PMCID string | Sentences string | ner list |
|---|---|---|
PMC10761571 | Studying the effect of Fe3O4@Glu-Gingerol on the expression of the CASP8, BAX, and BCL2 genes showed that treatment of the Fe3O4@Glu-Gingerol significantly up-regulated the BAX and CASP8 genes, and attenuated the BCL2 gene. | [
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PMC9370419 | Docking model results revealed that estradiol benzoate binds to HBx at TRP87 and TRP107. | [
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PMC9429973 | Responding pts received vincristine and prednisone maintenance with VEN daily on D1-14 of each 28-day cycle for up to 2 yrs. | [
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PMC10969097 | The reviewers, JF, SR and JV, started searching the Web of Science, Scopus and Pubmed databases on 6 September 2023. | [
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PMC10671321 | Primary antibodies were diluted in the blocking buffer, and cells were incubated with these antibodies overnight at 4 °C (see Table S1 in Supplementary Material). | [
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PMC11705630 | The mortality of RCC varies mostly depending on cancer stages. | [
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PMC9429973 | However, the role of RDW at diagnosis in patients with JMML is still unclear. | [
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PMC6600592 | Cyclohexyl 4-(4-chlorophenyl)-4-oxobutanoate (3D). | [
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PMC9429973 | Following this, the peroral cyclophosphamide and prednisolone combination therapy was initiated and resulted in complete remission inside of 4 months from the treatment initiation. | [
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PMC11397654 | Akhmedov, Stoikov, and their co-workers envisaged the combination of the antiangiogenic drugs with diagnostic agents in order to obtain theranostic compounds. | [
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PMC11519077 | To reach a final volume of 20 μL, a combination consisting of 10 μL SYBR green mix, 1 μL cDNA (250 ng), 1 μL PCR forward primers, and 1 μL PCR reverse primers in 5 pmol/μL, and Millipore water was added. | [
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PMC9261184 | The containment system is a membrane type “Mark III Flex+”, which has a rated maximum boil-off generation of 0.07% of the cargo per day. | [
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PMC4369959 | Ginger may upregulate or downregulate the gene expressions, depending on the target and cellular context. | [
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PMC6461034 | Asterisks represent the level of significance (**P < 0.01; ****P < 0.0001). | [
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PMC8469018 | The samples were incubated for 15 min at 37 °C, centrifuged at 400× g for 5 min, and were resuspended in 100 μL of Annexin V binding buffer supplemented with 10 μg/mL PI (prepared by add 2 μL Solution 16 to 100 μL binding buffer). | [
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PMC11252553 | Background values (non-irradiated & untreated samples) are subtracted from each point shown on the graph. | [
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PMC9429973 | Patients received BOR, LEN + DEX (VRd), or CFZ, LEN + DEX (KRd) for 3 cycles. | [
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PMC9429973 | Combined STP938 and ATR inhibition showed anti-proliferative activity in all cell lines, including those resistant to single agent STP938. | [
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PMC11224020 | cPLA2 is in gray, and the nuclei are in red; scale bar, 5 µm. | [
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PMC7351993 | The IA node receives the UDP packets from the DA nodes and makes a sort/unsort decision based on the results of the SRS image reconstruction and analysis. | [
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PMC9429973 | For CAR T cell expansion,the peak time in vivo was on median 14(range,11-29) days after CAR-T cell infusion. | [
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PMC9429973 | EO2463 will be administered subcutaneous 4 times at 2-week intervals, followed by continued booster administrations every 4 weeks for 9 (Cohorts 2 and 3) or 12 (Cohorts 1 and 4) months. | [
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PMC3730428 | In the absence of cIAP1/2, RIPK1 is not polyubiquitinated and forms a second complex (complex IIb), which recruits Fas-associated via death domain (FADD), caspase 8 and FLIP. | [
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PMC11453018 | Selection was achieved by puromycin (2 µg/ml), and confirmation was conducted by FACS analysis of GFP-positive cells. | [
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PMC9429973 | According to Western blot results, the phosphorylation of JAK/STAT signaling pathway associated proteins JAK2, STAT3 and STAT5 were significantly suppressed by TQ05105. | [
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PMC11283030 | VC: nonsense RNAi, Si: ACLY silencing. | [
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PMC11638288 | Immune abnormalities are one of the contributing factors to infertility. | [
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PMC10777969 | To verify this hypothesis, A2780 cells were incubated with FCP23 or FCP26 in the presence and absence of two different free radical scavengers: tocopherol and PBN. | [
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PMC11525028 | We next explored the role of ATF4 and ASNS in osteosarcoma. | [
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PMC10957991 | 184A1 Mammary epithelial cells were treated with either ctrl siRNAs or TRPV4 targeting siRNAs, cultured on 0.2 kPa compliant matrices or on plastic. | [
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PMC11422497 | shRNA: short hairpin RNA. | [
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PMC11116779 | Plastic is one of the most convenient existing materials and is widely used worldwide. | [
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PMC11095939 | In addition, the increased liver index caused by the loss of Mecp2 was significantly compromised by Mecp2 restoration (Figure 2L). | [
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PMC11629143 | Relative transcript levels were normalized to 5.8S rRNA using the 2 method. | [
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PMC11638288 | Furthermore, therapeutic blockade of NKp46 can alleviate liver inflammation and reduce NK cell activity prior to IFN therapy, thereby enhancing IFN-induced NK cell activation and rapid viral control . | [
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PMC8740518 | The residues of each sample were then added with 20 µL of 20 mg/mL methoxyamine hydrochloride (AR grade; TCI, OR, USA) in pyridine (HPLC grade; Adamas Pharmaceuticals, CA, USA). | [
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PMC7348793 | This PCR product was subjected to an initial round of sequencing with primers agmF1-agmF32 and agmR_1-agmR_29 (Supplementary Table S2). | [
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PMC9516401 | Given these, it is reasonable to assume that all the mentioned extracts in the present study could exert anti-proliferative effects by interacting with the critical molecules in regulating cell growth and glucose metabolism. | [
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PMC11711663 | This study aims to identify imaging biomarkers associated with PFS in these patients. | [
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PMC11507371 | This may involve increased NF-κB translocation, enabling upregulation of pro-apoptotic proteins. | [
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PMC11519583 | control: 960 myofibers from three animals (e) and 1061 myofibers from four animals (f), Ror2 cKO: 2779 myofibers from five animals (e) and 1344 myofibers from four animals (f)). | [
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PMC11519077 | Among various sources of MSCs, adipose tissue and bone marrow are the two adult tissues from which MSCs are most frequently obtained [24–31]. | [
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PMC9847912 | For these assays, the MAGIC-5A cells were seeded one day prior to infection at 5 × 10 cells per well in 200 μl per well of culture medium. | [
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PMC11721587 | Whether the formation of intracellular condensates can be regulated by extracellular signals such as morphogens has been underexplored. | [
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PMC8623816 | For hyphal tipping, we cultured RsRV5-infection strain D122 on WA, using a surgical knife to excise mycelial plugs containing the tip of a single hyphal under the microscope, and each small piece was cultured on WA. | [
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"O",
"O",
... |
PMC11343332 | The progression of cancer arrests the apoptotic process. | [
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PMC11718109 | Fig. 7VGLUT1, VGLUT2 and VGAT show preferential recruitment to synaptophysin-synapsin over VMAT2-synapsin vesicle clusters. | [
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"tags": [
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"O",
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PMC11585587 | Chemical structure diagram of RA (A). | [
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PMC11629192 | These allergic reactions and liver enzyme increase were improved after symptomatic treatment and did not occur in the subsequent dose of OFA, whether the dose of OFA and the interval between each must be adjusted in pediatric patients requiring further research. | [
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... |
PMC8973085 | Additionally, the pyridine moiety is incorporated in many drugs, including anticancer, antiviral, antimicrobial, anti-inflammatory, antihypertensive, analgesic, antimalarial and antidiabetic antioxidants, psychopharmacological antagonists, and insecticidal and antiamoebic agents. | [
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PMC9429973 | Methods: VLA-4 activation/affinity was determined by flow cytometry (FC) using the conformation-sensitive anti-CD29 mAb HUTS21 and/or by “real-time” (FC) measuring the binding of the VLA-4 ligand LDV-FITC as reported (Tissino et al, J Exp Med, 2018) in: i) 1,984 consecutive CLL all with IGHV gene mutations/BCR features... | [
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... |
PMC10582049 | For instance, CAFs can produce cytokines that can modulate anti-cancer immune responses. | [
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PMC11742290 | One intestinal study introduced lacZ into LGR5 + CBC cells . | [
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PMC9509578 | Chen et al. reported co-delivery of doxorubicin and Bcl-2 targeting siRNA via mesoporous silica nanoparticles resulting in enhanced cytotoxicity in human A2780/AD ovarian cancer cells. | [
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"O",
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PMC11718109 | Collectively, these results indicate that iPSC-derived DA neurons exhibit synaptic properties typical of a neuron from day 50 onwards in culture. | [
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PMC8735881 | In order to exclude the potential impacts caused by a lentiviral vector, the expression cassette of GPI-10E8 was also subcloned into the plasmid expression vector pcDNA3.1. | [
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PMC11792090 | After washing, the cells were resuspended in PBS and analyzed by flow cytometry. | [
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PMC6901583 | Lamin A/C and β-actin, which are expressed in nucleus and cytoplasm, respectively, were used as controls for loading and fractionation. | [
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"tokens": [
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PMC5716223 | b, c Quantitative analysis of αB-Cry and Hsp27 expression during differentiation process (2, 5 and 9 days) of myogenic cells supplemented with or without NGF (αB-Cry: NGF 1.3 ± 0.08 vs Ctrl 2.0 ± 0.11, p < 0.05; Hsp27: NGF 1.0 ± 0.03 vs Ctrl 0.53 ± 0.04, p < 0.05). | [
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PMC2118063 | Staining for IRF8 at an original magnification of 10. ( | [
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PMC10956161 | With regard to the impact of the PRDX6 gene on survival in lung adenocarcinoma, the survival curve showed that patients with a high level of PRDX6 gene expression had a significantly shorter survival duration compared with those with low PRDX6 expression levels (P < 0.05) (Figure 5a). | [
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PMC11767817 | All subsequent analysis steps were performed according to the manufacturer’s protocol. | [
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PMC9812014 | Cinchona plants belong to the Rubiaceae family, famous for cinchona alkaloids. | [
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PMC9611901 | These results are consistent with our own observations. | [
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PMC9429973 | We assessed hematological profile, serum ferritin, urinary albumin–creatinine ratio (UACR), serum cystatin C, echocardiography and carotid intima media thickness (CIMT). | [
{
"tags": [
"O",
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PMC11066331 | For DT 99.0 % accuracy was obtained (Cl = 94.7–100.0 %). | [
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PMC9429973 | TfR1 internalizes iron-bound transferrin, a process fundamental for erythropoiesis. | [
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PMC11290772 | Tissues showing positive ROBO1 expression were used to establish primary tumor cells and tumor organoids. | [
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"O",
"O",
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PMC10940855 | We have shown that silencing of EFNB2 expression suppresses multiple myeloma growth in vitro and in vivo, but this approach does not discriminate whether EFNB2 forward or reverse signaling is the essential mechanism of action. | [
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"tags": [
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PMC11765243 | The percentage and characteristics of the small population of immature CD3CD8 SP cells (iSP8) that are precursors of CD4CD8 DP thymocytes were also unaltered (Figure S2). | [
{
"tags": [
"O",
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... |
PMC8270637 | Activated H9 cells were seeded in six-well plates at a density of 2×10 cells/mL. Subsequently, TGF-β1 (5, 10, and 20 ng/mL) was added, and the cells were incubated for 48 h. The same medium without TGF-β1 was added to the control group. | [
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PMC10047551 | To explore the impact of direct recruitment of enzymatic activities involved in methylation and demethylation specifically in regard to the PD-L1 gene, we examined a series of fusions with enzymatically dead Sa and Sp Cas9 (dSaCas9 and dSpCas9, respectively). | [
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"tags": [
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PMC9429973 | While most events reported in this cohort were related to catheter devices, spontaneous thrombosis was associated with a higher baseline monocyte count. | [
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PMC11486946 | Two squares were set such that one square was placed in the band and another square was far away from the band, and the difference in the average intensities of these regions was defined as the band intensity. | [
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... |
PMC11644761 | The human neuroblastoma cell line SK-N-BE was cultured, under standard conditions of 37 °C and 5% CO2, in RPMI 1640 which was supplemented with 10% fetal bovine serum (FBS) and 1% Penicillin/Streptomycin (100 U/mL; 100 μg/mL). | [
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PMC11342785 | For example, while TPPP was able to potently bundle MTs within the cell, the interphase MT network derived from centriolar MTOCs dominated the overall structure and spatial distribution of the emergent structure towards the cell center (63, 64, 65). | [
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PMC11519583 | Wnt11-Ror2 signaling is involved in cell migration and actin remodeling . | [
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PMC11297139 | c Representative confocal images of ARID1A + WT and ARID1A + ΔDD A673 cell lines immunostained with anti-FLI1 and anti-ARID1A antibodies. | [
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... |
PMC10595704 | PS-NP reduced cell vitality after 72 h of treatment at all the concentrations used. | [
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PMC9429973 | Results: Twenty-one adult patients with diagnosis of NLPHL (3 of which presented transformation areas to diffuse large B-cell lymphoma (t-DLBCL) in the biopsy), were identified. | [
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"O",
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... |
PMC11476837 | SOD2 catalyzes the dismutation of the superoxide radical and HMOX2 is a sensor of oxidative stress. | [
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PMC11742431 | Also, the secondary antibody used was goat anti‐mouse IgG(H+L) (Alexa Fluor 488; 1:200, Abcam). | [
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PMC9429973 | Finally, longitudinal follow-up and Kaplan-Meier analyses confirm that Pharmacoscopy-measured drug responses are significantly predictive of the clinical response of patients (Figure 1). | [
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"O",
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PMC10778532 | It is also admitted that VHL loss of function due to VHL mutations results in HIF accumulation, leading to a pseudo-hypoxic state despite normal oxygen conditions. | [
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... |
PMC11468365 | These settings are fixed for all the related works being compared to ensure a fair comparison. | [
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PMC9429973 | Image: Summary/Conclusion: PI-exposed, lenalidomide-refractory patients with 1-3 PL were treated with various regimens. | [
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... |
PMC11740907 | During the following days, the group that received Cisplatin treatment had a complete survival rate. | [
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... |
PMC11704834 | To investigate the role of TLE1 in acquired gefitinib resistance of A549 cells, it was first examined if TLE1 expression is altered between A549 and A549 GR cells. | [
{
"tags": [
"O",
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"... |
PMC11782508 | The gene encoding azurin was deposited in the GenBank database under accession number PP848219. | [
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"t... |
PMC11332076 | Overexpressed proteins were detected with anti-myc atntibody. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
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"detected",
"with",
"anti-myc",
"atntibody",
"."
]
}
] |
PMC11568601 | Persistent ER stress facilitates cancer cell survival, while promoting ER stress to initiate apoptotic pathways may be an effective antitumor strategy . | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Persistent",
... |
PMC9024365 | As the SD4-induced clustering of AMPARs likely occurs after endocytosis in heterologous cells, these intracellular clusters of AMPARs co-localized with SD4 are capable of being deployed to synapses upon chemical-LTP in hippocampal neurons. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"O",
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"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC9841531 | Screening of compounds 17–32 against the ABC transporters ABCB1 (A), ABCC1 (B), and ABCG2 (C) applying calcein AM (ABCB1, A), daunorubicin (ABCC1, B), and pheophorbide A (ABCG2, C) assays using ABCB1-expressing A2780/ADR (A), ABCC1-expressing H69AR (B), and ABCG2-expressing MDCK II BCRP (C) cells, respectively. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC10748106 | The anion forms of geniposidic acid and 10-O-(E)-p-coumaroylgeniposidic acid were considered since these charged forms exist predominantly at physiologic pH (7.4). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
... |
PMC7039683 | Cas9 protein and a sgRNA targeting H11 were co-injected into the pronucleus of FVB single cell stage mouse embryos (E0.5) together with the reporter vector (Kvon et al., 2020). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC11531735 | ER121 treatment focusing on experimental brain metastasis in TNBC, HER2+ model, was quantified by total flux employing the In Vivo Imaging System (IVIS). | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC11612315 | Collectively, these data reveal that exendin 20–29 acts as a key sequence in inducing analgesia in CAP-elicited nociceptive behaviors in mice without causing hyperthermia, and this analgesic effect is mediated by exendin 20–29 directly inhibiting CAP-induced TRPV1 activation but not proton-induced TRPV1 activation. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
PMC11721277 | Among the coligands used in HYNIC chemistry, it is EDDA and tricine that represent the best candidates for optimal in vivo biodistribution . | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"Among",... |
PMC11612508 | The magnetic field also enhanced the rate of drug release. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"
],
"tokens": [
"The",
"magnetic",
"field",
"also",
"enhanced",
"the",
"rate",
"of",
"drug",
"release",
"."... |
PMC9429973 | Image: Summary/Conclusion: In our patients, the addition of GO did not impair HSC mobilization and harvesting that was reached in about 71% of cases, similarly to the AML-10 trial of the EORTC and GIMEMA Leukemia Groups where 70% of patients were successfully harvested. | [
{
"tags": [
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... |
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