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BioData-CellLine_annotated

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PMC11474209
Then, cDNA-MNPs and MC-LR aptamer-AuNPs conjugates were utilized as signal and capture probes, respectively.3Photoelectrochemical (PEC)Advantages - They have a high sensitivity and can detect small biological compounds.
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PMC10243817
All the observed peaks higher than those of the random max peaks (P < 0.01) were selected, and the target genes of MEX3B were finally determined by analyzing the location of all the MEX3B binding peaks in the human genome.
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PMC11248911
Autodock tools were utilized to create the required pdbqt files since Vina Autodock requires the receptor and ligands to be in pdbqt format.
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PMC11470999
This mechanism results in non‐saturable kinetics without a hook effect and enhanced bioavailability due to their smaller molecular size.
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PMC11607321
This comprises a total of 1523 cancer cell lines for which at least two datasets were available (Supplementary Data 1).
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PMC11626627
Overexpression of TWIST1 partially increased the expression of N-cadherin and vimentin (Fig. 3A).
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PMC11779993
In order to examine cell division control protein 42 (Cdc42), Ras-related C3 botulinum toxin substrate 1 (Rac1), Ras homolog family member A (RhoA), p38 mitogen-activated protein kinases (p38), extracellular signaling-regulated kinases (ERK), protein kinase B (Akt), steroid receptor coactivator (Src), and focal adhesio...
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PMC7136814
Cells were seeded into 6-well plate at 0.4 × 10 cells per well, 24 hrs prior to treatment with Vincristine (1 and 10 nM) or Doxorubicin (0.1 and 1 μM) for 48 hrs.
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PMC11442172
Conventional cancer cell metabolism studies have predominantly been conducted using two-dimensional (2D) cell cultures.
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PMC11742431
The degradation level was closely related to the treatment time with the concentration of the working proteins.
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PMC7762347
Based on the results of our study, it could be concluded that CYN and CYN/MCLR mixture induced similar time-dependent up-regulation of genes implicated in DNA damage response, confirming the induction of DNA lesions and their subsequent accumulation in HepG2 cells resulting from CYN exposure.
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PMC11732628
We present this article in accordance with the MDAR reporting checklist (available at https://tp.amegroups.com/article/view/10.21037/tp-2024-529/rc).
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PMC10778532
Decreased expression of E-cadherin by immunohistochemistry staining was already described in sunitinib resistant tumors .
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PMC9895440
All recorded images in single colors are shown in in Supplementary Figs. 1, 2.
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PMC9429973
S. Ding, J. Wang, Y. Wang, S. Cui, Z. Li, X. Yin, J. Xu, K. Liu, R. Xu hematology department, Affiliated hospital of shandong university of TCM; The 1st clinical college, ShanDong University of TCM, Jinan, China Background: Defects in mitochondrial dynamics are associated with many human diseases including leukemia.
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PMC11742231
The study assesses the effectiveness of MGATAF compared to various established models as baselines,such as tCNNS and variants of popular graph neural network-based models, including GCN , GIN , GAT , and SuperGAT .
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PMC3888431
In addition to the reference-based approach a non-reference-based pipeline was used to merge the initial Cufflinks, Trinity, and Oases assemblies.
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PMC8633974
d-e) CEMss CD4+ T cell lines were challenged with HIV-1NL4-3-Δtat-Δnef-eGFP at an MOI of 0.1 and assayed at noted time points for RT activity (P value determined by unpaired t-test) (d).
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PMC11482552
HPV testing, with its strong negative predictive value, has allowed the extension of screening intervals from approximately three years with cytology-based primary-screening protocols to five years for those who test negative .
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PMC3675084
The compound BPR0L075 was synthesized as described previously .
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PMC10758402
Briefly, all infectious samples were serially diluted then transferred into monolayer of Vero cells.
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PMC11697703
Spine formation is strongly regulated by activity during differentiation and maturation; however, intrinsic neuron-specific mechanisms may also contribute to the distinct spine developmental dynamic characteristic of each neuron type.
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PMC8345486
Compound 2, unlike compound 23, did not increase the expression of p53 or its phosphorylation or acetylation (Figure 8A,B).
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PMC7841067
A, B) Cell migration and invasion were measured using the Transwell migration and invasion assays, respectively. (
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PMC10698968
The unexpectedly short DT of MF-R 3 can be explained by the cell line originating from a second recurrence, since cell growth characteristics are likely related to the clinical stage and tumour grade of the original biological material.
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PMC10094992
Therefore, continued research focused on identifying new and promising targeted therapies is crucial.
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PMC9429973
The heterogeneity of these disorders often hampers correct clinical diagnosis.
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PMC7153288
1Fig.
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PMC11502443
The lower Emax observed for tirzepatide was broadly consistent with a previous report.
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PMC11763126
Lung metastasis was examined on day 42 using an in vivo imaging system after intraperitoneal luciferin injection.
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PMC10165258
These confinement gradients lead to the formation of a monodisperse emulsion of droplets with a high level of robustness and independently of the physical properties of the fluids.
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PMC10197932
PBMC were separated from Peripheral blood by PBMC 24+ Spin Medium gradient (PluriSelect Life Science, Germany), then cultured in RPMI-1640 supplemented with 20% FBS for one day followed by fresh RPMI-1640 supplemented with 10% FBS.
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PMC9429973
Statistical analysis was performed using the chi-square test.
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PMC11107915
In the majority of the cases (Cases 1–8 and Case 10), ChatGPT provided accurate diagnoses, aligning with the correct answers from the FMGE key.
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PMC11697703
As shown earlier, MAPK8 is reduced in layer II-III miR-193b or -365 electroporated neurons (Figures 2J, S2E, and S2I).
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PMC11462673
To further validate the in vivo anticancer activity of MBZ, we established a T-ALL mouse model using 6 T-CEM cells.
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PMC11247842
b Manhattan plot for somatic cell count .
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PMC9429973
Patients with pleural effusion had higher median Cmin values when compared to those without (2.17 ng/ml vs. 1.18 ng/ml, p value – 0.558).
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PMC11575040
Fig. 2Suppression of melanoma cell growth by LINC00094 knockdown.
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PMC8567602
Another smaller amount of protein, revealed by anti-SMARCB1 WB, appeared in gradient fractions consistent with BAF-family subunit monomers, running at a higher size than the predicted 47 kDa (Fig. 4C).
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PMC3734024
CD19 B cells were cultured as illustrated in (A) and harvested after five days.
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PMC8526701
The mRNA levels were also increased in GIST samples (Fig. 1C).
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PMC10571053
Additionally, both P-gp and ABCG2 have been shown to confer resistance to several structurally different aurora kinase inhibitors.
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PMC11367146
For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
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PMC10213179
∗p ≤ 0.01 by Student’s t test.
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PMC4839679
The coverslips were blocked for 30 mins with PBS containing 1% BSA and then treated with 50 μL of Phalloidin conjugated to Texas Red (1:40; ThermoFisher Scientific, Waltham, MA) for 30 mins at Room Temperature.
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PMC9250505
As shown in Supplementary Fig. 1G, Rucaparib and Talazoparib exhibited greater efficacy in EOC cell lines; however, no significant correlation with the levels of pBADS99 in EOC cells was observed compared to Olaparib treatment after 6-days.
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PMC9019892
Secondary drug‐resistant mutations, including T670I and V654A, are located at the ATP‐binding pocket, while D816E/H/V, D820E/G/Y and N822K mutations are in activation loops.
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PMC7987994
The variation in the composition of an extraction medium can have a pronounced influence on the corrosion rate as well as on the cytotoxicity results.
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PMC6600253
For the induction of senescence in tumor cells by genotoxic stress or the reactivation of growth-suppressive pathways, the reactivation or re-expression of p53, the inactivation of Myc or Bcr-Abl, and the inhibition of Pten are attractive therapeutic approaches and have been shown to potentiate growth inhibition or tum...
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PMC4360730
The inclusion of synonyms for the free text search allows controlled description of the metadata via the official term name but flexibility in the search term that is used via synonyms.
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PMC9429973
PRO measures were evaluated every 3 months and conducted in the following order: FACIT-Fatigue, PGIS, PGIC, SF-12 and EQ-5D-5L.
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PMC11462673
It primarily collaborates with master transcription factors (ERG, ETV6, IRF1) to cooperatively regulate the transcription of downstream target genes.
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PMC11739670
The binding of CD8αβ and CD8αα to antigen‐presenting molecules carrying different ligands was studied by SPR (Figure 1, Table S1, Figure S2–S4).
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PMC11617590
SFN abrogated resistance by interfering with nuclear factor (NF)‐κB binding in highly treatment‐resistant tumor‐initiating cells such as Mia PaCa‐2 cells .
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PMC11476106
For digital analyses of 3D models, a semi-automatic method was developed to detect HG area, clusters, and cell counts in the scanned H&E-stained slides (Supplementary Materials Section S1, Figure S1).
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PMC11040965
After 4 h at 37 °C, specific cytotoxicity activity was measured using a colorimetric lactate dehydrogenase (LDH) assay (CytoTox 96 Non-Radioactive Cytotoxicity Assay; Promega, # G1780).
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PMC11545737
Pyroptotic cell death in macrophages did not affect the viability of gonococci and it was demonstrated that pyroptosis induction requires viable bacteria .
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PMC11092382
These medicinal plants have been used in healthcare for centuries, especially in East Asia.
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PMC11093197
For handling lentivirus, we strictly followed the National Institutes of Health guidelines.
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PMC10443665
Drug transporter is one of the various mechanisms responsible for drug resistance (45).
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PMC9429973
nature of AML therapy and other factors.
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PMC11085211
The two features—small size and degraded DNA—suggested that AUN could stimulate cell death by triggering apoptosis.
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PMC11126803
Further ChIP assays confirmed that ERβ could bind to the promoter of ZEB1 for posttranscriptional regulation (Fig. 5, F and G).
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PMC11761919
Group 3 included microcapsules (0.1 g) with recombinant E. faecalis.
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PMC10135767
The high specificity of homing is accomplished by lymphocyte adherence to the vascular endothelium at target locations .
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PMC11269933
Bootstrap support values are indicated by sizes on nodes of phylogenetic tree.
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PMC11587541
Table 2Represents the clinical characteristic distribution of the cases and controlsPARAMETERS OF SMACASESCONTROLSP- ValueGender (in %)MalesFemales19 (47.5%)21 (52.5%)36 (62%)22 (38%)0.2139Age (in months) (in %)≤ 36 months≥ 36 months33 (82%)07 (18%)18 (30%)40 (70%)0.003Achieved Milestones (in %)Non-SitterSitterWalker29...
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PMC9812014
For example, papaver plants belong to the Papaveraceae family and contain (opium) alkaloids.
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PMC11194678
The addition of an increasing amount of STAU1 to the reaction mixture gradually enhanced the translation of Luciferase mRNA (Fig. 3 E).
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PMC10092581
Aliquots were employed for the determination of protein content by means of the BioRad assay (BioRad).
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PMC11442172
PDEs are generated by directly culturing fresh, non-dissociated tumor tissue slices in vitro, thereby preserving native tissue architecture, TME, cell-cell interactions and metabolic crosstalk of the in vivo situation (79).
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PMC10362265
Fig. 4(a) Panel shows SASA changes over time for the 74th position and the entire epitope holding this position of hIL18. (
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PMC10932641
GAPDH, glyceraldehyde 3-phosphate dehydrogenase; NC, negative control; lncRNA, long noncoding RNA; SI, silent; OE, overexpressive.
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PMC7553912
In humans, CaOx kidney stones mainly form as overgrowths on sub-epithelial plaques of calcium phosphate in the renal papillae, known as Randall’s plaque.
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PMC9429973
Methods: For the current study we implemented a novel hierarchy of fifteen immunophenotypically defined differentiation stages, which refined the granulocytic and monocytic differentiation hierarchies at a hitherto unprecedented resolution.
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PMC11750696
This response is designed to rebuild ER homeostasis by upregulating the expression of chaperone proteins, enhancing protein folding capacity, and promoting the degradation of unfolded or misfolded proteins (30).
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PMC10317042
EWSR1::ATF1 knockdown significantly inhibited the growth of MP-CCS-SY and SU-CCS1 cells (Supplementary Fig. S2E).
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PMC11767582
Some common drawbacks of the combretastatin family of compounds are their poor water solubility and their tendency to isomerize to the inactive trans stilbenes.
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PMC11683240
Cells were left untreated as further control.
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PMC8540692
Thus, these data confirm that even though curcumin is considered a natural phenolic antioxidant, it can act pro-oxidatively in cancer cells, inducing desirable anticancer effects.
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PMC9080589
The specific primers for PCDH8 were forward, 5′-GCCCAACATGTTCGACGTGC-3′; and reverse, 5′-GGAGTGTCCTTTCCACACCG-3′; and for β-actin were forward, 5′-AAATCGTGCGTGACATCAAAGA-3′ and reverse, 5′-GGCCATCTCCTGCTCGAA-3′. The relative quantification of gene expression level was calculated using the 2 method.
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PMC11743414
These method were also used to confirm the expression levels of the FHL1 gene in the HL60 cell line compared to neutrophils.. Cell Counting Kit-8 and flow cytometry were used to detect the effect of high or low expression of FHL1 on cell viability and apoptosis under the influence of cytarabine and daunorubicin.
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PMC11632064
Gene expression levels were calculated using the ΔΔCt method, in which RNA levels were normalized against TBP or UBE2D2.
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PMC10831439
We studied whether checkpoint inhibition would have a beneficial effect on their cytotoxic functionality.
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PMC9429973
Image: Summary/Conclusion: Depending on the research context, intervention and the desired outcomes, one should carefully choose the required device.
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PMC11407042
Refer to problem 3 and problem 4 for the solution of abnormal absorbance.
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PMC11087055
White asterisks, the polonaise movements at the induced axis which are opposite direction to the authentic midline axis.
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PMC9918897
The results obtained on tumor mass may be attributed to several factors.
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PMC9429973
Mutational signatures were represented by the COSMIC SBS1, SBS7, and SBS15, characterized by aging, ultraviolet (UV) exposure, and defective DNA mismatch repair and microsatellite instability, respectively, suggesting their role in the mutational process of MF oncogenesis.
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PMC11461874
Quantified intensities of DBP that is normalized by that of GFP are plotted on the bottom as dots for individual experiments and as lines for means with SEM (n = 4).
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PMC11574029
NS not significant.
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PMC8956657
IMPα2 bound to NF-κB p50 was crystallized in 700 mM sodium citrate, 10 mM DTT, 100 mM sodium HEPES pH 7.0, with rod-shaped crystals appearing in 2–3 days.
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PMC11342785
Scale bar represents 10 μm. (
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PMC11560255
Ethanol 96%, Dulbecco’s modified eagle medium (Gibco, USA), 2% penicillin-streptomycin (Gibco, USA), amphotericin B (Sigma-Aldrich, USA), HEPES (Sigma-Aldrich, USA), 10% fetal bovine serum (Rocky Mountain Biologicals, Inc., USA), 1 × phosphate buffer saline (PBS) (Sigma-Aldrich, USA), dimethyl sulfoxide (SigmaAldrich, ...
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PMC11661040
DAB Color Development Kit (Servicebio Technology, China) was used for color development.
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PMC9622879
In the no-CEMS scenario, the selling energy is greater than that of two cases in these times slots.
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PMC3813807
Previously, Cho et al(17) analyzed the expression of the miRNA-371–373 cluster in four human gastric cancer cell lines, SNU-1, SNU-638, SNU-719 and AGS, and one normal human gastric cell line, Hs677.sT, and identified that miR-372 expression was markedly elevated in the AGS cells.
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PMC9429973
DOT was defined as time from initiation to discontinuation of each LOT.
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PMC9895440
i Geometric mean CD25 upregulation relative to unstimulated cells for Teff co-cultured with T2 wt or T2 CD80 CD86 KO (T2 KO) cells.
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