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BioData-CellLine_annotated

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PMC11635519
All of the different MCP1-GFP constructions and CCR2 receptor fused with the mCherry fluorescent protein (CCR2-mCherry) were cloned into the pLJM1 nGFP lentiviral vector to evaluate their expression in human embryonic kidney 293 (HEK293) cells.
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PMC6600253
The modulation of the p21 activity has been shown to have a similar effect in inducing the senescence response.
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PMC11429241
In summary, TPP was applied for the microfabrication of scaffolds made of biocompatible photopolymers.
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PMC8973725
ZNF677, a member of the ZNF family, has recently been reported to be downregulated in several different types of cancer owing to promoter hypermethylation [13–15].
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PMC10772747
T47D cells were treated with 10 nM DOX, IC50 EBE, IC50 1,4-naphthoquinone for 24 hours.
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PMC11361748
C–H) PLA assays were performed for (C) K17 and RACK1, (E) RACK1 and phosphor-PKCα (S657) (), and (G) K17 and PKCα in A431 keratinocytes treated with vehicle or TPA for 30 min.
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PMC9429973
In phase 1, patients (n = 8) received brentuximab vedotin 48 mg/m + AVD; dose-limiting toxicity (DLT) was assessed from day 1 of cycle 1 to day 56.
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PMC11518994
This mechanism would therefore cause a PAX5 germline haploinsufficiency instead of a protein variant as in other families.
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PMC10222971
The overall prevalence and incidence of both non-melanoma (basal cell and squamous cell carcinomas) and melanoma skin cancers have increased over the past decades.
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PMC9926039
In previous studies, incubation of isolated natural-killer (NK) cells with methadone has decrease NK cell activity.
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PMC9429973
Summary/Conclusion: We have successfully established AML PDX models for DEK-NUP214 leukaemia that reflect the morphological, immunophenotypic and molecular genetics of this disease subtype.
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PMC8526701
The combinational approach was validated by performing cellular proliferation analysis in both cell types (GIST-T1 and GIST-882 cells).
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PMC11583690
These data indicate that for MSN and BPMO nanoparticles, the loading efficiency is highest at the drug-to-nanomaterial mass ratio of 1:5 and is not significantly different between MSN and BPMO.
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PMC11694625
CDK2 was also regarded as a potentially therapeutic target for compounds containing pyrimidine units.
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PMC11742670
With the aid of DL, FRS, and XAI, Sulfur, and MgO were prioritized, selected, and examined against lung cancer (A-549), human melanoma (A-375), and Human epidermoid skin carcinoma (skin/epidermis) (A-431).
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PMC11509278
Chrysin, glycine sojae, and naringenin in propolis are absorbed by cancer cells, thereby causing the apoptosis of A431 cells.
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PMC9429973
Aims: We aimed to compare the outcomes of 3 cohorts of newly diagnosed AML with favorable cytogenetics who received induction 7 + 3 induction therapy: 1.
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PMC9429973
Analyzing the factors associated with mortality and survival in AML patients with a white blood cell count (WBC) ≥100 x 10/L can guide management and improve early mortality.
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PMC11243198
Unbiased molecular docking simulations were carried out using MOE’s default parameters.
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PMC11714165
Negative control cells were non‐treated, while positive control cells were treated with lysis buffer for 1 h directly.
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PMC11277157
To this end, we compared the PARK7/DJ-1 gene expression in SH-SY5Y neuroblastoma cells as a model for neuronal-like cells , and in HEK293 cells as a non-cancerous cell line.
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PMC11731161
On the next day, membranes were incubated with a secondary antibody for 1 h and detected by enhanced chemiluminescence (Millipore, USA).
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PMC11754784
The hemolysis was calculated using the following equation:[12pt] $$(\%)=_}-(_}-_}))}_}-_})-(_}-_}))}\,*\, 100\%$$%=Asample−Anegative−AcontrolApositive−Acontrol−Anegative−Acontrol*100% To induce the differentiation of macrophage, 1 × 10 THP-1 cells were seeded in 24-well cell culture plates or 4-well confocal dishes, and incubated with 100 ng/ml PMA (Phorbol 12-myristate 13-acetate, MACKLIN, China) for 24 h to induce the THP-1 cells differentiate into M0 macrophages.
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PMC11529598
L. The expression of miR-3154 and TP53INP1 in xenografted tumors detected by qRT-PCR. *
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PMC11678368
Interestingly, cisplatin was less effective against this line (IC50 = 9.96 ± 3.89 µM), indicating that the platinum(II) and palladium(II) complexes may offer an advantage over cisplatin in treating triple-negative breast cancer.
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PMC10944868
Chemical structures of colchicine, vinblastine, docetaxel and DTA0100.
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PMC11684297
In this study, we have used BSA, a non-amyloidogenic protein, as a negative control and observed the IA degradation using ZnO-NFs (25 µg/ml, 50 µg/ml, 75 µg/ml, and 100 µg/ml) by ThT assay (Fig. 7b).
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PMC9046263
We also specifically analyzed HML-6 expression in our cell lines, which is displayed in Fig. 2B.Figure 2Mean HERV expression was highest in the A172 cell line (A), and HML6 is uniquely overexpressed in the A172 and M059J cell lines.
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PMC8992508
As most ABC efflux transporters, P-glycoprotein consists of two N-terminal TMDs and two C-terminal NBDs; each TMD contains six transmembrane segments (-helices).
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PMC11429241
However, considering 3D culture formation, the spheroid-type scaffolds were preferable when comparing the A2780 cell growth between different types of scaffold designs and material bases.
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PMC11609529
RNA-seq analysis of YM target genes and pathways (A) Differentially expressed genes in ES-2 cells after the depletion of YM/MAML2 are shown in Volcano plot.
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PMC11755467
Fusion High-Fidelity PCR master mix with HF buffer (Thermo Fisher, Waltham, MA, USA) was used to amplify the DNA template, and size checking of the PCR product was performed by agarose gel electrophoresis (1.5% agarose, 1× TBE buffer).
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PMC11546117
In the present study, both primary mammary epithelial cells (hMECs) and immortalized cell lines (MCF-7, MCF-10A and PMC42-LA) were evaluated for this purpose.
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PMC11674146
C, D) Effects of CLP36 silencing on the number of EdU-positive lymphoma cells BJAB and RA 1. (
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PMC8494202
Therefore, this study was aimed at exploring the previously unknown relationship between CKAP2L and the biological characteristics of glioma patients, based on clinical sample analysis of multiple databases, and at confirming the oncogenic role of CKAP2L in glioma.
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PMC11472569
MDR can be categorized into two types: intrinsic resistance and acquired resistance.
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PMC9429973
Bioluminescent imaging showed significant reduction in leukemia progression in combination treatment compared to single treatments.
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PMC9429973
Interestingly, patients with del(6q) showed high frequency of chromosome 1 alterations, particularly in the context of CK, associated to poor clinical outcome.
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PMC11731614
Isolation Mode = Quadrupole, isolation window = 1.6, isolation Offset = Off, active type = HCD, collision energy mode = Fixed, HCD collision energy type = Normalized, HCD collision energy = 25%, detector type = Orbitrap, orbitrap resolution = 15K, mass range = Normal, scan range mode = Auto, max injection time mode = Auto, AGC target = Standard, Microscans = 1, data type = Centroid.mins receptively.
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PMC10993311
Endoplasmic reticulum (ER) to Golgi transport vesicle membrane is involved in lipid biosynthesis, calcium storage, and protein processing.
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PMC9429973
In forty patients RS was primarily resistant to administered treatment and 65% of them died due to progression or treatment related complications.
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PMC11596967
For example, in Mycobacterium tuberculosis, 22% of the 2524 genes transcribed during the exponential phase are expressed as lmRNAs .
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PMC11742670
The optical microscope-stained images were recorded as shown in Figs. 7S and 8S (at the supplementary file) comparing the effect of Vidarabine and 5-FU at the same concentration levels.
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PMC11591038
HIF-1 can affect innate immune cells in various aspects in macrophages, dendritic cells, and neutrophils.
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PMC9817179
Understanding situations in which PFA fixation can properly preserve live-cell conditions is essential in judicious applications of fixation-based biological techniques.
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PMC11201989
Lastly, both the primary cilium and the immune synapse exhibit concentrated signal transduction activities.
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PMC11670407
The polyethylene terephthalate (PET) membrane was immersed in 70% methanol to fix the cells, which were subsequently stained by crystal violet solution.
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PMC4277423
We next sorted CCR5 negative cell populations in CEMss-CCR5 cells co-transduced with lentiviral vectors expressing Cas9 and CR2 by FACS.
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PMC9429973
M. van Bergen, P. Kamphuis, I. van Zeventer, J. Salzbrunn, J. J. Schuringa, B. van der Reijden, A. de Graaf, G. Huls, J. Jansen Laboratory medicine, laboratory of hematology, Radboud university medical center, Nijmegen; Hematology, University medical center Groningen, Groningen, Netherlands Background: The blood cell production represents a balance between myeloid and lymphoid progeny.
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PMC9429973
Clinically meaningful improvements in FACIT-Fatigue scores were observed over 48 weeks, with mean (SEM) CFB of 5.3 (1.82) points (mean score 40.7 vs 46.0).
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PMC11790971
An overview of the experimental design is illustrated in Fig. 1.
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PMC9429973
All patients achieved complete remissions with a minimal spectrum of toxicity, which is important when performing alloHCT.
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PMC11740907
In the EGFR-bonded system, only a couple of H-bond interactions are observed.
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PMC10747139
Shereef et al. (2022) studied the cytotoxic activity of the complex [Ru(NO)(Et2NpyS4)]Br (1) and its ligand against human hepatocellular carcinoma (HepG2) cell lines and normal (BNL) cell lines at different concentrations using a WST-1 assay.
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PMC11766174
The prepared slides were scanned using a Zeiss Axioscan (Oberkochen, Germany) and, after acquisition, the images were analyzed and rendered with a digital pathology imaging software (HALO, v3.6.4134, Indica Labs, Albuquerque, NM, USA) .
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PMC11496728
Therefore, adding the Kozak and Leader sequence may enhance translation efficiency when designing tissue-specific vectors.
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PMC11591030
The total RNA extraction from the PBLs was performed using the TRIzol (Takara Bio Inc., Otsu, Japan, Cat.
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PMC11188874
Treatment of either CD8 T cells or cancer cells with the HDAC6 inhibitors alone did not significantly increase the generation of annexin-V/propidium iodide cells (Fig. 7C).
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PMC6337547
The study showed that the increase in SIRT1 was closely related to the p66 isoform (p66shc) of the growth factor adapter Shc.
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PMC11519788
While several signaling pathways, including those driven by STAT3, Hedgehog/Gli1, and Wnt/β-catenin, are known to be active in bladder CSCs, the sustenance of their stem-like properties is intricately regulated by a combination of intrinsic signaling cascades and extrinsic cues from tumor microenvironment (TME) and the broader tumor macroenvironment (TMaE) 8-12.
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PMC11770199
The in vivo antitumor effects observed above were likely primarily due to the lysis of tumor cells induced by mMSCs-p14-mediated cell fusion.
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PMC9429973
Subsequent treatments included eltrombopag (n=13), r-ATG (n=8) CSA (n=6), androgen (n=3) or other (n=4); response to further treatment occurred in 2 (29%) of relapsed and 5 (38%) of refractory patients, with response unknown in 7.
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PMC11786767
All aforementioned images were viewed using a Zeiss LSM700 confocal laser scanning microscope.
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PMC11785489
Applying this to α and β complementarity-determining and framework regions of the TCR yielded 1190 biophysical features.
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PMC7039683
NFRs were identified in cells isolated at 11 hpf; GFP-positive active elements (GPAEs) were the GFP-positive NFRs that overlap H3K27Ac peaks, or H3K27Ac flanked regions, at 8.3 hpf (80% epiboly) and/or at 24 hpf embryos; GNAEs were the GFP-negative NFRs that did so.
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PMC11748335
Furthermore, the H3K27ac and H3K4me3 signals of both groups aligned with the gene expression levels.
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PMC11066331
For analysis, cells were enzymatically detached, washed in phosphate buffered saline, counted, and stored in −80 °C as dry pellets.
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PMC9429973
Methods: An ITC of overall survival (OS) and relapse-free survival (RFS) comparing Oral-AZA vs MIDO was performed, in which data from QUAZAR pts with FLT3-mut AML who had achieved a CR with full blood count recovery (matching RATIFY eligibility criteria) were compared with efficacy outcomes from the RATIFY MT phase (Larson RA, et al. Leukemia 2021).
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PMC9429973
N.I. Pirogov; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia Background: Immunotherapy with checkpoint inhibitors (anti-PD-1) is highly effective in relapsed/refractory (R/R) classical Hodgkin Lymphoma (cHL) and leads to more than 70% overall response rate.
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PMC11052306
However, the gold complexes are highly toxic toward the non-cancerous cells NIH-3T3, whereas the copper complexes are less toxic (Figure 9).
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PMC11248911
The migration ability of the cells was calculated as the ratio of the open area at 24 and 48 hours compared to the open area at zero hours.
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PMC11306019
2009, 146: 270.
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PMC8427838
The slides were analyzed under a fluorescence microscope.
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PMC6114978
Statistical significance determined by two-tailed t-test.
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PMC11343332
Breast cancer is the most prevalent cancer in women worldwide and the main cause of women's cancer-related fatalities .
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PMC10976516
Apart from placental umbilical cord tissue, MSCs can be derived from distinct adult tissues such as bone marrow, peripheral blood, and adipose tissue.
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PMC11767725
Reduced adiponectin, a key anti-inflammatory adipokine, further exacerbates this imbalance .
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PMC11185260
A significant increase in blood urea nitrogen (BUN, 1.3-fold increase from the baseline level), a clinically relevant marker of nephrotoxicity, was also observed in the serum of mice treated with radiation in combination with cisplatin, compared with serum from either untreated mice or mice treated with radiation in combination with scL-SMARCB1.
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PMC11748335
E The enrichment of long LOCKs in S/I/L-PMDs and common HMDs.
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PMC10745221
Interestingly, when PRMT7 was added with Type I and PRMT5 inhibitors, these four bands were not present while a single band near 20 kDa appeared.
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PMC6222635
The anti-proliferation activity of F1 and F3 at concentrations ranging from 25 μg/mL to 400 μg/mL was 24.4%, 22.5%, 24.4%, 35.6%, and 42.5% and 15.2%, 21.7%, 27.0%, 31.6%, and 43.0%, respectively.
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PMC11319300
This region aligns with the human MYEOV-3′-putative enhancer and overlaps with active regions called by ATAC-STARR-seq.
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PMC10900886
Proposed model for systemic dissemination of EV-D68.
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PMC11023271
Similar down-regulation of RIPK4 was observed after FBS treatment (S2 Fig).
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PMC11796104
KEGG pathway enrichment analysis indicated that several pathways were significantly enriched, including Lysine degradation (p = 1.20E-09), Endocytosis (p = 3.39E-09), Metabolic pathways (p = 1.20E-09) and Ubiquitin mediated proteolysis (p = 8.12E-08) (Figure S1D).
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PMC11754432
Cells were seeded onto poly-l-lysine coated µ-Slide 8 Well Glass Bottom (ibidi, Gräfelfing, Germany) and transfected as described above.
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PMC3035438
Conversion to other Ig isoforms, notably IgG, is often desirable for practical use, especially for applications involving the recognition of the Fc region.
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PMC9429973
For high risk myeloma subgroup, 4 trials compared tandem ASCT versus lenalidomide, tandem ASCT demonstrated superior progression free survival (random-effect HR 0.87; 95% CI 0.82–0.91; I2 = 0%) Image: Summary/Conclusion: In conclusion, tandem ASCT are still to be considered as an acceptable treatment options in general myeloma patients.
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PMC11695546
Comparing between impact of crude coconut oil and after exposing to O3 on toxicity % towards A-431 cells at different levels of oils. (
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PMC11700523
The surgeries were performed with intraperitoneal anesthetic administration.
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PMC11638288
However, whether vimentin is the primary cellular ligand for NKp46, or if vimentin stabilizes and enhances the interaction between NKp46 and other cellular ligands, requires further investigation for clarification .
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PMC9429973
Interestingly, 2/27 patients who had suffered from a vascular stroke in the past, also did not develop adequate nAbs (p=0.002).
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PMC9430060
References 1.
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PMC11365427
Among them, the pathways associated with phenylalanine metabolism are significantly affected.
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PMC11765243
Anti-KLH antibodies were assessed in the serum from immunized mice by ELISA.
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PMC6948907
Result of Determination of Cell Viability by MTT Assay The cell vitality in the cells, which treated with GE (25µM, IC50) and VPA (5 µM, IC50) alone and also GE combined with VPA in different time periods (24 and 48h) were analyzed by using the MTT assay.
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PMC11098378
Wild-type GST-IpaH4, but not GST-IpaH4, was capable of ubiquitinating both host proteins in an E1-dependent manner, as evidenced by the formation of higher molecular weight Flag-SHOC2 and PSMC1-His species (Fig 5E and 5F).
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PMC10882807
Because of the lack of early symptoms and signs, most HCC patients are already in the advanced stage at the time of diagnosis.
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PMC9429973
The phase 1b portion endpoint summarizes treatment-emergent dose-limiting toxicities and adverse events to inform the recommended phase 2 dose for each arm.
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PMC11222184
SH-SY5Y cell line was purchased from ATCC (American Type Culture Collection).
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