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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
For the SjS patients, two out of the three abnormal clonotypes utilized the IGHV1-69/IGHJ4 or IGHV4-59/IGHJ5 rearrangements stereotypic for rheumatoid factors, which have previously been associated with MALT lymphoma development in SjS. Unbiased marker identification has yielded putative prediagnostic lymphoma markers ...
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PMC11746942
Nuclei were counterstained with DAPI (blue).
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PMC11397654
At the lower rim, two azide-functionalised arms were linked to the hydroxyl groups, then, CuAAC reaction with six propargylated isatin derivatives gave the desired compounds 42a–f. The triazole derivative 43 lacking isatin pharmacophore was prepared as well, using propargyl bromide in the last step.
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PMC9118379
The resulting target sequence database is called RefP_V. All of the sequences in RefP_V were reversed to generate decoy protein sequences, which were then concatenated with all of the target sequences for target–decoy searches to estimate the FDR for variant peptide identification.
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PMC10366908
Upon ligand binding to the extracellular domain of EGFR, the downstream signaling pathways, such as the mitogen-activated protein kinases, the phosphoinositide 3-kinase/Akt, the Janus kinase/signal transducer and activator of transcription, and the phospholipase C-γ/protein kinase C pathways are activated .
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PMC7553912
Crystal-binding molecules, such as OPN, ANXA1, and ANXA2, have been reported to be important for the crystal aggregation, crystal adhesion to RTECs, and crystal retention in renal tubules.
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PMC11407042
Check the cell digestion with a microscope.
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PMC9221284
However, the predictions that can be drawn from the primary structure of Trans4 and 5 are less clear.
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PMC11765678
Zhou et al. have shown that ER enhances cytotoxic effects of Docetaxel against ABCB1-expressing ovarian tumor cells by inhibiting efflux of the drug.
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PMC7961460
The enrichment in HA can be due also to cytokines and growth factors activity.
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PMC10197932
As housekeeping normalization protein, homemade antibody raised in rabbit against AGC (SLC25A12 aspartate/glutamate carrier) antibody which recognize both isoforms AGC1 and AGC2, was used as indicated in 31, 32.
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PMC11764090
SA may participate in cold resistance by regulating the activities of winter wheat (T. aestivum cv.
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PMC11747949
At the same time, CXCR1 receptor expression on 143B cells in mono‐culture increased significantly in hypoxia compared to normoxia (Figure 2F).
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PMC11588008
Phosphorylated ERK1/2 translocated from the cytoplasm to the nucleus, participating in various biological reactions such as cell proliferation and differentiation.
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PMC11774747
The small number of sorted cells required an additional expansion phase, and further research is urged to enrich for naive and memory cells, rather than the effector phenotype so far obtained.
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PMC11098378
These findings highlight the strength of our system for identifying pathogen-encoded modulators of key innate immunity pathways that are likely relevant to both bacterial and viral pathogens.
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PMC10587429
Ficoll-Paque PLUS Media (45-001-750, Fisher Scientific, Waltham, MA). -
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PMC11769516
One of the most potent mycotoxins is aflatoxin (AF).
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PMC9848491
Moreover, we also found that predictive features could predict the prognosis of UCEC patients regardless of clinicopathological factors.
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PMC11792888
p < 0.05 compared to the control (the culture media in absence of scorpion venom) from the ANOVA test.
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PMC10810426
To first examine interaction, we used a NIH3T3 cell line stably transfected with a CMV-driven gag/pol construct .
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PMC11592008
Upon activation by pathogens or stress signals, intracellular inflammasome complexes known as NOD-like receptors containing a pyrin domain (NLRPs) are formed, leading to caspase-1 activation.
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PMC9429973
Image: Summary/Conclusion: To sum up, the CLL microbiomes in comparison to healthy controls demonstrated lower enrichment of Lachnospiraceae and Ruminococcaceae families, the major SCFAs-producing bacterial taxa reported to have a protective effect against inflammation.
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PMC11271278
Data are presented as mean values ± SEM.
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PMC11791264
LC3B methylation was detected by using a dimethyl-lysine (ab7315) antibody and immunoprecipitated by using an anti-MYC antibody.
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PMC11594074
As a proof of principle, currently, two DNMTis, azacitidine and decitabine, have been approved by the FDA for treating acute myeloid leukemia (AML), as well as myelodysplastic syndrome (MDS) .
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PMC11291490
This signal is instrumental in immunoglobulin class switching, enhancing antibody affinity maturation, and priming CD8 T cells.
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PMC9776316
In the current study, we demonstrated that XRCC4-mediated NHEJ DNA damage repair also contributes to cisplatin resistance in ovarian cancer.
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PMC9429973
Baseline disease and CNS involvement did not appear to predispose pts to different efficacy results or treatment-related adverse events.
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PMC9386809
262 mg (89% yield); yellow solid mp 213–215 °C; H NMR (400 MHz, DMSO-d6): δ 1.09 (t, 3H, J = 7.1 Hz, CH3), 2.25 (s, 3H, CH3), 3.99 (q, 2H, J = 7.1 Hz, CH2), 5.14 (d, 1H, J = 3.3 Hz, CH), 7.26 (d, 2H, J = 8.6 Hz, Ar), 7.41 (d, 2H, J = 8.6 Hz, Ar), 7.80 (d, 1H, J = 2.9 Hz, NH), 9.28 (s, 1H, NH); C NMR (100 MHz, DMSO-d6):...
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PMC9817179
A four-state kinetic model was constructed in COPASI (Hoops et al., 2006) and interfaced using Python.
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PMC5839394
Doxorubicin hydrochloride (Sigma, st.
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PMC8740518
Chromatographic separation was achieved on a DB-5MS capillary column (30 m ×0.25 mm, 0.25 µm film thickness; J&W Scientific, Folsom, CA, USA).
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PMC11588008
Some of the above-prepared samples were taken with total GSH content for measurement.
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PMC9429973
Additionally, patients usually present decreased levels of serum Zn, which impact in the DDR is not completely understood.
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PMC9429973
Image: Summary/Conclusion: These results show that the fusion panel can be used in clinical diagnosis for the fusion transcripts in its scope, after testing on clinical specimens.
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PMC7709199
As a member of the class III receptor tyrosine kinases, colony-stimulating factor 1 receptor (CSF-1R) consists of an ectodomain comprising five Ig-like domains, a transmembrane helix and an intracellular kinase domain.
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PMC11279397
Certain viral infections have the potential to cause local and even global disruptions, posing substantial risks to public health.
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PMC10568263
MnO2 is widely adapted in biosensors, supercapacitors, and semiconductors, which has attracted huge attention.
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PMC11476837
Taken together, it seems that the modulation of the intracellular ROS level has the potential to break resistance to doxorubicin in an NRF2-dependent manner.
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PMC11665555
Finally, OXCT1-KO lines were derived from stable single cell clones.
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PMC9275501
It could inhibit tumor growth and prevent postoperative tumor recurrence and metastasis in breast tumor mouse models.
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PMC9429973
PET/CT examinations were acquired at baseline, mid-induction (after 4 cycles of treatment) and end of treatment (EOT).
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PMC10898159
The levels of methyltransferase-like 3 (METTL3) is elevated and confer to Imatinib resistance in GIST patients, because METTL3 mediate the mA modification on the 5’UTR of the multidrug transporter MRP1 mRNA, which facilitating MRP1 mRNA translation .
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PMC10443665
Tragacanthin could be promising to overcome the MTX resistance in ALL patients by enhancing the chemosensitivity of MTX through downregulating MDR1 gene expression.
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PMC11348300
Map illustrating reoxygenation rates following palpation in an ovarian xenograft tumor located on the leg of a nude mouse.
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PMC10366908
We determined the conformational epitopes of anti-human EGFR mAbs (EMab-51 and EMab-134) and anti-CD44 mAbs (C44Mab-5 and C44Mab-46) using the REMAP method.
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PMC9429973
Other mutations (e.g., EZH2, ASXL1, SF3B1, TP53) were present in 29%.
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PMC11566417
Each cell line was assessed at p10 and p20 for expression of commonly used markers to characterize bovine mammary stem/progenitor cell populations, at both the mRNA and protein levels.
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PMC11680982
Intriguingly, this finding aligns seamlessly with the retrospective MONALEESA study, where PAM50 analysis revealed that the clinical efficacy of CDK 4/6 inhibitors combined with endocrine therapy is not universally compromised in HR/HER2-low breast cancers, and subsets such as luminal B, HER2-enriched, and basic-like p...
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PMC11730305
Data are stated as mean ± SD.
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PMC10968586
In fact, treatment of MCF-7 and T47D cell lines with 100 μM OLE reversed hepatocyte growth factor (HGF)- and 3-methyladenine (3-MA, an autophagy inhibitor)-induced migration, upregulating LC3II/LC3I and Beclin1, while downregulating p62 .
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PMC9429973
Furthermore, the drug combination reduced leukemic burden in four patients with venetoclax-azacitidine refractory AML, who received gilteritinib and venetoclax as an individual treatment approach.
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PMC10940855
Cytospins were performed on RPMI 8226 multiple myeloma cells and processed for confocal imaging.
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PMC11626627
p < .05, **p < .01, ***p < .001, ns, not significant compared to the control.
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PMC8658661
The same mutation is characteristic for the HepG2 cell line , with suppression of the Wnt/β-catenin signaling pathway expectedly leading to apoptosis .
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PMC9275501
Some studies have not determined the optimal ratio of natural active ingredients and chemotherapy drugs, others had carried out to investigate on the optimal ratio of natural active ingredients and chemotherapy drugs by in vitro cell tests, but it is often difficult to obtain the optimal ratio in vivo.
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PMC11629143
The data suggest that histone acetylation influences transgene expression in this system more potently than the methylation of promoter DNA.
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PMC9780037
In other approaches, the specific binding of cyt c to an aptamer has been used for detection based on differential pulse voltammetry , surface-enhanced Raman scattering (SERS) , and fluorescence .
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PMC9504875
The isolated OTU domains have been reported to inhibit IFN induction .
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PMC8193046
To counteract this effect, we selected a virtual screening data set that favored ABCC1 inhibition as reported by us before .
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PMC7823217
Overexpression of these signaling factors fuels the progression of pancreatic cancer by enhancing cell proliferation, migration and invasion .
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PMC8143558
was the same as that of a 25 mg/mL concentration of Chloramphenicol .
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PMC2193049
As expected, lysis of untreated target cells was very low (Fig. 7 B).
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PMC10955424
Our results demonstrate the importance of OC ascites in promoting platinum chemoresistance and the potential of combination therapy to restore chemosensitivity of OC cells.
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PMC6160470
This assay measures two different modes: ATPase activation and ATPase inhibition.
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PMC8524093
At least two CHIKV interconnected transmission pathways take place: the sylvatic and the urban cycles.
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PMC9164404
The drugs were i.v.
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PMC9895440
To generate lentivirus, 2.5 million low passage HEK293T cells were cultured in DMEM medium and seeded into a 15 cm tissue-culture treated dish.
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PMC11723947
Human naive CD4 T cells were isolated from frozen PBMC using the EasySep Human Naive CD4 T Cell Isolation Kit II (Stemcell) according to the manufacturer’s instructions.
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PMC10196713
Data were analyzed using BellCurve for Excel (Social Survey Research Information Co., Ltd.).
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PMC5415764
Furthermore, P+T/iRGD LPNs statistically surpassed the combination of PTX NPs and free TET, which was in line with the cytotoxicity and apoptosis results above-mentioned.
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PMC11726183
All other aromatic protons can be seen in the range of 7–8 ppm.
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PMC7987994
The ISO standard recommends a cultivation medium supplemented with serum as an extraction medium because FBS enables the extraction of both polar and nonpolar compounds.
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PMC11045125
The new model system described here may also be useful for studying an unusual type of human malignancy described by the WHO as “Burkitt lymphoma/leukemia with IG-MYC rearrangement displaying a B-cell precursor immunophenotype”.
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PMC11803210
Processing of data, included the following modifications: Sequencing reads with low-quality, adaptor-polluted and high content of unknown base (N) reads, were removed prior to additional analyses.
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PMC7802142
a Fluorescent images of DPCs incubated with tdTomato-labeled ReN-NV (red) for 3 h, 6 h, 12 h, and 24 h, respectively.
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PMC11697703
Future studies could address this limitation by analyzing large cortical regions at high resolution to reconstruct layer V dendritic arbors under different miR and MAPK8 expression conditions.
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PMC10203589
Expression of FGF18 and four FGFR genes was detected in 12 normal melanoma cell lines (NM) and melanoma cell lines by RT-PCR.
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PMC9926039
The A549 cells were stimulated with 5 and 20 μM methadone as well as 20 and 40 μM naloxone for 24 h. The total RNA was extracted from the treated cells using RNA mini Kit (Total RNA Prep Kit, Bio FACT, South Korea) according to manufacturer instructions.
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PMC11679892
Then, control and dose groups were adjusted.
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PMC11597291
Recently, GO family nanomaterials have been intensively investigated as drug delivery systems (DDS) in combination with tumor-targeting peptides and folic acid (FA) molecules , metal and metal oxide nanoparticles , and aptamers , as well as in combination therapies, such as photothermal/photodynamic therapy and hyperth...
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PMC9545474
Cells were analysed in a BD Accuri C6 Plus System Flow Cytometer using Ex/Em: 490/525 nm for the oxidative stress detection.
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PMC10094992
In conclusion, our findings present ALDH1A3 as an attractive target for the therapeutic management of MPM.
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PMC8140214
Cell culture and treatment The human HepG2 cell line was acquired from the National Cell Bank of Iran (NCBI, Pasteur Institute, Tehran).
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PMC11258145
Different letters indicate significant differences: for the SK-N-SH cell line uppercase; for the HL-60 cell line lowercase letters.
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PMC9429973
Image: Summary/Conclusion: Our study showed differences in the abundance levels of gut microbiota both on the progression and the response of the MM disease.
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PMC11591038
The immune system includes innate and adaptive components that can function efficiently through various immune-related cells such as dendritic cells, macrophages, neutrophils, B cells, and T cells.
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PMC6461034
Third, to assess performance of INKA analysis in a preclinical model with clear‐cut biological effects, we analyzed published phosphoproteome data (Bensimon et al, 2010) of human G361 melanoma cells after induction of genotoxic stress with neocarzinostatin, a radiomimetic that induces double‐strand breaks (Fig 5E and F...
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PMC9429973
Primary and Post-PV/ET MF comprised the majority of the study population (93% [79/85]).
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PMC9143157
Above-described cells of 5 × 10 cells/well cells were seeded in 12-well plates and treated with 100 μg/mL (THP equivalent) of P-THP or THP for the indicated time periods.
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PMC8469018
All reagents, standards, and samples were prepared according to manufacturer instructions.
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PMC11742290
Overexpression of LGR5 promoted HCC cell viability and enhanced colony formation .
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PMC11742290
Inflammation and hypoxia in tumor tissue microenvironment can also potentially inhibit LGR5 protein expression through post-translational mechanisms .
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PMC10955424
Our findings demonstrated the importance of OC ascites in promoting platinum chemoresistance as well as the potential of combination therapy including JAK, c-MET inhibitors and 2HE2 in restoring platinum chemosensitivity to OC cells.
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PMC11740207
Studies have shown that disruptions in the balance between SDs and ADs can lead to malignant progression, as the regulation of differentiation and apoptosis is compromised.
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PMC7081114
Three days later, the cells were seeded into 96-well plates at a density of 2000 cells/well.
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PMC11655536
Cells were treated with HA at indicated concentration for 48 h. G The IC50 of HA on cell viability in RPMI-8226, U266, MM.1S and ARH-77 cell lines.
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PMC11055510
Five candidate target genes were identified: hepatocyte growth factor (HGF), prolactin receptor (PRLR), protein phosphatase 2 regulatory subunit Bbeta (PPP2R2B), IL1RAP, p21 (RAC1) activated kinase 3 (PAK3) (Fig. 6B).
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PMC11036064
Although substantial advances have been made in our understanding of GBM biology, the prognosis of affected patients is still unfavorable.
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