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PMC6461034
The parameter is calculated by taking a goniometric correlate of the ratio of substrate‐centric and kinase‐centric evidence, and normalizing the corresponding angle on [0,π2] to give a value in .
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PMC5673955
The fluorescence was measured at the end of annealing step.
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PMC11594074
Photographs were taken at 0 h, 24 h, and 48 h using a JuLIT™Br Live Cell Movie Analyzer (NanoEnTek Inc., Seoul, Republic of Korea) at 1× magnification and 1/3700 s of exposure time.
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PMC9429973
A stepwise procedure allowed optimization of SCI identification, with distinction between SCI and non-clinically significant background (periventricular areas) or other white matter hyperintensities (transient glial maturation).
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PMC10568263
The other two fitted peaks at 86.0 and 89.6 eV are attributed to the Au(i) state.
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PMC2196094
The processed proteolytically active RMCP-7 is an acidic protein with a net charge of −4.6 (Arg + Lys = 17; Asp + Glu = 23). (
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PMC11755467
--R1 <untreated_R1_read_file>: Path to R1 read file for untreated samples.
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PMC9429973
Image: Summary/Conclusion: Once again, poor results are confirmed for this MDS/MPN overlap syndromes with only a third of the patients being long term survivors.
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PMC11352877
In contrast to the activity of VEGF, TGF-β1 induces the apoptosis of endothelial cells because, during angiogenesis, apoptosis is required to sever the newly formed vascular network, and its inhibition leads to the formation of abnormal vessels .
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PMC9577200
Total RNA was obtained from chitosan treated and untreated HeLa cell lines using EZNA reagent (OMEGA bio-TEKRE agent) and cDNA was reverse transcribed from RNA using Superscript II reverse transcriptase, according to the manufacturer's recommendations.
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PMC8759873
Phosphatidylserine in the normal cell membrane is inside the membrane, and Annexin-V-R-PE cannot stain it; the cell membrane is intact, 7-AAD cannot be stained, and the corresponding points are distributed in the Q3 area. (
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PMC11623887
Permissive cells expressed by the B19V receptor and coreceptors are permeable to the entrance of the virus but may be unable to support the virus replication and infection.
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PMC11366496
According to the protocols, cell proliferation assays were carried out with CCK‐8 (Cell Counting Kit‐8, Dojindo, Tokyo, Japan).
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PMC11574271
at the end of the assay, all samples were photographed and analyzed using confocal scanning microscopy (NOVEL, Ningbo, China).
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PMC9684669
A2780-ADR cells were seeded onto 96-well plates at a density of 5,000 cells/well.
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PMC11758416
Wash with sufficient volume of T cell media.
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PMC11023271
Indeed, our current study and other reports showed that LPA can drive the proliferation of keratinocyte-derived cell lines and LPA has been suggested to be a tumor promoter in esophageal squamous cell carcinomas, colorectal cancers, glioblastoma, ovarian cancers, and other cancers [28, 32–35] Our earlier study showed that the loss of RIPK4 in skin SCCs led to enhanced cell proliferation, probably due to upregulation of nuclear p63 and decreased NF-kB pathway activation .
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PMC8567602
Sup.,
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PMC11025866
Some lytic cycle activators, such as NaB and trichostatin A (TSA), are HDAC inhibitors.
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PMC11297139
Statistical analysis performed using a two-tailed Wilcoxon signed rank test on day 4 samples of ARID1A + WT, and ARID1A + ΔDD A673 cell lines.
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PMC11604015
In the following sections, we elaborate on the diverse target antigens and T cell sources of CAR-T cells that can potentially resolve the limitations of existing clinical trials.
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PMC11049548
Concerning the metabolism of individual amino acids, the HGSOC_T, HGSOC_A, and A2780cis cells show a strong reduction of the consumption of Asp and Glu from the media, and also the uptake of the branched-chain amino acids (Val, Ile, Leu) and of the aromatic amino acids (His, Phe and Tyr) is significantly reduced (Figure 3D and Figure 4) in comparison to A2780.
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PMC11082662
E,F) Invasion assay evaluating the decreased invasion of SK-OV-3 and HEY cells following SMPDL3B knockdown (100 µm).
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PMC11269792
Bioinformatics website to predict the potential targets of circAPP and miR-6838-5p, (B and C) Dual luciferase reporter assay and RIP assay to detect the targeting relationship between circAPP and miR-6838-5p, (D and E) miR-6838-5p expression in tissues and cells, (F) Effect of knockdown of circAPP on miR-6838-5p expression; data are expressed as mean ± SD (n = 3). *
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PMC11637276
The pooled siRNAs for each gene were deconvoluted into 4 individual siRNAs (S3 Table).
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PMC11577421
Furthermore, a competitive uptake assay in the presence of excess heparin showed reduced uptake for NP_BSA, whereas the uptake of NP_BSA+ was completely abolished, consistent with results observed in CHO-K1 cells.
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PMC11682224
Matrigel was added to 24-well plates and allowed to solidify.
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PMC11476666
Molecular assays after sorting confirmed a higher expression of the CSC markers SOX2 and CD44 in SP cells compared to both MP and non-sorted (NS) A549 cells used as control.
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PMC9436459
After protection of S143 with MOMCl, the resulting MOM-ether S144 was subjected to a regioselective formylation to afford benzaldehyde S145 in 83% yield over two steps.
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PMC11781181
However, whether exosomal miR-375-3p is involved in keratinocyte ferroptosis in SJS/TEN is largely unknown.
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PMC6468656
In our experiments, equivalent loads of 25–50 μg of protein were electrophoresed using a SDS-polyacrylamide gel and then electrophoretically transferred from the gel to a PVDF membrane (Millipore, Bedford, MA, USA).
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PMC11026382
Given that mutations tend to have similar epistatic effects at a particular DHFR position in our data set (Supplementary Fig. 4), we used k-means clustering to sort positions into four categories according to their pattern of epistasis: negative, insignificant, positive, and strong positive (Fig. 6a, Supplementary Table 4).
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PMC5925824
Tumor growth was monitored by caliper, and results are represented as a geometric mean of tumor volumes ± SEM.
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PMC10335954
Cells were washed with PBS, stained with 500 µl Giemsa (cat.
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PMC10938377
This depot association is likely fostered by hydrophobic interactions with GAG residues.
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PMC11585565
CNNM4 comprises 7 exons that encode the protein containing four domains: (1) the extracellular domain, (2) the transmembrane domain, also known as the domain of unknown function 21 or DUF21, (3) the CBS domain, and (4) the cyclic nucleotide-binding homology (CNBH) domain.
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PMC11682172
Prism 5.0 (GraphPad Software) was used to perform statistical tests.
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PMC11190238
a Genome-wide view of A and B compartments, colored red and blue respectively, in H1-hESC and its differentiated cell lines.
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PMC11119602
p values < 0.05 were considered statistically significant.
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PMC5916734
The reasons for the lower level of procoagulant activity recovery of recombinant FIX are yet to be elucidated, since comparative clinical trials evaluating the pharmacokinetics of nFIX products have shown that recombinant FIX has a longer half-life: 36 h for recombinant FIX versus 32.7 h for natural FIX .
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PMC9429973
Importantly, HDAC inhibition attenuates Fpn mRNA repression as well as the resulting hypoferremia in mice.
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PMC8097906
This is due to the reduced ability for S1P-directed chemoattraction induced by the irreversible SGPL1-mediated S1P cleavage to the non-sphingolipid molecules hexadecenal and ethanolamine phosphate.
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PMC11317131
Active integrase variants recombine the AP and CP resulting in pIII expression and increased phage progeny.
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PMC11607638
The red fluorescent protein sequence pKillerRed was tagged to 5′ end of SKR sequence, to obtain plasmid pKillerRed‐SKR (Genescript, Nanjing, China).
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PMC9429973
Although this might mean that such severity scores can be used to predict severity in SCD patients, further validation in prospective HSCT cohorts is warranted.
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PMC11322866
Lamin B1 is the primary structural component of the nuclear envelope.
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PMC11650848
6Linkage disequilibrium heatmap.
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PMC10565698
D–K. CCK-8 (D and E), EdU (F–H), and colony formation (I–K) assays with HCCLM3 and BEL-7407 cells after knockdown of circUSP10.
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PMC11590005
Furthermore, there is the social desirabili-ty of being accepted in society .
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PMC7342409
The injected volume was 0.1 mL/animal, and the number of cells in normal or drug-resistant strains containing GIST882 was 5×10/animal.
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PMC11699178
The diagnosis and treatment of ovarian cancer have long been a focal point for researchers due to its subtle early symptoms, resulting in many patients being diagnosed at advanced stages, thereby complicating treatment [4–6].
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PMC11687663
Many plant-derived phytoconstituents have been used to treat hepatocellular carcinoma (HCC), including saponins, alkaloids, flavonoids, terpenes, and polysaccharides .
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PMC9429973
DNA sequencing was performed using the PMCC PanHaem hybridisation capture panel of genes recurrently mutated in haematological malignancy.
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PMC11611077
The expression level of prestin per unit surface area, i.e., charge density, of a cell may be obtained as follows: Chargedensity=Qmaxe/Clin0.01 (7) The fluorescent intensities of the constructed clones measured by immunofluorescence experiments showed similar results to those on the charge densities of these clones measured by patch clamping.
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PMC8711270
We also compare their usage against other commonly used host cell lines in each category of biotherapeutics and summarise the factors influencing the choice of host cell lines used.
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PMC9436459
M. yunanensis), M. nigra, M. notabilis, M. wittiorum, S. bonplandii, and S. ilicifoliaMulberrofuran J (1) − 341 M. alba [12–15]; M. australis ; M. lhou ; M. macroura [17–19]; M. mongolica ; M. nigra ; M. wittiorum ; M. yunanensis Mongolicin F (2)− 283 M. macroura ; M. mongolica ; M. wittiorum ; M. yunanensis Albasin A (3)− 217.7 M. alba Morushalunin (4)− 374.4 M. alba var.
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PMC9031474
Around half of the small molecules that have been approved for cancer chemotherapy since 1940 are natural products .
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PMC11360263
They play a pivotal role in driving tumor progression and influencing tumor diversity .
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PMC11765988
Recent evidence suggests that oncological immunostimulant therapies (such as interferon, PDL1 inhibitors, and anti-TNF-α) may be responsible for granuloma formation , especially in patients with hematologic malignancies, such as non-Hodgkin’s lymphoma, chronic myelogenous leukemia, multiple myeloma, essential thrombocytosis, and predominantly Hodgkin’s disease .
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PMC11342785
All TPPP variants were then inserted into a pBH4 vector which contains GFP sequence and His-tag at N-terminal region.
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PMC10158546
ReN cells can also be differentiated as thin 3D cultures embedded within Matrigel matrix. (
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PMC11706491
When cells were grown in rich media (YE5S), we observed a shortening of the cell cycle duration, mainly because the G2 phase was reduced (Fig 1E–1G).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Results: TLR9 activation induced a dichotomous migratory response in CLL patient samples.
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PMC9429973
Results: In a total of 1899 patients, 174 (9%) patients had hMDS.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "In", "a", "total", "of", ...
PMC9429973
P. Kountouris, C. Stephanou, N. Archer, F. Bonifazi, V. Giannuzzi, K. Kuo, A. Maggio, J. Makani, M. D. M. Mañú Pereira, K. Michailidou, S. W. Nkya, O. Nnodu, S. Trompeter, L. Tshilolo, A. Wonkam, B. A. Zilfalil, B. Inusa, M. Kleanthous Molecular Genetics Thalassaemia Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus; Pediatric Hematology-Oncology, Dana-Farber/Boston Children’s Cancer and Blood Disorder Center, Boston, United States of America; Fondazione per la ricerca farmacologica Gianni Benzi onlus, Bari, Italy; Division of Hematology, University of Toronto, Toronto, Canada; Campus of Hematology Franco and Piera Cutino, Azienda Ospedaliera Ospedali Riuniti Villa Sofia, Palermo, Italy; Department of Haematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Translational Research in Child and Adolescent Cancer, Vall d’Hebron Institut de Recerca, Barcelona, Spain; Biostatistics Unit, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus; Hematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar Es Salaam, Tanzania; Department of Haematology & Blood Transfusion, University of Abuja, Abuja, Nigeria; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, United Kingdom; Centre Hospitalier Monkole, Kinshasa, Congo, The Democratic Republic of the; Division of Human Genetics, University of Capetown, Cape Town, South Africa; Universiti Sains Malaysia - Kampus Kesihatan, Kubang Kerian, Malaysia; Paediatric Haematology, Guy’s and St Thomas’ NHS Trust, London, United Kingdom Background: Haemoglobinopathies, including sickle cell disease (SCD) and thalassaemia syndromes, represent the commonest monogenic diseases in the world.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11719944
In patients with T1D, the population of exhausted CD8 T cells is increased compared to that in healthy individuals.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "patients", "with", ...
PMC5833712
e Representative Western blot analysis of PARP1 cleavage in A2780cis cells transfected with non-specific or KDM6B-specific siRNAs after 24 h treatment with 40 μM of cisplatin alone or in combination with 10 nM of KB9520.
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PMC7553912
WT mice were given intraperitoneal injection of GOx (80 mg/kg) once daily for 3 days.
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PMC9429973
The combination of bendamustine + obinutuzumab is approved for pts with relapsed/refractory (R/R) FL.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combination", "of", "bendamustine", "+", "obinu...
PMC11723947
j Percentage of spleen Foxp3 cells among anergic or non-anergic WT and HP1γ KO TCR Vβ6 Tconv 21 days after engraftment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "j", "Percentage", ...
PMC11411004
However, increasing the yield of recombinant proteins in cell culture remains a challenge.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "increasing", "the", "yield", "of", "recombinant", ...
PMC10965680
Genome-wide distribution of F ST (C), the θ π ratio (D), XP-EHH (E), and CLR (F).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591038
In addition to iron chelators, several chemical compounds or proteins exert beneficial effects against AD via the induction or stabilization of HIF-1α.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11742864
Globally 45–69% of patients with lung cancer are reported to develop nutritional deficiencies, which might result in poor responses to therapeutical treatments and poor quality of life for patients.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
N. G. Daver, A. H. Wei, E. M. Stein, D. J. DeAngelo, D. Pathak, Y. Xu, S. Grzesiak, A. Venditti Department of Leukemia, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, United States of America; Department of Clinical Haematology, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York; Dana-Farber Cancer Institute, Boston, United States of America; Novartis Pharmaceuticals AG, Basel, Switzerland; Novartis Pharmaceuticals Corporation, East Hanover, United States of America; Hematology, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy Background: Treatment options for patients with AML who are not candidates for intensive chemotherapy (IC) are limited.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9341513
First, we note that the positioning of the spots is consistent with the translocation.
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PMC10713411
Among these, TRIB3 received the highest score and was selected as the hub gene.
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PMC11354239
The production of cytokines, such as IFN-γ and TNFα, can be considered surrogates of NK cell activation.
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PMC11705862
For CD59 the BRICK 229 (IBGRL research #9409P) antibody was used, 1:2000 in 5% milk in immunowash, with Dako goat-anti-mouse 1:5000 as secondary antibody.
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PMC8592717
As a significant anthocyanin metabolite in dietary polyphenol-rich food, the antioxidative effects of PCA were evident during cancer progression in humans .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", ...
PMC10440586
In cases where P values were equal, we assigned the sample to the subtype with the highest enrichment score.
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PMC11476264
FBXO11, as a member of the SCF (Skp1-Cul1-F-box) ubiquitin ligase complex, exhibits E3 ubiquitin ligase activity and methyltransferase activity .
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PMC9429973
Complete response was defined as the best result, as assessed by the treating physician using the Response Evaluation Criteria in Lymphoma 2017 (RECIL criteria).
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PMC11363012
In particular, we monitored the fluorescence signal as idioblast cells from C. roseus leaves display a characteristic blue fluorescence due to the accumulation of the alkaloid serpentine (4), and we also monitored the presence of colored cells, which accumulated anthocyanins (Figure S5c).
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PMC9966931
In the case of A. niger, the SGI results are not shown in the graph because only (1) and (2) exerted low efficacies, and the other hybrids appeared to be completely ineffective in inhibiting spore germination.
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PMC11622247
In presence of target, intercalation prevents direct contact and the auxiliary dyes serve as light collectors that increase the extinction coefficient of the base surrogates acting as hybridization reporter.
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PMC9370419
Cells from each well were washed with PBS twice, added with 100 µL of PBS and 100 µL of Lytic Reagent, and mixed on an orbital shaker (600 rpm) for 5 min.
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PMC11591038
Based on the report “2023 Alzheimer’s disease facts and figures” , nearly 6.7 million Americans aged 65 years and above are estimated to suffer from AD.
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PMC11612508
Compared to the magnetization of NPs encapsulated in a microsphere, which is about 34.6 emu/g, the saturation magnetization of the IO nanostructure is around 62.4 emu/g.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11566417
b (i) Percentage of scratch closure in a monolayer of bovine fibroblasts cultured in primary and immortalized MDEC CM, p10 and p20 for 48 h (ii) Percent of scratch closure 48-h post-scratch in fibroblasts co-cultured with CM from the four cell line conditions.
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PMC11127909
Our results suggested that EFHD1 binds directly with ANT3, blocking mPTP opening and boosting mitochondrial function.
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PMC11758416
Adjust aliquots of L cells to a concentration of 10,000 L cells (or desired number of L cells per assay well) per 100 μL.e.
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PMC11775197
In 1999, He et al. initially demonstrated that adenomatous polyposis coli (APC) inhibits PPARβ/δ expression by interfering with the β-catenin/Tcf-4 pathway by analyzing whole gene expression profiles.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594588
Increased mitochondrial maturation and differentiation (biogenesis) and oxidative stress in them under the influence of ROS lead to mitochondrial DNA damage and mutations due to external factors (ionizing radiation, radiation) or internal factors (lipid peroxidation, formation of modified DNA bases such as etheno or propano due to interactions of active substances of drugs).
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PMC9429973
no difference in median PFS was observed [RVd-Elo=29 mos.,
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PMC8140214
Effect of D-glucose and/ or quercetin on GR activity in HepG2 cells after 48 (A) and 72 (B) hr treatment.
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PMC11703992
E The drug response of different T subclusters, Additionally, the drug response of different T cell subclusters in GCA revealed that the CD4+ Memory T cells showed the lowest response to DDIT4 inhibitory drugs, while CD4+ /CD8 + Naive T showed the highest, which further indicated the immune suppression of CD4+ Memory T cells (Fig. 7E).
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PMC7762347
The cells were left for 24 h at 37 °C in 5% CO2.
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PMC11747949
CD11bCCR2 and CD11bCD86 surface expression differences in monocytes/macrophages from tumors of mice treated with CCR2 antagonist (yellow with brown circles) versus controls (pink with red circles). (
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PMC11597291
Furthermore, PEG has many desirable attributes, including the availability of various end-functional groups, which provide flexibility in coupling to nanoparticles with diverse chemical structures, the availability in linear or branched forms, and the availability in a large range of molecular weights.
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