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OTAR3088
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BioData-CellLine_annotated

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PMC11407042
This study did not generate new unique reagents.
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PMC7185206
For immunohistochemistry (IHC), specimens were sectioned (5 µm) and stained with antibodies against ADAM10 (Abcam, clone 11G2), ADAM17 (Lifespan Biosciences, clone 1F6), or PD-L1 (Cell Signal, clone E1L3 N).
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PMC11206251
Hence, TCM and its bioactive compounds can be explored as safer alternatives in the form of combinational treatment strategies in addition to interventional therapy, targeted therapy, and immunotherapy.
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PMC11764090
ABA-dependent cold-resistance pathways have been identified in a variety of plants.
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PMC9096373
The combination of APA and RT might have a synergistic effect on anti-tumor angiogenesis.
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PMC11012313
BJAB or Ramos cell lines were plated at a concentration of 2 × 10 cells per well using 6 well plates in complete RPMI at 37 °C, 5% CO2.
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PMC7823217
with the permission of Springer Nature.
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PMC11794568
The light units of the ATP standard solution and the samples were obtained by Microplate Autoreader (Bio-Rad, Hercules, CA, USA) assay.
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PMC9583612
Several recent peer-reviewed studies describe the performance parameters of these technologies in detail.
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PMC10968586
In vitro, 20–80 μM OLE reduced hepatoma Huh7 and HepG2 cell line viability in a dose-dependent manner in 24 h .
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PMC10988555
P NMR [(CD3)2CO, 161.97 MHz] δ/ppm: 41.16 [s, PPh3].
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PMC9429973
A biopsy was performed and a promyelocytic infiltrate was found.
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PMC10988555
Besides the total cellular fraction, and to understand if complexes were able to accumulate in different cellular organelles, such as mitochondria and nuclei, we have also evaluated, by ICP-AES, the % of cobalt in those subcellular localizations for the three complexes.
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PMC2196094
These values may be slight underestimates, since these probes do not contain sequences from the 3′ non-coding regions of the mRNAs and clones shorter than 300–500 bp may thereby escape detection.
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PMC11757230
The OD450 values were calculated as follows: OD450 of LL cells with cADSCs minus OD450 of cADSCs alone.
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PMC7917457
The VALO-D102 virus was generated using a novel in vitro recombination method (submitted elsewhere).
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PMC11790971
Namely, for each passage, 857 cells were sampled from monoclonal wells, whereas 2058 cells were sampled from the artificial pools.
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PMC9429973
The probability of treatment discontinuation did not significantly differ for ponatinib in second, third or subsequent line of therapy (p=0.58).
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PMC11529598
Except wildtype TP53INP1, a mutant TP53INP1 was also constructed to disrupt the interaction between miR-3154 and TP53INP1 mRNA.
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PMC10604092
Subsequently, we stained 10 µm cryosections of the rat skeletal muscle tissues with hematoxylin and eosin.
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PMC9964635
Thin-layer chromatography was used for monitoring the reaction.
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PMC9429973
In titration studies, it was shown that the fusion panel can detect the template DNA fragments in trace amounts up to 1 pg.
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PMC7724160
0.25 mL of 0.2 M phosphate buffer (20% D2O, pH 7.0) was mixed with 0.5 mL of supernatant.
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PMC11139449
To alleviate this concern, careful design and validation of guide RNAs (gRNAs) is crucial to ensure specificity and minimize off-target effects.
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PMC10932641
Immune-related genes (IRGs) are not only associated with the response to immunotherapy, but also with the prognosis of RCC patients.
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PMC6450504
However, the signal from 0.5%PEIPOS was significantly higher in layers starting from 30 μm, with the difference of approximately 75% at 50 μm.
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PMC9792775
According to previous studies, ultrasound irradiation can enhance the antitumor effect of chemotherapeutic drugs in vitro (Panzone et al., 2022), and the mechanism of increased chemosensitivity of ultrasound-treated cells is not well understood, while cavitation and resealing of cell membranes by acoustic pressure are ...
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PMC11638255
GD2 is a tumor antigen ubiquitously expressed by the majority of neuroblastomas with anti-GD2 therapies known to promote antibody-dependent cell-mediated cytotoxicity (ADCC) by Fc-expressing immune effectors.
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PMC10047551
In line with these results, clinical trials are testing the anti-PD-1 antibody pembrolizumab combined with demethylation agents to further examine the potential of sensitizing NSCLC patients to PD-1/PD-L1 axis immunotherapy .
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PMC7305184
For easier presentation we separated permeabilization and survival curves.
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PMC11361748
Quantification of PKCα membrane localization was based on the intensity of the PKCα signal on a line profile (line width 20 μm) across adjacent cells.
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PMC11143482
Nowadays, xenograft models are extensively used, in which human cells are transplanted into immunocompromised mice and proliferate.
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PMC6450504
For the tumor inhibition assay, when tumors reached approximately 150 mm, animals were randomly separated into 5 groups (n = 4).
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PMC11055323
two-sided, unpaired t-test, ****p < 0.0001, n = 6, from 3 independent experiments.
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PMC11343332
Furthermore, the research elucidates the anti-migrative potential of pycnogenol, particularly its impact on VEGF/FGF signaling pathways.
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PMC9429973
The complications associated with bloodstream infection in the form of bacteremia or fungemia, which were observed by bacteriological culture, were detected in 74 (2.4%) patients.
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PMC10994876
Quantitative PCR (qPCR) was conducted using the SYBR Green qPCR master mix (Yekta Tajhiz Azma Co; Tehran, Iran).
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PMC11803918
Cells were incubated with anti-CRT or HMGB1 primary antibodies overnight at 4 °C.
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PMC11721064
Immunoreactive bands were visualized using chemiluminescence and quantified by densitometry using BandScan software.
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PMC11297139
Bars represents the mean ± SEM; **p < 0.01, ***p < 0.001, NS non-significant.
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PMC11737091
In brief, proteins were separated and transferred to PVDF membranes and then incubated with primary antibodies against DBF4 (abcam, ab124707, 1:10,000 dilution), CDC7 (Proteintech, 17980-1-AP, 1:3000 dilution), Cylclin D1 (Proteintech, 26939-1-AP, 1:4000 dilution), CDK4 (Proteintech, 11026-1-AP, 1:3000 dilution), phosp...
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PMC11547972
β-Actin (1:1000; clone AC-15; Sigma-Aldrich) served as the internal control (see also Supplement S1).
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PMC9429973
Results: In the intent-to-treat population (N=652; zanubrutinib, n=327; ibrutinib, n=325), adjusted completion rates were high (>85%) in both arms at Cycles 7 and 13.
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PMC9895440
i Heatmap of all differentially regulated genes between the four conditions showing row-scaled log-cpms and clustered using k-means (numbers indicated on the left).
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PMC11638255
e Split UMAP representation of immune cell compartment (12,127 cells) according to treatment arm and colored by annotated immune subsets.
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PMC10747160
Raji cell trans-infection assays were inspired by protocols described previously with some modifications .
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PMC11568601
Two concentrations of TGT (40 and 80 mg·mL) were set up to identify DEGs by pairwise comparisons with the untreated group.
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PMC10743717
PDB:1S08).
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PMC10969097
The study is ongoing and still in the recruitment phase; no results are available.
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PMC11634027
Scale bar: 100 µm. (
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PMC10158546
Synthetic mouse-adapted prion strains are needed because of transmission barriers that are mainly attributed to differences between the amino acid sequence of host-encoded PrP and PrP present in the inoculum .
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PMC11092382
These effects reverse the arrhythmias induced by isoproterenol.
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PMC9918897
The antioxidant capacity of the animals’ plasma was also analyzed.
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PMC9583612
The CEMS used in this study were used during the 6 months of the enhanced monitoring phase as event detection sensors since quantification was not available.
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PMC10900886
In brief, 10-fold serial dilutions of a virus stock were prepared in triplicate and inoculated onto a monolayer of RD cells.
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PMC9884169
These results further showed that the AMPK agonist A-769662 significantly inhibits the elevated ROS levels caused by knockdown of MCT4 (Figure 3(b)) and the level of lipid ROS in the cells with knockdown of MCT4 (Figure 3(c)) in 5637 cells.
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PMC11128598
However, we demonstrate that ROS generation plays a critical role in CQ/LBH-induced lethality in the different tumor cell lines analyzed, especially in the breast cancer MDA-MB-231 and in the glioblastoma A-172 cell line.
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PMC7039683
All three core fragments lie 8.5 kb (human), 4.0 kb (mouse), and 10.4 kb (zebrafish) upstream of ppl, which is transcribed to the left in each case.
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PMC2777936
These experiments did not reveal a substantial loss of the pluripotency-associated antigen SSEA-3 or gain of the neuronal specific antigen A2B5 (data not shown).
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PMC9429973
42 of them were male and 18 females, with an age range between 30-65 years old.
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PMC9429973
Although it is known that cytogenetic abnormalities are seen in approximately half of children diagnosed with MDS, their detailed cytogenetic profile has not been elucidated yet due to the rarity of the disease.
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PMC11806106
To gain information on the velocity of activation-induced conformational changes of the MOR by different agonists, we performed single-cell measurements of the MOR FRET sensor at a microscope.
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PMC11591052
The latter are a well-characterized model of immortalized mouse myoblasts that help interpretation of the results obtained at the molecular level in the context of muscle function and repair.
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PMC11790971
The area and shape features were kept the same among all subsets of imaging modalities since they were calculated from the cell masks that were shared by all image channels.
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PMC10858941
However, there is no information about the effect of NNC on the different regions of the microenvironment present in heterogeneous tumours such as GBM, partly due to the limitations of conventional in vitro models recapitulating the intricate and dynamic in vivo landscape of the tumour microenvironment .
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PMC9429973
At 3 month post-RM-001 infusion, total Hb exceed 110 g/L in both patients, with 97-98 g/L HbF. Approximately 89% peripheral erythrocytes are F-cells at 3 month post-RM-001 infusion (Figure).
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PMC11206251
Furthermore, apoptosis was evaluated by flow cytometry, and gene expression and the regulation of signaling pathways were investigated, respectively, by real-time fluorescence quantitative PCR (RT-qPCR) and western blot.
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PMC11753435
Clarified lysates containing 6×His-tagged proteins were subjected to gravity-flow nickel-affinity purification using HisPur Ni-NTA resin (Thermo Fisher Scientific, 88223) following the manufacturer’s protocols.
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PMC11723947
Gene set enrichment analysis (GSEA) confirmed these results and further associated this gene set with Th17 cell-dependent immunity (Figure.
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PMC11543885
Wash the beads as described in step-24 but with the following reagents in this order: once with 1 M KCL, 0.1 M Na2CO3 and 2 M Urea (in 10 mM Tris-HCL, pH 8) and finally twice with RIPA buffer again.
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PMC6835428
Comparable results were obtained using cisplatin in place of PTX.
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PMC11740207
Research into the therapeutic application of NDSCs has revealed their potential for treating neurological disorders, autoimmune diseases, and cancer by targeting damaged tissues and supporting cellular regeneration (Lee et al., 2014).
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PMC6267596
The generation of drug-induced aneuploid/polyploid (DIAP) cells is a common effect of anti-DLBCL therapies (e.g. vincristine, doxorubicin).
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PMC11391695
Furthermore, flow cytometry analyses demonstrated a significant increase in the number of SMMC-7721 and BEL-7404 cells that underwent apoptosis when treated with si-KCNN4.
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PMC9964654
The HPLC chromatograms show that the free gold complexes and the gold complexes collected from the loaded micelles exhibited similar profiles, with single peaks at similar retention times, suggesting that the gold complexes maintained their chemical structures unaltered.
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PMC7504302
Moreover, oncogenic mutations in ABL1, EP300, PIK3CA, PIK3C2B, PTPN11, and SETDB1 genes , and novel gains in regions encompassing RHEB, KDM5A, AXIN2, RICTOR, TRIO, and DVL1 genes were identified .
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PMC11545737
Calpain-dependent cell rupture was dispensable for IL-1β release but required for the release of mitochondria and bacteria .
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PMC10440586
Gliomas recruit immunosuppressive cells including tumor-associated macrophages (TAMs), facilitating their immune escape .
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PMC9351137
B Histograms showing the fluorescence intensity of immunostaining in RNAi-treated and mock-treated cells.
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PMC3765139
Within GeneSpring® raw data were preprocessed including background adjustment, normalization, and summarization of probe sets, using the GeneChip® Robust Multiarray Analysis (GC-RMA).
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PMC11743414
5Study of the effect of FHL1 on apoptosis of HL60 cell lines under drug treatment.
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PMC11748335
We further calculated the proportion of OGs in long LOCKs within S/I/L-PMDs.
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PMC11411131
This toxicity could occur in addition to the reduction and direct modification of full-length TrxR1, even upon exposure to low concentrations of MeHg.
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PMC3122064
Nutlin-3 even showed protective activity in normal kidney cells against cisplatin-induced apoptosis.
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PMC9429973
Peter MacCallum Cancer Centre.
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PMC6337547
Phenolic acids in Salvia species exert anti-hypertensive effects , improve memory and cognitive impairment , possess hypoglycaemic and antiviral activities , and can be used to prevent and treat cataract .
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PMC11521786
Three prostate human cell lines—PC3 (CRL-1435), DU 145 (HTB-81), and LN-Cap (CRL-1740)—along with the human cell lines derived from NSCLC, H1975 (CRL-5908), and SKBR3 (HTB-30, isolated from a breast adenocarcinoma), were obtained from the American Type Tissue Culture Collection (ATCC).
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PMC7961460
Aliquots containing equal protein concentration were mixed with 1 volume of reducing sample buffer, denatured and separated by SDS-PAGE, followed by transfer to nitrocellulose.
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PMC10213199
Canton S Drosophila were raised at 25 °C and 60% relative humidity in a 14/10 h light/dark cycle on a standard Drosophila medium (water, cornmeal, agar, molasses, yeast, and nipagin).
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PMC11730311
In this present study, we used the streaMLine platform to explore lipidation in hαCGRP peptide-based migraine therapeutics.
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PMC11762280
However, we did not delve into how ZBP1 is regulated and initiates PANoptosome assembly in keratinocytes after UVB irradiation in this study.
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PMC11407042
Transfer cells to two or more dishes if necessary.
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PMC11127909
The data are presented as the means ± SEMss; *P < 0.05, **P < 0.01 CATR enhances the efficacy of cisplatin in vivo.
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PMC11783017
In the past 40 years, there has been no substantial improvement in the 5-year survival rate of OS.
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PMC11723947
It then aligns reads to the Ensembl GRCm39 genome and annotation v.107 using STAR v.2.7.10a.
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PMC11541409
Annals of Oncology, 2022.
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PMC11748335
Upon analyzing the proportions of the three groups of LOCKs in S/I/L-PMDs, we found that tumor-loss LOCKs dominated the S- and I-PMDs.
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PMC9429973
Thus, we performed a meta-analysis based on previous cardinal studies to investigate the collective and gender-specific distribution of variant allele frequencies.
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PMC11656380
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignant tumor characterized by the abnormal proliferation of immature thymocytes.
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PMC6442998
αSMA protein was undetectable in GIST882 cells but abundant in GIST48 cells.
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