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OTAR3088
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BioData-CellLine_annotated

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PMC11753435
Calculated P values are represented as follows: *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; ns, not significant. (
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PMC11590870
The above is reflected in a reduction in cellular fluorescence.
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PMC11536589
Additionally, we subcutaneously injected MRTX1133-sensitive KPC210 cells into nude mice, demonstrating tumor inhibition by MRTX1133 alone without observing significantly synergistic effects with PKF-118-310 (Fig. 7H).
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PMC11741577
In mouse skin wounds, VEGF-A enhances angiogenesis, wound surface epithelialization, and collagen synthesis .
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PMC10919056
The results showed that the expression of GJA5 and GJB1 in normal tissue of ccRCC was significantly higher than that in tumoral tissue.
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PMC9100622
We demonstrated such an altered anchorage for RAC1, RHOA, and RAS, but the anchorage of many other membrane receptors, including GPCRs and growth factor receptors that play a role in the transduction of proliferation signals, is also expected to be impaired.
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PMC5916734
In the main producer cell line, 3B12-86, we assessed the changes in the expression levels of several of the housekeeping genes involved in the biosynthesis and post-translational processing of proteins by RT-PCR (Fig. 3 C).
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PMC11740207
This approach allows for identifying disease mechanisms, testing potential therapies, and understanding genetic contributions to diseases.
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PMC9429973
We screened their efficacy in vitro alone or combined with chemotherapic (Arabinoside) and biological agents (Venetoclax) by using AML ex vivo cells and mesenchymal stromal cells in a 3D co-culture system for exploring their synergy in reducing AML proliferation.
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PMC9429973
Recommendations on the use of these two drugs vary, some recommend its use only in severely immunocompromized individuals, some only in serious cases and some not at all.
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PMC11457557
CETP polymorphism is a substantial and independent risk factor for atherosclerotic vascular disease, and it plays a vital role in the metabolism of HDL, which controls absorption of cholesterol by hepatocytes.
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PMC11281366
Our results show that miRNA-26a expression levels are decreased in CD4 T cells upon HIV-1 infection, and we provide evidence that this reduction requires the integration of the viral DNA into the genome of target cell, as well as the expression of HIV-1 genes (Figure 7).
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PMC9429973
As with other cancers, cell cycle dysregulation leads to the progression of MM, where CDK4/6 disorders are common.
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PMC9429973
The determination of the relative number of tumor cells expressing p16, p53 was carried out using immunohistochemical and morphometric methods.
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PMC11765988
Additionally, cases have been reported in which sarcoidosis coexists with lymphoma, presenting as a paraneoplastic syndrome .
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PMC9429973
The most frequent comorbidities were hypertension in 20% and diabetes in 9,4%.
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PMC11496728
PCR amplification results of Apaf1 knockout monoclonal cell line of CHO cells, the PCR amplification products of clone 1 and clone 2 were about 500 bp, and the PCR amplification products of clone 3, 4 and 5 were about 300 bp, which matched the primer length designed in this experiment; (B) comparison of the relative mR...
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PMC10154097
circSOX4 is upregulated in lung cancer and plays the role of oncogene.
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PMC9429973
Two patients discontinued romiplostim before Week 27.
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PMC11033180
In total, 6 culture wells from 3 experiments were analyzed.
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PMC11351758
The glycation of extracellular proteins ensues when there is an abnormally high concentration of glucose, such as in cases of diabetic hyperglycemia .
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PMC9429973
Summary/Conclusion: Patients with AFVI presenting with hemorrhagic manifestations should be treated aiming for hemostatic control as well as inhibitor eradication.
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PMC11240571
The cPD-L1 level and release of exosomal PD-L1 increased after RT irradiation.
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PMC11727145
Moreover, the standardized method of preparation of the DED was then assessed with H&E staining, and histological structural controls for quality between lots could be confirmed.
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PMC10667689
The concentration of GSH was increased at 48 h after treatment with Gal-9 compared to the PMA and control group in both the THP-1 (A) and HL-60 (B) cell lines (***p < 0.001).
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PMC11750696
As the UPR is crucial for the efficacy of T cell functions, as previously discussed, strategies targeting UPR-related molecules in T cells might offer protective effects against SLE.
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PMC6803987
A ~ F. The elution fraction (9:1, CHCl3–MeOH) was separated by MCI column chromatography, decolorized by 90%, and separated by gel column.
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PMC11746948
The lentivirus supernatant was collected 48 h after transfection and filtered.
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PMC11706776
C Cell cycle assays on shRNA 908 cells treated (shRNA 908 +Doxycycline) or not (shRNA 908 −Doxycycline) with doxycycline 0, 6, 8 or 10 h after thymidine double block.
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PMC11200978
These results suggest that the synergy between cryoablation and chemotherapy may offer enhanced efficacy in targeting NSCLC, thereby potentially expanding the therapeutic window.
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PMC9429973
6 months from the start of co-housing, the bone marrow of co-housed mice and age-matched wildling mice was analyzed using flow cytometry, and HSC function was assessed by competitive bone marrow transplantation assays.
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PMC11155445
The preparation of solid-state Pb2+-ion selective electrodes based on PVC and liquid membranes using three 1-aroyl-3,3-disubstituted thioureas as ionophores was reported by Lazo-Fraga and coworkers.
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PMC10607604
The indicated chemotherapeutic drugs in the fresh medium were then added for 72 h. Living cells were quantified using the CellTiter 96 Aqueous One Solution Cell Proliferation Assay (Promega).
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PMC11592837
In contrast, fragments > 250 bp are preferentially formed in tumor cells because of necrotic cell death caused by an active suppression of p53-mediated apoptosis .
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PMC9985266
Compared with the BLM group, HE staining results showed that alveolar septum thickness was reduced, alveolar inflammation was reduced and fibrosis was alleviated in the IL-27 group (Additional file 1: Fig. S2A).
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PMC11473750
After 3 washes of PBST for 5 min each, secondary antibodies, Alexafluor 594 anti-mouse (to detect Myc) and Alexafluor 488 anti-rabbit (to detect organelle marker), were applied at a dilution ratio of 1:500 and incubated for 45 min at room temperature.
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PMC11635519
G-Protein-coupled receptors (GPCRs) make up a large superfamily of cell surface receptors.
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PMC10545062
The left axillary artery was surgically exposed and cannulated for proximal blood pressure (BP) measurements.
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PMC9780037
The relevance of cyt c quantification in patient serum has encouraged the development of innovative approaches for highly sensitive cyt c quantification in biological samples, which will be described in the following section. (
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PMC11568601
The increased expression of BAX protein and decreased expression of BCL-2 protein in TGT treatment group further validated the results of the phenotypic data (Fig. 3C).
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PMC9429973
Both hematological response and renal response were assessed by International Myeloma Working Group (IMWG) criteria.
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PMC10213179
Primary tumors and lungs were fixed in 4% buffered paraformaldehyde for histopathological analysis.
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PMC10798140
As a result, increasing the variety of the substitution resulted in comparable cytotoxic activity to sorafenib, by occupying a distinct chemical space.
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PMC9429973
Using the bulk analysis such as WGS, WES, or genomic array to precisely determine the co-occurrence of aberrations in the individual cell provides limited information.
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PMC11684269
Accordingly, the patients with tubulointerstitial fibrosis exhibit lower expression of key enzymes and regulation in FAO compared to healthy individuals, and the subsequent in vivo and in vitro experiments also corroborated with this conclusion (95).
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PMC9429973
Summary/Conclusion: Using a combination of CRISPR/Cas9 screening and ligand-induced degradation, we identified direct transcriptional target genes of NUP98-KDM5A that are functionally essential in AML.
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PMC10093184
The inserts containing migrated/invaded cells were fixed in 70% ethanol for 10 min at room temperature.
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PMC9516401
Statistical analysis The experimental data were analyzed using GraphPad Prism (GraphPad 7, San Diego, CA, USA).
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PMC11774112
The data in B are expressed as the means ± SDs (n= 6). (
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PMC7685376
To remove urea, samples were centrifuged by adding 100 mM TEAB three times.
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PMC11574029
L Wound healing assay assessing the migration ability of T24 and 5637 cells after NOTCH3 knockdown.
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PMC11611077
The cumulative cell area and intensity of each clone were measured.
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PMC11711663
Table 2Selected features by familiesGradientWaveletLog.3DSquarerootExponential1.
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PMC9429973
Grade 4 neutropenia was reported in 150 patients who had a high level of C-reactive protein (median=115 mg/L), a significantly elevated D-dimer (median = 912 ng/mL) and fibrinogen (median=6.5 g/L) levels.
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PMC9429973
The primary outcomes were comparable between eltrombopag and rh-TPO group.
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PMC9429973
Results: AML patients with low NLR (<2.0) had a longer OS than those with high NLR (≥2.0).
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PMC9250505
To confirm the functional specificity of NPB directed to BAD, CAOV2 cells were treated with NPB after siRNA-mediated depletion of BAD expression (Supplementary Fig. 3A).
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PMC11753949
The spine apparatus and the cisternal organelle are two specialized subdomain of the ER that share morphological features and require the actin binding protein synaptopodin for their formation.
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PMC11578343
Outlier identification and removal was performed for data points that fall below Q1 – 1.5IQR or above Q3 + 1.5IQR.
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PMC10495912
Cell culture The HepG2 cell line was obtained from the Iranian Biological Resource Center, Tehran, Iran.
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PMC9105697
Quantity of cfDNA was determined by Qubit 3.0 Fluorometer, using a high-sensitivity Qubit dsDNA HS Assay Kit (Invitrogen, Carlsbad, CA, USA).
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PMC7192625
As expected, we found all modifications to be significantly assortative with respect to random, as these marks are associated with chromatin states that are known to be attracting each other, such as active chromatin, making contacts within the active compartment, and heterochromatin and polycomb domains, also making p...
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PMC9429973
Seven out 13 were treated with lenalidomide and achieved a major erythroid and cytogenetic response.
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PMC11656657
At the time of tumor engraftment, 10 effector T-cells were administered through i.v.
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PMC5417661
All mice were housed under strictly controlled and standardized barrier conditions (22°C±1°C temperature, 50%±10% relative humidity, 12 h light/dark rhythm) in individually ventilated Macrolon Type-II cages (Techniplast S.p.
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PMC11397654
The effect of using a 36-methotrexate complex for cancer treatment was also assessed during in vivo studies using 4T1 tumour-bearing mice.
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PMC10933092
Next, Lasso-Cox regression analysis was performed on mRNAs and lncRNAs differentially expressed in sh-NC and sh-TRMT61A 5637 cells to construct a risk score for predicting overall survival.
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PMC6892818
Bars show mean % DNA fragmentation of six technical replicates ± SEM.
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PMC6901583
A further attempt to decipher the role of NF-κB was to pretreat cells with an inhibitor of NF-κB, BAY 11–7082, that prevents translocation to the nucleus (Fig. 6c).
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PMC6190245
In a study on 19 human cervical cancer cell lines, Britten et al. discovered that when radiotherapy is co-administered with cisplatin, the death rate of these tumor cells increases (Britten et al., 1996).
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PMC9429973
Aims: The data for generic Elthrombopag in severe aplastic anemia (SAA) is lacking, we aimed to study the efficacy and safety of generic Elthrombopag in immunosuppressive therapy regimen in SAA.
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PMC9275501
In vivo pharmacokinetic study, DTX and CUR showed a synergistic ratio of 1:2 throughout the cycle.
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PMC11720107
However, we could not definitively identify which polyphenol or how it is involved in PPARγ activation.
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PMC11522251
Research has shown that p-STAT3 may be a useful predictor of how well anti-EGFR treatment works for patients with colorectal cancer .
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PMC10631132
This was followed by evaluating mesodermal differentiation and characterization of hematopoietic progenitor cells produced under the differentiation strategy.
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PMC9429973
At present, at least 23 genes have been discovered to play a role in the FA pathway.
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PMC11734514
Concurrently, the invasion assay had a significant decrease in the number of A549 cells capable of traversing the matrigel membrane, reaching 22.80% (Figure 5A and B).
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PMC6337547
The antioxidant effects of phenolic acids involve three processes: free radical scavenging, inhibiting free radical generation, and anti-lipid peroxidation .
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PMC11365427
Serum calcium is a crucial indicator of bone metabolism and reconstruction.
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PMC8526701
The downregulation or inhibition of BRD9 could significantly reduce cellular proliferation, and facilitates apoptosis in GISTs.
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PMC10237474
10 μL of Lipofectamine LTX was diluted in 0.5 mL of Opti-MEM media.
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PMC10079526
Pearson r and P-value.
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PMC5941560
This gave an average coverage of ∼ 36x across the hg19 reference sequence, with over 10x depth of coverage for 78.8% of the genome.
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PMC10174970
The top 3 poor consistency PAAD cell lines with tumor tissue were all cell lines of metastatic lesion in several cancer-related pathways, such as endometrial cancer, renal cell carcinoma, and small cell lung cancer.
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PMC11736898
The results support the investigation of CYP24A1 as a potential therapeutic target for suppression of keloid pathology.
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PMC11779605
In contrast, the parental ID-8 cell line produces slow-growing tumors that lack the characteristic mutation profiles of HGSOC (19).
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PMC11531744
The GV298 lentiviral particles consisting of GBP1P1 shRNA sequence (5′-GCCAAGTCTG GTCACTAAACT-3′) were designed and synthesized by Jikai Kiin Technology Co. LTD (Shanghai, China).
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PMC3730428
FLIP inhibits apoptosis through binding to FADD and blocking caspase 8 activation in Complex IIa and IIb.
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PMC11768927
Combining VSV with pharmacological inhibitors of IFN signaling can mitigate oncolytic resistance in cancer cells.
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PMC3122064
Downregulation of p21 (Supplementary Figure 3e) led to an increase in Nutlin-3-induced apoptosis (at 4 μM) in Scha and 2102EP cells, as demonstrated by an increase in PARP cleavage (Supplementary Figure 3e).
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PMC11770130
At last, PCR products were purified (AMPure XP system) and library quality was assessed on the Agilent Bioanalyzer 2100 system.
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PMC11286266
The functionality of this probe was confirmed by treatment with DTT that resulted in the appearance of a prominent faster migration band in sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS–PAGE), compatible with the processed S2P-cleaved ATF6α (N-ATF6α) form, and depletion of the precursor form (ATF6α-P) ...
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PMC11742431
As shown in Figure 3A, at 2 h, the surface of 5637 cells was covered by green fluorescence, and dotted fluorescence could also appear within the cells, compared to 0 h. With time increased, the brightness of the fluorescence on the cell membrane gradually decreased, whereas the intracellular punctate fluorescence gradu...
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PMC11756514
S. aureus JE2 WT, ΔtarS, ΔtarM, ΔtarMS, and ΔtagO were cultivated and labeled with FITC as described above.
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PMC11604830
In (D, E) confocal microscopy images of (D) the left PLN and (E) the right one are displayed: Blue corresponds to nuclear staining (DAPI), while red corresponds to the rhodamine signal (PFCE‐NE).
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PMC11593084
In contrast, NZ-1 showed the reactivity to both 293FT and PODO/TERT256 (Figure 1C).
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PMC11286266
The bar graph shows the mean ± standard error of the mean (SEM) of the normalised median BiP::sfGFP reporter intensity from three independent experiments.
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PMC11572213
Cell counts were decreased in both control and TET2-downregulated cells in glutamine-deficient medium (Figure 3).
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PMC11188874
While immunoprecipitations were performed using a pan-MHC-I antibody (W6/32), the eluted peptides were selectively increased for those cleaved by proteasome ChT-like activity.
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PMC11785489
We next benchmarked our TCR scoring functions against existing TCR metrics.
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