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OTAR3088
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BioData-CellLine_annotated

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PMC11680578
β-actin and PPAR-α were used as housekeeping genes.
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PMC11786600
Images of wound healing over time for different dressing treatments. (
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PMC9429973
In unweighted analysis of avapritinib versus midostaurin, mean follow-up durations were 17.9 and 27.9 months, respectively, during which 34 (19%) avapritinib patients and 56 (60%) midostaurin patients died.
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PMC11699178
DEGs were identified from the RNA-Seq dataset using the "edgeR" package in R software, with |logFC|> 2 and P.adjust < 0.05 as the screening criteria.
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PMC11411131
Cos-7 cells expressing FLAG-TrxR1-HA were treated with 6 µM MeHg for 24 h in the presence or absence of 50 µg/ml cycloheximide (Chx), a protein synthesis inhibitor.
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PMC11659734
The added value of the present project was the comparison between the results obtained in metabolically competent human cells (HepG2) and in human peripheral blood lymphocytes grown in the presence of exogenous metabolic activation.
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PMC11758416
Determine number of T cells in each condition using a hemocytometer.
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PMC5600151
The studies discussed in this section are summarized and presented in Table 4.
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PMC9429973
We additionally evaluated T cell activation by measuring CD25 expression.
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PMC11742047
HL-60 and K-562 cell lines were seeded at 1 × 10 cells/well in 96-well plates (Euroclone, Italy).
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PMC11464982
Abbreviations: +, uncertainty with potential to cause overestimation of exposure; –, uncertainty with potential to cause underestimation of exposure; TOS, total organic solids.
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PMC11092382
The therapeutic efficacy of this treatment for acute pharyngitis may be mediated through the PI3K-AKT, NF-κB, and Toll-like receptor signaling pathways (Pang et al., 2023).
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PMC11756514
Unmixing of the spectral flow data was performed using FITC-labelled bacteria and BV421-FC beads, as described above.
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PMC8193813
Its response time is reported as 5s.
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PMC8357004
The first column of each group belongs to the untreated control group.
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PMC6114978
Herein, utilizing an unbiased approach with clinical samples, we showed in sarcomas that the Hippo kinases can be primarily dysregulated by a variety of mechanisms resulting in their loss of expression (Figure 7A, 7B).
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PMC11719944
When necessary, we conducted a stratified analysis based on prolactin levels, categorizing them into normoprolactinemic and hyperprolactinemic groups.
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PMC11468365
Each row represents a fold in a fivefold cross-validation, with 5 rows in total.
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PMC6222635
The hydrogen signal 4.03 should be attributed to the C2 hydrogen of mannose, whereas 4.69 should be attributed to the anomer hydrogen of mannose.
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PMC11512230
Moreover, promising data have been obtained on the application of the virion and virus-like particles of plant viruses as anticancer agents .
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PMC11453018
Etoposide and topotecan, both topoisomerase inhibitors, are used in the treatment of various cancers, including ES, but their use can also lead to serious side effects such as secondary leukemias and myelosuppression .
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PMC11281366
We found that the infected cell population displayed important changes in the cellular transcriptomes and miRNA expression profiles in relation to the uninfected population.
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PMC10674574
However, both Caco-2 cell lines were considered models for screening healthy food components and drugs that affect α-defensin 5 secretion .
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PMC11023271
Lysophosphatidic acid (#L7260), Lysophosphatidylcholine (#L1881), Propidium Iodide (#P4170), and Centrifugal Filter Units (#UFC501008, #UFC505008, # UFC510008) were from Sigma.
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PMC9429973
It is categorized by disease duration from diagnosis: newly diagnosed (ndITP; ≤3 months [mo]), persistent (pITP; 3-12 mo), and chronic (cITP; >12 mo).
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PMC9429973
Patients with non-transfusion dependent beta-thalassemia (NTDT) do not require regular, lifelong RBC transfusions for survival but may need occasional transfusions.
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PMC11258145
These results were recalculated and expressed as percentage changes.
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PMC10079526
Consistently, we observed an increase in SMC6 foci 4 h post treatment with TAK981 and 5-Aza-2’ (Fig. 3F).
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PMC9429973
The patient is still being followed up with HU 2X1 and phlebotomy without any problem.
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PMC11521786
GraphPad Prism 7.0 software was used for statistical analysis.
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PMC9878278
Together, these data suggest that BMP6 signaling is suppressed in SC at later stages of ZIKV infection and is one of the modulators of anti-ZIKV response in this cell type.
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PMC4277423
Without exception, all our attempts yielded negative results, i.e. no CCR5 gene disruption could be detected by T7 endonuclease I assay, although all these constructs effectively disrupt CCR5 gene in human T cell lines and decent transduction efficency of these constructs into the primary T cells was obtained and Cas9 RNA transcripts were detected by real-time PCR (Wang et al. data not shown).
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PMC11518702
In Raji cells, BCR ligation enhanced HGAL’s co-IP with SYK while decreasing the co-IP of GRB2 and SYK (8).
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PMC9105697
Additional point mutations with a frequency of >5% have been described in SS in several tumor-promoting genes, e.g., TP53 .
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PMC9424261
G The interaction of GSS and MDM2 in tumors were detected by co-IP experiments.
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PMC11269933
The Lipofectamine 3000 (Invitrogen, USA) was used to transfect these plasmids into HeLa cells (Procell Life Science & Technology, China).
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PMC11332076
Our results may have broader implications beyond glaucoma, expanding to other CNS injuries and diseases.
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PMC10926885
The functional experiments described above fill a gap in the study of the role of NDE1 in cancer.
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PMC11711063
The inhibition of PI3K is a strategy pursued in the treatment of several cancers.
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PMC11683240
PT and α1AT were either directly added to cells for 4 h or preincubated for 15 min before addition to cells.
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PMC11477621
To a solution of 4-(2-bromoethyl)benzoic acid (6) (500 mg, 2.19 mmol) in MeOH (10 mL) was added thionyl chloride (0.3 mL), and the resulting mixture was stirred under refluxing condition for 2 h. The reaction was complete detected by TLC.
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PMC10870498
KIF23, kinesin family member 23; ATC, anaplastic thyroid cancer; Co-IP, Co-immunoprecipitation; HEK, human embryonic kidney; SIRT, sirtuin; succ, succinylation Furthermore, we used the SuccinSite and GPSuc databases to predict KIF23 succinylation sites, and the results showed two possible KIF23 succinylation sites, K437 and K537 (Fig. 4A).
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PMC11190062
p-Values were calculated using two-way ANOVA followed by Sidak’s multiple comparisons test, *p ≤ 0.05, **p ≤ 0.001, ***p ≤ 0.001, ****p ≤ 0.0001.
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PMC9429973
Aims: Aim of the study is the prospective analysis of the acute and early onset cardiotoxicity and outcome of patients with HM.
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PMC11637716
Bone marrow cytogenetics were normal.
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PMC11551844
The absorbance was recorded at 570 nm using a microplate reader (Victor X3-multimode, PerkinElmer, Massachusetts, USA).
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PMC8584666
To clarify the function of GPI-80 in tumor cells, GPI-80-expressing cells and GPI-80/VNN2 gene-deleted cells were established using PC3 prostate cancer cells.
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PMC11248911
C NMR (DMSO-d6, δ ppm): 16.36, 46.60, 63.21, 124.95, 125.20, 125.87, 127.36, 128.40, 128.98, 140.05, 143.32, 159.46, 173.84.
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PMC9429973
Pts with MYD88 were assigned to cohort 2 and received ZANU 160 mg twice daily until disease progression.
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PMC11730311
9cAMP inhibition curves of hαCGRP8-37N25K-C20DA-γGlu and hαCGRP8-37A36S, N25K-C20DA-γGlu.
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PMC11406030
Additionally, LMTK3 is reportedly required for cancer cell proliferation and survival but is dispensable in normal ovarian cells, providing a rationale for developing LMTK3-targeted therapeutics.
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PMC10040136
Four sections were selected randomly from each sample for analysis.
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PMC11025866
The experiments were started with 1 x 10 cells/mL. Sodium butyrate (NaB; Aldrich, >98%) was dissolved in water.
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PMC4839679
Using Sanger sequencing, we identified a previously uncharacterized 4 bp deletion in exon 17, accounting for the loss of protein expression in this cell line (Fig 1C). (
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PMC11350568
CCRF-CEM cells were incubated with 0.3, 1, and 50 nM AptG-1, AptG-2, and Sgc8c∼lib for 30 min in binding buffer at 4 °C. (
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PMC6102174
var.
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PMC10812665
A clear up-regulation was observed for some ceramides related to triggering cell death (e.g., ceramide with two hexanoic acids ) (Figure 7D).
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PMC8584666
It has been reported that redox potential regulates cell proliferation.
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PMC9429973
Only 67% of these transfusion episodes were deemed appropriate, based on the BSH criteria.
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PMC9341513
In vivo, genomic rearrangements are accompanied by chromatin remodeling; within our simulation scheme, it was also possible to examine the effect of a rearrangement in the absence of remodeling.
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PMC11687663
The binding free energy increases with the molecule’s lipophilicity.
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PMC11791478
Tumor growth inhibition was calculated asTumor growth inhibition (%) = 100 × 1- (final MTV - initial MTV of treated group)final MTV - initial MTV of control groupPatient-derived xenograft (PDX) models [bladder, cervical, gastric, head and neck squamous cell carcinoma (HNSCC), and non–small cell lung cancer (NSCLC)] were selected based on H-scores for TF expression between 100 and 200.
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PMC10891340
Mitophagy is a selective form of autophagy by which cells eliminate dysfunctional mitochondria.
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PMC11106977
However, the relevant research is still evolving, and there is a long way to go to take these developments through to clinical applications.
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PMC10158546
While we could not determine the explanation for the resistance of ReN cells to prion infection, our findings reflect the current lack of any immortalized human cell line that are permissive to infection with naturally occurring human prion isolates .
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PMC11098378
Thus, we used bacterial effectors as molecular tools to identify host factors that restrict four distinct arboviruses in lepidopteran cells.
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PMC10919056
RS prognostic model of testing set. (
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PMC11422497
Moreover, to explore the impact of KIT on GISTs, we successfully constructed lentiviral vector-mediated cellular models with KIT overexpression (KIT OE) and silencing (sh-KIT) (P < 0.05; Fig. 6A).
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PMC9429973
In the posttransplant period.
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PMC11718109
The iPSCs and iNeurons were kept at 37 °C with 5% CO2 in an enclosed incubator.
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PMC9429973
Aims: The aim was to distinguish IRIDA from IDA and TT using Sysmex research red cell parameters.
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PMC4112127
The sample size of the tissue study was small but carefully calculated to assess the performance of a single marker in tissues while maximizing the use of scarce specimens.
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PMC11095939
We transfected 40 µg of total DNA (5.7 µg of pAAV8, 11.4 µg of pHelper, and 22.8 µg of TBG-NeonGreen-mir30-shNr1h3 [termed shNr1h3] or 22.8 µg of TBG-NeonGreen-mir30-shRara [termed shRara]) into 293T cells in a 15 cm dish.
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PMC9429973
The most common somatic mutations included: TP53 (N = 10, 23%), FLT3 (N = 7, 16%), RAS (N = 8, 19%), TET2 (N = 7, 16%), and DNMT3A mutations (N = 6, 14%).
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PMC9429973
50 patients will be included and receive Isa-VRd (Isa:10 mg/kg IV Days 1, 8, 15, 22 during cycle 1, QW cycle 2-18; V: 1,3 mg/m SC Days 1,8,15 during cycle 1-8; R: 25 mg PO Days 1-21 during all cycles; d: 20 mg PO Days 1,8,15,22 only for the first 2 cycles), all 28-day cycles.
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PMC9429973
In addition, corresponding karyotype, fluorescence in situ hybridization and SNP-array data of the leukemia samples were integrated and compared to WGOM data.
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PMC11345828
The combined organic layers were dried over MgSO4, filtered, and concentrated.
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PMC9429973
Interestingly, the Simpson clonality negatively correlated with the number of different SARS-CoV-2-specific T cell clonotypes (R=0.86, p=4.8e−06; Figure 1F).
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PMC8316344
Scale bar, 50 μM. C Cell morphology changes of Bel-7404 and SK-Hep1 cells following treating with RSL3 (5 µM) or erastin (10 µM) with or without DFO (25 µM) for indicated hours.
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PMC11419566
Checkpoint control and sequential activation of cyclin-dependent kinase (CDK) regulate cell cycle progression and division.
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PMC8973085
The pyridine nucleus is predominant in numerous natural products as vitamins, coenzymes, and alkaloids (Figure 1).
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PMC11754784
Source data are provided as a Source Data file.
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PMC9812014
It was noted that this alkaloid affected the DENV virus-like particle (VLP) by interfering with the VLP incorporation of the prM-E and C-protein of DENV and reduced the DENV particles by more than 95%.
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PMC11297139
Reasoning from the significant alteration of chromatin opening, we hypothesized that ARID1A LLPS-dependent cRE activation may directly regulate the oncogene expression in Ewing’s sarcoma through modification of chromatin architecture.
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PMC11672881
Calcein-AM/PI dual staining demonstrated the maintained compactness of the control spheroids, which predominantly contained live, green, and fluorescent cells, with a small proportion of red-fluorescing cells observed in the core.
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PMC10854447
IC50 values of compounds 7h, 7i, 7j, 7k, 7l, Erlotinib and Sorafenib against EGFR and VEGFR-2. –,
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PMC8303372
Core-shell NPs of PolyD-L-lactide-co-glycolide (PLGA) coated with chitosan (CS) have an excellent safety profile, good biocompatibility, low levels of immunogenicity and toxicity and tunable in vivo biodegradation rate .
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PMC11599565
If these cells do not utilize these TFs themselves, it is possible that they export them to other target cells.
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PMC11746942
ChIP‒PCR analysis confirming STAT3 binding to the S1PR3 promoter in response to IL-6 treatment (bottom).
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PMC5600151
This review will consider the main types of dendrimer currently being explored and how they can be utilized as drug and gene carriers and functionalized to improve the delivery of cancer therapy.
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PMC10831439
Error bars indicate SE of the mean (SEM), ns p>0.05, *p≤0.05, ****p≤0.0001.
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PMC11301242
2Annotation of the ecDNA amplicons and ecDNA genes.(A) Annotation and (B) functional enrichment analysis of ecDNA amplicon peaks.
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PMC11476004
The tests performed were non-invasive, which means that, in accordance with the Directive, they did not cause pain, suffering, distress, or permanent damage to an extent equal to, or more severe than, a needle-stick injury.
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PMC11769516
It was established that 20.2–31.5% of the administered dose of MON is excreted in urine, while 2% of the administered dose was detected in feces.
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PMC2614416
In addition, all the reactions described in the liver isomerase are oxidoreductase reactions, whereas only one of the three child nodes in the HepG2 isomerase DAG is oxidoreductase.
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PMC11758416
Note: Timing of assay can be adjusted if longer time is required to observe cytotoxic cell death.
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PMC10758402
In addition to DMF, several FMAEs demonstrated a consistent effect on HSV.n212, resulting in an increase in both GFP expression and viral titers in 786-0 cells ( Figure 3 ).
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PMC11496491
This study was approved by the IRB of the authors’ affiliated institutions.
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PMC10978090
8 In this setting, a negative platelet activation assay such as HIPA has been recommended as the target serological endpoint to allow safe surgery, as EIA could remain strongly positive.
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PMC11271800
IDO is a rate-limiting enzyme that catabolizes tryptophan to kynurenine and also induces immunosuppression or participates in the immune escape of tumor cells through high expression levels in the TME, thereby promoting tumor cell survival and growth.
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