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BioData-CellLine_annotated

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PMC11666785
SMLM techniques are in their early stages and the emerging potential variants are expected to reveal fundamental aspects of biological processes in the coming decade.
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PMC11469524
We include the stimulated node s in the network and attribute the stimulation strength to the local response coefficients directly reached by node s and set the corresponding entry in p to 1.
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PMC9676986
Thus, systemic diagnostics of signaling pathways using molecular assays and/or multi-omics will help select patients whose cancer cells respond to FGF inhibitors, thereby improving therapeutic outcomes of the targeted subtypes (Heo et al., 2021).
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PMC8193046
The determined IC50 values of compounds that resulted in an inhibition level of ≥20% [+ standard error or the mean (SEM)] in the preliminary screening (Fig. 7 A–C) determined in calcein AM (ABCB1 and ABCC1) and pheophorbide A (ABCG2) assays, respectively, applying ABCB1-overexpressing A2780/ADR, ABCC1-overexpressing H6...
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PMC11525028
The Asn level also decreased in ATF4-KD osteosarcoma cell lines (Figure 4L).
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PMC8662250
Interestingly, a previous study by Anil group observed a similar decrease of the ACE‐2 receptor in lung epithelial cells induced by CBD (Anil et al., 2021).
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PMC10589262
GIST882 cells harboring the homozygous KIT mutation were used for analysis.
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PMC11762280
For a long time, researches have focused on the role of ZBP1 in sensing nucleic acid during cell death induced by bacterial, virus, or fungi infections [40, 42–45].
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PMC9429973
Image: Summary/Conclusion: Inhibition of CTPS1 by single agent STP938 showed anti-proliferative activity against 6 of 12 myeloma cell lines, and induced replication stress in all cell lines.
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PMC11700340
Another study demonstrated that Linagliptin can inhibit cell viability, proliferation, and migration in Glioblastoma cancer cells.
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PMC10565698
9 Mechanistic sketch of the role of circUSP10 in LC.
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PMC10729469
Isotypes and FMO (fluorescence-minus-one) were used for accurate gating.
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PMC9429973
FGF23 inhibition provides a novel strategy to target bone defects and HSC-BM niche interactions and could be a valuable strategy to improve HSC transplantation and gene therapy approaches for BT.
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PMC11474209
Advanced oxidation processes (AOPs) have garnered significant attention for their applications in drinking and wastewater treatment.
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PMC11397654
They were obtained from the corresponding tetra-, hexa- or octa-p-tert-butylcalix[n]arenes (n = 4, 6, 8) by reaction with chlorosulfonic acid, and the resulting chlorosulfonated derivatives were treated with either N,N′-dimethylethylenediamine or N-Boc-ethylenediamine.
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PMC11248911
HNMR (DMSO-d6, δ ppm): 2.01 (s, 3H, CH3), 2.94–3.01 (dd, 1H, pyrazoline, J = 7.32, 17.44 Hz), 3.33–3.40 (dd, 1H, pyrazoline, J = 11.28, 17.44 Hz), 5.22–5.27 (dd, 1H, pyrazoline, J = 7.88, 10.58 Hz), 7.23–7.30 (m, 5H, Ar–H), 7.52 (s, 2H, Ar–H).
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PMC8956657
A Maximum likelihood tree of complete genome sequences of select viruses within subgenus Merbecovirus.
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PMC11476837
The 80 µg of proteins was separated on 10% SDS-PAGE and transferred to PVDF transfer membrane (ThermoFisher Scientific, Waltham, MA, USA).
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PMC9429973
There were no tx-related deaths; most tx-related grade (gr) ≥3 (94%) and serious (52%) adverse events occurred ≤8 w post infusion.
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PMC11632064
By matching each gene with the gene essentiality (CRISPR/Cas9) data from the DepMap portal, we found that a major fraction of “sensitizing” and “resistance” genes are classified as nonessential (Fig 7D), which opens the possibility of exploiting the targeting of these genes for experimental and therapeutic purposes.
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PMC9822769
However, the results obtained so far point to the involvement of an active/facilitated transport that is complementary/alternative to passive diffusion.
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PMC8170755
This was further accompanied by lower expressions of MMP-2 and MMP-9 genes.
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PMC11730311
Plasma proteins were removed by addition of 1:4 plasma:MeOH (v/v) followed by centrifugation at 2670 × g for 40 min at 4 °C.
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PMC11477621
H NMR (400 MHz, CD3OD) δ 7.85–7.82 (overlap, 3H), 7.72 (dd, J = 8.5, 2.0 Hz, 1H), 7.53 (s, 1H), 7.18–7.14 (overlap, 2H), 7.13–7.11 (m, 1H), 7.11–7.08 (m 1H), 6.85 (d, J = 8.5 Hz, 1H), 6.18 (dd, J = 4.2, 2.5 Hz, 1H), 5.55 (s, 2H), 4.65 (t, J = 6.8 Hz, 2H), 3.83 (s, 3H), 3.25 (t, J = 6.8 Hz, 2H), 2.39 (s, 3H).
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PMC11706776
E Expression of KCNN1 in normal tissues from GTEx database.
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PMC11106977
Mechanically, TNF-α enhances osteoclastogenesis in inflammatory arthritis by increasing the expression levels of OGT and OGA.
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PMC11754094
Cells (2.5 × 10) were transfected with 750 ng of Cas9 expression plasmids and 250 ng of sgRNA expression plasmids with the following parameters: 1,050 V, 30 ms, 2 pulse for U2OS, and 1,350 V, 10 ms, 4 pulse for K562.
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PMC5854676
Figure 7Cell viability loss in HeLa cell line exposed to MgO nanotubes in the dark and with 660 nm laser irradiation.
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PMC11763126
Scratches were created in the cell monolayer, CBDP1 or Scr peptide was applied, and wound healing progress was observed over 24 h. Images were captured and wound healing rates were analyzed using ImageJ software.
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PMC11119602
Under normal conditions, when intracellular calcium levels are low (100–200 nM) and GTP levels are high (0.1–1 mM), TG2-L’s relatively high Km (1–5 µM) for calcium is thought to reflect its ‘closed’ and enzymically inactive conformation, allowing it to function simply as an accessory adhesion protein that is protective...
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PMC11655498
The expression of Zta and Rta marks the onset of the EBV lytic cycle, initiating a multi-stage biological process in which EBV-encoded lytic proteins and various host factors play complex and pivotal roles.
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PMC11575040
Briefly, sequences of LINC00094 were cloned into a pMIR-REPROT vector (AM5795; Thermo Fisher Scientific, Waltham, MA, USA).
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PMC11365427
MS spectra were searched against the Uniprot Homo sapiens Swiss-Prot proteome database.
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PMC11679892
Early diagnosis and treatment of these cancers are of great importance for both the course of the disease and the quality of life of patients.
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PMC9429973
L. Vinti, S. Daw, C. Sabado Alvarez, F. Fagioli, A. Beishuizen, G. Michel, M. L. Moleti, M. Cepelova, A. Thorwarth, C. Rigaud, D. Plaza Lopez de Sabando, J. Landman Parker, Y. Zhu, P. Pillai, A. Nahar, C. Mauz-Koerholz IRCCS Ospedale Pediatrico Bambino, Gesu, Italy; University College London Hospitals NHS Foundation Tr...
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PMC11361748
Significant amounts of RACK1 and PKCα are extracted by the low salt buffer, as expected, while RACK1 but not PKCα also occurs in the Triton-soluble pool (S5D Fig).
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PMC8973085
Yellow solid [A] (88%); [B] (73%); mp: 200–202 °C (EtOH); IR (KBr, v, cm): 3467–3297 (NH2), 3142 (NH), 1674 (C=O), 1652 (C=O); H NMR (DMSO-d6): δ 2.37 (s, 3H, CH3), 2.65 (s, 3H, CH3), 3.63 (s, 3H, OCH3), 3.65 (s, 3H, OCH3), 6.99–7.46 (m, 9H, CH-Ar + NH2), 10.38 (bs, 1H, NH); C NMR (DMSO-d6): δ 23.14, 29.55, 56.00, 56.6...
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PMC11763126
YTHDF2 is an N6-methyladenosine (m6A)-binding protein known to regulate mRNA stability .
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PMC9429973
In addition, the impact of γc cytokine signaling blockade on lymphocyte populations in vivo were investigated in CM in a single dose pharmacokinetic/pharmacodynamic study and a repeat-dose toxicology study.
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PMC11739504
More interestingly, their acetylome data uncovered many proteins related not only to motor proteins but also to other primary ciliary proteins that could be acetylated by Kat2b; for instance, ALMS1 is an Alstrom syndrome gene, which is ciliopathic.
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PMC11406030
Our initial data with low doses (2 mg/kg IV) of LMTK3BP #1 and #2 showed a 24% and 35% tumor reduction, respectively.
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PMC9429973
Image: Summary/Conclusion: This study demonstrates novel therapeutic opportunities for augmenting immune responses in poorly immunogenic tumors and increasing their responsiveness to immunotherapies.
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PMC9100622
Mice were treated every day by intraperitoneal injection of DMSO or Atorvastatin (10 mg/kg/day) until one mouse reached the ethic size volume of 2000–2500 mm, measured by the formula V = D × d/2, where D is the largest diameter and d the smallest one.
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PMC11291697
At Stanford-Binet test, the IQ was 31.
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PMC11758416
Cytotoxicity of memory CD8+ T cells was inhibited by exposure to concanamycin A. n = 6.
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PMC11757230
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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PMC11489351
Fig. S3B was created using Microsoft Excel and modified in Adobe Illustrator Metacore (Clarivate) was used to analyze RNA-Seq datasets.
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PMC9917080
Therefore, there is a need to create new methods for delivering sorafenib to brain tumors, enhancing the therapeutic potential of sorafenib and reducing the cytotoxic effects of active compounds on the healthy environment of tumors, and ideally, increasing the survival of healthy cells during therapy.
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PMC11224020
We next asked whether nuclear translocation and activation of cPLA2 resulted from passive stretching of the DC nucleus after confinement or instead required an active cellular response.
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PMC11785489
Strikingly, the TCR-mem difference between SP and DP thymic T cells was statistically indistinguishable from the TCR-mem difference between memory and naive peripheral T cells (heterogeneity p = 0.86).
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PMC11621565
Lipopolysaccharide (LPS) from Escherichia.
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PMC11737091
Compared with other subtypes of RCC, ccRCC usually results in worse patient outcomes .
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PMC10495912
After determination of IC50 for TQ, the HepG2 cells were pretreated with concentrations of 18.5, 37 and 75 µM of TQ (~10-40% of IC50) before being exposed to various concentrations of hydrogen peroxide.
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PMC11377827
A 200 µl aliquot of the remaining sample was diluted with ChIP dilution buffer to 1 ml, and precleared using 25 µl Protein G magnetic beads (4 °C, 2 h, rotating); 1 ml of sample was immunoprecipitated with the appropriate primary antibody (4 °C, overnight, rotating).
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PMC11788920
Even though significantly higher than the control (1.56 ± 0.07-fold), the enhancement at the protein level in case of RNP1 was lower compared to the increase at mRNA level (1.56 ± 0.07-fold in protein level compared to 2.14 ± 0.07 at mRNA level).
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PMC9429973
Dose escalation via IV and subcutaneous routes continues, and data will be updated.
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PMC11674441
All patients underwent Neo-P DC vaccine as adjuvant settings along with standard treatment (Table 1).
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PMC11683240
The sterile filtrate (1000 l) was diluted with deionized water to a conductivity value below 8 mS/cm, conditioned to pH 2.7 using hydrochloric acid (HCl), and then loaded at a flow rate of 65 ml/min onto a 40 × 15 cm strong cation-exchanger Fractogel TSK SP 650(M) (Merck), followed by a washing step using 0.01 M HCl.
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PMC11462673
SUP-T1and PF-382 were obtained from Zhejiang Meisen Cell Technology Co.,Ltd.
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PMC10114490
We have analyzed the cell extracts of HepG2 and diHLC-T incubated with reference hepatotoxicants to obtain a predictive model of toxicity caused by these drugs in both cell models.
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PMC9966931
Novozym 435 is Candida antarctica B lipase (CALB) immobilized on acrylic resin.
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PMC11127909
To test our hypothesis, we analyzed mitochondrial morphology by transmission electron microscopy (TEM) and confocal laser scanning microscopy.
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PMC11499381
DNA was modified using an InFusion kit (Cat# 639650, Takara Biosciences, San Jose, CA, U.S.A.) according to manufacturer's specifications, with inserts and primers purchased from Integrated DNA Technologies (Coralville, IA, U.S.A).
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PMC11470381
Note: The imaging medium contains 25 mM HEPES (pH 7.5).
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PMC9429973
However, the lack of reduction in HSC function in wildling mice suggests that neonatal exposure and colonization of pathogens maintains HSC fitness in adults.
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PMC11742670
This endeavor involves evaluating a drug’s inhibitory concentration against a specific target molecule, a task with profound implications for pharmaceutical development.
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PMC11409031
Our research involved examining the potency of commonly used drugs by measuring their IC50 values in both high-risk and low-risk patient groups.
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PMC11222184
Table 1Gene symbols and descriptions in the qRT-PCR analysisSymbolDescriptionACLYATP citrate lyaseACSL4Acyl-CoA synthetase long-chain family member 4ADMAdrenomedullinANGPT1Angiopoietin 1ANGPT2Angiopoietin 2APAF1Apoptotic peptidase activating factor 1ARNTAryl hydrocarbon receptor nuclear translocatorATP5A1ATP synthase, ...
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PMC11594074
The DNMT1–compound 1 complex displays the highest range of RMSF values ranging from 0.38 Å to 4.17 Å, showing moderate flexibility.
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PMC3931643
Cells were treated with inhibitors for 4 hr and then washed with PBS and resuspended in methionine free RPMI 1640 media (Life Technologies) with 1% FBS for 1 hour.
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PMC10877303
The first two-thirds of the 5′ UTR of the MERS-CoV genome comprise the replicase complex, which includes ORF1a and ORF1b.
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PMC3164356
Transcripts with coverage <1× and length <200 bp were filtered out.
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PMC9919300
The intracellular ROS levels were detected using the cell-permeant 2′,7′-dichlorodihydrofluorescein diacetate (H2DCFDA) or dihydroethidium (DHE) (Molecular Probe, Life Technologies, Eugene, OR, USA) dye.
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PMC11488203
In particular, miR-212-3p is involved in the inhibition of different tumor types of the brain , suppression of ovarian cancer progression , and inhibition of bladder cancer .
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PMC9429973
NGS detected pathogenic mutations in JAK2 (p.Val617Phe, VAF 41%), SRSF2 (p.Pro95His, VAF 42%) and ETV6 (p.Arg105*, VAF 41%) and likely pathogenic mutation in ASXL1 (p.?;
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PMC11757230
Liang et al. showed that a human bone marrow fibroblastoid stromal cell line induces G0/G1 phase arrest and inhibits cell proliferation by regulating the expression of specific cell cycle-related genes in HL-60 cells.
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PMC11592837
After a final washing step with PBS, 25 µL of a cell suspension with 2 × 10 cells/mL in PBS were transferred to a silanized glass slide, cells were allowed to settle for 15 min, PBS was then carefully removed with a paper towel and cells were covered with 4′,6-diamidino-2-phenylindole (DAPI)-containing mounting medium ...
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PMC7887261
Further, the presence of additional rare deleterious variants, together with previously identified p.P1054R and p.L2307F, strongly suggests that the ATM gene plays a role in LC susceptibility.
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PMC11438317
After the final wash, the SN was removed.
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PMC11782508
Azurin concentration was measured using the Bradford assay and the A625/A280 ratio.
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PMC9444294
FISH indicates fluorescence in situ hybridization.
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PMC10820104
Despite breakthroughs in diagnostic tools, surgical treatments, and chemotherapy, the overall survival rates of PDAC remain low, and the only available therapies are classical chemotherapeutics with an unselective cytotoxic profile.
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PMC7961460
There are six different gene variants but only four of them express the protein (see Supplementary Table S1).
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PMC11711127
The authors showed that HINT1/Hsp70 treatment generated regulatory NK cells expressing GRAIL, indispensable for their inhibitory function.
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PMC11224020
The violin plot shows median values and quartiles (N = 2, n = 25 cells in si-Ctrl at 4 µm (80% of cells), n = 21 cells in si-cPLA2 at 4 µm (75% of cells), n = 16 cells in si-Ctrl at 3 µm (75% of cells), n = 16 cells in si-cPLA2 at 3 µm (76% of cells)).
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PMC11740573
The present study also showed that calcitriol (1,25-dihydroxy-vitamin D3) can be effective in enhancing antibiotic activity especially against GBS.
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PMC9429973
The frequency of JAK2, MPL and CALR mutations among PH patients was 78% (25/32),13% (4/32), and 6% (2/32).
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PMC11413393
Transcription levels for each type I enzyme were compared across our previously sequenced cell line models and PRMT1 was found to have the highest relative expression (Fig. 2a).
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PMC11754436
Total protein was extracted by whole cell lysis (KGP701; Nanjing KeyGen Biotech Co., Ltd.).
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PMC11633763
Statistical significance was set at p < 0.05.
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PMC11666785
The super-resolved image for corrSMLM is then reconstructed as shown in Fig. 2.
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PMC9429973
The protocol was authorized by the Ethics Committee of the institution and all subjects signed an informed consent.
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PMC9429973
Targets for MRD detection were identified by NGS of BM samples taken at diagnosis (Archer Myeloid Panel) covering 74 genes frequently mutated in myeloid disease.
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PMC11435360
Within the clinical setting, NMIBC is typically treated with transurethral resection of the bladder tumor followed by intravesical therapy.
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PMC8592717
Protocatechuic acid (PCA; 3,4-dihydroxy benzoic acid) and protocatechuic aldehyde (PAL; 3,4-dihydroxybenzaldehyde) are naturally occurring polyphenols found in vegetables, fruits, and herbs.
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PMC11637276
To avoid evaporation, PBS was added to each dish to keep in the incubator.
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PMC11087766
Regions of the picA gene to be targeted with guides were chosen based upon the AlphaFold2 prediction of the PicA structure (SI Appendix, Fig. S6).
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PMC9429973
Promyelocytic leukemia and secondary leukemia were excluded.
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PMC8662250
TEER (Ω/cm) = (Total resistance − blank resistance) (Ω) × Area (cm) To measure the permeability of cultured Caco‐2 monolayer in our experimental conditions, we measured the flux of FITC–dextran method (Wu et al., 2019).
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PMC11742670
Finally, the data set is gathered and saved in CSV files.
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