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PMC11794847
The JASPAR website indicated that FOXA2 can bind to the GPT2 promotor site.
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PMC11089031
Consistent with the mRNA expression data, the IHC results showed that the expression of ZNF692 was higher in tumor tissues than in paracancerous tissues (Fig. 2C, Table 3).
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PMC6379402
To improve our understanding of the functioning of cancer cells, we propose a novel concept of a bottom-up, data-driven integrated model of the cell, which we call an iCell (stands for an integrated Cell).
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PMC10719213
Because of nuclear-encoded mitochondrial pseudogenes, we developed an approach to ensure specific sequencing of the mitochondrial genome.
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PMC10919056
Low expression of GJA5 and GJB1 is associated with poor patient prognosis.
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PMC11395280
CCL198-83 significantly blocked the peak Ca response in the presence of CCL19 (Figure 2A,B) without affecting the mobilization of Ca in the presence of CCL21 (Figure 2D,E).
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PMC9000591
The present findings are expected to contribute to the development of blood cancer therapy.
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PMC9429973
BM examination was consistent with a diagnosis of AML with monocytic differentiation, while cutaneous biopsy showed a dermic infiltration of leukemic cells.
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PMC9960565
After the conjugation of cisplatin, the characteristic band around 280–300 nm from the interior tertiary amines of the PAMAM dendrimer (Figure S28) did not significantly shift, suggesting that cisplatin conjugation has been achieved only at the surface of the dendrimer.
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PMC7171147
N = 2.
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PMC11574029
The migration ability of the cells was evaluated by measuring changes in the wounded area.
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PMC11285179
represent p < 0.05, p < 0.01 and p < 0.001, respectively.
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PMC10719213
The slower proliferating CCRF-CEM cell line showed greater sensitivity to cladribine already at lower effective concentrations (10 nM), which resemble the clinical plasma concentrations .
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PMC10587429
Interestingly, when we administered the same dose (100 μg/animal) to the tumor-bearing humanized NSG-SGM3 mice, the animals died after a single injection.
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PMC7338939
A total of 1 × 10 cells were washed with PBS and fixed with paraformaldehyde 4%, permed with Triton X-100 (2%), and blocked with bovine serum albumin (BSA) 10% according to the Azimian-Zavareh et al. method (31).
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PMC11731161
To further elucidate the degradation pathway of XPO1 protein, we treated NCI-H929 cells with SEL in combination with either the ubiquitin proteasome inhibitors MG-132 or the autophagy/lysosome inhibitors Leupeptin (LEU).
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PMC9429973
Interestingly, lower response rates of IGM-2323 were observed at the highest dose levels of 600 mg and 1000 mg.
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PMC11705862
The staining showed a moderate degree of colocalization between GFAP and IRIS-1 or IRIS-2 in astrocytes (indicated with arrows).
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PMC11532793
This scenario often occurs when annotated transcripts differ by a single exon and no sequence read is compatible with that particular exon.
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PMC11627398
Septic shock was diagnosed according to the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis 3.0) criteria .
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PMC11615743
In addition, we observed more products as the concentration ratio of the trigger to HCR hairpins increased (Figure 2A).
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PMC4270159
The actual power obtained is listed.
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PMC11543885
This study provided additional insights into the NLRP3 proximity networks in a more appropriate cellular system.
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PMC11762280
B UVB skin damage of Krt14-Mlkl mice and Krt14-Mlkl mice was evaluated by scores (n = 5).
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PMC11739504
Further investigation is needed to elucidate the possible relationship between Kat2b and other primary ciliary proteins.
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PMC10745221
The images on the top show Coomassie-stained SDS-PAGE gels, and the images on the bottom show films exposed for fluorography for 63 days.
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PMC9429973
The omission of a dose of DOAC due to unavailability is a systemic supply issue that needs to be addressed within the hospital.
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PMC9429973
Treatment with 1 and 10 uM Ruxolitinib impairs NKAES cell proliferation, while at low doses of Ruxolitinib NKAES cells proliferate until day 14.
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PMC9429973
Neutralizing antibodies (NAbs) against SARS-CoV-2 were measured using FDA-approved methods.
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PMC10538569
Cell-cell transfer of GPI-anchored proteins has been shown in vivo, such as transfer of complement restriction factors CD55 and CD59 from erythrocytes to the vascular epithelium and from male genital tract epithelium to spermatozoa (45).
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PMC10440586
Samples are divided by IDH mutation status and then arranged by CD99 expression level.
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PMC9429973
Unfortunately, high LDH values ​​at the first relapse had a negative impact on PFS beyond the treatment used.
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PMC11745823
Furthermore, the examination of the association between RIT1 mRNA expression levels as well as clinicopathological features in a cohort of 98 patients with glioma (Table S1) revealed a significant interplay with tumour size (p < 0.001), Karnofsky Performance Status (KPS) (p = 0.012), WHO tumour stage (p < 0.001), and tumour recurrence (p = 0.025).
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PMC10605143
Cells were washed twice with PBS, suspended in the Flow Cytometry Buffer and incubated with APC-conjugated antibody against EPCAM (BioLegend, San Diego, CA, USA, 5 µL/1 × 10 cells) and PE-conjugated antibody against ITGA6 (BioLegend, 5 µL/1 × 10 cells) or PE-conjugated antibody against CD24 (clone ML5, 311106, BioLegend, 5 µL/1 × 10 cells) and FITC-conjugated antibody against CD44 (clone BJI18, 338804, BioLegend, 5 µL/1 × 10 cells) for 30 min at room temperature in the dark.
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PMC11472639
Fig. 2 Representative gating strategies for plasma cells and B-cells.
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PMC9219615
Interestingly, the SCI for hematopoietic cells averaged 13.82; thus, in vitro specificity of Tpz-1 toward blood cancers exists.
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PMC11538390
In non-Finnish European populations, the prevalence of CL/P is higher than that of CP (0.80 per 1000 births versus 0.55 per 1000 births, respectively), as reported by EUROCAT for the years 1980–2020.
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PMC10048572
The frequency of LOH occurrence in subclones for certain STR loci differs, and, apparently, is a pattern specific for this particular acute T-cell leukemia cell line (Figure 3 and Figure 4).
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PMC11591052
In the present study, we observed the 20E-dependent up-regulation of both catabolism and anabolism, coupling energy-producing and biosynthetic metabolic processes in mouse myoblasts and fibroblasts.
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PMC9429973
DHX9 dysfunction promotes tumorigenesis in several solid cancers.
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PMC10882807
After collected, the purified RNA was extracted and detected by qRT-PCR.
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PMC11049548
As discussed above, the main differences at the levels of the endo-metabolome could be restricted to the metabolites related to the mechanisms of acquired resistance upon drug treatment.
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PMC6190245
Then, they were exposed to 2 Gy γ-rays and incubated for 66 hr.
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PMC11678130
For instance, Suruli and colleagues revealed that the combination of naringenin, a bioflavonoid found in grapes and citrus fruits, with 5-FU suppresses A375 CM cells’ growth and proliferation .
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PMC11481779
We take the residual heatmap and apply Gaussian noise multiple times - up to T. Then, we take such a noised image and use a denoising U-Net network.
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PMC11463018
To reduce oversized molecular weight of new merged structure and improve ligand efficiency for both targets, we also removed the thiomorpholine group on 5-phenyl-triazolopyridine of Filgotinib as exemplified by compound 10 (JAK1 IC50 = 70 nM; JAK2 IC50 = 138 nM), although such a change might lead to a decreased activity for JAK.
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PMC6182045
Therefore, we assembled a panel of clade C envelope proteins to identify a clade C gp120 able to bind multiple families of bNAbs.
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PMC11680562
These changes are attributed to temperature-induced degradation and phase separation of the gel components.
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PMC9429973
The BCL2-specific inhibitor venetoclax has proven efficacy in AML treatment particularly in combination with hypomethylating agents (HMA) or low-dose cytarabine.
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PMC11676674
Three different dilutions in LC-MS grade water (1:10, 1:50, and 1:100, v/v) were prepared from methanolic extracts of C. monspeliensis leaf powder and then filtered through 0.22 mm Minisart filters (Sartorius-Stedim Biotech, Gottingen, Germany) before the LC-HRMS analysis.
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PMC11300639
CancerSEA web tool analysis revealed that RNF26 was positively associated with the biological processes of epithelial–mesenchymal transition (EMT), invasion, stemness, proliferation and angiogenesis in ccRCC cells (Fig. 3b).
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PMC11754094
The infected cells were selected with puromycin and transfected with Cas9 RNP complex targeting the puromycin resistance gene using electroporation.
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PMC11678368
These limitations have driven ongoing research into new platinum(II) and palladium(II) complexes with improved therapeutic profiles and reduced toxicity .
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PMC11591038
HIF-1 consists of an alpha subunit (HIF-1α) that senses the low-oxygen tension for its stabilization and a beta subunit (HIF-1β) that is constitutively expressed .
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PMC7433824
As high glycolysis is necessary for tumor growth and survival, a decrease in PKM/PKM with P4 may be an important mechanism of growth suppression.
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PMC9739791
For hydroxylated Pt(IV) prodrugs 18–22, 8 min of irradiation were required for complete reduction.
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PMC11748363
The reaction mixture was washed with distilled water (2–3 times, 30 mL).
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PMC11638255
Heatmap of log2FC in expression for genes associated with (c) N1 anti-tumorigenic or (d) N2 pro-tumorigenic neutrophil phenotypes from control vs. TEPA-treated Th-MYCN tumors within the neutrophils cluster.
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PMC9429973
Event Free Survival (EFS) was defined as time from the 1st day of R-CHOP therapy until relapse or progression, unplanned next treatment, or death as a result of any cause.
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PMC9429973
Lastly, we confirmed that they had a biological effect of decreasing the levels of hnRNP K downstream pathways as well as inducing changes in viability dose-response curves, using Multiple Myeloma cells (AMO1 and L363) genetically modified with CRISPR/SAM technology to overexpress hnRNP K. Likewise, we investigated the absence of such biological effect in hnRNP K-Knock Out (KO) AMO1 and L363 cells, obtained by CRISPR-Cas9.
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PMC11295144
Neuronal cultures and co-cultures with HEK293 cells were maintained in Neurobasal medium (21103–049, Gibco) containing B27 supplement (17504–044, Gibco), glutamine (2 mM, 25030–024, Gibco), penicillin (50 units/mL, 15070–63, Gibco), streptomycin (50 g/mL, 15070–063, Gibco), and glucose (6 mM, G8769, Sigma).
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PMC11320834
The threshold for significance was defined as p ≤ 0.05. *
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PMC7887261
Knockdown efficiency was quantified by RT-qPCR and shown in Supplementary Fig. 6.
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PMC11429241
As previously mentioned, no visible differences were observed regarding the scaffold material (Figure 9).
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PMC11476004
Nowak and Madej also noted very similar rates of tumour occurrence in male and female dogs (49% and 51%, respectively).
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PMC11509224
The unusual diterpene hymerhabdrin A (139, Figure 13) was isolated from an intertidal marine sponge Hymerhabdia sp. .
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PMC11470999
To investigate how PF modulate CIP2A, we firstly examined the effect of PF on CIP2A protein levels.
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PMC11684297
The magnificent biocompatibility in vitro encouraged us to explore the anticancer and anti-amyloid activities.
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PMC9874064
The results showed that the apoptosis rate of BEL-7404DPP cells treated with NP-Pt-USP1i (16.26 ​± ​1.8%) was 5.7 times that of cells treated with PBS (2.85 ​± ​0.99%) (Fig. 3C and D).
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PMC11286266
The genotype–phenotype relationship suggested by the screen was also observed upon targeting FURIN in ATF6α/IRE1 dual reporter cells, as both pools of targeted cells and an individual clone had diminished responsiveness of BiP:sfGFP to ER stress (Figure 1—figure supplement 4A, left and middle panels).
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PMC9429973
All cases were confirmed by biopsy.
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PMC5839394
Peptide mixtures were desalted by μZip-TipC18 (Millipore, MA)).
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PMC11402217
Fluro-4 AM detection of Ca dynamics in OS cells treated with XD23 in 12h. (
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PMC11731614
Fractions 2 and 3 were enriched with the EV-associated cargo markers Alix, Tsg101, and Syntenin-1 as well as the transmembrane tetraspanins CD63 and CD81 (Arya et al., 2024, Mathieu et al., 2019, Gurung et al., 2021, Kalluri and LeBleu, 2020).
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PMC11787651
Histones were extracted from nuclei by incubation in H2SO4.
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PMC10114490
Dendrogram depicts a cluster composed of diHLC-T together with PHH (Fig. 6A).
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PMC11285179
To further confirm our study, we examined the expression of CCL28 under hypoxia conditions in the nine cell lines.
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PMC11536589
Scatter plot shows the tumor weights (means ± SEM). (
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PMC8481254
Scale bars: 500 μm.
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PMC11740399
T24 cells and 5637 cells were treated with 3025@ML, OXA, or the com by reducing PKM2 and FASN bination to verify 3025@ML enhanced anti-tumor activity of OXA by CCK8 analysis (A and B) and trypan blue staining (C and D).
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PMC11750712
c, PFS based on overall response (Lugano classification).
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PMC9621239
C-H) Levels of DNA replication were examined by the EdU incorporation assays in HCC cells.
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PMC11482552
In particular, the inclusion of a reliable sample adequacy assessment would help to reduce the potential risk of false-negative results due to inadequate sample collection, particularly in cervical screening programs based on self-collected samples, as clearly pointed out in a recent report .
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PMC9429973
Currently, 3 iron chelators are approved for clinical use: deferoxamine administered parenterally (DFO), oral deferiprone (DFP), and oral deferasirox (DFX).
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PMC9429973
TP53 mutations were reported in 14/48 (29.2%) pts in C2 and 21/40 (52.5%) pts in C3.
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PMC10975211
For buforins, several bioconjugation strategies have been explored, including peptide conjugation with nanoparticles, liposomes, and polymeric carriers.
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PMC11528603
Importantly, the transcription assessment of apoptotic and proliferative genes suggested that SA-EA might suppress the growth of HL60 cells and induce p21-dependent apoptotic pathway.
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PMC4395774
These results demonstrate that the progenitor cell reconstitution of prf mice with perforin expressing LVs leads to a recovery of CD8 lymphoblast function in vitro, both in perforin-mediated killing and regulation of IFN-γ secretion.
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PMC9429973
KitM pretreated samples also revealed improved blast lysis after MLC.
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PMC11711063
HISAT2 was used for alignment using the human (Homo sapiens) (b37): hg19 genome gene expression was quantified using the Featurecounts tool.
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PMC9429973
Related donor trasplant with RIC regimen seems the best option dice less toxicity although comparative studies are necessary to confirm these results.
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PMC11694346
This could also be attributed to the nucleophilic properties of H2S, which allows it to interact with the DNBS moiety of BT-DNBS, leading to fluorescence activation.
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PMC5308810
However, all these approaches only exhibit modest anticancer effects, presumably because the drugs only block the activities of SDF-1/CXCR4 axis instead of eliminating the cancer cells.
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PMC10887351
After an ischemic injury, to preserve cardiac output, it has been observed an increased sympathetic activity and increased release of CA that stimulated the β-AR-mediated inotropic capacity.
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PMC11707832
Genetic analysis identified the mutation c.2245C>T, p. (Arg749Trp) in MAN2B1 in this case.
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PMC11787651
A, number of peptides identified in each control and TGF-β treated biological replicate by injection of either 200 ng or 1 μg on the Orbitrap and 200 ng on the ZenoTOF.
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PMC11194678
Statistics data were collected from triplicate experiments.
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PMC8735881
Viral titers were determined in TZM-bl cells by a 50% tissue culture infectious dose (TCID50) assay.
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PMC8143558
These are the following (the emboldened species are also cultivated): Albizia versicolor Welw.
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PMC11519077
Recent researches on the human microbiota have revealed that the intestinal bacterial community plays a significant role in the pathogenesis of both systemic and intestinal disorders, including CD .
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