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PMC10135767
This could be attributed to the longer delay time and peak time in calcium bursting of RPMI 8226 cells mediated by integrin α4β7.
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PMC9429973
Results: Both groups of patients were demographically comparable.
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PMC11792888
p < 0.05 compared to non-cancerous cells from Kruskal-Wallis non-parametric test.
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PMC11363012
We performed both targeted and untargeted scMS analyses for leaf, root, and petal cells and then compared each of these scMS data sets to the corresponding scRNA-seq data from the same tissue.
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PMC11763764
In addition to improving the methods of delivering the SORL1 antibody specifically to cancer cells, we also need to further evaluate the molecular, cellular, and in vivo effects of SORL1 inhibition.
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PMC11730000
In another study, hydroxytyrosol, the primary phenolic compound found in olive oil, effectively prevented the cytotoxicity of DOX generated in cardiomyocytes by regulating the oxidative response and apoptotic processes mediated by the Bcl-2/Bax ratio.
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PMC10040136
Therefore, further studies are necessary to compare the impact of bone marrow MSC and adipose tissue MSC on drug resistance development in GIST patients, and to further authenticate our findings in vivo.
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PMC11459296
Human immune cell infiltration was examined in PB, BM, liver, spleen, and within the s.c.
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PMC11389534
While the majority of research has been conducted on macrophages, , , , it is now evident that IFN‐γ is produced by various lymphocytes, and hundreds of human cell types expressing the signalling machinery may have the ability to respond to IFN‐γ.
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PMC11792090
After incubation, the cells were washed with PBS and analyzed by flow cytometry using a fluorescence-labeled anti-CD70 antibody to identify the test ligand targets.
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PMC9398137
Co-targeting of MCL1 and BCL2 is highly effective in subsets of aggressive B-NHL.
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PMC11750165
Arrowhead indicate NdeI cleavage site (C).
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PMC11297139
Statistical differences in tumor weights were determined by Wilcoxon signed rank test using the Graphpad prism.
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PMC9429973
There is some evidence that ASA in dose 100 mg once daily results in incomplete inhibition of a platelet function over the whole 24-hour interval in most patients with essential thrombocythemia (ET).
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PMC9509578
The results indicated the FGB nanoconjugate proved to be a potent inhibitor as compared to bilirubin and AuNPs alone.
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PMC11541241
Their results together supported the conclusion that the reduced VdTOR activity influenced the mycelial growth and pathogenicity of V. dahliae.
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PMC4443654
A recurring question has been how these many different levels of chromatin structure are related to one another .
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PMC11714165
The peptides (25 µM) were then administered to the BMM cells for 24 h. By staining cells with the tartrate‐resistant acid phosphatase (TRAP) staining kit (Sigma), osteoclast differentiation was assessed.
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PMC11468365
This vector is then concatenated with the cell line feature vectors into a single combined vector.
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PMC10748106
Moreover, we observed that the presence of different functional groups, such as an aldehyde or a carboxylic acid, the hydroxyls in C1 and C8, and the lack of the double bond in C7–C8 influenced the biological activity of the iridoids.
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PMC8427838
Polyclonal rabbit anti-α-tubulin antibody, polyclonal rabbit-anti-acetyl (K40)-tubulin antibody, anti-Myc antibody, and anti-GFP antibody all were purchased from Cell Signaling Technology Inc., (Danvers, MA).
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PMC11521786
In a four-dose induction scheme ( Figure 1A ), immunization with murine ErbB3-ECD (mErbB3) (adjuvated in VSSP/Montanide) induces a specific PAbs response.
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PMC11745355
BxPC3 treated with 5 μM or 15 μM of different compounds for 24 h.
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PMC10204952
The above analyses suggest that S1P can selectively induce apoptosis in TNBC cells at high concentrations (> 1000 nM) and this effect is likely via its intracellular functions.
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PMC11301242
The P value was computed from two-sided Wilcoxon rank-sum test. (
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PMC11301242
Remarkably, even post copy number correction, transcription levels of ecDNA genes were still elevated compared to most non-circularized samples, suggesting that the increased transcription of ecDNA genes is copy number-independent (Fig. 3E).Fig.
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PMC11543853
Images of empty particles were binned to 224 pixels.
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PMC9429973
Aims: We aimed to describe the clinical features, treatment outcomes and genomic characteristics of tMZL.
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PMC11536589
Additionally, we found that PKF-118-310, an antagonist of β-catenin/Tcf4 complex, repressed MGST1 expression.
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PMC9429973
Patients received lymphodepletion with cyclophosphamide and fludarabine, followed 2–7 days later by liso-cel infusion at a target dose of 100 × 10 CAR T cells.
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PMC3813807
The relative expression of miR-373 measured using RT-PCR demonstrated that miR-373 expression levels in the AGS cells were markedly higher than in the GES-1 cells, where the level was almost undetected.
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PMC11463018
19 showed no activity against HDAC4 and 5.
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PMC11661040
K-L) Wound healing assay was performed to evaluate the migratory ability of stable CGREF1-knockdown cells compared to control cells.
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PMC11762280
This study provides further evidence of the diversity of keratinocyte death fates after UVB irradiation and is instructive for the development of therapeutic strategies for UV-related skin diseases.
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PMC11538390
Association testing in the Estonian Biobank cohort data was also performed using REGENIE (v2.2.4), including sex, age and the first 10 PCs as covariates.
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PMC11683240
Therefore, the effect of α1AT on aggregate formation with PT or TcdB was tested by incubating the toxins with α1AT in reaction tubes followed by centrifugation.
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PMC9739791
The stability of the Pt(IV) prodrugs 17–26 in the dark and the rate of reduction was monitored by HPLC.
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PMC8481254
Scale bar: 500 µm.
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PMC11015054
These outcomes propose that METTL5 could potentially serve as a novel marker for evaluating the prognosis of patients with HCC.
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PMC9429973
Methods: This is a Phase II, open-label, single-arm, multicenter trial of PHE885 in pts with r/r MM (NCT05172596).
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PMC9429973
A stable knockdown of ~75 % was obtained at 48 to 120 hours and was confirmed by both qPCR and RNA sequencing at 72 hours post-transfection.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "stable", "knockdown", "of", "~75", "%", "was", "obtained", "at", "48", "to", "120", "hours", "and", "was", "confirmed", "by", "both", "qPCR", "and", "RNA", "sequencing", "at", "72", "hours", "post-transfection", "." ] } ]
PMC9739791
Thus, Pt(IV) prodrug 30 is a photocaged polymer prodrug that could release cytotoxic oxaliplatin via one-photon and two-photon absorption.
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PMC10024132
One such treatment is the adoptive transfer of T cells genetically modified to express CD19-specific chimeric antigen receptor (CAR), and another is blinatumomab, a bispecific antibody (bsAb) that directs T cells to kill CD19 cells .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "such", "treatment", "is", "the", "adoptive", "transfer", "of", "T", "cells", "genetically", "modified", "to", "express", "CD19-specific", "chimeric", "antigen", "receptor", "(", "CAR", ")", ",", "and", "another", "is", "blinatumomab", ",", "a", "bispecific", "antibody", "(", "bsAb", ")", "that", "directs", "T", "cells", "to", "kill", "CD19", "cells", "." ] } ]
PMC11673902
In this review, we systematically summarize six methods for inducing cell deformation in different ways to measure the mechanical properties of single cells.
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PMC11774112
Figure 6(A) Tumor growth curves of mice receiving different therapeutic regimens (n =6, mean ± SD). (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "6(A", ")", "Tumor", "growth", "curves", "of", "mice", "receiving", "different", "therapeutic", "regimens", "(", "n", "=", "6", ",", "mean", "±", "SD", ")", ".", "(" ] } ]
PMC11683240
For the intoxication of cells by PT, it is crucial that PTS1 is taken up into cells and reaches its specific substrate Gαi in the cytosol.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "intoxication", "of", "cells", "by", "PT", ",", "it", "is", "crucial", "that", "PTS1", "is", "taken", "up", "into", "cells", "and", "reaches", "its", "specific", "substrate", "Gαi", "in", "the", "cytosol", "." ] } ]
PMC11653533
Ascorbic acid and gallic acid were used as reference standards for comparison.
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PMC11474209
Changes in cyclin-dependent kinase (CDK) activity frequently underlie tumor-associated cell cycle abnormalities, which cause unpremeditated proliferation and chromosomal instability.
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PMC11607764
Additionally, PTBP1’s critical involvement in RNA metabolism and the p53 signaling pathway, along with its extensive interactions with cancer-related genes and proteins, offers new perspectives for understanding cancer prognosis and addressing treatment resistance, thus filling some gaps left by current biomarkers.
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PMC6642070
Furthermore, we identified the increased expression of muscle specific glycolytic enzyme β-enolase through promoting the degradation of basal p53 is the underlying mechanism, which was dependent on the inhibitory activity on HMG-CoA reductase of statins.
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PMC11354239
, as per the manufacturer’s recommendations.
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PMC11752740
These findings are consistent with previous research demonstrating that treatments involving CFZ, either alone or in combination with agents like curcumin, resulted in decreased nuclear accumulation of NF-κB. This reduction, in turn, diminished the transcription of survival genes dependent on NF-κB .
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PMC11634027
Here, we assess signaling downstream of Dachsous through analysis of its intracellular domain.
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PMC11521786
Also, HER3 activation has been shown to predict resistance to antitumor therapies, including chemotherapy, HER1-targeting inhibitors, estrogen antagonists, or radiation (9, 11–13).
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PMC10604092
In accordance with the manufacturers’ instructions, we lifted the rats by their tails to allow their front paws to grab a measuring bar.
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PMC10968586
Using MCF-7 cell line, which is devoid of HER-2 overexpression , 200 μg/mL (≈370 μM) OLE for 48 h showed a specific cytotoxic effect on MCF-7 cell line, leaving the non-cancerous cell line MCF-10A unharmed.
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PMC11409031
In Fig. 4E, each gene's chromosomal positions are presented, and the model's median risk score divides the TCGA-OV cohort (training set) and the GEO cohort (validation set) into high-risk and low-risk groups.
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PMC11694346
It also shows good selectivity over other analytes and linear relationship in concentration titration tests, along with lower cytotoxicity and stability in physiological pH conditions.
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PMC9848491
The network included 198 pairs lncRNA-mRNA co-expression ( Figure 2D , |R2 | > 0.3 and p<0.001).
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PMC5363531
For Western blot analysis the following antibodies were used: cSrc (32G6), pSrc, (Tyr419) (D49G4); phosphoinositide 3-kinase (PI3K) p110α subunit (C73F8), PI3K p110β subunit (C33D4) and phospho-ribosomal protein S6K (p-p70S6K [Thr389]) from Cell Signaling Technology (Danvers, MA, USA); Beta-actin (C4); Vinculin (N-19), pAkt1/2/3 (11E6) and Akt (all from Santa Cruz Biotechnology, Dallas, TX, USA); Thymidylate Synthase (TS) (EPR4545), mammalian target of rapamycin (mTOR (ab2732)), from AbCam (Cambridge, UK).
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PMC4443654
The EGR1 transcription factor plays critical roles in cellular differentiation and shows markedly higher variable importance in the H1 hESC model.
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PMC11306019
Finally, we generated the combination index (CI) plot using the Chou-Talalay method (Chou et al., 1994).
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PMC8382973
No cytotoxicity (level 0) was defined as cell viability ≥ 100%, minimum cytotoxicity (level 1) was defined as 80% ≤ cell viability <100%, mild cytotoxicity (level 2) was defined as 50% ≤ cell viability < 80%, moderate cytotoxicity (level 3) was defined as 30% ≤ cell viability < 50%, and severe cytotoxicity (level 4) was defined as cell viability < 30%.
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PMC8735881
TZM-bl cells were then transduced with the recombinant lentiviruses and sorted by fluorescence-activated cell sorter (FACS) to obtain a cell population in which close to 100% of the cells expressed GPI-anchored scFvs.
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PMC11748335
MACS2 was utilized to subtract input and identify narrow peaks with “-q 0.01 –keep-dup 1” options .
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PMC11637820
The results indicated a dose-dependent decrease in pH (Fig. 1C).
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PMC10743717
No one should have the right to cover errors in their publications without corrigenda to prevent their readers from being misled.
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PMC11683130
For example, losartan act as an angiotensin receptor (AT1R) antagonist, attenuates imiquimod-induced psoriasis-like inflammation (171).
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PMC6684588
The importance of this microenvironment is illustrated by its ability to restore functionality to satellite cells removed from dystrophic muscle.
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PMC9429973
Aims: We aimed to evaluate the efficacy of INO in clearing MRD in patients (pts) with persistent or recurrent MRD positivity after treatment with conventional chemotherapy.
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PMC11637276
After 48 h, spheroids were embedded in 40 μl of 3 mg/ml rat tail collagen I (Corning) and 3 mg/ml Matrigel (Corning).
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PMC8584319
HepG2 cells treated with 2 μM AZD8055 for 2–24 h were pulse-labeled with puromycin.
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PMC6835428
This was true for both the FR-targeted and -non-targeted particles, and was probably the consequence of the fast extravasation with predominant accumulation in the liver.
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PMC2118063
Data for IRF8 B cells are normalized to levels in +/+ B cells and indicate the means ± SEM for four mice. (
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PMC11204465
AFGM2a (92) was hydration of the terminal furan ring of AFM1 in dilute acid to yield a hemiketal in vitro in liver homogenates .
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PMC8010066
Briefly, the bacterial strains were cultured on a TSB medium overnight and then centrifuged at 10000 g for five minutes.
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PMC9429973
Ann-Arbor staging included 56 patients (78.8%) with stage III-IV, and 19 patients (26.8%) with B symptoms.
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PMC10452486
The Face-2 clustering correlated with the presence of the HC-10 epitope of Face-2 at the cell surface.
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PMC9429973
The metabolic activity decrease was even more relevant in the combination scheme of small doses of DNMTis plus HDACis (0.1µM AZA+0.1µM SAHA, 0.1µM AZA+0.1nM PAN, 0.5µM DAC+0.1µM SAHA and 0.5µM DAC+0.1nM PAN), reaching a 75% decrease in metabolic activity.
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PMC11678841
After incubation, the cells were treated with 2 mL of complete medium containing α-TOH (25 and 50 µM) or GA (10 and 25 µM) for 48 h under the same conditions.
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PMC11588008
The umbilical cord was cut longitudinally along the lumen of the umbilical vein, the inner membrane of the umbilical vein was peeled off, and the tissue was cut to a block smaller than 1 mm × 1 mm × 1 mm.
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PMC11589157
K-mer distribution analysis (K = 21) using GenomeScope v2.0 revealed an estimated heterozygosity rate of 0.39%, comparable to that of Hylobates moloch (0.38%–0.39%) and falling within the range of the Hylobatidae family (0.19%–0.41%).
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PMC9429973
Transfer to the ICU was required in 78 (60%) patients in the total group and in 41 patients (52.5%) among those older than 60 years.
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PMC11488203
The vesicles were analyzed by transmission electron microscopy as described previously (suppl.
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PMC11502443
Data were normalized to the maximal response produced by GIP(1-42) for each signaling pathway and expressed as a percentage.
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PMC9684669
Ovarian cancer is one of the most lethal gynecological malignancies.
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PMC11629461
Excessive ROS production by NOX5 is associated with coronary atherosclerosis, acute myocardial infarction, fetal ventricular septal defect, or cancer.
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PMC11708541
Antibiotics are the “magical shots” that fight bacteria, their discovery is regarded as a medical marvel.
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PMC9429973
By contrast with these noncoding transcripts, the levels of corresponding PCGs (namely KDM1A/1B/4B) were not altered between AZA responders and nonresponders, suggesting that the deregulated ncRNAs play specific roles independent of their host genes.
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PMC11591038
Comparing the death tolls from 2000 to 2019 among various diseases, death caused by human immunodeficiency virus, cardiac diseases, and cerebrovascular disorders declined while those from AD increased by more than 145% .
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PMC9429973
Long-term duration of maintenance which was defined as over 24 months translated into significant better PFS in all groups (T-MT 57.2m vs 12.1m, L-MT 54.3m vs 19.2m, B-MT 37.3m vs 16.7m, p＜0.01), as well as better OS.
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PMC10758402
Finally, we demonstrate that DMF in combination with oHSV-1 can improve therapeutic outcomes in aggressive syngeneic murine cancer models.
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PMC11756514
Recombinant human soluble Langerin ECD (residues 65-328 in Uniprot Q9UJ71) was expressed from the pET30a expression vector carrying kanamycin (KAN) resistance (GenScript, NJ).
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PMC9429973
20% of the biopsies showed transformation areas to DLBCL.
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PMC11240052
In the present study, we characterized circRNA transcripts using RNA sequencing (RNA-seq) analyses of ribosomal RNA-depleted total RNA from nine pairs of ovarian cancer and adjacent non-cancerous tissue samples.
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PMC11462673
Consistent with these findings, western blot analysis uncovered a reduction in the expression of Bcl2, along with the presence of cleaved bands of PARP, cleaved caspase-3 and caspase-8 five days after virus transfection (Fig. 2H).
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PMC6034753
The best-characterised binding motif for apoptin is the SH3 domain that is present in Bcr-Abl and p85 subunit of PI3-Kinase , outside of this domain an apoptin interacting motif has not been described.
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PMC9817179
All analyses were done on normalized maximum z-projection images except for when calculating punctate percentage.
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PMC11612626
A, Schematic representation of the cell-based HTS.
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PMC11419566
The anticancer action of PA was achieved through a variety of mechanisms.
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