OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11587541	Moreover, significant attrition was also observed in severe form of SMA, i.e. SMA type 0 (P = 0.04) as well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10957991	Also, in endothelial cells, activation of Piezo1 by fluid shear stress initiates a calcium signal, leading to the opening of TRPV4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11352666	These data suggest that therapeutic strategies targeting MERTK may be particularly effective for the treatment of EWS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "suggest", "that", "therapeutic",...
PMC9429973	Treatment outcomes were measured in terms of response rate, overall survival (OS) and progression-free survival (PFS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "outcomes",...
PMC10759659	P < 0.05, P < 0.01, * P < 0.001) Previous studies have shown that ARID1A deficiency might impair the DNA mismatch repair (MMR) pathway , implying the underlying mechanism of increased mutagenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In the phase III ASCEMBL trial for adults with heavily pretreated CML-CP, asciminib (40 mg twice daily [BID]) had an improved major molecular response rate (25.5% vs 13.2%) at week 24 and a better safety profile compared with bosutinib (500 mg once daily).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754094	g, The effect of ART558 (POLQ inhibitor) reducing large-deletion frequencies in HeLa cells using long-range amplicon sequencing (n = 3, mean ± s.e.m.).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11194678	Lower: Statistic graph of quantified fold changes. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lower", ":", "Statistic", "graph", "of", "quantified", "fold", "changes", ".", "(" ] } ]
PMC9812014	Berberine was also found to inhibit the production of tumour necrosis factor-a (TNF-a) and prostaglandin E2 (PGE2) in H1N1 (PR8) infected cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...
PMC5417661	To confirm the mechanism of action of NOV202 in vitro the compound was tested in cell-free tubulin polymerization assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "confirm", "the", "mechanism...
PMC11352666	We show that MERTK is present on Ewing sarcoma cells and that MRX-2843 has therapeutic activity against these cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "show", "that", "MERTK", ...
PMC11001582	c, Panel shows representative image of Nissl staining of lumbar spinal cord in WT mice; the dashed red line delineates the sciatic motor pool in which motor neurons were counted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10587429	With careful design and optimization, this model is generalizable for other bone malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "careful", "design", "and", "optimization", ",", "this", ...
PMC8864075	Relative TWIST1 mRNA level after siRNA interference (n = 3). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "TWIST1", "mRNA", "level", "after", "siRNA", "interference", "("...
PMC11536589	Administration of PKF-118-310 markedly enhances the therapeutic efficacy of MRTX1133 in both in vitro and in vivo models of MRTX1133-resistant PDAC cells and tumors (Fig. 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11397654	The calixresorcinol derivatives 70a and 70b did not display any significant anticancer activity (IC50 > 50 µM) and did not show cytotoxicity against the healthy human cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2118063	In addition, staining for IRF8 was most intense in tonsillar germinal center (GC) dark-zone centroblasts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "staining", "for...
PMC11334037	Likewise, the Transwell assays found more migrating and invading OE-IGF2-GIST882 and GIST-T1 cells compared with their respective control cells (Figure 2D and E, P < 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731614	Combined fractions 2/3 were visualized with cryogenic-electron microscopy, demonstrating several diverse populations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Combined", "fractions", "2/3", "were", "visualized", "with", "cryogenic-electron"...
PMC11657695	p < 0,01; ****: p < 0,0001 and ns: not significant KCNA2 overexpression in ES biopsies correlates with patients’ survival rate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The screening methods used for DNA analysis, all performed in the National Thalassemia Centre, were denaturating gradient gel electrophoresis (DGGE), allele-spesific oligonucleotide (ASO) analysis, high resolution melting analysis and other polymerace chain reaction directed methods and DNA sequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11506827	However, the GEF-TRAIL combination significantly increased a proportion of apoptotic cells (early apoptosis and late apoptosis) in both cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However...
PMC3734024	We found that B cells were the predominant FasL-expressing lymphocyte population in the spleen, and while modestly enriched in the CD5CD1d B cell subset displayed a heterogeneous surface phenotype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731614	Using the same three databases as Fig. 4B, predicted target protein lists were obtained for each.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Using", "the", "same", "three", "databases", ...
PMC5925824	Modulation of the PD-1/PD-L1 axis through antagonist antibodies that block either receptor or ligand has been shown to reinvigorate the function of tumor-specific T cells and unleash potent anti-tumor immunity, leading to durable objective responses in a subset of patients across multiple tumor types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656657	Overall, our research provides compelling evidence supporting the use of GD2-targeted CAR T-cell therapy for pediatric sarcomas, emphasizing the importance of assessing GD2 expression levels and considering combinatory approaches to overcome resistance mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11082662	no. R233-01; Nanjing Vazyme Biotech Co., Ltd., Nanjing, China), ChamQ Universal SYBR qPCR Master Mix Kit (cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10899471	Statistical analysis of the negative correlation between miR-939-3p and BATF2 mRNA expression levels by using linear regression and Pearson correlation analysis. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11486946	Unlike screening methods that focus on a single event in the molecular process, our method can assess various physical events at the single-molecule level occurring during the signal transduction of the target molecule.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10253553	Relative protein levels for each sample were determined by interpolating each dilution curve produced from the densities of the 5-dilution sample spots using a standard curve (SuperCurve) for each slide (antibody).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473750	Normal disomy was defined as an average gene copy number between 1.20 and 2.40.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Normal", "disomy", "was", "defined", "as", "an", "average", "gen...
PMC10577955	The combined filtered ethanolic extract was evaporated under reduced pressure using a rotary evaporator at 40ºC to yield 75 gm of dried residue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11138140	The cultures were then transferred into a 37 °C and 5% CO2 incubator to acclimatize for an additional 1 h and reduce condensation on the well bottoms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612626	B, Effect of compound A on proteasome activator subunit levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ",", "Effect", "of", "compound", "A", "on", "proteasome", "activator", "subunit",...
PMC11615743	The mixture was then incubated at 65 °C for 30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mixture", "was", "then", "incubated", "at", "65", "°", "C", "for", ...
PMC9429973	Methods: Retrospective descriptive study.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Retrospective", "descriptive", "study", "." ] } ]
PMC9429973	Aims: To compare disease severity and mortality in a real-life cohort according to the vaccination status of patients diagnosed with hematologic malignancies developing COVID-19 disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11381192	Coincidentally, high CSI patients exhibit greater sensitivity to antimitotic agents like paclitaxel and vinorelbine, thereby advocating for the combination of existing therapies with antimitotic drugs to improve therapeutic efficacy for such patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3274243	The potential applications of the device were demonstrated by monitoring rheumatoid synovial fibroblasts (RSF) and HepG2 hepatocarcinoma cells in response to chemical and biological treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "...
PMC6182045	Denatured rgp120 was then mixed with reaction buffer and 5,000 units of enzyme and digests were incubated for 24 h at 37°C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC5810978	HuNoV replication levels observed in this study and by other groups [11, 15–18, 51] are still low compared to those achieved for murine NoVs and porcine SaVs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11588085	The expression analysis of ALDH1A3 revealed that clusters with low XIST expression had higher ALDH1A3 expression compared to those with high XIST expression (Fig. 6D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10366908	The Cell-Based Immunization and Screening (CBIS) method includes immunization with antigen-overexpressing cells and high-throughput hybridoma screening using flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Cell-Based", ...
PMC10778532	Cells were then washed in PBS (Gibco, Thermo Fisher Scientific, Inc., Waltham, MA, USA), fixed and stained during 30 min in a solution containing 25% methanol and 0.01% crystal violet (Sigma-Aldrich St Louis, MO, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Transient monosomy 7 with hematological recovery was observed in 2 patients and accompanied by gain of somatic rescuing mutations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transient", "monosomy", "7", "wit...
PMC11269792	On the other hand, the expression of most circRNAs is significantly correlated with GIST tumor size, mitotic number, and malignant degree by constructing circDNA expression profiles, and does not correlate with tumor site, but no experiments have been performed to verify this idea.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11087301	First, the activating transcription factor 3 gene is an adaptive-response gene that may act to combine stromal signaling pathways from the tumor niche with the acquisition of emerged EMT/CSC characteristics in mammary epithelial cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034	The driver ALK (purple coloring) is ranked as a top 3 kinase by INKA score, slightly below PTK2 and SRC.Data information: For each cell line, bar graphs depict kinase ranking based on kinase‐centric analyses (panel “Kinase phosphopeptides”), substrate‐centric analyses (panel “Substrate phosphopeptides”), and combined s...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11566417	a Results from qPCR analysis were plotted on a heatmap to show transcript expression in primary and immortalized lines at p10 and p20.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "a", ...
PMC9429973	Classification by degree of severity were: Non severe 9 patients (25%), severe 13 patients (36%), and very severe 14 patients (38%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11509278	The default criteria for differentially abundant metabolite screening are VIP > 1, p < 0.05, and FC ≥ 1.5 or FC ≤ 0.667.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11228511	The ability of progerin to trigger severe disease—despite ongoing lamin A synthesis—prompted speculation that progerin exerts a dominant-negative effect on the nuclear lamina (1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11400680	Although those conventional methods are simple and easy to use, many researchers accepted that they have limitations in human involvement for feature extraction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC4112127	The effect of BMP3 expression on the apoptosis of CC cells was assessed by caspase-3/7 activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "BMP3", "expression", "on", ...
PMC11261875	In a study conducted on 57 patients with GIST receiving neoadjuvant chemotherapy with imatinib, all patients exhibited detectable GLUT-4 levels before imatinib therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC8916024	When analyzed by group, it was found that the number of OTUs in the sediment sample (5,901.2 ± 182.9) was significantly higher than that in the juvenile (2,606.0 ± 121.7) and adult (2,895.7 ± 171.3) snail intestine samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11064533	Adhesion as clumps was rare, only observed for two E. coli strains, and more pronounced on the human urinary bladder cell line 5637 (10).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	However, DDX41 group and group associated with organ dysfunction presented a lower number of somatic mutations per patient (1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",...
PMC11190238	However, it is unclear whether these cohesin complex binding events would have impact on the local DNA looping since there were no chromatin conformation data available.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489351	Resulting RNA-Seq analysis can identify genes that are upregulated (magenta) or downregulated (cyan) compared to control MCF10A cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Resulting...
PMC9429973	The recruitment of NPM1c to chromatin is dependent on the nuclear exporter CRM1 as well as one of the acidic domains of NPM1c.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC10040136	TGF-β frequently assumes a crucial function in the interplay between MSC and tumors and exhibits intricate regulatory effects on both MSC and tumor cells and plays a crucial role in their interaction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767725	These enzymes degrade the extracellular matrix and follicular walls, allowing bacterial invasion and perpetuating tissue inflammation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "enzymes", "degrade", "the", "extracellul...
PMC6190245	A recent chemical analysis of Ferula species indicated the presence of diverse phytochemicals such as sesquiterpenes, sulfur-containing compounds, coumarin derivatives and sugars among the compounds isolated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10728200	The IHC staining score was expressed by the intensity multiplied by the proportional score.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "IHC", "staining", "score", "was", "expressed", "by", "the...
PMC11543935	A study by Bonnier et al. covers a comparison of the use in 2D and 3D cell cultures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "study", "by", "Bonnier", "et", ...
PMC8978939	Units of potential range from -7 to 7 kT/e (red, negative values; blue, positive values).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Units", "of", "potential", ...
PMC11317131	ddPCR was performed according to manufacturer's instructions (BioRad Laboratories).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ddPCR", "was", "performed", "according", "to", "manufacturer", "'s", "instructions", ...
PMC11772449	PFD may cooperate with Sora through a variety of ways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PFD", "may", "cooperate", "with", "Sora", "through", "a", "variety", "of", "ways", "." ...
PMC11766332	As such, a variety of genetic, epigenetic, and environmental factors may influence glycosylation, resulting in an extraordinary diversity of glycan structures linked to health and pathological conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11802929	All enrolled participants provided written in-person informed consent and samples were de-identified prior to analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "enrolled", "participants", "provided", "written", "in-pers...
PMC10154881	Number of GrBCD8 T cells (F) and IFN‐γCD8 T cells (G) in TDLNs from E.G‐7/N4‐bearing mice (left) and TDLNs from B16/N4‐bearing mice (right). *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787381	On the other hand, the ratio between the brain and the plasma concentrations is 4 times greater for bambuterol through the IN route (41%) compared to the IV route (10%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11762280	B Representative photos of mice receiving Ac-DEVD-CHO or PBS treatment 48 h after UVB exposure.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Representative", "photos", "of", "mice", "receiving", ...
PMC6642070	But it was interesting that β-enolase increased with fluvastatin treatment both dose- and time-dependently (Fig. 3a and 3b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "But", "it", "was", "in...
PMC11024707	In a recent study on a large sample of individuals with ASD, those with developmental delay, and normal control subjects, 14 mi-RNA levels in saliva were found to differ from those of control subjects, and the highest level of difference was found in mi-RNA 28-3p .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7762347	Relative quantification in accordance to the solvent control with an open web program quantGenius was used for data analysis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "quantification", "in", ...
PMC6163708	We determined the effect of a GLI inhibitor GANT61 on proliferation in 16 chosen cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "determined", "the", "effect", "of", "a", "...
PMC11291697	More details are available in Supplementary Tables S2 and S3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "details", "are", "available", "in", "Supplementary", "Tables", "S2", "and", "S3", ...
PMC11527437	Even when targeting a single antigen, TCR-T has mediated clinical responses in some patients, perhaps best exemplified by the FDA approval in August 2024 of the first-ever TCR-T product, which targets MAGE-A4, for patients with synovial sarcoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: The study included 132 patients (63 MM patients and 68 MGUS patients), who did not differ in age at the time of diagnosis, p = 0.089, the median age was 64.0 years (25% and 75% - 56.0 to 69, 0) and 61.0 years (25% and 75% - 53.0 and 66.0), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10932641	Abnormal expression of lncRNA has been shown to exhibit tumor-suppressive or oncogenic effects and plays an important role in tumor development (20).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11746948	Click chemistry reagents were added to the beads in the following order: 1 μl of 4 mM TAMRA azide (47130, Lumiprobe), 1.2 μl of 10 mM tris[(1-benzyl-1H-1,2,3-triazol-4-yl) methyl]amine (TBTA) (678937, Sigma-Aldrich), 1 μl of 40 mM CuSO4 (451657, Sigma-Aldrich), and 1 μl of 40 mM tris(2-carboxyethyl)phosphine HCl (TCEP ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770746	H & C NMR chemical shifts were referenced with the individual solvent residual peaks of respective NMR solvents used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H", "&", "C", "NMR", "chemi...
PMC9812014	The chemical structures of some of the antiviral alkaloids are given in Fig. 1.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "chemical", "structures", "of", "some", "of", "the", "anti...
PMC9429973	Moreover, cell cycle analysis revealed an increase of cells in sub-G1 phase – indicative of cell death induction – in the more sensitive cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11354225	The chelation of iron by EGCG decreases its availability, which, in conjunction with PpIX, forms the heme group catalyzed by the enzyme ferrochelatase (FECH), leading to increased accumulation of PpIX within the cell .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10033453	Three independent replicates of the assay were repeated per cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "independent", "replicates", "of", "the", "assay", "were", "repeated", "per", ...
PMC11543935	Inter-ablative thermometry was not feasible in the used setup due to electromagnetic interference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inter-ablative", "thermometry", "was", "not", "feasible", "in", "the", "use...
PMC11424574	The animal research was approved by the Animal Ethics Committee of Chung Shan Medical University (IACUC number: 2771).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "animal", "...
PMC11279598	Malignant and non-malignant control cells were seeded in 96-well plates at 2–3 × 10 cells/well in complete medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Malignant", "and", "non-malignant", "control...
PMC11127909	We found that the c-Myc levels in 143B-EFHD1 cells showed a smaller decrease than those in 143B-V cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "We", "found", "that", "the...
PMC4369959	In support of this study, recently Shamoto et al. showed that zerumbone blocks angiogenesis of pancreatic cancer cells through the inhibition of NF-κB and NF-κB-dependent proangiogenic gene products.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11775197	2The role of PPARβ/δ in CRC.↓ indicates inhibition and ↑ indicates increase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2The", "role", "of", "PPARβ/δ", "in", "CRC.↓", "indicates", "inhibition", "and",...
PMC8609870	We also observed the regulatory relationships between miRNA-mRNA and lncRNA-miRNA by Cytoscape 3.6.1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "observed", "the", "regulatory", "relationships", "between", "...
PMC8992508	Their cytotoxicity was evaluated in normal human colon fibroblasts (CCD18-Co), human gastric epithelial cell line and primary rat liver cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Despite the fact that in some patients with the maximum terms of cell suspension cryopreservation, the need for a larger number of doses of donor erythrocytes was recorded and there were longer terms for platelet recovery than in patients in the other two groups, the median values of the analyzed parameters did not dif...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7759933	On the other hand, newly developed hepatic three-dimensional (3D) cell models provide an attractive alternative, which, due to improved cell interactions and a higher level of liver-specific functions, including metabolic enzymes, reflect in vivo conditions more accurately.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11785489	TCR-mem associations hold after adjusting for Dextramer staining intensity (STAR Methods) as a proxy for TCR-pMHC affinity, which is thought to contribute to memory T cell development.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We next performed cell death assays by exposing ETP-ALL primary tumors to short-term treatment with venetoclax and navitoclax and found that consistent with BCL-2 dependence, adult ETP-ALL can be efficiently targeted for apoptosis via venetoclax.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11587541

Moreover, significant attrition was also observed in severe form of SMA, i.e. SMA type 0 (P = 0.04) as well.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC10957991

Also, in endothelial cells, activation of Piezo1 by fluid shear stress initiates a calcium signal, leading to the opening of TRPV4.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11352666

These data suggest that therapeutic strategies targeting MERTK may be particularly effective for the treatment of EWS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "suggest", "that", "therapeutic",...

PMC9429973

Treatment outcomes were measured in terms of response rate, overall survival (OS) and progression-free survival (PFS).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "outcomes",...

PMC10759659

P < 0.05, ** P < 0.01, *** P < 0.001) Previous studies have shown that ARID1A deficiency might impair the DNA mismatch repair (MMR) pathway , implying the underlying mechanism of increased mutagenesis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

In the phase III ASCEMBL trial for adults with heavily pretreated CML-CP, asciminib (40 mg twice daily [BID]) had an improved major molecular response rate (25.5% vs 13.2%) at week 24 and a better safety profile compared with bosutinib (500 mg once daily).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11754094

g, The effect of ART558 (POLQ inhibitor) reducing large-deletion frequencies in HeLa cells using long-range amplicon sequencing (n = 3, mean ± s.e.m.).

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PMC11194678

Lower: Statistic graph of quantified fold changes. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lower", ":", "Statistic", "graph", "of", "quantified", "fold", "changes", ".", "(" ] } ]

PMC9812014

Berberine was also found to inhibit the production of tumour necrosis factor-a (TNF-a) and prostaglandin E2 (PGE2) in H1N1 (PR8) infected cells .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", ...

PMC5417661

To confirm the mechanism of action of NOV202 in vitro the compound was tested in cell-free tubulin polymerization assay.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "confirm", "the", "mechanism...

PMC11352666

We show that MERTK is present on Ewing sarcoma cells and that MRX-2843 has therapeutic activity against these cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "show", "that", "MERTK", ...

PMC11001582

c, Panel shows representative image of Nissl staining of lumbar spinal cord in WT mice; the dashed red line delineates the sciatic motor pool in which motor neurons were counted.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10587429

With careful design and optimization, this model is generalizable for other bone malignancies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "careful", "design", "and", "optimization", ",", "this", ...

PMC8864075

Relative TWIST1 mRNA level after siRNA interference (n = 3). (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "TWIST1", "mRNA", "level", "after", "siRNA", "interference", "("...

PMC11536589

Administration of PKF-118-310 markedly enhances the therapeutic efficacy of MRTX1133 in both in vitro and in vivo models of MRTX1133-resistant PDAC cells and tumors (Fig. 8).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11397654

The calixresorcinol derivatives 70a and 70b did not display any significant anticancer activity (IC50 > 50 µM) and did not show cytotoxicity against the healthy human cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC2118063

In addition, staining for IRF8 was most intense in tonsillar germinal center (GC) dark-zone centroblasts.

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PMC11334037

Likewise, the Transwell assays found more migrating and invading OE-IGF2-GIST882 and GIST-T1 cells compared with their respective control cells (Figure 2D and E, P < 0.001).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11731614

Combined fractions 2/3 were visualized with cryogenic-electron microscopy, demonstrating several diverse populations.

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PMC11657695

p < 0,01; ****: p < 0,0001 and ns: not significant KCNA2 overexpression in ES biopsies correlates with patients’ survival rate.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The screening methods used for DNA analysis, all performed in the National Thalassemia Centre, were denaturating gradient gel electrophoresis (DGGE), allele-spesific oligonucleotide (ASO) analysis, high resolution melting analysis and other polymerace chain reaction directed methods and DNA sequencing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11506827

However, the GEF-TRAIL combination significantly increased a proportion of apoptotic cells (early apoptosis and late apoptosis) in both cell lines.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However...

PMC3734024

We found that B cells were the predominant FasL-expressing lymphocyte population in the spleen, and while modestly enriched in the CD5CD1d B cell subset displayed a heterogeneous surface phenotype.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11731614

Using the same three databases as Fig. 4B, predicted target protein lists were obtained for each.

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PMC5925824

Modulation of the PD-1/PD-L1 axis through antagonist antibodies that block either receptor or ligand has been shown to reinvigorate the function of tumor-specific T cells and unleash potent anti-tumor immunity, leading to durable objective responses in a subset of patients across multiple tumor types.

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PMC11656657

Overall, our research provides compelling evidence supporting the use of GD2-targeted CAR T-cell therapy for pediatric sarcomas, emphasizing the importance of assessing GD2 expression levels and considering combinatory approaches to overcome resistance mechanisms.

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PMC11082662

no. R233-01; Nanjing Vazyme Biotech Co., Ltd., Nanjing, China), ChamQ Universal SYBR qPCR Master Mix Kit (cat.

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PMC10899471

Statistical analysis of the negative correlation between miR-939-3p and BATF2 mRNA expression levels by using linear regression and Pearson correlation analysis. (

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PMC11486946

Unlike screening methods that focus on a single event in the molecular process, our method can assess various physical events at the single-molecule level occurring during the signal transduction of the target molecule.

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PMC10253553

Relative protein levels for each sample were determined by interpolating each dilution curve produced from the densities of the 5-dilution sample spots using a standard curve (SuperCurve) for each slide (antibody).

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PMC11473750

Normal disomy was defined as an average gene copy number between 1.20 and 2.40.

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PMC10577955

The combined filtered ethanolic extract was evaporated under reduced pressure using a rotary evaporator at 40ºC to yield 75 gm of dried residue.

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PMC11138140

The cultures were then transferred into a 37 °C and 5% CO2 incubator to acclimatize for an additional 1 h and reduce condensation on the well bottoms.

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PMC11612626

B, Effect of compound A on proteasome activator subunit levels.

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PMC11615743

The mixture was then incubated at 65 °C for 30 min.

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PMC9429973

Methods: Retrospective descriptive study.

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PMC9429973

Aims: To compare disease severity and mortality in a real-life cohort according to the vaccination status of patients diagnosed with hematologic malignancies developing COVID-19 disease.

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PMC11381192

Coincidentally, high CSI patients exhibit greater sensitivity to antimitotic agents like paclitaxel and vinorelbine, thereby advocating for the combination of existing therapies with antimitotic drugs to improve therapeutic efficacy for such patients.

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PMC3274243

The potential applications of the device were demonstrated by monitoring rheumatoid synovial fibroblasts (RSF) and HepG2 hepatocarcinoma cells in response to chemical and biological treatments.

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PMC6182045

Denatured rgp120 was then mixed with reaction buffer and 5,000 units of enzyme and digests were incubated for 24 h at 37°C.

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PMC5810978

HuNoV replication levels observed in this study and by other groups [11, 15–18, 51] are still low compared to those achieved for murine NoVs and porcine SaVs .

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PMC11588085

The expression analysis of ALDH1A3 revealed that clusters with low XIST expression had higher ALDH1A3 expression compared to those with high XIST expression (Fig. 6D).

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PMC10366908

The Cell-Based Immunization and Screening (CBIS) method includes immunization with antigen-overexpressing cells and high-throughput hybridoma screening using flow cytometry.

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PMC10778532

Cells were then washed in PBS (Gibco, Thermo Fisher Scientific, Inc., Waltham, MA, USA), fixed and stained during 30 min in a solution containing 25% methanol and 0.01% crystal violet (Sigma-Aldrich St Louis, MO, USA).

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PMC9429973

Transient monosomy 7 with hematological recovery was observed in 2 patients and accompanied by gain of somatic rescuing mutations.

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PMC11269792

On the other hand, the expression of most circRNAs is significantly correlated with GIST tumor size, mitotic number, and malignant degree by constructing circDNA expression profiles, and does not correlate with tumor site, but no experiments have been performed to verify this idea.

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PMC11087301

First, the activating transcription factor 3 gene is an adaptive-response gene that may act to combine stromal signaling pathways from the tumor niche with the acquisition of emerged EMT/CSC characteristics in mammary epithelial cells .

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PMC6461034

The driver ALK (purple coloring) is ranked as a top 3 kinase by INKA score, slightly below PTK2 and SRC.Data information: For each cell line, bar graphs depict kinase ranking based on kinase‐centric analyses (panel “Kinase phosphopeptides”), substrate‐centric analyses (panel “Substrate phosphopeptides”), and combined s...

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PMC11566417

a Results from qPCR analysis were plotted on a heatmap to show transcript expression in primary and immortalized lines at p10 and p20.

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PMC9429973

Classification by degree of severity were: Non severe 9 patients (25%), severe 13 patients (36%), and very severe 14 patients (38%).

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PMC11509278

The default criteria for differentially abundant metabolite screening are VIP > 1, p < 0.05, and FC ≥ 1.5 or FC ≤ 0.667.

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PMC11228511

The ability of progerin to trigger severe disease—despite ongoing lamin A synthesis—prompted speculation that progerin exerts a dominant-negative effect on the nuclear lamina (1).

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PMC11400680

Although those conventional methods are simple and easy to use, many researchers accepted that they have limitations in human involvement for feature extraction.

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PMC4112127

The effect of BMP3 expression on the apoptosis of CC cells was assessed by caspase-3/7 activity.

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PMC11261875

In a study conducted on 57 patients with GIST receiving neoadjuvant chemotherapy with imatinib, all patients exhibited detectable GLUT-4 levels before imatinib therapy.

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PMC8916024

When analyzed by group, it was found that the number of OTUs in the sediment sample (5,901.2 ± 182.9) was significantly higher than that in the juvenile (2,606.0 ± 121.7) and adult (2,895.7 ± 171.3) snail intestine samples.

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PMC11064533

Adhesion as clumps was rare, only observed for two E. coli strains, and more pronounced on the human urinary bladder cell line 5637 (10).

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PMC9429973

However, DDX41 group and group associated with organ dysfunction presented a lower number of somatic mutations per patient (1).

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PMC11190238

However, it is unclear whether these cohesin complex binding events would have impact on the local DNA looping since there were no chromatin conformation data available.

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PMC11489351

Resulting RNA-Seq analysis can identify genes that are upregulated (magenta) or downregulated (cyan) compared to control MCF10A cells.

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PMC9429973

The recruitment of NPM1c to chromatin is dependent on the nuclear exporter CRM1 as well as one of the acidic domains of NPM1c.

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PMC10040136

TGF-β frequently assumes a crucial function in the interplay between MSC and tumors and exhibits intricate regulatory effects on both MSC and tumor cells and plays a crucial role in their interaction.

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PMC11767725

These enzymes degrade the extracellular matrix and follicular walls, allowing bacterial invasion and perpetuating tissue inflammation .

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PMC6190245

A recent chemical analysis of Ferula species indicated the presence of diverse phytochemicals such as sesquiterpenes, sulfur-containing compounds, coumarin derivatives and sugars among the compounds isolated.

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PMC10728200

The IHC staining score was expressed by the intensity multiplied by the proportional score.

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PMC11543935

A study by Bonnier et al. covers a comparison of the use in 2D and 3D cell cultures.

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PMC8978939

Units of potential range from -7 to 7 kT/e (red, negative values; blue, positive values).

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PMC11317131

ddPCR was performed according to manufacturer's instructions (BioRad Laboratories).

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PMC11772449

PFD may cooperate with Sora through a variety of ways.

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PMC11766332

As such, a variety of genetic, epigenetic, and environmental factors may influence glycosylation, resulting in an extraordinary diversity of glycan structures linked to health and pathological conditions.

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PMC11802929

All enrolled participants provided written in-person informed consent and samples were de-identified prior to analysis.

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PMC10154881

Number of GrBCD8 T cells (F) and IFN‐γCD8 T cells (G) in TDLNs from E.G‐7/N4‐bearing mice (left) and TDLNs from B16/N4‐bearing mice (right). *

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PMC11787381

On the other hand, the ratio between the brain and the plasma concentrations is 4 times greater for bambuterol through the IN route (41%) compared to the IV route (10%).

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PMC11762280

B Representative photos of mice receiving Ac-DEVD-CHO or PBS treatment 48 h after UVB exposure.

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PMC6642070

But it was interesting that β-enolase increased with fluvastatin treatment both dose- and time-dependently (Fig. 3a and 3b).

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PMC11024707

In a recent study on a large sample of individuals with ASD, those with developmental delay, and normal control subjects, 14 mi-RNA levels in saliva were found to differ from those of control subjects, and the highest level of difference was found in mi-RNA 28-3p .

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PMC7762347

Relative quantification in accordance to the solvent control with an open web program quantGenius was used for data analysis .

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PMC6163708

We determined the effect of a GLI inhibitor GANT61 on proliferation in 16 chosen cell lines.

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PMC11291697

More details are available in Supplementary Tables S2 and S3.

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PMC11527437

Even when targeting a single antigen, TCR-T has mediated clinical responses in some patients, perhaps best exemplified by the FDA approval in August 2024 of the first-ever TCR-T product, which targets MAGE-A4, for patients with synovial sarcoma.

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PMC9429973

Results: The study included 132 patients (63 MM patients and 68 MGUS patients), who did not differ in age at the time of diagnosis, p = 0.089, the median age was 64.0 years (25% and 75% - 56.0 to 69, 0) and 61.0 years (25% and 75% - 53.0 and 66.0), respectively.

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PMC10932641

Abnormal expression of lncRNA has been shown to exhibit tumor-suppressive or oncogenic effects and plays an important role in tumor development (20).

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PMC11746948

Click chemistry reagents were added to the beads in the following order: 1 μl of 4 mM TAMRA azide (47130, Lumiprobe), 1.2 μl of 10 mM tris[(1-benzyl-1H-1,2,3-triazol-4-yl) methyl]amine (TBTA) (678937, Sigma-Aldrich), 1 μl of 40 mM CuSO4 (451657, Sigma-Aldrich), and 1 μl of 40 mM tris(2-carboxyethyl)phosphine HCl (TCEP ...

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PMC11770746

H & C NMR chemical shifts were referenced with the individual solvent residual peaks of respective NMR solvents used.

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PMC9812014

The chemical structures of some of the antiviral alkaloids are given in Fig. 1.Fig.

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PMC9429973

Moreover, cell cycle analysis revealed an increase of cells in sub-G1 phase – indicative of cell death induction – in the more sensitive cell lines.

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PMC11354225

The chelation of iron by EGCG decreases its availability, which, in conjunction with PpIX, forms the heme group catalyzed by the enzyme ferrochelatase (FECH), leading to increased accumulation of PpIX within the cell .

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PMC10033453

Three independent replicates of the assay were repeated per cell line.

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PMC11543935

Inter-ablative thermometry was not feasible in the used setup due to electromagnetic interference.

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PMC11424574

The animal research was approved by the Animal Ethics Committee of Chung Shan Medical University (IACUC number: 2771).

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PMC11279598

Malignant and non-malignant control cells were seeded in 96-well plates at 2–3 × 10 cells/well in complete medium.

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PMC11127909

We found that the c-Myc levels in 143B-EFHD1 cells showed a smaller decrease than those in 143B-V cells.

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PMC4369959

In support of this study, recently Shamoto et al. showed that zerumbone blocks angiogenesis of pancreatic cancer cells through the inhibition of NF-κB and NF-κB-dependent proangiogenic gene products.

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PMC11775197

2The role of PPARβ/δ in CRC.↓ indicates inhibition and ↑ indicates increase.

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PMC8609870

We also observed the regulatory relationships between miRNA-mRNA and lncRNA-miRNA by Cytoscape 3.6.1.

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PMC8992508

Their cytotoxicity was evaluated in normal human colon fibroblasts (CCD18-Co), human gastric epithelial cell line and primary rat liver cells.

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PMC9429973

Despite the fact that in some patients with the maximum terms of cell suspension cryopreservation, the need for a larger number of doses of donor erythrocytes was recorded and there were longer terms for platelet recovery than in patients in the other two groups, the median values of the analyzed parameters did not dif...

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PMC7759933

On the other hand, newly developed hepatic three-dimensional (3D) cell models provide an attractive alternative, which, due to improved cell interactions and a higher level of liver-specific functions, including metabolic enzymes, reflect in vivo conditions more accurately.

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PMC11785489

TCR-mem associations hold after adjusting for Dextramer staining intensity (STAR Methods) as a proxy for TCR-pMHC affinity, which is thought to contribute to memory T cell development.

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PMC9429973

We next performed cell death assays by exposing ETP-ALL primary tumors to short-term treatment with venetoclax and navitoclax and found that consistent with BCL-2 dependence, adult ETP-ALL can be efficiently targeted for apoptosis via venetoclax.

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