OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11354239	Further studies have shown that combining an anti-CD20 antibody with Monalizumab, an antibody that efficiently releases the inhibition conferred by the engagement of the inhibitory receptor NKG2A on NK cells, enhances NK cell-mediated ADCC, emphasizing the importance of the activation status of NK cells in determining ...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878562	Lymphoma cell migration in 3D chemotaxis were performed using µ-Slide Chemotaxis (Ibidi).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lymphoma", "cell", "migration", "in", "3D", "chemotaxis", "were", ...
PMC10831439	Relapse and graft-versus-host disease (GVHD) are the main causes of death after allogeneic hematopoietic cell transplantation (HCT).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relapse", "and", ...
PMC9812014	EBOV possesses a single negative-strand RNA genome with a genomic size of 18,898 nucleotides.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EBOV", "possesses", "a", "single", "negative-strand", "RNA", "genome",...
PMC11746942	C EdU staining demonstrates that TY inhibits IL-6-induced HaCaT cells proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "C", "EdU", "staining", "demonstrates", "that", "TY", "inhibits", "IL-6-induced", "...
PMC9503685	According to the results of the study, ceragenins have advantages in terms of antimicrobial effect as well as structural and productive advantages over AMPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11798926	All animal use was approved by the institutional animal care and use committee at the University of California, Davis, in accord with the guidelines laid out by the US Public Health Service.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5363531	Further investigation to establish the main TS promoter-responsive region and corresponding transcription factors involved in this regulation are clearly needed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "investigation", "...
PMC9429973	Therefore, this immune signature has a strong predictive value for clinical response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "this", "immune", "signature", "has", "a", "strong", ...
PMC11721587	PLA revealed that Gli2 formed a complex with Ulk3 and Sufu in the nucleus of intact cells (Fig. 6J).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PLA", "revealed", ...
PMC11394112	Membranes were probed with antibodies against TBP (ab818, Abcam; 1:2500), STAT3 (79D7, Cell Signaling Technology, Danvers, MA, USA; 1:2000), and p-STAT3 (Tyr705, Cell Signaling Technology; 1:1000).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706491	Gene deletions were performed using a polymerase chain reaction (PCR)-based method and were confirmed by PCR on genomic DNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Gene", "deletions", "were", "perf...
PMC9611901	With this experimental model, we also cannot predict the extent to which potentially harmful chemicals will penetrate into the deeper layers of the skin and potentially cause significant toxic effects there.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9985266	Subsequently, 10 μL of Protein A agarose/SaLmon sperm DNA was added to the lysate and incubated for 2 h to precipitate the protein‒DNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10577955	Cyclin D1 is a necessary protein for the cell cycle to continue through the G1 phase, where its over-expression has been linked to early cancer onset and tumor development and could promote oncogenesis by boosting anchorage-independent growth and angiogenesis via VEGF production .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10965315	Hence, in this investigation, we have explored the anticancer properties of harmaline on A2780 OC cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Hence", ",", "in", "this", "i...
PMC10674574	Therefore, the development of intra-laboratory protocols for the cultivation and differentiation of Caco-2 cells is necessary to provide consistently cultivated functional cell monolayers and reduce in-house variability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770746	Sensitivity to cold was recorded by the duration of nocifensive responses such as brisk withdrawal, flick of the paw, repeated flicking of the paw, repeated flicking of the hind paw, and licking of the paw.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10926885	In addition, the results of in vitro experiments demonstrated that the knockdown of NDE1 not only resulted in reduced proliferation, invasion and migration of bladder cancer cells, but also promoted apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3164356	CHO cells lack the sufficient enzymatic machinery to produce glycan structures with the α-Gal epitopes, except in very small subpopulations.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CHO", "cells",...
PMC10197932	Furthermore, a remarkable NK Granzyme B expression (upper left quadrants on density plot stimulated cells by CD3/CD28) is also visible after ultrasound treatment demonstrating indirectly that the innate immune cells system isn't compromised at all by US treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6461034	Interestingly, in a pancreatic cancer patient, no residual EGFR activity could be inferred by INKA in a tumor biopsy after erlotinib treatment (Fig 5D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11052306	Only dendrimer 6c-G1 was relatively active at a concentration of 10 M, but it was more toxic against the non-cancerous cells RPE1 (Figure 10) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...
PMC11402217	Initial TUNEL assays demonstrated that high-dose XD23 markedly induced apoptosis in OS cells in tumor OS cells, with effectiveness similar to lower doses of MTX (Figures 6B and 6C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11462673	F. RT-PCR analysis showed a significant reduction in the expression of MYB, ERG, ETS1, and ETV6.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F.", "RT-PCR", "analysis", "showe...
PMC8740518	Highest confidence interval.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Highest", "confidence", "interval", "." ] } ]
PMC10253973	Compound TLD1433 (21) has passed the second stage of clinical trials on the non-invasive treatment of the urinary bladder with photodynamic therapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11531744	However, the immune system seemed to play a role in ovarian cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "immune", "system", "seemed", "to", "play", "a"...
PMC11779876	Bubble plots were generated using pandas (v2.1.4), NumPy (v1.26.4) and matplotlib (v3.8.0).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bubble", "plots", "were", "genera...
PMC8343815	Nanoparticles were incubated with HeLa cells, as described in the previous section.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nanoparticles", "were", "incubated", "with", "HeLa", "cells", ",", "as", ...
PMC10213199	Further analysis of the co-expression map (Fig. 4) identified the top 10 key genes, as follows: regulatory particle non-ATPase (RPN), regulatory particle triple-A ATPase (RPT), and tripeptidyl-peptidase II (TPP II) (Fig. 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11711663	The rationale behind this approach is that imaging captures crucial information about tumor phenotype and microenvironment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "rationale", "behind", "this", "approach", "is",...
PMC9118379	Of the 320 spectra, the top 10 hits of 89, 95, and 97 spectra obtained from PepNovo+, pNovo+, and PEAKS (green bar), respectively, contained the corresponding variant peptides (Figure 5A), of which more than 79.8% belonged to rank-1 or -2 hits from the three tools (Figure S6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11506827	Compounds such as kahweol acetate, honokiol, englerin A, and epigallocatechin-3-gallate have shown diverse anti-cancer properties in RCC .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compounds", "such", "as", ...
PMC10605143	Finally, read counts were normalized using DESeq2 (v. 1.32.0) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "read", "counts", "were", "normalized", "using", "DESeq2", "(", ...
PMC9429973	Arne Van der Vreken and Inge Oudaert contributed equally to this work.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Arne", "Van", "der", "Vreken", "and", "Inge", "Oudaert", "contributed", "equally...
PMC9429973	A bone marrow exam is performed on day 21±3 of 1 cycle and ven is held if blasts <5% to allow count recovery.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Genomic risk features (Table) were also assessed at baseline.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Genomic", "risk", "features", "(", "Table", ")", "were", "also", "assessed", "at", ...
PMC11615101	The rats were acclimatized for 2 weeks and fed a standard rodent chow diet and water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "rats", "were", "acclimatized", "for", "2", ...
PMC9545714	In addition, in essential fatty acid deficiency, oleate replaces linoleate in the acylceramide and TEWL increases to at least fivefold.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "additi...
PMC11767582	The organic phase was dried over anhydrous Na2SO4, and the mixture was concentrated to dryness and purified by flash column chromatography on silica gel using mixtures of n-hexane and ethyl acetate as eluents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754094	We further investigated subsequent pathways leading to large deletions mediated by the BEs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "further", "investigated", "subsequent", "pathways", "leading", "to", ...
PMC9429973	Image: Summary/Conclusion: Pts who completed 6 Tx cycles with FEDR 400 mg/d, whether used as 1L MF Tx or after RUX Tx, experienced substantial improvements in spleen volume and MF symptom severity regardless of the extent of splenomegaly at BL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11314247	The results at 48 h show that DMSO maintained ≅ 95.3% of living cells, whereas chelerythrine showed apoptotic effects (Figure 2, Figure 3 and Figure 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11247842	As individual-level WGS data for the mapping populations were not available, we checked the LD of the CNV tag SNPs from Lee et al. with the CNV we found in the Nordic Holstein animals (Table 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10589262	As previously established by multiple studies, including ours, we confirmed that MT-KIT initiates downstream signaling in the Golgi complex.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "previously", ...
PMC9596868	Values represent mean ± SD of three technical replicates analysed by ANOVA with Dunnett's Multiple Comparison test. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Values", "represent", "mean", "±"...
PMC4360730	This process involves reviewing protocols, reagent vendor materials and primary literature to provide additional detail and verification for metadata of each category.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...
PMC11047729	A study on the monocytic leukemia cells U937, SHI 1, and THP-1 showed Tan I-induced apoptosis through the activation of the caspase-3 pathway and slowed cell growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "I-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11699042	on R version 4.2.1.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "on", "R", "version", "4.2.1", "." ] } ]
PMC11323699	Additionally, contradictory results have suggested that patients with advanced OC with high TSP-1 staining may experience improved survival .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "contradictory", ...
PMC11750712	Anti-CD7 CAR T have been tested in T cell acute lymphoblastic leukemia, with high response rates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Anti-CD7", "CAR", "T", "have", "been", "tes...
PMC11683240	The number of replicates (n) for experiments or tested conditions is given in the figure legends.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "number", "of", "replicates", "(...
PMC9031474	The generation of ROS is not restricted to IR and can also result from endogenous (e.g., mitochondria) and exogenous sources (e.g., heavy metals, xenobiotics) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11122631	There are two key roles for pharmacokinetics: P-glycoprotein and cytochrome P450 (CYP) enzymes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "are", "two", "key", "roles", "for", "ph...
PMC3888431	De novo transcriptome assemblers produce a large number of misassembled or incomplete transcripts .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "De", "novo", "transcriptome", "assemblers", "produce", "a", "large", "numbe...
PMC9512971	Overall, these findings highlight the continuing need to identify and develop alternative therapies for COVID-19 and the necessity of conducting well-designed studies to confirm whether preclinical findings translate into meaningful clinical efficacy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11779993	cDNA was synthesized using SuperScript VILO™ cDNA synthesis kit (Thermo Fisher Scientific, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "cDNA", "was", "synthesized", "using", "SuperScrip...
PMC11545737	There is well-established evidence that pyroptosis is often useful in controlling infections.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "is", "well-established", "evidence", "that", "pyroptosis", "is", "often", ...
PMC10578720	Specifically, succinate exerts its proinflammatory actions through many mechanisms, including stabilizing HIF-1α, affecting mitochondrial ROS production, and activating cell surface receptor, the G-protein–coupled receptor succinate receptor 1 in macrophages.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11474209	When ATM is autophosphorylated at Serine 1981 residue, the following signaling molecules in the cascade are activated, thereby repairing the damage.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", ...
PMC11696576	As an energy source, FAO produces high levels of mitochondrial ROS, which can trigger programmed cell death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "an", "energy", "source", ...
PMC11739504	The graph in Fig. 1d was generated from the results of three independent experiments under the identical conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "graph", "in", "Fig.", "1d", ...
PMC9622879	As the local buying/selling prices are better than the buying/selling prices proposed by the EP, this cost of each home in the community with the prosumer-centric CEMS and proposed CEMS is always better than that of each home in the community with no CEMS, where every home must directly trade its surplus energy with th...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792888	However, some therapeutic properties are usually limited and accompanied by unwanted collateral effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "some", "therapeutic", "properties", "are", "usually", ...
PMC11714165	The targeted nanoparticles efficiently inhibited tumor progression and osteosarcoma‐induced bone destruction in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "targeted", "nanoparticles", "efficiently", "inhibited", "tumor", "progress...
PMC10421378	Samples were measured after 1, 2, 3, 6, 9 and 12 months of storage or until the point at which their viability decreased below the 10 cfu/g threshold.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7351993	Third, without the molecular specificity provided by these labeling methods, intracellular fluorescent staining with fluorescent dyes suffers from non-specific binding and low quantitative performance since it relies on the difference in their chemical affinity to target biomolecules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	There is growing evidence that treatment needs to be individualised and with the growing use of lifestyle monitoring devices such as smartwatches, this wealth of information could be utilised to determine transfusion need.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	At DL2, no SAE or dose limiting toxicity was reported up to the date of data cut off.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "DL2", ",", "no", "SAE...
PMC7171147	To determine whether high levels of FAO genes are associated with poor prognosis, we correlated the expression levels of FAO genes (CPT1A, ACAA2, and HADHA) with overall survival in high-grade serous ovarian cancer patients using the Kaplan–Meier plotter (https://kmplot.com).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	The PDMS mixture was composed of PDMS A:cross-linker B at a ratio of 1:10 (wt/wt).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "PDMS", "mixture", "was", ...
PMC11736898	Responses to treatment were dominated by the relatively strong effects of vitamin D on induction of CAMP expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Responses", "to", "treatment", "were", ...
PMC11082662	In contrast, the proposed SMPDL3B gene has the potential to serve as a new prognostic marker for diagnosing ovarian cancer, offering promise for enhancing the efficacy of diagnosis and treatment in women afflicted by this challenging disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11352666	Venetoclax is a BCL-2-selective small-molecule inhibitor that is FDA-approved in combination with other agents for the treatment of adults with chronic lymphocytic leukemia, small lymphocytic lymphoma, or AML .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Among the non-hematological adverse effects, the most common grade 3-4 adverse effects were nausea and vomiting (38.7%), fatigue (18.6%), and infection (18.6%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7553912	a,b) Gene expression of OSM (a) and OSMRβ (b) in the kidney on days 0 (without GOx injection), 3, 6, or 9. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11295144	They belong to a diverse family of GABA-gated Cl/HCO3 permeable ion channels that promote neuronal differentiation and synaptogenesis in the developing brain by increasing neuronal excitability (Owens and Kriegstein, 2002; Raimondo et al., 2017; Cherubini and Ben-Ari, 2023).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10914904	Notably, in UV-B-exposed keratinocytes lacking vtRNA 2-1, PKR phosphorylation is triggered, resulting in increased NF-κB activity and increased expression of the proinflammatory cytokines TNF-α, MMP-9, and COX-2, thus exacerbating inflammation and accelerating skin aging .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8389560	Background fluorescence was subtracted frame by frame using the Math Subtract plugin in ImageJ. Calcium responses were shown as a ratio of Fura-2 fluorescence intensities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11473843	For the RNA sequencing, total RNA was extracted using a PureLink™ RNA Kit (Invitrogen, 12183018A), including an on-column DNase treatment (Invitrogen, 12185-010) according to the manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11759543	In the apoptosis pathway, caspase 8-caspase 3 cascade plays a significant part and might exhibit other signal(s) to the activation of caspases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10470467	Validation of mRNA expression of 3 key genes in cell lines. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Validation", "of", "mRNA", "expression", "of", "3", "key", "genes", "in", ...
PMC11365983	The prevalence of high and low Gli2-mGFP signal intensity in 7 independent experiments is also significantly altered compared to control [high Gli2-mGFP signal intensity ≥ upper quartile, green bar; low ≤ lower quartile of control, blue]. [	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	h qRT-PCR analysis for the expression of genes in human neutrophils associated with intracellular copper (MT1X), migration (S100A8) and pro-inflammatory activation (ISG15) obtained after 30 min incubation in conditioned media as per (e).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612508	Finally, the size distribution and average sizes of the NPs were analyzed using dynamic light scattering (DLS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "the", ...
PMC9429973	Image: Summary/Conclusion: Our study suggests that an altered pro-inflammatory anti-viral cytokine response pattern in children with E/R-BCP-ALL is specific to those children, who later developed the BCP-ALL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11611077	For electrophysiological experiments, statistical analyses were performed using one-way ANOVA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "electrophysiological", "experiments", ",", "statistical", "analyses", "were", "performed",...
PMC11756907	It was assumed that the reference system would be a 2-ME solution (0.5 mg/1 mL) appropriately diluted from the initial concentration of 2-ME obtained during the formation of the complex.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6379402	According to the gene expression data of cancer patients from TCGA, expression value of NUDT8 allows for stratifying cancer patients into subgroups having statistically significantly different survival curves (i.e., having different clinical outcomes) for eight cancer types: lung (log-rank p value = 4.12 × 10), liver (...	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767817	Compound 2a significantly increased SOD2, PON3, SIRT2, thioredoxin-1, p27, HIF-1α, FABP-1, and DKK-4 expression in 5637 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "token...
PMC11409031	We identified substantial disparities in the levels of diverse immune cell subcategories infiltrating tumors in high-risk versus low-risk cohorts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "identified", "substantial", ...
PMC11049294	Using the results of the AGAL activity measurement set on wild-type Jurkat cells, we examined the enzyme activity of GLA KO cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC6600592	The docking software MOE 2008.10 was used for molecular docking of oxime derivatives and a protein residue in HLA-A2.1-restricted CTL epitope (PDB ID: 3OX8) was selected for docking study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The annual rate of VOC experienced by the patient and leading to a healthcare visit within the preceding 12-months prior to crizanlizumab initiation and 12-month after will be assessed and compared as the primary outcome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11470999	In animal models, PF effectively inhibited melanoma growth and metastasis to the lung and brain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "animal", "models", ",", "PF", "effectively", ...
PMC9429973	After multivariate analysis for age, aetiology and LDH>ULN, ≥5 HLH-2004 (HR 4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "multivariate", "analysis", "for", "age",...
PMC8777939	With this approach, the overall five-year survival rate for ovarian cancer is approximately 46%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "this", "approach", ",", "the", "overall", ...
PMC9919300	Preclinical studies of curcumin indicate that it could be used for the treatment of hepatobiliary diseases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Preclinical", "studies", "of", "curcumin", "indicate", ...
PMC9454178	Cell viability was assessed with the CCK-8 assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "viability", "was", "assessed", "with", "the", "CCK-8", "assay", "." ] } ]

PMC11354239

Further studies have shown that combining an anti-CD20 antibody with Monalizumab, an antibody that efficiently releases the inhibition conferred by the engagement of the inhibitory receptor NKG2A on NK cells, enhances NK cell-mediated ADCC, emphasizing the importance of the activation status of NK cells in determining ...

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9878562

Lymphoma cell migration in 3D chemotaxis were performed using µ-Slide Chemotaxis (Ibidi).

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PMC10831439

Relapse and graft-versus-host disease (GVHD) are the main causes of death after allogeneic hematopoietic cell transplantation (HCT).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relapse", "and", ...

PMC9812014

EBOV possesses a single negative-strand RNA genome with a genomic size of 18,898 nucleotides.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EBOV", "possesses", "a", "single", "negative-strand", "RNA", "genome",...

PMC11746942

C EdU staining demonstrates that TY inhibits IL-6-induced HaCaT cells proliferation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "C", "EdU", "staining", "demonstrates", "that", "TY", "inhibits", "IL-6-induced", "...

PMC9503685

According to the results of the study, ceragenins have advantages in terms of antimicrobial effect as well as structural and productive advantages over AMPs.

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PMC11798926

All animal use was approved by the institutional animal care and use committee at the University of California, Davis, in accord with the guidelines laid out by the US Public Health Service.

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PMC5363531

Further investigation to establish the main TS promoter-responsive region and corresponding transcription factors involved in this regulation are clearly needed.

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PMC9429973

Therefore, this immune signature has a strong predictive value for clinical response.

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PMC11721587

PLA revealed that Gli2 formed a complex with Ulk3 and Sufu in the nucleus of intact cells (Fig. 6J).

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PMC11394112

Membranes were probed with antibodies against TBP (ab818, Abcam; 1:2500), STAT3 (79D7, Cell Signaling Technology, Danvers, MA, USA; 1:2000), and p-STAT3 (Tyr705, Cell Signaling Technology; 1:1000).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11706491

Gene deletions were performed using a polymerase chain reaction (PCR)-based method and were confirmed by PCR on genomic DNA.

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PMC9611901

With this experimental model, we also cannot predict the extent to which potentially harmful chemicals will penetrate into the deeper layers of the skin and potentially cause significant toxic effects there.

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PMC9985266

Subsequently, 10 μL of Protein A agarose/SaLmon sperm DNA was added to the lysate and incubated for 2 h to precipitate the protein‒DNA.

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PMC10577955

Cyclin D1 is a necessary protein for the cell cycle to continue through the G1 phase, where its over-expression has been linked to early cancer onset and tumor development and could promote oncogenesis by boosting anchorage-independent growth and angiogenesis via VEGF production .

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PMC10965315

Hence, in this investigation, we have explored the anticancer properties of harmaline on A2780 OC cells.

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PMC10674574

Therefore, the development of intra-laboratory protocols for the cultivation and differentiation of Caco-2 cells is necessary to provide consistently cultivated functional cell monolayers and reduce in-house variability.

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PMC11770746

Sensitivity to cold was recorded by the duration of nocifensive responses such as brisk withdrawal, flick of the paw, repeated flicking of the paw, repeated flicking of the hind paw, and licking of the paw.

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PMC10926885

In addition, the results of in vitro experiments demonstrated that the knockdown of NDE1 not only resulted in reduced proliferation, invasion and migration of bladder cancer cells, but also promoted apoptosis.

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PMC3164356

CHO cells lack the sufficient enzymatic machinery to produce glycan structures with the α-Gal epitopes, except in very small subpopulations.

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PMC10197932

Furthermore, a remarkable NK Granzyme B expression (upper left quadrants on density plot stimulated cells by CD3/CD28) is also visible after ultrasound treatment demonstrating indirectly that the innate immune cells system isn't compromised at all by US treatments.

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PMC6461034

Interestingly, in a pancreatic cancer patient, no residual EGFR activity could be inferred by INKA in a tumor biopsy after erlotinib treatment (Fig 5D).

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PMC11052306

Only dendrimer 6c-G1 was relatively active at a concentration of 10 M, but it was more toxic against the non-cancerous cells RPE1 (Figure 10) .

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PMC11402217

Initial TUNEL assays demonstrated that high-dose XD23 markedly induced apoptosis in OS cells in tumor OS cells, with effectiveness similar to lower doses of MTX (Figures 6B and 6C).

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PMC11462673

F. RT-PCR analysis showed a significant reduction in the expression of MYB, ERG, ETS1, and ETV6.

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PMC8740518

Highest confidence interval.

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PMC10253973

Compound TLD1433 (21) has passed the second stage of clinical trials on the non-invasive treatment of the urinary bladder with photodynamic therapy .

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PMC11531744

However, the immune system seemed to play a role in ovarian cancer.

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PMC11779876

Bubble plots were generated using pandas (v2.1.4), NumPy (v1.26.4) and matplotlib (v3.8.0).

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PMC8343815

Nanoparticles were incubated with HeLa cells, as described in the previous section.

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PMC10213199

Further analysis of the co-expression map (Fig. 4) identified the top 10 key genes, as follows: regulatory particle non-ATPase (RPN), regulatory particle triple-A ATPase (RPT), and tripeptidyl-peptidase II (TPP II) (Fig. 5).

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PMC11711663

The rationale behind this approach is that imaging captures crucial information about tumor phenotype and microenvironment.

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PMC9118379

Of the 320 spectra, the top 10 hits of 89, 95, and 97 spectra obtained from PepNovo+, pNovo+, and PEAKS (green bar), respectively, contained the corresponding variant peptides (Figure 5A), of which more than 79.8% belonged to rank-1 or -2 hits from the three tools (Figure S6).

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PMC11506827

Compounds such as kahweol acetate, honokiol, englerin A, and epigallocatechin-3-gallate have shown diverse anti-cancer properties in RCC .

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PMC10605143

Finally, read counts were normalized using DESeq2 (v. 1.32.0) .

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PMC9429973

Arne Van der Vreken and Inge Oudaert contributed equally to this work.

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PMC9429973

A bone marrow exam is performed on day 21±3 of 1 cycle and ven is held if blasts <5% to allow count recovery.

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PMC9429973

Genomic risk features (Table) were also assessed at baseline.

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PMC11615101

The rats were acclimatized for 2 weeks and fed a standard rodent chow diet and water.

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PMC9545714

In addition, in essential fatty acid deficiency, oleate replaces linoleate in the acylceramide and TEWL increases to at least fivefold.

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PMC11767582

The organic phase was dried over anhydrous Na2SO4, and the mixture was concentrated to dryness and purified by flash column chromatography on silica gel using mixtures of n-hexane and ethyl acetate as eluents.

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PMC11754094

We further investigated subsequent pathways leading to large deletions mediated by the BEs.

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PMC9429973

Image: Summary/Conclusion: Pts who completed 6 Tx cycles with FEDR 400 mg/d, whether used as 1L MF Tx or after RUX Tx, experienced substantial improvements in spleen volume and MF symptom severity regardless of the extent of splenomegaly at BL.

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PMC11314247

The results at 48 h show that DMSO maintained ≅ 95.3% of living cells, whereas chelerythrine showed apoptotic effects (Figure 2, Figure 3 and Figure 4).

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PMC11247842

As individual-level WGS data for the mapping populations were not available, we checked the LD of the CNV tag SNPs from Lee et al. with the CNV we found in the Nordic Holstein animals (Table 3).

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PMC10589262

As previously established by multiple studies, including ours, we confirmed that MT-KIT initiates downstream signaling in the Golgi complex.

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PMC9596868

Values represent mean ± SD of three technical replicates analysed by ANOVA with Dunnett's Multiple Comparison test. *

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PMC4360730

This process involves reviewing protocols, reagent vendor materials and primary literature to provide additional detail and verification for metadata of each category.

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PMC11047729

A study on the monocytic leukemia cells U937, SHI 1, and THP-1 showed Tan I-induced apoptosis through the activation of the caspase-3 pathway and slowed cell growth.

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PMC11699042

on R version 4.2.1.

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PMC11323699

Additionally, contradictory results have suggested that patients with advanced OC with high TSP-1 staining may experience improved survival .

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PMC11750712

Anti-CD7 CAR T have been tested in T cell acute lymphoblastic leukemia, with high response rates.

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PMC11683240

The number of replicates (n) for experiments or tested conditions is given in the figure legends.

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PMC9031474

The generation of ROS is not restricted to IR and can also result from endogenous (e.g., mitochondria) and exogenous sources (e.g., heavy metals, xenobiotics) .

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PMC11122631

There are two key roles for pharmacokinetics: P-glycoprotein and cytochrome P450 (CYP) enzymes.

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PMC3888431

De novo transcriptome assemblers produce a large number of misassembled or incomplete transcripts .

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PMC9512971

Overall, these findings highlight the continuing need to identify and develop alternative therapies for COVID-19 and the necessity of conducting well-designed studies to confirm whether preclinical findings translate into meaningful clinical efficacy.

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PMC11779993

cDNA was synthesized using SuperScript VILO™ cDNA synthesis kit (Thermo Fisher Scientific, USA).

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PMC11545737

There is well-established evidence that pyroptosis is often useful in controlling infections.

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PMC10578720

Specifically, succinate exerts its proinflammatory actions through many mechanisms, including stabilizing HIF-1α, affecting mitochondrial ROS production, and activating cell surface receptor, the G-protein–coupled receptor succinate receptor 1 in macrophages.

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PMC11474209

When ATM is autophosphorylated at Serine 1981 residue, the following signaling molecules in the cascade are activated, thereby repairing the damage.

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PMC11696576

As an energy source, FAO produces high levels of mitochondrial ROS, which can trigger programmed cell death.

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PMC11739504

The graph in Fig. 1d was generated from the results of three independent experiments under the identical conditions.

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PMC9622879

As the local buying/selling prices are better than the buying/selling prices proposed by the EP, this cost of each home in the community with the prosumer-centric CEMS and proposed CEMS is always better than that of each home in the community with no CEMS, where every home must directly trade its surplus energy with th...

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PMC11792888

However, some therapeutic properties are usually limited and accompanied by unwanted collateral effects.

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PMC11714165

The targeted nanoparticles efficiently inhibited tumor progression and osteosarcoma‐induced bone destruction in vivo.

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PMC10421378

Samples were measured after 1, 2, 3, 6, 9 and 12 months of storage or until the point at which their viability decreased below the 10 cfu/g threshold.

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PMC7351993

Third, without the molecular specificity provided by these labeling methods, intracellular fluorescent staining with fluorescent dyes suffers from non-specific binding and low quantitative performance since it relies on the difference in their chemical affinity to target biomolecules.

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PMC9429973

There is growing evidence that treatment needs to be individualised and with the growing use of lifestyle monitoring devices such as smartwatches, this wealth of information could be utilised to determine transfusion need.

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PMC9429973

At DL2, no SAE or dose limiting toxicity was reported up to the date of data cut off.

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PMC7171147

To determine whether high levels of FAO genes are associated with poor prognosis, we correlated the expression levels of FAO genes (CPT1A, ACAA2, and HADHA) with overall survival in high-grade serous ovarian cancer patients using the Kaplan–Meier plotter (https://kmplot.com).

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PMC11224020

The PDMS mixture was composed of PDMS A:cross-linker B at a ratio of 1:10 (wt/wt).

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PMC11736898

Responses to treatment were dominated by the relatively strong effects of vitamin D on induction of CAMP expression.

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PMC11082662

In contrast, the proposed SMPDL3B gene has the potential to serve as a new prognostic marker for diagnosing ovarian cancer, offering promise for enhancing the efficacy of diagnosis and treatment in women afflicted by this challenging disease.

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PMC11352666

Venetoclax is a BCL-2-selective small-molecule inhibitor that is FDA-approved in combination with other agents for the treatment of adults with chronic lymphocytic leukemia, small lymphocytic lymphoma, or AML .

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PMC9429973

Among the non-hematological adverse effects, the most common grade 3-4 adverse effects were nausea and vomiting (38.7%), fatigue (18.6%), and infection (18.6%).

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PMC7553912

a,b) Gene expression of OSM (a) and OSMRβ (b) in the kidney on days 0 (without GOx injection), 3, 6, or 9. (

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PMC11295144

They belong to a diverse family of GABA-gated Cl/HCO3 permeable ion channels that promote neuronal differentiation and synaptogenesis in the developing brain by increasing neuronal excitability (Owens and Kriegstein, 2002; Raimondo et al., 2017; Cherubini and Ben-Ari, 2023).

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PMC10914904

Notably, in UV-B-exposed keratinocytes lacking vtRNA 2-1, PKR phosphorylation is triggered, resulting in increased NF-κB activity and increased expression of the proinflammatory cytokines TNF-α, MMP-9, and COX-2, thus exacerbating inflammation and accelerating skin aging .

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PMC8389560

Background fluorescence was subtracted frame by frame using the Math Subtract plugin in ImageJ. Calcium responses were shown as a ratio of Fura-2 fluorescence intensities.

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PMC11473843

For the RNA sequencing, total RNA was extracted using a PureLink™ RNA Kit (Invitrogen, 12183018A), including an on-column DNase treatment (Invitrogen, 12185-010) according to the manufacturer’s instructions.

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PMC11759543

In the apoptosis pathway, caspase 8-caspase 3 cascade plays a significant part and might exhibit other signal(s) to the activation of caspases.

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PMC10470467

Validation of mRNA expression of 3 key genes in cell lines. (

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PMC11365983

The prevalence of high and low Gli2-mGFP signal intensity in 7 independent experiments is also significantly altered compared to control [high Gli2-mGFP signal intensity ≥ upper quartile, green bar; low ≤ lower quartile of control, blue]. [

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PMC11638255

h qRT-PCR analysis for the expression of genes in human neutrophils associated with intracellular copper (MT1X), migration (S100A8) and pro-inflammatory activation (ISG15) obtained after 30 min incubation in conditioned media as per (e).

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PMC11612508

Finally, the size distribution and average sizes of the NPs were analyzed using dynamic light scattering (DLS).

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PMC9429973

Image: Summary/Conclusion: Our study suggests that an altered pro-inflammatory anti-viral cytokine response pattern in children with E/R-BCP-ALL is specific to those children, who later developed the BCP-ALL.

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PMC11611077

For electrophysiological experiments, statistical analyses were performed using one-way ANOVA.

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PMC11756907

It was assumed that the reference system would be a 2-ME solution (0.5 mg/1 mL) appropriately diluted from the initial concentration of 2-ME obtained during the formation of the complex.

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PMC6379402

According to the gene expression data of cancer patients from TCGA, expression value of NUDT8 allows for stratifying cancer patients into subgroups having statistically significantly different survival curves (i.e., having different clinical outcomes) for eight cancer types: lung (log-rank p value = 4.12 × 10), liver (...

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PMC11767817

Compound 2a significantly increased SOD2, PON3, SIRT2, thioredoxin-1, p27, HIF-1α, FABP-1, and DKK-4 expression in 5637 cells.

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PMC11409031

We identified substantial disparities in the levels of diverse immune cell subcategories infiltrating tumors in high-risk versus low-risk cohorts.

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PMC11049294

Using the results of the AGAL activity measurement set on wild-type Jurkat cells, we examined the enzyme activity of GLA KO cells.

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PMC6600592

The docking software MOE 2008.10 was used for molecular docking of oxime derivatives and a protein residue in HLA-A2.1-restricted CTL epitope (PDB ID: 3OX8) was selected for docking study.

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PMC9429973

The annual rate of VOC experienced by the patient and leading to a healthcare visit within the preceding 12-months prior to crizanlizumab initiation and 12-month after will be assessed and compared as the primary outcome.

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PMC11470999

In animal models, PF effectively inhibited melanoma growth and metastasis to the lung and brain.

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PMC9429973

After multivariate analysis for age, aetiology and LDH>ULN, ≥5 HLH-2004 (HR 4.

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PMC8777939

With this approach, the overall five-year survival rate for ovarian cancer is approximately 46%.

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PMC9919300

Preclinical studies of curcumin indicate that it could be used for the treatment of hepatobiliary diseases .

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PMC9454178

Cell viability was assessed with the CCK-8 assay.

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