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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
Also in this group 2 nonsense mutations, 1 splicing mutation, and 1 deletion were observed.
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PMC11525028
Combination of paliperidone and AG-401 offered a favorable antitumor effect with slower tumor growth than single-agent treatment (Figures 7G and S6D), which resulted in extended survival of mice (Figures 7H and S6E), and there were no significant changes in body weight of combined treatment group (Figures 7I and S6F).
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PMC9509578
Their results showed sustained drug release and miRNA-205-mediated suppression of tumor growth, activation of apoptosis-mediated signaling pathways and reversal of drug resistance .
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PMC10996034
One-way ANOVA and least significant difference tests were used for the statistical analysis and were performed using SPSS (version 26.0; IBM Corp.); visualization was carried out using GraphPad Prism (version 5; Dotmatics).
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PMC11615218
For instance, interleukin-7 (IL-7) and IL-21 induce TSCM differentiation, and together with IL-15, they promote the maintenance and expansion of TSCM.
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PMC11742864
The patients receiving ONS-EPA increased lean body mass by 1.65 kg, while those in the control group reduced by 2.06 kg (p < 0.01).
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PMC1977768
It is suggested that acquired drug resistance caused by deficient transport mechanisms may be partially or wholly overcome by targeting the drug to a readily-internalised cell surface antigen.
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PMC11434983
After vortexing for 1 min at room temperature, the mixture was centrifuged at 5000 rpm for 5 min.
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PMC11777207
In Pdl1 mice, we observed similar amounts of PD-L1 and CD80 on cDC1s (fig. S9).
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PMC11763764
The patient survival dataset was available from https://v22.proteinatlas.org/. Kaplan–Meier analysis was used for the survival analysis.
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PMC11742670
Cell LinesNumber of the generated descriptorsNumber of the selected descriptors using FRS algorithmA-5494419A-3754429A-4314429 Summary of Generated and selected descriptors for each cancer cell line.
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PMC11473843
Percentage of proliferation inhibition of A549, A427 and H460 cell lines treated with increasing doses of XMD8-92 or Seliciclib or in combination (top) 48 h after treatment and representative crystal violet-stained cells 72 h after drug treatment (bottom).
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PMC10761571
The physical and chemical features of the nanoparticles were investigated by FT-IR, XRD, zeta potential, DLS, EDS mapping, VSM, and electron microscope imaging.
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PMC11612508
The plant contains active phytochemicals such as saponins, flavonoid glycosides, phenolic compounds, and multifunctional proteins.
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PMC9429973
The accuracy of PET/CT over CT scanning (with a sensitivity and specificity higher than 90%) has been compared in several works in order to assess the extent of the disease, leading to modifying the staging in 15%-40% of cases with an impact on the therapeutic strategy in approximately 15%-20% of cases.
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PMC11345828
s, 0.5H), 6.72 (s, 1H), 6.69 (s, 1H), 6.60–6.58 (m, 1H), 4.61–4.57 (m, 0.4H), 4.32–4.26 (m, 0.6H), 4.24–4.12 (m, 1H), 4.10 (s, 1H), 3.99 (s, 2H), 3.97–3.95 (m, 2H), 3.78 (d, J = 2.8 Hz, 2H), 3.75 (s, 1H), 3.69–3.59 (m, 1H), 3.25–3.19 (m, 3H), 3.17 (s, 1H), 2.34 (s, 1.8H), 2.32 (s, 1.2H), 2.24 (s, 6H), 2.12–2.11 (m, 1H), 2.07–1.97 (m, 5H), 1.92–1.89 (m, 1H), 1.16 (d, J = 6.0 Hz, 2H), 1.07–1.05 (m, 1H), mixture of rotamers.
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PMC9429973
Patients urgently referred by GP for suspected cancer fell by 50% nationally during the first lockdown.
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PMC11462673
D CRISPR screen data indicated the dependence of T-ALL cell line Jurkat on LDB1.
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PMC11443022
Notably, the patient had a history of cryptorchidism and hypospadias.
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PMC6267596
Images were captured every 20 minutes over a 48-hour period in order to visualize reductive cell division.
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PMC11247842
We conducted meta-analyses of eight and fourteen GWAS on CM and SCS, respectively, using 30,689 and 119,438 animals from six dairy cattle breeds.
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PMC11049294
Although AGAL activity can be measured in plasma, dried blood spots, and in isolated white blood cells, the leukocyte enzyme activity measurement is the gold standard .
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PMC11507371
Briefly, 10 µL of metmyoglobin and 150 µL of chromogen were added to each sample containing 10 µg protein and a Trolox standard ranging from 0 to 0.495 mM. The reaction was initiated with the addition of 40 µL of hydrogen peroxide to each well.
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PMC9985266
In this study, combined with the previous discussion, we found that IL-27 can promote autophagy in MRC-5 cells and reduce the expression of TGF-β1-induced fibrosis markers.
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PMC9596868
B–D) Colonies were quantified using ImageJ software as colony number relative to control in PA-1, A2780 and HCT116 cells respectively.
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PMC9429973
CD3+ cells were collected from PB samples and total RNA was isolated.
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PMC9786247
The possibility of genuine replication of C. burnetii in bovine mammary gland tissue is consistent with reports that the bulk tank milk of dairy herds in the US and Europe contains substantial numbers of C. burnetii, e.g., more than 10 bacteria/mL .
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PMC11782508
They are small in size, exhibit high specificity and affinity for inhibiting various cancer cell lines, readily penetrate cell membranes, and exhibit minimal drug-drug interactions.
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PMC10887351
The C-terminus is the region with the lowest homology and is characterized by the lack of phosphorylation sites, which are involved in the agonist-dependent desensitization of the β1- and β2-ARs isoforms .
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PMC11092382
It may enhance antitumor immunity when used alone or in combination with other therapeutics.
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PMC11088135
A MTT assay was conducted to assess the cell viability of U251 cells.
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PMC11775197
↓ indicates inhibition and ↑ indicates increase.
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PMC8345486
The percentage of necrotic cells (PI+) and cells in late apoptosis (PI+/annexin V+) increased twofold in “+25 cells” compared to that of the cisplatin and carboplatin-treated control, while the percentage of early apoptosis cells remained unchanged (Figure 9A,B).
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PMC9583612
We do not attempt a root-cause analysis for the events presented in Figure 5, as current CEMS solutions do not provide reliable localization capabilities.
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PMC9429973
A. Guerra, P. Demsko, S. Sinha, P. McVeigh, C. Castruccio Castracani, L. Breda, C. Casu, S. Guo, S. Rivella Pediatrics, Children’s Hospital of Philadelphia; Pediatrics, University of Pennsylvania, Perelman School of Medicine, Philadelphia; Pediatrics, Ionis Pharmaceuticals, Inc., Carlsbad, United States of America Background: The hallmarks of β-thalassemia (BT) include ineffective erythropoiesis (IE), splenomegaly and iron overload (IO).
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PMC11429241
As a control, we used scaffold-free 3D structures of both ovarian cancer cell lines.
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PMC9429973
The demographic and clinical characteristics, including gender ratio, age, paraprotein isotype, ISS, R-ISS, were comparable among different MT regimen groups either receiving ASCT or not at baseline (Table 1).
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PMC10198699
In a recent article, Thaldar and Shozi present the first comprehensive analysis of South African law on the topic and conclude that HBM in the research context is indeed susceptible of ownership.
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PMC8481254
G, H Cell proliferation and colony-formation capacity were measured with CCK-8 cytotoxicity tests (G) and soft agar colony-formation assays (H), respectively, in Bel-7402 and Bel-7404 cells subjected to different treatments as indicated.
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PMC11448304
Finally, the peptides were desalted by Strata X SPE column.
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PMC9429973
Summary/Conclusion: Our work suggests that impaired erythroid differentiation of AEL cells involves aberrant GATA1 protein complexes.
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PMC11127909
CATR, a conformational inhibitor of ANT3, increases chemosensitivity in EFHD1-positive cells when used in combination with cisplatin.
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PMC11731614
Isolated DiR-labeled EVs from fractions 2–3 were then used for downstream applications with a negative DiR control, which was DiR-added to concentrated EV-depleted unconditioned medium passed through the column with the same fractions collected for experiments.
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PMC6901583
The conditioned medium from the cells transfected with BRD4 caused the monocytes to be activated into macrophages, as seen by the CD206-high/HLA-DR-low phenotype, which was not observed in cells treated with the conditioned medium from controls (Fig. 7b).
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PMC11766174
qPCR was carried out using the QuantStudio 12K Flex system (ThermoFisher Scientific, Carlsbad, CA, USA).
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PMC10988555
First, the levels of apoptosis, a type of programmed cell death, and necrosis were determined by flow cytometry using the Annexin V – Alexa fluor 488/PI double staining after 48 h of exposure of A2780 cells to the IC50 of each complex 2–4 (Figure 8).
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PMC9429973
Six pts had HGBL TH, 26 pts - c-MYC/BCL2 HGBL DH, 16 pts - c-MYC/BCL6 HGBL DH and 51 pts - HGBL NOS.
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PMC8633974
We next sought out the mechanism of TatDE LNPs trafficking into the cells using confocal laser scanning microscopy.
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PMC11704135
These modifications may have hindered the compound's ability to exert its antimicrobial effects effectively.
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PMC10667689
Furthermore, HL-60 is known to be less glycolytic compared to other AML cell lines, including THP-1 (38); the lower expression of TIM-3 on the M-3 subtype of AML may be the cause.
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PMC5311252
Both RB1 and TP53 are key regulators of the senescence program that includes and relies on the activation of several different CDK inhibitors including CDKN1A.
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PMC9429973
Image: Summary/Conclusion: Plasma with high titers of neutralizing SARS-COV2 antibodies can clear persistent infection in patients with hematological malignancies and immunocompromised patients.
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PMC8524093
On the other hand, excessive IL-1β production as well as IL-6 and TNF-α, which are pyretic cytokines, result in an exacerbated pro-inflammatory response that shifts the antiviral response to a robust inflammatory disease.
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PMC9429973
Image: Summary/Conclusion: In this post-hoc analysis, response rates were similar between subgroups of patients with prior off-label rituximab treatment versus rituximab-naïve patients.
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PMC11144200
n = 3, **P < 0.01, ***P < 0.001, ****P < 0.0001.
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PMC11674834
A significant difference between UV5/1A2/NAT1*4 and UV5/1A2/NAT1*14B CHO cells was not observed (p > 0.05) but both UV5/1A2/NAT1*4 and UV5/1A2/NAT1*14B cells had significantly higher DNA damage compared to UV5 and UV5/1A2 cells (p < 0.05 for UV5, p < 0.001 and p < 0.01 for UV5/1A2) (Figure 4).
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PMC9429973
But they lost this response pre-ASCT and they relapsed in 5 and 6 month after ASCT respectively.
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PMC4443654
Among enrichments of a large number of factors observed at different boundaries in different cell types, CTCF and YY1 were found consistently and may cooperate to establish domain boundaries.
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PMC11367146
Fig. 14 Effect of VTE on changes in phosphorylation of (A) ERK2 (B) p38 (C) JNK and (D) STAT3 in IL-1β stimulated SW982 cell by ELISA test.
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PMC9429973
Results: 60 patients (38%) with AML (excluding APL) and confirmed COVID19 received anti-tumor treatment.
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PMC9429973
The methods of descriptive and analytical statistics were used.
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PMC9429973
The incidence of composite CR/CRi was 70.5% in the frontline setting, with median duration of response (DoR) of 8.3 months and overall survival (OS) of 7.1 months.
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PMC8143558
Saponins have the same chemical structure as soaps and detergents, equally consisting of hydrophilic heads and hydrophobic tails.
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PMC9429973
Results: TCL cell lines treated with tolinapant, decitabine or both led to depletion of cIAP1 and DNMT1 in TCL cell lines, demonstrating target engagement of both agents.
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PMC11607638
But no difference was found among the three SK injection groups (Figure 3B).
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PMC11637284
Beads were washed in cell lysis buffer supplemented with 40 mM imidazole, and cell lysis buffer supplemented with 200 mM imidazole was used for elution of the fusion protein.
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PMC10142392
The development of biodegradable ocular implants capable of providing prolonged release of a corticosteroid drug, such as TA, for at least 6 months is a major advance in the fight against posterior segment eye diseases such as diabetic retinopathy.
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PMC8873393
Cells were then counterstained and mounted with mounting medium containing DAPI.
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PMC11173119
Cultivation of the obtained cells was carried out on a mitotically inactivated mouse embryonic fibroblast (MEF) substrate.
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PMC8540692
This finding shows a cell line-dependent manner of RASSF1A expression regulation by CCM and NaBu, and indicates that this issue should be further analyzed.
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PMC11583690
The weight of MSN@DTX was 8.31 mg and the weight of BPMO@DTX was 8.18 mg.
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PMC6889484
For detection of A3F, the rabbit polyclonal anti-human APOBEC3F (A3F) antibody (C18) was used at a dilution of 1:500, obtained through the NIH AIDS Reagent Program, Division of AIDS, NIAID (from Dr. Michael H. Malim; catalog #11474).
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PMC11594806
Consequently, the A2AR signaling cascade directly inhibits TCR activation, fostering an immunosuppressive environment.
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PMC11803918
The surface expression of functional proteins was then analyzed under the NovoCyte Quanteon (Agilent).
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PMC11768927
This review outlines key preclinical studies of VSV oncolysis and highlights recent advancements in understanding the mechanisms underlying VSV resistance in cancer virotherapy.
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PMC9672323
Similarly, recent data have suggested that glucocorticoids can influence T-cells proliferation and their response by modulating the expression of downstream molecules involved in TCR signaling.
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PMC7887261
Overexpression plasmids transfections were performed using GenJet In Vitro DNA Transfection Reagent Ver.
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PMC7504302
More importantly, the BNC autochthonous tumors responded to and developed resistance against frontline chemotherapy agents with similar dynamics in human tumors.
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PMC11569208
Representative fluorescent images were taken 24hpi. (
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PMC7039683
Barchart showing GO enrichment analysis for two clusters of GFP-negative specific NFRs.
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PMC11763126
D Western blot analysis of PCNA after treatment with Scr or CBDP1.
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PMC11769516
The presented substances require further pharmacokinetic and pharmacodynamic studies.
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PMC11700340
Two hundred microliters of maintenance media were injected into each control well, and the exposure times varied between twenty-four and seventy-two hours.
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PMC9429973
Among the 78 evaluable pts as per IRRC, ORR was 46.2% (95% CI: 34.8%, 57.8%); 29 (37.2%) pts achieved CR; median DoR was not reached (NR); 12-mo DoR rate was 86%.
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PMC10545062
Most notably, these refinements decreased crystalloid utilization without adversely impacting the resuscitation endpoints.
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PMC11593713
We observed that respiratory viral infection more significantly affected non-enzymatic oxidative stress markers in a lung adenocarcinoma model (A549 cells), while human lung fibroblasts (MRC-5 cell line) presented changes in enzymatic and non-enzymatic oxidative stress markers.
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PMC11792766
Differences were considered to be statistically significant when *p < 0.05; **p < 0.01; ***p < 0.001.
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PMC11641630
As mentioned, the integrity of the extracellular matrix is essential for the maintenance of epithelial cells, and during cell invasiveness processes resulting from EMT, there is an increase in the production of certain MMPs .
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PMC11064533
Adhesion also facilitates the deployment of virulence factors that may include the transfer of effector proteins into host enterocytes through type III secretion systems.
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PMC9429973
Recently, FLAG-IDA + VEN was shown to be an effective regimen in AML inducing high rates of MRD negative CR in both ND-AML and R/R AML allowing patients to be successfully bridged to allogenic stem cell transplantation (allo-SCT) (DiNardo 2021).
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PMC11802855
We then investigated the association between CXCL7 expression levels and the number of osteolytic lesions in patients.
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PMC11021472
CircZDHHC11 knockdown inhibits Burkitt lymphoma cell growth.
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PMC3675084
Bcl-2 family members usually substitute for each other, for example, cells expressing low Bcl-2 levels express high levels of Bcl-XL .
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PMC9429973
sVCAM-1 was higher in CD49d+ vs CD49d- CLL (p<0.0001); among CD49d+ cases, sVCAM-1 was lower in HUTS21+ (i.e. VLA-4 activated) cases (p=0.0096), suggesting ligand sequestration by activated surface VLA-4.
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PMC11678130
The images were taken at 20× magnification on the Lionheart FX microscope, and processed in Gen5 version 3.14.
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PMC6182045
MGAT1 CHO expressed gp120 was purified using an anion exchange chromatography column (QFF), followed by a size exclusion chromatography (bottom row).
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PMC10204952
Addition of AD-CM and CAA-CM brought nucleic alteration down to 34.8% (p < 0.05) and 29.8% (p < 0.05), respectively.
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PMC11522251
Recent research has shown that the HOX gene has a strong impact on the development, invasion, and metastasis of many cancers, such as colorectal, prostate, lung, breast, gastric, renal cancers, etc. [
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PMC11727638
FITC-labeled gela-Ph was used instead of gela-Ph for structural analysis of the Cell Domes.
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PMC9429973
The greatest increase is observed for BCR/ABL1-negative chronic myeloid neoplasms.
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