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OTAR3088
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BioData-CellLine_annotated

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PMC11683240
The initial library was generated by a serial combination of cation-exchange chromatography and reversed-phase chromatography from 1000 l human hemofiltrate and consisted of 440 fractions containing a multitude of peptides/proteins (Fig. S1).
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PMC9429973
Results: Data on somatic health status was available for 355 survivors, aged 28-93 years, who participated 5 to 19 years after their AML diagnosis.
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PMC9509578
The phenomenon of MDR is a complex and multifactorial process, illustrated in Fig. 1.
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PMC9318744
Another advantage is that ACE2plusC3 cells are a more homogeneous cell population than either the parental ACE2plus cell line or the commercial IVG-AT cell line.
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PMC11783017
Bing Li: Validation, Formal analysis.
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PMC11047729
Ginsenoside Rg1 (Rg1) is a bioactive substance that can be found in the roots of ginseng (Panax ginseng) and turned white or red ginseng .
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PMC9318744
These data support the use of ACE2plusC3 for monitoring SARS-CoV-2 pseudotyped lentiviral infection.
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PMC11789597
For cell surface protein detection, MM cells were collected and stained with anti‐human CD319‐PE/Cyanine7 (BioLegend, San Diego, CA, USA), anti‐human CD95‐APC/Cyanine7 (BioLegend), anti‐human CD112‐PerCP/Cyanine5.5 (BioLegend), or anti‐human CD325 (CDH2)‐APC (BioLegend).
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PMC9429973
The discovery of novel frontline regimens to decrease chemoresistance and toxicities represents an urgent unmet clinical need for PMBL patients.
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PMC9429973
The study protocol was reviewed and approved by an independent institutional review board.
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PMC5963610
They slow down tumor progression, but they do not increase patients overall survival.
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PMC9509578
The results show increasing interest in the nanomedicine approach to overcome MDR in cancer.
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PMC11593713
The results are presented as Me (Q1; Q3)—median (lower-upper quartile) or M ± SD—mean ± standard deviation.
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PMC11686380
means not significant.
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PMC11764090
High HOS1 expression negatively regulates ICE1 through ubiquitin modification, affecting CBF expression .
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PMC7305184
Three technical replications were made for each group in each experiment.
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PMC10362265
The C74 of human IL18, which was reported to form a novel intermolecular disulfide bond in the human tetrameric assembly, is also located in this short epitope.
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PMC8984067
The principle of PDT for liver cancer cells based on upconversion nanoparticles modified by Ce6 and anti-EpCAM is shown in Scheme 1.
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PMC11665584
While both control and PITX1 keratinocytes expressed Itgb4 at the DEJ, there was a significant increase in Igf1 transcripts in the fibroblasts of the PITX1 skin.
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PMC7369657
The apoptosis rate of 143B cells increased after treatment with high concentration (276 μg/ml) CQDs (Figure 1(f)).
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PMC9504875
RIG-I ubiquitination was suppressed by exogenous expression of N protein, but not that of N ∆N (Figure 5C, lanes 4 and 5, and Figure 5D).
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PMC10213179
Recovered RNA was quantified by qRT-PCR using the Itaq Universal Sybr Green One Step Kit (Bio-Rad, Hercules, CA) and a LightCycler 489 II Thermal Cycler (Roche, Basel, Switzerland).
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PMC11271278
Then a percent enhancer contribution is calculated for each HAPI gene using the following formula for both trans and long-range cis interaction data:[12pt] $$}=})*}}})*})+( 10(})*})+( 10(})*})}$$ Contribution=log10cis OR trans PETs*cis OR trans anchors(log10local PETs*local anchors)+(log10cis PETs*cis anchors)+(log10trans PETs*trans anchors) Using this formula, genes with a higher trans enhancer contribution have a higher number of interacting enhancers and stronger interaction intensity coming from a different chromosome.
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PMC8633974
Subsequently, px333DE plasmid was chemically modified using click chemistry for covalent labelling using Label IT® Nucleic Acid Labeling Kit - Rhodamine-TM (Mirus #MIR4125).
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PMC10366908
Therefore, a class-switched and defucosylated type of EMab-300 could contribute to the treatment of syngenetic mouse tumors and spontaneous mice tumors in the future.
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PMC11547917
Aristolochia sp. plants are used in traditional medicine because of their immunostimulatory and anticarcinogenic properties, despite their content of aristolochic acids (AAs), carcinogenic and nephrotoxic agents.
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PMC8623816
The protoplasts of virus-free strains GD-118 and D122 were prepared using the method described previously by our laboratory .
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PMC11740907
The P5W30-BW-SLNs resulted in a 72.91% increase in survival rates and a reduction in tumor burden by 2.967±0.543%.
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PMC11594074
The RMSD values of the DNMT1–compound complexes relative to the initial docked structure obtained from MOE molecular docking are shown in Figure 4.
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PMC9429973
Median of disease duration was 25.1 months (range, 12.6-765.1).
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PMC11762280
One was for acute UVB exposure, and another one served as a control.
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PMC4270159
This resistance can be overcome with the addition of an appropriate secondary kinase inhibitor.
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PMC11700523
Oxidative stress induced glomerular MR activation through increased MR gene transcription , whereas MR antagonists improved endothelial dysfunction by enhancing the bioavailability of nitric oxide and decreasing superoxide anion levels .
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PMC11648299
The analyses spanned 2001–2019 except for analyses involving BCC, which were analyzed over 2004–2019 due to the establishment of the BCC registry in 2004.
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PMC11790599
So, we first analyzed the impact of TSL on cell cycle progression using TSL-sensitive breast cancer cell lines SK-BR-3, ZR-75–1, and MDA-MB-468, as well as TSL-insensitive cells MDA-MB-231 as models.
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PMC9960565
The results are presented as the mean ± SD (standard deviation).
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PMC11806818
Rahmanian et al. realized electrochemical and fluorescence dual detection of aflatoxin B1 (AFB1) using Fe3O4@AuNPs/ZIF-8 nanocomposites with a large amount of gold surface and aptamer probes.
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PMC9611901
The fibrils are grouped into fibril bundles that form collagen fibres, and the fibres fuse together to form bundles of collagen fibres .
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PMC11486946
In particular, eltrombopag, sorafenib, and verteporfin tended to decrease the total expression level of EGFR, suggesting the internalization and degradation of EGFR.
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PMC11413393
n = 103 cells (DMSO), 104 cells (MMC) and 107 cells (MMC + MS023) (d).
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PMC11612315
f Effects of the intraperitoneal administration of 10 μg/kg exendin 20–29 or 10 μg/kg exendin-4 on blood glucose levels following the administration of 2 g/kg glucose (mean ± S.E.M., n = 5).
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PMC11434983
Two bands due to the counter ion were observed at 556 cm and 833 cm.
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PMC11496491
The VEGF signaling cascade includes PLC-γ pathway, which controls vascular permeability; PI3K/AKT pathway regulates cell survival; The FAK/paxillin pathway is involved in cytoskeletal rearrangement; Ras/MAPK pathway regulates cell proliferation and gene expression.
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PMC10818573
Gene-specific amplification techniques include polymerase chain reaction (PCR) and isothermal amplification.
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PMC11476837
The FITC Annexin V Apoptosis Detection Kit II (BD Biosciences, PA, USA) was used to evaluate the induction of apoptosis using flow cytometry.
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PMC11701801
In addition, rhabdoid tumors, epithelioid sarcoma, ovarian small cell carcinoma, and synovial sarcoma are rare cancers for which promising therapies have not yet been established.
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PMC11411131
It is also fused with a FLAG tag at the amino terminus and an HA tag at the carboxyl terminus.
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PMC11467964
As a result, BMRG expression was closely associated with the prognosis and TME of STS.
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PMC11742670
model MSE for the A-431 cell line.
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PMC11766332
ASD-miRNAs impact various metabolic pathways including steroid biosynthesis, biotin metabolism, fatty acid metabolism and biosynthesis, and lysine degradation .
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PMC10713411
Protein expression of γ-H2AX, ATM, BRCA2, PARP-1, Bcl-2 and LC3I/II in A498 cells with si-NC or si-TRIB3 transfection.
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PMC9622879
Constraint (45) is added to restrict the net energy of the home i to be lower than the energy peak .
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PMC9429973
The treatment effect on ALC counts resolved when KRP203 was stopped on day 111, resulting in blood ALC to pre-HSCT levels.
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PMC8592717
In animal models of PD, PAL improved specific behavioral defects caused by 6-OHDA and MPTP through its neuroprotective pharmacological effects.
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PMC11277157
For example, in HeLa cells, introducing dsRNAs longer than 23 bp induced toxicity and cell death, while shorter RNA fragments did not affect viability.
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PMC9646302
In conclusion, the results of our study demonstrate that LAPTM5 regulates ccRCC development by regulating the RAC1-JNK/p38 signaling cascade.
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PMC11552389
Violin plot of FOXN3 by tumor stage in GEPIA website. (
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PMC11525293
At the highest concentrations of Thal, we did not observe ACE2 downmodulation in the p63-null U-2 OS human osteosarcoma cells.
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PMC9587866
The intermolecular binding energy between ligands and the receptor was -5.8 and -5.9 kcal/mol, whereas inhibitory constant values were 119.59 and 71.80 µM, respectively.
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PMC9429973
In comparison, median overall survival was 40 months in a sex- and age matched background population with newly diagnosed MDS/AML (Fig. 1d).
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PMC11615101
The synovial sarcoma cell line SW982 is a widely used synovial cell line used to mimic the RA-like inflammation in vitro, purchased from the American Type Culture Collection (ATCC), and maintained for five passages.
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PMC11438317
E, Wild type Jurkat cells and cells deficient in LYP (JK 494) transfected with LYP were stimulated with CD3/CD28 antibodies for 15 min and the phosphorylation of Y128 of SLP76, and Y191 of LAT were detected in each condition by IB Regulation of TCR signaling by LYP downstream of ZAP70.
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PMC9429973
22 occurred during induction therapy for AL and 18 during ASCT conditioning regimens.
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PMC9429973
Disease status at enrollment was progressive disease (n=14, 74%), stable disease (n=3, 16%), or partial response (PR; n=2, 11%).
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PMC11371747
A 200 µL sample of the culture medium was taken and the reaction was terminated by addition of TCA (final concentration 5%) and unconverted [5-H]-deoxycytidine was removed by precipitation with activated charcoal as described earlier (Peters et al., 1999; Rots et al., 1999).
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PMC11590870
The specific bioactivity of peptides depends upon their particular amino acid sequence and length .
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PMC9780037
Concerning the cyt c therapeutic delivery systems, many of them are equipped with ligands of proteins that are specifically expressed on cancer cells, to avoid cytotoxic effects in healthy tissue.
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PMC11740508
Decitabine is only incorporated into DNA.
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PMC11531744
To generate more specific OC categories, more categories were required.
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PMC11720808
Data are presented as the mean ± SD (n=5).
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PMC11365983
Consistent with the premise that the mechanistic basis of a proportion of ciliopathies may be unrecognized, the majority identified to date are caused by mutations of major effect that induce severe and pediatric-onset disease.
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PMC11806613
Mechanistically, OST-01 induces ferroptosis by downregulating LRP8-regulated selenoproteins, i.e., GPX4.
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PMC10705095
In the present study, we performed immunoblotting analysis to investigate the expression of HBQ1 in lung adenocarcinoma cell lines A549 and A427.
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PMC11352877
We are aware of the heterogeneity of endometriosis as well as endometrial cancer, which is also reflected in the variability in angiogenesis between the tested cells.
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PMC11769516
All the selected articles were the most relevant ones available for this review.
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PMC11562028
This study would provide a new research strategy based on CD nanomedicine for anti-kidney cancer treatment in the future Scheme 1.
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PMC11409031
Fig. 2 HdWGCNA shows that turquoise, pink, yellow, red, blue, black, and green modules are seven central modules closely related to T cell subsets in OV. (
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PMC10965315
Consistent with this finding, harmaline was reported to have no obvious cytotoxic effect in mouse fibroblast cells (NIH/3T3) (Wang et al., 2015).
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PMC11087301
Expression of SOX2 is associated with higher aggressiveness and poor outcome among CRC patients.
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PMC11092382
Wall.
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PMC11087301
Currently, it has been found that exosomal mesenchymal stem cells inversed EMT through TGF-β1/Smad signaling and induced damaged endometrium repair .
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PMC8097906
Specimens were viewed in a field-emission SEM operated at 5 kV (Merlin VP compact, Carl Zeiss Microscopy, Jena, Germany) and images with a size of 1024 × 768 pixels were recorded.
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PMC11082662
The results from this study are significant, as they demonstrated increased SMPDL3B levels in primary ovarian carcinoma lesion compared to nontumor tissues.
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PMC11705484
Filtering of transcripts with diminished N‐methyladenosine (mA) peaks (MeRIP‐seq data) by transcripts with downregulated expression (RNA‐seq data) in sh‐TRMT61A, compared with sh‐NC, 5637 cells identified 15 transcripts including HMOX2 as targets of TRMT61A. (
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PMC9688728
We assume that the observed phenomenon has a biological basis because the metabolic pathway is a high-dimensional nonlinear system, with members participating in several pathways simultaneously.
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PMC11774747
The requirement for continuous antigen and cytokine stimulations to maintain CAR-VST proliferation further emphasize the importance of the TCR signaling pathway.
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PMC10914904
This effect is likely due to the susceptibility of cells to starvation stress and inactivation of the NF-κB signaling pathway, which increase apoptosis.
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PMC9429973
Image: Summary/Conclusion: To our knowledge, we here present the first description of CH evolution during treatment with lenalidomide-based therapy.
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PMC7553912
WT mice were given intraperitoneal injection of GOx (80 mg/kg) once daily for 3 days.
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PMC9429973
Among the 7 deaths, 6 patients had underlying myelofibrosis, and one pt had polycythemia vera, and all deaths occurred in unvaccinated population except for one death that occurred post vaccination.
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PMC11805741
On the other hand, our molecular docking analysis revealed that zeaxanthin exhibits a higher affinity and lower ΔG compared to obatoclax, the reference drug for BCL-2.
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PMC8592717
The medicinal plants used in traditional Chinese medicines (TCMs) contain the bioactive components PCA and PAL.
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PMC11066331
First two principal components (PC1 and PC2) cover approximately 85 % of total data variability in both the non-centered and median-centered data.
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PMC7802142
To evaluate NV from other nervous tissue cells, we prepared NV by extruding human neuroblastoma SH-SY5Y cells or mouse hippocampal neuronal HT22 cells.
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PMC11515150
After expansion with modified K562 feeder cells, the transduction efficiencies of 12 C CAR-NK and IL-15 CAR-NK cells on day 14 were 67.3% and 30.7%, respectively (Fig. 6b).
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PMC6643347
The effectiveness of the drug in CD4 + T lymphocytes is quite comparable to its effectiveness in macrophages.
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PMC11666785
D Entropy measure (related to randomness) for corrSMLm and SMLM to determine order in the structures and quantify noise.
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PMC9429973
Median durations of post-remission Gr ≥3 neutropenia and FN in VIALE-A were 12.5 d and 8 d (Ven+Aza+G-CSF), and 16 d and 10.5 d (Ven+Aza+non-G-CSF).
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PMC10551595
Healthy peripheral blood mononuclear cells were not affected by concentrations below 13 μM. Further experiments revealed novel findings considering the role of GinA in leukemia management when combined with Dexa.
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PMC6889484
To determine the frequency of A3G-D128K gene reconstitution more precisely, 69 single-cell clones of transduced cells that were selected for puromycin resistance were isolated and analyzed by PCR amplification (Figure 1H).
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