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OTAR3088
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PMC11552389
The formed colonies were then fixed with 4% tissue fixative for 15 minutes, followed by staining with 1% crystal violet solution for an additional 15 minutes.
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PMC11774251
Subsequent Tan-I intervention further identified 494 DEGs compared to the CON group.
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PMC8922418
Given the two known cases of the "Berlin Patient" and "London Patient", the co-receptor CCR5 also should be an ideal target for HIV-1/AIDS gene therapy.
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PMC11666785
Alongside, mean localization precision with #frames / blinking time is also shown.
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PMC11752740
Results are presented as Mean ± SD compared to control Effects of varying concentrations of pistachio hull extract and carfilzomib (CFZ) on the growth of SK-BR3 and MCF10A cells over 24- and 48-hours.
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PMC10898159
IPI-504, IPI-493, TAS-116, AT13387 and NVP-AUY922 are HSP90 inhibitors.
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PMC11641532
Tumor driver genes are those that play a role in tumor initiation and progression by promoting cell proliferation, survival, and metastasis .
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PMC11467964
Initially, we interfered with PSAT1 expression by transfecting siRNA and verified the knockdown efficiency by PCR.
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PMC9429973
20 Patients received 60 mg/die of elemental iron of Sucrosomial® iron (20 patients – group A).
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PMC7757104
The protumorigenic functions of the PI3K/AKT pathway also involve the regulation of survival and apoptosis inhibition, which are associated with drug resistance in ovarian cancer cells (31,32).
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PMC11640555
In the context of GBM, the most studied neurotrophins are NGF and NT-3 , whose interaction with its specific receptor present on the surface of tumor cells, Tropomyosin-related kinase A and C (TrkA) (TrkC), respectively, could contribute to tumor aggressiveness.
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PMC11802855
P < 0.05, **P < 0.01 and ***P < 0.001 were noted.
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PMC10813895
The Cancer Genome Atlas data analysis reveals generally low ELF5 expression in luminal A/B BCs, with exceptions of higher expression in some cases .
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PMC10873328
The protein expression level of TGFBI after time gradient of cisplatin in A2780/CDDP (IC50 as 258.8 μM). (
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PMC11803149
Taken together, these results suggest that decreased expression of Epas1 impairs anti-tumor activity of CD8 TCR-T cells in ACT, which can be improved by expression of exogenous Epas1.
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PMC7171147
c, d Western blot of pAMPK (T172) in ES2 cells expressing either scrambled or shDDR2 (c) and shITGA1 (d) cultured on either in PBS or COL11A1-coated plates for 48 h. GAPDH was used as a loading control.
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PMC11448304
KEGG annotation of up/down-regulated groups revealed signal transduction, signaling molecules and interaction, and immune system were the most enriched (Fig. 2c, Supplementary Fig. 1a).
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PMC3164356
The only N-glycan-modifying fucosyltransferase expressed in CHO-K1 is FUT8, which adds fucose to the core glycan by an α(1,6) linkage. (
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PMC11637284
Fig 4D shows a pulldown assay in which TAC60ΔC283-myc was used as a bait.
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PMC9895440
Both gene-specific Alt-R-crRNA and Alt-R-tracrRNA were mixed at 200 μM in nuclease-free duplex buffer (IDT) and heated to 95 °C for 5 min, then cooled to 25 °C at −0.1 °C per minute.
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PMC7917457
Intratumoral administration of PeptiCRAd significantly increased tumor-specific T cell responses, reduced tumor growth, and induced systemic anti-cancer immunity in two mouse models of melanoma.
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PMC10253553
The reduction in phospho-NDRG1 (Thr346) due to the inhibition of mTORC2 corresponded with a decrease in the percentage of live cells, which was correlated with an increase in apoptosis.
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PMC11481779
As the human model is trained on GM12878 data (which is lymphoblastoid cells), we have decided to use a similar cell line in mouse.
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PMC11705484
H, J) Ultra‐high‐performance liquid chromatography‐tandem mass spectrometry (UHPLC–MS/MS) assays were performed to detect and quantify mA levels in total RNA from 5637 and T24 cells. (
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PMC11756907
The reaction mixture was heated to 35°C and then stirred for several hours.
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PMC11661040
For overexpression experiments, MG63 and 143B cells were transfected with the pcDNA3.1-EGFP-P2A-CGREF1-3FLAG plasmid using Lipofectamine 2000.
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PMC9429973
Image: Summary/Conclusion: IDA is a common extraintestinal manifestation of Crohn’s disease.
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PMC11476837
In this study, we have addressed the impact of NRF2 inhibition on overcoming doxorubicin resistance in HL-60/DR cells.
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PMC9429973
This survey reveals the difficulties of youths to consider the risks of hereditary transmission of thalassemia and to understand the importance of screening and genetic counseling.
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PMC9429973
Distribution of cases according to different subtypes is reported in Figure 1.
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PMC3164356
When compared to human, mouse and rat, the distribution of CHO GO class assignments shows significant coverage (that is, >50% of the instances in mouse and significantly enriched, P < 0.01) of classes involved in translation, metabolism and protein modification (Fig. 2).
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PMC11049548
Cancer cell lines are frequently used in metabolomics, such as in vitro tumor models.
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PMC11300085
Therefore, only SK-OV-3 cells were used for the subsequent experiments.
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PMC11612626
To process antigens more efficiently, the three constitutive proteasome catalytic subunits (β1, β2, and β5) are replaced with specialized catalytic subunits (β1i, β2i, and β5i), which are cooperatively incorporated to form immunoproteasomes (6, 7).
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PMC11721587
Right, Flag-tagged kinase dead Fu (Fg-Fu) purified from Sf9 cells was subjected to in vitro kinase assay by FuN and CK1, followed by in vitro SUMOylation assay in the presence or absence of SUMO1 for the indicated periods of time.
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PMC11591038
Several well-known HIF-1 target genes including EPO, VEGF, and PDK1, which encode erythropoietin (EPO), vascular endothelial growth factor (VEGF), and pyruvate dehydrogenase kinase-1 (PDK1), are critical for the production of red blood cells, formation of blood vessels, and oxidative phosphorylation in the mitochondria...
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PMC9325715
The results for cytotoxicity evaluation are presented in Fig. 6.Figure 6Cytotoxic effect of iron citrate and complex of Fe-bLTF in L929 and Caco-2 cells detected with the MTT reduction assay (values are expressed as a percentage of cell viability) and LDH release assay (values are expressed in mU/mL).
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PMC7338939
Based on the measured killing factor for the 2nd, 4th, 8th, 9th, and 10th animals, it was clear that DAPT was not a good choice for therapy.
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PMC11612626
Overall, compound A treatment enhanced the presentation of HLA-B and respective subtype alleles.
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PMC4695073
Peroxidase Envision Kit was from Dako (Carpinteria, CA, USA).
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PMC9429973
Results: The median age of the 38 patients was 25 years (6-59 years), including 21 males and 17 females.
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PMC11803918
A,B) Representative CLSM images and quantification results of CRT exposure on the A375 cells after different treatments with or without light irradiation (scale bar: 50 μm; blue: DAPI, green: CRT). (
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PMC7039683
GSEA for genes expressed in GFP-positive cells using EVL gene set (www.zfin.org). (
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PMC9429973
Pts who completed the FDP of ACTIVATE/ ACTIVATE-T were eligible to continue in the LTE, where all received mitapivat.
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PMC11588085
Notably, XIST is predominantly expressed in epithelial cancer cells (29.08%), endothelial cells (66.09%), and fibroblasts (47.59%), while CD44 is less expressed in these cell types (14.26%, 2.10%, and 7.36%, respectively) but is highly expressed in immune cells (37.09%) compared to XIST (13.36%).
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PMC9268183
We want to stress, however, that our efforts to collate and make such data available should be paralleled by an increase in pharmacological studies to experimentally validate the data reported here, and also by subsequent analyses regarding the impact of these chemicals on cancer cell lines.
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PMC11781181
In vivo, IHC revealed significant ALOX15, ACSL4, and LPCAT3 upregulated expression in SJS/TEN skin lesions.
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PMC11604830
To investigate the imaging potential, a phantom was prepared for each nanosystem, containing serial dilutions of the nanocarriers in agar gel.
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PMC11530949
From a therapeutic perspective, metal NPs have demonstrated efficacy in cancer treatment through mechanisms such as drug attachment, hyperthermia-induced cancer cell death, and modulation of autophagy and mitophagy processes in cancer cells (24).
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PMC8777939
Extracellular AGR2 induces angiogenesis by binding to VEGF-A and FGF2, thus leading to migration and metastasis in cancer .
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PMC9587298
The MS spectra of these newly formed compounds further support the presence of one or two MGO adducts.
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PMC11790971
Briefly, a 10 MHz, 1040 nm pulsed fs laser source (FemtoTrain, Spectra-Physics) was used to pump a photonic crystal fiber (LMA-PM-15, NKT Photonics) to create a broad supercontinuum.
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PMC9250505
C Western blot (PDO1): western blot analysis of ascitic fluid cancer (AFC) cell-derived organoids (also designated as PDO-1) in 3D Matrigel after treatment with NPB (N) alone or in combination with Olaparib (O), Rucaparib (R) or Talazoparib (T).
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PMC11746942
The discrepancy of S1PR1 expression in IMQ-induced mice and psoriasis patients was observed in our study.
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PMC11015054
The cDNA was synthesized using the PrimeScript RT Reagent Kit (Takara, Cat: RR037A, Dalian, China), followed by detection using TB Green Premix Ex Taq (Takara, Cat: RR820A, Dalian, China) on the ABI PRISM 7500 Sequence Detection System (Applied Biosystems, Inc.).
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PMC11469524
In HBL-1 cells additional links from JNK/cJun to AKT and from AKT to p90RSK were required, whereas in OCI-LY3 the network required a link between JNK/cJun and GSK3 and between IKK and AKT for optimal fits.
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PMC11502443
To allow direct comparisons between the receptors the operational model was performed on data normalized to the maximal response produced by GIP (1-42) at the WT GIP receptor, for both the WT and E354Q GIP receptor.
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PMC11794847
Sequencing results showed that GATA1 could interact with HVEM promoter region, as indicated in Figure S12A.
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PMC11770746
The lipid film was then hydrated with 1 mL of PBS by rotating at room temperature for 30 min without vacuum, followed by overnight incubation.
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PMC10419319
However, despite the favorable initial response, most patients develop resistance to cisplatin after repeated exposure .
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PMC11155445
Reduction of the nitro group occurs through intermediate N-hydroxylamine (Fig. 23).
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PMC11599565
This effect is also partially observed in cells treated with cisplatin maintained in Neuropan induction medium, though notably Notch1 expression is significantly reduced.
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PMC9429973
Aims: To evaluate the clinical/immunological features and genetic profile of patients with MF carrying CARD11 variants and followed in our Centre.
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PMC11496728
Viable cell density; (B) cell viability.
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PMC11583010
This time corresponds to the ex vivo hydrolysis of the maleimide.
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PMC10667689
As metabolic inhibitors are among the promising therapies for AML, and several clinical trials are exploring the effect of TIM-3 blockade in AML patients, we investigated the role of TIM-3 on glucose and lipid metabolism in two AML cell lines.
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PMC11687663
After passing through the initial lipid layer, a new energy barrier must be overcome before reaching the subsequent lipid layer.
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PMC9429973
In patients with ALL and confirmed coronavirus infection, the decision to conduct induction therapy should be discussed on an individual basis, depending on ALL status, the activity of coronavirus infection and comorbidity status.
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PMC9429973
Bacteriemia was identified in 18 patients: 7 cases of gram-positive and 11 of gram-negative.
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PMC11519077
IBD is treated with anti-integrin antibodies, antitumor necrosis factor, and immunosuppressive drugs such as methotrexate, 6-mercaptopurine, and azathioprine .
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PMC11721295
Multiplex ELISA (Luminex) assays were performed on TCM and CAF CM.
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PMC11802929
We depicted key physicochemical properties identified earlier on radar plots, revealing a significant shift in overall characteristics between PG-TCR groups (Fig. 6c, Supplementary Fig. 9a).
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PMC11765988
Since lymph nodes are the most common site of sarcoidosis involvement, oxidative stress might preferentially affect lymphocytes, thus connecting sarcoidosis and lymphoma.
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PMC9268183
Certainly, as already stated by Brower , unless action is taken, the rapid loss of biodiversity (to which we add the decline in traditional knowledge, particularly in heavily-industrialised societies) can adversely affect future cancer plant-based drug discovery.
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PMC9429973
Variables were compared within Tx arms (LTS vs non-LTS) in univariate analyses with P values corrected for multiple testing.
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PMC11706776
These results highlight a potential oncocomplex involving SK1 and calcium channels that may promote the proliferation of Ewing sarcoma.
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PMC9429973
Median (interquartile range) recovery times were 30 days (22, 34.5) to neutrophils ≥500/μL and 21 days (21, 27) to platelets ≥50,000/μL. Complete remission (CR) or CR with incomplete neutrophil or platelet recovery (CRi) was achieved by 16/28 (57%) patients with an evaluable remission assessment.
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PMC9847912
However, for both of the assay methods used in our study, the conditions used to dose, infect, and culture the cells were consistent across the entire range of isolates tested, thereby providing an unambiguous comparison of HIV-1, HIV-2 and SIV isolates with respect to GSK232-mediated antiretroviral activity.
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PMC9429973
Complex karyotype、hemoglobin、pre-HSCT MRD were also risk factors for relapse (p=0.038,p=0.02,p=0.023),besides,pre-HSCT BM blast% also have an impact on relapse,p=0.027.Among the 42 patients, 12 patients (28.5%) with complex karyotype, including 2 patients with TP53 deletion alone (16.6%), 5 patients with TP53 single mu...
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PMC11596967
This interaction leads to water radiolysis, resulting in the formation of highly reactive species like hydroxyl radicals that cause extensive damage to essential biomolecules such as DNA, lipids, and proteins .
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PMC9429973
In follow-up sequencing at around Week 24, of 60 mutant alleles in 32 patients, the mean MAF fell by 39% in 48%.
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PMC11243198
In this study, GANT61 and its active form GANT61-D were used as scaffolds to identify closely related compounds that may have improved potency and drug-like properties.
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PMC7153288
ND: not determined.
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PMC11437637
P < 0.05 (in bold) was considered to be statistically significant Abbreviations: PSM Propensity Score Matching, NK Natural Killer cells, NKT Natural Killer T cells, PBL Peripheral Blood Lymphocyte, EC endometrial carcinoma Comparison of PBLs in patients of endometrial carcinoma and uterine fibroids (≥55 years old) Note...
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PMC11730311
In addition, a comprehensive amino acid mutational scan was performed on a selected lipidated hαCGRP8-37 analogue to identify amino acid substitutions which further enhance potency against the hCGRP-R. Work involving use of animals compiled with the ARRIVE guidelines.
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PMC11406030
There is no commercially available docetaxel-resistant A2780 cell line.
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PMC10761571
Newly, carbohydrates, as biomimetic functional molecules, have gained interests to be used for surface functionalization nanoparticles.
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PMC11628904
Analysis of macrophage recruitment to sterile burn injury revealed a significant difference during the period of wound remodelling, 24 hpb, with control larvae having 50.0 ± 2.5 macrophages compared to only 21.1 ± 2.1 following isotonic treatment (Figure S2C,E).
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PMC11286266
Both 2K-parental cells and 2K-CRT∆ derivative cells were cultured in 10-cm dishes for 2 days and then treated with 2DG (4 mM) for 3 hr before harvested.
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PMC11185260
N = 4–5/group. (
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PMC11365427
Overall, targeting phenylalanine metabolism provides a promising avenue for further investigation of MM treatment strategies.
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PMC11719944
There were no significant differences in the percentages (Figure 4a,b) or absolute numbers (Figure 4c,d) of follicular T cells between the two groups.
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PMC9429973
Regarding molecular biomarkers, NPM1, RUNX1 and ASXL1 mutations, FLT3-ITD (internal tandem duplications), CEBPAbi or KMT2A-PTD (partial tandem duplications) have been shown to have clinically significant prognostic value and they define specific AML disease subtype.
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PMC10565698
Wild-type (WT) and mutant (MUT) circUSP10 and TCF12 plasmids carrying the binding sites for miR-211-5p were designed and synthesized.
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PMC11519567
B Representative images of BJ fibroblasts expressing SS18-EGFP and SS18-SSX1-EGFP for immunofluorescence detection of H2AK119ub after 3 h treatment with DMSO and 37.5 μM PRT4165.
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PMC11803149
A-C) Data are representative of 3 (A) or 2 (B, C) independent experiments.
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PMC10440586
Through metabolic reprogramming and angiogenesis, gliomas adapt to low oxygen content .
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PMC11519077
On a microplate reader (Biokit ELx800 Reader, Spain), the optical density (OD) of the formazan was determined at 570 nm wavelength.
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PMC11718817
Our own work has shown that myeloid cells act as bridging cells to transmit suppressive signals from Tregs to CTLs in an antigen-dependent manner .
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PMC11449273
A one mL aliquot of PG-GST bacterial lysate was incubated with 150 μL of glutathione sepharose beads (GE Life Sciences) on a rocker-rotator at 4°C for 6 hours.
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