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PMC5963610
Following the same schedule of treatment presented in Figure 1A, the number of infiltrate immune cell in 3LL-metastases (at day 52) was quantified by immunohistochemistry.
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PMC11388384
Cells were imaged on 5 z-planes spanning 3.6 µm, and cytonemes were counted manually in each plane using FIJI.
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PMC11361748
Scale bars: 50 μm.
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PMC10033453
Although WEHI 164 showed significantly reduced viability in the MTS assay after VMG infection, tumor growth was not affected in the subcutaneous model after 3 doses of virus.
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PMC9429973
Results: As of October 26, 2021, 15 patients were enrolled, and 11 (73%) received ≥4 cycles of Pola-R-GemOx.
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PMC10362265
We have modeled the human IL18-IL18BP complex structure from scratch by AlphaFold2 and molecular modeling methods.
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PMC11422497
RT-qPCR, reverse transcription- quantitative PCR.
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PMC10560648
Marine ecosystems have long been described as an unfinished biologically active resource with extensive medicinal properties.
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PMC11380454
Thus, in addition to effective immune stimulation, inhibition of the PD-1/PD-L1 axis may be a novel approach to decrease drug resistance in cancer and, therefore, increase the efficacy of chemotherapy.
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PMC11075223
The following were examples of the anticancer effect of monomer components.
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PMC5925824
Each data point represents the average of 8 replicates, with error bars representing the SEM.
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PMC11637276
Integrin signalling has mainly been associated with Src, focal adhesion kinase (FAK) and epidermal growth factor receptor (EGFR) activation, resulting in cell adhesion, proliferation, and migration [63–65].
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PMC9429973
Pts may be treated with 1 of 4 tyrosine kinase inhibitors (TKIs) approved for 1st-line (1L) use: the 1st-generation TKI imatinib and the 2nd-generation (2G) TKIs bosutinib, dasatinib, and nilotinib.
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PMC11411004
c Live cell density.
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PMC9429973
Table 1 Results: No relevant bleeding events were documented and all procedures were successfully completed.
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PMC11095939
Data are presented as means ± SEM; n = 3.
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PMC9429973
Causes of death during treatment were multiple: respiratory disease due to the differentiation syndrome, a severe haemorrhagic syndrome and or septic shock.
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PMC9429973
Higher levels of ctDNA (≥2.5 log hGE/mL) were associated with a significantly worse PFS (p=0.025) and OS (p=0.004).
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PMC5963610
4T1: BALB/c mice were transplanted subcutaneously (s.c.)
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PMC11748335
G In the NE2-KYSE450 pair, the H3K27me3 intensity, DNA methylation, gene expression, H3K27ac intensity, and H3K4me3 intensity of upregulated or hypermethylated CGI promoters.
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PMC11271278
A–C Plotted are the calculated trans-enhancer contribution (x-axis) and the copy number estimated by SNP-array data (y-axis) for each HAPI gene in NCIH2170, NCIH446, and MCF7 cells.
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PMC7215722
Another piecec of evidence for the distortion of LR is provided by the substantial reduction in the enzymatic activity of SI that is normally higher in LR than in non-LR .
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PMC9436459
Structurally, classic MDAAs share the same chalcone-skeleton dienophiles but differ in the dehydroprenylphenol dienes.
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PMC11583010
When tumors reached 150 to 200 mm, both tumor-bearing and naïve animals were injected intravenously with a single dose of ETx-22.
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PMC10759659
f Immunohistochemical staining for TIM3 expression within patients carry ARID1A mutation or not.
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PMC10154881
The induction of NK‐cell activation was observed previously with MV‐based or adenovirus‐based oncolytic virus infection to cancer cells in vitro. ,
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PMC2614416
The distributions are clearly characterized by diversity in EC, and dominated by traceable author statement (TAS), inferred from electronic annotation (IEA), and inferred from direct assay (IDA); these being the topmost ranks in the hierarchy of evidence codes .
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PMC11119602
In order to develop cisplatin-resistant cell lines, cisplatin toxicity curves were constructed using the CCK-8 Cell Counting Kit-8 assay (Section 2.3).
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PMC9429973
Methods: Patients with SAMD9 or SAMD9L mutation and monosomy 7, younger than 5 years of age, were closely monitored with bone marrow morphology, SAMD9/9L mutational analysis and cytogenetic studies every 3-4 month.
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PMC11469524
Thus, the well-known RAF->MEK->ERK-|RAF regulatory loop also exists in BLs and DLBCLs, whereas the negative impact of BCR mediated p38 activation onto this loop is a newly discovered crosstalk found in three BL cell lines BL-2, BL-41 and CA-46 and one DLBCL cell line HBL-1.
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PMC11705484
Subsequently, 5637 cells were treated with SN50, an NF‐κB inhibitor, which decreased p65 protein expression and phosphorylation (p‐NF‐κB, p‐p65) and reduced TRMT61A protein expression.
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PMC9739791
PI and Hoechst 33342 (red and blue staining, respectively) were used to visualize DNA.
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PMC11449273
Cultures were seeded at 7,500 cells in 35 mm culture plates containing 0.6% base agar and 0.35% top agar (Noble Agar, Thermo Scientific) in CMEM.
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PMC11348300
Once pressure is released, blood flow slowly returns to the tumor due to its intrinsic pressure and compromised blood perfusion.
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PMC9693627
Cells were sorted using FACS Aria SORP (Beckton Dickinson Biosciences, East Rutherford, NJ, USA).
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PMC11484188
no. P0015F; Beyotime, Inc.) and boiled at 100˚C for 10 min, after which, 50 µg protein/lane were subjected to separation by 10% SDS-PAGE and transferred onto a PVDF membrane at a constant voltage of 110 V. After blocking the membrane with 5% skimmed milk powder for 2 h at room temperature, the following primary antibodies were added overnight at 4˚C: Anti-GAPDH (cat.
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PMC9429973
Methods: Health-related quality of life was examined by patient-reported outcomes (PROs) measures assessed by EORTC QLQ-C30 and EQ-5D-5L at baseline, Cycle 1, and then every 3rd cycle until end of treatment.
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PMC11697065
High and low qP clones were identified for all cell lines apart from BisAb2 where no high secreting clones were found (Fig. 3B).
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PMC9532503
The operating parameters used for this purification step are listed in Supplementary Table 1.
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PMC9444294
Cells were then physically homogenized on ice to obtain nuclear lysates, which were incubated with digestion buffer for 5 min at 37°C, followed by incubation with the provided Enzymatic Shearing Cocktail for an optimized timepoint.
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PMC10006224
All experiments were performed three times with similar results.
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PMC10482220
The intensity of each spot from untreated (blue) and arsenite-treated (red) was quantitated by densitometry scanning of the chromatography plates using ImageQuant software version 5.2.
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PMC11515150
12 C CAR-NK cells and NT-NK cells were cocultured with auto normal T cells (top panel) and two donors’ normal T cells (T1, T2; bottom panels) overnight at the indicated E: T ratio (n = 3; two-way ANOVA; ***p < 0.001, ****p < 0.0001).
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PMC9895440
Along this line, Tex showed pronounced upregulation of cluster 1, which contains PDCD1 (PD-1), TOX2, and PTPN6 (SHP-1) – transcripts that are associated with T cell exhaustion and PD-1 signaling.
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PMC11746948
Palmitoylation plays a pivotal role in regulating protein function, localization, stability, and signaling pathways.
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PMC11344246
RNA sequencing libraries were generated using the same library preparation as the tumours (NEBNext Ultra II Directional Library Prep Kit (New England BioLabs) with ribo-depletion).
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PMC11761919
Inulin has been reported to control hyperglycemia and high cholesterol, in addition to its prebiotic effects (Lemarchand et al., 2004).
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PMC11310713
OVX rats also showed a decline in Tb.
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PMC10158546
Summary of ReN cell lines.
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PMC11597291
According to DLS, the average size (hydrodynamic diameter) of the nCGO was around 80 nm, while the average size of the nCGO-PEG particles ranged between 100 and 180 nm.
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PMC11095939
Because the liver is a key metabolic organ, we paid particular attention to Mecp2-regulated NRs, whose alteration may result in a shift in the balance between metabolism and proliferation.
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PMC11401350
By simultaneously abolishing natural receptor usage in these gps, gene delivery to non-target (e.g. malignant) cells is abolished .
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PMC11756514
S. aureus Reynolds is a well-characterized strain for assessing the biological properties of CP; it produces CP5.
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PMC9429973
The COO categorization was carried out on the Nanostring platform applying the Lymphoma subtyping test(LST) algorithm.
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PMC7987994
Besides, many authors do not specify the medium, e.g., some claim only “DMEM medium”, without further specification of glucose concentration or additional buffer content.
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PMC11473843
Dotplot showing the results of KEGG pathway enrichment analysis of genes that are activated or suppressed in A549 treated with XMD8-92 and Seliciclib in combination (10 µM). (
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PMC10380508
Cells were sub-cultured when the confluence reached 90%.
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PMC11767582
While there has been significant progress in our understanding of the molecular mechanisms underlying this diverse group of diseases collectively referred to as ‘cancer’ (there are in fact more than 150 different types of cancer), the development of improved anti-cancer drugs is of pressing urgency.
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PMC9688728
The p-value of this pathway is 5.51 × 10, and match status is 9/22.
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PMC11653168
no. 9662S; Cell Signaling Technology, Inc.), LC3B (1:1,000; cat.
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PMC11765988
Tumor cells tend to produce energy in the initial stages through glycolysis rather than aerobic cellular respiration, even in the presence of oxygen.
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PMC11089031
We found a dataset containing 34326 cells in which the single-cell transcriptomes of cancer and immune cells isolated from patients with metastatic ccRCC before or after ICB therapy were characterized .
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PMC11476264
Importantly, the depletion of ZEB1 suppresses the increased migration and invasion of A549 and H1299 cells promoted by the depletion of FBXO11.
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PMC11670407
h, i 143B cells cotransfected with the indicated siRNA and overexpression plasmids for 48 h were treated with PBS or cisplatin (5, 10 or 15 μM) for 24 h. j Survival analysis of sarcoma patients in the TCGA database and GPX4 expression.
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PMC9429973
Hemoglobin oxygen affinity (p50) was measured with the Hemox Analyzer.
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PMC4695073
Subgroup survival analysis also demonstrated that XPA expression level had more prediction value on OS and PFS in the subgroups of EBV VCA-IgA>1:160 or EA-IgA>1:20, though EBV antibody titer alone wasn't correlative with prognosis in these 129 NPC patients (Figures 3A, 3C, 3D, 4A, 4C and 4D).
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PMC6379402
We apply it to construct cancer-specific iCells of the four most prevalent cancers in human, breast, prostate, lung, and colorectal, along with iCells of the corresponding control tissues.
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PMC11291697
Furthermore, glycine level affects L-serine one and the latter amino acid is the precursor of D-serine : the observed increase in proband’s LCL D-serine level could further induce NMDA receptor hyperactivation.
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PMC11473843
Conversely, the treatment with the FAKi alone inhibited tumor progression, while the combined treatment with FAKi + ERK5i led to tumor regression as shown by micro-computed tomography (μCT) of the mouse lungs (Fig. 6B).
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PMC9268183
The official monographs of the European Medicines Agency (EMA) and European Scientific Cooperative on Phytotherapy (ESCOP) include just one out of the forty-one species reported in our study.
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PMC10969097
Mushroom extracts have already been used to prevent and relieve symptoms in the treatment of both early-stage and advanced cancer treatments .
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PMC10073922
The results also exhibited increased cell death and apoptosis and decreased migration and invasion of A549 cells through inhibition of MMP-2 and MMP-9 expression.
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PMC9429973
Whereas, there is no statistical difference in the prognosis of 3 groups with diverse remission speed rates (PFS: P=0.35; OS: P=0.77).
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PMC11451940
Cellular effects of complexes 1, 5 and 7 in A2780 cells were investigated by flow cytometry revealing that the most cytotoxic complexes (1 and 5) significantly perturbed the mitochondrial membrane potential and the interaction with mitochondrial metabolism followed by the triggering of the intracellular pathway of apoptosis.
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PMC9473868
However, the therapeutic effect of BAI on RA is not fully understood .
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PMC7338939
In A375 with B-raf mutation, DAPT decreased the level of NOTCH1, NOTH2, and HES1 as downstream genes of the Notch pathway.
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PMC10589262
In addition, GIST exhibits MT-KIT folding stress .
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PMC11763111
The 4KO-LLT1 CAR-T cells demonstrated even greater potency that the 1KO CAR-T cells (Fig. 5G).
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PMC9352806
In all, 1190 and 1245 metabolites with identified names were detected in the positive and negative ion modes, respectively (Fig. S2).
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PMC11025866
However, since both HDAC inhibitors changed the expression of thousands of genes, it was not feasible to identify a cellular gene expression signature that was associated the capacity of VPA to inhibit initiation of EBV lytic reactivation.
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PMC11650848
All cells were incubated at 37 °C and in 5% CO2.
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PMC11740399
A previous study reported that metformin decreased the accumulation of PKM2 by suppressing the PI3K/AKT/mTOR signaling pathway in esophageal cancer cells ; we, therefore, determined the activity of PI3K/AKT/mTOR axis after treating the cells by 3025@ML.
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PMC11674441
Recent reports on neoantigen-based vaccine therapy have demonstrated significant effects in cases in which HLA class II-restricted neoantigen peptide-specific T cells were used .
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PMC9429973
The effect was reverted by AZD3965 treatment.
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PMC11052306
It has been shown, in particular, that serum copper concentration increases as the cancer disease progresses .
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PMC11283030
n = 3, *P < 0.05, **P < 0.01 vs. VC.
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PMC11680391
This study evaluated herd veterinarians’ udder health consulting skills by asking dairy farmers and herd veterinarians similar questions regarding the consulting process.
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PMC6160470
The nature of interaction between compound and transporter can be assessed by an in vitro P-gp-ATPase assay.
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PMC11700247
Unlike the A20 model, CT26 does not express CD19 but does express gp70, which can be recognized by gp70/AH1–specific T cells.
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PMC11718031
In this study we evaluated various basal media-feed combinations by examining key performance indicators such as viable cell count (VCC), viability, monoclonal antibody (mAb) concentration, and mAb N-glycosylation.
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PMC11300639
a–c A498 cells were infected with indicated shRNAs for 72 h. Cells were harvested and subjected to RNA-seq analysis (a).
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PMC7452526
To the best of our knowledge, this is the first report showing the potent anticancer of silver nanoparticles biosynthesized using AEECL extract against human colon cancer cells (Caco-2).
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PMC11291490
A schematic representation of pVAX-prM-E-dusCD40L can be observed in Fig. 4a.
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PMC11637276
The large cassette dispensed 50 μl ice-cold PBS in a 384-well plate.
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PMC9429973
Aims: This pivotal phase 3 study of MF patients (pts) previously treated with a JAK inhibitor (JAKi) tested MMB vs DAN on key symptom, anemia, and spleen volume endpoints at 24 weeks (wks).
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PMC9429973
Results: 36 patients (18 females, 18 males) aged 23 to 80 were followed up for a median 14 months.
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PMC11486946
Fig. 1Large-scale single-molecule imaging analysis of fluorescently labeled EGFR for drug screening.a Schematic flow of single-molecule imaging using AiSIS for drug screening.
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PMC10914904
In addition, vtRNAs adopt secondary structures that can be targets of interferon-inducible protein kinase R (PKR) and the oligoadenylate synthetase (OAS)/RNase L system, both of which are important for activating antiviral defenses.
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PMC11792090
When tumor volumes reached approximately 100 mm³, treatment was administered by intravenously injecting the indicated T cells in a volume of 200 μL. Tumor size, body weight, skin condition, fur quality, and posture of each mouse were continuously monitored.
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PMC11675244
Furthermore, nuclear β-catenin accumulation enhances cyclin D1 mRNA production, while GSK3β inactivation furtherly boosts cyclin D1 levels, which may partly contribute to its protein degradation .
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