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OTAR3088
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BioData-CellLine_annotated

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PMC11682172
The identified proteins were sorted according to the significance levels following ANOVA testing.
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PMC11640476
Addressing these challenges not only contributes to the reliability of cytotoxicity results but also aligns with broader efforts within the scientific community to increase the consistency of pre-clinical research data .
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PMC11629143
Targeting dCas9 alone to a promoter can reduce transcription by sterically hindering the binding and progression of RNA polymerase .
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PMC9100622
The assessment of the effect of Atorvastatin and Simvastatin on cell proliferation and the IC50 determination were conducted by seeding, respectively, 5 × 10 A673, TC71, MCF7, A549, SKNSH, and KD, 7.5 × 10 POE, and 10 × 10 SKNMC in each well of 24-well plates.
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PMC11314247
Finally, HO-AAVPA decreased the percentage of living cells and increased cell apoptosis in SKBR3 cells with rates of 50.0% and 11.6% for early and late apoptosis, respectively (Figure 4).
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PMC11724582
Compared with those of the tumor cells in the NC-CM group, the number of colonies, migration, and invasion of the cells in the CAF-CM group increased at the same drug concentration (Fig. 3).
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PMC11765988
Despite its utility, MRI does not effectively distinguish between neoplasm subtypes.
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PMC11792740
Together, these mechanisms collectively contribute to the exhaustion and functional impairment of T cells, undermining the efficacy of antitumor immune responses.
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PMC11401350
Today, several genetic mouse models mimic Tfh PTCL/AITL in terms of clinical, pathological, histological, transcriptional, genetic and immunophenotypic features: they are based on the knockout of Tet2 and overexpression of RhoAG17V , based on Tet2 and IDH2 mutations and our transgenic mouse model is based on GAPDH over...
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PMC4685341
The cells were cultured under different selective conditions: (1) a combination of puromyin and MSX (2) only with puromycin, (3) only with MSX and (4) without selective pressure.
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PMC11453018
The binding region in LMNB1 comprises consecutive GGAA repeats (more than 14), which are associated with EWS::FLI1 transcriptional activation, while the binding site in P15 features a single GGAA motif that facilitates oncogene transcriptional repression (Fig. 6A).
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PMC3035438
After purification of the PCR products and cloning into the pCR2.1 TOPO vector (Invitrogen), 15 clones for IgL and 24 clones for IgH were sequenced using the M13 universal forward or reverse primers with an ABI 3730xl sequencer (Applied Biosystems).
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PMC10809689
Full-length blots/gels of b-actin, mTOR and GLS in the THP-1 cell line are presented in Supplementary Fig. 1 (b.), Fig. 2 (b.) and Fig. 3 (b.), respectively.
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PMC7351993
We directly dropped the sorted cells onto an agar plate, on which we identified 25 colonies after cultivation (Supplementary Fig. 8d), indicating the RIACS’ ability to sort a large number of cells without causing fatal damage to the cells.
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PMC11391695
Research has shown that ACYP is involved in numerous vital biological processes in vertebrates, including regulation of the glycolytic pathway, induction of apoptosis, and regulation of Na, K, and Ca ion transporters .
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PMC9693627
For this reason, we integrated the cDNA copy of PTCD2 open reading frame tagged with c-Myc epitope under the control of the tetracyclin-inducible promoter using the Sleeping Beauty transposon.
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PMC8540692
The results indicate that 48 h treatment with CCM did not demethylate the above-mentioned promoter.
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PMC11344246
Node weights were derived from variant score and edge weights from the differential network analysis.
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PMC8658661
According to their cytological characteristics, HepG2 cells are certainly the most similar to tumor cells in hepatoblastoma, but at the same time, they retain features characteristic of normal hepatocytes (see Table 2).
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PMC11547917
The cells were photographed for morphological changes at 100x magnification (Figure 2).
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PMC11512230
A particle needs to possess three key characteristics to be used as a delivery system.
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PMC11317131
Further studies are necessary to elucidate how these individual mutations improve activity.
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PMC9429973
24.34% of the patients had one comorbidity while 21.6% of the population had 3 or more.
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PMC9429973
At follow-up, there was a moderate negative correlation between longitudinal % change in the RANKL:OPG ratio and % change in DXA bone mineral density at femoral neck [r= -0.45, p<0.01].
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PMC5261804
Protein-protein interactions (PPIs) mediate the transmission and regulation of oncogenic signals that are essential to cellular proliferation and survival, and thus represent potential targets for anti-cancer therapeutic discovery.
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PMC10968586
However, HT triggers other molecular mechanisms that may influence HCC cell behavior besides affecting cell viability, at least in vitro.
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PMC11422497
It originates from the 3’-arm of the miR-494 precursor and is located on chromosome 12q32.
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PMC11653533
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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PMC11751675
All these results suggest the potential application of the pseudoguaianolides containing an α,β-unsaturated cyclopentenone moiety (e.g. brevilin A) in the treatment of influenza virus infection.
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PMC11451940
X-ray quality crystals were obtained from a THF solution layered with pentane and settled at room temperature.
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PMC11021472
SDS-PAGE was performed using 10% or 12% polyacrylamide gels and subsequent transfer onto nitrocellulose membranes was done as described previously.
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PMC9516447
Attempts to target mutant KRAS or its downstream signaling have been mostly unsuccessful, largely due to the molecular structure of the KRAS protein as well as compensatory upregulation of alternative oncogenic pathways .
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PMC11429241
The geometric properties of the scaffolds can be easily adjusted for the specific needs of 3D cell culture applications.
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PMC7215832
RX-3117 is a cytidine analog modified in the sugar.
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PMC11621493
Scale bar: 40 μm.
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PMC11258145
SK-N-SH and HL-60 cells were exposed for 24 h to various concentrations of curcumin (5–50 µM).
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PMC11462673
A Distribution of LDB1 binding to genomic regions in the 6 T-CEM cells, as assessed by CUT&Tag.
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PMC11348300
Nevertheless, these values offer valuable insights into the tissues probed by PRESTO in this study.
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PMC9621239
n = 3; Original magnification, ×400.
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PMC10998613
By comparison to monomer, dimer, and multimer membrane protein controls (31, 32), we could determine the oligomerization state of the protein (Fig. 2D).
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PMC9429973
WGS data were analyzed using a bioinformatic pipeline designed to call mutations in any of the 11 canonical U1 genes found in the human genome.
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PMC11747467
We then visualized the fluorescence intensity of pSTAT3 (Tyr705) under the randomly selected microscope fields (×800).
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PMC11597167
The p-value calculation employed was derived from a parametric, unpaired, two-sample equal variance, two-tailed distribution, a method that is widely recognized in the scientific literature.
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PMC11540664
All statistical tests were two-sided.
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PMC11569208
Further molecular analysis of our top hit, ACP2, confirmed its VSV∆51 enhancing activity and found that its mechanism of action hinges upon repression of IFN-1 signaling and its downstream antiviral effectors.
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PMC11748363
Therefore, the main objectives of this work were to investigate the influence of extending the retroamide linker by inserting the methylene group (V) and the influence of various substituents R and R (especially different positions of the ‐CF3 substituent, since in our previous work we explored 3‐CF3 only) on the antim...
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PMC11413393
Analysis conducted using Fisher’s exact test and PANTHER tool; number of genes in down regulated list per GO biological process listed above each respective bar.
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PMC11583010
In vivo efficacy of ETx-22 in SUM190 breast cancer cell line and PDX models.
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PMC11335267
To specifically address this question, we performed MRI on coronal planes and confirmed that the percentage of total fat mass relative to body weight was higher in Alx3-deficient mice (Fig. 1C and D).
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PMC5173112
Epigenetic regulation refers to heritable changes in gene expression that does not involve changes to the underlying DNA sequence [7–11].
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PMC11487720
A WWOXf cells, including DU145, HCT116, Wwox wild type MEF, COS7, Mv1Lu, and L929S cells, in 35-mm Petri dishes were exposed to UV (960 mJ/cm) and then subjected to time-lapse microscopy at 22 °C (200x; scale bar 50 µm).
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PMC9351137
Notably, mutations in genes encoding tubulins or functionally related proteins such as CIT-K and spastin trigger the onset of neurodevelopmental disorders, including microcephaly [60–63].
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PMC11036064
Cytoscape was used to have access to GeneMANIA and STRING datasets for studying the interactions between the studied genes (Shannon et al., 2003).
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PMC11344246
Therefore, this would be a valuable addition to future iterations of this pipeline.
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PMC11026382
Color coding follows from (c), the black dashed line indicates the distance distribution of all residues in the protein.
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PMC10490530
Substrate injection and BLI image acquisition protocol were the same as before using the IVIS Lumina II imaging system.
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PMC11481779
The first heatmap is raw model output - with no changes in the sequence.
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PMC8343815
On the other hand, megavoltage X-rays have been used clinically in the radiotherapy of cancer patients.
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PMC8864075
To explore reTFAE’s effects in the EMT process of lung cancer, A549 cells were treated with reTFAE (2, 4, and 8 μg/ml) for 24 h. Compared to 0 μg/ml reTFAE, the invasion rate of cells treated by reTFAE concentration-dependently decreased (Figure 1B).
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PMC11190538
In addition, acidity was tested according to the AOAC .
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PMC11240448
Thus, application of cSTAR requires either almost whole-proteome perturbation measurements, such as mass spectrometry phosphoproteomics, or careful supervised choice of ca.
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PMC11699178
Cell invasion was assessed under an inverted fluorescence microscope (Nikon TE2000, China), where 5 random fields were captured for each chamber, and the average number of cells passing through the chamber was calculated as representative of each group .
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PMC11126803
∗p <0.1, ∗∗p < 0.01.
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PMC3019555
Interestingly, we observed colocalization of the MBs with microtubules in untreated cells (Fig. 3 B).
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PMC9429973
Although the sample size was small, this is the first prospective study to show that eltrombopag is efficacious and has a favorable safety profile in a Chinese population with R/R SAA.
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PMC11531744
We found that targeted drugs were more significantly associated with gene expression patterns than conventional chemotherapy drugs.
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PMC9429973
It also associated with thrombotic complication and cytokine storm (IL-6), all these modification contributed in high rate of ICU admission V. Popov, L. Iliescu, A. Grigorie, C. Pirvu, O. Constantin, A. Badea, M. D. Badoiu Niculae, A. Rus, A. Calen, H. Bumbea, B. Mastalier, M. Andreescu Hematology, Colentina Hospital B...
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PMC11271278
The identities of the cell lines were verified by either SNP fingerprinting as previously described in the CCLE project or short tandem repeat analysis through IDEXX.
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PMC11711871
On a standard diet, mutant rats exhibited a trend toward increased corticosterone levels and a normal systolic blood pressure and heart rate but presented with adrenal hyperplasia.
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PMC11190238
The studies explore their involvement and events leading to the transcriptional activation of EMT-related genes during the EMT process.
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PMC9927933
Thus, it appears that DEPTOR has a rather complicated role in the regulation of growth and survival of cancer cells.
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PMC11720107
In the SCC-15 cell line, the Violeta garlic extract increased ROS production at concentrations of 0.250, 0.500, and 1.000 mg/mL, with significant increases of 41.5%, 135.0%, and 387.5%, respectively, compared with the control group (Figure 1K).
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PMC11075223
Meanwhile, it is stipulated that the content of IFA in the dry product shall not be less than 0.10%.
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PMC8414691
Thus, it might be possible that FHS patients also exhibit some predisposition for tumor development.
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PMC10237474
As in (D) but with protein 11 expressed from Expi293F GnTI stable pools.
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PMC10669966
Correlations between PDE3A expression and overall survival or metastasis-free survival were estimated with the Kaplan–Meier method and compared using the univariate Cox proportional hazard model.
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PMC9429973
Patient received Bortezomib 1.3mg/m subcutaneously on days 1,4,8 and 11 of a 21-day cycle (bi-weekly) or days 1,8,15 and 22 of a 35-day cycle (weekly).
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PMC11782508
The peak for α-protons of the cysteine residue (C112) is assigned at around 3.4 ppm (Fig. 5d); this residue is very close to the copper-binding site.
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PMC11543853
Nevertheless, our results demonstrate that N-WASP-mediated actin polymerization is important for the disruption of endosomes, which enables the delivery of enteroviruses into the cytoplasm.
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PMC10547921
The conformations of both α-tubulin and β-tubulin have changed, especially in helix H8 and H10.
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PMC10291556
In addition to the antitumor effect attributed to the inhibition of COX, DCF has also shown novel COX-independent effects caused by its influencing of glucose metabolism, particularly due to lactate transporter inhibition.
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PMC11023271
It may also allow for targeting of RIPK4 through a natural component of serum.
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PMC11792090
The lysates were then boiled and denatured before separation by SDS-PAGE.
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PMC7553912
Consistent with the expression patterns of these genes, Western blot analysis revealed that the protein expressions of OSM and OSMRβ were increased on days 3, 6, and 9 compared with those on day 0 (Fig. 1c–e).Figure 1Expressions of OSM and OSMRβ in the kidney of a mouse model of renal crystal formation.
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PMC8708099
Anti-inflammatory therapies, such as anti-TNF-α antibodies and steroids that regulate NFκB activation, are commonly used for IBD treatment, but are associated with side effects .
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PMC11765879
Additionally, morphological examination of our cell models after treatment supported the data obtained through cell viability by demonstrating clear signs of cell death.
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PMC7185206
Low PD-L1 protein-to-mRNA ratios predicted poor survival in adrenocortical adenoma, urothelial bladder cancer, breast cancer, papillary renal carcinoma, low grade glioma, hepatocellular carcinoma, and mesothelioma when controlling for age and tumor stage.
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PMC11098378
Although the specific role of SHOC2 during virus infection is unclear, it has recently been shown to activate ERK/STAT signaling in response to bacterial flagellin in shrimp hosts , implying that SHOC2 may indeed have conserved roles in combating bacterial and viral pathogens.
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PMC2614416
IC: Inferred by Curator, IDA: Inferred from Direct Assay, IEA: Inferred from Electronic Annotation, IEP: Inferred from Expression Pattern, IGC: Inferred from Genomic Context, IGI: Inferred from Genetic Interaction, IMP: Inferred from Mutant Phenotype, IPI: Inferred from Physical Interaction, ISS: Inferred from Sequence...
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PMC11106977
Fig. 5The role of O-GlcNAcylation modification in other bone-related diseasesO-GlcNAcylation also plays a role in other bone-related diseases, including OA (Osteoarthritis), osteolysis, bone metastasis and IDD (Intervertebral disc degeneration).
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PMC10253973
No Ru(II)/(III) compounds with anti-tumor activity have been commercialized.
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PMC11474209
For MC-LR monitoring in Freshwater, an electrochemical aptatoxisensor was designed by immobilizing a thiolated aptamer on the surfaces of a dendrimeric GCE|SDD-Co(II) nanostructure.
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PMC11762280
Importantly, UVB-induced epidermal thickening and keratinocyte death were alleviated in Zbp1 mice compared with WT mice according to the results of H&E staining and TUNEL staining assay (Fig. 6F).
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PMC9429973
Á. Otero Sobrino, J. Le Coq, P. Aguilar-Garrido, M. Á. Navarro Aguadero, M. I. Albarrán, J. Klett, C. Blanco, R. Fernández-Leiro, J. Martínez-López, M. Velasco H12O-CNIO Haematological Malignancies Clinical Research Unit; Electron Microscopy Unit; Biology Section; Genome Integrity and Structural Biology Group, Spanish ...
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PMC8623816
Previously, our laboratory isolated and characterized five dsRNA mycoviruses from the R. solani AG-1 IA.
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PMC11343332
This research investigates the multifaceted effects of pycnogenol on breast cancer cells, specifically focusing on its pro-apoptotic and anti-migrative properties through the modulation of p53/Bcl-2 and VEGF/FGF signaling pathways.
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PMC9910796
The ASFV genome is a 170–190 kbp long dsDNA molecule comprising more than 150 genes, about half of which encode virion proteins .
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PMC8609870
KEGG enrichment analysis mainly focused on the related signaling pathways.
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PMC11637284
The results of the TAC60 pulldown experiments showed that all three TAC60 mutants still interacted with mini-p166 (Fig 6B, 6C and 6D, middle panels).
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PMC10988555
To ensure the solubility of the complexes in all biological assays, complex solutions were freshly prepared and well solubilized before addition to the cells.
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