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OTAR3088
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PMC11704135
For instance, two studies evaluated the antimicrobial activity of some newly synthesized pyrimidine derivatives and found that they exhibited significant inhibitory effects against both methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli strains.
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PMC10887351
However, until now, it has not been completely understood if β3-AR is expressed in NB and its role in NB tumor biology; thus, more studies are needed to better understand the mechanisms underlying the complex interaction linking the host immune system and the tumor counterpart in NB.
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PMC11695623
Animal experiments showed that the tumor weight of nude mice decreased significantly after down-regulation of DCUN1D5.
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PMC11525028
Knockdown of ATF4 (ATF4-KD) reduced the transcriptional activity of ASNS, and CARE deletion abolished ASNS promoter induction (Figure 4J).
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PMC11537649
All of this indicated that Lnc NEAT1 can promote cancer progression through a different mechanism.
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PMC10587429
Matrigel Growth Factor Reduced (GFR) Basement Membrane Matrix, LDEV-free (354230, Corning, Corning, NY). -
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PMC10154881
Approval of the research protocol by an Institutional Reviewer Board: N/A. Informed Consent: N/A. Registry and the Regulation No. of study/trial: N/A. Animal study: All mouse experiments were approved by the Experimental Animal Committee of The University of Tokyo (動01‐10).
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PMC8584666
These observations allowed the speculation that GPI-80 expression might augment cell growth or colony formation.
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PMC10926885
The genetic alteration and DNA modification character of NDE1; (A) The frequency and types of NDE1 somatic mutations in pan‐cancer; (B) Alteration frequency of NDE1 in pan‐cancer; (C) The counts and types of NDE1 mutation in pan‐cancer; (D) Effect of NDE1 genetic alterations on progression‐free survival in patients with cancer; (E) The DNA promotor methylation levels of NDE1 in various cancers and normal tissues in TCGA database.
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PMC10587429
For humanized mice bearing tumor, administer 6 μg/animal of IgG or magrolimab on Day 4, 12 μg/animal on Days 12-14, 25 μg/animal on Days 15-17, 50 μg/animal on Days 18-20 and 100 μg/animal on Days 21-22.
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PMC11591794
As a result of statistical analysis, it was determined that the 72-h IC50 value occurred after 25 nM DOX application.
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PMC10654497
Lung cancer exhibits a complicated pathogenesis and is characterized by a high degree of cell heterogeneity; it frequently invades the surrounding tissue and metastasizes.
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PMC11680578
In the combination treatment group, the number of accumulated cells in the sub-G0/G1 phase is lesser than in the RGZ-treated group while the number of cells in the G2/M phase is more in PTX alone compared to PTX + RGZ and control.
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PMC11484188
Subsequently, cell viability following miR-1343-3p upregulation or downregulation was detected using CCK-8 assay.
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PMC11755624
Understanding the signaling pathways regulated by lncRNAs could result in more personalized treatment strategies that will eventually improve patients’ outcomes.
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PMC7519871
In case of NF-kB, both WDL and BA formed 2 hydrogen bonds but the number of other favorable interactions formed by WDL with NF-kB was sufficiently high which accounted for the higher binding affinity of WDL with the receptor.
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PMC11371747
The l-LV-mediated increase in the IC50 values of PLX was most pronounced (between 502 and 4778-fold) when compared to the other two antifolates, while l-LV protection of PMX cytotoxicity was the least (144-211-fold), possibly related to the intrinsic lower sensitivity of these cells to PMX.
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PMC11377827
n = 3 biologically independent samples, mean ± sd.
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PMC11381192
The CSI for each individual was derived according to gene expression values and their regression coefficients in multivariate analysis.
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PMC9412887
In vivo experiments showed that, under mild hyperthermia conditions, F-Pt-NPs exhibited the best antitumor effect with a TIR of 94% with few side effects, further indicating that NIR-triggered mild hyperthermia could reverse CDR.
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PMC11674834
Bioactivation of alkylanilines may be mediated via N-hydroxylation by CYP1A2, followed by O-acetylation by N-acetyltransferase 1 (NAT1) .
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PMC5833712
The etiology of OEC is poorly understood but it is believed that nulliparity, high plasma levels of estrogen or long-term estrogen replacement therapy increases the risk for ovarian cancer, whereas pregnancy, lactation, and oral contraceptives decrease the risk.
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PMC11512230
Their ability to adsorb onto the surface of sarcoma cells and subsequently penetrate them was examined.
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PMC10125312
Hyperthermia is defined as a moderate increase of temperature above physiological values (>37 °C) for defined periods of time.
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PMC11514418
The percentages of CD3+ T cells and CD4+ T cells, the CD4+/CD8+ T cell ratio, and the serum IL-2 level were significantly ameliorated in patients receiving the combined therapy of APS and GS (P < 0.05).
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PMC10809689
Subsequently, membranes were washed thrice with Tris-buffered saline with 0.1% Tween 20 detergent (TBST), and incubated with goat anti-rabbit IgG H&L (HRP) (Abcam, United Kingdom) secondary antibody.
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PMC11453018
The data represent mean ± SEM; *p<0.05, ****p<0.0001 by one-way ANOVA (n=3) The restoration of LMNB1 and P15 expression in iP300w-treated cells delays senescence and induces apoptosis.
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PMC11532793
In every HCC827 sample, all ambiguous reads are probabilistically assigned to transcript HABP2-201, which results in no overdispersion under bootstrap sampling with an estimated RTA-dispersion of 1.00.
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PMC9429973
With its advantage as an oral HMA, OR21 is expected to have future clinical trials as a combination therapy for myeloid malignancies.
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PMC9429973
Surprisingly, machine learning data showed that predictive potential of ncRNAs was stronger than that of PCGs.
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PMC11529598
p < 0.05.
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PMC8735881
The expression of CMI constructs was detected in the cell lysates and culture supernatants of transduced TZM-bl cells by western blotting with an anti-His tag antibody. (
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PMC10955424
Contrary to most of the cirrhosis ascites, the majority of OC ascites confer platinum chemoresistance to OC cells.
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PMC11507371
This circumstance might only allow for a marginal enhancement in response to the additional exogenous oxidative stress induced by CAP.
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PMC8357004
These enzymes remove the acetyl groups resulting in the compacted chromatin and cell cycle regulator gene silencing.
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PMC8973725
It has been recognized that the expression of ZNF family proteins are frequently decreased by DNA methylation in various types of human cancer.
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PMC11306331
Box plots show median, hinges represent 25 and 75 percentiles; whiskers represent 1.5x inter-quartile range (IQR).
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PMC8073654
The rat paw edema induced by carrageenan was also inhibited by 1 with IC50 at 3 h of 22 μmol/paw.
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PMC11564322
An increase in the mTOR mRNA expression was also noted in a human undifferentiated neuroblastoma (SH-SY5Y) cell line after VGVAPG peptide stimulation .
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PMC9739791
However, despite the substantial progress made in the design of efficient Pt(IV) prodrugs, the complexes often lack selectivity towards cancer cells and therapeutic efficiency in vivo, and are prone to hydrolysis in the bloodstream .
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PMC10553685
Mice were monitored for up to 20 weeks with or without estrogen supplemented in the drinking water.
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PMC7229095
By contrast, CDM3 resulted in no growth, even with inoculation at high cell densities (Table 4).Table 4Summary of mini-pool screening resultsCDM1CDM2CDM3Inoculum conditions2000 cells/well1000–4000 cells/well2000–4000 cells/wellTotal wells960448960Growth wells1004320Growth ratio (%)10.496.40Picked wells (> 10 mg/L)321220Picked/Growth ratio (%)3228.20 Summary of mini-pool screening results In the case of CDM1, too many seeded cells may initially display a high growth ratio, but the cells eventually exhibit the shorter longevity after some clones suffer from the damage due to nutrient depletion.
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PMC11467964
At present, the BM, as an ancient cellular matrix, has been found to have certain effects on abundant biological processes.
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PMC11047729
23-Hydroxybetulinic acid is a substance that can be extracted from Pulsatilla chinensis.
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PMC9429973
Results: After induction, CR was achieved in 95 patients (59%).
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PMC10502403
Prior to RNA extraction, NGMCs and NE1-GMCs purified with CD8 microbeads were cultured with or without TCR stimulation, as in metabolomic analysis.
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PMC11612794
These cells were collected, washed with cold PBS twice, suspended in Lysis buffer (20 mM Hepes-NaOH (pH 7.4), 150 mM NaCl, 0.1% NP40, 5 mM 2-mercaptoethanol, 1xcomplete EDTA-free proteinase inhibitor (Roche), and 1xPhosSTOP (SIGMA)) (final: 2x10 cells/mL) and sonicated.
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PMC10142392
The most commonly used method involves using a metal-based catalyst to polymerize ε-caprolactone through a coordination–insertion mechanism (Figure 2) .
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PMC11730311
Results are presented in Table 1 with results from the previous Schild analyses of hαCGRP8-37 and hαCGRP8-37N25K-C20DA-γGlu.
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PMC10745221
Whether there exists a link between methionine addiction and PRMT activity in cancer cells is still unknown, but the results presented here suggest that there is no large-scale direct connection in an osteosarcoma cell line.
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PMC11351758
Then, 1 µL was pipetted from the working solution to pretreat the cells in the medium for 30 min.
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PMC11377827
Mean ± sd.
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PMC11767817
We found that modification in feruloyl moiety with short PEG chains (n = 3) and ether bonds increased cytotoxic activity under hypoxic conditions .
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PMC11188874
The results suggest that treatment with HDAC6 inhibitors preferentially releases HR23B from HDAC6 compared with HR23A.
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PMC8494202
In addition, CKAP2L is reportedly involved in the occurrence and development of other malignant tumors, such as breast and prostate cancers, and is associated with poor prognosis of these cancers .
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PMC11674891
Sequencing was performed on the HiSeq 2500 Sequencing System (Illumina, CA, USA), generating paired-end reads of 101 bp length.
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PMC9985266
DNMT1 is one of the most important DNA methylation transferases .
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PMC9429973
The correlation with the demographic data, comorbidities and complications is ongoing.
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PMC9275501
The researches of carrier-free NDCDS of natural active ingredients and chemotherapy drugs.
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PMC11594074
Among others, EMT processes are modulated by the WNT signaling pathway, which in turn is modulated by methylation patterns and can therefore be influenced by DNMT1 regulation.
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PMC11397654
The 3-(trifluoromethyl)aniline diamide derivative 30b also displayed some levels of activity, but they were lower than those of 30a, 30c and 5-FU.
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PMC11367146
By filtering out compounds that are less likely to be orally active, compounds with a higher probability of success can be selected, thereby reducing attrition rates in drug development .Table 2Drug likeness screening of Vanda tessellata constituent.
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PMC9429973
InO was given as monotherapy in all pts in dose 1,8 mg/m first course and 1,5 mg/m in subsequent (and in 1 case 1,8 mg/m during 2nd cycle without response), but in 1 pt the first course was in combination with mini-hyper-CVD regimen.
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PMC9429973
The clinical characteristics, biological parameters of autografted PBPC and post-infusion outcome of the 55 patients entered this study are reported in Table 1.
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PMC11698348
For skin sample collection, mice were anesthetized with ketamine/xylazine cocktail mixture and then euthanized by cervical dislocation and samples taken at days 0–18 post depilation as described previously for immunofluorescent, and RT-qPCR analysis.
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PMC9429973
In case of MMR loss the TKI dose was increased by +1 level from the dose at which the MMR loss developed.
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PMC11352877
In a hypoxic environment, angiogenic factors bind to their receptor, which is present on the surface of endothelial cells, thereby promoting their dilation and activation .
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PMC6114978
Figure 1A) .
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PMC11087766
However, swapping the C-terminal ~2/3rds (amino acids 66 to 162) or the middle ~1/3 (amino acids 66 to 115) of PhiKZ gp104 into the homologous region of PhiPA3 gp108 caused the chimera to localize to the nucleus during PhiKZ infection (Fig. 1F).
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PMC11768281
Among the studies targeting T cells, 47.6% (30/63) focused on CD4+ T cells, 47.6% (30/63) on CD8+ T cells, 15.8% (10/63) on both CD4+ and CD8+ T cells, and 7.9% (5/63) on γδ T cells.
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PMC11730311
Experiments were performed in duplicates.
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PMC11026382
Taking this enzyme pair as a simplified model system in which to examine a biochemically-mediated epistatic interaction, we create a mathematical model relating variation in DHFR and TYMS catalytic parameters to growth rate using a focused set of well-characterized point mutants.
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PMC11774251
Future research should include larger cohorts, extended treatment periods, and comparative studies with existing psoriasis treatments to fully establish Tan-I’s therapeutic potential.
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PMC6600592
Cyclohexyl (E)-4-hydroxyimino-4-(4-methylphenyl)butanoate (4B-1).
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PMC11587606
Experimental scheme for the induction of RHBDF1 by Dox in acini before and after polarization. (
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PMC11742290
LGR5 was expressed in the crypt base columnar (CBC) cells between the Paneth and base of the crypts .
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PMC11697065
G: Correlation of protein abundance of HC at D0 with the cell specific productivity (qP) from each clonal cell line.
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PMC11206502
To evaluate metabolic rates during increased energy demand, “stress” conditions were induced by the addition of a mix of oligomycin (an ATP synthase inhibitor) and the mitochondrial uncoupler carbonyl cyanide 4-[trifluoromethoxy] phenylhydrazone (FCCP).
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PMC11127909
After cisplatin treatment, the average tumor weight of the 143B-EFHD1 group was decreased by approximately 44% (from 0.84 g to 0.47 g) compared with that of the control group.
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PMC11519788
12 h after cell seeding was defined as the starting point.
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PMC11413393
Taken together, the accumulation of R-loops and the observed broad splicing changes indicate disruption of the function of RNA-binding proteins as a result of PRMT1 inhibition.
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PMC11730000
According to the cell viability assay results, no significant reduction in cell viability was observed in any of the evaluated groups in the comet test compared with the control group (data not shown).
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PMC11750165
Photo were taken with a confocal laser scanning microscope (LSM 510; Carl Zeiss).
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PMC11802929
558 of the 951 putative antigens yielded usable SCT products (Fig. 1b top).
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PMC8956657
Because such highly similar binding patterns were seen for both IMPα2 and IMPα3, we also examined the effect of these interactions across multiple IMPα subfamilies including IMPα1, IMPα3, and IMPα5.
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PMC11461833
The cut-off criteria were p-adj < 0.05 and |log2 FC| > 1.
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PMC10975211
These analogs were designed to retain key attributes such as hydrophobicity and certain structural elements crucial for maintaining antimicrobial efficacy.
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PMC7189327
Furthermore, Li et al. unraveled that the PTPN3 depletion could block the degradation of EGFR, which accelerated cell proliferation and tumorigenicity in lung cancer cells .
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PMC4485786
Short-term culture to study early differentiation events in RMS was accomplished by seeding sarcoma cells at low numbers (4,000 or 8,000 cells/cm) and incubating with DMEM with and without 10 ng/mL tumor necrosis factor (TNF) and 100 ng/mL interferon gamma (IFN-γ).
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PMC11791432
Raw data were obtained and downstream analysis was processed by the Seurat (v 4.0.4) R package .
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PMC5574817
Fig. 1 shows the plasmid map of pCMV6-Neo-hERG (Origene, USA).
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PMC10523483
Quantification of tumor size, tumor number, tumor burden of K (n = 7) and KH (n = 8) lungs. (
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PMC10362265
Periodic boundary conditions and a time-step of 2 fs were applied for all simulations.
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PMC9429973
Results: In total, 4,966 citations were retrieved from the databases; 60 full texts were screened, of which 47 were excluded.
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PMC7553912
The cells in the pellets were resuspended in DMEM supplemented with 2% FCS and used for the analysis of flow cytometry and the isolation of RTECs and renal fibroblasts.
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PMC11087055
See also Video 4 and Figure 4—source data 1.
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PMC8973725
The expression of ZNF677 at different grades and stages of cancer malignancy is shown in Figure 1b–d. To validate the results of the TCGA data, the expression of ZNF677 mRNA and proteins in 60 tumor and 47 normal tissues was examined by qPCR and IHC, respectively.
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PMC11787381
Injection of AβO in the CA1 hippocampal area induced a significant loss of hippocampal neurons 18 days post injury.
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PMC11155445
It was concluded that the metal complex exhibited higher activity than the acyl thiourea ligand which was attributed to the high penetration ability of the complex across the membrane.
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PMC11738017
Circos plot of patient MM-19 based on WGS data.
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