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PMC11767817
Due to these activities, curcumin has been considered a potential therapeutic agent for treating several diseases, including cancer and metabolic, cardiovascular, pulmonary, neurologic, and autoimmune diseases .
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PMC6461034
Visually check equal distribution of the beads to the “IP” tubes and store on ice.
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PMC6901583
p65 knockdown using siRNA abolished the induction of CCL2 in GIST-882 cells (Fig. 6b).
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PMC10734950
Cells were incubated for 4 h with CC50 (obtained after 24 h of incubation), and two times (2X) the CC50 (2.89 μM and 5.78 μM), and the integrity of the mitochondria was assessed.
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PMC11806106
Fragment 2 rev and vector+mTurq fwd same as M264 short.
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PMC11768927
A key determinant of VSV’s oncolytic efficacy lies in its ability to exploit the defective type-I IFN signaling pathways commonly found in cancer cells, enabling selective viral replication and lysis of infected cells.
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PMC11443022
Some reports indicate that 90% of cases diagnosed prenatally have a normal male phenotype, whereas those diagnosed postnatally exhibit a wide range of phenotypes.
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PMC11025866
VPA and VPM were dissolved in DMSO.
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PMC11237030
Methods to perform biopanning on soluble purified proteins are well established.
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PMC11448304
Total RNA was extracted using the Total RNA Extractor (Trizol) kit (B511311, Sangon, China).
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PMC9429973
Methods: We retrospectively reviewed FISH, CMA and Q30 data for new AML cases diagnosed in the specialist integrated haematological malignancy diagnostic service (SIHMDS) at University College London Hospital over a 2 year period: 01 Jan 19 to 31 Dec 20.
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PMC11538390
Here we conducted a GWAS in the Finnish population and report a novel association between isolated CP and the IRF6 gene locus.
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PMC11530949
A significant increase in the expression of Bax, Caspase3, and P53 genes was observed at the IC50 concentration, with approximately a 2.5 and 4-fold increase for the extract and the Ag-doped CuO NPs, respectively.
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PMC9844987
Distribution of single cell adjusted variability [log10(CV)] of genes for low variable promoters (blue) and highly variable promoters (red). (
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PMC11666785
The background noise mentioned here is basically the noise present in the raw data, the origin of which could be fluorescence background noise, electronic noise, thermal noise, and other noises that give rise to false detections.
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PMC11720107
In the CACO-2 cell line, the Ornak garlic cultivar significantly increased ROS production at concentrations of 0.062, 0.125, 0.250, 0.500, and 1.000 mg/mL by 302.4%, 343.5%, 677.6%, 666.3%, and 1393.4%, respectively, compared with the control group (Figure 1F).
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PMC11703896
This could also facilitate in understanding the possible action mechanisms of rapamycin in other diseases such as neurovegetative diseases, autoimmune diseases, etc.
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PMC11765243
This fosters the effect of p110δ and DNA protein kinase inhibitors, with wide differences in sensitivity to inhibition depending on the nature of the cells (i.e., naïve, blasts) and the cytokine considered .
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PMC9429973
Ten of the 17 patients had next generation sequencing performed.
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PMC11026382
To prevent re-circularization, the digested plasmid was treated with Antarctic phosphatase for 1 h at 37 °C.
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PMC9370419
The N-terminal fragment of HBx remains insoluble, and the C-terminal portion adopts several α-helices.
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PMC11655536
Percentages of apoptotic cells of RPMI-8226 and U266 were calculated from three independent experiments.
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PMC11388384
To understand whether SHH was capable of extracellular diffusion, we first asked whether cytonemes on SHH-producing (“sender”) cells are required to deliver SHH from sender cells to responding (“receiver”) cells.
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PMC8633974
Next generation sequencing will be employed in future studies to validate the accuracy of these findings.
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PMC6742971
Traditionally, generating or selecting high avidity TILs in vitro include MHC/antigen tetramer staining and sorting, with stronger tetramer binding indicative of higher avidity and tumor reactivity (8, 18).
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PMC11752767
The effectiveness of CAR-T-cell therapy depends on the design of CAR proteins, which typically consist of three components: an extracellular domain that binds to tumor antigens, a transmembrane domain for structural stability, and an intracellular domain for signal transduction.
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PMC10565698
D and E. After overexpression of miR-211-5p in HCCLM3 and BEL-7407 cells, TCF12 and CREB5 expression was analyzed by qRT-PCR.
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PMC6643347
Inhibition of viral replication in TZM-bl, PBMC, Mϕ, and DCs infected with HIV-1SF162, HIV-1QH0, and HIV-1Ba-L R values were calculated for IC50.
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PMC10605143
These differences in the expression levels of EMT markers are reflected in cell morphology.
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PMC11786767
The sample sizes “N” and “n” indicate the number of examined cells and chromosomes, respectively.
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PMC11306019
Therefore, MAC cannot be used to compare our results (6.25 nM and lower concentration of BTZ were used in our study) with data from previous papers.
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PMC11607321
These challenges could be associated with the inherent limitations of SHAP and Shapley values, thus additional research is required to ascertain the importance of these emphasized features.
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PMC11680049
In all variations, proliferation of callus cells was observed at the sites of cuts and injuries.
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PMC11552389
Significantly more autophagosomes were evident in drug-resistant cells as compared to drug-sensitive cells.
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PMC11300085
However, the different doses of chemerin treatment had no significant effect on the proliferation of OVCAR-3 cells at 24 and 48 h. Only higher concentration of chemerin (100 ng/mL) had an inhibitory role in cell growth at 72 h (Figure 1(b)).
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PMC9878562
8–10-week-old mice were injected subcutaneously with 10 VAL or DOHH2 cells in PBS, or only PBS for control groups.
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PMC11528603
This anticancer activity was the combination of apoptosis activation (intrinsic apoptosis via Apaf-1 independent manner) and antiproliferation (CDKN1A upregulation and PCNA downregulation).
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PMC4816271
We have generated a GD2 CAR targeting retroviral cassette optimized for efficacy and safety.
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PMC5941560
In addition, a multicolor-Fluorescence In Situ Hybridization study from 2013 found within-culture mosaicism on a tetraploid background .
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PMC11607638
SKR transcript was detected at all developmental stages of A. aegypti (Figure 1D).
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PMC11528603
This study, therefore, aimed to elucidate the effects of S. affinis fruit extracts, namely, SA-EtOH, SA-PE, SA-EA, and SA-H2O on promyelocytic leukemia HL60 cell line.
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PMC11055323
To test this hypothesis, we focused on H3K27ac and show that H3K27ac distribution is dramatically different between SS18 to SS18-SSX (Fig. 4a, b), with significant enrichments in the onco-condensates, which has not been observed from the other common active epigenetic modifications, such as H3K9ac, H3K4me3, and H3K36me...
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PMC11769516
Mitochondria also convert about 5% of oxygen in cells into ROS.
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PMC11055323
Scale bars, 5 μm.
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PMC9429973
Forty five patients received anthracyclines in a total dose of anthracyclines <360mg / m2 and no-one was irradiated.
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PMC11412721
Allele 4.14a encodes a putative protein with 59 N-terminal residues of ACKR4 and 34 amino acids of unrelated sequence due to the mutational frameshift.
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PMC7917457
Ad5/3-D24 has been previously described.
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PMC11790971
However, the performance-based cell line selection in the early stages of development can be problematic because culture conditions are usually different from those in large-scale production, potentially leading to the exclusion of promising candidates or the selection of poor producers.
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PMC11596967
The cells were cultured in RPMI-1640 medium (Gibco, Waltham, MA, USA) with 10% fetal bovine serum (FBS, Biowest, Riverside, MO, USA) and antibiotics (100 U/mL penicillin and 0.1 mg/mL streptomycin) at 37 °C in a 5% CO2 incubator.
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PMC11742047
Cell apoptosis and necrosis in HL-60 and K-562.
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PMC11641532
After the culture period, cells were fixed and stained to visualize and count colonies, defined as clusters containing at least 50 cells.
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PMC9429973
The progression towards haematological diseases seems to be correlated with the acquisition of molecular and cytogenetic abnormalities.
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PMC9429973
TTP pathophysiology is based on a severe ADAMTS13 deficiency, the specific von Willebrand factor (VWF)-cleaving protease.
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PMC11240448
The list of module outputs is presented in Supplementary Table S4.
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PMC2614416
Tan and co-workers examined an immortalized mouse retinal cell line (661W) for markers characteristic of photoreceptor cells; they found that the 661W cell line exhibited similar cellular and biochemical characteristics to those of the original cone photoreceptor cells from which they were derived.
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PMC11727000
According to our analysis using the STRING database, complexes including SPEN, SMARCE1, and the N-CoR complex have been observed previously in several studies, as reported in the BioGRID database.
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PMC11064533
However, ΔfimH exhibited no effect on adhesion and motility.
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PMC8481254
Scale bar, 500 μm.
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PMC11791432
In the CGGA325 cohort, ANXA1 also showed prognostic value in Glioma and LGG: Glioma (Fig. 4D n = 241, HR=1.509, P < 0.001), LGG (Fig. 4E n = 139, HR=1.462, P < 0.001).
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PMC11683240
The effect of α1AT on binding of PT to cells was investigated by using fluorescence-labeled PT in flow cytometry analysis.
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PMC11656657
A p value < 0.05 indicates a significant difference.
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PMC11036064
Besides, our results have indicated no statistically significant associations between the survival of primary GBM patients with hsa-miR-34a-5p expression level (P-value = 0.65) (Figure 5B(Fig.
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PMC10329074
However, no meaningful differences in survival were identified among the T1 (HR: 1.07; 95% CI: 0.61–1.89; P = 0.813), T3 (HR: 1.36; 95% CI: 0.90–2.05; P = 0.141), T4 (HR: 1.87; 95% CI: 0.43–8.09; P = 0.402), M1 (HR: 0.87; 95% CI: 0.53–1.43; P = 0.578) and N1 (HR: 0.69; 95% CI: 0.20–2.39; P = 0.561) subgroups of OS.Fig.
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PMC11209164
Qiagen, Toronto, ON, Canada, Cat.
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PMC11380329
Absorbance was measured in a microplate reader spectrophotometer at 560 nm.
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PMC11092382
Dioscoreaceae]), is a classic Chinese herbal formula with a clinical application history of more than 40 years, exhibits significant efficacy in treating hot syndrome-related rheumatoid arthritis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9817179
The knock-in A673 cell line was further authenticated using Short Tandem Repeat (STR) profiling (ATCC Cell Line Authentication Service) against the following loci: TH01, D5S818, D13S317, D7S820, D16S539, CSF1PO, Amelogenin, vWA, and TPOX.
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PMC11699465
TMEM199 modulates Tumor microenvironment (A) CCK8 assay to show the cell viabilities in 4T1 cells with TMEM199 knockdown or overexpression.
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PMC11694066
As the replication stress and R-loop dependency of this phenotype may also operate in other, more frequent, transcription factor–driven sarcomas, such as Ewing sarcoma or synovial sarcoma, we hope that this will favor the development of basket studies enrolling multiple biomarker-selected sarcomas and allow patients to...
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PMC11739484
With its user-friendly interface, GEPIA2 enables researchers to explore cancer-related data comprehensively, allowing comparisons of gene expression and survival durations between normal and tumor tissues using The Cancer Genome Atlas (TCGA) datasets.
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PMC11747949
CCR2 blockade increased the fraction of VEGFR, as well as PD‐L1 tumor cells, which might indicate an evasive mechanism when an alternative proangiogenic, immunosuppressive pathway is activated.
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PMC8073654
In a further mechanism study on the antiproliferative effect of 2 in A549 cells , trans-3-(3,4-dimethoxyphenyl)-4-[(E)-3,4-dimethoxystyryl]cyclohex-1-ene (11) induced G0/G1 phase cell cycle arrest by downregulating the expression of cyclin-dependent kinases (CDKs) and cyclins and by suppressing CDK activity via the ind...
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PMC9910796
Subcellular localization of pEP84R.
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PMC11122631
The COSY correlations of H-13/H-14, H2-16 (δH 2.38)/H2-17 (δH 1.59)/H2-18 (δH 1.29), H2-19 (δH 1.29)/H3-20 and the HMBC correlation from H-19 to C-18, from H-14/H-16 to C-15, and H-13 to C-12 were used to establish the connection of the ω-side chain and a ketone group located at C-15.
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PMC11365983
The majority of genes dysregulated in the Pdgf mutant are similarly up- or down-regulated in Foxc1 mutant embryos; a correlation that extends to 1193 of 1324 genes; correlation coefficient ρ = 0.77, P = 2.2 × 10. (
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PMC11695546
The cytotoxic impact of ozonized and crude oil on A-431 cells (cell type: epithelial; disease: epidermoid carcinoma) was detected by MTT procedure after the oil was dissolved in DMSO.
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PMC2944824
In cells treated with tunicamycin, the number of cells displaying fragmented nuclei was approximately two-fold higher in mock transfected cells compared to cells expressing Hr.
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PMC10898159
2Regulations in KIT protein and signaling pathway.
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PMC11549612
Furthermore, their enrichment in pathways related to cancer and signaling cascades underscores their potential significance in disease pathogenesis and cellular signaling networks.
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PMC11033180
After washings, the samples were incubated in PBS containing 10% BSA for 30 min to block non-specific sites and were then incubated overnight at RT with primary antibodies diluted in PBS containing 3% BSA and 0.01% sodium azide.
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PMC11543885
The first two types provide insights into the protein-protein interaction (PPI) network and local milieu of NLRP3.
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PMC11705484
Two‐tailed Student's t‐test was used for comparisons between the two groups.
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PMC3164356
10 μg/ml colchicines were added into 50–75% confluent cells in one 6-cm dish to obtain a final concentration of 0.05 μg/ml colchicine.
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PMC11802929
Densities for peptide groups were projected onto GEX-UMAP by matching the antigen specificity of each single CD8 T cell to the peptide group that antigen peptide belongs to.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11185260
N = 4–6/group.
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PMC9429973
Crossover from O+Clb to A occurred in 72 (41%) patients; 25% of these patients discontinued A (10% due to AEs and 11% due to progressive disease).
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PMC11075223
Shengma Biejia Decoction had good therapeutic effect on systemic lupus erythematosus of yin deficiency and internal heat type .
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PMC10994876
Supporting this theory, a study conducted on muscle satellite cells revealed that the constitutively active YAP leads to an upregulation of genes linked to the process of ribosome biogenesis and assembly (Judson et al. 2012).
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PMC9429973
FISH analysis was performed on unstimulated BM samples or on isolated plasma cells.
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PMC10976516
In one study, the extracellular enveloped virus (EEV) form of VV was covered by a lipid layer with anti-complement proteins after which systemic use of these modified EEVs generated a far lower viral clearance.
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PMC11388384
Whole explants were imaged using an inverted epifluorescence microscope with a 10× objective, then moved to a TIRF microscope for single-molecule imaging experiments.
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PMC10723784
The early apoptotic cells are stained with Annexin V‐CF488A, which fluoresces green.
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PMC10705095
Despite advances in diagnosis and treatment, the prognosis of lung cancer remains poor; thus, further research is necessary in order to improve patient outcomes, particularly in those with lung adenocarcinoma cases.
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PMC10944868
White solid: H NMR (CDCl3, 400 MHz): 0.94 (t, 3H, J(HH) = 7.4 Hz), 1.62–1.71 (m, 2H), 4.08 (t, 2H, 3J(HH) = 607 Hz), 5.53 (d, 1H, J(HH) = 12.6 Hz), 5.64 (s, 1H), 7.46–7.53 (m, 5H), 7.55 (d, 1H, J(HH) = 12.6 Hz).
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PMC5035325
into the mammary gland with 1 × 10 of tumor cells.
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PMC11615218
Another type of tonic signaling activation involves self-aggregation via the framework region of the single-chain variable fragment of CAR on CAR-T cells, which impairs proliferation and promotes exhaustion .
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PMC7553912
b–d) The number of CD45/F4/80/CD11b cells (total macrophages; b), CD45/F4/80/CD11b/Ly6C cells (M1 macrophages; c), and CD45/F4/80/CD11b/CD206 cells (M2 macrophages; d) in the kidney of WT and OSMRβ mice was evaluated by flow cytometric analysis.
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PMC11657744
It also localizes to the basal body and plays a key role in ciliary disassembly by stimulating HDAC6-dependent tubulin deacetylation .
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PMC10976516
Saito et al.Ad-uPAR-MMP-9, expressing antisense RNAs against uPAR and MMP-9Intratumoral and intravenousAd-uPAR-MMP-9 was injected into a subcutaneous xenotransplant lung tumor (H1299).
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PMC9920575
These results allow us to suggest that the S. chinantlense extract induces death by apoptosis in HeLa tumor cells in the same manner as the antineoplastic agent cisplatin.
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