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OTAR3088
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BioData-CellLine_annotated

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PMC10745221
Future studies could use proteomics and RNAseq analyses in parent and revertant cells to elucidate the pathways important for methionine dependency.
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PMC7570809
Cellular network structures were already developed by 6 h. In Figure 6A the formation of new capillary tubes is evident and, interestingly, in the sample treated with RGDechi15D results to be significantly reduced.
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PMC11545737
YopE activates Pyrin by triggering its dephosphorylation at Ser205 , which appears to be a conserved mechanism since the Clostridium difficile RhoA-inactivating enzyme TcdB acts in the same way on Pyrin .
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PMC6450504
The lack of effect may be attributed to the low-dose regimen used in this study.
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PMC10387886
Western blot was used to analyze phospho- and total MAPK protein levels.
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PMC10938336
In this network, nodes represent compounds and their associated proteins, while solid black lines represent interactions between target proteins and compounds.
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PMC10933092
Bladder cancer (BLCA) is the most common malignant tumor of the urinary system and ranks sixth among malignancies in men (Siegel et al., 2022).
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PMC11144200
n = 3, *** P < 0.001, ****P < 0.0001.
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PMC10547921
Payloads containing amines and anilines can be conjugated to the antibody via carbamate bonds, which are more stable than carbonate or phosphate bonds provided by hydroxyl groups.
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PMC7351993
For detecting nuclei, the spot detection algorithm provided by NIS Elements was used.
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PMC11547917
The total phenolic content has a low value, showing a low content in polyphenols, but the total flavonoid content has a high activity suggesting a high content in flavonoids.
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PMC11568601
Previous studies have suggested that ATF6 fine-tunes the UPR, which is modulated mainly by the predominant IRE1α- and PERK-dependent responses .
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PMC7582629
Besides this, a small increase can be seen in the intensity of band at 1350 cm in the red spectrum, once more suggesting a structural DNA modification.
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PMC6450504
Cells were seeded into 6-well plates at 100,000 cells/well.
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PMC10006224
Additional proteins interact with cohesin and regulate its behavior, most prominently NIPBL, PDS5A/B, WAPL, SORORIN, ESCO1/2, HDAC8 and CTCF.
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PMC9966931
Control and treatment samples were prepared in triplicate.
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PMC5916734
The varying activity levels of the VKOR complex are the reason why different cells have different abilities to ensure the γ-carboxylation reaction.
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PMC11621493
Genes with average expression across all samples >10, more than 1.5-fold change and FDR <0.1 were considered significantly differentially expressed.
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PMC4360730
Correcting these errors involves gathering the relevant citations to resolve the discrepancy.
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PMC9841531
The ability of the most potent MCT1 inhibitors 24 and 30 to enhance the susceptibility of the MCT1-expressing cell lines A-549 toward antineoplastic agent 33 was investigated.
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PMC9985266
The secondary antibodies were added, and TBST buffer was used to wash the PVDF membranes.
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PMC11786704
The schematic diagram shows the establishment of skin wounds and treatment protocols (Fig. 4A).
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PMC9250505
However, synergistic interactions between inhibition of BADS99 phosphorylation and PARPis in EOC including either BRCA-deficient or proficient and/or platinum-resistant models were demonstrated.
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PMC11599565
Interestingly, TH was found enhanced in cisplatin sublines.
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PMC11787381
In addition to their theoretical potential as disease-modifying agents in AD, epidemiological data suggests that long-term use of β2-AR agonists may reduce the risk of developing Multiple Sclerosis (MS), Parkinson Disease (PD), and AD among asthmatic patients.
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PMC11707577
Interestingly, the genes involved in the programmed cell death, like Bcl2 and Casp‐3, were found not significantly modulated, indicating the induction of a fast necrosis process rather than a slower apoptotic pathway by the M13EGFR(TNP) photostimulation.
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PMC11472639
NK-cell populations were immunophenotyped via direct immunofluorescent antibody staining procedure of thawed PBMCs using the following antibodies: anti-CD3-PE-Cy7 (UCHT1), anti-CD56-PECF594 (NCAM16.2), anti-CD14-BV605 (M5E2), anti-CD38-BV421 (HIT2), anti-CD57-FITC (NK-1) (BD Biosciences, Wokingham, UK), and anti-CD16-A...
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PMC9429973
Despite great advance in the standard of care in the last decades, there are still unmet medical needs (long-life treatment, resistance…).
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PMC11635087
The isolated chloroplasts were spherical structures with a diameter of approximately 2 μm (Fig. 1B).
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PMC5963610
Tumor cells recovered from 3LL-metastases post-treatments were obtained to determine the expression/activation of Src (A), p-Src (B), FAK (C) and p-FAK (fosfo-FAK, D) by flow cytometry.
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PMC9429973
At median follow-up of 46.5 mo (acala) and 45.3 mo (IdR/BR), acala significantly prolonged INV-assessed PFS vs IdR/BR (median not reached [NR] vs 16.8 mo; P<0.0001); 42-mo PFS rates were 62% for acala vs 19% for IdR/BR.
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PMC11802929
Charge values represent the average of positive and negative charges rather than the absolute value.
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PMC11388384
However, when we disrupted cytonemes on both sender and receiver cells with Latrunculin A, which limits actin polymerization by tracking actin in its monomeric state, SHH signaling gradients were not affected, despite a ~50% reduction in the number of cytonemes (19) (Fig. 1 F and G).
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PMC11720808
However, the anti-cancer effect and mechanism of SCU on OS are still unknown.
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PMC11087301
By evaluating clinical samples from glioblastoma patients, Jia et al. revealed that expression level of oncogene Golgi phosphoprotein 3 (GOLPH3) was positively correlated to VM and a higher pathological grade.
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PMC11144200
n = 3, **P < 0.01, ***P < 0.001, ****P < 0.0001.
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PMC11321678
And the specific TFs in Group 3 and Group 4 were ranked by enrichment score (Figure 3C).
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PMC10170482
Green, red, and merged channels are assembled as multistack montage images with maximum intensity projection.
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PMC11676674
The IC50 of the C. monspeliensis extract was determined to be 228 µg/mL. The CBMN assay is widely utilized for assessing DNA damage, evaluating the genotoxicity of chemicals, and potentially preventing genotoxicity and cytotoxicity .
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PMC9429973
All patients detected the WT1 mRNA expression of bone marrow and peripheral blood at diagnosis.
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PMC8041314
The data provided in Supplementary Table 2 was translated into a script (ABCB1, ABCC1, and ABCG2), and the compounds classified as follows: (i) class 0: 0, 0, 0; (ii) class 1: 1, 0, 0; (iii) class 2: 0, 1, 0; (iv) class 3: 0, 0, 1; (v) class 4: 1, 1, 0; (vi) class 5: 1, 0, 1; (vii) class 6: 0, 1, 1; (viii) class 7: 1, ...
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PMC6650823
Moreover, the efficacy of these drugs is unsatisfactory, so novel leads are urgently required.
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PMC9429973
O. Yin, K. Baron, J. Mondick, M. Little, P. D. Tyler, V. Beynon Agios Pharmaceuticals, Inc., Cambridge, MA; Metrum Research Group, Tariffville, CT; Metrum Research Group, Tariffville, United States of America Background: Mitapivat (AG-348) is a first-in-class, oral, small molecule, allosteric activator of the red blood...
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PMC8992508
Continuing their previous researches on derivatives of the natural alkaloid Pervilleine A, and based on the polyvalency approach, Teodori et al. synthesized a set of basic molecules carrying aryl moieties connected to the N-containing linker through ester functions.
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PMC11763533
COS-1 cells were acquired by Rio de Janeiro Cell Bank (BCRJ, cell type code 070 batch number 000114).
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PMC11742670
A 100 µL suspension containing 5 × 10 cells was seeded into 96-well plates and incubated in a complete medium for 24 h. The cells were then treated with 100 µL of medium containing the test samples at varying concentrations (0.01, 0.1, 1, 10, and 100 µg/mL).
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PMC7351993
Our evaluation of the sorted and unsorted cells under a fluorescence microscope (Supplementary Fig. 9c) indicates that the RIACS with SIP can be used to monitor and sort out metabolically active cells (capable of catabolizing or anabolizing molecules) from a population to study their genes and metabolic pathways.
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PMC11755624
Table 1 summarizes the expression of selected lncRNAs in patients with psoriasis.
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PMC11594588
Etheno bases were first described by Kochetkov , who identified them as fluorescent analogs for biochemical studies and probes for nucleic acid structures , although among different exocyclic adducts, only 1,N-ethenoadenine possesses fluorescent properties.
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PMC11754432
Cell pellets were resuspended in methanol/H2O (50/50 v/v), antioxidant and inhibitor solution was added and suspension was sonicated for 8 s using an ultrasonic tip as described .
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PMC11720107
Interestingly, the Violeta cultivar did not significantly affect PPARγ or LC3A mRNA expression but strongly decreased PPARγ and LC3A protein expression.
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PMC9429973
Furthermore, blockade of γc cytokine signaling led to reduction in activated and proliferating T cells in CM and demonstrated potent inhibition of allogeneic responses in mixed human lymphocyte reaction assays, by preventing T-cell activation and proliferation.
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PMC9429973
Safety analyses were based on all treated patients; efficacy analyses were based on the intention-to-treat population randomized at least 22 weeks prior to study end.
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PMC10999934
Recent studies have shown a connection between endoplasmic reticulum stress and resistance to chemotherapy, with the suppression of this stress improving the efficacy of chemotherapeutics in various cancer types [, , ].
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PMC11707832
Mannosidase alpha class 2B member 1 (MAN2B1) is a lysosomal hydrolase from the α-mannosidase family.
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PMC11767582
C NMR (75 MHz, CDCl3) δ 153.6, 138.8, 136.3, 133.6, 131.75, 131.6, 131.3, 130.9, 130.4 (q, J = 1.2 Hz), 128.9, 125.8 (q, J = 12.3 Hz), 123.6 (q, J = 272.2 Hz), 102.8, 60.9, 56.2.
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PMC11730305
XRD analysis shows the peaks at 2θ between 30–40° are related to Co3O4.
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PMC9429973
All DNA samples were tested using a real-time AS-PCR with the following primers and probes: c.1441T (5’-CTGAGTACATGGCCAATGGCT-3’); c.1441T>A (5’-CTGAGTACATGGCCAATGGCA-3’); c.1442G (5’-CTGAGTACATGGCCAATGGCTG-3’); c.1442G>C (5’-CTGAGTACATGGCCAATGGCTC-3’); c.1442G>A (5’-TGAGTACATGGCCAATGGCAA-3’); c.1442G>T (5’-TGAGTACATGG...
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PMC10454535
This combination’s effects on normal PBMC cells were also examined using the same cell viability assay.
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PMC11367146
The treatment of cells with VTE up to 100 μg/ml did not result in cell spreading and pseudopodia development, indicating that the majority of the cells were alive (Fig. 10A and B).
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PMC10996034
The results indicated that MMP1 and ZYX may be specific in Taxol resistance in EOC, while the common resistance occurrence and mechanisms of UNC5C in EOC and HNSC remain to be explored.
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PMC7185206
P < .001, ** P < .01, * P < .05.
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PMC9429973
Furthermore, groups of patients with c-MYC/BCL2 HGBL DH and HGBL TH were predominantly presented by GCB-subtype (93%) while c-MYC/BCL6 HGBL DH – by non-GCB (44%), (p=0,03).
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PMC10723784
All compounds were dissolved in ethanol or filtered sterile water, and the final concentration of ethanol did not exceed 1%.
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PMC11502443
The reasons for this difference are unclear.
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PMC11271278
A Schematic models illustrating the identification of HAPI genes based on enhancer interactions.
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PMC10587429
No significant difference in tumor growth between humanized and non-humanized mice was noted at time points of week 1-4 post tumor cell implantation ( Figure 3C ).
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PMC11676670
Therefore, the origin of a cancer cell line should be carefully taken into account.
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PMC9684669
Lower panel: Western blot analysis of CREB1 and p-CREB1 (s133) in the nucleus of MDR ovarian cancer cells treated with terfenadine (Ter) for 6 h. Histone H3 (H3C1) was used as the loading control. (
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PMC11564322
The VGVAPG and VVGPGA peptides were synthesized by LipoPharm.pl (Gdańsk, Poland).
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PMC8623816
For ribavirin treatment, mycelial plugs of strain D122 were inoculated on water agar (WA) medium containing ribavirin (100 µM) and cultured at 28–30 °C.
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PMC9429973
Results: We report a set of peripheral blood EV-proteins (PDIA3, C4BPA, BTN1A1, APRIL, PSMB8 and PDE8B) that have the potential to be used as new diagnosis biomarker for myeloma patients.
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PMC11697065
Carbamidomethylation of cysteines was specified as fixed modification, with methionine oxidation and N-terminal acetylation (protein) set as variable modifications.
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PMC10243817
Cells were then either harvested (as time 0) without any additional treatment or further cultured in the presence of the transcriptional inhibitor actinomycin D (ActD) (5 μg/mL; AAT Bioquest) for 0.5, 1, 2, or 4 hours.
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PMC11707577
Photosensitizers can absorb light at a specific wavelength and be promoted from their ground state (S0) to the first singlet excited state (S1).
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PMC11194678
F–H) Representative confocal images of COS7 cells cotransfected with mCherry-Synphilin-1 and control PEGFP-C3, EGFP-STAU1 WT, 5KE mutant, or HKΔRBD4 mutant.
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PMC10874773
The structural feature of this type of compounds is mainly the formation of a δ-lactone ring after the ring opening at the C7-C11 position (Fig. 3).
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PMC11792888
The early increase of phosphatidylserine exposure on the outer plasma membrane in cells (Figure 3) and the absence of Bax/Bcl-2 ratio upregulation (Figure 5) suggest a mitochondria-dependent apoptosis [43-45].
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PMC6160470
As such, we supposed that they might sensitize MDR cancer cells to conventional chemotherapeutics.
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PMC9926039
In addition, in silico docking analysis revealed docking of methadone to MD-2 and TLR4.
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PMC11413393
P-values are calculated by two-tailed unpaired t-tests with Welch’s correction.
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PMC6889484
HIV-1 has evolved to combat A3G by expressing Vif, which targets A3G for polyubiquitination and proteasomal degradation, thereby preventing its virion incorporation.
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PMC11401350
Importantly, we detected a much higher level of expression (mean fluorescence intensity, MFI) for the PGK promoter than the EF1a promoter construct and no differences in the T cell subpopulations were detected as compared to untransduced T cells (Fig. 1B).Fig.
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PMC11583010
α-Amanitin is a potent RNA polymerase II inhibitor that kills both dividing and quiescent cells and was investigated as a payload as it has poor cell permeability, thereby avoiding bystander effects and allowing measurement of cytotoxicity solely mediated by ADC internalization.
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PMC11546117
Data were analyzed with the Student’s t test comparing the MFI of the negative control and the MFI of single stained cells (p < 0.05).
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PMC11747949
Lastly, we went on to explore the effects of CCR2 blockade on the same selected cellular markers in the in vivo model.
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PMC9429973
Methods: Forty eight pts with MM with median age 56 (range 21-76) were undergoing AHSCT in our center in years 2011-2013.
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PMC11698348
Our data suggest that in the epidermis, Elf5 may function, in part, by restricting the proliferative potential of stem/progenitors as they transitioned from basal to suprabasal layers.
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PMC11547917
This type of cell line was used because of its good reproducibility and predictability of antioxidant activities in vivo .
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PMC6182045
For comparison, CHO derived TZ97008-rgp120 was expressed via transient transfection using a method as previously described (24).
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PMC11622247
It is not possible to selectively excite and read the emission of the donor dye or the acceptor dye.
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PMC11694066
Mitomycin C, thymidine, iodo-deoxyuridine, and 5-chloro-2′-deoxyuridine were purchased from Sigma-Aldrich.
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PMC11564322
The c-SRC inhibitor I increased the cMYC mRNA expression by 49.45%, compared to the control.
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PMC3765139
CD133+ D10 cells formed tumors in NSG mice contrary to CD133- cells and CD133 expression was detected in xenografts and primary human melanoma sections using immunohistochemistry.
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PMC9429973
All patients gave written informed consent.
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PMC11659921
However, tumor blood vessels differ structurally and functionally from normal tissue blood vessels, exhibiting characteristics such as pericyte relaxation, distorted distribution, and excessive expansion.
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PMC2196094
A ∼12-kD band gave the NH2-terminal sequence Ile-Ile-Gly-Gly-Val-Glu, indicating that it is an RMCP-1 fragment containing the intact NH2-terminal.
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PMC9429973
According to the immunophenotypic variant of ALL, 27 (59%) were patients with B-ALL, of which Ph-positive ALL was diagnosed in 8 (30%), Ph-negative - in 19 (70%); T-ALL - 16 (35%), biphenotypic - 2 (4%).
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PMC11705862
The highest expression levels of IRIS-1 and 2 were found in the cell bodies of NeuN positive neurons localized within the CA1 region of the hippocampus (Fig. 1G, H).
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PMC11743316
As shown in Table 1, there are several inhibitors for various ETC complexes, such as tamoxifen for inhibition Complex I , malonate and nitropropionic acid for inhibition Complex II , antimycin A and resveratrol for inhibition Complex III , doxorubicin and porphyrin for inhibition Complex IV , and oligomycin for inhibit...
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