OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC6642070	However, fluvastatin still increased lactate production in HCT116 SCO2−/− cells despite the non-functional mitochondria (Fig. 2g).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "flu...
PMC11740907	Statistical significance was determined using ANOVA, with a p-value of <0.05 indicating significant differences between the treatment groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", ...
PMC11381192	However, the impact of cellular stress on clinical prognosis of MM patients remains largely unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "impact", "of", "cellular", ...
PMC11770130	Though its primary function is lipid storage, it affects metabolism via various routes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Though", "its", "primary", "function", "is", "lipid", "storage", ...
PMC11406030	CCC, clear cell carcinoma; EC, endometroid carcinoma; HGSC, high-grade serous carcinoma; MC, mucinous carcinoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CCC", ",", "clear...
PMC9429973	In the R/R cohort, 15% had normal, 46% complex karyotype and 31% other.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "R/R", "cohort", ",", ...
PMC11699465	After washing, the cells were incubated with Alexa Fluor 488 Goat Anti-Mouse IgG for 1h.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "washing", ",", "the", "cells", "were", ...
PMC11782508	Additionally, flow cytometry analysis with propidium iodide staining (Fig. 8d-f) indicated that azurin treatment induced cell cycle arrest at the G2/M phase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC5417661	Two days later a small sterile filter paper (5 mm diameter) containing the experimental solution was placed on the CAM between two main blood vessels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10170482	Kinetics of cell dying upon high-fluence, low-power (HFLP) laser irradiation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kinetics", "of", "cell", "dying", "upon", "high-fluence", ",", "low-power",...
PMC11588008	It was consistent with the reports above.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "consistent", "with", "the", "reports", "above", "." ] } ]
PMC8389560	, Fetal Bovine Serum (10099141).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ",", "Fetal", "Bovine", "Serum", "(", "10099141", ")", "." ] } ]
PMC10452486	In addition, in vitro assays demonstrated that HLA-B27-Face-3 interactions with CD4+ T cells induced proinflammatory responses (secretion of TNF and IFN-γ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8633974	Seventy-two hours post-stimulation, cells were harvested, and RNA was extracted. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Seventy-two", "hours", "post-stimulation", ",", "cells", "were", "harvested", ...
PMC7823217	C. GFR Matrigel with formation of 3D acini ™.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C.", "GFR", "Matrigel", "with", "formation", "of", "3D", "acini", "™", "." ] } ]
PMC11467964	Colony formation assay in SW982. (	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Colony", "formation", "assay", "in", "SW982", ".", "(" ] } ]
PMC10482220	Consistent with previous work (Gallouzi et al., 1998; Tourrière et al., 2001), three labeled phosphopeptides characterized the tryptic pattern of immunopurified G3BP (Fig. 3 C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5839394	Moreover, inhibition of HSP90 plays an important role in autophagy inducing degradation of Hsp90 client proteins, such as AKT .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "...
PMC11224020	After removing the confinement, lysis buffer was added directly to recover the confined cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "removing", "the", "confinement", ",", "lysis", "bu...
PMC11637284	The OM module contains three more integral membrane proteins: two beta barrel proteins, TAC40 and TAC42, as well as TAC60 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11502443	The prevalence and severity of diabetes, especially T2D, has stimulated significant interest in developing effective therapies to manage this disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "preva...
PMC7185206	We performed Cox proportional hazards testing between groups of high and low protein-to-mRNA ratios for each malignancy, controlling for age and tumor stage at diagnosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC4112127	We have also reported frequent BMP3 methylation in tissue and stool samples from patients with pancreatic cancers, even at early stage .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have",...
PMC8427838	3Loss of TMIGD1 in mice interferes with moesin and ezrin apical membrane localization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3Loss", "of", "TMIGD1", "in", "mice", "interferes", "with", "moesin", ...
PMC6450504	Briefly, N-Hydroxysuccinimide (NHS) (88 µmol) and ethyl(dimethyl aminopropyl) carbodiimide (EDC) (86 µmol) were solubilized in methanol and added to a chloroform solution containing NGPE (8 µmol) under magnetic stirring, for 1 hour at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10507284	The Fisher Exact test was applied to compare unordered categorical variables.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Fisher", "Exact", "test", "was", "applied", "to", "compare", "unordered", "cat...
PMC11697703	Summary of miR-193b-365, Mapk8 mRNA, and MAPK8 in control superficial and deep cortical neurons, and after miR-193b-365 LoF and GoF. Data are represented as mean ± SEM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11611077	The structure and function of prestin have been increasingly examined in recent years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "structure", "and", "function", "of", "prestin", "have", "been", ...
PMC11794588	As a control, MTT was added to one set of wells with no cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "control", ",", "MTT", "was", "added", "to"...
PMC11705862	However, we did not detect any colocalization between IRIS-1 and 2 and EEA1, as shown by immunofluorescence in (Supplementary Fig. 3), suggesting that IRIS-1 and 2 are preferably localized to secretory vesicles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7039683	Plot of accessibility scores of elements with differential accessibility (i.e., both zGPAEs and zGNAEs) associated with genes that are differentially expressed in GFP-positive and GFP-negative cells, showing that elements with increased accessibility in GFP-positive cells tend to be associated with genes whose expressi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697189	CCK-8 assays were utilized to assess the effects of HSPA7 on the viability of human ccCRC cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "CCK-8", "assays", "were", "utilized...
PMC11367939	B 500 nm (left) or 200 nm (right).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "500", "nm", "(", "left", ")", "or", "200", "nm", "(", "right", ...
PMC11412752	As previously reported, STING is not expressed in primary human hepatocytes and Huh7 cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "As", "previously", "reported", ",", "STING", "is", ...
PMC11763764	This is not only a major clinical challenge but also makes it challenging to obtain recurrent tumor samples for research.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "is", "not", "o...
PMC11040965	P ≤ .001, ****P < .0001, Mann–Whitney test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "≤", ".001", ",", "", "", "", "", ...
PMC9878278	The presence of ZIKV in both the cell-free fraction of seminal fluid and in the sperm head (Mansuy et al., 2016; Stassen et al., 2018) implicates the immune privileged compartment of the testes as one of the reservoirs of long-term persistence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11216402	Scatter plots of correlation to stomach and fibroblast (Fig. 4D,E; Supplemental Figs. S16, S17) show that TCGA-Normal had the highest correlation with ENCODE normal stomach and the lowest with fibroblast, whereas TCGA-STAD tumors have a higher correlation with fibroblast and a lower correlation with stomach (Fig. 4D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544771	Finally, the bands for individual proteins were semi-quantified using NIH ImageJ software (Version 1.51) (National Institutes of Health, Bethesda, MD, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11707577	M13EGFR was finally resuspended in PBS 1x and the phage concentration was deduced by measuring the absorbance at 269 nm in a UV–vis spectrophotometer, using an extinction coefficient of ε = 3.84 cm mg.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10729469	V4XP-3032, Lonza, Basel, Switzerland).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "V4XP-3032", ",", "Lonza", ",", "Basel", ",", "Switzerland", ")", "." ] } ]
PMC5673060	A subset of these proteins feature as part of a protein-protein interaction network centred around the HDAC3 protein (Fig. 5C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "subset"...
PMC9784246	Mass spectra were detected in the ESI negative ion and positive ion modes between m/z 50 and 2000 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mass", "spectra", "were", "detected", ...
PMC11502066	Therefore, in this review article, the current knowledge about the role of GPCRs in anticancer action of structurally varied flavonoids is compiled, highlighting the ability of these natural polyphenols to modulate the expression levels of GPCRs but also suppress the action of endogenous ligands and downstream tumor-pr...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9219615	Similarly, to determine if Tpz-1 stimulates extrinsic apoptosis, we evaluated for the activation of the key initiator, caspase-8; however, we did not detect an increase in activity after 4 h of treatment (Figure S3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11607321	No statistical method was used to predetermine sample size.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "statistical", "method", "was", "used", "to", "predetermine", "sample", "size", "." ] } ]
PMC10530622	Due to clinical association with nephrolithiasis , most evidence regarding oxalate dysmetabolism has been driven by the effects of oxalate in the formation of kidney stones and in kidney function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Recent experimental studies have suggested that complex interactions between the Bcl-2 family of proteins mediate the response to BH3-mimetics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "experimental", "studies", ...
PMC9429973	Median follow-up was 10,2 (6-45) days from the start of treatment to the control of blood counts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "follow-up", ...
PMC11643491	Cells were seeded in six-well plates (200,000 cells/well) and left for 24 h to adhere to the plates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "seeded", ...
PMC11727062	TCM’s multi-component, multi-target approach has shown promise in addressing melanoma’s complexity, with specific monomers demonstrating the ability to modulate tumor behavior.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11001582	Graph, n = 3 mice per genotype, one-way ANOVA, Tukey’s multiple comparison.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Graph", ",", "n", "=", "3", "mice", "per", ...
PMC11519567	Relevant experiments were filmed using a Zeiss 900.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relevant", "experiments", "were", "filmed", "using", "a", "Zeiss", "900", "." ] } ]
PMC11792888	Therefore, it is crucial to research new combinations of drugs that might enhance the efficacy of etoposide and other conventional chemotherapeutics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ...
PMC10344560	Despite technique failure and the mortality rate is still high in early catheter removal, the guideline made a recommendation of immediate PD catheter removal when fungi are identified in PD effluent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11001582	Graph, mean ± s.e.m.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Graph", ",", "mean", "±", "s.e.m", ".", "," ] } ]
PMC11755624	For instance, the identification of crucial cytokines and molecules involved in the progression of psoriasis eventually led to the development of IL-17 inhibitors , TYK2 inhibitors , and IL-36 inhibitors , among others.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747160	This is particularly important for adequately modeling the initiation of COVID-19 infection since SARS-CoV-2 is theorized to rely on attachment and presentation by surface proteins like C-type lectin receptors in order to efficiently infect the low-hACE2-expressing cells of the oral epithelium and respiratory airways .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10761218	Consequently, it can be concluded that substances extracted from W. somnifera have strong antineoplastic activity and could potentially be used as chemotherapeutic agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11806106	We performed a one-phase mono-exponential fit and calculated the half-time of activation (Fig. 4C and Supplementary Fig. 4A–F) and half-time of deactivation (Fig. 4D) for the respective agonist.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10936243	I’ve never thought a cat needs bedding.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "I", "’ve", "never", "thought", "a", "cat", "needs", "bedding", "." ] } ]
PMC7519871	When docked with Bcl-xL, both WDL and BA formed 1 hydrogen bond but Alkyl-Alkyl and Pi-Alkyl interactions were higher in number and stronger for BA as compared to WDL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11683240	The mouse strain used in this study, C57BL/6 mice, express five of these paralogs, SerpinA1a-e.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mouse", "strain", "used", ...
PMC11283030	Staining signals displayed cytoplasmic ACLY and nuclear p-ACLY in adjacent normal kidney and ccRCC tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Staining", "signals", "displayed", "cytoplasmic", "ACLY", "and", ...
PMC8097906	The analysis revealed 25 significantly changed metabolites in VSM and only 5 significantly changed metabolites in cisplatin treatment (at P ≤ 0.01) compared to the non-treated RH-30 cell control (Fig. 5b and Additional file 3: Figure S3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	Diluted LNP samples were deposited and incubated on mica for two minutes, subsequently washed and dried before performing atomic force microscopy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Diluted", "L...
PMC11615218	After antigens are cleared, most TEFF undergo apoptosis, while a small subset survive and persist for years as memory T cells (TMEM), providing recall responses to previously encountered antigens .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10174970	Similarly, DAN-G and Panc 10.05 were PAAD cell lines of primary lesions, the consistent value of DAN-G in the p53 pathway was 0.12, whereas that of Panc 10.05 in the p53 pathway was 0.83.	[ { "tags": [ "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC9429973	Clinical characteristics and pathologic data including cytogenetic (CG) and next generation sequencing (NGS) information were collected at the time of MDS diagnosis (dx), HMA-F, and AML dx.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656657	To corroborate our data in a human setting, we set up different in vitro experimental approaches, summarized in Supplementary Fig. 13.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", ...
PMC11748363	Key observations from these studies include: (1) N‐pyrazinylbenzamides, Figure 1, structure (II) (Zitko et al. 2018) have a superior selectivity profile (lower toxicity) compared to N‐phenylpyrazine‐2‐carboxamides (I) (Zitko et al. 2013); (2) A nitrogen atom at position 1 of the pyridine ring of N‐pyridinylbenzamides i...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10747139	The cytotoxic effects of 14–16 on noncancerous MRC5pd30 cells were significantly lower, thereby demonstrating selectivity toward cancer cells over noncancerous cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11013014	In a dry sealed tube under argon, the pharmacophore 19 (5 mmol) is solubilised in an acetonitrile/DMF (4/1: v/v); then distilled triethylamine (10 mmol) and alkyne compound 21 (10 mmol) are added.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770199	Then, hMSCs transfected with PCDH-GFP or PCDH-GFP-p14 were mixed with HCT8 and A375 cells in a ratio of 1:5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", ",", ...
PMC11519583	b Representative images of MPs at 3 days after transfection with the respective siRNAs, followed by staining with anti-Ki-67 antibody (magenta) and DAPI (cyan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705547	Monoclonal antibodies targeting PD-1 and PD-L1 have been successful in treating a wide range of cancer types , and have demonstrated durable therapeutic activity in several clinical trials [142–144].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9105697	In order to determine the sensitivity and specificity of our technique for ctDNA detection, a breakpoint panel that included the breakpoint region of 15 SS patients (patient 1 to patient 15) was designed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In the group of CD269 positive patients, sBCMA concentration was significantly (p=0.001) higher than in CD269 negative group: medians were 5334.12pg/ml (1933.6-11617.3) vs 318.87pg/ml (122.3-3962.2), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11357960	PBMC were isolated from lung cancer patients who received anti-PD-1 immunotherapy for 9 weeks by using Ficoll-Hypaque (Sigma Aldrich, USA) density gradient centrifugation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11700165	Notably, we observed that ITK-SYK undergoes activation-mediated nuclear translocation, a phenomenon that is uncommon among kinases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Notably", ",", "we", "observed", "that...
PMC10890307	We carried out the metabolic characterization of four lung tumor cell lines (A427, A549, Calu-1, and SK-MES-1), fibroblast cells (MRC-5), and a breast cancer cell line (MCF-7) in different culture conditions that emulate various tumor microenvironment conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", ...
PMC11612315	The cells were mechanically dissociated via gentle pipetting and placed on glass coverslips coated with poly-D-lysine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "mechanically", "dissociated", ...
PMC11564322	In the K562 cell line, both VGVAPG and VVGPGA peptides increased ELANE mRNA by 293.64 and 151.09%, respectively, compared to the control (Fig. 2E).	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11228511	A detailed description is provided in SI Appendix.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "detailed", "description", "is", "provided", "in", "SI", "Appendix", "." ] } ]
PMC11741577	Our findings indicated that TLR2/6-stimulated mast cells contributed to skin homeostasis by promoting tryptase-dependent wound healing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "findings", "indicated", "that", "TLR2/6-stimulated", ...
PMC11106977	These findings may inform future treatments for RA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "may", "inform", "future", "treatments", "for", "RA", "." ] } ]
PMC11618052	The structures of 8a–t were elucidated using H NMR, C NMR spectroscopy, and LC-MS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "structures", "of", "8a", "–", ...
PMC11770130	Hisat2 was used to construct the index of the reference genome and aligned with clean reads at the end of the reference genome pair.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11755467	In summary, we provide data that in vitro administration of Enoxacin exhibits a repressive effect on HIV-1 replication in the T-cell line CEM-SS, eventually by inhibiting maturation of the pro-HIV-1 hsa-miR-132-3p.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", ...
PMC11731614	We then applied these fluorescently labeled KDEVs to primary DRG neuron cultures and observed a robust uptake of these KDEVs by both the cell bodies and neurites of the neurons (Fig. 2D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519583	Osaka, Japan], and 1 mM p-APMSF [FUJIFILM Wako Pure Chemical Corporation]).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Osaka", ",", "Japan", "]", ",", "and", ...
PMC10965315	But this cell line may not be representative of other types of OC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "But", "this", "cell", "line", "may", "not", "be", "representativ...
PMC11422150	Results were normalized with GAPDH expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "were", "normalized", "with", "GAPDH", "expression", "." ] } ]
PMC10470467	Based on the above findings, 3 genes will probably become novel therapeutic targets for ES.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "the", "above", "findings", ",", "...
PMC9429973	Median overall survival (OS) were 5.9 months in the R/R group and 9.4 months in the ND group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "overall", "surviva...
PMC11772449	After the experiment, fixed with paraformaldehyde, and then stained with crystal violet, and photographed and analyzed with the corresponding equipment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After",...
PMC10114490	Moreover, these activities were induced under canonical CYP450 chemical inducers, i.e., phenobarbital and rifampicin (Fig. 4F).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "these", ...
PMC7757104	In accordance with this hypothesis, our recent study demonstrated that ectopic overexpression of OPNb and OPNc in PC3 prostate cancer cells induced resistance to docetaxel (19), suggesting that overexpression of specific OPN-SIs may differentially contribute to tumor drug resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC10589262	PF429242 (Tocris, Ellisville, MO, USA), Ceapin-A7 (Sigma), and melatonin (Sigma) were used to inhibit ATF6 activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787381	Further developments in the IN route and formulation are necessary before clinical trials can be conducted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "developments", "in", "the", "IN", "route", ...

PMC6642070

However, fluvastatin still increased lactate production in HCT116 SCO2−/− cells despite the non-functional mitochondria (Fig. 2g).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "flu...

PMC11740907

Statistical significance was determined using ANOVA, with a p-value of <0.05 indicating significant differences between the treatment groups.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "significance", ...

PMC11381192

However, the impact of cellular stress on clinical prognosis of MM patients remains largely unknown.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "impact", "of", "cellular", ...

PMC11770130

Though its primary function is lipid storage, it affects metabolism via various routes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Though", "its", "primary", "function", "is", "lipid", "storage", ...

PMC11406030

CCC, clear cell carcinoma; EC, endometroid carcinoma; HGSC, high-grade serous carcinoma; MC, mucinous carcinoma.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CCC", ",", "clear...

PMC9429973

In the R/R cohort, 15% had normal, 46% complex karyotype and 31% other.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "R/R", "cohort", ",", ...

PMC11699465

After washing, the cells were incubated with Alexa Fluor 488 Goat Anti-Mouse IgG for 1h.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "washing", ",", "the", "cells", "were", ...

PMC11782508

Additionally, flow cytometry analysis with propidium iodide staining (Fig. 8d-f) indicated that azurin treatment induced cell cycle arrest at the G2/M phase.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC5417661

Two days later a small sterile filter paper (5 mm diameter) containing the experimental solution was placed on the CAM between two main blood vessels.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10170482

Kinetics of cell dying upon high-fluence, low-power (HFLP) laser irradiation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kinetics", "of", "cell", "dying", "upon", "high-fluence", ",", "low-power",...

PMC11588008

It was consistent with the reports above.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "was", "consistent", "with", "the", "reports", "above", "." ] } ]

PMC8389560

, Fetal Bovine Serum (10099141).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ",", "Fetal", "Bovine", "Serum", "(", "10099141", ")", "." ] } ]

PMC10452486

In addition, in vitro assays demonstrated that HLA-B27-Face-3 interactions with CD4+ T cells induced proinflammatory responses (secretion of TNF and IFN-γ).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC8633974

Seventy-two hours post-stimulation, cells were harvested, and RNA was extracted. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Seventy-two", "hours", "post-stimulation", ",", "cells", "were", "harvested", ...

PMC7823217

C. GFR Matrigel with formation of 3D acini ™.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C.", "GFR", "Matrigel", "with", "formation", "of", "3D", "acini", "™", "." ] } ]

PMC11467964

Colony formation assay in SW982. (

[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Colony", "formation", "assay", "in", "SW982", ".", "(" ] } ]

PMC10482220

Consistent with previous work (Gallouzi et al., 1998; Tourrière et al., 2001), three labeled phosphopeptides characterized the tryptic pattern of immunopurified G3BP (Fig. 3 C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5839394

Moreover, inhibition of HSP90 plays an important role in autophagy inducing degradation of Hsp90 client proteins, such as AKT .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "...

PMC11224020

After removing the confinement, lysis buffer was added directly to recover the confined cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "removing", "the", "confinement", ",", "lysis", "bu...

PMC11637284

The OM module contains three more integral membrane proteins: two beta barrel proteins, TAC40 and TAC42, as well as TAC60 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...

PMC11502443

The prevalence and severity of diabetes, especially T2D, has stimulated significant interest in developing effective therapies to manage this disease.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "preva...

PMC7185206

We performed Cox proportional hazards testing between groups of high and low protein-to-mRNA ratios for each malignancy, controlling for age and tumor stage at diagnosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC4112127

We have also reported frequent BMP3 methylation in tissue and stool samples from patients with pancreatic cancers, even at early stage .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "have",...

PMC8427838

3Loss of TMIGD1 in mice interferes with moesin and ezrin apical membrane localization.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "3Loss", "of", "TMIGD1", "in", "mice", "interferes", "with", "moesin", ...

PMC6450504

Briefly, N-Hydroxysuccinimide (NHS) (88 µmol) and ethyl(dimethyl aminopropyl) carbodiimide (EDC) (86 µmol) were solubilized in methanol and added to a chloroform solution containing NGPE (8 µmol) under magnetic stirring, for 1 hour at room temperature.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10507284

The Fisher Exact test was applied to compare unordered categorical variables.

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PMC11697703

Summary of miR-193b-365, Mapk8 mRNA, and MAPK8 in control superficial and deep cortical neurons, and after miR-193b-365 LoF and GoF. Data are represented as mean ± SEM.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11611077

The structure and function of prestin have been increasingly examined in recent years.

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PMC11794588

As a control, MTT was added to one set of wells with no cells.

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PMC11705862

However, we did not detect any colocalization between IRIS-1 and 2 and EEA1, as shown by immunofluorescence in (Supplementary Fig. 3), suggesting that IRIS-1 and 2 are preferably localized to secretory vesicles.

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PMC7039683

Plot of accessibility scores of elements with differential accessibility (i.e., both zGPAEs and zGNAEs) associated with genes that are differentially expressed in GFP-positive and GFP-negative cells, showing that elements with increased accessibility in GFP-positive cells tend to be associated with genes whose expressi...

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PMC11697189

CCK-8 assays were utilized to assess the effects of HSPA7 on the viability of human ccCRC cell lines.

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PMC11367939

B 500 nm (left) or 200 nm (right).

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PMC11412752

As previously reported, STING is not expressed in primary human hepatocytes and Huh7 cells .

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PMC11763764

This is not only a major clinical challenge but also makes it challenging to obtain recurrent tumor samples for research.

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PMC11040965

P ≤ .001, ****P < .0001, Mann–Whitney test.

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PMC9878278

The presence of ZIKV in both the cell-free fraction of seminal fluid and in the sperm head (Mansuy et al., 2016; Stassen et al., 2018) implicates the immune privileged compartment of the testes as one of the reservoirs of long-term persistence.

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PMC11216402

Scatter plots of correlation to stomach and fibroblast (Fig. 4D,E; Supplemental Figs. S16, S17) show that TCGA-Normal had the highest correlation with ENCODE normal stomach and the lowest with fibroblast, whereas TCGA-STAD tumors have a higher correlation with fibroblast and a lower correlation with stomach (Fig. 4D).

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PMC11544771

Finally, the bands for individual proteins were semi-quantified using NIH ImageJ software (Version 1.51) (National Institutes of Health, Bethesda, MD, USA).

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PMC11707577

M13EGFR was finally resuspended in PBS 1x and the phage concentration was deduced by measuring the absorbance at 269 nm in a UV–vis spectrophotometer, using an extinction coefficient of ε = 3.84 cm mg.

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PMC10729469

V4XP-3032, Lonza, Basel, Switzerland).

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PMC5673060

A subset of these proteins feature as part of a protein-protein interaction network centred around the HDAC3 protein (Fig. 5C).

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PMC9784246

Mass spectra were detected in the ESI negative ion and positive ion modes between m/z 50 and 2000 .

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PMC11502066

Therefore, in this review article, the current knowledge about the role of GPCRs in anticancer action of structurally varied flavonoids is compiled, highlighting the ability of these natural polyphenols to modulate the expression levels of GPCRs but also suppress the action of endogenous ligands and downstream tumor-pr...

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PMC9219615

Similarly, to determine if Tpz-1 stimulates extrinsic apoptosis, we evaluated for the activation of the key initiator, caspase-8; however, we did not detect an increase in activity after 4 h of treatment (Figure S3).

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PMC11607321

No statistical method was used to predetermine sample size.

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PMC10530622

Due to clinical association with nephrolithiasis , most evidence regarding oxalate dysmetabolism has been driven by the effects of oxalate in the formation of kidney stones and in kidney function.

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PMC9429973

Recent experimental studies have suggested that complex interactions between the Bcl-2 family of proteins mediate the response to BH3-mimetics.

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PMC9429973

Median follow-up was 10,2 (6-45) days from the start of treatment to the control of blood counts.

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PMC11643491

Cells were seeded in six-well plates (200,000 cells/well) and left for 24 h to adhere to the plates.

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PMC11727062

TCM’s multi-component, multi-target approach has shown promise in addressing melanoma’s complexity, with specific monomers demonstrating the ability to modulate tumor behavior.

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PMC11001582

Graph, n = 3 mice per genotype, one-way ANOVA, Tukey’s multiple comparison.

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PMC11519567

Relevant experiments were filmed using a Zeiss 900.

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PMC11792888

Therefore, it is crucial to research new combinations of drugs that might enhance the efficacy of etoposide and other conventional chemotherapeutics.

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PMC10344560

Despite technique failure and the mortality rate is still high in early catheter removal, the guideline made a recommendation of immediate PD catheter removal when fungi are identified in PD effluent.

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PMC11001582

Graph, mean ± s.e.m.,

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PMC11755624

For instance, the identification of crucial cytokines and molecules involved in the progression of psoriasis eventually led to the development of IL-17 inhibitors , TYK2 inhibitors , and IL-36 inhibitors , among others.

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PMC10747160

This is particularly important for adequately modeling the initiation of COVID-19 infection since SARS-CoV-2 is theorized to rely on attachment and presentation by surface proteins like C-type lectin receptors in order to efficiently infect the low-hACE2-expressing cells of the oral epithelium and respiratory airways .

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PMC10761218

Consequently, it can be concluded that substances extracted from W. somnifera have strong antineoplastic activity and could potentially be used as chemotherapeutic agents.

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PMC11806106

We performed a one-phase mono-exponential fit and calculated the half-time of activation (Fig. 4C and Supplementary Fig. 4A–F) and half-time of deactivation (Fig. 4D) for the respective agonist.

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PMC10936243

I’ve never thought a cat needs bedding.

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PMC7519871

When docked with Bcl-xL, both WDL and BA formed 1 hydrogen bond but Alkyl-Alkyl and Pi-Alkyl interactions were higher in number and stronger for BA as compared to WDL.

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PMC11683240

The mouse strain used in this study, C57BL/6 mice, express five of these paralogs, SerpinA1a-e.

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PMC11283030

Staining signals displayed cytoplasmic ACLY and nuclear p-ACLY in adjacent normal kidney and ccRCC tissues.

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PMC8097906

The analysis revealed 25 significantly changed metabolites in VSM and only 5 significantly changed metabolites in cisplatin treatment (at P ≤ 0.01) compared to the non-treated RH-30 cell control (Fig. 5b and Additional file 3: Figure S3).

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PMC8633974

Diluted LNP samples were deposited and incubated on mica for two minutes, subsequently washed and dried before performing atomic force microscopy.

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PMC11615218

After antigens are cleared, most TEFF undergo apoptosis, while a small subset survive and persist for years as memory T cells (TMEM), providing recall responses to previously encountered antigens .

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PMC10174970

Similarly, DAN-G and Panc 10.05 were PAAD cell lines of primary lesions, the consistent value of DAN-G in the p53 pathway was 0.12, whereas that of Panc 10.05 in the p53 pathway was 0.83.

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PMC9429973

Clinical characteristics and pathologic data including cytogenetic (CG) and next generation sequencing (NGS) information were collected at the time of MDS diagnosis (dx), HMA-F, and AML dx.

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PMC11656657

To corroborate our data in a human setting, we set up different in vitro experimental approaches, summarized in Supplementary Fig. 13.

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PMC11748363

Key observations from these studies include: (1) N‐pyrazinylbenzamides, Figure 1, structure (II) (Zitko et al. 2018) have a superior selectivity profile (lower toxicity) compared to N‐phenylpyrazine‐2‐carboxamides (I) (Zitko et al. 2013); (2) A nitrogen atom at position 1 of the pyridine ring of N‐pyridinylbenzamides i...

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PMC10747139

The cytotoxic effects of 14–16 on noncancerous MRC5pd30 cells were significantly lower, thereby demonstrating selectivity toward cancer cells over noncancerous cells.

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PMC11013014

In a dry sealed tube under argon, the pharmacophore 19 (5 mmol) is solubilised in an acetonitrile/DMF (4/1: v/v); then distilled triethylamine (10 mmol) and alkyne compound 21 (10 mmol) are added.

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PMC11770199

Then, hMSCs transfected with PCDH-GFP or PCDH-GFP-p14 were mixed with HCT8 and A375 cells in a ratio of 1:5.

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PMC11519583

b Representative images of MPs at 3 days after transfection with the respective siRNAs, followed by staining with anti-Ki-67 antibody (magenta) and DAPI (cyan).

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PMC11705547

Monoclonal antibodies targeting PD-1 and PD-L1 have been successful in treating a wide range of cancer types , and have demonstrated durable therapeutic activity in several clinical trials [142–144].

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PMC9105697

In order to determine the sensitivity and specificity of our technique for ctDNA detection, a breakpoint panel that included the breakpoint region of 15 SS patients (patient 1 to patient 15) was designed.

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PMC9429973

In the group of CD269 positive patients, sBCMA concentration was significantly (p=0.001) higher than in CD269 negative group: medians were 5334.12pg/ml (1933.6-11617.3) vs 318.87pg/ml (122.3-3962.2), respectively.

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PMC11357960

PBMC were isolated from lung cancer patients who received anti-PD-1 immunotherapy for 9 weeks by using Ficoll-Hypaque (Sigma Aldrich, USA) density gradient centrifugation.

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PMC11700165

Notably, we observed that ITK-SYK undergoes activation-mediated nuclear translocation, a phenomenon that is uncommon among kinases.

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PMC10890307

We carried out the metabolic characterization of four lung tumor cell lines (A427, A549, Calu-1, and SK-MES-1), fibroblast cells (MRC-5), and a breast cancer cell line (MCF-7) in different culture conditions that emulate various tumor microenvironment conditions.

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PMC11612315

The cells were mechanically dissociated via gentle pipetting and placed on glass coverslips coated with poly-D-lysine.

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PMC11564322

In the K562 cell line, both VGVAPG and VVGPGA peptides increased ELANE mRNA by 293.64 and 151.09%, respectively, compared to the control (Fig. 2E).

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PMC11228511

A detailed description is provided in SI Appendix.

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PMC11741577

Our findings indicated that TLR2/6-stimulated mast cells contributed to skin homeostasis by promoting tryptase-dependent wound healing.

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PMC11106977

These findings may inform future treatments for RA.

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PMC11618052

The structures of 8a–t were elucidated using H NMR, C NMR spectroscopy, and LC-MS.

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PMC11770130

Hisat2 was used to construct the index of the reference genome and aligned with clean reads at the end of the reference genome pair.

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PMC11755467

In summary, we provide data that in vitro administration of Enoxacin exhibits a repressive effect on HIV-1 replication in the T-cell line CEM-SS, eventually by inhibiting maturation of the pro-HIV-1 hsa-miR-132-3p.

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PMC11731614

We then applied these fluorescently labeled KDEVs to primary DRG neuron cultures and observed a robust uptake of these KDEVs by both the cell bodies and neurites of the neurons (Fig. 2D).

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PMC11519583

Osaka, Japan], and 1 mM p-APMSF [FUJIFILM Wako Pure Chemical Corporation]).

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PMC10965315

But this cell line may not be representative of other types of OC cells.

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PMC11422150

Results were normalized with GAPDH expression.

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PMC10470467

Based on the above findings, 3 genes will probably become novel therapeutic targets for ES.

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PMC9429973

Median overall survival (OS) were 5.9 months in the R/R group and 9.4 months in the ND group.

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PMC11772449

After the experiment, fixed with paraformaldehyde, and then stained with crystal violet, and photographed and analyzed with the corresponding equipment.

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PMC10114490

Moreover, these activities were induced under canonical CYP450 chemical inducers, i.e., phenobarbital and rifampicin (Fig. 4F).Fig.

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PMC7757104

In accordance with this hypothesis, our recent study demonstrated that ectopic overexpression of OPNb and OPNc in PC3 prostate cancer cells induced resistance to docetaxel (19), suggesting that overexpression of specific OPN-SIs may differentially contribute to tumor drug resistance.

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PMC10589262

PF429242 (Tocris, Ellisville, MO, USA), Ceapin-A7 (Sigma), and melatonin (Sigma) were used to inhibit ATF6 activation.

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PMC11787381

Further developments in the IN route and formulation are necessary before clinical trials can be conducted.

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