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PMC11243198
The chemical structure of BAS 07019774 was obtained from eMolecules (emolecules.com, accessed on 11 August 2023), and GANT61-D structure was as published previously .
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PMC9352806
We confirmed that the daf-16/hlh-30 mediated-lipophagy took effects in the process of BMS’ fat-lowering function.
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PMC9429973
M. Karimi, T. Zarei, S. Haghpanah, A. Azarkeivan, M. Naderi, S. Matin, A. Bazrafshan, Z. Zahedi, A. Shirkavand, P. Pishdad, V. De Sanctis Hematology Research Center, Shiraz University of Medical Sciences, Shiraz; Zafar Adult Thalassemia Clinic, Blood Transfusion Research Center, High Institute for Research and Educatio...
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PMC9429973
As shown in Figure 1, this initial search resulted in 721 entries, which were then further refined to include Phase III, Phase IV, and observational studies only, resulting in 236 studies.
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PMC9429973
One patient who was not treated with CPLZ in either HERCULES or post-HERCULES died as an outcome of recurrence.
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PMC6650823
On the other hand, the addition of a hydroxyl group adjacent to the epoxide ring of Cfz hindered the hydrolysis of the epoxide ring by inhibiting access to the active site of mEH.
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PMC11755467
For 5′ end labeled pre-miRNAs, the solution was heat inactivated for 5 min at 95 °C.
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PMC9780037
There is one additional biosensor in which trypsin is immobilized inside porous nanostructures.
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PMC8735881
It was found that GPI-anchored variable region (VHH) of CD4i-specific JM4 but not that of CD4bs-specific JM2 was able to render target cells resistant to both cell-free and cell-associated HIV-1 isolates, although two heavy chain-only llama antibodies displayed comparable anti-HIV activities in a soluble form , reveali...
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PMC11365427
l-Phenylalanine VIP and FC values are shown and meet the screening criteria. (
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PMC9429973
There was a significant statistical correlation between both groups of patients in regard to the grades of bleeding, the observed group showed grade I as the major type of bleeding while the treated group showed grade III as the major type of bleeding.
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PMC11240571
RT in combination with anti-PD-1/PD-L1 antibodies for carcinoma-bearing mice produced an abscopal effect that inhibited the growth of unirradiated tumors rechallenged on the opposite flank, suggesting the induction of a systemic, sustained anti-tumor immune response .
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PMC9646302
Western blotting and reverse transcription quantitative (RT-q) polymerase chain reaction (PCR) revealed that LAPTM5 expression was higher in the human ccRCC tumor group than that in the corresponding nontumor group.
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PMC11544122
Accordingly, when the same experiment was performed in the β-arr1/2 DKO cells, the BRET response did not change across all concentrations of CXCL12 for the 4 A variant, similar to the 5 A variant (Supplementary Fig. S8).
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PMC9812014
PV comes in three different variants and has an RNA genome and a protein capsid.
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PMC11201245
The authenticity of the cell lines was tested and confirmed using STR marker testing.
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PMC11676169
Depletion of BCAT1 accelerates c-NHEJ as determined by phosphorylation of DNA-PK (Figure 3C), which reaches similar levels as in the presence of BCAT1 but at a faster pace.
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PMC11001582
Fig. 3(GR)400 knock-in mice exhibit cortical hyperexcitability without neuronal loss.a, Representative image of the cortex (area delineated in yellow), enhanced magnification of the motor cortex (area delineated in green), and quantification of NeuN-positive (red) cell density in the whole cortex and in motor cortex in...
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PMC10900886
The inoculated plates were incubated at 33°C in 5% CO2.
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PMC9429973
She underwent induction and 2 cycles of consolidation with CPX-351.
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PMC11746948
Image in d, e shows representative results from three independent experiments.
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PMC10522430
This particular fungus features in pharmacological studies, gaining prominence within traditional Chinese medicine due to its attributed medicinal properties spanning anticancer, antidiabetic, antifibrotic, and anti-inflammatory effects [13–16].
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PMC11730320
D CXCR5 is selectively expressed by a subset of the Vδ1+ and Vδ1-Vδ2- γδ T cell populations.
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PMC11361748
Two-way ANOVA. (
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PMC11701801
When focused on SMARCB1, SMARCA4, SMARCA2, SS18, ARID1A, and PBRM1, SMARCB1 is included in four subcomplexes of cBAF and two subcomplexes of PBAF; both SMARCA4 and SMARCA2 are included in all subcomplexes; SS18 is included in four subcomplexes of cBAF and two subcomplexes of ncBAF; and SMARCB1, SMARCA4, SMARCA2, and SS...
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PMC10849234
When neutrophils are activated, the toxic granules are exocytosed, releasing a range of microbicidal products including proteases, lipases, and reactive chemical species, thus mediating pathogen attack and tissue damage, as well as amplifying inflammation [3–5].
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PMC3730428
IAPs are recognized as attractive targets for anticancer therapeutics.
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PMC10174970
Correlation coefficients between PAAD cell lines and primary tumor tissue.
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PMC11064533
The whole genome of the gene deletion mutants was extracted by Qiagen Cube using the Qiagen DNA extraction kit and was sent to Novogene, UK for whole-genome sequencing with Illumina NovaSeq 6000 (Illumina).
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PMC11726848
The emergence of giant cells may be associated with mitotic catastrophe or errors in the resolution of the radiation arrest of mitoses.
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PMC11701801
SWI/SNF chromatin remodeling complexes can be classified broadly into three subcomplexes: cBAF, PBAF, and ncBAF (Fig. 1G; ref.
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PMC11718109
Quantifications of individual vesicle size from the VMAT2-synapsin and synaptophysin-synapsin vesicle clusters are shown in dot plot (E) and frequency histogram (F).
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PMC11087766
DAPI stain is shown in blue, sfGFP in green, and mCherry in red.
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PMC11806106
The two constructs having the sYFP inserted after G267 showed the strongest agonist-induced change in FRET emission ratio with approximately 6% (Fig. 1B, D and Supplementary Fig. 1F), due to an increase in CFP- and a decrease of YFP-emission after agonist application (Supplementary Fig. 1G).
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PMC11759543
To detect the amount of reduced MTT, 200 μl of dimethyl sulfoxide was added, and the absorbance was measured at 540 nm using ELISA reader.
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PMC11541409
: p. 959-967.This reference is of importance because it reports that pimitespib is a promising drug for advanced GIST patients.
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PMC10854447
Table 2 displays the results as IC50 values.
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PMC9429973
It is however associated with development of therapy-related leukemia (t-AML/MDS) and the most frequent serious adverse events are hematological toxicities.
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PMC11683240
A and B, significance was tested using one-way ANOVA followed by Dunnett’s multiple comparison test and refers to controls treated with PT only (A) or untreated controls (Con) (B) (∗p < 0.1, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001, ns not significant).
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PMC5916734
A sufficient expression level of the auxiliary vkorc1 and PACE/furin genes can be ensured by cotransfecting the “compatible plasmids” with antibiotic resistance genes.
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PMC11512230
Here, we applied a new type of SP derived from virions and virus-like particles (VLP) of Alternanthera mosaic virus (AltMV) and well-studied SP from Tobacco mosaic virus (TMV).
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PMC11765879
The results showed a significant downregulation in the expression and the phosphorylation levels of the HER2 receptor in treated cells.
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PMC11611077
His-tagged prestin expression vectors were transfected into CHO cells and high-expression clones were obtained by drug selection and limiting dilution method.
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PMC7185206
ATZ-Alexa647-labeled 786-0-PDL1-GFP cells treated with DMSO vehicle or TAPI-2 were assayed for maintained surface PD-L1 (GFP/Alexa647+) by flow cytometry at 24 h. ATZ-Alexa647-labeled 786-0-PDL1-GFP cells treated with DMSO vehicle versus TAPI-2 were visualized for nuclei (DAPI, blue), C-terminus PD-L1 (PD-L1-GFP, green...
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PMC11754784
Scale bar: 50 nm.
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PMC9621239
Further, the distributions of haplotypes in the intra-patient tumour and non-tumour tissues were analysed.
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PMC11730000
When RA was co-administered with DOX, it increased the level of mTOR compared with DOX-treated cells.
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PMC9780037
This modification promotes selective recognition and endocytosis of the cyt c delivery system by these cells.
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PMC11650848
DNA and/or bisulfite-converted DNA was used for PCR reactions to amplify regions for multiple purposes.
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PMC3203927
Although statistically these cytokines can discriminate 2D from 3D effectively, they are not as a group necessarily the best candidates for 3D biomarkers.
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PMC11629192
After PE, the patient became seizure-free, but other symptoms persisted, and both serum and CSF anti-NMDAR antibody titer remained unchanged.
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PMC10777969
The numerical values presented in Table 1 are indicative of the better biological activity of thiadiazole and provide additional verification of our experimental results.
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PMC11746948
The percentage of dead cells was determined by dividing the number of SYTOX Green-positive cells by the total number of cells.
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PMC11686380
For cortical neurons isolated at E14, pCAG-GFP was also co-transfected to assess and assure the transfection efficiency.
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PMC11092382
These studies provide evidence that sophocarpine has cardioprotective effects on diverse forms of damage by mitigating inflammation, attenuating oxidative stress, and engaging multiple signaling pathways and mechanisms.
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PMC9429973
Results: Age itself proved to be an independent risk factor for survival: 6.9 months within the group of patients ≥ 65 years, 166 months in patients < 65 years (p < 0.001).
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PMC11388384
To measure the implied Deff, we calculated the slope of MSD over time at steady state and divided by 4, based on the relationship MSD(t) = 4Dt for diffusion in 2 dimensions.
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PMC8633974
Further analysis shows that stimulation led to up to 100 (JLat) to 300 (U1) fold increases in RNA production.
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PMC11746948
e Cell viability analysis in A375 cells pre-treated with ML348, ML349, Palm B, and ABHD957 for 24 h, followed by 48 h RSL3 treatment.
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PMC11742290
In an in vivo CRC study, doxorubicin-bound RSPO1-liposomes were more effective at lower concentrations than unbound doxorubicin .
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PMC11763111
Furthermore, upon stimulation with tumor antigens, LLT1 overexpression improved the anti-tumor efficacy (Fig.S4C).
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PMC11779876
Fig. 1TCR maturation and TRBC clonality in selected peripheral T cell lymphoma cases.a illustrates TRBC clonality in relation to the maturation stage of the lymphoma cell of origin.
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PMC11363012
While these 20 compounds represent only a small fraction of the natural product profile diversity of C. roseus, this analysis shows that all tissues have cells that specialize in monoterpene indole alkaloid accumulation.
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PMC11765988
Other miRNAs have been implicated in the pathogenesis of sarcoidosis and lymphoma.
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PMC9164404
The tumor volume was calculated following the equation below: tumor volume = 1/2 × LW, where “L” refers to the long diameter of the tumor and “W” means the short diameter of the tumor.
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PMC11534035
The PAI1 expression levels were manipulated by treating the cell lines with agonists and antagonists of the hypothesized upstream regulator of PAI1, GPER1.
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PMC5600151
Their structural properties and the fact that they can be almost precisely controllable during their synthesis are facts that support their application in the delivery field for cancer.
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PMC11615743
Mass spectrometry (MS) and denaturing‐PAGE confirmed the successful synthesis and high purity of the probes (Figures S1–S6, Supporting Information).
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PMC6468656
Recently, Aurora A was reported to associate with lymph node invasion in patients with breast cancer and renal cell carcinoma .
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PMC9841531
Strikingly, the lead compounds 24 (Figure 11C) and 30 (Figure 11D) had inhibitory potencies of 1.49 and 2.77 μM, respectively, in the daunorubicin assay while having a similar Imax compared to reference ABCB1 inhibitor 34.
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PMC11127909
B The binding of EFHD1 with ANT3 in 143B cells was analyzed by IP/IB, N = 3.
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PMC6442998
The study has been approved (DACE P2016-316) by the Institutional Medical Ethics Committee of Erasmus Hospital and Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium.
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PMC11155445
When acyl thioureas were used in combination with Lumacaftor (LUM), certain derivatives have the potential to boost the effectiveness of the approved modulator.
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PMC10813895
The lineage-specific expression in luminal epithelia decreases with age (Figure 1A).
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PMC11597291
Thus, intact non-degenerating cells may be visualized.
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PMC10669966
A combination of docetaxel and gemcitabine is another treatment option, with survival outcomes that are similar to those resulting from doxorubicin treatment .
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PMC11519583
Interestingly, it has been postulated that MPs are a significant source of Wnt ligands and can activate Wnt signaling via autocrine or paracrine machineries ; however, little is known about the possible role of Ror-family receptors in regulating MPs.
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PMC5839394
Culture dishes with stained colonies of a representative experiment; (B) Statistical results of colony-forming assays presented as percentage of colonies numbers in the respect of untreated cells used as control.
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PMC11266100
Additionally, we showed that sub-microsecond duration protocols reached higher, or on-par transfection efficiency and cell viability when compared to standard microsecond modality.
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PMC8567602
Statistical comparisons between two groups used two-tailed Student t test (unless a paired or heteroscedastic t test was needed and noted in the figure legend) and were performed in GraphPad Prism software 7.0; statistical significance was set at P < 0.05 or 0.01 as indicated in the figure legends.
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PMC10743717
The X-ray diffraction study on rat ABAD (17β-HSD10) revealed its tetramer structure .
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PMC11222184
Combining chemotherapy with HSP90 inhibitors and targeted drugs has the potential to efficiently prevent various carcinogenic signaling pathways while also increasing the anticancer benefits of targeted drugs.
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PMC7762347
It is a tricyclic alkaloid with a guanidine group linked to a hydroxymethyluracil group , and its zwitterionic character makes it a highly soluble compound in water (Figure 1b).
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PMC7433824
These agents can be easily reemployed for P4‐sensitization in GBM as their pharmacokinetics, therapeutic window, and toxicity levels are well established.
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PMC6889484
Round 6 replication kinetics.
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PMC10914904
TGF-β is required to regulate the production of immunoglobulin A (IgA) by stimulating B cells to control T cells.
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PMC11591030
A001-3-2), GPx (Cat.
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PMC11638255
Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article.
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PMC2614416
In addition, HepG2 proteome contains more Ontologies than normal human liver proteome.
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PMC7351993
Specifically, the array of the digitizers and FPGAs performs image acquisition of one or more cells (events) based on the 24-parallel four-color SRS image signals [represented by the data acquisition (DA) node array in Fig. 1 and Supplementary Fig. 4].
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PMC11412721
MEFs with the indicated genotypes were sequentially infected with pWZL-E1A12S and pBABE-Hrasv12 viruses as previously described (Toledo et al., 2006).
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PMC9847912
IC50 values for HIV-2 isolates ST, CDC77618, and 7312A, as well as SIVmac239, SIVmac251 and SIVagm.sab-2, could not be calculated because the level of infectious virus in culture wells that were dosed with the highest concentration of GSK232 used in the assay (40 nM) did not drop below 50% (relative to untreated contro...
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PMC10729469
Radioactivity was measured using combined positron emission tomography (PET/CT) (β-Cube, Molecubes Inc., Lexington, MA) at 0.5, 2, 4 and 6 h in the UNMC PET Core Facility.
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PMC11721064
It is well-established that STAT3 participates in cell proliferation, stem cell activation, and tissue regeneration through ligand binding and subsequent activation of various signaling pathways, including MEK/ERK, PI3K/Akt, and mTOR .
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PMC5363531
The level of luciferase in all five TS promoter clones showed how sequential treatments, consisting in 12 hours of maintained dasatinib followed by 72 hours of PEM, were able to almost abrogate TS promoter activity.
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PMC11607638
Sulfakinin receptor structural biology.
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PMC11359735
P. berghei sporozoites were metabolically labeled with [H]-palmitate coupled to fatty-acid free BSA for 12 h, washed, lysed, and CSP was immunoprecipitated.
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PMC11087055
G-H’’’) Trace of cell flow path of electroplated epiblast cells by using Imaris tracking analysis.
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PMC11638255
Transmigration was calculated as: (# cells migrated/400,000) × 100%.
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PMC7987994
During the suspension preparation, trypsin is used to detach cells growing on the surface of the cultivation plate.
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