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OTAR3088
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PMC11463018
JAKs, composed of JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2), are a family of intracellular tyrosine kinases that transduce cytokine-mediated signals through the JAK-STAT pathway.
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PMC10723784
Data represent the mean ± SE of n = 4.
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PMC10490530
The potential of hLuz as a reporter protein for non-invasive imaging to follow tumor growth kinetics in mice models was validated.
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PMC11790971
The plate layout design is shown in Fig. S3.
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PMC11746948
f GPX4 detected by immunoblots in A375 cells pre-treated with 2-BP for 24 h, followed by 12 h proteasome inhibitor MG132 treatment.
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PMC11545737
Thus, the appropriate mixture of Yop proteins delivered to the host cell governs its fate.
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PMC10719213
We conclude that T cells have more detectable mitochondrial DNA mutations than B cells, and cladribine has no detectable mutagenic effect on lymphocyte mitochondrial genome nor does it impair mitochondrial function in human T-cell lines.
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PMC8097906
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue tumor and accounts for about 6–8% of all pediatric malignancies .
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PMC7351993
Supplementary Fig. 1 shows pictures of the major components of the RIACS.
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PMC11489275
Finally, a GAMM model (Table 5) was constructed to analyze the dynamic changes of peripheral blood lymphocyte count from 1 to 14 days in patients.
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PMC9429973
Median medullary blast count was 4% (0-19%), and median survival in the entire group was 28 months.
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PMC11026382
pTet-Duet is a low-copy number vector containing two multiple cloning sites; the first is under control of the T7 promoter and the second was modified to be regulated by the tetracycline repressor (TetR).
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PMC11656048
Co-immunoprecipitation and Western blot assay of Nrf2 protein after shikonin and MG132 (2.5 uM) co-treatment 24 h in MG63 and 143B cells. (
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PMC7612475
Cells were seeded at a density of 10,000 cells per mL, and the compound being tested was added at the desired concentrations and vortexed briefly before plating.
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PMC11799620
Thus, this metal becomes a health issue.
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PMC10631132
Gene expression of POU5F1 decreased in all groups significantly from the mesodermal to the hematopoietic stage (A).
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PMC3730428
Chronic inflammation associated with asbestos exposure is strongly linked with initiation and progression of MPM, and a number of studies have established important roles for pro-inflammatory cytokines in MPM tumorigenesis.
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PMC11371627
KEL gene expression was examined by RNA sequencing.
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PMC11703896
No other studies have reported other active sites of rapamycin at present.
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PMC11657695
All these results for KCNA2 at mRNA level were confirmed at protein level using Western blot analysis (Figure S4D).
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PMC5443223
A multi-treatment approach, including chemotherapy, radiation and novel, evolving approaches, such as gene therapy, may provide a more effective palliative and curative result.
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PMC11472569
Moreover, EVs contribute to therapy resistance by influencing the interactions between cancer cells and non-cancer cells within the TME.
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PMC9429973
Using multiomics approaches to study the intracellular signaling pathways in MPNs we recently identified the down regulation of SHP-1 expression in JAK2V617F cells compared to wild type cells.
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PMC9429973
In fact, PICC has been used in autologous patients (93%); 38 of these were multiple myeloma patients.
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PMC11225860
Cell-by-Cell was performed on double thymidine synchronized groups treated with DMSO (B), 1µM alisertib (C), 100µM Aurkin A (D), or a combination 1µM alisertib and 100µM Aurkin A (E).
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PMC10006224
Moreover, next to this loop one can observe the disappearance of a stripe after NIPBL KD (Fig. 5d).
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PMC11463018
All compounds showed comfortable dual inhibition against JAK1 and HDAC6 with IC50 in nanomolar range.
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PMC9960565
TOF-MS (ESI+) m/z calc.
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PMC11474209
It has been found that cyanobacteria abundance and the emergence of cyanoHABs resulted in eutrophication in the lakes of the Azores Islands.
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PMC11680562
During the initial phase of the release experiments, it was noticed that the gel formulations began to release the 5-Fu after they were placed in the release media (Fig. 7A).
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PMC11740907
The present research included the analysis of the percentage of malignant mice that survived under various treatment conditions over a period of 10 days.
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PMC9429973
Grade (G) 3–4 treatment-emergent adverse events (TEAEs) were reported in 25 pts (83%); the most frequent G3–4 TEAEs were neutropenia in 19 (63%), thrombocytopenia in 13 (43%), leukopenia in 12 (40%), anemia in 9 (30%), and decreased lymphocyte count in 9 (30%) pts.
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PMC9118379
Of the 320 spectra, the three OMS tools reported 190–243 spectra having results consistent with conventional protein database searches (Figure 2A).
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PMC11711663
FeaturesLog rank testScore testTraining CIIndependent CI122.25E-041.7E-050.650.6322, 172.50E-052.9E-070.660.6431, 9, 131.46E-091.2E-070.670.5843, 4, 9, 132.73E-092.8E-060.700.6054, 6, 12, 13, 172.68E-095.9E-070.720.6964, 6, 10, 12, 13, 176.76E-091.1E-060.710.6474, 6, 7, 10, 12, 13, 174.77E-091.6E-060.700.6581, 4, 6, 7, 10, 12, 13, 172.68E-098.6E-070.700.67Notably, we use the index in Table 2 to represent features.
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PMC11088135
p < 0.01 vs. control-plasmid group Finally, we investigated the relationship between lncRNA NUTM2A AS1 and YAP1 in human glioma cells.
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PMC7348793
After the transformation of the ligation mix into E. coli GeneHogs (Thermo Fisher Scientific, Waltham, MA, USA), white colonies were picked on plates containing ampicillin (200 mg/mL) and X-gal (40 mg/mL), expanded overnight in TB medium, and used for plasmid DNA extraction (Qiaprep Spin miniprep kit, Qiagen, Germantown, MD, USA).
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PMC11599565
The signature of this cell type is amplified in ovarian carcinoma tumors, suggesting a neuroepithelial origin of this tumor type.
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PMC11628904
In addition to determining the optimal timing for treatment of burn wounds, it is paramount to understand how potential treatment works at the molecular level.
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PMC9847912
Average IC50 values from two or more assay runs ranged from 0.25 to 0.79 nM for the five HIV-1 isolates tested in the CEMss spreading infection assay (Table 1).
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PMC11678841
Adjuvant immunotherapies, designed to address hyper-inflammation, could potentially serve as a therapeutic option to enhance the immune response and alleviate symptoms in patients with VVC.
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PMC9429973
Methods: Systematic search computed in PubMed/Medline, Web of Science and SCOPUS, from the inception of these databases until 28.02.2022, to identify relevant English-written articles.
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PMC11461874
Statistical analysis of the data was performed using one-way ANOVA followed by Dunnett’s test.
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PMC11740508
Results were confirmed in BRCA1/2 intact and deficient xenografts and PDX.
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PMC11345828
All cell lines were cultured at 37 °C with 5% CO2 in a humidified incubator and have been regularly tested negatively for mycoplasm contamination.
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PMC11407042
Thaw the CytoTox 96 Reagent in the dark.
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PMC9429973
The ORR and CR rates was 83 and 79.2%, respectively in this cohort.
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PMC9429973
Grade 3-4 drug-related TEAEs occurred in 31 (26%) participants.
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PMC11224020
Sample groups under different confinement conditions are represented by different forms.
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PMC11361748
B, C, E, F) Violin plots reporting on expression levels for (B, E) KRT6A and (C, F) KRT17 in cells showing high, medium, and low TAR11 scores.
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PMC11049294
The real-time PCR results were calculated according to the following formula: relative expression level = 2 where ∆Ct = Ct (of gene of interest)—Ct (of housekeeping gene) with HPRT as an endogenous control.
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PMC9429973
Results: A total of 220 patients with abnormal karyotypes were detected; 55 (25%) of them showed del(6q) (28 males; R-ISS: 1: 27.5%, 2: 31.1%, 3: 41.4%).
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PMC9429973
Methods: We retrospectively collected pts aged ≥ 18 years (yrs.)
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PMC11629143
Relative enrichment of H3K27ac was 3.2‐fold and 5.0‐fold lower at the CMV promoter of the mAb light and heavy chain genes, respectively, compared to the GAPDH promoter (Figure 2A).
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PMC6114978
Expression of the Hippo kinases was lost at the protein level in 0% (LATS1) to 58% (MST1) of the sarcoma cell lines, indicated by (+).
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PMC7305184
At this experimental point the slope of permeabilization curve is high and the variability between generations is large.
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PMC4270159
Seed cells in plates.
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PMC10723784
If SI <1, this means that the drug is more toxic to non‐cancer cells than cancer cells.
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PMC3019555
In this study, we report a new mechanism of HIF-1α translational regulation that requires the presence of functional microtubules.
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PMC10237474
For Fc-tagged proteins, a 5–10 mL mAb Select Sure column (cat.
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PMC11377827
Deubiquitination as a mechanism to reverse the action of VHL has been observed (Gao et al, 2021; Li et al, 2005; Mennerich et al, 2019; Troilo et al, 2014; Wu et al, 2016), but the relative importance of individual DUBs remains unresolved.
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PMC10761218
The MTT assay findings of the methanolic leaf and stem extracts of W. somnifera indicate a significant degree of cytotoxicity on HepG2 cells, ranging from high to moderate, while demonstrating only weak cytotoxicity on the L929 cell line .
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PMC11224020
For the T cell presentation assay, OVA peptide (Cayla, vac-isq) was added to each condition with the corresponding concentration.
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PMC11777207
Representative flow plots showing KikRed (photoconverted) skin-derived cDC subsets in isotype and αPD-1–treated mice. (
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PMC9429973
A. Ejaz, C. Harris, B. Tseu, A. A. Kirkwood, S. Bhuva, N. Taylor, C. A. Johnson, L. Wing, G. P. Collins University of Oxford; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford; Cancer Research UK & UCL Cancer Trials Centre, University College London, London; Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom Background: Lymphoma is usually diagnosed on biopsy, but clues to a possible diagnosis may be found earlier in the diagnostic pathway when patients undergo CT imaging.
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PMC11747885
Using this criterion, we identified 159 molecules as hits and selected 21 (1–21) of these for further testing based on their biological targets and chemical structure.
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PMC9429973
In addition, synergy was observed when ENTO or LANRA was combined with a Menin inhibitor in MLLr, FLT3-ITD cell lines.
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PMC10577955
This is the first report on the anti-cancer activity of acetoxy-lup-5(6), 20(29)-diene (ALUP) in reducing the proliferation and differentiation of the A549 cell line through inducing apoptosis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC11204465
Organisation of gene clusters of AFs biosynthesis pathway .
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PMC9895440
Cells were then washed twice in FACS buffer and then acquired on an Imagestream MKII imagestream instrument using automated plate handling.
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PMC11001582
b, Representative image of the cortex, enhanced magnification of the motor cortex (area delineated in yellow) and quantification of CTIP2-positive upper motor neuron density in layer V of the motor cortex in WT, (GR)400 and (PR)400 mice at 12 months of age.
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PMC11291490
Following this, the sequence similarity decreases, with hsCD40L and msCD40L exhibiting identity levels of 46.48% and 40.85%, respectively (Supplementary Fig. 1b).
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PMC11782508
The assignments of some of the peaks are indicated in the spectrum.
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PMC11798926
SynDIG1 and SynDIG2 are enriched in the trans-Golgi network.
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PMC9927933
However, it should be noted that other pathways are likely involved, given the observation of partial rescue by DEPTOR knockdown in lung cancer cells.
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PMC11085211
The number of viable cells in the sample was defined starting from the cell concentration (cells/μL) calculated by the flow cytometer instrument.
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PMC9429973
Methods: We set up a functional experimental platform with 73 stimulus-cytokine pairs to comprehensively characterize the immune profile of pediatric patients with BCP-ALL with the two most common genetic subtypes, either carrying the ETV6/RUNX1 (E/R) gene fusion or the high-hyperdiploid (HD) karyotype in comparison with an age-and gender-matched healthy control cohort without BCP-ALL and their healthy parents (in total n = 101 individuals).
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PMC11519583
We surveyed Wnt proteins whose expression in TA muscle was inhibited by Ctx injection but sustained or enhanced by glycerol injection.
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PMC11705862
Normal distribution of data was verified with histogram and Q-Q plot, whereas the standard deviation between the groups was visually inspected with scatter plot.
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PMC11786767
B and C: Distribution of biotin-DHPE and PS.
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PMC9429973
Results: AML can be targeted with an NKG2D CAR since all patients studied expressed at least one NKG2DL (Fig.1).
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PMC11612626
Multiple myeloma cells were incubated with T cells at E:T ratios of 1:1, 2:1, and 3:1 and T-cell–mediated tumor lysis analyzed by gating for CD138, annexin V, and PI cells (Fig. 7B; Supplementary Fig. S5B; Supplementary Table S4).
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PMC11653533
Furthermore, methanol extract of figs of Ficus religiosa has manifested anti-amnesic potency with a noteworthy memory improvement in scopolamine-induced anterograde and retrograde amnesia mice.
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PMC9429973
Statistical analyses were performed using SPSS Version 25 (IBM Corporation, Armonk, NY, USA).
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PMC9429973
Intravenous immunoglobulins (IVIg), platelet transfusion or prednisone will be considered rescue treatment.
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PMC11696576
Data are the mean ± stdev of technical duplicates.
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PMC11225860
Fig. 2Disruption of Alisertib induced polyploidy by Aurkin A. U2932 cells were treated for three or five days with DMSO, Alisertib, Aurkin A, or a combination Alisertib and Aurkin A. Cells were harvested, stained with a propidium iodide solution, and analyzed via flow cytometry (A, B).
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PMC4839679
The loss-of-function gene mutations have been identified for A704 but to the best of our knowledge, the sequencing of the PBRM1 gene in Caki2 has not been previously reported.
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PMC8414691
According to this hypothesis, the cell division defects caused by SRCAP and DOM-A depletion in HeLa and Drosophila S2 cells, respectively, are indirect and their recruitment to the mitotic apparatus only reflects a passive accumulation of disposable factors. (
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PMC8973085
Yellow solid (82%); mp: 268–270 °C (EtOH); IR (KBr, v, cm): 3468 (NH), 3328 (NH), 2221 (CN), 1675 (C=O), 1627 (C=O); H NMR (DMSO-d6): δ 2.34 (s, 3H, CH3), 2.61 (s, 3H, CH3), 3.68 (s, 3H, OCH3), 3.71 (s, 3H, OCH3), 4.17 (s, 2H, CH2), 6.95–7.87 (m, 11H, CH-Ar), 9.50 (bs, 1H, NH), 10.45 (bs, 1H, NH); C NMR (DMSO-d6): δ 20.90, 21.50, 40.10, 56.80, 57.10, 105.20, 112.60, 113.50, 113.90, 115.90, 116.10, 122.50, 123.10, 127.30, 129.20, 129.60, 134.60, 135.10, 136.80, 150.40, 154.30, 155.60, 162.30, 163.10, 165.30, 168.60, 170.20; MS m/z (%): 570 [M] (40).
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PMC11585587
GraphPad Prism 9.0 software was used to draw the cells growth curves after being treated with RA and calculate the maximum median inhibitory concentration (IC50) value.
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PMC9429973
Preliminary data from a Phase Ib study have suggested favorable safety and promising activity of M in combination with lenalidomide (Len), a potent immunomodulatory agent that has shown additive/synergistic activity with an anti-CD20 antibody in R/R indolent lymphoma (Leonard et al. 2019), in patients with R/R FL who have received ≥1 prior therapy (NCT4246086; Morschhauser et al. ASH 2021).
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PMC10745221
Thus, the association between methionine addiction and PRMT function may vary among different types of cancer cells.
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PMC11621493
mPLA2G4D-derived reaction products using an equimolar substrate mixture of 2–18:1 MAG and 2-20:4 MAG (0.5 mM each).
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PMC9100622
As all three tested statins give very similar results on Ewing cell lines, we selected Atorvastatin to assess its impact on cell-cycle progression and on apoptosis in three Ewing cell lines.
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PMC11412721
Statistical analyses by Student’s t-test.
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PMC8557138
The 3D spatial arrangement of organoid is due to its ability to self-organize by cell sorting and in a spatially confined lineage commitment (Takebe et al. 2017).
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PMC10092581
H NMR spectra were recorded at t=0, 24 h, 48 h and 9 days to investigate the stability of the complexes in aqueous solution.
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PMC11345828
The resultant compound was N-alkylated using General Procedure D followed by saponification using General Procedure G to afford the title compound (500 mg, 74% yield).
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PMC11222184
In another study, Hsp90 inhibitors, geldanamycin and 17-allylaminogeldanamycin (17-AAG), induced G2/M arrest along with decreased protein levels of CDC25C and CDC2 in lung cancer cell lines .
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PMC11367939
C–E 20 μm (top) or 2 μm (bottom) Absence of synaptophysin and ATG9A segregation on Rab5 mutant giant endosomes.
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