OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11562028	All the mice were randomly divided into 4 groups (n = 5): control group, model group, 5-FU group, and Re-CDs group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "the", "mice", "were", "randomly", "divided", "into", "4", "groups", "(", "n", "=", "5", "):", "control", "group", ",", "model", "group", ",", "5-FU", "group", ",", "and", "Re-CDs", "group", "." ] } ]
PMC11337594	A375 and CASP3-KO cells were treated with TER (2.0 µg/ml) or DMSO for 24 h, and then labeled with Annexin V-FITC/PI for observation under a fluorescence microscope. (	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A375", "and", "CASP3-KO", "cells", "were", "treated", "with", "TER", "(", "2.0", "µg/ml", ")", "or", "DMSO", "for", "24", "h", ",", "and", "then", "labeled", "with", "Annexin", "V-FITC/PI", "for", "observation", "under", "a", "fluorescence", "microscope", ".", "(" ] } ]
PMC8526701	Bromodomain proteins can further be subdivided into two families, the BET and non-BET families, on the basis of their structural parameters .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bromodomain", "proteins", "can", "further", "be", "subdivided", "into", "two", "families", ",", "the", "BET", "and", "non-BET", "families", ",", "on", "the", "basis", "of", "their", "structural", "parameters", "." ] } ]
PMC11640247	These observations underscore the complexity of RAC3 signaling pathways and suggest that similar migration phenotypes may result from distinct molecular mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "observations", "underscore", "the", "complexity", "of", "RAC3", "signaling", "pathways", "and", "suggest", "that", "similar", "migration", "phenotypes", "may", "result", "from", "distinct", "molecular", "mechanisms", "." ] } ]
PMC11802929	Note that two of the expressed SCT constructs were not included for 10X experiment due to low sample volume.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Note", "that", "two", "of", "the", "expressed", "SCT", "constructs", "were", "not", "included", "for", "10X", "experiment", "due", "to", "low", "sample", "volume", "." ] } ]
PMC9429973	NLR was no longer significant in multivariate analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NLR", "was", "no", "longer", "significant", "in", "multivariate", "analysis", "." ] } ]
PMC5839394	After 24 h cells were incubated for 24 h with the IC50 concentration of the AgNPs-EPS, and observed for morphological changes assessment under a phase contrast inverted microscope (Carl Zeiss) at 400X magnification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "24", "h", "cells", "were", "incubated", "for", "24", "h", "with", "the", "IC50", "concentration", "of", "the", "AgNPs-EPS", ",", "and", "observed", "for", "morphological", "changes", "assessment", "under", "a", "phase", "contrast", "inverted", "microscope", "(", "Carl", "Zeiss", ")", "at", "400X", "magnification", "." ] } ]
PMC11269933	In vivo phosphorylation assay of different CgERK1/2 mutants on CgPK Ser11 site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "vivo", "phosphorylation", "assay", "of", "different", "CgERK1/2", "mutants", "on", "CgPK", "Ser11", "site", "." ] } ]
PMC11721277	NMR spectra were obtained on a Bruker DPX300 spectrometer (Bruker Corporation, Billerica, MA, USA) using CDCl3 and DMSO-d6 as solvents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NMR", "spectra", "were", "obtained", "on", "a", "Bruker", "DPX300", "spectrometer", "(", "Bruker", "Corporation", ",", "Billerica", ",", "MA", ",", "USA", ")", "using", "CDCl3", "and", "DMSO-d6", "as", "solvents", "." ] } ]
PMC9429973	A web-based online tool based on this algorithm rapidly identifies the bleeding risk profile of ITP patients to support clinical decision-making and reduce the occurrence of adverse outcomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "web-based", "online", "tool", "based", "on", "this", "algorithm", "rapidly", "identifies", "the", "bleeding", "risk", "profile", "of", "ITP", "patients", "to", "support", "clinical", "decision-making", "and", "reduce", "the", "occurrence", "of", "adverse", "outcomes", "." ] } ]
PMC11352311	We first analyzed the 47 esculin targets identified from SwissTargetPrediction and the 2085 RCC targets obtained from the GeneCards database using Venn diagrams, identifying 22 intersecting genes (Supplementary Table S1) (Figure 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "first", "analyzed", "the", "47", "esculin", "targets", "identified", "from", "SwissTargetPrediction", "and", "the", "2085", "RCC", "targets", "obtained", "from", "the", "GeneCards", "database", "using", "Venn", "diagrams", ",", "identifying", "22", "intersecting", "genes", "(", "Supplementary", "Table", "S1", ")", "(", "Figure", "1B", ")", "." ] } ]
PMC11594641	Previously, Rab27A was found to control the secretion of sEVs in mouse B16-F10 and human SkMel28 melanoma cells and to promote primary tumor growth in mice .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previously", ",", "Rab27A", "was", "found", "to", "control", "the", "secretion", "of", "sEVs", "in", "mouse", "B16-F10", "and", "human", "SkMel28", "melanoma", "cells", "and", "to", "promote", "primary", "tumor", "growth", "in", "mice", "." ] } ]
PMC11049294	Incubation of GLA KO Jurkat cells with 2.83 nmol/mL Fl-Gb3 showed the same pattern of substrate accumulation as the DGJ-specific AGAL inhibitor-treated WT Jurkat cells.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Incubation", "of", "GLA", "KO", "Jurkat", "cells", "with", "2.83", "nmol/mL", "Fl-Gb3", "showed", "the", "same", "pattern", "of", "substrate", "accumulation", "as", "the", "DGJ-specific", "AGAL", "inhibitor-treated", "WT", "Jurkat", "cells", "." ] } ]
PMC11612794	The cells images were acquired by the confocal microscopy with spinning-disc.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "images", "were", "acquired", "by", "the", "confocal", "microscopy", "with", "spinning-disc", "." ] } ]
PMC9429973	Moreover, 6 out of 11 (55%) mutations identified in the PPCs were observed in cfDNA and BM (Figure 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "6", "out", "of", "11", "(", "55", "%", ")", "mutations", "identified", "in", "the", "PPCs", "were", "observed", "in", "cfDNA", "and", "BM", "(", "Figure", "1A", ")", "." ] } ]
PMC8345486	The results of two viability tests (NR and ATP measurement) are consistent: compound 23 exhibited high cytotoxicity independent of platinum resistance to adherent cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "of", "two", "viability", "tests", "(", "NR", "and", "ATP", "measurement", ")", "are", "consistent", ":", "compound", "23", "exhibited", "high", "cytotoxicity", "independent", "of", "platinum", "resistance", "to", "adherent", "cells", "." ] } ]
PMC11224206	Hansen , Mietkiewska et al. and Khan et al. have provided excellent accounts of such research and the prospects of it leading to new strategies to mitigate the effects of overheating.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hansen", ",", "Mietkiewska", "et", "al.", "and", "Khan", "et", "al.", "have", "provided", "excellent", "accounts", "of", "such", "research", "and", "the", "prospects", "of", "it", "leading", "to", "new", "strategies", "to", "mitigate", "the", "effects", "of", "overheating", "." ] } ]
PMC11122631	For the medicinal chemistry of the compounds, we evaluated four indicators, including Pan Assay Interference Structures (PAINS), Brenk, lead likeness, and the synthetic accessibility score (Table S20).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "the", "medicinal", "chemistry", "of", "the", "compounds", ",", "we", "evaluated", "four", "indicators", ",", "including", "Pan", "Assay", "Interference", "Structures", "(", "PAINS", ")", ",", "Brenk", ",", "lead", "likeness", ",", "and", "the", "synthetic", "accessibility", "score", "(", "Table", "S20", ")", "." ] } ]
PMC10968586	In fact, in vivo, 50 mg/kg, 100 mg/kg, and 200 mg/kg OLE showed a dose-dependent antioxidant activity, accounting for amelioration of cisplatin-induced pancreatic, liver, lung, and stomach damage in Spraque–Dawley rats .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "fact", ",", "in", "vivo", ",", "50", "mg/kg", ",", "100", "mg/kg", ",", "and", "200", "mg/kg", "OLE", "showed", "a", "dose-dependent", "antioxidant", "activity", ",", "accounting", "for", "amelioration", "of", "cisplatin-induced", "pancreatic", ",", "liver", ",", "lung", ",", "and", "stomach", "damage", "in", "Spraque", "–", "Dawley", "rats", "." ] } ]
PMC10073922	No significant difference was observed between the viability of control and mock groups (p=0.243).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "significant", "difference", "was", "observed", "between", "the", "viability", "of", "control", "and", "mock", "groups", "(", "p=0.243", ")", "." ] } ]
PMC7229095	This practice will also decrease both time and effort, eliminating the need to adapt cells in new media and optimize the production media process.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "practice", "will", "also", "decrease", "both", "time", "and", "effort", ",", "eliminating", "the", "need", "to", "adapt", "cells", "in", "new", "media", "and", "optimize", "the", "production", "media", "process", "." ] } ]
PMC9429973	Cases meeting ≥3 criteria within a 10-day period during the first 12 months after alloHCT were considered potential TA-TMA and were further evaluated by 2 clinicians from each transplant center.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cases", "meeting", "≥3", "criteria", "within", "a", "10-day", "period", "during", "the", "first", "12", "months", "after", "alloHCT", "were", "considered", "potential", "TA-TMA", "and", "were", "further", "evaluated", "by", "2", "clinicians", "from", "each", "transplant", "center", "." ] } ]
PMC11033180	In addition, mice invalidated for Sema5A exhibit ASD-like behaviors and several brain abnormalities including defects in axonal elongation and synaptic activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "mice", "invalidated", "for", "Sema5A", "exhibit", "ASD-like", "behaviors", "and", "several", "brain", "abnormalities", "including", "defects", "in", "axonal", "elongation", "and", "synaptic", "activity", "." ] } ]
PMC11585565	In silico functional prediction of p.(Gly492Cys), p.(Gly492Asp), and p.(Thr495Ile) variant in CNNM4 protein. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "silico", "functional", "prediction", "of", "p.(Gly492Cys", ")", ",", "p.(Gly492Asp", ")", ",", "and", "p.(Thr495Ile", ")", "variant", "in", "CNNM4", "protein", ".", "(" ] } ]
PMC9429973	Grade 3 or higher TEAEs were reported in 30 pts (53%), with neutropenia and increased ALT in 5 pts (9%) being the most frequent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Grade", "3", "or", "higher", "TEAEs", "were", "reported", "in", "30", "pts", "(", "53", "%", ")", ",", "with", "neutropenia", "and", "increased", "ALT", "in", "5", "pts", "(", "9", "%", ")", "being", "the", "most", "frequent", "." ] } ]
PMC11684821	It is not yet known whether other allelic variants of MR1 affect protein function or expression levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "not", "yet", "known", "whether", "other", "allelic", "variants", "of", "MR1", "affect", "protein", "function", "or", "expression", "levels", "." ] } ]
PMC11352746	Cell viability assays have a wide choice of methods, including the MTT assay, Cell Titer-Glo assay, and Ethidium homodimer assay .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "viability", "assays", "have", "a", "wide", "choice", "of", "methods", ",", "including", "the", "MTT", "assay", ",", "Cell", "Titer-Glo", "assay", ",", "and", "Ethidium", "homodimer", "assay", "." ] } ]
PMC9583612	Finally, emissions across multiple rounds on the same day were averaged to estimate a daily average emission rate for each facility (see Section S4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "emissions", "across", "multiple", "rounds", "on", "the", "same", "day", "were", "averaged", "to", "estimate", "a", "daily", "average", "emission", "rate", "for", "each", "facility", "(", "see", "Section", "S4", ")", "." ] } ]
PMC8170755	Nevertheless, modulation of multiple growth factors and matrix metalloproteinases (MMPs) may be involved (6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nevertheless", ",", "modulation", "of", "multiple", "growth", "factors", "and", "matrix", "metalloproteinases", "(", "MMPs", ")", "may", "be", "involved", "(", "6", ")", "." ] } ]
PMC7305184	Variation between generations is present at the slope of survival curve (Fig. 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Variation", "between", "generations", "is", "present", "at", "the", "slope", "of", "survival", "curve", "(", "Fig.", "3", ")", "." ] } ]
PMC11049548	At the level of the endo-metabolome, there are several features that cause HGSOC_T and HGSOC_A cells to occupy a characteristic position in the “metabolic space”, which is intermediate between those of A2780 and A2780cis cells (see PCA score plot in Figure 3A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "the", "level", "of", "the", "endo-metabolome", ",", "there", "are", "several", "features", "that", "cause", "HGSOC_T", "and", "HGSOC_A", "cells", "to", "occupy", "a", "characteristic", "position", "in", "the", "“", "metabolic", "space", "”", ",", "which", "is", "intermediate", "between", "those", "of", "A2780", "and", "A2780cis", "cells", "(", "see", "PCA", "score", "plot", "in", "Figure", "3A", ")", "." ] } ]
PMC11045125	These results confirm that decreased Src and STAT3 expression in ΔEBNA2 + Myc tumors is an important mechanism by which Myc turns off LMP1 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "confirm", "that", "decreased", "Src", "and", "STAT3", "expression", "in", "ΔEBNA2", "+", "Myc", "tumors", "is", "an", "important", "mechanism", "by", "which", "Myc", "turns", "off", "LMP1", "expression", "." ] } ]
PMC11727638	Another method of collecting cells that behave similarly to Cell Dome cultured cells in a short period involves miniaturizing the Cell Dome by mechanizing its preparation process and changing the size of the water-repellent ring pattern printed on the glass plates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "method", "of", "collecting", "cells", "that", "behave", "similarly", "to", "Cell", "Dome", "cultured", "cells", "in", "a", "short", "period", "involves", "miniaturizing", "the", "Cell", "Dome", "by", "mechanizing", "its", "preparation", "process", "and", "changing", "the", "size", "of", "the", "water-repellent", "ring", "pattern", "printed", "on", "the", "glass", "plates", "." ] } ]
PMC11612794	Immunoprecipitated samples were subjected to immunoblot analyses using anti-CENP-T, anti-FLAG, and anti-Dsn1 antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunoprecipitated", "samples", "were", "subjected", "to", "immunoblot", "analyses", "using", "anti-CENP-T", ",", "anti-FLAG", ",", "and", "anti-Dsn1", "antibodies", "." ] } ]
PMC11804588	This tool substantially enhances our ability to dissect gene regulatory networks in diverse cell types of multicellular organisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "tool", "substantially", "enhances", "our", "ability", "to", "dissect", "gene", "regulatory", "networks", "in", "diverse", "cell", "types", "of", "multicellular", "organisms", "." ] } ]
PMC10203589	The proportion of S-phase number of cells increased significantly with the stimulation of FGF18, and the angiogenic activity of SW480 cells was increased.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "The", "proportion", "of", "S-phase", "number", "of", "cells", "increased", "significantly", "with", "the", "stimulation", "of", "FGF18", ",", "and", "the", "angiogenic", "activity", "of", "SW480", "cells", "was", "increased", "." ] } ]
PMC9812014	NDV causes infections in poultry farming birds, and it is a persistent threat to the poultry industry all over the world .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NDV", "causes", "infections", "in", "poultry", "farming", "birds", ",", "and", "it", "is", "a", "persistent", "threat", "to", "the", "poultry", "industry", "all", "over", "the", "world", "." ] } ]
PMC10999934	The prognostic value of shared genes for high-grade serous ovarian cancer was assessed with KM plotter (http://kmplot.com/analysis).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "prognostic", "value", "of", "shared", "genes", "for", "high-grade", "serous", "ovarian", "cancer", "was", "assessed", "with", "KM", "plotter", "(", "http://kmplot.com/analysis", ")", "." ] } ]
PMC11746948	Collectively, these results establish APT2 as the regulatory enzyme of GPX4 depalmitoylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Collectively", ",", "these", "results", "establish", "APT2", "as", "the", "regulatory", "enzyme", "of", "GPX4", "depalmitoylation", "." ] } ]
PMC9812014	1Structures of some antiviral alkaloids Structures of some antiviral alkaloids In this review, the antiviral role of some alkaloids of different origins against a variety of viruses is presented.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1Structures", "of", "some", "antiviral", "alkaloids", "Structures", "of", "some", "antiviral", "alkaloids", "In", "this", "review", ",", "the", "antiviral", "role", "of", "some", "alkaloids", "of", "different", "origins", "against", "a", "variety", "of", "viruses", "is", "presented", "." ] } ]
PMC11496491	In terms of molecular function, differential genes are most significantly enriched in terms of protein binding, ion binding, and protein domain specific binding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "terms", "of", "molecular", "function", ",", "differential", "genes", "are", "most", "significantly", "enriched", "in", "terms", "of", "protein", "binding", ",", "ion", "binding", ",", "and", "protein", "domain", "specific", "binding", "." ] } ]
PMC11743414	Rabbit anti-FHL1 (1:1000; Proteintech, Wuhan, China) and rabbit anti-β-tubulin (1:5000; Abcam, Cambridge, UK) were incubated overnight at 4 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rabbit", "anti-FHL1", "(", "1:1000", ";", "Proteintech", ",", "Wuhan", ",", "China", ")", "and", "rabbit", "anti-β-tubulin", "(", "1:5000", ";", "Abcam", ",", "Cambridge", ",", "UK", ")", "were", "incubated", "overnight", "at", "4", "°", "C", "." ] } ]
PMC11674891	In datasets GSE50081, GSE19188, and GSE14814, higher GRPR expression was associated with poorer overall survival rates (p = 2.8 × 10 for GSE50081 (N = 181); p = 2.7 × 10 for GSE19188 (n = 82); p = 9.9 × 10 for GSE14814 (n = 89), log-rank test).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "datasets", "GSE50081", ",", "GSE19188", ",", "and", "GSE14814", ",", "higher", "GRPR", "expression", "was", "associated", "with", "poorer", "overall", "survival", "rates", "(", "p", "=", "2.8", "×", "10", "for", "GSE50081", "(", "N", "=", "181", ")", ";", "p", "=", "2.7", "×", "10", "for", "GSE19188", "(", "n", "=", "82", ")", ";", "p", "=", "9.9", "×", "10", "for", "GSE14814", "(", "n", "=", "89", ")", ",", "log-rank", "test", ")", "." ] } ]
PMC11792090	In the Jurkat reporter cells, a luciferase reporter gene was placed under the control of a nuclear factor of activated T cells (NFAT)-responsive promoter.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "Jurkat", "reporter", "cells", ",", "a", "luciferase", "reporter", "gene", "was", "placed", "under", "the", "control", "of", "a", "nuclear", "factor", "of", "activated", "T", "cells", "(NFAT)-responsive", "promoter", "." ] } ]
PMC11173119	We further differentiated these cells into macrophage-like cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "further", "differentiated", "these", "cells", "into", "macrophage-like", "cells", "." ] } ]
PMC6312945	HBV infection is the main cause of liver cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HBV", "infection", "is", "the", "main", "cause", "of", "liver", "cancer", "." ] } ]
PMC9429973	61/201 pts were selected in the MM treatment (tto) protocols.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "61/201", "pts", "were", "selected", "in", "the", "MM", "treatment", "(", "tto", ")", "protocols", "." ] } ]
PMC10849234	HL-60 (A-D) or PLB-985 (E-H) cells were differentiated into Neutrophil-like cells (NLCs) with DMSO, in addition to either G-CSF or Nutridoma and then left unstimulated (unstim), or stimulated with cytochalasin B and fMLP (fMLP).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HL-60", "(", "A-D", ")", "or", "PLB-985", "(", "E-H", ")", "cells", "were", "differentiated", "into", "Neutrophil-like", "cells", "(", "NLCs", ")", "with", "DMSO", ",", "in", "addition", "to", "either", "G-CSF", "or", "Nutridoma", "and", "then", "left", "unstimulated", "(", "unstim", ")", ",", "or", "stimulated", "with", "cytochalasin", "B", "and", "fMLP", "(", "fMLP", ")", "." ] } ]
PMC7022782	The increase in ICG concentration led to a growth in the peak fluorescence intensity up to a maximum value of dye amount of 2.5 µg/mL. This was followed by a decrease in the peak fluorescence intensity when the dye concentration is increased.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "increase", "in", "ICG", "concentration", "led", "to", "a", "growth", "in", "the", "peak", "fluorescence", "intensity", "up", "to", "a", "maximum", "value", "of", "dye", "amount", "of", "2.5", "µg/mL.", "This", "was", "followed", "by", "a", "decrease", "in", "the", "peak", "fluorescence", "intensity", "when", "the", "dye", "concentration", "is", "increased", "." ] } ]
PMC11188874	Effect of HDAC6 KO on proteasome activity and antigen presentation A, SDS-PAGE of lysates from HDAC6 KO in MMCLs RPMI-8226, U266, and ARH-77.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O" ], "tokens": [ "Effect", "of", "HDAC6", "KO", "on", "proteasome", "activity", "and", "antigen", "presentation", "A", ",", "SDS-PAGE", "of", "lysates", "from", "HDAC6", "KO", "in", "MMCLs", "RPMI-8226", ",", "U266", ",", "and", "ARH-77", "." ] } ]
PMC11705862	The following day the sections were incubated in Ig Impress reagent kit secondary anti-rabbit antibody (Vector Laboratories #MP-7401) at RT for 2 h, and then developed for 2 min in 0.25 mg/ mL diaminobenzidine and 0.012% H2O2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "following", "day", "the", "sections", "were", "incubated", "in", "Ig", "Impress", "reagent", "kit", "secondary", "anti-rabbit", "antibody", "(", "Vector", "Laboratories", "#", "MP-7401", ")", "at", "RT", "for", "2", "h", ",", "and", "then", "developed", "for", "2", "min", "in", "0.25", "mg/", "mL", "diaminobenzidine", "and", "0.012", "%", "H2O2", "." ] } ]
PMC11761919	The values represent mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "values", "represent", "mean", "±", "SD", "." ] } ]
PMC11724582	Additionally, CAFs enhanced the survival of almonertinib-treated NSCLC cells, whereas normal fibroblasts (NFs) exerted the opposite effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "CAFs", "enhanced", "the", "survival", "of", "almonertinib-treated", "NSCLC", "cells", ",", "whereas", "normal", "fibroblasts", "(", "NFs", ")", "exerted", "the", "opposite", "effect", "." ] } ]
PMC10965680	These initiatives include the establishment of conservation areas, conservation farms, and gene banks dedicated to preserving genetic resources of special breeds to safeguard indigenous animal populations for the benefit of future generations (Wei et al., 2014).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "initiatives", "include", "the", "establishment", "of", "conservation", "areas", ",", "conservation", "farms", ",", "and", "gene", "banks", "dedicated", "to", "preserving", "genetic", "resources", "of", "special", "breeds", "to", "safeguard", "indigenous", "animal", "populations", "for", "the", "benefit", "of", "future", "generations", "(", "Wei", "et", "al.", ",", "2014", ")", "." ] } ]
PMC10243817	An ALI culture of HNECs were obtained from controls (5, 56).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "An", "ALI", "culture", "of", "HNECs", "were", "obtained", "from", "controls", "(", "5", ",", "56", ")", "." ] } ]
PMC11656048	According to the protocol, the cells were seeded in confocal dishes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "According", "to", "the", "protocol", ",", "the", "cells", "were", "seeded", "in", "confocal", "dishes", "." ] } ]
PMC11013014	2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)-N-(1-methyl-1H-indol-5-yl)acetamide (4).	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)-N-(1-methyl-1H-indol-5-yl)acetamide", "(", "4", ")", "." ] } ]
PMC11470381	Avoid using confluent cells for transfection, as this can lead to decreased viability and transfection efficiencies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Avoid", "using", "confluent", "cells", "for", "transfection", ",", "as", "this", "can", "lead", "to", "decreased", "viability", "and", "transfection", "efficiencies", "." ] } ]
PMC9429973	Firstly, lymphomas are characterized by pronounced heterogeneity, with distinctive features depending on the biology of lymphoma subtype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Firstly", ",", "lymphomas", "are", "characterized", "by", "pronounced", "heterogeneity", ",", "with", "distinctive", "features", "depending", "on", "the", "biology", "of", "lymphoma", "subtype", "." ] } ]
PMC9429973	Furthermore, our analysis revealed segregation of patients by HOXA13 or ZFP36L2 rearrangements and NUP98/NUP214 fusions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "our", "analysis", "revealed", "segregation", "of", "patients", "by", "HOXA13", "or", "ZFP36L2", "rearrangements", "and", "NUP98/NUP214", "fusions", "." ] } ]
PMC9429973	For example, a 50-year-old male diagnosed with HCL in 1990, on average, has a LEL of 3.8 years (95% confidence interval [CI]: 2.1-5.5), whereas a male with a HCL diagnosis in 2019, on average, has a LEL of 1.0 years (95% CI, 0.3-1.7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", "a", "50-year-old", "male", "diagnosed", "with", "HCL", "in", "1990", ",", "on", "average", ",", "has", "a", "LEL", "of", "3.8", "years", "(", "95", "%", "confidence", "interval", "[", "CI", "]", ":", "2.1", "-", "5.5", ")", ",", "whereas", "a", "male", "with", "a", "HCL", "diagnosis", "in", "2019", ",", "on", "average", ",", "has", "a", "LEL", "of", "1.0", "years", "(", "95", "%", "CI", ",", "0.3", "-", "1.7", ")", "." ] } ]
PMC8358006	Metagenes are centered on the H3K27me3 region (7.6 kb for typical peaks and 75.4 kb for grand H3K27me3 domains), with 3 kb surrounding each peak region.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Metagenes", "are", "centered", "on", "the", "H3K27me3", "region", "(", "7.6", "kb", "for", "typical", "peaks", "and", "75.4", "kb", "for", "grand", "H3K27me3", "domains", ")", ",", "with", "3", "kb", "surrounding", "each", "peak", "region", "." ] } ]
PMC11748335	On the right, a box plot represents the percentage for intergenic and promoter-TSS elements among peaks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "right", ",", "a", "box", "plot", "represents", "the", "percentage", "for", "intergenic", "and", "promoter-TSS", "elements", "among", "peaks", "." ] } ]
PMC5261804	Specifically, we define the essentiality of node i (in the dual graph) at tth step by .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specifically", ",", "we", "define", "the", "essentiality", "of", "node", "i", "(", "in", "the", "dual", "graph", ")", "at", "tth", "step", "by", "." ] } ]
PMC9429973	For assessment of adverse events (AEs) NCI CTCAE v. 4.0 was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "assessment", "of", "adverse", "events", "(", "AEs", ")", "NCI", "CTCAE", "v.", "4.0", "was", "used", "." ] } ]
PMC11723947	As expected, the frequency of PD-1 and LAG-3-expressing cells and the average expression of these immune checkpoints were higher in HP1γ-deficient cells than in control cells (Fig. 6h, k).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "expected", ",", "the", "frequency", "of", "PD-1", "and", "LAG-3-expressing", "cells", "and", "the", "average", "expression", "of", "these", "immune", "checkpoints", "were", "higher", "in", "HP1γ-deficient", "cells", "than", "in", "control", "cells", "(", "Fig.", "6h", ",", "k", ")", "." ] } ]
PMC9024365	Thus, it is tempting to speculate that SD4 captures AMPARs at the plasma membrane for clustering via transport through an endocytic compartment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "it", "is", "tempting", "to", "speculate", "that", "SD4", "captures", "AMPARs", "at", "the", "plasma", "membrane", "for", "clustering", "via", "transport", "through", "an", "endocytic", "compartment", "." ] } ]
PMC9878562	BLT1R is well known to mediate chemotaxis of leukocytes in response to LTB4 (50), while the ubiquitously expressed BLT2R is more involved in regulating inflammatory responses, rather than cell migration (51, 52).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BLT1R", "is", "well", "known", "to", "mediate", "chemotaxis", "of", "leukocytes", "in", "response", "to", "LTB4", "(", "50", ")", ",", "while", "the", "ubiquitously", "expressed", "BLT2R", "is", "more", "involved", "in", "regulating", "inflammatory", "responses", ",", "rather", "than", "cell", "migration", "(", "51", ",", "52", ")", "." ] } ]
PMC10914904	This binding initiates the JAK/STAT (Janus kinase-signal transducer and activator of transcription) signaling pathway, which promotes the transcription of more than 300 interferon-stimulated genes (ISGs), which have diverse functions and contribute to an efficient antiviral response [3–6].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "binding", "initiates", "the", "JAK/STAT", "(", "Janus", "kinase-signal", "transducer", "and", "activator", "of", "transcription", ")", "signaling", "pathway", ",", "which", "promotes", "the", "transcription", "of", "more", "than", "300", "interferon-stimulated", "genes", "(", "ISGs", ")", ",", "which", "have", "diverse", "functions", "and", "contribute", "to", "an", "efficient", "antiviral", "response", "[", "3–6", "]", "." ] } ]
PMC11683240	Effect of different preincubation schemes of α1AT on PT-intoxication and binding of PT to cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Effect", "of", "different", "preincubation", "schemes", "of", "α1AT", "on", "PT-intoxication", "and", "binding", "of", "PT", "to", "cells", "." ] } ]
PMC11763533	The comparison of bioluminescence of fibroblasts transfected with pCMV constructs harboring three different pH-sensitive firefly luciferases showed that Amydetes luciferase (AmyLuc) displayed the best bioluminescence properties as a reporter gene and as pH-ratiometric indicator for mammalian cell bioimaging at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "comparison", "of", "bioluminescence", "of", "fibroblasts", "transfected", "with", "pCMV", "constructs", "harboring", "three", "different", "pH-sensitive", "firefly", "luciferases", "showed", "that", "Amydetes", "luciferase", "(", "AmyLuc", ")", "displayed", "the", "best", "bioluminescence", "properties", "as", "a", "reporter", "gene", "and", "as", "pH-ratiometric", "indicator", "for", "mammalian", "cell", "bioimaging", "at", "37", "°", "C", "." ] } ]
PMC11467964	Two hundred twenty‐three corresponding BMRGs were retrieved from previous studies as candidate gene sets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "hundred", "twenty‐three", "corresponding", "BMRGs", "were", "retrieved", "from", "previous", "studies", "as", "candidate", "gene", "sets", "." ] } ]
PMC11021472	To confirm effective binding of miR-150 to exogenous circZDHHC11, we performed an AGO2 RNA immunoprecipitation experiment upon overexpression of circZDHHC11 in DG75 cells, in the absence or presence of miR-150 overexpression (Supplemental Fig. 6D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "confirm", "effective", "binding", "of", "miR-150", "to", "exogenous", "circZDHHC11", ",", "we", "performed", "an", "AGO2", "RNA", "immunoprecipitation", "experiment", "upon", "overexpression", "of", "circZDHHC11", "in", "DG75", "cells", ",", "in", "the", "absence", "or", "presence", "of", "miR-150", "overexpression", "(", "Supplemental", "Fig.", "6D", ")", "." ] } ]
PMC9592219	Due to the insidious onset and rapid progression of PLC, many patients are diagnosed at an advanced stage .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", "to", "the", "insidious", "onset", "and", "rapid", "progression", "of", "PLC", ",", "many", "patients", "are", "diagnosed", "at", "an", "advanced", "stage", "." ] } ]
PMC10849234	Then, we stimulated the resultant NLCs and tested their ability to degranulate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", "we", "stimulated", "the", "resultant", "NLCs", "and", "tested", "their", "ability", "to", "degranulate", "." ] } ]
PMC9429973	One subgroup with DUX4 rearrangements and/or ERG deletions (DUX4-r/ERG-d) (n=78) had DUX4 involvement confirmed by WGS in 57 patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "subgroup", "with", "DUX4", "rearrangements", "and/or", "ERG", "deletions", "(", "DUX4-r/ERG-d", ")", "(", "n=78", ")", "had", "DUX4", "involvement", "confirmed", "by", "WGS", "in", "57", "patients", "." ] } ]
PMC9429973	Although we found no significant statistical difference in mortality between different ABO groups, certain haematological indices and biochemical markers of inflammation were favourable in patients with blood group AB with a tendency to lower mortality.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "we", "found", "no", "significant", "statistical", "difference", "in", "mortality", "between", "different", "ABO", "groups", ",", "certain", "haematological", "indices", "and", "biochemical", "markers", "of", "inflammation", "were", "favourable", "in", "patients", "with", "blood", "group", "AB", "with", "a", "tendency", "to", "lower", "mortality", "." ] } ]
PMC7570809	In 2016 we reported NMR and computational studies on the αvβ3 selective peptide, RGDechi, aiming to identify the molecular basis that regulates receptor recognition mechanism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "2016", "we", "reported", "NMR", "and", "computational", "studies", "on", "the", "αvβ3", "selective", "peptide", ",", "RGDechi", ",", "aiming", "to", "identify", "the", "molecular", "basis", "that", "regulates", "receptor", "recognition", "mechanism", "." ] } ]
PMC11366496	Data S1 show detailed information on antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "S1", "show", "detailed", "information", "on", "antibodies", "." ] } ]
PMC11594641	sEV-mediated crosstalk between cancer cells or between cancer cells and the tumor microenvironment delivers signaling molecules that induce tumor development, invasion, metastasis, and drug resistance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "sEV-mediated", "crosstalk", "between", "cancer", "cells", "or", "between", "cancer", "cells", "and", "the", "tumor", "microenvironment", "delivers", "signaling", "molecules", "that", "induce", "tumor", "development", ",", "invasion", ",", "metastasis", ",", "and", "drug", "resistance", "." ] } ]
PMC10631132	Cells with a stellar-like cell morphology can be seen in the fibroblast-derived iPSC MB differentiation group (empty arrows in H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "with", "a", "stellar-like", "cell", "morphology", "can", "be", "seen", "in", "the", "fibroblast-derived", "iPSC", "MB", "differentiation", "group", "(", "empty", "arrows", "in", "H", ")", "." ] } ]
PMC11607638	Long‐lasting activation of G protein‐coupled CCK or CCK‐like (SK) receptors might be an evolutionarily conserved property of this particular member of the rhodopsin‐like or A class GPCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Long‐lasting", "activation", "of", "G", "protein‐coupled", "CCK", "or", "CCK‐like", "(", "SK", ")", "receptors", "might", "be", "an", "evolutionarily", "conserved", "property", "of", "this", "particular", "member", "of", "the", "rhodopsin‐like", "or", "A", "class", "GPCR", "." ] } ]
PMC11087055	The above data indicate the lack of a strong relationship between the polonaise movements and PS morphogenesis; however, it remained unclear how the polonaise movements were induced.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "above", "data", "indicate", "the", "lack", "of", "a", "strong", "relationship", "between", "the", "polonaise", "movements", "and", "PS", "morphogenesis", ";", "however", ",", "it", "remained", "unclear", "how", "the", "polonaise", "movements", "were", "induced", "." ] } ]
PMC11543853	Subsequently, the separate maps of membranes and microfilaments were overlaid with the volumes of virions, empty particles, ribosomes, and microtubules and the original tomogram using ChimeraX (UCSF ChimeraX, version 1.3 (2021-12-08)).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequently", ",", "the", "separate", "maps", "of", "membranes", "and", "microfilaments", "were", "overlaid", "with", "the", "volumes", "of", "virions", ",", "empty", "particles", ",", "ribosomes", ",", "and", "microtubules", "and", "the", "original", "tomogram", "using", "ChimeraX", "(", "UCSF", "ChimeraX", ",", "version", "1.3", "(", "2021", "-", "12", "-", "08", ")", ")", "." ] } ]
PMC9429973	Methods: Study BCX9930-101 enrolled subjects with PNH with either no history of C5 INH use or those with an IR to C5 INH (defined as having a transfusion within 3 months of screening or Hb <10 g/dL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Study", "BCX9930", "-", "101", "enrolled", "subjects", "with", "PNH", "with", "either", "no", "history", "of", "C5", "INH", "use", "or", "those", "with", "an", "IR", "to", "C5", "INH", "(", "defined", "as", "having", "a", "transfusion", "within", "3", "months", "of", "screening", "or", "Hb", "<", "10", "g/dL", ")", "." ] } ]
PMC3164356	Paired-end Illumina reads of varying insert sizes were used for the de novo assembly of CHO-K1 (Supplementary Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Paired-end", "Illumina", "reads", "of", "varying", "insert", "sizes", "were", "used", "for", "the", "de", "novo", "assembly", "of", "CHO-K1", "(", "Supplementary", "Table", "1", ")", "." ] } ]
PMC9847912	CEMss cells from continuously-replicating cultures were seeded in 96-well Nunc™ Edge 2.0 microtiter plates (Thermo Fisher Scientific) at 2 × 10 cells per well in 150 μl per well of complete IMDM containing 20 μg/ml DEAE-dextran.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CEMss", "cells", "from", "continuously-replicating", "cultures", "were", "seeded", "in", "96-well", "Nunc", "™", "Edge", "2.0", "microtiter", "plates", "(", "Thermo", "Fisher", "Scientific", ")", "at", "2", "×", "10", "cells", "per", "well", "in", "150", "μl", "per", "well", "of", "complete", "IMDM", "containing", "20", "μg/ml", "DEAE-dextran", "." ] } ]
PMC9221284	All the primers that were used in this work are listed in Table 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "the", "primers", "that", "were", "used", "in", "this", "work", "are", "listed", "in", "Table", "1", "." ] } ]
PMC11724582	Stained colonies were recorded and analyzed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Stained", "colonies", "were", "recorded", "and", "analyzed", "." ] } ]
PMC11638288	On the other hand, HA inhibited the activation of NKp30 and stimulated the activation of NKp46.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "the", "other", "hand", ",", "HA", "inhibited", "the", "activation", "of", "NKp30", "and", "stimulated", "the", "activation", "of", "NKp46", "." ] } ]
PMC11703992	The bulk-seq data GSE174694 profiled using GPL18573 platform, which contains 40 GCA samples and 31 normal samples, was downloaded for external validation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "bulk-seq", "data", "GSE174694", "profiled", "using", "GPL18573", "platform", ",", "which", "contains", "40", "GCA", "samples", "and", "31", "normal", "samples", ",", "was", "downloaded", "for", "external", "validation", "." ] } ]
PMC11787381	Bambuterol (HCl) was purchased from Interchim (Montluçon, France).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bambuterol", "(", "HCl", ")", "was", "purchased", "from", "Interchim", "(", "Montluçon", ",", "France", ")", "." ] } ]
PMC11352666	Cell lysates were prepared in 150 mmol/L NaCl, 50 nmol/L HEPES pH 7.5, 10 mmol/L EDTA, 10% glycerol, 1% Triton X-100, and a protease inhibitor cocktail (ref 5892970001, Millipore Sigma, Darmstadt, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "lysates", "were", "prepared", "in", "150", "mmol/L", "NaCl", ",", "50", "nmol/L", "HEPES", "pH", "7.5", ",", "10", "mmol/L", "EDTA", ",", "10", "%", "glycerol", ",", "1", "%", "Triton", "X-100", ",", "and", "a", "protease", "inhibitor", "cocktail", "(", "ref", "5892970001", ",", "Millipore", "Sigma", ",", "Darmstadt", ",", "Germany", ")", "." ] } ]
PMC9429973	The real-world experience in day-to-day practice is limited.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "real-world", "experience", "in", "day-to-day", "practice", "is", "limited", "." ] } ]
PMC11536589	When a tumor mass formed on Day 3, mice were administrated with 1 mg/Kg MRTX1133 through intraperitoneal injection once every day, 1 mg/Kg PKF-118-310 through intratumoral injection once every three days, or combined treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "a", "tumor", "mass", "formed", "on", "Day", "3", ",", "mice", "were", "administrated", "with", "1", "mg/Kg", "MRTX1133", "through", "intraperitoneal", "injection", "once", "every", "day", ",", "1", "mg/Kg", "PKF-118", "-", "310", "through", "intratumoral", "injection", "once", "every", "three", "days", ",", "or", "combined", "treatment", "." ] } ]
PMC11543935	Adding spheroids into the hydrogels like in a study from Kim et al. could be used to train physicians to detect tumor sites.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Adding", "spheroids", "into", "the", "hydrogels", "like", "in", "a", "study", "from", "Kim", "et", "al.", "could", "be", "used", "to", "train", "physicians", "to", "detect", "tumor", "sites", "." ] } ]
PMC11787381	Therapeutic treatment of Alzheimer’s disease (AD) is currently experiencing unprecedented advances with the introduction by the US Food and Drug Administration (FDA) of several antibodies (aducanumab, lecanemab and donanemab) directed against amyloid β-oligomers and fibrils.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therapeutic", "treatment", "of", "Alzheimer", "’s", "disease", "(", "AD", ")", "is", "currently", "experiencing", "unprecedented", "advances", "with", "the", "introduction", "by", "the", "US", "Food", "and", "Drug", "Administration", "(", "FDA", ")", "of", "several", "antibodies", "(", "aducanumab", ",", "lecanemab", "and", "donanemab", ")", "directed", "against", "amyloid", "β-oligomers", "and", "fibrils", "." ] } ]
PMC11089031	Features of the tumor microenvironment heavily affect disease biology and may affect responses to systemic therapy especially immunotherapy [50–53].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Features", "of", "the", "tumor", "microenvironment", "heavily", "affect", "disease", "biology", "and", "may", "affect", "responses", "to", "systemic", "therapy", "especially", "immunotherapy", "[", "50–53", "]", "." ] } ]
PMC9275501	Meng et al. (2016a) co-encapsulated Res and PTX in PEGylated liposomes, which could produce strong cytotoxicity to drug-resistant MCF-7/ADR tumor cells in vitro, and improve the bioavailability of drugs and tumor retention ability in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Meng", "et", "al.", "(", "2016a", ")", "co-encapsulated", "Res", "and", "PTX", "in", "PEGylated", "liposomes", ",", "which", "could", "produce", "strong", "cytotoxicity", "to", "drug-resistant", "MCF-7/ADR", "tumor", "cells", "in", "vitro", ",", "and", "improve", "the", "bioavailability", "of", "drugs", "and", "tumor", "retention", "ability", "in", "vivo", "." ] } ]
PMC11352746	With this addition, neurite length can be measured by using phase-contrast images that do not disturb the culture when captured.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "this", "addition", ",", "neurite", "length", "can", "be", "measured", "by", "using", "phase-contrast", "images", "that", "do", "not", "disturb", "the", "culture", "when", "captured", "." ] } ]

PMC11562028

All the mice were randomly divided into 4 groups (n = 5): control group, model group, 5-FU group, and Re-CDs group.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "the", "mice", "were", "randomly", "divided", "into", "4", "groups", "(", "n", "=", "5", "):", "control", "group", ",", "model", "group", ",", "5-FU", "group", ",", "and", "Re-CDs", "group", "." ] } ]

PMC11337594

A375 and CASP3-KO cells were treated with TER (2.0 µg/ml) or DMSO for 24 h, and then labeled with Annexin V-FITC/PI for observation under a fluorescence microscope. (

[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A375", "and", "CASP3-KO", "cells", "were", "treated", "with", "TER", "(", "2.0", "µg/ml", ")", "or", "DMSO", "for", "24", "h", ",", "and", "then", "labeled", "with", "Annexin", "V-FITC/PI", "for", "observation", "under", "a", "fluorescence", "microscope", ".", "(" ] } ]

PMC8526701

Bromodomain proteins can further be subdivided into two families, the BET and non-BET families, on the basis of their structural parameters .

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PMC11640247

These observations underscore the complexity of RAC3 signaling pathways and suggest that similar migration phenotypes may result from distinct molecular mechanisms.

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PMC11802929

Note that two of the expressed SCT constructs were not included for 10X experiment due to low sample volume.

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PMC9429973

NLR was no longer significant in multivariate analysis.

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PMC5839394

After 24 h cells were incubated for 24 h with the IC50 concentration of the AgNPs-EPS, and observed for morphological changes assessment under a phase contrast inverted microscope (Carl Zeiss) at 400X magnification.

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PMC11269933

In vivo phosphorylation assay of different CgERK1/2 mutants on CgPK Ser11 site.

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PMC11721277

NMR spectra were obtained on a Bruker DPX300 spectrometer (Bruker Corporation, Billerica, MA, USA) using CDCl3 and DMSO-d6 as solvents.

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PMC9429973

A web-based online tool based on this algorithm rapidly identifies the bleeding risk profile of ITP patients to support clinical decision-making and reduce the occurrence of adverse outcomes.

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PMC11352311

We first analyzed the 47 esculin targets identified from SwissTargetPrediction and the 2085 RCC targets obtained from the GeneCards database using Venn diagrams, identifying 22 intersecting genes (Supplementary Table S1) (Figure 1B).

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PMC11594641

Previously, Rab27A was found to control the secretion of sEVs in mouse B16-F10 and human SkMel28 melanoma cells and to promote primary tumor growth in mice .

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PMC11049294

Incubation of GLA KO Jurkat cells with 2.83 nmol/mL Fl-Gb3 showed the same pattern of substrate accumulation as the DGJ-specific AGAL inhibitor-treated WT Jurkat cells.

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PMC11612794

The cells images were acquired by the confocal microscopy with spinning-disc.

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PMC9429973

Moreover, 6 out of 11 (55%) mutations identified in the PPCs were observed in cfDNA and BM (Figure 1A).

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PMC8345486

The results of two viability tests (NR and ATP measurement) are consistent: compound 23 exhibited high cytotoxicity independent of platinum resistance to adherent cells.

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PMC11224206

Hansen , Mietkiewska et al. and Khan et al. have provided excellent accounts of such research and the prospects of it leading to new strategies to mitigate the effects of overheating.

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PMC11122631

For the medicinal chemistry of the compounds, we evaluated four indicators, including Pan Assay Interference Structures (PAINS), Brenk, lead likeness, and the synthetic accessibility score (Table S20).

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PMC10968586

In fact, in vivo, 50 mg/kg, 100 mg/kg, and 200 mg/kg OLE showed a dose-dependent antioxidant activity, accounting for amelioration of cisplatin-induced pancreatic, liver, lung, and stomach damage in Spraque–Dawley rats .

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PMC10073922

No significant difference was observed between the viability of control and mock groups (p=0.243).

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PMC7229095

This practice will also decrease both time and effort, eliminating the need to adapt cells in new media and optimize the production media process.

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PMC9429973

Cases meeting ≥3 criteria within a 10-day period during the first 12 months after alloHCT were considered potential TA-TMA and were further evaluated by 2 clinicians from each transplant center.

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PMC11033180

In addition, mice invalidated for Sema5A exhibit ASD-like behaviors and several brain abnormalities including defects in axonal elongation and synaptic activity.

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PMC11585565

In silico functional prediction of p.(Gly492Cys), p.(Gly492Asp), and p.(Thr495Ile) variant in CNNM4 protein. (

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PMC9429973

Grade 3 or higher TEAEs were reported in 30 pts (53%), with neutropenia and increased ALT in 5 pts (9%) being the most frequent.

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PMC11684821

It is not yet known whether other allelic variants of MR1 affect protein function or expression levels.

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PMC11352746

Cell viability assays have a wide choice of methods, including the MTT assay, Cell Titer-Glo assay, and Ethidium homodimer assay .

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PMC9583612

Finally, emissions across multiple rounds on the same day were averaged to estimate a daily average emission rate for each facility (see Section S4).

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PMC8170755

Nevertheless, modulation of multiple growth factors and matrix metalloproteinases (MMPs) may be involved (6).

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PMC7305184

Variation between generations is present at the slope of survival curve (Fig. 3).

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PMC11049548

At the level of the endo-metabolome, there are several features that cause HGSOC_T and HGSOC_A cells to occupy a characteristic position in the “metabolic space”, which is intermediate between those of A2780 and A2780cis cells (see PCA score plot in Figure 3A).

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PMC11045125

These results confirm that decreased Src and STAT3 expression in ΔEBNA2 + Myc tumors is an important mechanism by which Myc turns off LMP1 expression.

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PMC11727638

Another method of collecting cells that behave similarly to Cell Dome cultured cells in a short period involves miniaturizing the Cell Dome by mechanizing its preparation process and changing the size of the water-repellent ring pattern printed on the glass plates.

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PMC11612794

Immunoprecipitated samples were subjected to immunoblot analyses using anti-CENP-T, anti-FLAG, and anti-Dsn1 antibodies.

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PMC11804588

This tool substantially enhances our ability to dissect gene regulatory networks in diverse cell types of multicellular organisms.

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PMC10203589

The proportion of S-phase number of cells increased significantly with the stimulation of FGF18, and the angiogenic activity of SW480 cells was increased.

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PMC9812014

NDV causes infections in poultry farming birds, and it is a persistent threat to the poultry industry all over the world .

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PMC10999934

The prognostic value of shared genes for high-grade serous ovarian cancer was assessed with KM plotter (http://kmplot.com/analysis).

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PMC11746948

Collectively, these results establish APT2 as the regulatory enzyme of GPX4 depalmitoylation.

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PMC9812014

1Structures of some antiviral alkaloids Structures of some antiviral alkaloids In this review, the antiviral role of some alkaloids of different origins against a variety of viruses is presented.

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PMC11496491

In terms of molecular function, differential genes are most significantly enriched in terms of protein binding, ion binding, and protein domain specific binding.

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PMC11743414

Rabbit anti-FHL1 (1:1000; Proteintech, Wuhan, China) and rabbit anti-β-tubulin (1:5000; Abcam, Cambridge, UK) were incubated overnight at 4 °C.

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PMC11674891

In datasets GSE50081, GSE19188, and GSE14814, higher GRPR expression was associated with poorer overall survival rates (p = 2.8 × 10 for GSE50081 (N = 181); p = 2.7 × 10 for GSE19188 (n = 82); p = 9.9 × 10 for GSE14814 (n = 89), log-rank test).

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PMC11792090

In the Jurkat reporter cells, a luciferase reporter gene was placed under the control of a nuclear factor of activated T cells (NFAT)-responsive promoter.

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PMC11173119

We further differentiated these cells into macrophage-like cells.

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PMC6312945

HBV infection is the main cause of liver cancer.

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PMC9429973

61/201 pts were selected in the MM treatment (tto) protocols.

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PMC10849234

HL-60 (A-D) or PLB-985 (E-H) cells were differentiated into Neutrophil-like cells (NLCs) with DMSO, in addition to either G-CSF or Nutridoma and then left unstimulated (unstim), or stimulated with cytochalasin B and fMLP (fMLP).

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PMC7022782

The increase in ICG concentration led to a growth in the peak fluorescence intensity up to a maximum value of dye amount of 2.5 µg/mL. This was followed by a decrease in the peak fluorescence intensity when the dye concentration is increased.

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PMC11188874

Effect of HDAC6 KO on proteasome activity and antigen presentation A, SDS-PAGE of lysates from HDAC6 KO in MMCLs RPMI-8226, U266, and ARH-77.

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PMC11705862

The following day the sections were incubated in Ig Impress reagent kit secondary anti-rabbit antibody (Vector Laboratories #MP-7401) at RT for 2 h, and then developed for 2 min in 0.25 mg/ mL diaminobenzidine and 0.012% H2O2.

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PMC11761919

The values represent mean ± SD.

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PMC11724582

Additionally, CAFs enhanced the survival of almonertinib-treated NSCLC cells, whereas normal fibroblasts (NFs) exerted the opposite effect.

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PMC10965680

These initiatives include the establishment of conservation areas, conservation farms, and gene banks dedicated to preserving genetic resources of special breeds to safeguard indigenous animal populations for the benefit of future generations (Wei et al., 2014).

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PMC10243817

An ALI culture of HNECs were obtained from controls (5, 56).

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PMC11656048

According to the protocol, the cells were seeded in confocal dishes.

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PMC11013014

2-(2,3-dichloro-4-(2-methylenebutanoyl)phenoxy)-N-(1-methyl-1H-indol-5-yl)acetamide (4).

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PMC11470381

Avoid using confluent cells for transfection, as this can lead to decreased viability and transfection efficiencies.

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PMC9429973

Firstly, lymphomas are characterized by pronounced heterogeneity, with distinctive features depending on the biology of lymphoma subtype.

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PMC9429973

Furthermore, our analysis revealed segregation of patients by HOXA13 or ZFP36L2 rearrangements and NUP98/NUP214 fusions.

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PMC9429973

For example, a 50-year-old male diagnosed with HCL in 1990, on average, has a LEL of 3.8 years (95% confidence interval [CI]: 2.1-5.5), whereas a male with a HCL diagnosis in 2019, on average, has a LEL of 1.0 years (95% CI, 0.3-1.7).

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PMC8358006

Metagenes are centered on the H3K27me3 region (7.6 kb for typical peaks and 75.4 kb for grand H3K27me3 domains), with 3 kb surrounding each peak region.

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PMC11748335

On the right, a box plot represents the percentage for intergenic and promoter-TSS elements among peaks.

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PMC5261804

Specifically, we define the essentiality of node i (in the dual graph) at tth step by .

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PMC9429973

For assessment of adverse events (AEs) NCI CTCAE v. 4.0 was used.

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PMC11723947

As expected, the frequency of PD-1 and LAG-3-expressing cells and the average expression of these immune checkpoints were higher in HP1γ-deficient cells than in control cells (Fig. 6h, k).

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PMC9024365

Thus, it is tempting to speculate that SD4 captures AMPARs at the plasma membrane for clustering via transport through an endocytic compartment.

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PMC9878562

BLT1R is well known to mediate chemotaxis of leukocytes in response to LTB4 (50), while the ubiquitously expressed BLT2R is more involved in regulating inflammatory responses, rather than cell migration (51, 52).

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PMC10914904

This binding initiates the JAK/STAT (Janus kinase-signal transducer and activator of transcription) signaling pathway, which promotes the transcription of more than 300 interferon-stimulated genes (ISGs), which have diverse functions and contribute to an efficient antiviral response [3–6].

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PMC11683240

Effect of different preincubation schemes of α1AT on PT-intoxication and binding of PT to cells.

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PMC11763533

The comparison of bioluminescence of fibroblasts transfected with pCMV constructs harboring three different pH-sensitive firefly luciferases showed that Amydetes luciferase (AmyLuc) displayed the best bioluminescence properties as a reporter gene and as pH-ratiometric indicator for mammalian cell bioimaging at 37 °C.

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PMC11467964

Two hundred twenty‐three corresponding BMRGs were retrieved from previous studies as candidate gene sets.

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PMC11021472

To confirm effective binding of miR-150 to exogenous circZDHHC11, we performed an AGO2 RNA immunoprecipitation experiment upon overexpression of circZDHHC11 in DG75 cells, in the absence or presence of miR-150 overexpression (Supplemental Fig. 6D).

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PMC9592219

Due to the insidious onset and rapid progression of PLC, many patients are diagnosed at an advanced stage .

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PMC10849234

Then, we stimulated the resultant NLCs and tested their ability to degranulate.

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PMC9429973

One subgroup with DUX4 rearrangements and/or ERG deletions (DUX4-r/ERG-d) (n=78) had DUX4 involvement confirmed by WGS in 57 patients.

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PMC9429973

Although we found no significant statistical difference in mortality between different ABO groups, certain haematological indices and biochemical markers of inflammation were favourable in patients with blood group AB with a tendency to lower mortality.

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PMC7570809

In 2016 we reported NMR and computational studies on the αvβ3 selective peptide, RGDechi, aiming to identify the molecular basis that regulates receptor recognition mechanism.

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PMC11366496

Data S1 show detailed information on antibodies.

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PMC11594641

sEV-mediated crosstalk between cancer cells or between cancer cells and the tumor microenvironment delivers signaling molecules that induce tumor development, invasion, metastasis, and drug resistance .

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PMC10631132

Cells with a stellar-like cell morphology can be seen in the fibroblast-derived iPSC MB differentiation group (empty arrows in H).

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PMC11607638

Long‐lasting activation of G protein‐coupled CCK or CCK‐like (SK) receptors might be an evolutionarily conserved property of this particular member of the rhodopsin‐like or A class GPCR.

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PMC11087055

The above data indicate the lack of a strong relationship between the polonaise movements and PS morphogenesis; however, it remained unclear how the polonaise movements were induced.

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PMC11543853

Subsequently, the separate maps of membranes and microfilaments were overlaid with the volumes of virions, empty particles, ribosomes, and microtubules and the original tomogram using ChimeraX (UCSF ChimeraX, version 1.3 (2021-12-08)).

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PMC9429973

Methods: Study BCX9930-101 enrolled subjects with PNH with either no history of C5 INH use or those with an IR to C5 INH (defined as having a transfusion within 3 months of screening or Hb <10 g/dL).

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PMC3164356

Paired-end Illumina reads of varying insert sizes were used for the de novo assembly of CHO-K1 (Supplementary Table 1).

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PMC9847912

CEMss cells from continuously-replicating cultures were seeded in 96-well Nunc™ Edge 2.0 microtiter plates (Thermo Fisher Scientific) at 2 × 10 cells per well in 150 μl per well of complete IMDM containing 20 μg/ml DEAE-dextran.

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PMC9221284

All the primers that were used in this work are listed in Table 1.

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PMC11724582

Stained colonies were recorded and analyzed.

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PMC11638288

On the other hand, HA inhibited the activation of NKp30 and stimulated the activation of NKp46.

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PMC11703992

The bulk-seq data GSE174694 profiled using GPL18573 platform, which contains 40 GCA samples and 31 normal samples, was downloaded for external validation .

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PMC11787381

Bambuterol (HCl) was purchased from Interchim (Montluçon, France).

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PMC11352666

Cell lysates were prepared in 150 mmol/L NaCl, 50 nmol/L HEPES pH 7.5, 10 mmol/L EDTA, 10% glycerol, 1% Triton X-100, and a protease inhibitor cocktail (ref 5892970001, Millipore Sigma, Darmstadt, Germany).

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PMC9429973

The real-world experience in day-to-day practice is limited.

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PMC11536589

When a tumor mass formed on Day 3, mice were administrated with 1 mg/Kg MRTX1133 through intraperitoneal injection once every day, 1 mg/Kg PKF-118-310 through intratumoral injection once every three days, or combined treatment.

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PMC11543935

Adding spheroids into the hydrogels like in a study from Kim et al. could be used to train physicians to detect tumor sites.

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PMC11787381

Therapeutic treatment of Alzheimer’s disease (AD) is currently experiencing unprecedented advances with the introduction by the US Food and Drug Administration (FDA) of several antibodies (aducanumab, lecanemab and donanemab) directed against amyloid β-oligomers and fibrils.

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PMC11089031

Features of the tumor microenvironment heavily affect disease biology and may affect responses to systemic therapy especially immunotherapy [50–53].

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PMC9275501

Meng et al. (2016a) co-encapsulated Res and PTX in PEGylated liposomes, which could produce strong cytotoxicity to drug-resistant MCF-7/ADR tumor cells in vitro, and improve the bioavailability of drugs and tumor retention ability in vivo.

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PMC11352746

With this addition, neurite length can be measured by using phase-contrast images that do not disturb the culture when captured.

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