "including", "evolocumab", "and", "alirocumab", ",", "have", "been", "reported", "[", "23–25", "]", "." ] } ]
PMC11643491	The oil temperature was measured with an infrared camera and maintained between 55 and 65 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "oil", "temperature", "was", "measured", "with", "an", "infrared", "camera", "and", "maintained", "between", "55", "and", "65", "°", "C", "." ] } ]
PMC11036064	The obtained ct values were analyzed using log10 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "obtained", "ct", "values", "were", "analyzed", "using", "log10", "2", "." ] } ]
PMC11656657	For the cell lines with high expression of GD2, namely 143B (OS) and RD (ERMS) cell lines, we decided to challenge further the system by applying different E:T ratio in both two-dimensional (2D) and three-dimensional (3D) culture models (Supplemental Fig. 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "cell", "lines", "with", "high", "expression", "of", "GD2", ",", "namely", "143B", "(", "OS", ")", "and", "RD", "(", "ERMS", ")", "cell", "lines", ",", "we", "decided", "to", "challenge", "further", "the", "system", "by", "applying", "different", "E", ":", "T", "ratio", "in", "both", "two-dimensional", "(", "2D", ")", "and", "three-dimensional", "(", "3D", ")", "culture", "models", "(", "Supplemental", "Fig.", "6", ")", "." ] } ]
PMC11377827	To examine this further, we generated mixed knockout (KO) populations of USP43 using sgRNA in HeLa, A549, and MCF7 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "To", "examine", "this", "further", ",", "we", "generated", "mixed", "knockout", "(", "KO", ")", "populations", "of", "USP43", "using", "sgRNA", "in", "HeLa", ",", "A549", ",", "and", "MCF7", "cells", "." ] } ]
PMC11644761	In forskolin-treated cells, both pterostilbene 10 μM and 100 μM caused the hypermethylation of the global DNA methylation pattern, similarly to replicative cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "forskolin-treated", "cells", ",", "both", "pterostilbene", "10", "μM", "and", "100", "μM", "caused", "the", "hypermethylation", "of", "the", "global", "DNA", "methylation", "pattern", ",", "similarly", "to", "replicative", "cells", "." ] } ]
PMC11786767	Scale bars represent (A) 5 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", "represent", "(", "A", ")", "5", "μm", "." ] } ]
PMC9792775	Therefore, it is of great significance to enhance the sensitivity of PTX and find effective clinical treatments to improve clinical effectiveness for sarcoma patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "it", "is", "of", "great", "significance", "to", "enhance", "the", "sensitivity", "of", "PTX", "and", "find", "effective", "clinical", "treatments", "to", "improve", "clinical", "effectiveness", "for", "sarcoma", "patients", "." ] } ]
PMC11656048	Shikonin is the major bioactive component extracted from the roots of lithospermum erythrorhizon which is also known as “Zicao” in traditional Chinese medicine (TCM) (Guo et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Shikonin", "is", "the", "major", "bioactive", "component", "extracted", "from", "the", "roots", "of", "lithospermum", "erythrorhizon", "which", "is", "also", "known", "as", "“", "Zicao", "”", "in", "traditional", "Chinese", "medicine", "(", "TCM", ")", "(", "Guo", "et", "al.", ",", "2019", ")", "." ] } ]
PMC11541409	Annals of Oncology, 2022.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Annals", "of", "Oncology", ",", "2022", "." ] } ]
PMC10577955	B Bar chart showing the percentage of cell population in each phase of the cell cycle analysis. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Bar", "chart", "showing", "the", "percentage", "of", "cell", "population", "in", "each", "phase", "of", "the", "cell", "cycle", "analysis", ".", "*" ] } ]

PMC11803149

Eight days later, young and aged OT-I TCR-T cells were adoptively transferred into young and aged tumor-bearing mice, respectively (A) or into young tumor-bearing mice (B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Eight", "days", "later", ",", "young", "and", "aged", "OT-I", "TCR-T", "cells", "were", "adoptively", "transferred", "into", "young", "and", "aged", "tumor-bearing", "mice", ",", "respectively", "(", "A", ")", "or", "into", "young", "tumor-bearing", "mice", "(", "B", ")", "." ] } ]

PMC10197932

To evaluate this hypothesis, we also analyzed GSH content after 30 min post-US treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "evaluate", "this", "hypothesis", ",", "we", "also", "analyzed", "GSH", "content", "after", "30", "min", "post-US", "treatment", "." ] } ]

PMC11665584

Macrophage 2 was enriched for Spp1, a marker of another antiinflammatory macrophage subpopulation (34).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Macrophage", "2", "was", "enriched", "for", "Spp1", ",", "a", "marker", "of", "another", "antiinflammatory", "macrophage", "subpopulation", "(", "34", ")", "." ] } ]

PMC9275501

Angelica polysaccharide (ASP) could protect bone marrow stromal cells from 5-FU chemotherapy damage (Xiao et al., 2017).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Angelica", "polysaccharide", "(", "ASP", ")", "could", "protect", "bone", "marrow", "stromal", "cells", "from", "5-FU", "chemotherapy", "damage", "(", "Xiao", "et", "al.", ",", "2017", ")", "." ] } ]

PMC8759873

However, how to transfer the VHL gene safely, efficiently, specifically, and stably to tumor target cells for gene therapy is an urgent problem to be solved.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "how", "to", "transfer", "the", "VHL", "gene", "safely", ",", "efficiently", ",", "specifically", ",", "and", "stably", "to", "tumor", "target", "cells", "for", "gene", "therapy", "is", "an", "urgent", "problem", "to", "be", "solved", "." ] } ]

PMC11727000

The target-decoy-based false discovery rate (FDR) filter for spectrum and protein identification was set to 1%.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "target-decoy-based", "false", "discovery", "rate", "(", "FDR", ")", "filter", "for", "spectrum", "and", "protein", "identification", "was", "set", "to", "1", "%", "." ] } ]

PMC10606998

For low-grade gliomas, long-term survival exceeds 90%.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "low-grade", "gliomas", ",", "long-term", "survival", "exceeds", "90", "%", "." ] } ]

PMC6835428

Another target able to induce chemo-resistance is the Focal adhesion kinase (FAK).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "target", "able", "to", "induce", "chemo-resistance", "is", "the", "Focal", "adhesion", "kinase", "(", "FAK", ")", "." ] } ]

PMC10654497

Importantly, our approach may be helpful in analyzing variations in the immune microenvironment among various patients with adenocarcinoma. "

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Importantly", ",", "our", "approach", "may", "be", "helpful", "in", "analyzing", "variations", "in", "the", "immune", "microenvironment", "among", "various", "patients", "with", "adenocarcinoma", ".", "\"" ] } ]

PMC8009078

Due to its fast in execution, trustworthy and ease to use, molecular docking has become favorable to the wider community of researchers from academia and industry.

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PMC11762280

ZBP1, also known as DNA-dependent activator of IRFs (DAI), was originally found to be strongly induced by IFN-γ or lipopolysaccharide (LPS) and to play an important role in DNA-mediated activation of innate immunity .

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PMC11684297

In our recent study, we have shown that ZnO nanosheets also exhibited anticancer activity against A549 and A375 cells .

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PMC11224020

Data were analyzed by multiple unpaired Student’s t-tests; ***P = 0.0001; ****P < 0.0001.

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PMC11742231

Recent advancements in graph neural networks (GNNs) have shown great promise in drug response prediction by effectively modeling the intricate relationships between drugs and cancer cell lines.

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PMC11530949

The biosynthesized Ag-doped CuO NPs, in particular, demonstrated superior cytotoxic efficiency, likely due to the additional benefits of the plant-derived capping and stabilizing agents that enhance the NPs' stability and biocompatibility (59, 60).

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PMC9516401

T2DM arises from unacceptable insulin levels and/or improper responses to this hormone that controls blood sugar levels.

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PMC11676169

The BCAT1-binding region of KU80 was similarly determined using HA-tagged KU80 full-length protein and deletion mutants (aa 1–240; aa 241–550; aa 551–732).

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PMC10988555

Data acquisition, integration, and handling were made resorting to the software package EAGER-200 (Carlo Erba Instruments).

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PMC10956161

Several studies have found similar results in lung cancer.

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PMC9429973

Aims: The aim of this work was to characterize the immune cell composition of blood and BM samples from CCUS/MDS patients and investigate the presence of circulating anti-Treg cells in blood samples and their reactivity towards immunogenic peptides.

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PMC11001582

After approximately 24 h, 600 ng ml puromycin was applied for a further 48 h to allow transient selection.

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PMC11715644

While wild-type MCF10A cells migrated faster in narrow channels, this confinement sensitivity was reduced after +ErbB2 mutation or with constitutively active RhoA. This physical interpretation of collective cell migration as density and shape transitions in granular matter could advance our understanding of complex living systems.

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PMC11768281

This understanding suggests enhancing co-stimulatory molecules and blocking co-inhibitory pathways.

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PMC11429241

TWIST1 encodes a transcription factor that regulates the process, promoting the downregulation of CDH1 and rgw upregulation of CDH2, where epithelial cells lose their cell–cell adhesion properties (mediated by E-cadherin) and gain migratory and invasive properties (mediated by N-cadherin) .

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PMC11731614

Another differentially expressed pathway was ‘Neurotransmitter Secretion’ (Fig. 3G right; adjusted p-value ≤ 0.05), consistent with the physical localization of DRG nerve afferents, which tunnel through the keratinocyte cytoplasm to form synapse-like contacts (Talagas, 2020, Erbacher, 2024).Fig.

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PMC9341513

On the other hand, there is some interaction between the insert and LTO1.

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PMC11633763

To confirm this hypothesis, we examined the effects of USP22 knockdown and overexpression on the expression of HK2 and β‐catenin in 143B cells.

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PMC11640247

Visualization of the corpus callosum at P0 showed significantly delayed axonal extension in RAC3-R66W-expressing neurons compared to controls (Figure 5A,B).

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PMC3734024

To understand how FasL B cells relate to previously-identified B cell subsets, we compared surface expression of several B cell subset markers in FasL and FasL B cells.

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PMC11025866

Within the group of cells exposed to any HDACi, gene expression in cells treated with NaB, VPA, or NaB+VPA were the most similar and the gene expression pattern within each group of replicates were more similar to each other than between two replicates with identical conditions.

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PMC9429973

In this study, we retrospectively analyzed 417 newly diagnosed primary MDS cases in our hospital and to compare the clinical characteristics, prognosis and gene mutations of the two group patients with or without myelofibrosis.

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PMC11400680

Sphericity of segmented cells and nuclei. (

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PMC11564322

The data are expressed as means ± SD of three independent experiments, each of which consisted of six replicates per treatment group. *

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PMC9429973

A patient with a previous AIHA, relapsed as immune thrombocytopenic purpura during pregnancy.

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PMC11087766

Infections with all of these mutant phages appeared to progress normally and still concentrate sfGFP-tagged PhiKZ nuclear proteins (SI Appendix, Fig. S3), suggesting that import of endogenous phage proteins is not strongly affected by these point mutations.

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PMC11792888

Therefore, natural products show varying synergistic mechanisms to enhance the anticancer effects of etoposide.

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PMC9318744

An mNeonGreen-labeled infectious clone-derived strain (icSARS-CoV-2-mNG) was received from the World Reference Center for Emerging Viruses and Arboviruses at the University of Texas Medical Branch after obtaining a material transfer agreement between the two institutions.

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PMC11733919

The nanoplatform-mediated cell death modality and related mechanisms are also presented and discussed.

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PMC11760643

The anti‐P2X7 mAb mediated CDC in HEK‐P2X7 and human RPMI 8226 cells but not (non‐transfected) HEK‐293 cells or mouse J774 cells, confirming that this effect required the presence of human P2X7.

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PMC11462673

D Histogram shows the bioluminescence signal values for both groups of mice at different time points.

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PMC11394112

The Ct values were normalized to TATA-binding protein (TBP; Taqman, Hs00427620_m1) and compared to the untreated controls to obtain ∆Ct values.

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PMC11476837

The data are presented as mean ± standard deviation (SD).

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PMC11462673

Effective dose-dependent degradation of MYB was observed in both 6 T-CEM and J.gamma1 cell lines.

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PMC11739504

The results suggest that the loss of Kat2b caused a delay in ciliogenesis and reduced the acetylation of α-tubulin through its acetyltransferase activity.

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PMC10955424

The levels of cPARP were evaluated by immunoblotting and quantified by densitometry.

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PMC11745600

These mice developed diabetes from approximately 4 wk of age because of increased degradation of proinsulin and insulin mutant proteins and pancreatic β-cell depletion resulting from reduced proliferation and increased apoptosis.

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PMC11731161

We examined the expression levels of USP7 in both SEL-sensitive and SEL-insensitive cells.

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PMC11743316

Akt stimulation is a key modulator in the PI3K pathway that promotes the proliferation of cells while suppressing apoptosis.

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PMC7039683

Figure 5—figure supplement 1.Concordance of replicates of mouse embryonic palatal epithelium ATAC-seq.(A) Correlation of three biological replicates of E14.5 mouse palate epithelium and mesenchyme ATAC-seq results. (

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PMC9429973

Based on our data, clinicians should be alert about GVHD markers while treating HCT relapsed patients with CAR-T therapy.

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PMC9429973

1 CLL patient did not engraft and had SD at month 1.

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PMC8097906

The solvent (0.1% DMSO for lupeol and 0.1% CHCl3 for ß-sitosterol) was used as negative control and set to 100%.

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PMC10114490

Red line marks FDR = 0.05 Dox-induced hepatocyte-like cells, i.e., diHLC, diHLC-LT and diHLC-T (Fig. 1A), were obtained by culturing iHDF, iHDF-LT and iHDF-T, respectively, in hepatocyte maturation media (HMM) containing 250 ng/mL Dox for 12 days.

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PMC11569208

Next steps for this experimental series would be to validate and clone several other PP targets into VSV and test their impact on OV infectivity and oncolysis.

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PMC11551844

Marine sponges and their associated microorganisms have contributed the majority of natural products displaying pharmacological activities.

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PMC11095939

Therefore, Mecp2 OE negatively regulates quiescence exit in hepatocytes after PHx.

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PMC8662250

These experimental outcomes suggested that CBD, acting at the PPAR‐γ site, can interfere with inflammasome complex formation, preventing the release of propyroptotic mediators and rescuing cells viability (Yang et al., 2021).

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PMC10914904

OAS1 can bind to the apical stem-loop region (40–50 nt) of vtRNA 2-1.

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PMC11790971

The whole dataset consisted of 27,929 individual cells segmented from 804 FOVs across the three passages.

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PMC11682525

Expression of nestin D) and SOX10 (E) by in vitro cultured HFSCs.

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PMC7582629

The Raman spectrum of cytoplasm shows a high content of proteins and carbohydrates, which appear, to a lesser extent, between 1300–1350 and 1400–1500 cm.

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PMC11247842

On BTA14, the QTL was detected using MTAG_CM but not using MTAG_SCS.

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PMC11754094

Thus, inosine excision by eMPG of AYBE probably enables DSB generation and large deletions, similar to CGBE1.

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PMC11765988

A recent analysis reported that 2.2% of the sarcoidosis patients developed hematologic malignancies, with 1.5% developing non-Hodgkin’s lymphoma and 0.3% developing Hodgkin’s lymphoma .

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PMC10873328

But TGFBI was significantly higher in HIF-2α-overexpressed cells (Fig. 2d).

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PMC6337547

Therefore, elucidation of the conversion pathway of phenolic acid, particularly identifying key enzymes involved in transformation, and in-depth study of the biotransformation mechanism would promote the production and development of new phenolic acids.

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PMC11720808

This work contributes to identification of a novel chemotherapeutic drug and reveals a crucial mechanism for OS treatment.

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PMC9479186

Every 24 h, one plate was taken randomly and 20 μl of MTT (5 mg/ml, Genview) was added to each well.

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PMC6835428

However, particles in the nm range are more suited to crossing cell membranes compared to μm particles.

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PMC9429973

The median age in these 9 patients was 57 years (range 34 to 63 years).

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PMC11536589

We sampled mouse tumors and examined the protein levels of MGST1 and Ki67 by immunohistochemical staining (IHC).

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PMC11627133

SpyRho lights up upon binding to the aptamer, RhoBAST.

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PMC11696659

The results show that patients with lung cancer and COPD present the longest telomere lengths in all percentiles and patients with COPD the shortest (Fig. 1A).

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PMC11765678

Cancer cells are more vulnerable to iron toxicity due to high dependency on iron metabolism than noncancerous cells, making cancer cells more vulnerable to ferroptosis.

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PMC11519583

f MPs, transfected with the indicated siRNAs, were visualized using Oil Red O staining at 6 days after induction of adipogenic differentiation (n = 3).

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PMC6133382

The ability of the MGAT1 CHO cell line to limit glycosylation to early intermediates in the N-linked glycosylation pathway without impairing the doubling time or ability to grow at high cell densities suggests that it will be a useful substrate for the biopharmaceutical production of HIV-1 vaccine immunogens.

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PMC11496728

The three cell lines of CHO-WT and CHO-KO were expanded and cultured in a serum-free suspension medium for 7 days.

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PMC9436459

Overall, palodesangrens D dimethyl ether and B trimethyl ether were successfully obtained for the first time via this strategy over nine steps starting from the Diels−Alder reactions .

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PMC11023271

Adams et al. reported that serum treatment led to reduction of RIPK4 mRNA in HaCaT cells , an immortalized keratinocyte cell line.

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PMC11626627

The RNA sequencing expression profiles and survival information for patients with ccRCC in TCGA (https://tcga-data.nci.nih.gov/tcga/, accessed on 12 July 2022) database were obtained from UCSC Xena data portal (https://xenabrowser.net/, accessed on 15 July 2022).

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PMC9250505

The use of EOC cell line and patient-derived organoids and xenografts further demonstrated the efficacy of the NPB-PARPi combination.

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PMC3122064

To investigate the importance of the MDM2–p53 complex formation in preventing apoptosis in TC, we have used the small molecule inhibitors ‘reactivation of p53 and induction of tumours cell apoptosis' (RITA) and Nutlin-3 that are supposed to disrupt the MDM2–p53 interaction.

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PMC8382973

According to the latest global statistics report, 38 million individuals are living with HIV (1).

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PMC11033180

Data are mean ± SEM, with at least n = 10 neurons per condition (except spontaneous firing Fc n = 9 and Sema5A-Fc n = 5) from 3 independent experiments.

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PMC11401350

Further, T cells were surface stained for CD8 and hCD34 followed by staining for CD69.

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PMC11224020

Data are representative of two independent experiments (n = 33 cells in 4 µm; n = 43 cells in 3 µm).

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PMC11085211

In agreement with this, doxorubicin significantly impaired PBMC viability, similarly to FR2A clusters (Figure 9b), supporting the hypothesis that phytochemicals in the FR2A clusters could have chemotherapeutic properties.

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PMC11597291

All nCGO-PEG particles caused less than 5% hemolysis, even at a relatively high concentration of 1 mg/mL. This result, taken together with the lack of cytotoxicity of the nCGO-PEG particles (Figure 5), suggests the biocompatibility of the nCGO-PEG nanocarrier.

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PMC11585994

Alterations in the RNA expression levels were assessed using Real-time quantitative reverse transcription polymerase chain reaction kits (TIANGEN, FP215) utilizing the Bio-Rad fluorescence quantitative PCR system and BioRad CFX Manager software.

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PMC11687167

Many clinical trials of monoclonal antibodies against PCSK9, including evolocumab and alirocumab, have been reported [23–25].

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PMC11643491

The oil temperature was measured with an infrared camera and maintained between 55 and 65 °C.

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PMC11036064

The obtained ct values were analyzed using log10 2.

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PMC11656657

For the cell lines with high expression of GD2, namely 143B (OS) and RD (ERMS) cell lines, we decided to challenge further the system by applying different E:T ratio in both two-dimensional (2D) and three-dimensional (3D) culture models (Supplemental Fig. 6).

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PMC11377827

To examine this further, we generated mixed knockout (KO) populations of USP43 using sgRNA in HeLa, A549, and MCF7 cells.

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PMC11644761

In forskolin-treated cells, both pterostilbene 10 μM and 100 μM caused the hypermethylation of the global DNA methylation pattern, similarly to replicative cells.

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PMC11786767

Scale bars represent (A) 5 μm.

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PMC9792775

Therefore, it is of great significance to enhance the sensitivity of PTX and find effective clinical treatments to improve clinical effectiveness for sarcoma patients.

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PMC11656048

Shikonin is the major bioactive component extracted from the roots of lithospermum erythrorhizon which is also known as “Zicao” in traditional Chinese medicine (TCM) (Guo et al., 2019).

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PMC11541409

Annals of Oncology, 2022.

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PMC10577955

B Bar chart showing the percentage of cell population in each phase of the cell cycle analysis. *

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