Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC11023271
We consider our finding a breakthrough in understanding RIPK4 biology.
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PMC9429973
Patients who achieve stable disease/progressive disease (SD/PD) will exit the study.
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PMC3681794
NSC134754 reduced HIF-1α protein levels in U2OS cells in hypoxia, and reduced levels of CA IX (Figure 6A).
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PMC11089031
All samples were obtained from patients with primary ccRCC aged 32 to 84 years.
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PMC9352806
As shown in Fig. 5A, OA caused much higher fat deposition in HepG2 cells compared the control, while BMS significantly decreased the overall fat, which further confirmed the fat-lowering effect of BMS.
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PMC10329074
After culture for 2 weeks, the cells were fixed with 4% paraformaldehyde for 30 min at room temperature.
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PMC11697703
Bottom panel, schematic summary of expression.(B) ATAC-seq in CSMN vs. CPN.
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PMC6461034
For the top 20 kinases (by INKA score), a ranked bar graph and a network of all inferred kinase–substrate connections are visualized as well (Fig 1B).
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PMC9429973
Blood work shows mild lymphocytosis (6800/mm) with no serious cytopenias.
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PMC9545714
Lycopene has been shown to protect against UV damage to cultured human dermal fibroblasts. , ,
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PMC9325715
The study also revealed that during the synthesis some amount of protein can undergo oxidation and oligomerization.
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PMC11285179
Both in vivo and in vitro experiments collectively illustrate that CCL28 derived from tumor cells is pivotal in advancing vascular normalization by mobilizing and reprogramming pericytes.
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PMC10719213
First, the indel qualities were set by command lofreq indelqual—dindel, then variants were called including indels with minimum base call quality 30 by command lofreq call-parallel --pp-threads 20 -N -B -q 30 -Q 30—call-indels—no-default-filter.
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PMC11806613
MDA-MB-231 TNBC cells were treated with OST-01 in a dose-dependent manner for 24 h. Cell lysates were immunoblotted with the indicated selenoprotein antibodies.
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PMC9429973
Pts discontinued dasatinib and were monitored for up to 5 y. All pts provided written informed consent.
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PMC11551844
The enhanced activity of AuNPs-JC2 compared to JC-2 could be due to the more efficient uptake of the nanoparticles by the cancer cells.
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PMC10955424
Non-cellular constituents, such as extracellular matrix (ECM) components, extracellular vesicles, exosomes, cytokines, growth factors, metabolites, and lipid synthesis mediators have been identified in ascites .
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PMC10523483
Key enzymes (blue) involved in GSH biosynthesis and salvage pathways. (
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PMC11036064
It has been found that RAF1 is significantly upregulated in primary GBM compared with normal brain tissues (Figure 2D(Fig.
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PMC9429973
The impact of COVID-19 on medical care was particularly evident in pts treated with hydroxyurea compared to untreated pts (adults: 91% and 79%; pediatric: 84% and 74%).
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PMC9429973
1.1% (n=1).
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PMC10852540
In the comparison of the two groups, depending on the homogeneity of the data, the dependent sample T test or the Mann-Whitney U test were used.
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PMC11300639
Both TKIs and mTOR inhibitors are first-line or second-line drugs for the clinical treatment of ccRCC .
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PMC11787355
Whether CD4 T cells engineered with CD8-restricted TCR can hijack tumor cells to form such a triad to restore and improve CD8 T cell functions will require further experimental investigations.
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PMC11300639
f A model depicting the domain of RNF26.
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PMC10213179
The EA-3 aptamer KD for recombinant EphA2 was not reported.
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PMC11721064
Excessive sclera, conjunctiva, iris, trabecular meshwork, and endothelium were meticulously removed.
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PMC11679892
At the end of the incubation, washing was performed 5 times for all wells with wash solution.
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PMC11777207
All clinically available antibodies either covered or sterically limited the necessary residues for PD-L1:CD80 extracellular interactions, the consequence of which was reduced DC migration.
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PMC11676169
Further, BCAT1-depleted cells showed altered protein acetylation levels, which correlated with an increased sensitivity to DNA-damaging agents such as etoposide.
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PMC9429973
L. Ran, Z. Yang, T. Yang, Y. Nan, Y. Xiang, Y. Liu Department of Hematology-Oncology, Chongqing University Cancer Hospital, Chongqing, China Background: The clinical characteristics, laboratory examination and prognostic characteristics of patients with hemophagocytes detected in bone marrow smears were analyzed retros...
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PMC11472569
Recent studies have pinpointed specific miRNAs within EVs that contribute to MDR dissemination.
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PMC11075223
However, C. dahurica showed the toxic effects on the liver by co-culturing the rhizomes (IC50 = 1.417 mg/mL) and fibrous roots (IC50 = 1.26 mg/mL) of it with human hepatocytes L-02, respectively.
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PMC11658074
Media from NIH3T3 cells was harvested after 24 h of culture in serum-free DMEM when the cells reached 60–70% confluence.
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PMC10956161
ROC, receiver operating characteristic.
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PMC8193813
Comparison of the CEM data to the UAS–Kolibri data from field measurements at two locations showed agreement of NOx emission factors within 5.6% and 3.5% for time-weighted and carbon-collection-weighted measurements, respectively.
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PMC11803149
RNA concentration was measured on a Qubit Flex Fluorometer using an RNA HS assay kit (Thermo Fisher).
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PMC11594588
One of the methods to measure the level of intracellular oxygen is the method that allows for the analysis of the concentration of molecular oxygen in a single layer of cells and their transient changes in metabolic activity in real time (oxygen consumption assay) and T-Tas .
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PMC8916024
This study found that Silanimonas may be used as an open food for juvenile snails in culture.
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PMC11525293
In addition, it has been observed that the SARS-CoV-2 virus induced lower mortality in Len-treated multiple myeloma patients compared to Len-naïve counterparts , supporting that Thal and its analogues might be useful in the management of COVID-19 patients.
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PMC11387401
Gene ontology terms enriched for HIV-1 proteins Gag, Nucleocapsid, Rev, and Integrase are all related to the translation machinery of the host cell, including “cytoplasmic translation” (GO:0002181) and “structural constituent of the ribosome” (GO:0003735).
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PMC11126803
Subsequent in vivo experiments also confirmed that the increase of LncRNA-SERB can promote the expression of ERβ and lead to tumor invasion and distant metastasis.
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PMC11412721
Importantly, survival curves indicated that the Myc-induced lethality was delayed in Trp53 Eμ-Myc males compared to Trp53 Eμ-Myc males, Trp53 Eμ-Myc females, and Trp53 Eμ-Myc females (Figure 2—figure supplement 1C).
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PMC11354225
On the other hand, a wound healing analysis was carried out with 10 µM and 40 µM EGCG.
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PMC9065483
From our findings, we elucidate three molecular events through which vanadate sensitizes cells to oncolytic virotherapy via EGFR activation: 1) dephosphorylation of STAT2, 2) induction of STAT1 nuclear accumulation, and 3) degradation of IκB-ɑ to increase nuclear NF-κB signaling (see graphical abstract).
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PMC10631132
SOX17, an endodermal marker, was consistently expressed centrally within cell-forming complexes differentiated according to the MB protocol in both iPSC lines (Fig. 3F and L).
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PMC11577421
They offer nonimmunogenic and nontoxic characteristics, easy surface conjugation, versatile drug carrier capabilities, and enhanced tumor accumulation through binding to endothelial (gp60) and tumor-associated receptors (e.g., SPARC).
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PMC11412721
Figure 4—figure supplement 4.The knockout of ACKR4 in Burkitt lymphoma Raji cells does not impact their proliferation.
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PMC11547917
The results were multiplied by 100 to calculate the inhibition percent of the viable cells.
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PMC10840195
The migration (C) and invasion (D) abilities of cells were determined by Transwell assays.
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PMC10887351
The mirabegron efficacy was clearly reduced by the β3-ARs antagonist L748,334, but not by the β1 and β2-ARs antagonists, evidencing that, in prostate smooth muscle, mirabegron acted through β3-AR activity.
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PMC11756514
Others have reported the interaction between langerin and S. aureus (22).
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PMC11787355
All patients have provided written signed informed consent in accordance to the WMA Declaration of Helsinki principles.
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PMC11718031
For the top-performing media, including CD-FortiCHO, IS CHO-CD G17.4, and IS CHO-CD G17.7, the osmolality steadily decreased from day 0 to day 8, which matched well with the higher VCC profiles.
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PMC11519788
Notably, reduced SPOP levels in UBC patients were associated with poor clinical outcomes (Figure 1I).
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PMC11748363
Elemental analysis was done on a Vario MICRO cube Elemental CHNS Analyzer (Elementar Analysensysteme, Hanau, Germany) with values given as a percentage.
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PMC11746948
2-BP inhibits a variety of proteins and enzymes involved in lipid metabolism.
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PMC11761919
Therefore, it is crucial to use pH-sensitive materials to encapsulate LAB to prevent degradation.
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PMC11576293
As indicated in Table 1, various compounds selectively suppressed the growth of various cancer cells, with percentage inhibition values more than or equal to 40.
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PMC10507284
Statistical tests: two‐way ANOVA. (
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PMC9370419
The SBHX21 cells were cultured in 96-well Flat Clear Bottom White Polystyrene Microplates (Corning) at 1 × 104 cells per well in DMEM containing Dox (1 µg/mL) for two days.
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PMC11297139
The representative images supported by the relevant statistics have been chosen upon three independent preparations with similar outcomes.
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PMC11295144
However, when α4β3δ-GABAAR-HEK293 cells or control HEK293 cells were transiently transfected with GFP and cherry-tagged NL2 cDNAs and co-cultured with the medium spiny neurons (Figure 2C), we detected a significant increase in contacts induced by NL2 in the presence of α4β3δ-GABAARs (median = 1.81%; IQR = 1.25 - 3.02%;...
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PMC11720107
Briefly, 10 g of lyophilised garlic powder was mixed with 100 mL of PBS and blended in an ice bath.
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PMC9429973
Concerning the aetiology, 51.6% was neoplastic (24.5% [n=12] with ≥5 HLH-2004 criteria), 13.7% infectious, 28.4% autoimmune and in 28,4% the trigger was not identified.
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PMC10956161
The ‘Pan-cancer view’ module was used to display the expression of PRDX6 in a range of cancers (Pan-Cancer).
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PMC11756937
For feeder-grown iPSCs, 90% ESC-qualified FBS was used with 10% DMSO.
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PMC11335267
Nonetheless, given the complexity of the hypothalamic neuronal circuits involving activation and blockade of αMSH receptors located both at pre- and post-synaptic levels, the demonstration of a primary involvement of MC3R in the phenotype of Alx3-deficient animals awaits further investigations, and the involvement of o...
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PMC11796104
As shown in Fig. 1C, nearly 66% host genes corresponding to the dysregulated circRNAs can produce at least 2 circRNAs.
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PMC11543885
B and C) Streptavidin blotting of whole cell lysates (B) and Immunoblotting of the streptavidin beads-pulled down samples (C) from HEK293 cells stably expressing flag-NLRP3-APEX2 under various conditions as indicated.
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PMC9220170
The construction of lentiviral vectors and the production of lentiviral particles were carried out at Evrogen, Moscow.
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PMC7759933
The viability of cells in spheroids was determined by the Live/Dead staining using confocal microscopy, while the proliferation of cells (KI67 marker) in spheroids of different age and cell cycle analysis was assessed with flow cytometry.
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PMC11768927
Despite its success in preclinical animal studies and early human phase I trials, resistance to VSV in certain cancer subpopulations presents a significant challenge to its therapeutic potential .
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PMC8922418
When the first single-stranded RNA (ssRNA) is broken, Cas13a becomes highly sensitive and enzymatically "active", and performs nonspecific cleavage of other RNAs (collateral cleavage) (East-Seletsky et al., 2017; L Liu et al., 2017).
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PMC4485786
Four mice of the NHS-IL12/FcIL-7 and the NHS-IL12/IL-2MAB602 cohort were kept alive and treated at least until day 95 after tumor inoculation. (
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PMC4839679
GO analysis established that upregulated genes enriched biological processes such as cell adhesion (GO:0007155), apoptotic process (GO:0043065), negative regulation of cell proliferation (GO:0008285), carbohydrate metabolic process (GO:0005975) and response to hypoxia (GO:0001666) among others (Fig 3B and S2 Table) and...
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PMC11634794
However, the expression of LAMP1 and its underlying molecular mechanism with ccRCC remain elusive.
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PMC6617630
These results suggest that despite the robust anti-proliferative effects of BETi in DHL/THL cell lines, BETi had only a modest effect on cell viability in DHL and THL DLBCL cells.
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PMC9429973
The most common AEs (reported by ≥ 10% of patients, excluding ADEs related to device product issues) during SC treatment were headache (14.1%, all grade ≤ 2), COVID-19 (14.1%, one death) and pyrexia (10.9%); injection site reaction (4.7%) was the most common non-device related ADE.
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PMC11791478
Animals in the 5 mg/kg group also received a second dose on Day 18, once the average tumor size in the group reached 400 mm.
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PMC11695546
For 48 h, dishes were kept at 36°C.
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PMC10823017
After three hours of incubation, we measured the absorbance at 480 nm on the plate while the reference background wavelength was set at 630 nm.
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PMC7612475
To functionally validate the SF3B1 isogenic model, we performed RNA-seq on total RNA extracted from the K562 SF3B1 and SF3B1 cell lines, or RNA derived from nuclear and cytoplasmic fractions.
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PMC11413393
Finally, we note that type I PRMT inhibition resulted in varying levels of growth inhibition across our ccRCC cell line panel, a result that is consistent with previously reported type I PRMT efficacy studies in other cancer types.
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PMC9429973
Of 9 patients in MR3 or better at asciminib initiation, 3 (33%) did not tolerate treatment, 2 (22%) maintained their response, and 4 (44%) deepened their response by one category or more.
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PMC10170482
Further, a recent study indicated that the cellular microenvironment mechanically regulates glycolysis.
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PMC2777936
It is likely that non-canonical Wnt pathways are functioning in human EC cells to maintain their cell division.
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PMC10142392
These properties are essential to defining the features and functions of liposomes in drug delivery applications .
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PMC11463018
Compound 19 was further evaluated against HDAC or JAK isozymes to determine selectivity profile, and the result was shown in Table 2.
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PMC9429973
Loss-of-function experiments using antisense oligonucleotides were performed on candidate chromatin-associated RNAs in AML cell lines, AML primary samples, and CD34 healthy bone marrow cells.
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PMC7812570
C Expression of CD4, CCR5, or CXCR4 on the surface of transduced CEMss-CCR5 cells, as evaluated by measuring the fluorescence intensity Expression of GPI-anchored antibodies fused with GFP in transduced human CD4+ T cells and their effects on CD4, CCR5, and CXCR4.
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PMC11794588
The filtrate was then evaporated using a rotary evaporator (BUCHI rotavapor R-100), and the weight of the first dried extract was determined.
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PMC11766309
The relationship between the YKT6 value and overall survival was investigated via the Kaplan‒Meier method, which is based on the survival and survminer R packages.
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PMC9429973
Results: The analyzed cohort consisted of 139 patients admitted to our institution between the years 2012-2018 with a median age of 46 years (range 4 months- 85 years).
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PMC9429973
9 additional cases showed another MECOM rearrangement (-rear) resulting in 46% (19/41) of patients with SF3B1 mutations accompanied by a MECOM-rear.
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PMC11727000
The abundance of the identified proteins was quantified and compared between cells expressing each construct.
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PMC8357004
5-Aza-CdR and TSA were purchased from Sigma (St. Louis, MO, USA) and dissolved in dimethyl sulfoxide (DMSO) to make a master stock solution.
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PMC11680391
The minimum and maximum agreement values of each of the five constructs are illustrated in Figure 2.
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PMC11216402
We chose gkm-SVM for this task because of its robust performance on small (differential accessibility) data sets and because it has been shown that gapped k-mers are efficient representations of TFBS (Ghandi et al. 2014b; Yan et al. 2021) and protein motifs (Amanchy et al. 2011).
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PMC11429241
Our findings show how the scaffold architecture design impacts tumor cell culture 3D spheroid formation, especially for the A2780 cancer cell line.
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