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PMC11064533
Stress with gentamicin depicted similar results, where it significantly inhibited the growth as shown in Fig. S5B.
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PMC11799978
Given that the acidity plays a major role in altering the phenotype of tumor stromal cells and promoting fibroblasts to acquire an activated status, it is reasonable to hypothesize that restoring the pH can directly reprogram CAFs back to its quiescent state, therefore limiting tumor growth indirectly.
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PMC11371747
The substrate affinity of PCFT for the various LV formulations was assessed relative to the antifolate substrate Pemetrexed (PMX) in CHO-C5 cells transfected with human PCFT.
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PMC9688728
Upon reaching ~80% confluence, the cells were detached with trypsin-EDTA solution (PanEco, Moscow, Russia) and subcultured.
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PMC11706491
So far, we have shown that cells expressing the 4 fluorescent markers, behave exactly as their progenitors without the fluorescent proteins.
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PMC11064533
Next, the gene set enrichment analysis (GSEA) function from the clusterProfiler package was used to perform a gene set enrichment analysis for COG functions/categories (31).
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PMC4485648
The encoded proteins include VEGF as a mediator of tumor angiogenesis, GLUT-1 and glycolytic enzymes as mediators of metabolic reprogramming of cancer cells, CA IX as a mediator of acid-base balance in the tumors and many other regulatory molecules.
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PMC9429973
Furthermore, we evaluated the cellular viability in REH, RS4;11, 697 and TOM-1 cell lines after exposure to iron as ferric ammonium citrate (FAC 100 to 400 µM), deferoxamine (DFO 25 µM) and FAC+DFO (100 µM + 25 µM), using MTT assay at 24-48 and 72h.
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PMC11342785
Viral supernatants were collected 3 days after transfection and passed through a 0.45-mm filter to remove cell debris and then incubated with NIH 3T3 cells containing polybrene 8 μg/ml.
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PMC11612794
These results suggest a linkage between the regulatory mechanisms governing the interactions of binding region 1 and 2 of CENP-T with Mis12C.Figure 4The Dsn1 basic motif regulates the chicken CENP-T-Mis12C interaction(A) Overview of the Mis12C auto-inhibited state in the AlphaFold2 predicted structure of chicken Mis12C...
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PMC11747467
Compared to the control group, RC48 with 10 mg/kg and ART with 50 mg/kg slightly reduced tumor size and weight.
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PMC8903741
A Schematic representation of the sandwich ELISA for selecting the positive clones of antibodies.
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PMC11468365
Conversely, the colon cancer cell line ‘SW620’ has the highest predicted synergy score of 45.6 with drugs ‘VINBLASTINE’ and ‘DASATINIB’ but the predicted sensitivity score is low at 11.1.
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PMC11536589
Combination of PKF-118-310 with MRTX1133 obviously suppressed tumor growth compared with treatment with vehicle, PKF-118-310, or MRTX1133 alone as measured by tumor volumes and tumor weights at the endpoint (Fig. 7B).
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PMC8481254
Fig. 5A Overexpression of CDK19 stimulated OGT, O-GlcNAc, and YAP expression, as measured by WB in Bel-7402 and Bel-7404 cells.
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PMC11733919
Hydrodynamic diameters and surface charge were studied by dynamic light scattering (DLS) and ζ-potential measurements using a Malvern Zetasizer Nano instrument.
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PMC11767725
Despite these advances, the clinical translation of combined metabolic and microbiota-targeted therapies faces significant challenges.
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PMC7709199
PNGase F treatment leads to an apparent single population that is approximately 5 kDa smaller (Supplementary Fig. S1).
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PMC11783017
Extracellular ATP levels in K7M2 cells. (
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PMC11388384
Trace reflects mean +/− SEM. (
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PMC9325715
The iron desorption at pH 1.2 was estimated as 57.97 ± 3.48%.
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PMC4816271
Balb-C mice were innocultaed with 1x10 CT26 or CT26-GD2 cell mixed in matrigel.
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PMC9429973
AUROC values were 0.77 and 0.74 in the training and validation datasets.
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PMC9429973
In particular, mutations in the GUK (Guanylate Kinase) domain seem to be involved in modulating the self-inactivating capacity of CARD11.
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PMC10421378
NaOH consumption and pH changes over time were constantly monitored to determine the end of the exponential growth.
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PMC9429973
Interestingly, sdRNA expression varied significantly between different AML patients.
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PMC11612315
b–e Mean normalized calcium influx in HEK293T cells transfected with rat TRPV1.
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PMC9429973
I-RCHOP had greater QALE (7.9 years [SD: 0.04]) and the incremental cost-effectiveness ratio (ICER; cost gained per QALE) was CAN$16,478.84/QALE compared with RCHOP only strategy (QALE: 5.3 years [SD: 0.02]).
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PMC11659734
No increase in the frequency of structural chromosomal aberrations was observed at any tested concentrations of BPE compared to the negative control cultures.
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PMC11612794
The structural model of the human KMN complex suggests that the Dsn1 basic motif binds to the Head1 and Head2 of Mis12C, which forms the closed conformation of the Head domains and masks the Nsl1 acidic surface (auto-inhibited state).
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PMC11787355
In line with this, the relevance of the CD4::CD8::APC (antigen presenting cell) immune triad for solid tumor eradication has been highlighted recently.
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PMC11519567
Scale bars, 200 μm.
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PMC11732628
However, the role of miR-490-3p in osteosarcoma still needs further exploration.
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PMC8348645
In conclusion, among the three plant extracts, W. somnifera leaves extract exhibited the highest carcinogenic cell inhibition via apoptosis when induced to the HepG2 cell line in vitro, while the C. sinensis and V. vinifera extracts showed lesser inhibition activity in DPPH and MTT assay, hence, were not further subjec...
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PMC9429973
However, in our cohort most patients who carried CALR as driver mutation seem to need one or more additional mutations.
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PMC11679033
This method allowed the assessment of DNA damage immediately after exposure to test compounds.
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PMC10421378
As stated by Wang et al. , the live/dead state does not influence the adhesion ability of certain probiotic strains.
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PMC6160470
Figure 1Structures of monoaza-crown ethers (MACs) and diaza-crown ethers (DACs).
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PMC4005030
Phenolic acids are naturally occurring compounds found in plant kingdom with unique structural similarities, presence of carboxylic group as in caffeic acid, gallic acid, p-coumaric acid, vanillic acid, ferulic acid, and protocatechuic acid (PCA) (Figure 1).
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PMC9429973
Further studies are needed to better understand the role of these biomarkers on lymphoma care and to validate our findings.
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PMC11711063
In HME‐hTert cells ZG16B weakened adhesion with fewer cells remaining attached after 5‐min cycles of trypsinization and washing, was detected in a trypsin‐sensitivity assay (Figure 2H).
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PMC9429973
Moreover, the low expression of CXCR4 on PMN-MDSCs could be, on one hand, related to the low expression of this receptor on CD34 cells or suggest a MF-specific recruitment mechanism, other than that observed in solid tumors.
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PMC9429973
The ITP began to recover around 8 days earlier than initial presentation (Figure dashed curves).
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PMC10452486
Similarly, Face-2 molecules cluster on activated normal B and T cells, on cells of B and T lymphoblast lines, and on transformed fibroblasts .
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PMC11317131
We improved PASTE by incorporating twin PE pegRNA (22) and observed that the fused integrase architecture indeed outperformed traditional twin PE with wildtype Bxb1 integrase.
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PMC7759933
In toxicology, it is nowadays recommended to use alternative in vitro models for the implementation of the 3R (reduce, refine, and replace) strategy as well as considering the inaccurate prediction of animal models due to inter-species variability.
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PMC11763126
Fig. 6CBDP1 binds and regulates the ubiquitination of YTHDF2.
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PMC3734024
Fluorochrome-conjugated antibodies and isotype controls were obtained from BD Biosciences (anti-CD19-APC, anti-CD19-PECy7, anti-B220-PECy7, anti-CD93-FITC, anti-CD23-FITC, anti-IgM-PECy7, anti-CD21-PE, anti-CD24-PE, anti-CD5-APC, anti-CD1d-FITC, anti-CD125-PE, anti-FasL-PE, anti-FasL-Biotin) or Biolegend (anti-CD3-APC,...
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PMC11756514
However, it was later shown by Bufler et al. (48) that SP-D did not aggregate any of the 10 strains tested.
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PMC11686380
Dysfunction in inhibitory neurons is likely associated with neurological conditions such as epilepsy, anxiety disorders, schizophrenia, and ASD.
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PMC9398137
Early clinical trials evaluating safety profile of MCL1 inhibitors will be essential for further clinical development of the currently tested agents.
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PMC11696576
c Model for the role cPLA2α in inhibitor-sensitive cancers.
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PMC11267830
e Moreover, RBM39 knockdown significantly inhibited the proliferation of J. gamma1 and Jurkat cells.
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PMC11345828
The aqueous layer was separated and extracted with EtOAc (2×).
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PMC11704135
The study aimed to determine the antibacterial activity of the synthesized pyrimidine derivatives compared to the antibiotic floxacin and the antifungal activity compared to itraconazole, to assess their potential as antimicrobial agents (Table 2 and Fig. 10).Table 2Antimicrobial activity of the synthesized pyrimidine ...
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PMC9429973
Therefore, she received the association ATO-ATRA in second line, obtaining the second complete remission with a chemo-free regimen.
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PMC8469018
Teriflunomide, active metabolite of leflunomide, inhibits the activity of DHODH, an enzyme crucial for de novo synthesis of pyrimidine nucleotides in activated lymphocytes .
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PMC11803918
Whole-body images were captured at different time points after Ce6 systemic injection (n = 3) under a PE IVIS Spectrum.
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PMC11705901
The function significance of these polymorphisms has received little attention in comparison.
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PMC7987994
One day before the exposition, L929 cells (or U-2 OS cells) were trypsinized and resuspended in MEM + 10% FBS to create a suspension with a concentration of 1 × 10 cells per ml.
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PMC10719213
Mutation level in individual donors is shown in Supplementary Fig. S1.
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PMC11719944
At present, the standard treatment for T1D is insulin; however, it is not effective for many people in terms of optimally controlling glucose levels.
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PMC11791203
Field emission scanning electron microscopy (FE-SEM) images of the HT29 cell line after 48 h of treatment with the chloroform extract of H. malabarica.
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PMC11665584
Though similar in the overall progression of wound healing, the oral mucosa is known to heal faster than the skin and with higher fidelity (i.e., absence of or minimal scarring) and regeneration of adnexal structures, such as salivary glands (2).
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PMC9429973
In follicular lymphoma (FL) its role remains controversial and few studies have looked at this topic specifically.
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PMC11394730
In addition, piperine has demonstrated the ability to induce the differentiation of osteoblasts by affecting the expression of osteogenic marker genes through AMPK phosphorylation and inhibiting the Wnt/beta-catenin signaling pathway in breast cancer .
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PMC11612315
Mean normalized 340/380 ratios of sequential CAP-induced calcium increases (mean ± S.E.M.; right).
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PMC11224020
e, Left, representative images of WASp/WASp DCs.
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PMC11359735
The latter renders GPI anchors resistant to the action of PI-specific phospholipase C (PI-PLC) and makes these anchors, accordingly, harder to identify.
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PMC9429973
Many methods used in conventional clinical diagnosis could not fully detect fusion genes.
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PMC11612508
They also provide long-term therapeutic benefits by improving solubility and protecting them from enzymatic and photolytic breakdown.
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PMC9429973
We then evaluated the precision of this signature to predict survival at 6 months, 1 year and 2 years after diagnosis using cross-validated cox models.
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PMC11365427
In conclusion, phenylalanine is essential for the proliferation of MM cells.
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PMC7642379
Common differentially expressed (DE) genes in pairwise comparisons of all HEK293 cells.
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PMC11701801
Data are presented as the mean ± SEM.
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PMC4270159
NRG1 should cause phosphorylation of HER3 in MCF7 cells.
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PMC11489275
However, the dynamic change of peripheral blood lymphocyte count in the disease course of anti-MDA5 + DM patients and its relationship with the prognosis of the patients have not been studied deeply.
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PMC9429973
Univariable analysis showed that ECOG ≥2, leukemic phase, elevated LDH, MIPI score, POD12 and POD24 were associated with inferior OS.
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PMC11767725
Fungal and viral components of the microbiota also play significant roles in skin health and disease.
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PMC11128598
Histograms show the mean of 3 independent experiments.
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PMC10329074
The difference of YBX3 expression in samples with different T stages. (
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PMC10547921
The dimerization of the TLR7–UNC93B1 complex is mediated by both TLR7‒TLR7 and UNC93B1‒UNC93B1 interactions, which occur at the top and bottom regions of the 2:2 complex, respectively.
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PMC8875242
The docking analysis also showed a narrower contact of abacavir with the binding cavity when compared with lopinavir (Figure S2).
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PMC9844987
This demonstrates that the sequence and architecture of a promoter may influence its variability in expression across individuals.
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PMC11449273
The purity of the nuclear fraction was confirmed by immunoblotting with tubulin and lamin antibodies, respectively, which also served as loading controls.
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PMC8526701
PUMA also activates pro-apoptotic members, such as Bak and Bax, which results in caspase activation and mitochondrial dysfunction .
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PMC5673060
HSP90 inhibitors have been deployed as salvage therapy in clinical trials for TKI-resistant lung cancer and GIST with varying results , .
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PMC11470999
The Coomassie Brilliant Blue staining results showed that a specific protein band appeared at around 100 kDa in the PF‐treated sample upon the enzymatic hydrolysis of proteinase K at a dilution ratio of 1:900 (as indicated by the red circular symbol in Figure S2).
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PMC9429973
COTA’s Real World Evidence (RWE) database is comprised of longitudinal, HIPAA-compliant data abstracted from electronic health records (EHR) from over 200 sites of care in US (60% academic, 40% community).
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PMC11621565
Based on the MTS and LDH end-point assay results, several concentrations were chosen to evaluate their effects for 120 h, such as 10 µg/ml, 40 µg/ml, and 80 µg/ml of rhamnolipid (A), 1 µg/ml, 32 µg/ml and 64 µg/ml of LPS (B), 16 µg/ml of curli CsgA (C) and 16 µg/ml of PSMα1 (D).
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PMC11380329
Vitamin D which is produced endogenously in the skin by a photochemical reaction is the precursor of 1,25-dihydroxyvitamin D in the organism, a steroid hormone involved in various vital processes in the body, including pathways that inhibit cancer promotion and progression.
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PMC9096373
When combined with RT, APA could further reduce 66.0% and 24.5% of VEGFR-2 and CD31 expression compared with the DDPs + RT group, respectively.
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PMC8992508
BCRP-overexpressing MDCK II BCRP cell line was used to evaluate the inhibitory effect on BCRP by the Hoechst 33342 or pheophorbide A accumulation assay.
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PMC7987994
Cells were washed by phosphate buffer saline (PBS) and resazurin solution (final concentration 25 µg · ml) in MEM + 10% FBS without phenol red was added.
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PMC11525293
The cell supernatants were collected, and IL-8 levels were quantified by the ELISA assay.
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PMC11098378
However, the mechanism(s) by which PSMC1 and proteasome activity restrict arbovirus replication will require additional studies in the future.
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PMC10024132
These results suggest that when coupled with an appropriate tumor-targeting CD19 gene transfer, the blinatumomab-secreting γ9δ2 T cells could provide excellent solid tumor cell-killing effects.
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PMC9429973
The 5-year overall survival estimate for all patients was 46%, and 5-year PFS was 41%.
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PMC10976516
These results showed that intrinsic high levels of VEGF inside the tumor vasculature could increase OV tropism for endothelial cells and exemplify how vascular-targeted OVs can improve cancer treatment efficacy.
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PMC9512971
Thus, the dose used in this study had a safety margin of 1.4-fold.
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