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OTAR3088
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BioData-CellLine_annotated

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PMC11697065
Data displayed by combining D0 and D6 (A) or displayed independently of day in culture (B).
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PMC11622247
In stark contrast, probes C6-2AF568-QB and C7-2AF568-QB (Fig. 3A) showed exceptional brightness of up to 179 000 M cm (Table S4†).
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PMC10745221
Reactions were terminated with 5X sample buffer, and 30 μL of the reaction were fractionated with SDS-PAGE as described above.
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PMC9429973
An ESA was used in 56% (n = 190) of patients, of whom 38% received red blood cell (RBC) transfusions during ESA treatment.
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PMC11748335
The two-tailed t-test was used (***p < 0.001, **p < 0.01, *p < 0.05, NS.
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PMC11577421
Figure 2B further indicated that the binding affinity was enhanced when the pH was below 7.4.
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PMC9429973
Median OS follow-up duration was 11.1 mo for gilteritinib and 6.9 mo for SC.
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PMC9429973
To answer this question, we investigated somatic myeloid mutations, also called clonal hematopoiesis (CH), in sequential blood and bone marrow samples from patients with MCL treated with Lenalidomide-Ibrutinib-Rituximab on the Nordic Lymphoma Group (NLG) Philemon trial (NCT02460276).
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PMC11694346
Following this, we conducted fluorescence imaging experiments using A431 cells to evaluate the practical applicability of BT-DNBS for live-cell imaging.
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PMC9429973
AID expression was low and at comparable levels in both LSR-Low and LSR-High CLLs.
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PMC9429973
SASH3 is an X-chromosomal encoded adaptor protein that is exclusively expressed in lymphocytes.
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PMC11742431
After 48 h of treatment, fluorescent inverted microscopy (Figure 1C), fluorescence microplate reader detection (Figure 1D), flow cytometry assay (Figure 1E), and western‐blot analysis (Figure 1F) were performed.
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PMC11361748
Data are shown as mean ± SEM.
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PMC11637276
The Z-factor (Z’) provides insight into the quality of a high-throughput assay (where 1.0 > Z ≥ 0.5 indicates an excellent assay and 0.5 > Z > 0 is considered a marginal assay) .
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PMC11766174
The sensitivity of CA-ICC was first evaluated with MOLT IIIB cells, a human T-cell line chronically infected with HIV that constitutively produces HIV proteins in the cell and virus particles in the culture supernatant , and with in vitro infected human PBMCs (Figure 1).
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PMC11757131
Valine is a branched-chain amino acid that produces various intermediate products during metabolic processes in organisms (9).
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PMC11806818
Table 1Single-mode aptamer biosensors based on nanozymes for circulating tumor cell detectionCell LineAptamerNanozymeSubstrateDetection MethodElectrodeLinear RangeLODRecovery(RSD)Assay TimeRef.
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PMC9436459
The IC50 values of 58 to the tested strains HSV-1 (15,577), HSV-1 (clinical), and HSV-2 (333) were 2.2, 1.5 and 2.5 μg/mL, respectively.
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PMC9412887
Yu et al. constructed a weak acid-activated, charge-reversible, triphenylphosphonium (TPP)-based, “shell–core” nanosystem (DOX-PLGA/CPT/PD) for sequential facilitation of tumor accumulation, cellular uptake, mitochondria targeting, intracellular localization and surmounting drug resistance of MCF-7/ADR breast cancer (F...
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PMC11317131
n = 4.
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PMC6889484
Importantly, the in vitro experiments indicated that selection for A3G-D128K-resistant HIV-1 variants has a high genetic barrier, adding further support to potential anti-HIV gene therapy by the expression of A3G-D128K to control HIV-1 replication and spread.
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PMC11594074
ß-Actin is a vital part of the cytoskeleton that modulates a plethora of essential cellular processes, including migration, cell division, and gene expression regulation .
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PMC11609529
A positive Z score indicates activation, while a negative Z score denotes inhibition. (
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PMC11549612
P<0.05.
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PMC7215722
An impaired function of the ER under stress could influence the trafficking kinetics of proteins from the ER to the Golgi.
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PMC11635087
Scale bar, 2 μm. (
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PMC11344246
In the last 30 years, structure-based drug design has revolutionised the pharmaceutical industry.
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PMC9429973
K. Garzón, E. Fernández, K. Bermúdez Instituto Nacional de Cancerologia, México city; Private Practice, Mexico city, Mexico Background: High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) is a consolidation treatment for several hematologic malignancies such as multiple myeloma (MM), Hodgkin ...
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PMC6771295
Image J was used for quantification.
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PMC11201245
This malignant form plays an essential role in both metastasis and various forms of chemoresistance; the detailed and presumably interconnected processes are part of current research .
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PMC10212663
The Kyoto Encyclopedia of Genes and Genomes enrichment analysis suggested that advanced KRAS‐mt LUAD are enriched for adhesion‐related pathways, especially for the cell adhesion molecules, whereas the KRAS‐wt ones are not (a)–(c).
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PMC9429973
In a selected group of patients with all required bone marrow and lab values to derive ELN response (n=435), the ORR (95% confidence interval) was 80.5% (76.4, 84.1) for derived responders and 79.1% (75, 82.8) for physician-assessed responders.
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PMC11635519
PepA3 and its two related variants PepA and PepA2 stimulated the GLP-1R with lesser potency but the same efficacy as that of GLP-1.
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PMC11705547
Effect of cisplatin on the TIME. (
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PMC10938336
For the STITCH database, targets with a combined score greater than or equal to 0.7 were selected for further analysis.
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PMC10820104
1–7).
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PMC10253553
The premise for this line of investigation stemmed from protein array results showing that this phosphorylation mark showed the greatest fold increase in ccRCC relative to pair-matched non-cancerous renal tissue (Table 1).
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PMC11574271
J Hematoxylin and eosin (H&E) staining was performed to detect metastatic livers. (
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PMC11726848
It is important to note that after irradiation at a dose >D37, a decrease in the number of cells in culture was observed already 24 h after irradiation both under the HDR and LDR regimes.
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PMC10094992
NR6 treatment significantly reduced neutrophils infiltration in MSTO-211H MCSs.
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PMC9429973
Aims: To assess the prevalence and severity of treatment and disease complications, capture disease management, and identify predictors of complications in a representative sample of patients with transfusion-dependent β-thal in routine settings in Greece.
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PMC11721587
The cytoplasmic and nuclear fraction of Cl8 cells were firstly incubated with Ci antibody (2A1, DSHB)/Protein G beads and then eluted with GST Ci 700 to 850 fragment (1 μg/μl) (antigen of Ci 2A1 antibody, expressed and purified from BL21 E. coli cells) in buffer containing 20 mM bis-tris (pH 7.0) and 50 mM NaCl.
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PMC9386809
After several experiments, when metathesis was carried out with ZrCl4(THF)2 in toluene at 110 °C, complex 2 could be afforded in a 76% yield (Scheme 1).
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PMC11748335
To explore the association between PMD length and long LOCKs, we categorized common PMDs into three subsets (S/I/L-PMDs) based on a published method (Fig. S2D-E) .
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PMC11708541
Additionally, they demonstrated that the MPTP-induced rise in malonaldehyde (MDA) and drop in superoxide dismutase (SOD) levels could be considerably mitigated by 4AP therapy.
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PMC11363012
To more accurately assess the ratio of compounds produced in each cell across the entire cell population that was measured, we used these quantitative data to generate stacked plots to show the absolute levels (mM) of each of the 16 quantified compounds in each cell (Figures 5a and S16b, S17, S20, and S21).
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PMC9429973
BMP2 and 6 bind BMP receptors, including ALK2, to phosphorylate SMAD1/5/9, while IL-6 signals through STAT3.
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PMC11222184
5Changes in the expression of heat shock proteins (Hsp27, HSP70, HSP90) in SH-SY-5Y cells after a 48 h treatment with XL-888 and Debio0932.
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PMC11727062
According to (Li et al. 2019), toadflax endolipids, when acting on human malignant melanoma A375 cells, modulate the AKT signaling pathway and its downstream proteins, such as mTOR, p70S6K, GSK-3β, and CyclinD1.
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PMC10204952
Thus, we undertook a transcriptome study of the differentiated SGBS adipocytes treated with 100 nM S1P .
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PMC11026382
In particular, we obtained a regime of DHFR kcat and Km values that is sufficient to support growth for each TYMS mutation.
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PMC7171147
Scale bar 100 µm.
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PMC10957991
Loss of TRPV4 from the mammary epithelial cell populations subsequently leads to disrupted mechanical features and impaired 2D and 3D mammary epithelial structures.
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PMC5925824
Panel a: Jurkat-NFAT reporter assay: Each data point represents the average of two technical replicates, with error bars representing the SD.
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PMC9712534
Representative images of FRAP analysis of EGFP-TOP2B H58Y in the presence of ICRF-187.
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PMC11204465
AFB1 is a precursor of OMST, and the hypD gene encodes integral membrane proteins that are essential to produce AF B1 and AF G1 .
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PMC10994876
Statistical analysis between groups was assessed using one-way or two-way ANOVA.
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PMC10578720
White arrows indicated doubly stained cells.
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PMC8524093
A CHIKV-infected 17-year-old rhesus macaques showed significant differences in viremia, clinical symptoms, and the CHIKV-specific immune response compared to adult rhesus macaques with 6–13 years old.
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PMC6600253
Tippani et al. first performed molecular docking studies to evaluate the interaction between PT and the active site of telomerase .
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PMC11228511
We have never observed loss of intimal endothelial cells or adventitial mesenchymal cells even though the intima and adventitia are also exposed to mechanical stress.
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PMC11686380
Growth-associated protein 43 (GAP43), also known as F1, B-50, Basp2 and neuromodulin, is a membrane-associated phosphoprotein predominantly expressed in the nervous systems.
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PMC11286266
Transduction of the XC45-6S ATF6α/IRE1 dual UPR reporter cells was performed at a coverage of ~640×, with a multiplicity of infection (MOI) of 0.3, intentionally set low to disfavour acquisition of more than one sgRNA by any one cell (Shalem et al., 2014).
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PMC9429973
In AML-loaded humanized mice, treatment with BMP2 induced the occurrence of BMP2-Vδ2 cells and reduced the survival rate of mice.
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PMC11185260
Serum samples from mice treated with radiation in combination with cisplatin showed significantly elevated levels of alanine transaminase (ALT, 2.2-fold increase) and aspartate aminotransferase (AST, 3.0-fold increase), two key liver enzymes indicative of hepatocellular injury, compared to the baseline levels in the se...
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PMC11575040
That study also indicated that HCG11 was a promising target for the effective treatment of patients with ovarian cancer.
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PMC11721587
The N- and C-terminal Fu phosphorylation sites on Ci (S218 and S1382) are located within or close to the N- and C-terminal Sufu-binding domains, respectively (fig. S2C) (23, 29), raising the possibility that Sufu binding could mask these sites.
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PMC11342785
B, representative images pre- and post- 5 min blue light activation for optical clustering of TPPP-CORE and the C-terminally IDR containing variant C-CORE in NIH3T3 cells (SiR-tubulin, green; Hoechst, blue).
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PMC9429973
In patients with normal day 100 FLCr, median OS was NR vs. 12.8 years, respectively (P=0.10) Figure 1b.
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PMC9014716
MiR-224-5p was highly expressed in tumor tissue compared with normal tissue in patients with HCC in TCGA database (N.T. means normal tissues; T.T. means tumor tissues). (
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PMC2777936
FZD1, FZD3 and FZD6 were each significantly up-regulated following RA-treatment and FZD5 was significantly down-regulated.
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PMC10522430
G. applanatum specimens were sourced from Tulungagung, East Java, Indonesia.
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PMC8164677
Tested compound came out as a stronger ligand for Nrf2 than standard drug trigonelline with low binding energy (−10 Kcal/mol) than standard (−6.3 Kcal/mol), however the possible reason can be the formation of an additional pi-pi bond or absence of Pi-anion bond which is present in the case of standard inhibitor (Figure...
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PMC9429973
The HFE mutations could facilitate the increase in red cell mass, and this indicates the possible involvement of Iron Metabolism in causes of IE.
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PMC7987994
Three replicates 1–3 were used.
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PMC8873393
We find that the bulk of mRNAs recovered from the stalled RNAP II are relatively short, suggesting a pervasive mechanism of UV-induced specific transcription elongation.
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PMC10933092
However, there was no difference in the sites of mA modifications between sh-NC and sh-TRMT61A cells, as the percentage of mA modifications at different regions of mRNAs (5′-UTR, start codon, CDS, stop C, and 3′-UTR regions) and lncRNAs remained the same with or without TRMT61A knockdown (Figure 3D).
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PMC11782780
Furthermore, Lu et al. revealed that miR-301b-3p facilitates BC occurrence and development through the targeting of HOXA5.
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PMC10530622
Overall, this study pointed out a mechanistic explanation for the higher risk of kidney stone disease in NAFLD patients .
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PMC3203927
Two are down-regulated both in 3D and NS.
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PMC11514418
In addition to GS chemotherapy, APS injection (Tianjin Sainuo Pharmaceutical Co., Ltd.) was given to patients in necessity after the GS chemotherapy.
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PMC8592717
As they are redox-active with a short life span and are sacrificed when they act on the ROS, they need to be regenerated to curtail the ROS levels.
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PMC11345828
Following the automated staining run, the slides were washed in a mild detergent, then thoroughly rinsed in distilled water, put in a 90% ethanol bath for 1 min, then moved to three baths of 100% ethanol for 1 min, then moved to two baths of xylene for 30 s, and finally coverslipped with mounting medium.
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PMC5874706
Experiments were conducted in triplicate.
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PMC11395280
Since trans-endothelial migration employs β1 and β2 integrins, it was unclear which integrin was inhibited by CCL198-83.
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PMC11001582
Image analysis was performed with Suite2p (ref. )
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PMC11266100
The luminescence of established tumors was imaged by IVIS Spectrum and Living Image Software (Caliper/Perkin Elmer, Akron, OH, United States) when tumor volume reached 50 mm.
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PMC11045125
A GFP/G418R cassette was inserted into the non-essential BXLF1 gene of the AG876 type 2 EBV strain genome in the AG876 BL cell line by homologous recombination using G418 selection, and then stably infected HeLa cell clones containing this virus were derived as previously described .
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PMC11676670
We established the OVAR79 ovarian cancer cell line originating from ascites of a patient who was clinically diagnosed with high-grade serous ovarian carcinoma (HGSOC).
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PMC10969097
Screening: JF and SR independently analysed the titles and abstracts of the studies, applied the eligibility criteria, and all irrelevant studies were excluded.
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PMC9429973
All primary and key secondary endpoints were met (Table).
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PMC11429241
The advantages of TPP are well understood, resulting in the technology having been applied in a plethora of fields .
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PMC11025866
However, valproic acid (VPA), another HDAC inhibitor, does not induce the EBV lytic cycle in Burkitt lymphoma cells .
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PMC7305184
In 15 generations of cell line, spread over the course of 2 months, we did not succeed in developing electroporation resistant cells line.
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PMC6267596
For RNA-Seq analysis, U2932 cells were treated with 50nM alisertib and DMSO as a control.
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PMC11320834
The BRCA1/2 mutation status analysis was performed using NGS (next-generation sequencing) for all primary cell lines listed above.
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PMC11653533
F. religiosa, despite being known as an aboriginal Indian tree, is generally local to the Asian tropical ranges, including Bangladesh, India, Nepal, Pakistan, China, Myanmar, Thailand, Vietnam, and Iraq.
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PMC9454852
BOLD-100 is a specific modulator of GRP78 and we have observed that it shows cytotoxicity against MPM cells.
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PMC9927933
The mice were intratracheally administered Ad-Cre to only activate Kras [Kras(+)Ube2c or Kras(+)Ube2c, WT control group] or to simultaneously activate Kras and inactivate Ube2c [Kras(+)Ube2c, experimental group].
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PMC11055443
IL-6 (A) and PGE2 (B) production in 48h supernatants of secretome (Sec) treated Caco-2 in response to Vibrio cholerae The PGE2 production from Caco-2 cells was 101.4 ± 18.97 pg/mL and reached to 121.1 ± 19.95 pg/mL in treatment with V. cholerae (P = 0.07).
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