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OTAR3088
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BioData-CellLine_annotated

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PMC11670407
Briefly, cells in the exponential phase of growth were harvested and seeded in a 6-well plate.
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PMC11541409
Journal of Clinical Oncology, 2022.
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PMC11742231
For instance, the random forest algorithm’s main limitations include over-fitting and the limited information derived from genomic data alone.
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PMC10907726
Diallyl trisulfide (DATS), a compound derived from garlic, has been demonstrated its anti-cancer properties.
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PMC11568601
A microplate reader was also utilized to determine the purity and quantity of the extracted RNA.
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PMC9429973
For variant detection, we used a custom-made targeted next-generation sequencing panel covering 226 genes known to be mutated in inherited cytopenias followed, if needed, by whole exome sequencing.
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PMC9429973
Results: Twenty-nine patients were included in analysis (median age 53.4 years).
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PMC11799620
Figures 8 and 9 show the ability of OFAE extract to protect HepG2 cells and HEK293.
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PMC9429973
Aims: To study epidemiology and evaluate the results of the treatment of HL in patients with HIV in national multicenter study.
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PMC4355729
The T7 promoter was added upstream of the Cas9 sequence.
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PMC3203927
Another recurrent gene function theme in Table 3 is terminal differentiation, a process by which cells commit to being part of a particular tissue or organ and perform a particular function.
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PMC7723249
Twenty-four hours post infection (hpi) cells were fixed by glacial methanol/aceton (1:1) over-night.
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PMC11740573
Calcitriol, which like other active vitamin D compounds is lipophilic, has a significant modulatory effect on antibiotic activity.
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PMC7553912
We also investigated crystal formation, inflammatory status, and the expression of crystal-binding molecules in the kidney of OSMRβ-deficient (OSMRβ) mice.
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PMC9895440
gRNA sequencing reads retrieved from this sequencing were demultiplexed and uploaded to PinAPL-py.ucsd.edu.
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PMC11727638
This study aimed to develop a hemispherical 3D lymphoma model utilizing the Cell Dome system and to evaluate the lymphoma-derived cells.
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PMC10907726
The phosphatidylinositol 3-kinase (PI3K) family of enzymes are involved in several cellular functions, including cell growth, proliferation, movement, differentiation and intracellular transport.
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PMC10852540
After the incubation, the media in the wells were completely removed, and 200 μL of ultrapure DMSO (Merk, United States of America) was added to each well and left in the incubator in the dark for 2-4 hours.
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PMC11756907
GO (in EtOH or DMSO, respectively) and 2-ME solutions were combined at a volume ratio of 1:1.
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PMC9429973
CLL with mutated IGHV expressed higher levels of activated VLA-4 compared to unmutated IGHV CLL (p=0.001).
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PMC11683240
The most probable binding conformation was proposed based on the analysis of RMSD, buried surface area (BSA), and Gibbs energy.
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PMC7185206
Survival analysis was performed by Cox proportional hazards modeling and all data were right censored for analysis.
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PMC11257988
PI3K also activates the monomeric GTPase RAC involved in mitogen-activated protein kinase/extracellular signal-regulated kinase (MEK1 and 2) and catalyzes cell migration.
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PMC9684669
Notably, neither H1R nor hERG inhibitors were able to duplicate the synergistic effects of terfenadine on the MDR cancer cells, indicating that other biological mechanisms may be involved in the reversal of chemosensitivity.
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PMC11033180
Figure 2Sema3A and its receptor Plexin A1 and Plexin A2 are expressed in enteric neurons in the rat distal colon(A, A′, B, and B′) Triple immunolabeling for Sema5A (green), Hu (marker of neuronal soma, red), and β3-tubulin (marker of neuronal soma and axonal processes, blue) in the myenteric plexus of rat distal colon....
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PMC5311252
No. 3894), which was then dried in a SpeedVac.
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PMC8632470
IC50 was calculated using GraphPad Prism 8.0.2.
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PMC5941560
Affymetrix SNP6.0 array genotypes and Pindel variant calls for the Jurkat cell line (sample ID: 998184) were downloaded from the COSMIC Cell Line Project SFTP site (/files/grch37/cell_lines/v78/).
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PMC11594074
Afterward, 100 µL of developing solution was added to each well and incubated at RT for 5 min in the dark.
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PMC11451940
The entire process was conducted across three independent experiments, each with duplicate samples.
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PMC4270159
Load 16 µl of sample (25–30 µg/lane) in each well of the Tris–glycine gel.e.
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PMC8759873
The homologous VHL has also been identified in mice, worms, and fruit flies .
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PMC9429973
Our study suggests that patients with at least 4 years of remission after a frontline auto-HCT and who achieved at least a VGPR after KRd induction, benefit the most from this treatment strategy.
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PMC10831439
α-GalCer seemed to boost TNF-α release by both effector cells.
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PMC11291490
Therefore, we speculated that dusCD40L, much like its mammalian counterpart CD40L, possesses the capability to enhance adaptive immune responses.
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PMC6133382
A total of 166 colonies were expanded to 24-well plates: 55 from the target 1 pool, 67 from the target 2 pool, and 44 from the combined target 2 and 3 pools.
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PMC11711127
Evidence suggests 25%–40% of T cells reactive to a single self-epitope escape central tolerance (1).
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PMC3035438
Surface IgM-positive and -negative populations were determined in each culture by the same method as in Figure 1a.
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PMC11802929
This leads to single cells with matching transcriptomics and surface protein data (which is the data for plotting main Fig. 7a–c, Supplementary Fig. 6c, Supplementary Fig. 9d).
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PMC11670407
Tissue samples were collected from six patients with osteosarcoma diagnosed at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China, between August 2020 and August 2023.
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PMC7582629
Raman imaging alone does not allow live, high-resolution imaging of large areas in complex matrices, for instance in tissues, where the cells and extracellular matrix coexist and interact.
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PMC11629192
Considering its better tolerance, fewer side effects, and independence from plasma availability, IA is also used as a viable option for severe patients in clinical practice to address plasma shortages and reduce the potential complications associated with PE [, , ].
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PMC11576293
Finally, the Abbott bioavailability score (F) was found above zero for all test compounds.
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PMC9024365
This effect is accentuated when AMPAR puncta are stratified for co-localization with SD4, resulting in a 100 and 65% increase in GluA1 and GluA2 puncta, respectively.
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PMC11513571
Mann–Whitney U-test was used, and the data are presented as the median (25th-75th percentile).
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PMC11544122
Data represent the mean ± SEM from six independent experiments.
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PMC11674834
In this study, we examined γ-H2AX generation induced by 3,4-DMA using an in-cell Western assay.
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PMC10669966
Cell viabilities were measured with CellTiter-Glo Luminescent Cell Viability Assay (Cat.
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PMC11740207
In 2023, provided evidence that CSCs arise from oncogenically transformed VSELSCs (Bhartiya et al., 2023b).
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PMC11240052
Primer sequences of studied genes and RNAs.
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PMC7812570
As shown above, we finely characterized the single-domain antibody m36.4 for its potential as a membrane-bound viral entry inhibitor when attached via a GPI anchor.
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PMC10605143
Moreover, HSF1 levels positively correlated with the invasive phenotype of triple-negative breast cancer cells, and their growth was inhibited by the HSF1 inhibitor DTHIB.The epithelium, one of the four main tissue types in the human body, is formed by cells, which are closely bound to each other to ensure the mechanis...
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PMC10547921
Chemical structures of auristatin analogs 7–10, 21–24; (B) Binding mode of compound 10 in complex with tubulin (PDB code 4X1I).
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PMC11638764
Cell Culture and anti-proliferative activity of CB-5083 The HL-60 (ATCC, cat# CCL 240) and HCT116 (Cat# CCL-247) cell lines were expanded in RPMI1640 (Sigma-Aldrich， cat#R8758) 10% FBS (Sigma, cat#F0926), 1% penicillin-streptomycin (Fisher, cat#15140122) medium, cultured at 37 C in 5% CO 2 incubator.
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PMC11381192
The nomogram demonstrated that CSI was the most significant predictor of OS compared with nearly all other factors.
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PMC10529414
The results revealed that RUNX2 was enriched at the promoter region of TALAM1 (Figure 3C).
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PMC9429973
4-week and 8-week mortality rates were 10% and 14%, respectively.
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PMC5363531
Preliminary cell culture tests have shown that DMSO (Volume 0.2% was the maximum amount used to deliver dasatinib) has no effect on cell viability, cell cycle, apoptosis, or signaling (data not shown).
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PMC11486946
Similar to the effects of most EGFR-TKIs, the five non-EGFR-TKI compounds (broxyquinoline, daunorubicin, eltrombopag, sorafenib, and verteporfin) suppressed the viability of the three EGFR-expressing cell types, while the other two non-EGFR-TKIs (glafenine and nilotinib) caused higher viability.
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PMC11805741
The UV/Vis scanning demonstrated its maximum absorption point at 470 nm (Fig. 2B).
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PMC11538390
Manhattan plots were generated using the ggplot2 R package.
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PMC7294030
p < 0.05, **p < 0.01, ***p < 0.001 This present study shows that aurisin A has promise as an anti-cancer agent, as evidenced by; i) inhibited cell proliferation and cancer cell migration (decreased EGFR and pp38 expression), ii) induced apoptosis (up-regulated caspase-3) and iii) cell cycle arrest at the G0/G1 phase wi...
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PMC11549062
Stable endocytic motility regulates compartmentalization and protein abundance within cells and is involved in many signaling pathways .
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PMC11525028
All calculations for protein-fixed ligand-flexible docking were done using the Lamarckian Genetic algorithm (LGA) method.
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PMC9429973
The frequency of post-transfusion reactions of transfused blood components was respectively: chill-rigor reactions in RCCs–9(0.09%), in FFP–3(0.14%), in PC–7(0.09%); FNHR in RCCs–10(0.1%), in PC–2(0.02%); ATRs in PC–19(0.23%), in FFP–1(0.05%); anaphylactic reactions in PCAP–2(0.06%).
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PMC11705484
L‐M) RNA‐binding protein pull‐down assays were performed using in vitro biotinylated anti‐sense (control) and sense (test) HMOX2 mRNAs, followed by RT‐qPCR analysis of HMOX2 mRNA and immunoblot analysis with TRMT61A and YTHDF1 antibodies in 5637 (L) and T24 (M) cells. (
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PMC11802929
i Construction of the large SCT-pMHC library representing HLA-A*02:01 peptide-MHC complexes covering antigens from across the full SARS-CoV-2 proteome.
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PMC11437637
Patients with obesity have high levels of inflammatory factors, such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α(TNF-α), and the endometrium lacks protective immune cells .
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PMC7802142
To detect miRNAs, miRcute Plus miRNA First-Strand cDNA Kit, qPCR Kit and primers (TIANGEN, China) were used following the manufacturer’s instructions.
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PMC11087055
Our data demonstrates that suppression of the Wnt/PCP pathway preserves the initiation and maintenance of the polonaise movements, but the lateral positioning of the rotations is enlarged when the PS is deformed (Figure 1 and Figure 1—figure supplement 1).
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PMC6617630
Break-apart probes target two areas of a MYC, BCL2, and BCL6 gene sequence.
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PMC9429973
Summary/Conclusion: No correlations between recurrent lesions within the JAK/STAT axis and clinical outcome were found.
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PMC9646302
Molecular markers of proliferation, migration, and invasion were detected in ccRCC mice using Western blotting.
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PMC11082662
Ovarian cancer is the third most common malignant cancer affecting the female reproductive system, following cervical and uterine cancers.
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PMC9516401
Among these analogues, two analogues showed hypoglycemic activity against this enzyme which, of course, had short-term effects (Mwenga, 2018 ▶).
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PMC11335267
Also, the absence of differences in the measurements of the tibia indicates that body length is unlikely to account for differences in body weight either.
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PMC6889484
Severely delayed kinetics were observed in the 20% CEMSS:80% CEMSS/D128K clone mix 28 days post-infection (bottom). (
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PMC11489351
EIPA, 5-(N-ethyl-N-isopropyl) amiloride; NH4Cl, ammonium chloride; pHi, intracellular pH. Work identifying pH sensors and pH-sensitive pathways has generally started from the pH-dependent biological outcome, identified essential pathways in that process, and then tested the pH sensitivity of critical pathway proteins o...
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PMC9429973
Analysis of the intermediate cytogenetic risk group showed patients with a low CHD4 expression had a worse outcome; which was comparable to the adverse risk group patients (P=0.032), indicating that loss of CHD4 may contribute to a more aggressive phenotype AML in this group.
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PMC11768927
Strategies to overcome resistance include enhancing viral oncoselectivity, inhibiting IFN responses, modulating the TME, and combining VSV with chemotherapies, radiation, and immune checkpoint inhibitors.
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PMC11629143
This suggests that the silencing of at least some promoter copies is reversible, a valuable discovery.
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PMC4270159
1 µM erlotinib + 50 ng/ml HGF.
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PMC11638288
The structure of NKp46 contains two extracellular immunoglobulin-like domain, a transmembrane domain with positively charged amino acid and a cytoplasmic domain does not possess any signaling motifs Molecular structures of NKp46.
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PMC9429973
In patients with vs without prior alloSCT, the medians (95% CI) for DOR were 14.6 months (8.7-23.6) vs NR (4.7-NE), and the medians (95% CI) for OS were 25.4 months (14.2-NE) vs NR (9.0-NE), respectively.
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PMC11532793
The divided-count approach models the precision of transcript quantifications from the kallisto and Salmon software tools and divides the estimated overdispersions out of the transcript read counts, after which the divided-counts can be analysed by statistical tools developed for gene-level counts.
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PMC11596967
In addition to GSH, bacteria generate other peptides with antioxidant properties.
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PMC11564322
Interestingly, the cell co-treatment with the c-SRC inhibitor I and VGVAPG or VVGPGA peptides increased the ELANE mRNA expression by 41.37 and 250.94%, respectively, compared to the control (Fig. 2E).
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PMC10958426
We further identified the tumor subclones and inferred the lineage relationship of these tumor subclones in CRC#1, which support the accumulation of mutations in each tumor subclone.
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PMC11087766
Number of infected cells coexpressing both sfGFP-tagged chimera and PicA-mCherry that have fluorescence in at least one channel above threshold displaying the indicated phenotype.
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PMC11687167
In addition, PCSK9 was found to upregulate the number of Th1 and Th17 cells and promote differentiation in patients with autoimmune diseases.
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PMC10728535
Since ionic channels in theory can be easily modulated, they serve as attractive therapeutic targets and pave the way for the development of personalized therapies aimed at stopping or slowing drug resistance process through ionic channel modifications.
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PMC11761919
The microcapsules were stored at 4°C.
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PMC11085211
These findings suggest a non-targeted but chemotherapy-like mechanism of action, which should not be underestimated considering the lack of effective chemotherapeutic agents for GIST patients.
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PMC8864075
p < 0.001; **p < 0.01; *p < 0.05.
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PMC11281366
A CEM-CD59_control cell line in which the CRISPR/Cas9 guide sequence was absent was also generated.
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PMC11786600
Demonstration of nanofibers during electrospinning.
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PMC11738017
Overall, 10 patients had WGS from serial samples (n = 22).
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PMC11740207
The existence of CSCs from transformed VSELSCs in vivo has been exemplified by very small CSLCs (VSCSLCs) and LSLCs (VSLSLCs) observed in vitro (Lica and Pradhan, 2023).
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PMC7602170
The standard first-line molecular-targeted therapy in GISTs is focused on imatinib for GISTs; but primary or secondary resistance is becoming increasingly prominent.
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PMC6742971
The overall T cell response is composed of multiple T cell clonotypes, involving different T cell receptors and variable levels of functional avidity.
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