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BioData-CellLine_annotated

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PMC10565698
6TCF12 is a target molecule acting downstream of miR-211-5p.
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PMC9024365
Specifically, SD4 slows the deactivation of GluA1 homomers, as well as GluA1/A2 heteromeric AMPARs.
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PMC11451940
The A2780 cells (Sigma, 93 112 519-1VL) were grown according to the manufacturer's instructions and seeded at 10 cells per well in 96-well plates.
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PMC10565698
7CircUSP10 promotes liver cancer growth and metastasis through miR-211-5p/TCF12/EMT.
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PMC11139449
Targeting apoptosis-related genes, such as Caspases 8-Associated Protein 2 (CASP8AP2), improves CHO cell viability and productivity.
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PMC9429973
Patients were eligible as per the EMA-approved decitabine label (newly diagnosed AML who are not candidates for standard induction chemotherapy).
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PMC11412721
Gene set enrichment analysis was performed using the GSEA software with canonical pathway gene sets from the Mouse Molecular Signature Database (Subramanian et al., 2005).
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PMC11547917
Caco-2 cells were used as an absolute control, and ethanol as a negative control.
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PMC9927933
H&E staining analysis revealed that while mice with Ube2c deletion alone [Kras(–)Ube2c] had normal lung development without any tumor formation (Figure 2B and Supplemental Figure 2C), the WT mice [Kras(+)Ube2c or Kras(+)Ube2c] developed, as expected, multiple lung adenomas with few adenocarcinomas (Figure 2B and Supple...
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PMC7090062
P < 0.05, **P < 0.01, ***P < 0.001 vs. IM.
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PMC11769516
It should be noted that the study indicates that MON and 3-AcDON have weak or almost no adverse effects on the BBB in vitro .
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PMC9429973
It can present either with asymptomatic monoclonal lymphocytosis or non-bulky nodal/extra nodal disease with minimal symptoms or with a progressive generalized lymphadenopathy, cytopenia, splenomegaly and extra-nodal disease.
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PMC9429973
In THRIVE-133 OLE, participants will receive IV inclacumab every 12 weeks as long as the clinical benefit of treatment outweighs the risk and until access to inclacumab from an alternative source (eg, through commercialization or a managed-access program) becomes available.
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PMC11679326
In addition, it was noted that decreased B4GalT-5 expression in glioma cells caused a decrease in polylactosamine synthesis and selectively depleted CD133 cells in the xenograft, thereby suppressing the ability of glioma cells to engage in self-renewal, which suggests an interesting role for B4GalT-5 in the formation o...
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PMC11476666
SOX2 levels, which were highest in SP cells, appeared to be the most affected by treatment with stilbenes.
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PMC11525028
Decay graphs were generated by applying the one-phase decay model.
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PMC6364197
The shortcoming of 2D culture is getting increasingly obvious by studies showing that cell behavior and gene expression are significantly influenced by the physical and mechanical properties of their microenvironment (7).
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PMC9429973
Flow cytometry analysis showed that EMCN HSCs were more quiescent as compared to EMCN HSCs (G0: p = 0.001; G1: p < 0.0001; S-G2M: p = 0.014; n = 10), and single cell cultures demonstrated that EMCN HSCs initiate their first division in vitro later than EMCN HSCs (undivided cells after 2 days- EMCN HSCs: 18.6% vs EMCN H...
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PMC10578720
once a day), while the other received a saline (vehicle) injection (0.9% NaCl, i.p.,
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PMC8041314
Reports that did not include biological investigations on all three transporters were not considered, as a subsequent classification of the compounds would fail due to missing activity value(s).
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PMC11721277
Its Tc-radiolabeling and primary preclinical studies were conducted to evaluate the potential for use in nuclear medicine imaging.
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PMC10798140
All selected compounds at high concentration (20 μM, higher than IC50) were cytotoxic against HepG2cells, as the percentage of healthy cells decreased significantly compared to the control, untreated group (p < 0.05).
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PMC11723947
Whereas HP1α coordinates the effect of immunosuppressive signals at the chromatin level, HP1γ negatively regulates the expression of immune checkpoints and thus limits T-cell suppression.
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PMC11705067
The structures of FDX1 (PDB: 3P1M) and DLAT (PDB: 1Y8N) were obtained from the Research Collaboratory for Structural Bioinformatics (RCSB) Protein Databank (https://www.rcsb.org/).
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PMC11599565
It appears however, that those cell types are extremely amplified in tumoral ovarian tissues, as revealed by IHC (E–H).
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PMC11787651
A and B, the ZenoTOF method recapitulates both the significant difference in expression and the peptide ratio of relatively abundant marks H3K27me3 and H3K14ac.
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PMC11742047
Data in the graphs represent the mean ± SD (n = 5 per group) of two different experiments.
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PMC11371747
L-LV (Fusilev) and pralatrexate (Folotyn) were gifts from Spectrum Pharmaceuticals (currently licensed to Acrotech, East Windsor, NJ, United States).
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PMC11525293
Recent reviews on the COVID-19 treatment endorse the possibility of usage of Thal and its analogues for treating COVID-19 patients.
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PMC11637284
A kDNA area value of zero means the complete loss of the kDNA. (
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PMC10890055
However, the sensitivity of the hFOB 1.19 cell line to Zn has not yet been studied.
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PMC11087766
Infected cells were then binned into two categories, those containing a DAPI stained focus greater or less than 0.5 µm.
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PMC11745600
An additional advantage of using NOG mice is the existence of an efficient production system facilitated by optimized reproductive techniques.
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PMC11711935
The authors have nothing to report.
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PMC8750422
The accession numbers of collected data were GSE19188 and GSE10072.
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PMC10882807
Knockdown of EIF4A3 could reverse hsa_circ_0005397 function in HCC progression.
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PMC11089031
C WB tested the effects of KD and OE of ZNF692 in 786–0 and Caki-1 cell lines.
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PMC7685376
All animal experiments were conducted in the Experimental Center of Shanghai Municipal Hospital of Traditional Chinese Medicine and approved by the Ethics Committee of Shanghai Municipal Hospital of Traditional Chinese Medicine and performed according to the NIH Guide for the Care and Use of Laboratory Animals.
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PMC9429973
Notably, it is important to determine that whether the variable ability of T cell to repair DNA damage also translates into the corresponding molecular profiles of T-ALL.
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PMC11576293
The ORTEP plot shows that the pyrimidine ring, its 2 aryl substituents (rings A and B), and the S-benzyl group were found on pyrimidine C-2.
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PMC9878562
Weights are reported as means ± SD from three independent xenograft experiments with 4-5 animals per group.
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PMC11462673
The two groups were compared by double-tailed unpaired Student's t test for data analysis.
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PMC9429973
Early results demonstrated consistent safety and efficacy profile of brexu-cel as observed in ZUMA-2 in a population with broader demographics, disease and treatment profile.
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PMC11106977
The above studies hint that regulation of O-GlcNAcylation metabolism in these cells may have clinical applications.
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PMC11657695
After this, cells were incubated with a secondary antibody (Goat anti-rabbit Alexa-Fluor 488, Thermofischer) for one hour at room temperature.
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PMC9429973
M. Tobiasson, T. Pandzic, J. Illman, L. Nilsson, S. Weström, K. Sollander, E. Ejerblad, A. Olsnes Kittang, G. Olesen, O. Werlenius, A. Björklund, J. Wiggh, C. lindholm, F. Lorentz, B. Rasmussen, J. Cammenga, D. Weber, D. Grönnås, M. Dimitriou, S. Kytölä, G. Walldin, P. Ljungman, K. Groenbeck, S. Mielke, S. E. Jacobsen,...
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PMC11496728
In addition, the SEAP concentrations in pCMV-SEAP, pCMV-SEAP-1, and pCMV-SEAP-2 transfected into CHO-KO cells were increased by 1.74-, 1.75-, and 1.71-fold, respectively.
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PMC11332076
Similar effects were observed in Cos-7 cells transfected with F-iIGF1R and iIGF1R (lower panel in Fig. 2A).
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PMC4485648
Transfected cells were allowed to attach overnight, and then transferred to hypoxia for additional 24 h. SFN was added 4 h before the transfer to hypoxia.
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PMC11506827
Then, the wound size was quantified again after treatment for 24 h to indicate how much wound closure (%) was achieved through comparison of the two-wound size.
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PMC11704834
Third, the development of acquired gefitinib resistance in A549 cells resulted in upregulation of TLE1 expression which functions to safeguard cells from EGFR-mediated apoptosis.
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PMC11286266
However, this feature complicated interpretation of experiments designed to establishing the role of ATF6α_LD glycans on CRT-mediated repression of ATF6α: failure of CRT deletion to derepress the BiP::sfGFP signal in ATF6α_LD knock-in cells (Figure 5—figure supplement 1) could be interpreted as either an obligatory rol...
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PMC7762347
DSBs are an extremely damaging form of DNA damage as they can cause mutations and chromosomal rearrangements .
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PMC11604015
Naturally selected autologous CAR-T cells can resist fratricide without additional genetic editing.
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PMC9000591
The cytotoxic activities against the selected cells were analyzed in this study by MTT assay.
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PMC9429973
Considering the time at relapse, 53 patients (50%) were registered as relapsed (median time at relapse 10.8 months, IQR: 6.9;20.9) and 54 (50%) as refractory (0.9 months, IQR 0.52;1.3).
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PMC11747467
Notably, luminal and basal cells exhibited different growth morphologies: cohesive clusters of epithelial cells in luminal cells, and mesenchymal and squamous differentiated morphology in basal cells ( Supplementary Figure S5B ).
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PMC10938336
Using current treatment strategies, roughly 33% of patients can be treated with localized treatment methods such as radiation or surgery.
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PMC11792888
Western blot of apoptosis-related protein caspase 3. (
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PMC11489351
Figures 2, A and B, S1, A–C, and S2 were created using R/RStudio or PCAExplorer package for R and modified in Adobe Illustrator.
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PMC11574271
In other words, MMP12 is a downstream effector molecule that plays a key role in driving bladder cell cancerous migration and invasion.
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PMC9429973
D. Kim, E. Atenafu, D. Forrest, I. Bence-Bruckler, L. Savoie, M.-M. Keating, L. Busque, R. Delage, A. Xenocostas, E. Liew, P. Laneuville, K. Paulson, T. Stockley, J. Lipton, B. Leber Princess Margaret Cancer Centre, Toronto, Canada; Statistics, Princess Margaret Cancer Centre, Toronto; Vancouver General Hospital, Vanco...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Aims: To examine the immune microenvironment of the BM in archival AA and PGF BM trephines and identify common immunopathologies.
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PMC11544122
SNX9/18 is not required for short-term desensitization (Supplementary Fig. S2) nor ERK1/2 phosphorylation (Supplementary Fig. S3), suggesting the main function is to mediate CXCR4 endocytosis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4839679
Cells were harvested in the logarithmic growth phase and counted by MOXI Z Mini Automated Cell Counter (ORFLO Technologies, Ketchum, ID).
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PMC11387401
The observed binding of Tat with the mRNAs of protein subunits of the SEC, indicates that their nascent transcription might be regulated, similar to Tat transcription, in a feed-forward loop, increasing the levels of the subunits of the SEC, to meet the increasing demand during HIV-1 infection (Skalska et al, 2017).
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PMC11574271
C The invasive potential was evaluated using a trans-well assay.
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PMC9681981
The sequences and characteristics of primers used for cpa, etx, and 16S rRNA genes are presented in Table 2.
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PMC11704135
4Mass fragmentations of compound 9.
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PMC11423992
However, several reported modalities that employ T-cell recruitment via TDBs encounter limitations due to unfavorable pharmacokinetics (PK), potential concerns about immunogenicity, and manufacturing challenges .
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PMC11190062
Thus, TLR signaling in MM cells can theoretically both enhance and reduce the efficacy of BCMA-targeting drugs.
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PMC9509578
Polymers such as poly (aspartic acid) (PAA), poly (caprolactone) (PCL), poly (lactic-co-glycolide) (PLG) and polyethylene glycol (PEG) are used for micelle formation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
This power of stratification was maintained after applying the revised ELN proposed by Herold et al., 2020.
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PMC9429973
Our results help the clinician to identify this group of patients to avoid diagnostic dilemmas and allow them to modify their therapeutic decisions.
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PMC11803149
Thus, Epas1 may be a biomarker to predict the age-related decline in anti-tumor efficacy of ACT using tumor-specific CD8 T cells.
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PMC11721587
SUMOylation sites have consensus motifs: ψKxE/D and E/DxKψ (inverted site), where ψ is a large hydrophobic amino acid and x is any amino acid (53).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11380454
Moreover, the overexpression of Akt in B16/F10 cells (Table 1) or NFκB in Wehi-3B cells (Table 1 and Fig. S5) abrogated the ability of SAS to induce CTL-mediated cytotoxicity in these cells.
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PMC11592837
In addition to active cell division, Jurkat cells were reported to harbor a tetraploidic genome , which, after its degradation, may have also facilitated a higher n-cfDNA formation.
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PMC7823217
Nevertheless, this is not always feasible, hence the most suitable biobanked stromal cells should be selected for the tumor type.
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PMC10808409
The expression levels of TP53INP1, Bax and CASP-3 were significantly increased in treated groups with TPGS as compared to the untreated cells at P < 0.0001, with a prominent effect for O2 as compared to FA (Table 6, Figs. 7, 8).Table 6Effect of O2 and FA on miR-221, Bax, CASP-3 expression in Caco-2 cell line.miR-221Bax...
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11321678
Within these chromatin accessibility profiles, specific regulatory elements tied to individual subgroups are uncovered, shedding light on the distinct activities of transcription factors (TFs) that likely orchestrate the tumorigenesis process.
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PMC11757131
Therefore, fatty acid transport plays a decisive role in milk fat synthesis.
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PMC11621493
These data indicate that PLA2G4D interacts with membranes from multiple organelles in a Ca-dependent manner.
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PMC10705095
In addition, our xenograft results also showed that HBQ1 knockdown inhibited tumor growth in vivo.
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PMC11394227
In the process of stable overexpression of Ero1 and PDI, it was found that antibody expression did not achieve the expected increase effect, which suggested that the productivity may depend on the expression level of PDI and the ratio of Ero1 to PDI.
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PMC11321678
For a given TF, the correlation of motif deviation scores and gene activity scores between each TF to all of the genes were first calculated and a correlation score >0.5 was set as a cut‐off.
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PMC11291490
Within the spectrum of zoonotic pathogens, avian species often serve as either intermediate or natural hosts.
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PMC11552389
P < 0.05 was the significance threshold.
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PMC10870498
After the immunoprecipitation reaction, the complex was centrifuged at 4 °C, 3,000 rpm for 3 min.
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PMC9429973
We identified WHO-defined PMF patients and collected their demographic data, bone marrow findings, driver mutations, clinical and hematologic characteristics.
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PMC7887261
Gene constraint LoF o/e values developed with gnomAD: observed counts are based on sequencing data from gnomAD, expected counts are based on a mutational model that takes sequence context and coverage into account.
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PMC9429973
2016; Allen UD, Am J Transplant, 2019; Nijand M, Transplant Direct, 2016).
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PMC8708099
Negative control samples without cDNA and an inter-run calibrator were included in each assay.
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PMC10747139
The antiviral activity of 60 was evaluated by measuring the virulence of the progeny viruses of the H1N1 group and the H1N1+60 group (TCID50, a median-tissue-culture infective dose).
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PMC9318744
Thus, the internalized viral RNA utilizes the host’s cellular protein machinery to counter antiviral responses in the host cell .
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PMC11394227
A comparison of the tGSH concentration of CHO-PAb and CHO-PAb-QS cells with that of wild-type CHO-K1 cells revealed an increase of 13.6% and 18.6%, respectively.
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PMC11743414
D The mRNA expression level of FHL1 was detected by qRT-PCRFig.
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PMC11742864
Notably, although the current preclinical evidence basically supports the tumor inhibitory effect of LCPUFAs, especially ω-3 LCPUFAs, the controversy regarding the relation between LCPUFAs and lung cancer risk still remains, and the discrepancy between the results could be the source of ω-3 LCPUFAs, the type of ω-3 LCP...
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PMC11413393
Data are presented as mean foci counts ± SEM.
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PMC11726848
Human epidermoid carcinoma A431 cells were irradiated under the LDR (0.5–3 Gy/h) regime and HDR (600 Gy/h) regime in the same dose range (2–64 Gy).
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