OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11343332	Cell migration analyzed by scratch wound healing assay Human breast cancer cell lines (2×105 cells/well) were seeded onto six-well culture plates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11718274	14.94 and 28.89 µg/ml) for 72 h .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "14.94", "and", "28.89", "µg/ml", ")", "for", "72", "h", "." ] } ]
PMC9351137	For immunoprecipitation, rabbit polyclonal antibodies (Abcam) against BAF53a or Tip60 were used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "immunoprecipitation", ",", "rabbit", "polyclonal", "antibo...
PMC10380508	Briefly, cells were trypsinized, washed in PBS, and lysed on ice for 30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "cells", "were", "trypsinized", ...
PMC11335267	As Syb-2 is a general component of the SNARE complex mediating vesicle exocytosis from nerve terminals, reduced gastrocnemius innervation may involve both sympathetic and motor neuron terminals, as attested by the observed decrease in the levels of ChAT, a protein that is specific for cholinergic neurons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11463018	Chidamide (4), an ortho-aminoaniline inhibitor, was approved for treating recurrent and refractory peripheral T-cell lymphoma by the China Food and Drug Administration in 2015.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Recent studies explored mitochondrial alterations contributing to metabolic vulnerability in myeloid leukemia cells may considered as therapeutic targets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "explored", "mitochondri...
PMC11706776	Some potassium channels have thus been shown to be involved in gastrointestinal cancer , colorectal cancer or myeloma .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "potassium", "channels", "have", ...
PMC11724582	Cells were seeded into 6-well plates at a density of 2000 cells per well and incubated for 24 h. The medication-containing substance was then replaced.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC10530622	The putative involvement of mitochondrial kynurenine aminotransferase-III in glyoxylate-to-glycine conversion was also recently postulated and merits careful further examination .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "putative", "involvement", ...
PMC6889484	All transfections were performed using TransIT-LT1 Transfection Reagent (Mirus Bio, Madison, WI, USA) according to the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11768927	Concerns regarding VSV’s neurotoxicity can be addressed through genetic modifications, such as the substitution of the G protein or the use of attenuated mutants like MΔ51 or M51R , which retain oncolytic activity while improving safety profiles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9250505	Stable pooled A2780-Vector and A2780-BAD-knock out (KO) cells using CRISPR-CAS9 (Supplementary Methods) mediated deletion of the BAD gene were generated in A2780 cells to confirm the specificities of the pBADS99 and BAD antibodies (Supplementary Fig. 8C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In the Phase 1/2 Study CIRM-0001, ZILO in combination with Ibr was well tolerated and demonstrated promising efficacy in heavily pretreated, relapsed and refractory (R/R) patients (pts) with mantle cell lymphoma (MCL).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: Eleven pts with R/R MM were enrolled and underwent apheresis during June 9, 2021 and February 25, 2022.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":...
PMC10936243	because one of my limitations also is our clinic, we are not 24 hours” [D072].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "because", "one", "of", "my", ...
PMC7724160	Mobile phases were acetonitrile and 50 mM ammonium formate, at pH 4.4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mobile", "phases", "were", "acetonitrile", "and", "50", "mM", "ammonium", ...
PMC4360730	Further, the curation of all ENCODE metadata has led to enhancement of the ontologies and thus increasing their usefulness to the community.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further...
PMC9412887	In addition to the resistance mechanisms mentioned above, autophagy and inactivation of apoptosis are also considered be responsible for drug resistance to targeted anticancer agents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11544122	No detectable BRET response was measured in cells transfected with Rluc8-SNX9 or SNX9-RlucII alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "detectable", "BRET", "response", "was", "measured", "in", ...
PMC8996378	This review article summarizes and discusses the research progress on diterpenoids in reversing MDR.Cancer, one of major public health problems, imposes a serious challenge to the survival of human beings worldwide (Wu et al., 2019).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634027	Localization and levels of Ds protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Localization", "and", "levels", "of", "Ds", "protein", "." ] } ]
PMC11247842	For METAL, we followed recommendations from EasyQC’s protocol .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "METAL", ",", "we", "followed", "recommendations", "from", "EasyQC", "’s", "protocol", ...
PMC11322866	Second, RRM2 overexpression downregulates EZH2 and inhibits its methyltransferase function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Second", ",", "RRM2", "overexpression", "downregulates", "EZH2", "and", "inhibits", "its", ...
PMC11791203	The panels show: (A-I) HT29 DMSO control, stained with AO; (A-II) HT29 DMSO control, stained with EB; (A-III) HT29 DMSO control, overlay of AO and EB; (B-I) HT29 treated with 31.30 µg/mL extract, stained with AO; (B-II) HT29 treated with 31.30 µg/mL extract, stained with EB; (B-III) HT29 treated with 31.30 µg/mL extrac...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "...
PMC11684297	100$$ Each experiment was done in triplicates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "100$$", "Each", "experiment", "was", "done", "in", "triplicates", "." ] } ]
PMC11244823	The second half of each gel was stained by Coomassie blue using Imperial protein stain (ThermoFisher Scientific) and imaged at Li-COR Odyssey M Imaging System.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748335	As a corollary, these data imply that in tumors, due to the most significant decrease in DNA methylation levels in the L-PMDs, more inhibitive markers are supplemented, leading to the redistribution of H3K27me3 long LOCKs from S- to I- and L-PMDs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8336407	HepG2 cell line was purchased from Pasteur institute-Iran.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HepG2", "cell", "line", "was", "purchased", "from", "Pasteur", "institute-Iran", "." ] } ]
PMC11740207	However, due to cytological differences, including cell size, it remains unclear whether LT-HSCs represent more differentiated stages derived from VSELSCs, with their leukemic in vitro equivalents potentially being SLSLCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11698348	While Elf5 overexpression leads to G0 arrest compared to controls cells (Fig 3e).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "Elf5", "overexpression", "leads", "to", "G0", "arr...
PMC9429973	Primary outcome was clinical improvement defined as mortality or whether discharged alive or improvement in WHO 6-point severity scale within 28 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Primary", "o...
PMC11345828	Using this paradigm, the plasma protein binding in mouse was found to be approximately equal to human, the plasma protein binding for dog and minipig were ∼2-fold lower than in human, and rat exhibited a 3-fold lower binding than human.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10547921	Finally, in view of the limitations of the current payloads, the main research directions for developing future ADC payloads are discussed, with the hope to provide a reference for the future design of novel ADC payloads with ideal characteristics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10055960	For cytotoxicity testing, the cells were seeded on 96-well Nunclon Delta surface assay plates (from Thermo Scientific, Waltham, USA); in addition to in wells containing 190 µL cell suspensions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11783017	H&E staining of lung tissue. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "H&E", "staining", "of", "lung", "tissue", ".", "(" ] } ]
PMC11407042	Note: The dilution depends on the CFU corresponding to an OD600 of 1.0, and the number of A549 cells in the 96-well plate after incubation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", ...
PMC5941560	Our bottom-up analysis was mostly limited by the availability of variant effect information.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "bottom-up", "analysis", "was", "mostly", "limited", "by", "the", ...
PMC8427838	Coomassie Blue stain of GST, GST-FERM and GST-C-ERMAD in Whole Cell Lysate (WCL) or pulled-down proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Coomassie", "Blue", "stain", "of"...
PMC11623887	The tests were performed in triplicate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "tests", "were", "performed", "in", "triplicate", "." ] } ]
PMC10933092	These data indicate that mA methylation participates in cancer progression by modulating cancer-related mRNAs, lncRNAs, and miRNAs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "indicate", "that...
PMC5874706	All these observations also indicate that the THN7 molecule should be located between the hydrophobic chains rather than in the cyclodextrin cavity, as the molecule is too bulky to fit into the cavity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11764090	CsWRKY46 enhances cold resistance via an ABA-dependent pathway (Table 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CsWRKY46", "enhances", "cold", "resistance", "via", "an", "ABA-dependent", "pathway", ...
PMC9918897	Gradients: from 0 to 42 min, mobile phase B increased linearly from 35% to 95%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gradients", ":", "from", "0", ...
PMC11721295	Data were normalized using the NormalizeData function with a scale factor of 10,000 and the LogNormalize normalization method.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "normalized", "using", ...
PMC11411131	The expression of full-length C322U was enhanced by sodium selenite treatment (at concentrations of 10, 30, and 100 nM), but the ratio of the full-length form to the total amount was still minimal (Fig. 4D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11496728	Fig. 2Effect of the addition of regulatory elements on the transient and stable expression of recombinant proteins. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "2Effect", "of", "the", "additi...
PMC9622879	However, the community with the proposed CEMS sells more energy than the community with the prosumer-centric CEMS at high-price time slots (e.g., time slots 17 and 18).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5308810	The real-time PCR analysis also confirmed that CXCR4 expressed lower levels of epithelial markers, including E-cadherin and Occludin, and higher levels of mesenchymal markers, including Fibronectin, Snail, N-cadherin, Twist, Zeb1, Zeb2, and Vimentin (Fig 2H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11757230	CADSCs were co-cultured with canine lymphoma/leukemia cell lines of various lineages, with or without cell-to-cell contact, to evaluate their effects on proliferation, apoptosis, and cell cycle progression in vitro.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11618052	Also, compounds 8k (R1 = m-tolyl, R2 = OMe) and 8l (R1 = m-tolyl, R2 = Me) had GI50 values of 43 and 33 nM, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11587606	Fig. 5Schematic representation of RHBDF1-promoted destruction of mammary epithelial cell apicobasal polarity and cell-cell connections Schematic representation of RHBDF1-promoted destruction of mammary epithelial cell apicobasal polarity and cell-cell connections Additionally, our data indicate that RHBDF1 overexpressi...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754291	Differential Effects of UVA and Blue Light on Keratinocyte Morphology and Cytotoxicity We observed a distinct difference between the effects of UVA and blue light (Figure 7), which highlighted the boundary between non-ionizing and ionizing radiation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591794	Ou et al. explained the ability of GA to induce G2/M arrest by changes in cell cycle regulators in the human bladder transitional carcinoma cell line .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11314247	In this study, apoptosis was determined via flow cytometry using the FITC Annexin V Apoptosis Detection Kit (Roche Molecular Biochemicals, Basel, Switzerland) for a short and a long time based on Mawatari et al.’s work, in which they determined that VPA initiates histone acetylation and apoptosis before 6 h of treatmen...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10993311	Another study that sought to identify the methylation profile in DNAm datasets obtained from the GEO database in obesity found methylation-regulated differentially expressed genes, which are involved in the molecular function of fatty acids (Duarte et al., 2023), as highlighted in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5810978	Caco-2 cells have been widely used for HuNoV culture trials and most research groups including our group could not grow HuNoV previously [31, 47–49].	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8584319	Thus, our results suggest that ERK and p38 are closely related to the translation machinery through the regulation of 4E-BP1 mRNA expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ...
PMC9429973	Image: Summary/Conclusion: Among all factors studied we found that refractory anemia, unfavourable karyotype and higher risk group according to DIPSS scoring are the most important factors affecting the disease progression and overall survival with statistically significant difference.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740907	The cells were treated with a 0.4% w/v solution of SRB dye for a duration of 30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cells", "were", "treated",...
PMC6034753	Immunoprecipitation was then carried out using DF-1 cells co-transfected with Meq and N-terminal tagged FLAG-Apoptin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunoprecipitation", "was", "then", "carried", "out", "...
PMC11088135	p < 0.01 vs. control-siRNA; p < 0.01 vs. inhibitor control; p < 0.01 vs. NUTM2A-AS1-siRNA + inhibitor control Next, we analyzed the effects of lncRNA NUTM2A-AS1 on the proliferation and apoptosis of U251 cells by loss-function experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7171147	The Seahorse XF FAO assay and the XF glycolysis stress assay were performed using a Seahorse XFp analyzer (Agilent) according to the manufacturer’s protocols.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4369959	However, they found a significant decrease in PGE2 and 5-hydroxyeicosatetraenoic acid (HETE) and a trend toward significant decrease in 12-HETE and 15-HETE normalized to free arachidonic acid .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594074	The 3D structures of the ligands were downloaded from the ZINC15 database (https://zinc15.docking.org, accessed on 27 November 2022), and the crystal structure of DNMT1 was downloaded from the Protein Data Bank (https://www.rcsb.org, accessed on 9 February 2023) (PDB code 4WXX).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11291490	It is generally recognized that IFNγ dependent Th1, besides neutralizing antibodies, responses are necessary to prevent Flavivirus infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "generally", ...
PMC11541409	: p. e1881.This reference is of importance because clearly demonstrates that ALK mutation is one of the oncogenes that contribute to the drug resistance of wild-type GIST in the clinical setting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4355729	In our study, the expression of NCAD, VIM and ZEB1 was elated in the cells with the downregulation of PIK3R1, whereas the expression of ECAD was decreased in these cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4112127	We aimed to quantitatively assess BMP3 methylation in resected CC tumor specimens using methylation specific PCR and evaluate the tumor suppressor role of BMP3 in biliary cancer cell lines in comparison to an immortalized normal cholangiocyte cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Combination of CD20-TCB with a CD19-4-1BBL fusion protein (tumor-targeted co-stimulatory drug) resulted in enhanced CLL cell killing in both T:CLL and triple T:CLL-EC culture assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656380	100% LDH leakage was determined in 0.2% (w/v) Tween 20.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "100", "%", "LDH", "leakage", "was", "determined", "in", "0.2", ...
PMC7452526	It could be adsorbed on the surface of AgNPs enabling their reduction from Ag and preventing them from agglomeration .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "could", "be", "adsorbed", ...
PMC10698968	Also in this case, NCC-MFS1-C1 cell line has a more resistant phenotype to this drug than that of MF-R 3 to doxorubicin and epirubicin.	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O"...
PMC11734514	Figure 3Jak/Stat Signaling Protein expression (PTEN, AKT, p-AKT, p-mTOR, and STAT-3) in A549 cells treated with C. aerizusa. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ],...
PMC10847511	Platinum agents (shown in the top panel) and PARP inhibitors (shown in the second panel) exhibiting a trend for positive or negative differences (unadjusted P < 0.05) between the two groups are highlighted in red and blue font, respectively, and those remained statistically significant (adjusted P < 0.05) after multipl...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11727145	The evaluation of different stages of burn wound exudation could be performed to further develop the DED model as a functional testing platform for cutaneous cellular therapies and different combinations of physiological skin cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11257203	Briefly, tris buffer was added to 1 mL of each homogenate sample (treated lymphocytes/mice bone marrow) and vortexed for 1 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC2614416	Gene ontology (Michael Ashburner ) analyses are carried out with Blast2GO ; a java webstart-enabled Gene Ontology annotation, visualization and analysis program.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11585994	We then investigated the potential anti-leukemia effect of nanoparticle formulation in T-ALL PDX mouse model (Figure 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "then", "investigated", "the...
PMC11659921	Additionally, we assessed the distribution proportions of various CNV categories—heterozygous amplification, heterozygous deletion, homozygous amplification, and homozygous deletion—among angiogenesis‐ and stemness‐related genes in OV patients (Figure 2C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4355729	The fragments were determined by Sanger sequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fragments", "were", "determined", "by", "Sanger", "sequencing", "." ] } ]
PMC10761571	Based on this study, Fe3O4@Glu-Gingerol remarkably promoted the expression of the proapoptotic genes, CASP8 and BAX.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Based", "on", "this", "study", ",", ...
PMC11759543	Symbols ∗ and # were compared with control and Z- LEHD-FMK only, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Symbols", "∗", "and", "#", "were", "compared", "with", "control"...
PMC9429973	15 thrombotic events (14 hospital control vs 1 in remote control).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "15", "thrombotic", "events", "(", "14", "hospital", "control", "vs", ...
PMC9429973	We found no association with age, sex, central nervous system infiltration, or leukocyte count.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "found", "no", "association", "with", ...
PMC11349530	In particular, not only VEGF affects angiogenesis, but also many of the other factors are capable of angiogenesis upregulation [for instance, IL-6 (38), TNF (39), IL-33 (40), MCP-1/CCL2 (41), IL-8/CXCL10 (42), kynurenine (43), adenosine (44)].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11488203	In certain neoplastic developments miRs can be dysregulated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "certain", "neoplastic", "developments", "miRs", "can", "be", "dysregulated", "." ] } ]
PMC11650848	Increases in beta band power can be seen when physical movement is successfully cancelled, while planning movements or executing movements decreases beta power in the brain .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10523483	Verification of H1.2 knockout in A549 cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Verification", "of", "H1.2", "knockout", "in", "A549", "cells", ".", "(" ] } ]
PMC9917080	Increased expression of glutathione reductases and thioredoxin peroxidases after exposure to SeNPs and SeSo can be considered an activation of the antioxidant systems of astrocytes in the cerebral cortex.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11025866	Since xCT is overexpressed in a number of malignancies, inhibition of xCT is one therapeutic strategy for treatment of these cancers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Since", "xCT...
PMC7192625	Comparison of PCHi-C and Hi-C networks. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Comparison", "of", "PCHi-C", "and", "Hi-C", "networks", ".", "(" ] } ]
PMC11730320	The variant removes the core promoter, the transcription start site, the translation start site and subsequent protein sequence encoded by the first exon of PTCRA, thus very likely resulting in complete loss-of-function (Fig. 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9895440	Controls without T cells (maximal signal) and one with 0.1% Triton-X100 (minimal signal) were used to calculate % specific lysis:[12pt] $$\%\,\,=(1-(-\,}\,-\,})) 100\%$$%specificlysis=1−signal−minimalsignalmaixmalsignal−minimalsignal×100% To measure proliferation and stability after repetitive stimulation, cells on day...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878562	In many solid cancers altered expression levels of ACKR3 correlate with poor prognosis and tumor metastasis (22–29).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "many", "solid", "cancers", ...
PMC11422497	Despite this, the availability of effective tumor biomarkers for GISTs diagnosis and prognostication remains limited.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "this", ",", "the", "availability", "of", ...
PMC9429973	Of note, PTK2B was highly expressed in leukemic stem cells (LSCs) from FLT3-ITD mutated patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Of", "note", ",", "PTK2B", "was", ...
PMC11188874	After 12 hours, cells were washed with FACS buffer twice and stained with annexin-V conjugated with FITC and anti-CD8 conjugated with APC (BD Biosciences, BDB553035).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676670	The main genetic characteristics of HGSOC include TP53 mutations, homologous recombination deficiency, and a high level of genomic alterations .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "main", "ge...
PMC11718109	We now demonstrate that DA nerve terminals show three pools of secretory vesicles: SSVs, large empty vesicles and DCVs in iPSC-derived DA neurons and synaptosomes from DA nerve terminals of mouse striata.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11343332

Cell migration analyzed by scratch wound healing assay Human breast cancer cell lines (2×105 cells/well) were seeded onto six-well culture plates.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11718274

14.94 and 28.89 µg/ml) for 72 h .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "14.94", "and", "28.89", "µg/ml", ")", "for", "72", "h", "." ] } ]

PMC9351137

For immunoprecipitation, rabbit polyclonal antibodies (Abcam) against BAF53a or Tip60 were used.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "immunoprecipitation", ",", "rabbit", "polyclonal", "antibo...

PMC10380508

Briefly, cells were trypsinized, washed in PBS, and lysed on ice for 30 min.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "cells", "were", "trypsinized", ...

PMC11335267

As Syb-2 is a general component of the SNARE complex mediating vesicle exocytosis from nerve terminals, reduced gastrocnemius innervation may involve both sympathetic and motor neuron terminals, as attested by the observed decrease in the levels of ChAT, a protein that is specific for cholinergic neurons.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11463018

Chidamide (4), an ortho-aminoaniline inhibitor, was approved for treating recurrent and refractory peripheral T-cell lymphoma by the China Food and Drug Administration in 2015.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Recent studies explored mitochondrial alterations contributing to metabolic vulnerability in myeloid leukemia cells may considered as therapeutic targets.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "explored", "mitochondri...

PMC11706776

Some potassium channels have thus been shown to be involved in gastrointestinal cancer , colorectal cancer or myeloma .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "potassium", "channels", "have", ...

PMC11724582

Cells were seeded into 6-well plates at a density of 2000 cells per well and incubated for 24 h. The medication-containing substance was then replaced.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC10530622

The putative involvement of mitochondrial kynurenine aminotransferase-III in glyoxylate-to-glycine conversion was also recently postulated and merits careful further examination .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "putative", "involvement", ...

PMC6889484

All transfections were performed using TransIT-LT1 Transfection Reagent (Mirus Bio, Madison, WI, USA) according to the manufacturer’s instructions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11768927

Concerns regarding VSV’s neurotoxicity can be addressed through genetic modifications, such as the substitution of the G protein or the use of attenuated mutants like MΔ51 or M51R , which retain oncolytic activity while improving safety profiles.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9250505

Stable pooled A2780-Vector and A2780-BAD-knock out (KO) cells using CRISPR-CAS9 (Supplementary Methods) mediated deletion of the BAD gene were generated in A2780 cells to confirm the specificities of the pBADS99 and BAD antibodies (Supplementary Fig. 8C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

In the Phase 1/2 Study CIRM-0001, ZILO in combination with Ibr was well tolerated and demonstrated promising efficacy in heavily pretreated, relapsed and refractory (R/R) patients (pts) with mantle cell lymphoma (MCL).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Results: Eleven pts with R/R MM were enrolled and underwent apheresis during June 9, 2021 and February 25, 2022.

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PMC10936243

because one of my limitations also is our clinic, we are not 24 hours” [D072].

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PMC7724160

Mobile phases were acetonitrile and 50 mM ammonium formate, at pH 4.4.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mobile", "phases", "were", "acetonitrile", "and", "50", "mM", "ammonium", ...

PMC4360730

Further, the curation of all ENCODE metadata has led to enhancement of the ontologies and thus increasing their usefulness to the community.

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PMC9412887

In addition to the resistance mechanisms mentioned above, autophagy and inactivation of apoptosis are also considered be responsible for drug resistance to targeted anticancer agents.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11544122

No detectable BRET response was measured in cells transfected with Rluc8-SNX9 or SNX9-RlucII alone.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "detectable", "BRET", "response", "was", "measured", "in", ...

PMC8996378

This review article summarizes and discusses the research progress on diterpenoids in reversing MDR.Cancer, one of major public health problems, imposes a serious challenge to the survival of human beings worldwide (Wu et al., 2019).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11634027

Localization and levels of Ds protein.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Localization", "and", "levels", "of", "Ds", "protein", "." ] } ]

PMC11247842

For METAL, we followed recommendations from EasyQC’s protocol .

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PMC11322866

Second, RRM2 overexpression downregulates EZH2 and inhibits its methyltransferase function.

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PMC11791203

The panels show: (A-I) HT29 DMSO control, stained with AO; (A-II) HT29 DMSO control, stained with EB; (A-III) HT29 DMSO control, overlay of AO and EB; (B-I) HT29 treated with 31.30 µg/mL extract, stained with AO; (B-II) HT29 treated with 31.30 µg/mL extract, stained with EB; (B-III) HT29 treated with 31.30 µg/mL extrac...

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PMC11684297

100$$ Each experiment was done in triplicates.

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PMC11244823

The second half of each gel was stained by Coomassie blue using Imperial protein stain (ThermoFisher Scientific) and imaged at Li-COR Odyssey M Imaging System.

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PMC11748335

As a corollary, these data imply that in tumors, due to the most significant decrease in DNA methylation levels in the L-PMDs, more inhibitive markers are supplemented, leading to the redistribution of H3K27me3 long LOCKs from S- to I- and L-PMDs.

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PMC8336407

HepG2 cell line was purchased from Pasteur institute-Iran.

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PMC11740207

However, due to cytological differences, including cell size, it remains unclear whether LT-HSCs represent more differentiated stages derived from VSELSCs, with their leukemic in vitro equivalents potentially being SLSLCs.

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PMC11698348

While Elf5 overexpression leads to G0 arrest compared to controls cells (Fig 3e).

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PMC9429973

Primary outcome was clinical improvement defined as mortality or whether discharged alive or improvement in WHO 6-point severity scale within 28 days.

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PMC11345828

Using this paradigm, the plasma protein binding in mouse was found to be approximately equal to human, the plasma protein binding for dog and minipig were ∼2-fold lower than in human, and rat exhibited a 3-fold lower binding than human.

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PMC10547921

Finally, in view of the limitations of the current payloads, the main research directions for developing future ADC payloads are discussed, with the hope to provide a reference for the future design of novel ADC payloads with ideal characteristics.

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PMC10055960

For cytotoxicity testing, the cells were seeded on 96-well Nunclon Delta surface assay plates (from Thermo Scientific, Waltham, USA); in addition to in wells containing 190 µL cell suspensions.

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PMC11783017

H&E staining of lung tissue. (

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PMC11407042

Note: The dilution depends on the CFU corresponding to an OD600 of 1.0, and the number of A549 cells in the 96-well plate after incubation.

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PMC5941560

Our bottom-up analysis was mostly limited by the availability of variant effect information.

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PMC8427838

Coomassie Blue stain of GST, GST-FERM and GST-C-ERMAD in Whole Cell Lysate (WCL) or pulled-down proteins.

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PMC11623887

The tests were performed in triplicate.

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PMC10933092

These data indicate that mA methylation participates in cancer progression by modulating cancer-related mRNAs, lncRNAs, and miRNAs.

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PMC5874706

All these observations also indicate that the THN7 molecule should be located between the hydrophobic chains rather than in the cyclodextrin cavity, as the molecule is too bulky to fit into the cavity.

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PMC11764090

CsWRKY46 enhances cold resistance via an ABA-dependent pathway (Table 2).

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PMC9918897

Gradients: from 0 to 42 min, mobile phase B increased linearly from 35% to 95%.

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PMC11721295

Data were normalized using the NormalizeData function with a scale factor of 10,000 and the LogNormalize normalization method.

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PMC11411131

The expression of full-length C322U was enhanced by sodium selenite treatment (at concentrations of 10, 30, and 100 nM), but the ratio of the full-length form to the total amount was still minimal (Fig. 4D).

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PMC11496728

Fig. 2Effect of the addition of regulatory elements on the transient and stable expression of recombinant proteins. (

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PMC9622879

However, the community with the proposed CEMS sells more energy than the community with the prosumer-centric CEMS at high-price time slots (e.g., time slots 17 and 18).

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PMC5308810

The real-time PCR analysis also confirmed that CXCR4 expressed lower levels of epithelial markers, including E-cadherin and Occludin, and higher levels of mesenchymal markers, including Fibronectin, Snail, N-cadherin, Twist, Zeb1, Zeb2, and Vimentin (Fig 2H).

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PMC11757230

CADSCs were co-cultured with canine lymphoma/leukemia cell lines of various lineages, with or without cell-to-cell contact, to evaluate their effects on proliferation, apoptosis, and cell cycle progression in vitro.

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PMC11618052

Also, compounds 8k (R1 = m-tolyl, R2 = OMe) and 8l (R1 = m-tolyl, R2 = Me) had GI50 values of 43 and 33 nM, respectively.

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PMC11587606

Fig. 5Schematic representation of RHBDF1-promoted destruction of mammary epithelial cell apicobasal polarity and cell-cell connections Schematic representation of RHBDF1-promoted destruction of mammary epithelial cell apicobasal polarity and cell-cell connections Additionally, our data indicate that RHBDF1 overexpressi...

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PMC11754291

Differential Effects of UVA and Blue Light on Keratinocyte Morphology and Cytotoxicity We observed a distinct difference between the effects of UVA and blue light (Figure 7), which highlighted the boundary between non-ionizing and ionizing radiation.

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PMC11591794

Ou et al. explained the ability of GA to induce G2/M arrest by changes in cell cycle regulators in the human bladder transitional carcinoma cell line .

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PMC11314247

In this study, apoptosis was determined via flow cytometry using the FITC Annexin V Apoptosis Detection Kit (Roche Molecular Biochemicals, Basel, Switzerland) for a short and a long time based on Mawatari et al.’s work, in which they determined that VPA initiates histone acetylation and apoptosis before 6 h of treatmen...

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PMC10993311

Another study that sought to identify the methylation profile in DNAm datasets obtained from the GEO database in obesity found methylation-regulated differentially expressed genes, which are involved in the molecular function of fatty acids (Duarte et al., 2023), as highlighted in this study.

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PMC5810978

Caco-2 cells have been widely used for HuNoV culture trials and most research groups including our group could not grow HuNoV previously [31, 47–49].

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PMC8584319

Thus, our results suggest that ERK and p38 are closely related to the translation machinery through the regulation of 4E-BP1 mRNA expression.

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PMC9429973

Image: Summary/Conclusion: Among all factors studied we found that refractory anemia, unfavourable karyotype and higher risk group according to DIPSS scoring are the most important factors affecting the disease progression and overall survival with statistically significant difference.

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PMC11740907

The cells were treated with a 0.4% w/v solution of SRB dye for a duration of 30 min.

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PMC6034753

Immunoprecipitation was then carried out using DF-1 cells co-transfected with Meq and N-terminal tagged FLAG-Apoptin.

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PMC11088135

p < 0.01 vs. control-siRNA; p < 0.01 vs. inhibitor control; p < 0.01 vs. NUTM2A-AS1-siRNA + inhibitor control Next, we analyzed the effects of lncRNA NUTM2A-AS1 on the proliferation and apoptosis of U251 cells by loss-function experiments.

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PMC7171147

The Seahorse XF FAO assay and the XF glycolysis stress assay were performed using a Seahorse XFp analyzer (Agilent) according to the manufacturer’s protocols.

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PMC4369959

However, they found a significant decrease in PGE2 and 5-hydroxyeicosatetraenoic acid (HETE) and a trend toward significant decrease in 12-HETE and 15-HETE normalized to free arachidonic acid .

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PMC11594074

The 3D structures of the ligands were downloaded from the ZINC15 database (https://zinc15.docking.org, accessed on 27 November 2022), and the crystal structure of DNMT1 was downloaded from the Protein Data Bank (https://www.rcsb.org, accessed on 9 February 2023) (PDB code 4WXX).

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PMC11291490

It is generally recognized that IFNγ dependent Th1, besides neutralizing antibodies, responses are necessary to prevent Flavivirus infection.

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PMC11541409

: p. e1881.This reference is of importance because clearly demonstrates that ALK mutation is one of the oncogenes that contribute to the drug resistance of wild-type GIST in the clinical setting.

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PMC4355729

In our study, the expression of NCAD, VIM and ZEB1 was elated in the cells with the downregulation of PIK3R1, whereas the expression of ECAD was decreased in these cells.

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PMC4112127

We aimed to quantitatively assess BMP3 methylation in resected CC tumor specimens using methylation specific PCR and evaluate the tumor suppressor role of BMP3 in biliary cancer cell lines in comparison to an immortalized normal cholangiocyte cell line.

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PMC9429973

Combination of CD20-TCB with a CD19-4-1BBL fusion protein (tumor-targeted co-stimulatory drug) resulted in enhanced CLL cell killing in both T:CLL and triple T:CLL-EC culture assays.

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PMC11656380

100% LDH leakage was determined in 0.2% (w/v) Tween 20.

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PMC7452526

It could be adsorbed on the surface of AgNPs enabling their reduction from Ag and preventing them from agglomeration .

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PMC10698968

Also in this case, NCC-MFS1-C1 cell line has a more resistant phenotype to this drug than that of MF-R 3 to doxorubicin and epirubicin.

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PMC11734514

Figure 3Jak/Stat Signaling Protein expression (PTEN, AKT, p-AKT, p-mTOR, and STAT-3) in A549 cells treated with C. aerizusa. (

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PMC10847511

Platinum agents (shown in the top panel) and PARP inhibitors (shown in the second panel) exhibiting a trend for positive or negative differences (unadjusted P < 0.05) between the two groups are highlighted in red and blue font, respectively, and those remained statistically significant (adjusted P < 0.05) after multipl...

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PMC11727145

The evaluation of different stages of burn wound exudation could be performed to further develop the DED model as a functional testing platform for cutaneous cellular therapies and different combinations of physiological skin cell types.

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PMC11257203

Briefly, tris buffer was added to 1 mL of each homogenate sample (treated lymphocytes/mice bone marrow) and vortexed for 1 min.

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PMC2614416

Gene ontology (Michael Ashburner ) analyses are carried out with Blast2GO ; a java webstart-enabled Gene Ontology annotation, visualization and analysis program.

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PMC11585994

We then investigated the potential anti-leukemia effect of nanoparticle formulation in T-ALL PDX mouse model (Figure 4A).

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PMC11659921

Additionally, we assessed the distribution proportions of various CNV categories—heterozygous amplification, heterozygous deletion, homozygous amplification, and homozygous deletion—among angiogenesis‐ and stemness‐related genes in OV patients (Figure 2C).

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PMC4355729

The fragments were determined by Sanger sequencing.

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PMC10761571

Based on this study, Fe3O4@Glu-Gingerol remarkably promoted the expression of the proapoptotic genes, CASP8 and BAX.

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PMC11759543

Symbols ∗ and # were compared with control and Z- LEHD-FMK only, respectively.

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PMC9429973

15 thrombotic events (14 hospital control vs 1 in remote control).

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PMC9429973

We found no association with age, sex, central nervous system infiltration, or leukocyte count.

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PMC11349530

In particular, not only VEGF affects angiogenesis, but also many of the other factors are capable of angiogenesis upregulation [for instance, IL-6 (38), TNF (39), IL-33 (40), MCP-1/CCL2 (41), IL-8/CXCL10 (42), kynurenine (43), adenosine (44)].

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PMC11488203

In certain neoplastic developments miRs can be dysregulated.

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PMC11650848

Increases in beta band power can be seen when physical movement is successfully cancelled, while planning movements or executing movements decreases beta power in the brain .

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PMC10523483

Verification of H1.2 knockout in A549 cells. (

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PMC9917080

Increased expression of glutathione reductases and thioredoxin peroxidases after exposure to SeNPs and SeSo can be considered an activation of the antioxidant systems of astrocytes in the cerebral cortex.

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PMC11025866

Since xCT is overexpressed in a number of malignancies, inhibition of xCT is one therapeutic strategy for treatment of these cancers .

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PMC7192625

Comparison of PCHi-C and Hi-C networks. (

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PMC11730320

The variant removes the core promoter, the transcription start site, the translation start site and subsequent protein sequence encoded by the first exon of PTCRA, thus very likely resulting in complete loss-of-function (Fig. 2A).

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PMC9895440

Controls without T cells (maximal signal) and one with 0.1% Triton-X100 (minimal signal) were used to calculate % specific lysis:[12pt] $$\%\,\,=(1-(-\,}\,-\,})) 100\%$$%specificlysis=1−signal−minimalsignalmaixmalsignal−minimalsignal×100% To measure proliferation and stability after repetitive stimulation, cells on day...

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PMC9878562

In many solid cancers altered expression levels of ACKR3 correlate with poor prognosis and tumor metastasis (22–29).

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PMC11422497

Despite this, the availability of effective tumor biomarkers for GISTs diagnosis and prognostication remains limited.

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PMC9429973

Of note, PTK2B was highly expressed in leukemic stem cells (LSCs) from FLT3-ITD mutated patients.

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PMC11188874

After 12 hours, cells were washed with FACS buffer twice and stained with annexin-V conjugated with FITC and anti-CD8 conjugated with APC (BD Biosciences, BDB553035).

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PMC11676670

The main genetic characteristics of HGSOC include TP53 mutations, homologous recombination deficiency, and a high level of genomic alterations .

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PMC11718109

We now demonstrate that DA nerve terminals show three pools of secretory vesicles: SSVs, large empty vesicles and DCVs in iPSC-derived DA neurons and synaptosomes from DA nerve terminals of mouse striata.

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